SIMILAR PATTERNS OF AMINO ACIDS FOR 2NYU_A_SAMA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		4 PRO A  62
ASP A  83
ASP A  99
ASP A  57
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
None
 1.14A 2nyuA-1eizA:
26.6		 2nyuA-1eizA:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		4 PRO A  62
ASP A  83
ASP A  99
ASP A 124
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
 0.45A 2nyuA-1eizA:
26.6		 2nyuA-1eizA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 PRO A 330
ASP A 333
ASP A  20
ASP A 336
 None
 1.46A 2nyuA-1gwiA:
undetectable		 2nyuA-1gwiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 PRO C 198
ASP C  35
ASP C  33
ASP C 200
 None
 1.17A 2nyuA-1mroC:
undetectable		 2nyuA-1mroC:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 PRO A 511
ASP A 509
ASP A 352
ASP A 497
 None
MG  A 701 ( 4.4A)
None
None
 1.12A 2nyuA-1n21A:
undetectable		 2nyuA-1n21A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		4 PRO A  10
ASP A  22
ASP A  35
ASP A  59
 None
 1.44A 2nyuA-1ry6A:
undetectable		 2nyuA-1ry6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		4 PRO A 257
ASP A 277
ASP A 303
ASP A 252
 None
 0.94A 2nyuA-1sqgA:
11.6		 2nyuA-1sqgA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		4 PRO A 257
ASP A 277
ASP A 303
ASP A 322
 None
 0.55A 2nyuA-1sqgA:
11.6		 2nyuA-1sqgA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 PRO A 128
ASP A  85
ASP A  83
ASP A  91
 None
 1.22A 2nyuA-1v0bA:
undetectable		 2nyuA-1v0bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		4 PRO A  65
ASP A 185
ASP A 192
ASP A  70
 None
None
DND  A 301 ( 4.2A)
None
 1.48A 2nyuA-1xngA:
2.5		 2nyuA-1xngA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Borreliella
burgdorferi) 		PF02127
(Peptidase_M18) 		4 PRO A  99
ASP A  97
ASP A 297
ASP A 335
 None
 1.48A 2nyuA-1y7eA:
undetectable		 2nyuA-1y7eA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 PRO A 324
ASP A 378
ASP A 370
ASP A 421
 None
 1.31A 2nyuA-1zr6A:
undetectable		 2nyuA-1zr6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PRO A 203
ASP A 237
ASP A 269
ASP A  22
 None
None
None
DQQ  A 801 (-2.8A)
 1.45A 2nyuA-2aeyA:
undetectable		 2nyuA-2aeyA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 PRO A 237
ASP A 258
ASP A 285
ASP A 232
 SAM  A1201 (-3.7A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 ( 4.4A)
 0.95A 2nyuA-2b9eA:
12.5		 2nyuA-2b9eA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 PRO A 237
ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-3.7A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.45A 2nyuA-2b9eA:
12.5		 2nyuA-2b9eA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 PRO A 104
ASP A 101
ASP A  59
ASP A 106
 None
SAH  A 501 (-2.9A)
SAH  A 501 ( 4.6A)
None
 1.40A 2nyuA-2eg5A:
8.7		 2nyuA-2eg5A:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		4 PRO A  33
ASP A  62
ASP A  79
ASP A  28
 SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 ( 4.8A)
 0.90A 2nyuA-2nyuA:
38.7		 2nyuA-2nyuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		4 PRO A  33
ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.00A 2nyuA-2nyuA:
38.7		 2nyuA-2nyuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		4 PRO A  41
ASP A  61
ASP A  83
ASP A  36
 None
SAH  A 301 (-2.7A)
SAH  A 301 (-3.2A)
SAH  A 301 ( 4.4A)
 0.99A 2nyuA-2p35A:
13.0		 2nyuA-2p35A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO B 143
ASP B  99
ASP B  97
ASP B 105
 None
 1.23A 2nyuA-2w9fB:
undetectable		 2nyuA-2w9fB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 PRO A 270
ASP A 291
ASP A 318
ASP A 265
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 ( 4.4A)
 0.96A 2nyuA-2yxlA:
11.7		 2nyuA-2yxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 PRO A 270
ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.50A 2nyuA-2yxlA:
11.7		 2nyuA-2yxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2

(Actinoplanes
teichomyceticus) 		PF02585
(PIG-L) 		4 PRO A 162
ASP A 129
ASP A 127
ASP A 169
 PG4  A 400 ( 4.7A)
None
None
None
 1.49A 2nyuA-3dffA:
4.3		 2nyuA-3dffA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		4 PRO A  53
ASP A  72
ASP A 100
ASP A  48
 None
SAM  A 220 (-2.9A)
SAM  A 220 (-3.2A)
SAM  A 220 ( 4.9A)
 1.11A 2nyuA-3dlcA:
10.7		 2nyuA-3dlcA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		4 PRO A  49
ASP A  67
ASP A  83
ASP A 111
 SAM  A   1 (-3.5A)
SAM  A   1 (-2.7A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.7A)
 0.50A 2nyuA-3douA:
24.8		 2nyuA-3douA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		4 PRO A 616
ASP A 618
ASP A 651
ASP A 613
 None
 1.31A 2nyuA-3i6sA:
2.0		 2nyuA-3i6sA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 PRO A 299
ASP A 338
ASP A 418
ASP A 331
 None
 1.44A 2nyuA-3lscA:
undetectable		 2nyuA-3lscA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
nitratireducens) 		PF02335
(Cytochrom_C552) 		4 PRO A 224
ASP A 191
ASP A 195
ASP A  62
 None
 1.37A 2nyuA-3s7wA:
undetectable		 2nyuA-3s7wA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli) 		PF01728
(FtsJ) 		4 PRO A 222
ASP A 240
ASP A 260
ASP A 277
 None
EDO  A1373 (-3.1A)
None
None
 0.88A 2nyuA-4aukA:
15.2		 2nyuA-4aukA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		4 PRO A 193
ASP A 132
ASP A  61
ASP A 145
 None
 1.29A 2nyuA-4aweA:
undetectable		 2nyuA-4aweA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 PRO A 515
ASP A 511
ASP A 605
ASP A 560
 None
 1.02A 2nyuA-4cakA:
undetectable		 2nyuA-4cakA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dia 2-PYRONE-4,6-DICARBA
XYLATE HYDROLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		4 PRO A 223
ASP A 219
ASP A 185
ASP A 226
 None
 1.18A 2nyuA-4diaA:
undetectable		 2nyuA-4diaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		4 PRO A 103
ASP A  98
ASP A  74
ASP A 250
 None
 1.17A 2nyuA-4eiuA:
undetectable		 2nyuA-4eiuA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PRO A 142
ASP A 296
ASP A 258
ASP A 334
 None
 1.45A 2nyuA-4ewtA:
undetectable		 2nyuA-4ewtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 PRO A 424
ASP A 188
ASP A 190
ASP A 310
 None
 1.13A 2nyuA-4flnA:
undetectable		 2nyuA-4flnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 PRO A 185
ASP A 204
ASP A 237
ASP A 179
 SAM  A 401 (-3.6A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.2A)
 1.09A 2nyuA-4fzvA:
9.4		 2nyuA-4fzvA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 PRO A 185
ASP A 204
ASP A 237
ASP A 255
 SAM  A 401 (-3.6A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.46A 2nyuA-4fzvA:
9.4		 2nyuA-4fzvA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt3 PUTATIVE LIPOPROTEIN

(Pseudomonas
protegens) 		no annotation 4 PRO B  79
ASP B  83
ASP B  66
ASP B  71
 None
 1.43A 2nyuA-4kt3B:
undetectable		 2nyuA-4kt3B:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 PRO C 201
ASP C  38
ASP C  36
ASP C 203
 None
 1.34A 2nyuA-5a8rC:
undetectable		 2nyuA-5a8rC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus) 		PF02240
(MCR_gamma) 		4 PRO C 202
ASP C  38
ASP C  36
ASP C 204
 None
 1.40A 2nyuA-5n28C:
undetectable		 2nyuA-5n28C:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 PRO A 245
ASP A 266
ASP A 293
ASP A 240
 C  C  72 ( 4.7A)
None
None
None
 1.30A 2nyuA-5wwtA:
10.6		 2nyuA-5wwtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 PRO A 245
ASP A 266
ASP A 293
ASP A 323
 C  C  72 ( 4.7A)
None
None
C  C  72 ( 2.8A)
 0.45A 2nyuA-5wwtA:
10.6		 2nyuA-5wwtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1d COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		no annotation 4 PRO A 199
ASP A 236
ASP A 227
ASP A 277
 None
CA  A 300 (-2.2A)
None
None
 1.16A 2nyuA-6f1dA:
undetectable		 2nyuA-6f1dA:
undetectable