SIMILAR PATTERNS OF AMINO ACIDS FOR 2NYR_B_SVRB401_4

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dex RHAMNOGALACTURONAN
ACETYLESTERASE

(Aspergillus
aculeatus) 		PF13472
(Lipase_GDSL_2) 		4 ALA A  45
ALA A 158
ALA A 159
VAL A 128
 None
 0.89A 2nyrB-1dexA:
2.7		 2nyrB-1dexA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 359
ALA A 453
ALA A 456
GLN A 413
 None
 0.92A 2nyrB-1ebdA:
3.5		 2nyrB-1ebdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		4 ALA A 105
ALA A  49
ALA A  53
VAL A  61
 None
 0.88A 2nyrB-1ezrA:
3.7		 2nyrB-1ezrA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 ALA A 261
ALA A 294
ALA A 278
GLN A 259
 None
 0.79A 2nyrB-1ixkA:
undetectable		 2nyrB-1ixkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		4 ALA A  84
ALA A 137
ALA A 141
VAL A  72
 None
 0.92A 2nyrB-1j0aA:
undetectable		 2nyrB-1j0aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 ALA A 256
ALA A 183
ALA A 214
GLN A 231
 None
 0.92A 2nyrB-1jyeA:
5.2		 2nyrB-1jyeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 ALA A 564
ALA A 485
ALA A 484
VAL A 551
 None
 0.94A 2nyrB-1kehA:
undetectable		 2nyrB-1kehA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 ALA A 238
ALA A 285
ALA A 316
VAL A 226
 None
 0.91A 2nyrB-1l8wA:
undetectable		 2nyrB-1l8wA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7n GAG POLYPROTEIN
CAPSID PROTEIN P27

(Rous sarcoma
virus) 		no annotation 4 ALA A 134
ALA A  83
ALA A  82
GLN A  76
 None
 0.85A 2nyrB-1p7nA:
undetectable		 2nyrB-1p7nA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR

(Escherichia
coli) 		PF02261
(Asp_decarbox) 		4 ALA A  59
ALA A  36
ALA A 106
VAL A  13
 None
 0.93A 2nyrB-1ppyA:
undetectable		 2nyrB-1ppyA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 ALA C 148
ALA C 212
ALA C 196
VAL C  96
 None
 0.89A 2nyrB-1t3qC:
undetectable		 2nyrB-1t3qC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 ALA A 432
ALA A 401
ALA A 413
VAL A 366
 None
 0.91A 2nyrB-1wytA:
2.2		 2nyrB-1wytA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzp PEROXIDASE
MANGANESE-DEPENDENT
I

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ALA A  37
ALA A 120
GLN A  25
VAL A 293
 None
 0.74A 2nyrB-1yzpA:
undetectable		 2nyrB-1yzpA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		4 ALA A 137
ALA A 200
GLN A 242
VAL A 206
 AMP  A1002 (-3.7A)
None
None
None
 0.94A 2nyrB-1zbuA:
undetectable		 2nyrB-1zbuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01380
(SIS) 		4 ALA A  77
ALA A  48
GLN A 116
VAL A 120
 None
 0.86A 2nyrB-2a3nA:
6.5		 2nyrB-2a3nA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		4 ALA C 395
ALA C 316
ALA C 315
VAL C 382
 None
 0.93A 2nyrB-2advC:
undetectable		 2nyrB-2advC:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 ALA A 447
ALA A 429
ALA A 433
GLN A 394
 None
 0.91A 2nyrB-2cfoA:
undetectable		 2nyrB-2cfoA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ALA A 123
ALA A  89
ALA A 114
VAL A 152
 None
 0.92A 2nyrB-2cvzA:
4.1		 2nyrB-2cvzA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		4 ALA A 232
ALA A 257
ALA A 262
VAL A 207
 None
 0.87A 2nyrB-2fk6A:
undetectable		 2nyrB-2fk6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz2 CYANOGLOBIN

(Synechocystis
sp. PCC 6803) 		PF01152
(Bac_globin) 		4 ALA A  17
ALA A  54
ALA A 112
VAL A  87
 None
None
None
HEM  A 125 (-4.8A)
 0.89A 2nyrB-2hz2A:
undetectable		 2nyrB-2hz2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 129
ALA A 101
ALA A 104
VAL A  68
 None
 0.89A 2nyrB-2iikA:
undetectable		 2nyrB-2iikA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 ALA A1098
ALA A1150
GLN A1143
VAL A1185
 None
 0.93A 2nyrB-2ix8A:
undetectable		 2nyrB-2ix8A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		4 ALA A 140
ALA A 115
ALA A  95
GLN A  99
 None
None
None
MES  A1176 (-3.3A)
 0.87A 2nyrB-2j8kA:
undetectable		 2nyrB-2j8kA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjq DNAA-RELATED PROTEIN

(Neisseria
meningitidis) 		no annotation 4 ALA A  72
ALA A  81
ALA A  84
VAL A  57
 None
 0.83A 2nyrB-2kjqA:
undetectable		 2nyrB-2kjqA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 ALA A 185
ALA A 303
ALA A 324
GLN A 106
 None
FMN  A 373 (-3.5A)
None
FMN  A 373 (-2.8A)
 0.89A 2nyrB-2q3rA:
undetectable		 2nyrB-2q3rA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 ALA A 379
ALA A 472
ALA A 476
VAL A 239
 None
 0.92A 2nyrB-2qveA:
undetectable		 2nyrB-2qveA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 ALA A 254
ALA A 313
ALA A 159
VAL A 174
 None
 0.93A 2nyrB-2xqyA:
undetectable		 2nyrB-2xqyA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A 341
ALA A 371
ALA A 370
VAL A 426
 None
 0.93A 2nyrB-2yfhA:
undetectable		 2nyrB-2yfhA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		4 ALA A 361
ALA A 291
ALA A 294
GLN A 358
 HEM  A 413 (-3.5A)
HEM  A 413 ( 3.7A)
VDX  A 501 ( 3.8A)
None
 0.73A 2nyrB-2zbzA:
undetectable		 2nyrB-2zbzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmb ACETOACETATE
DECARBOXYLASE

(Methanoculleus
marisnigri) 		PF06314
(ADC) 		4 ALA A  99
ALA A  63
ALA A  33
GLN A 201
 None
None
None
P33  A 269 (-3.4A)
 0.88A 2nyrB-3cmbA:
undetectable		 2nyrB-3cmbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ALA A  99
ALA A  77
GLN A  44
VAL A 108
 None
 0.89A 2nyrB-3cp2A:
3.5		 2nyrB-3cp2A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		4 ALA A 291
ALA A 247
ALA A 243
VAL A 255
 None
 0.93A 2nyrB-3e49A:
undetectable		 2nyrB-3e49A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		4 ALA A 395
ALA A 353
ALA A 348
VAL A 381
 None
 0.90A 2nyrB-3ek1A:
4.4		 2nyrB-3ek1A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)

(Paracoccus
denitrificans) 		PF05853
(BKACE) 		4 ALA A 245
ALA A  42
ALA A  47
GLN A 215
 None
 0.92A 2nyrB-3fa5A:
undetectable		 2nyrB-3fa5A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftp 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 ALA A  15
ALA A  28
ALA A  32
VAL A  87
 None
 0.86A 2nyrB-3ftpA:
4.3		 2nyrB-3ftpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6e 50S RIBOSOMAL
PROTEIN L22P

(Haloarcula
marismortui) 		PF00237
(Ribosomal_L22) 		4 ALA R  43
ALA R  95
ALA R  16
VAL R 143
 None
None
G  0 500 ( 4.1A)
None
 0.76A 2nyrB-3g6eR:
undetectable		 2nyrB-3g6eR:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 ALA A  19
ALA A  32
ALA A  36
VAL A  91
 None
 0.85A 2nyrB-3gafA:
4.8		 2nyrB-3gafA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbp GALACTOSE-BINDING
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		4 ALA A  31
ALA A 273
ALA A  62
VAL A   7
 None
 0.92A 2nyrB-3gbpA:
5.9		 2nyrB-3gbpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 ALA A 140
ALA A  96
ALA A 100
GLN A 152
VAL A 112
 None
 1.45A 2nyrB-3hutA:
3.2		 2nyrB-3hutA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j15 PROTEIN PELOTA

(Pyrococcus
furiosus) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 ALA A 321
ALA A 350
ALA A 282
VAL A 356
 None
 0.93A 2nyrB-3j15A:
undetectable		 2nyrB-3j15A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y MS30

(Homo sapiens) 		PF00829
(Ribosomal_L21p) 		4 ALA s 248
ALA s 194
ALA s 198
GLN s 358
 None
 0.92A 2nyrB-3j7ys:
undetectable		 2nyrB-3j7ys:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 ALA A 396
ALA A 569
GLN A 524
VAL A 573
 None
 0.94A 2nyrB-3kbhA:
undetectable		 2nyrB-3kbhA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lub PUTATIVE CREATININE
AMIDOHYDROLASE

(Bacteroides
fragilis) 		PF02633
(Creatininase) 		4 ALA A 143
ALA A  53
ALA A  54
VAL A  22
 None
 0.93A 2nyrB-3lubA:
undetectable		 2nyrB-3lubA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7n PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Archaeoglobus
fulgidus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ALA D 143
ALA D 190
ALA D 202
VAL D 112
 None
 0.80A 2nyrB-3m7nD:
undetectable		 2nyrB-3m7nD:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mds MANGANESE SUPEROXIDE
DISMUTASE

(Thermus
thermophilus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ALA A 186
ALA A 124
ALA A 133
VAL A 163
 None
 0.90A 2nyrB-3mdsA:
undetectable		 2nyrB-3mdsA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on3 KETO/OXOACID
FERREDOXIN
OXIDOREDUCTASE,
GAMMA SUBUNIT

(Geobacter
sulfurreducens) 		PF01558
(POR) 		4 ALA A  72
ALA A 177
ALA A 180
GLN A 110
 None
 0.87A 2nyrB-3on3A:
2.6		 2nyrB-3on3A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ALA A  26
ALA A 414
ALA A 187
VAL A 189
 None
 0.92A 2nyrB-3p4sA:
undetectable		 2nyrB-3p4sA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ALA A  19
ALA A  32
ALA A  36
VAL A 104
 None
 0.94A 2nyrB-3pgxA:
4.4		 2nyrB-3pgxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjv PUTATIVE SEL1 REPEAT
PROTEIN

(Klebsiella
pneumoniae) 		PF08238
(Sel1) 		4 ALA A 131
ALA A  70
ALA A  73
VAL A 110
 None
 0.86A 2nyrB-3rjvA:
undetectable		 2nyrB-3rjvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sds ORNITHINE
CARBAMOYLTRANSFERASE
, MITOCHONDRIAL

(Coccidioides
immitis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ALA A 212
ALA A 294
ALA A 289
VAL A 284
 None
 0.84A 2nyrB-3sdsA:
3.1		 2nyrB-3sdsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ALA A 325
ALA A 426
ALA A 425
GLN A 504
 None
 0.88A 2nyrB-3sqgA:
undetectable		 2nyrB-3sqgA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ALA A 326
ALA A 426
ALA A 425
GLN A 504
 None
 0.91A 2nyrB-3sqgA:
undetectable		 2nyrB-3sqgA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swo GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 159
ALA A 241
ALA A 246
GLN A 189
 None
 0.79A 2nyrB-3swoA:
undetectable		 2nyrB-3swoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w64 MAGNETOSOME PROTEIN
MAMM

(Magnetospirillum
gryphiswaldense) 		PF16916
(ZT_dimer) 		4 ALA A 216
ALA A 239
ALA A 248
VAL A 274
 None
 0.90A 2nyrB-3w64A:
undetectable		 2nyrB-3w64A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w8g MAGNETOSOME PROTEIN
MAMM

(Magnetospirillum
gryphiswaldense) 		PF16916
(ZT_dimer) 		4 ALA A 216
ALA A 239
ALA A 248
VAL A 274
 None
 0.93A 2nyrB-3w8gA:
undetectable		 2nyrB-3w8gA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ALA A 363
ALA A 271
ALA A 280
VAL A 316
 None
 0.93A 2nyrB-4a1oA:
5.1		 2nyrB-4a1oA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A 342
ALA A 372
ALA A 371
VAL A 426
 None
 0.90A 2nyrB-4bhtA:
undetectable		 2nyrB-4bhtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cql ESTRADIOL
17-BETA-DEHYDROGENAS
E 8

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 ALA A  19
ALA A  32
ALA A  36
VAL A  99
 None
 0.94A 2nyrB-4cqlA:
5.0		 2nyrB-4cqlA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ALA A  37
ALA A 120
GLN A  25
VAL A 297
 None
 0.81A 2nyrB-4czpA:
undetectable		 2nyrB-4czpA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djf CORRINOID/IRON-SULFU
R PROTEIN LARGE
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD)
PF04060
(FeS) 		4 ALA C 288
ALA C  95
ALA C 130
VAL C  73
 None
 0.76A 2nyrB-4djfC:
undetectable		 2nyrB-4djfC:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Synechococcus
elongatus) 		PF13561
(adh_short_C2) 		4 ALA A  16
ALA A  29
ALA A  33
VAL A  89
 None
 0.94A 2nyrB-4dmmA:
5.1		 2nyrB-4dmmA:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 ALA A  59
ALA A  82
ALA A  86
VAL A 220
 CNA  A 402 (-3.0A)
None
None
None
 0.76A 2nyrB-4g1cA:
38.3		 2nyrB-4g1cA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40) 		4 ALA B  23
ALA B 252
ALA B 262
VAL B 270
 None
 0.86A 2nyrB-4g56B:
undetectable		 2nyrB-4g56B:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ALA A 141
ALA A 361
GLN A 108
VAL A 413
 None
None
SO4  A 902 (-3.5A)
None
 0.89A 2nyrB-4i3gA:
7.3		 2nyrB-4i3gA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		4 ALA A 360
ALA A 284
GLN A 486
VAL A 297
 None
 0.86A 2nyrB-4impA:
4.5		 2nyrB-4impA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 ALA A 325
ALA A 343
GLN A 548
VAL A 405
 None
 0.94A 2nyrB-4jkmA:
undetectable		 2nyrB-4jkmA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3w LIPASE

(Rhizopus
microsporus) 		PF01764
(Lipase_3) 		4 ALA A  54
ALA A 178
ALA A 181
VAL A 146
 None
 0.92A 2nyrB-4l3wA:
undetectable		 2nyrB-4l3wA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9c BACTERIAL
TRANSFERASE
HEXAPEPTIDE (THREE
REPEATS) FAMILY
PROTEIN

(Acinetobacter
baumannii) 		PF00132
(Hexapep) 		4 ALA A 152
ALA A 164
ALA A 187
VAL A 205
 None
 0.88A 2nyrB-4m9cA:
undetectable		 2nyrB-4m9cA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mow GLUCOSE
1-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		4 ALA A  14
ALA A  27
ALA A  31
VAL A  87
 None
 0.89A 2nyrB-4mowA:
4.8		 2nyrB-4mowA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 353
ALA A  10
ALA A  37
GLN A 115
VAL A 111
 None
 1.41A 2nyrB-4o99A:
undetectable		 2nyrB-4o99A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oko RAPID ENCYSTMENT
PHENOTYPE PROTEIN 34
KDA

(Francisella
tularensis) 		PF00246
(Peptidase_M14) 		4 ALA A 295
ALA A 222
GLN A 289
VAL A 226
 None
 0.88A 2nyrB-4okoA:
undetectable		 2nyrB-4okoA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo2 CHLOROPHENOL-4-MONOO
XYGENASE

(Streptomyces
globisporus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ALA A 209
ALA A 201
ALA A 269
VAL A  36
 None
 0.94A 2nyrB-4oo2A:
undetectable		 2nyrB-4oo2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ALA A  79
ALA A 118
ALA A  95
VAL A  28
 None
 0.92A 2nyrB-4rncA:
2.1		 2nyrB-4rncA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		4 ALA A 207
ALA A 325
ALA A 322
VAL A 184
 None
 0.86A 2nyrB-4rp8A:
undetectable		 2nyrB-4rp8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xin LPQH ORTHOLOGUE

(Mycobacterium
avium) 		PF05481
(Myco_19_kDa) 		4 ALA A 118
ALA A 104
GLN A  72
VAL A  69
 None
 0.93A 2nyrB-4xinA:
undetectable		 2nyrB-4xinA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zev PFHAD1

(Plasmodium
falciparum) 		PF08282
(Hydrolase_3) 		4 ALA A 266
ALA A  27
ALA A  60
VAL A 219
 None
M6P  A 302 (-3.3A)
None
None
 0.75A 2nyrB-4zevA:
5.0		 2nyrB-4zevA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A  76
ALA A 119
ALA A  35
VAL A  21
 None
 0.89A 2nyrB-5boeA:
undetectable		 2nyrB-5boeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqm SOMATOLIBERIN,BOTULI
NUM NEUROTOXIN TYPE
D

(Clostridium
botulinum;
Homo sapiens) 		PF07952
(Toxin_trans) 		4 ALA B 633
ALA B 799
ALA B 802
VAL B 621
 None
 0.86A 2nyrB-5bqmB:
undetectable		 2nyrB-5bqmB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4r PRECORRIN-6A
REDUCTASE

(Rhodobacter
capsulatus) 		PF02571
(CbiJ) 		4 ALA A  21
ALA A  71
GLN A  19
VAL A 237
 None
 0.92A 2nyrB-5c4rA:
6.3		 2nyrB-5c4rA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 ALA A1020
ALA A 902
ALA A 918
VAL A 614
 None
 0.94A 2nyrB-5cjuA:
undetectable		 2nyrB-5cjuA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA

(Mycolicibacterium
thermoresistibile) 		no annotation 4 ALA C 264
ALA C 279
ALA C 283
VAL C 123
 None
 0.68A 2nyrB-5cw2C:
2.6		 2nyrB-5cw2C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwi DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A 107
ALA A 195
ALA A 194
VAL A 228
 None
 0.83A 2nyrB-5cwiA:
undetectable		 2nyrB-5cwiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwi DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A 137
ALA A 195
GLN A 103
VAL A 168
 None
 0.92A 2nyrB-5cwiA:
undetectable		 2nyrB-5cwiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwi DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A 138
ALA A 134
GLN A  43
VAL A 108
 None
 0.88A 2nyrB-5cwiA:
undetectable		 2nyrB-5cwiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwi DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A 198
ALA A 194
GLN A 103
VAL A 168
 None
 0.82A 2nyrB-5cwiA:
undetectable		 2nyrB-5cwiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		4 ALA B 495
ALA B 551
ALA B 550
VAL B 467
 None
 0.81A 2nyrB-5do7B:
undetectable		 2nyrB-5do7B:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA

(Moorella
thermoacetica) 		PF00037
(Fer4)
PF01558
(POR) 		4 ALA B  34
ALA B 195
ALA B 144
VAL B 147
 None
 0.89A 2nyrB-5exeB:
2.2		 2nyrB-5exeB:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsp MAGNETOSOME PROTEIN
MAMM

(Magnetospirillum
gryphiswaldense) 		PF16916
(ZT_dimer) 		4 ALA A 216
ALA A 239
ALA A 248
VAL A 274
 None
 0.91A 2nyrB-5hspA:
undetectable		 2nyrB-5hspA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR

(Trypanosoma
brucei) 		no annotation 4 ALA D 170
ALA D 213
ALA D 216
VAL D 220
 None
 0.90A 2nyrB-5hu6D:
undetectable		 2nyrB-5hu6D:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 124
ALA A 317
ALA A 321
GLN A 397
 None
 0.92A 2nyrB-5lnqA:
undetectable		 2nyrB-5lnqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lo9 CYTOCHROME C

(Marichromatium
purpuratum) 		PF00034
(Cytochrom_C)
PF13442
(Cytochrome_CBB3) 		4 ALA A 108
ALA A 187
ALA A  95
VAL A  99
 None
 0.85A 2nyrB-5lo9A:
undetectable		 2nyrB-5lo9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpi GRAINYHEAD-LIKE
PROTEIN 1 HOMOLOG

(Homo sapiens) 		no annotation 4 ALA A 355
ALA A 358
GLN A 317
VAL A 306
 None
 0.92A 2nyrB-5mpiA:
undetectable		 2nyrB-5mpiA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE

(metagenome) 		no annotation 4 ALA A 132
ALA A 112
ALA A 123
VAL A 243
 None
 0.94A 2nyrB-5nfqA:
undetectable		 2nyrB-5nfqA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		4 ALA A  42
ALA A 202
ALA A 205
VAL A  55
 None
 0.71A 2nyrB-5uidA:
undetectable		 2nyrB-5uidA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 4 ALA A  37
ALA A  42
GLN A  49
VAL A  68
 None
 0.77A 2nyrB-5w76A:
3.5		 2nyrB-5w76A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 4 ALA A  37
ALA A  42
GLN A  49
VAL A  68
 None
 0.87A 2nyrB-5w7qA:
3.5		 2nyrB-5w7qA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 4 ALA A 322
ALA A 376
ALA A 377
VAL A 303
 None
 0.90A 2nyrB-5wt4A:
2.1		 2nyrB-5wt4A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases) 		4 ALA D 458
ALA D 434
ALA D 435
VAL D  37
 None
 0.89A 2nyrB-5xfaD:
undetectable		 2nyrB-5xfaD:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 4 ALA A 115
ALA A  25
ALA A 220
VAL A 189
 None
 0.94A 2nyrB-6co0A:
undetectable		 2nyrB-6co0A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dzs HOMOSERINE
DEHYDROGENASE

(Mycolicibacterium
hassiacum) 		no annotation 4 ALA A 308
ALA A 204
ALA A 252
VAL A 291
 NAP  A 500 ( 3.9A)
None
None
None
 0.90A 2nyrB-6dzsA:
5.8		 2nyrB-6dzsA:
undetectable