SIMILAR PATTERNS OF AMINO ACIDS FOR 2NYR_B_SVRB401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ARG A  75
ASN A  94
ASN A 102
LEU A  19
 None
 1.28A 2nyrA-1dnpA:
1.5		 2nyrA-1dnpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		4 PHE A 474
GLN A 456
ASN A 468
LEU A 439
 None
 1.18A 2nyrA-1gz7A:
0.4		 2nyrA-1gz7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 GLN A  81
ASN A 115
ASN A  86
LEU A 120
 None
 1.14A 2nyrA-1moxA:
undetectable		 2nyrA-1moxA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ARG A 498
ASN A 504
ASN A 268
LEU A 217
 None
 1.29A 2nyrA-1ofeA:
undetectable		 2nyrA-1ofeA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9m INTERLEUKIN-6
RECEPTOR ALPHA CHAIN
INTERLEUKIN-6
RECEPTOR BETA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		4 PHE A 275
GLN A 249
ASN A 236
ASN C 211
 None
 1.29A 2nyrA-1p9mA:
undetectable		 2nyrA-1p9mA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ECDYSONE RECEPTOR

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		4 ARG D 387
ASN D 400
ASN D 504
LEU D 522
 None
None
HWG  D2000 (-3.0A)
None
 1.26A 2nyrA-1r20D:
undetectable		 2nyrA-1r20D:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ARG A 185
GLN A 171
ASN A  30
ASN A  67
 None
 1.25A 2nyrA-1rxwA:
2.5		 2nyrA-1rxwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryt RUBRERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		4 PHE A  46
ARG A 134
GLN A  52
LEU A  60
 None
 1.26A 2nyrA-1rytA:
undetectable		 2nyrA-1rytA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5e THIOREDOXIN DOMAIN
CONTAINING PROTEIN 1

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 PHE A  73
ARG A  91
ASN A  76
ASN A  39
 None
 1.30A 2nyrA-1x5eA:
undetectable		 2nyrA-1x5eA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1

(Enterococcus
faecalis) 		PF04962
(KduI) 		4 PHE A1024
ARG A1021
GLN A1233
ASN A1000
 None
 1.25A 2nyrA-1ywkA:
undetectable		 2nyrA-1ywkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgh METHIONYL-TRNA
FORMYLTRANSFERASE

(Ruminiclostridium
thermocellum) 		PF00551
(Formyl_trans_N) 		4 PHE A  80
ARG A  82
GLN A 155
LEU A 145
 None
 1.19A 2nyrA-1zghA:
4.4		 2nyrA-1zghA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7u ATP SYNTHASE DELTA
CHAIN

(Escherichia
coli) 		PF00213
(OSCP) 		4 PHE B   3
ASN B  86
ASN B  71
LEU B  68
 None
 1.25A 2nyrA-2a7uB:
undetectable		 2nyrA-2a7uB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e11 HYDROLASE

(Xanthomonas
campestris) 		PF00795
(CN_hydrolase) 		4 PHE A  49
ARG A 203
ASN A  21
LEU A  32
 CAC  A1266 (-3.3A)
None
None
None
 1.10A 2nyrA-2e11A:
undetectable		 2nyrA-2e11A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		4 PHE A 238
ARG A 239
ASN A 205
LEU A  97
 None
 1.15A 2nyrA-2ejaA:
undetectable		 2nyrA-2ejaA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A 402
ASN A 369
ASN A 290
LEU A 303
 None
1BM  A 499 (-4.1A)
None
None
 1.24A 2nyrA-2hk5A:
undetectable		 2nyrA-2hk5A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF07995
(GSDH) 		4 ARG A 318
GLN A 205
ASN A 203
LEU A 216
 CL  A1003 (-3.1A)
CL  A1003 (-3.1A)
None
None
 1.20A 2nyrA-2ismA:
undetectable		 2nyrA-2ismA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		4 PHE B 237
ARG B 217
GLN B 229
LEU A 867
 None
 1.08A 2nyrA-2ivfB:
undetectable		 2nyrA-2ivfB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd0 HYPOTHETICAL PROTEIN

(Cryptosporidium
parvum) 		PF11539
(DUF3228) 		4 ARG A 142
ASN A  33
ASN A   6
LEU A  10
 None
None
MES  A 502 (-3.2A)
None
 1.25A 2nyrA-2pd0A:
undetectable		 2nyrA-2pd0A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1

(Streptococcus
agalactiae) 		PF13672
(PP2C_2) 		4 GLN A  17
ASN A  15
ASN A 190
LEU A  34
 None
 1.17A 2nyrA-2pk0A:
undetectable		 2nyrA-2pk0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x27 OUTER MEMBRANE
PROTEIN OPRG

(Pseudomonas
aeruginosa) 		PF03922
(OmpW) 		4 PHE X 155
ARG X  13
GLN X 100
LEU X 149
 C8E  X1224 ( 4.7A)
None
None
C8E  X1223 (-4.1A)
 1.19A 2nyrA-2x27X:
undetectable		 2nyrA-2x27X:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xnq NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 PHE A 371
ARG A 331
GLN A 359
ASN A 341
 None
 1.14A 2nyrA-2xnqA:
undetectable		 2nyrA-2xnqA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF

(Drosophila
melanogaster) 		no annotation 4 PHE A 272
GLN A 274
ASN A 308
ASN A 286
 None
 1.27A 2nyrA-2xz8A:
undetectable		 2nyrA-2xz8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		4 ARG A 814
ASN A 749
ASN A 917
LEU A 868
 BTB  A1945 (-3.9A)
BTB  A1945 (-3.7A)
None
None
 1.25A 2nyrA-2yhgA:
4.1		 2nyrA-2yhgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgk ANTI-TUMOR LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 ARG A  85
ASN A  43
ASN A 116
LEU A  33
 None
 1.08A 2nyrA-2zgkA:
undetectable		 2nyrA-2zgkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		4 PHE A  19
ARG A  58
ASN A  63
LEU A 147
 None
 1.30A 2nyrA-3b59A:
undetectable		 2nyrA-3b59A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220

(Histophilus
somni) 		PF05114
(DUF692) 		4 PHE A  91
ASN A 200
ASN A 173
LEU A 254
 None
 1.31A 2nyrA-3bwwA:
undetectable		 2nyrA-3bwwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 4 GLN A 609
ASN A 605
ASN A 585
LEU A 650
 None
 1.05A 2nyrA-3c2gA:
undetectable		 2nyrA-3c2gA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5i CHOLINE KINASE

(Plasmodium
knowlesi) 		PF01633
(Choline_kinase) 		4 PHE A 267
GLN A 220
ASN A 222
LEU A 132
 None
CHT  A1001 (-3.2A)
MG  A 370 ( 4.4A)
None
 1.24A 2nyrA-3c5iA:
undetectable		 2nyrA-3c5iA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 PHE A 281
ARG A 298
ASN A 309
LEU A 355
 None
 1.30A 2nyrA-3cv2A:
undetectable		 2nyrA-3cv2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		4 ARG A 311
GLN A 205
ASN A 203
LEU A 215
 PQQ  A4331 (-2.9A)
PQQ  A4331 (-3.0A)
PQQ  A4331 (-3.9A)
None
 1.26A 2nyrA-3dasA:
undetectable		 2nyrA-3dasA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 PHE A 273
ARG A 275
ASN A 268
ASN A  47
 None
None
None
ACT  A1108 (-4.0A)
 0.93A 2nyrA-3ed3A:
undetectable		 2nyrA-3ed3A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvq FE(3+) IONS IMPORT
ATP-BINDING PROTEIN
FBPC

(Neisseria
gonorrhoeae) 		PF00005
(ABC_tran) 		4 PHE A  53
GLN A  55
ASN A  74
ASN A  21
 None
 1.17A 2nyrA-3fvqA:
undetectable		 2nyrA-3fvqA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01436
(NHL) 		4 PHE A 531
GLN A 516
ASN A 804
ASN A 733
 None
HH3  A   1 ( 4.7A)
None
None
 1.26A 2nyrA-3fw0A:
undetectable		 2nyrA-3fw0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv0 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Agrobacterium
fabrum) 		PF13377
(Peripla_BP_3) 		4 PHE A  82
GLN A 282
ASN A 298
LEU A 180
 None
 1.26A 2nyrA-3gv0A:
3.7		 2nyrA-3gv0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		4 PHE A1169
GLN A 913
ASN A 917
ASN A 904
 None
 0.89A 2nyrA-3i36A:
undetectable		 2nyrA-3i36A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ARG A 390
GLN A 181
ASN A 134
LEU A 308
 None
 1.27A 2nyrA-3igoA:
undetectable		 2nyrA-3igoA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 GLN A  81
ASN A 115
ASN A  86
LEU A 120
 None
 1.07A 2nyrA-3njpA:
undetectable		 2nyrA-3njpA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p13 D-RIBOSE PYRANASE

(Staphylococcus
aureus) 		PF05025
(RbsD_FucU) 		4 ARG A  52
GLN A  82
ASN A  79
ASN A 116
 None
 1.25A 2nyrA-3p13A:
undetectable		 2nyrA-3p13A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p13 D-RIBOSE PYRANASE

(Staphylococcus
aureus) 		PF05025
(RbsD_FucU) 		4 ARG A  52
GLN A  82
ASN A  79
LEU A 130
 None
 0.97A 2nyrA-3p13A:
undetectable		 2nyrA-3p13A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13306
(LRR_5) 		4 PHE A 140
GLN A 121
ASN A 145
ASN A  45
 None
 1.31A 2nyrA-3sb4A:
undetectable		 2nyrA-3sb4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Coxiella
burnetii) 		PF00698
(Acyl_transf_1) 		4 ARG A 118
GLN A 251
ASN A 232
ASN A 242
 GLY  A 314 (-3.2A)
None
None
GLY  A 315 ( 4.8A)
 1.19A 2nyrA-3tqeA:
2.1		 2nyrA-3tqeA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Coxiella
burnetii) 		PF00698
(Acyl_transf_1) 		4 PHE A   9
GLN A 251
ASN A 232
ASN A 242
 None
None
None
GLY  A 315 ( 4.8A)
 1.12A 2nyrA-3tqeA:
2.1		 2nyrA-3tqeA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE

(Caulobacter
vibrioides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 223
ASN A 189
ASN A 402
LEU A 395
 None
 1.04A 2nyrA-3vcnA:
undetectable		 2nyrA-3vcnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 PHE A 437
GLN A 431
ASN A 400
LEU A 423
 None
 1.10A 2nyrA-4c3hA:
undetectable		 2nyrA-4c3hA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 PHE A 695
ARG A 697
ASN A 829
LEU A 765
 None
 1.26A 2nyrA-4cu8A:
undetectable		 2nyrA-4cu8A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnv AT5G63860/MGI19_6

(Arabidopsis
thaliana) 		PF00415
(RCC1) 		4 PHE A 370
GLN A 316
ASN A 303
LEU A 270
 None
 1.19A 2nyrA-4dnvA:
undetectable		 2nyrA-4dnvA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffb PROTEIN STU2

(Saccharomyces
cerevisiae) 		no annotation 4 GLN C 122
ASN C  80
ASN C  68
LEU C  27
 None
 1.18A 2nyrA-4ffbC:
undetectable		 2nyrA-4ffbC:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 PHE A 240
GLN A 246
ASN A 307
LEU A 254
 None
 1.20A 2nyrA-4fgvA:
undetectable		 2nyrA-4fgvA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 PHE B 551
ARG B 581
GLN B 689
LEU B 599
 None
 1.07A 2nyrA-4fhnB:
undetectable		 2nyrA-4fhnB:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLN A 483
ASN A 517
ASN A 504
LEU A 468
 None
 1.24A 2nyrA-4flnA:
undetectable		 2nyrA-4flnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN

(Arabidopsis
thaliana) 		PF00225
(Kinesin) 		4 ARG A 895
GLN A 944
ASN A 986
LEU A1068
 ADP  A1302 (-4.0A)
None
None
None
 1.26A 2nyrA-4frzA:
undetectable		 2nyrA-4frzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		4 PHE A 261
ARG A 237
ASN A 298
LEU A  79
 None
 1.15A 2nyrA-4gxwA:
undetectable		 2nyrA-4gxwA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB
YENC2

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
no annotation 		4 PHE A1097
GLN B  82
ASN B  88
LEU B 671
 None
 1.26A 2nyrA-4iglA:
undetectable		 2nyrA-4iglA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5a DESIGNED ANKYRIN
REPEAT PROTEIN
013_D12

(Escherichia
coli) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 GLN B 122
ASN B 156
ASN B 107
LEU B 132
 None
 1.23A 2nyrA-4k5aB:
undetectable		 2nyrA-4k5aB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1

(Homo sapiens) 		PF16363
(GDP_Man_Dehyd) 		4 PHE A  99
ARG A 125
ASN A 269
ASN A 171
 None
SO4  A 504 ( 4.4A)
SO4  A 504 (-3.8A)
None
 1.27A 2nyrA-4lk3A:
4.6		 2nyrA-4lk3A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		4 ARG A  49
GLN A  77
ASN A  71
LEU A 112
 None
 1.21A 2nyrA-4mh1A:
undetectable		 2nyrA-4mh1A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		4 PHE A 205
GLN A 208
ASN A 359
LEU A 409
 None
 0.99A 2nyrA-4opuA:
3.9		 2nyrA-4opuA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pa1 INTEGRASE

(Feline
immunodeficiency
virus) 		PF00665
(rve) 		4 PHE A 141
GLN A  64
ASN A 111
LEU A 202
 None
 1.10A 2nyrA-4pa1A:
undetectable		 2nyrA-4pa1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		4 GLN A 294
ASN A 377
ASN A 311
LEU A 329
 None
None
MG  A 502 ( 2.5A)
None
 1.15A 2nyrA-4pu5A:
undetectable		 2nyrA-4pu5A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbj GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Aspergillus
fumigatus) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 ARG A 236
ASN A 241
ASN A 213
LEU A 168
 None
None
2XQ  A 505 ( 3.5A)
None
 1.30A 2nyrA-4qbjA:
undetectable		 2nyrA-4qbjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 PHE A 550
GLN A 585
ASN A 613
LEU A 697
 None
 1.28A 2nyrA-4r04A:
undetectable		 2nyrA-4r04A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm4 CYTOCHROME P450

(Bacillus
subtilis) 		PF00067
(p450) 		4 ARG A 184
ASN A  79
ASN A  45
LEU A 311
 None
 1.17A 2nyrA-4rm4A:
undetectable		 2nyrA-4rm4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLN A 243
ASN A 239
ASN A 268
LEU A 264
 None
None
MG  A1439 ( 3.0A)
None
 1.19A 2nyrA-4uyaA:
undetectable		 2nyrA-4uyaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wkr LA-RELATED PROTEIN 7

(Homo sapiens) 		PF00076
(RRM_1)
PF05383
(La) 		4 PHE A 145
ARG A 143
ASN A 137
LEU A  83
 None
 1.30A 2nyrA-4wkrA:
undetectable		 2nyrA-4wkrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 PHE A 181
GLN A 234
ASN A 115
LEU A 118
 PCA  A   1 ( 3.5A)
None
None
None
 1.06A 2nyrA-4zzqA:
undetectable		 2nyrA-4zzqA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 PHE A 414
GLN A 281
ASN A 409
LEU A 439
 None
 1.26A 2nyrA-5c65A:
undetectable		 2nyrA-5c65A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzw PROTOCADHERIN
ALPHA-4

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 PHE A 112
ARG A 117
ASN A 209
LEU A 301
 None
None
CA  A 509 ( 3.7A)
None
 1.27A 2nyrA-5dzwA:
undetectable		 2nyrA-5dzwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 ARG B 371
GLN B 390
ASN B  94
LEU B  85
 None
NAG  B3094 ( 4.5A)
NAG  B3094 (-1.9A)
None
 1.00A 2nyrA-5e6sB:
2.2		 2nyrA-5e6sB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6v INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin) 		4 ARG A 371
GLN A 390
ASN A  94
LEU A  85
 NAG  A 501 (-3.5A)
NAG  A 502 (-3.8A)
NAG  A 502 (-1.8A)
None
 0.76A 2nyrA-5e6vA:
undetectable		 2nyrA-5e6vA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		no annotation 4 GLN A 453
ASN A 457
ASN A 317
LEU A 389
 None
 1.12A 2nyrA-5e7gA:
undetectable		 2nyrA-5e7gA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		4 GLN A 453
ASN A 457
ASN A 317
LEU A 389
 None
 1.10A 2nyrA-5e7hA:
undetectable		 2nyrA-5e7hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		4 ARG A 541
GLN A 483
ASN A 482
LEU A 404
 None
None
MN  A1000 (-3.3A)
None
 1.28A 2nyrA-5fx8A:
undetectable		 2nyrA-5fx8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		4 GLN A 334
ASN A 342
ASN A 253
LEU A 298
 None
None
FAD  A 602 (-4.6A)
FAD  A 602 ( 3.8A)
 1.28A 2nyrA-5glgA:
2.7		 2nyrA-5glgA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		4 PHE A 359
ARG A 360
ASN A 262
ASN A 346
 None
 1.21A 2nyrA-5h0iA:
4.3		 2nyrA-5h0iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 PHE A  19
ARG B1215
ASN B1211
LEU A  58
 None
 1.21A 2nyrA-5ip9A:
undetectable		 2nyrA-5ip9A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ARG A 400
GLN A 220
ASN A 337
LEU A 228
 None
 1.18A 2nyrA-5jxrA:
undetectable		 2nyrA-5jxrA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj4 PROTOCADHERIN-15

(Mus musculus) 		PF00028
(Cadherin) 		4 ARG A1085
GLN A1087
ASN A1105
ASN A1062
 None
 1.31A 2nyrA-5kj4A:
undetectable		 2nyrA-5kj4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knh DARPIN 6G9

(synthetic
construct) 		PF12796
(Ank_2) 		4 GLN D 122
ASN D 156
ASN D 107
LEU D 132
 ACT  D1001 (-2.9A)
None
None
None
 1.21A 2nyrA-5knhD:
undetectable		 2nyrA-5knhD:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 PHE A 238
ARG A 239
ASN A 333
LEU A 252
 None
 1.04A 2nyrA-5l9wA:
undetectable		 2nyrA-5l9wA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A 426
ARG A 382
ASN A 593
LEU A 619
 None
None
SO4  A1005 ( 4.0A)
None
 1.13A 2nyrA-5lewA:
undetectable		 2nyrA-5lewA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6q UNCHARACTERIZED
PROTEIN

(Kutzneria
albida) 		PF09017
(Transglut_prok) 		4 GLN A  78
ASN A  82
ASN A 109
LEU A 107
 None
None
MES  A 301 ( 3.8A)
None
 1.26A 2nyrA-5m6qA:
undetectable		 2nyrA-5m6qA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3

(Saccharomyces
cerevisiae) 		PF05327
(RRN3) 		4 PHE O 528
ARG O 530
ASN O 523
ASN O 549
 None
 1.22A 2nyrA-5n5zO:
undetectable		 2nyrA-5n5zO:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG W 597
GLN W 410
ASN W 536
LEU W 418
 None
 1.26A 2nyrA-5o9gW:
undetectable		 2nyrA-5o9gW:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 4 PHE A 546
GLN A 320
ASN A 249
LEU A 305
 None
 1.29A 2nyrA-5oatA:
undetectable		 2nyrA-5oatA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 4 PHE A 440
ARG A 395
ASN A 434
LEU A 388
 None
None
XYS  A 505 ( 4.1A)
None
 1.13A 2nyrA-5oydA:
undetectable		 2nyrA-5oydA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2n I-ONUI_E-AG007820

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 PHE A 181
GLN A 197
ASN A 184
LEU A 282
 None
 1.24A 2nyrA-5t2nA:
undetectable		 2nyrA-5t2nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2n I-ONUI_E-AG007820

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 PHE A 200
GLN A 197
ASN A 184
LEU A 282
 None
 0.98A 2nyrA-5t2nA:
undetectable		 2nyrA-5t2nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 ARG C 301
GLN C 377
ASN C 378
LEU C 124
 None
 1.12A 2nyrA-5tw1C:
undetectable		 2nyrA-5tw1C:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		4 PHE A1580
ARG A1579
ASN A1552
ASN A1588
 None
 1.27A 2nyrA-5xjyA:
undetectable		 2nyrA-5xjyA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 4 GLN A 498
ASN A 532
ASN A 519
LEU A 483
 None
 1.28A 2nyrA-5y09A:
undetectable		 2nyrA-5y09A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT
ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 PHE C 296
ARG C 204
ASN C 130
ASN B 146
 None
 1.29A 2nyrA-5y6qC:
undetectable		 2nyrA-5y6qC:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14

(Arabidopsis
thaliana) 		no annotation 4 ARG A 369
GLN A 122
ASN A 123
LEU A 359
 None
 1.20A 2nyrA-5yknA:
undetectable		 2nyrA-5yknA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 4 ARG A 846
GLN A1383
ASN A1375
ASN A1296
 None
 1.06A 2nyrA-5yudA:
undetectable		 2nyrA-5yudA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 4 ARG A 846
GLN A1383
ASN A1375
LEU A1359
 None
 1.04A 2nyrA-5yudA:
undetectable		 2nyrA-5yudA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 4 GLN A 589
ASN A 927
ASN A 899
LEU A 736
 None
 1.15A 2nyrA-6bfuA:
undetectable		 2nyrA-6bfuA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 4 ARG A  47
GLN A 239
ASN A 241
LEU A 205
 None
 1.30A 2nyrA-6c29A:
undetectable		 2nyrA-6c29A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnj NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2

(Homo sapiens) 		no annotation 4 PHE B 139
ARG B 207
GLN B 142
LEU B 183
 None
 1.28A 2nyrA-6cnjB:
undetectable		 2nyrA-6cnjB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A2155
ARG A2156
ASN A1585
LEU A 848
 None
 1.20A 2nyrA-6emkA:
undetectable		 2nyrA-6emkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A  41
ASN A 412
ASN A 430
LEU A 501
 None
 1.30A 2nyrA-6eojA:
undetectable		 2nyrA-6eojA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus) 		no annotation 4 PHE C 137
GLN C 548
ASN C 549
LEU C 677
 None
 1.15A 2nyrA-6f5oC:
undetectable		 2nyrA-6f5oC:
15.97