SIMILAR PATTERNS OF AMINO ACIDS FOR 2NYR_B_SVRB401_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8x | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE H (Streptomycesplicatus) |
PF00704(Glyco_hydro_18) | 5 | ALA A 45ALA A 173TYR A 136ILE A 48LEU A 156 | ALA A 45 ( 0.0A)ALA A 173 ( 0.0A)TYR A 136 ( 1.3A)ILE A 48 ( 0.6A)LEU A 156 ( 0.6A) | 1.05A | 2nyrA-1c8xA:undetectable | 2nyrA-1c8xA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpc | C-PHYCOCYANIN (ALPHASUBUNIT) (Microchaetediplosiphon) |
PF00502(Phycobilisome) | 5 | THR A 96ALA A 52ALA A 55ILE A 166LEU A 173 | None | 1.15A | 2nyrA-1cpcA:undetectable | 2nyrA-1cpcA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d4e | FLAVOCYTOCHROME CFUMARATE REDUCTASE (Shewanellaoneidensis) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 5 | ALA A 532THR A 536ALA A 353ALA A 351ILE A 131 | NoneNoneNoneNoneFAD A 600 ( 4.7A) | 0.99A | 2nyrA-1d4eA:2.6 | 2nyrA-1d4eA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbi | AK.1 SERINE PROTEASE (Bacillus sp.Ak1) |
PF00082(Peptidase_S8) | 5 | ALA A 205THR A 18ALA A 94ALA A 237ILE A 253 | None | 1.21A | 2nyrA-1dbiA:undetectable | 2nyrA-1dbiA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evl | THREONYL-TRNASYNTHETASE (Escherichiacoli) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 5 | ALA A 565ALA A 538ILE A 632LEU A 640MET A 619 | None | 1.02A | 2nyrA-1evlA:undetectable | 2nyrA-1evlA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khw | RNA-DIRECTED RNAPOLYMERASE (Rabbithemorrhagicdisease virus) |
PF00680(RdRP_1) | 5 | ALA A 492ALA A 461ARG A 499PHE A 468LEU A 426 | None | 1.04A | 2nyrA-1khwA:undetectable | 2nyrA-1khwA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mpt | M-PROTEASE (Bacillusclausii) |
PF00082(Peptidase_S8) | 5 | ALA A 223ALA A 270ALA A 273ILE A 198LEU A 148 | None | 1.15A | 2nyrA-1mptA:undetectable | 2nyrA-1mptA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nl3 | PREPROTEINTRANSLOCASE SECA 1SUBUNIT (Mycobacteriumtuberculosis) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 5 | ALA A 135THR A 129ALA A 205PHE A 362TYR A 361 | None | 1.01A | 2nyrA-1nl3A:undetectable | 2nyrA-1nl3A:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qf6 | THREONYL-TRNASYNTHETASE (Escherichiacoli) |
PF00587(tRNA-synt_2b)PF02824(TGS)PF03129(HGTP_anticodon)PF07973(tRNA_SAD) | 5 | ALA A 565ALA A 538ILE A 632LEU A 640MET A 619 | None | 1.11A | 2nyrA-1qf6A:undetectable | 2nyrA-1qf6A:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qup | SUPEROXIDE DISMUTASE1 COPPER CHAPERONE (Saccharomycescerevisiae) |
PF00080(Sod_Cu)PF00403(HMA) | 5 | ALA A 80THR A 182ALA A 178ILE A 70PHE A 153 | None | 1.15A | 2nyrA-1qupA:undetectable | 2nyrA-1qupA:23.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s5p | NAD-DEPENDENTDEACETYLASE (Escherichiacoli) |
PF02146(SIR2) | 6 | ALA A 49THR A 59ALA A 76PHE A 91TYR A 92ILE A 131 | None | 0.90A | 2nyrA-1s5pA:18.8 | 2nyrA-1s5pA:36.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s5p | NAD-DEPENDENTDEACETYLASE (Escherichiacoli) |
PF02146(SIR2) | 6 | THR A 59ALA A 76PHE A 91TYR A 92ILE A 131PHE A 190 | None | 0.93A | 2nyrA-1s5pA:18.8 | 2nyrA-1s5pA:36.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve1 | O-ACETYLSERINESULFHYDRYLASE (Thermusthermophilus) |
PF00291(PALP) | 5 | ALA A 127THR A 91ALA A 109ALA A 78LEU A 57 | None | 1.16A | 2nyrA-1ve1A:2.8 | 2nyrA-1ve1A:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xfk | FORMIMIDOYLGLUTAMASE (Vibrio cholerae) |
PF00491(Arginase) | 5 | ALA A 323ALA A 75ALA A 312ILE A 298LEU A 276 | None | 1.04A | 2nyrA-1xfkA:3.8 | 2nyrA-1xfkA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ygp | YEAST GLYCOGENPHOSPHORYLASE (Saccharomycescerevisiae) |
PF00343(Phosphorylase) | 5 | ALA A 223ALA A 302PHE A 298LEU A 87TYR A 161 | None | 1.10A | 2nyrA-1ygpA:undetectable | 2nyrA-1ygpA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yrz | XYLANBETA-1,4-XYLOSIDASE (Bacillushalodurans) |
PF04616(Glyco_hydro_43) | 5 | ALA A1264THR A1282ILE A1005LEU A1313TYR A1026 | None | 1.19A | 2nyrA-1yrzA:undetectable | 2nyrA-1yrzA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 5 | THR A 339ALA A 342ALA A 355ILE A 456LEU A 441 | None | 1.08A | 2nyrA-1zfjA:undetectable | 2nyrA-1zfjA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ayn | UBIQUITINCARBOXYL-TERMINALHYDROLASE 14 (Homo sapiens) |
PF00443(UCH) | 5 | ALA A 131ALA A 321ALA A 406ILE A 217PHE A 405 | None | 1.07A | 2nyrA-2aynA:undetectable | 2nyrA-2aynA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gou | OXIDOREDUCTASE,FMN-BINDING (Shewanellaoneidensis) |
PF00724(Oxidored_FMN) | 5 | ALA A 182ALA A 167ALA A 170LEU A 53TYR A 266 | None | 1.18A | 2nyrA-2gouA:undetectable | 2nyrA-2gouA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipc | PREPROTEINTRANSLOCASE SECASUBUNIT (Thermusthermophilus) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 5 | THR A 119ALA A 112TYR A 144LEU A 179TYR A 378 | None | 0.91A | 2nyrA-2ipcA:2.2 | 2nyrA-2ipcA:14.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixm | SERINE/THREONINE-PROTEIN PHOSPHATASE 2AREGULATORY SUBUNITB' (Homo sapiens) |
PF03095(PTPA) | 5 | THR A 153ALA A 160PHE A 185ILE A 221TYR A 45 | None | 1.20A | 2nyrA-2ixmA:undetectable | 2nyrA-2ixmA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o2a | HYPOTHETICAL PROTEINGBS1413 (Streptococcusagalactiae) |
PF06619(DUF1149) | 5 | ALA A 0ALA A 96ALA A 53ARG A 5ILE A 76 | None | 1.16A | 2nyrA-2o2aA:undetectable | 2nyrA-2o2aA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o7r | CXE CARBOXYLESTERASE (Actinidiaeriantha) |
PF07859(Abhydrolase_3) | 5 | ALA A 139ALA A 178ILE A 194PHE A 89MET A 111 | None | 1.20A | 2nyrA-2o7rA:2.2 | 2nyrA-2o7rA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oew | PROGRAMMED CELLDEATH 6-INTERACTINGPROTEIN (Homo sapiens) |
PF03097(BRO1) | 5 | ALA A 170THR A 166ALA A 159ALA A 128ILE A 179 | None | 1.15A | 2nyrA-2oewA:undetectable | 2nyrA-2oewA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1y | CELL DIVISIONPROTEIN FTSZ (Mycobacteriumtuberculosis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | ALA A 309ALA A 238ALA A 275ILE A 289LEU A 197 | None | 1.18A | 2nyrA-2q1yA:6.1 | 2nyrA-2q1yA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r62 | CELL DIVISIONPROTEASE FTSHHOMOLOG (Helicobacterpylori) |
PF00004(AAA) | 5 | ALA A 316ALA A 315ILE A 274PHE A 267LEU A 254 | None | 1.08A | 2nyrA-2r62A:undetectable | 2nyrA-2r62A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vda | TRANSLOCASE SUBUNITSECA (Escherichiacoli) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 5 | ALA A 136THR A 130ALA A 206PHE A 381TYR A 380 | None | 1.16A | 2nyrA-2vdaA:2.3 | 2nyrA-2vdaA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3z | PUTATIVE DEACETYLASE (Streptococcusmutans) |
PF01522(Polysacc_deac_1) | 5 | THR A 207ALA A 87ALA A 83ILE A 157LEU A 126 | None | 1.14A | 2nyrA-2w3zA:undetectable | 2nyrA-2w3zA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xcm | CYTOSOLIC HEAT SHOCKPROTEIN 90 (Hordeum vulgare) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | THR A 139ALA A 129PHE A 126ILE A 79LEU A 187 | None | 1.06A | 2nyrA-2xcmA:undetectable | 2nyrA-2xcmA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjn | DTDP-4-KETO-6-DEOXY-HEXOSE 3,4-ISOMERASE (Saccharopolysporaerythraea) |
PF00067(p450) | 5 | THR B 88ALA B 299ALA B 298LEU B 196TYR B 50 | None | 1.15A | 2nyrA-2yjnB:undetectable | 2nyrA-2yjnB:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z04 | PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASEATPASE SUBUNIT (Aquifexaeolicus) |
PF02222(ATP-grasp) | 5 | ALA A 252THR A 235ALA A 277ILE A 230LEU A 80 | None | 0.98A | 2nyrA-2z04A:4.9 | 2nyrA-2z04A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b96 | VERY LONG-CHAINSPECIFIC ACYL-COADEHYDROGENASE (Homo sapiens) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ALA A 376ALA A 293PHE A 174PHE A 290MET A 438 | NoneNoneMYA A 1 (-4.8A)NoneNone | 1.22A | 2nyrA-3b96A:undetectable | 2nyrA-3b96A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjd | PUTATIVE3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE (Pseudomonasaeruginosa) |
PF14515(HOASN)PF14518(Haem_oxygenas_2) | 5 | ALA A 173ALA A 238PHE A 298ARG A 292LEU A 154 | None | 1.20A | 2nyrA-3bjdA:undetectable | 2nyrA-3bjdA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bn1 | PEROSAMINESYNTHETASE (Caulobactervibrioides) |
PF01041(DegT_DnrJ_EryC1) | 5 | ALA A 178ALA A 158PHE A 180LEU A 251TYR A 48 | None | 0.96A | 2nyrA-3bn1A:undetectable | 2nyrA-3bn1A:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bwm | CATECHOLO-METHYLTRANSFERASE (Homo sapiens) |
PF01596(Methyltransf_3) | 5 | ALA A 67THR A 99ALA A 106ALA A 22MET A 137 | None | 1.07A | 2nyrA-3bwmA:4.7 | 2nyrA-3bwmA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c2u | XYLOSIDASE/ARABINOSIDASE (Selenomonasruminantium) |
PF04616(Glyco_hydro_43)PF07081(DUF1349) | 5 | ALA A 262THR A 292ILE A 3LEU A 321TYR A 24 | None | 1.19A | 2nyrA-3c2uA:undetectable | 2nyrA-3c2uA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbs | OXIDOREDUCTASE (Agrobacteriumfabrum) |
PF07992(Pyr_redox_2) | 5 | ALA A 267THR A 249ALA A 286ALA A 287LEU A 30 | None | 1.15A | 2nyrA-3fbsA:3.3 | 2nyrA-3fbsA:24.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4p | PROTEASOME SUBUNITBETA (Methanocaldococcusjannaschii) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 5 | ALA a 52THR a 7ALA a 143ALA a 167LEU a 118 | None | 1.14A | 2nyrA-3h4pa:undetectable | 2nyrA-3h4pa:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib3 | COCE/NOND FAMILYHYDROLASE (Staphylococcusaureus) |
PF02129(Peptidase_S15)PF08530(PepX_C) | 5 | ALA A 73THR A 174ALA A 188ILE A 150PHE A 316 | None | 1.03A | 2nyrA-3ib3A:undetectable | 2nyrA-3ib3A:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jux | PROTEIN TRANSLOCASESUBUNIT SECA (Thermotogamaritima) |
PF00271(Helicase_C)PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 5 | ALA A 129THR A 123ALA A 249PHE A 406TYR A 405 | None | 1.15A | 2nyrA-3juxA:undetectable | 2nyrA-3juxA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lca | PROTEIN TOM71 (Saccharomycescerevisiae) |
PF00515(TPR_1)PF13181(TPR_8)PF14559(TPR_19) | 5 | ALA A 364THR A 387PHE A 401PHE A 276LEU A 346 | None | 1.17A | 2nyrA-3lcaA:undetectable | 2nyrA-3lcaA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llx | PREDICTED AMINO ACIDALDOLASE OR RACEMASE (Idiomarinaloihiensis) |
PF01168(Ala_racemase_N)PF14031(D-ser_dehydrat) | 5 | ALA A 194ALA A 158ILE A 147PHE A 165LEU A 111 | None | 1.16A | 2nyrA-3llxA:undetectable | 2nyrA-3llxA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgz | 3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATESYNTHASE (Mycobacteriumtuberculosis) |
PF00926(DHBP_synthase) | 5 | ALA A 92THR A 107ALA A 38ALA A 160LEU A 71 | None | 1.09A | 2nyrA-3mgzA:undetectable | 2nyrA-3mgzA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0t | DIPEPTIDYL PEPTIDASE2 (Homo sapiens) |
PF05577(Peptidase_S28) | 5 | ALA A 310ALA A 262ILE A 303PHE A 261LEU A 249 | None | 1.10A | 2nyrA-3n0tA:undetectable | 2nyrA-3n0tA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0t | DIPEPTIDYL PEPTIDASE2 (Homo sapiens) |
PF05577(Peptidase_S28) | 5 | THR A 304ALA A 310ALA A 262ILE A 227PHE A 261 | None | 1.08A | 2nyrA-3n0tA:undetectable | 2nyrA-3n0tA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2t | PUTATIVEOXIDOREDUCTASE (Gluconobacteroxydans) |
PF00248(Aldo_ket_red) | 5 | THR A 13ALA A 156ALA A 177ILE A 6LEU A 281 | None | 1.21A | 2nyrA-3n2tA:undetectable | 2nyrA-3n2tA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oit | OS07G0271500 PROTEIN (Oryza sativa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | ALA A 180THR A 140ALA A 116ALA A 119ILE A 356 | None | 1.04A | 2nyrA-3oitA:undetectable | 2nyrA-3oitA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3omn | CYTOCHROME COXIDASE, AA3 TYPE,SUBUNIT I (Rhodobactersphaeroides) |
PF00115(COX1) | 5 | ALA A 134THR A 210ALA A 236ILE A 128PHE A 116 | None | 1.07A | 2nyrA-3omnA:undetectable | 2nyrA-3omnA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oqp | PUTATIVEISOCHORISMATASE (Paraburkholderiaxenovorans) |
PF00857(Isochorismatase) | 5 | ALA A 39THR A 178ALA A 174ALA A 173LEU A 103 | None | 1.18A | 2nyrA-3oqpA:6.0 | 2nyrA-3oqpA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qki | GLUCOSE-6-PHOSPHATEISOMERASE (Plasmodiumfalciparum) |
PF00342(PGI) | 5 | THR A 507ALA A 169PHE A 165ILE A 428LEU A 450 | None | 1.20A | 2nyrA-3qkiA:3.6 | 2nyrA-3qkiA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qp9 | TYPE I POLYKETIDESYNTHASE PIKAII (Streptomycesvenezuelae) |
PF08659(KR) | 5 | ALA A 94ALA A 179ALA A 183ILE A 173LEU A 50 | None | 1.21A | 2nyrA-3qp9A:3.0 | 2nyrA-3qp9A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qtp | ENOLASE 1 (Entamoebahistolytica) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ALA A 228THR A 186ALA A 401ILE A 194LEU A 161 | None | 1.19A | 2nyrA-3qtpA:undetectable | 2nyrA-3qtpA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tdu | DCN1-LIKE PROTEIN 1 (Homo sapiens) |
PF03556(Cullin_binding) | 5 | ALA A 106ALA A 111PHE A 117PHE A 160LEU A 173 | None | 1.20A | 2nyrA-3tduA:undetectable | 2nyrA-3tduA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqk | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Francisellatularensis) |
PF00793(DAHP_synth_1) | 5 | ALA A 49ALA A 181ALA A 208PHE A 190LEU A 259 | None | 1.19A | 2nyrA-3tqkA:undetectable | 2nyrA-3tqkA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wqu | CELL DIVISIONPROTEIN FTSA (Staphylococcusaureus) |
PF02491(SHS2_FTSA)PF14450(FtsA) | 5 | ALA A 362THR A 365ALA A 215TYR A 217ILE A 192 | None | 1.15A | 2nyrA-3wquA:undetectable | 2nyrA-3wquA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zgj | 4-HYDROXYPHENYLPYRUVIC ACID DIOXYGENASE (Streptomycescoelicolor) |
PF00903(Glyoxalase)PF14696(Glyoxalase_5) | 5 | ALA A 109ALA A 201ILE A 231PHE A 197LEU A 235 | None | 1.22A | 2nyrA-3zgjA:undetectable | 2nyrA-3zgjA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zgj | 4-HYDROXYPHENYLPYRUVIC ACID DIOXYGENASE (Streptomycescoelicolor) |
PF00903(Glyoxalase)PF14696(Glyoxalase_5) | 5 | THR A 134ALA A 114PHE A 202TYR A 198ILE A 141 | None | 1.20A | 2nyrA-3zgjA:undetectable | 2nyrA-3zgjA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4em6 | GLUCOSE-6-PHOSPHATEISOMERASE (Brucellamelitensis) |
no annotation | 5 | ALA D 236ALA D 221ALA D 218ILE D 253LEU D 277 | None | 1.14A | 2nyrA-4em6D:3.8 | 2nyrA-4em6D:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evz | HISF-LUCA (syntheticconstruct) |
PF00977(His_biosynth) | 5 | ALA A 221ALA A 222PHE A 214ILE A 235LEU A 10 | None | 1.02A | 2nyrA-4evzA:undetectable | 2nyrA-4evzA:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdd | TRANSPORTIN-1 (Homo sapiens) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 5 | ALA A 505THR A 547ILE A 522PHE A 530LEU A 490 | None | 1.10A | 2nyrA-4fddA:undetectable | 2nyrA-4fddA:15.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g1c | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 7 | ALA A 59THR A 69ALA A 86PHE A 101TYR A 102ILE A 142LEU A 227 | CNA A 402 (-3.0A)CNA A 402 (-3.8A)NoneNoneNoneCNA A 402 (-4.7A)None | 0.88A | 2nyrA-4g1cA:37.7 | 2nyrA-4g1cA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g1c | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 6 | THR A 69ALA A 82ALA A 86TYR A 102ILE A 142LEU A 227 | CNA A 402 (-3.8A)NoneNoneNoneCNA A 402 (-4.7A)None | 1.07A | 2nyrA-4g1cA:37.7 | 2nyrA-4g1cA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g1c | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 7 | THR A 69ALA A 86PHE A 101TYR A 102ILE A 142PHE A 223LEU A 227 | CNA A 402 (-3.8A)NoneNoneNoneCNA A 402 (-4.7A)NoneNone | 0.95A | 2nyrA-4g1cA:37.7 | 2nyrA-4g1cA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gao | DCN1-LIKE PROTEIN 2 (Homo sapiens) |
PF03556(Cullin_binding) | 5 | ALA A 106ALA A 111PHE A 117PHE A 160LEU A 173 | None | 1.21A | 2nyrA-4gaoA:undetectable | 2nyrA-4gaoA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gqt | HEAT SHOCK PROTEIN90 (Caenorhabditiselegans) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | THR A 139ALA A 129PHE A 126ILE A 79LEU A 186 | None | 1.05A | 2nyrA-4gqtA:undetectable | 2nyrA-4gqtA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k1p | NHEA (Bacillus cereus) |
PF05791(Bacillus_HBL) | 5 | ALA A 189THR A 192ALA A 37ILE A 252LEU A 259 | None | 1.04A | 2nyrA-4k1pA:undetectable | 2nyrA-4k1pA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdi | UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE (Acinetobacterbaumannii) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | ALA A 407ALA A 354ALA A 353ARG A 351ILE A 371 | None | 0.98A | 2nyrA-4qdiA:3.5 | 2nyrA-4qdiA:20.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twi | NAD-DEPENDENTPROTEIN DEACYLASE 1 (Archaeoglobusfulgidus) |
PF02146(SIR2) | 5 | ALA A 21THR A 31ALA A 48TYR A 64LEU A 163 | None | 1.03A | 2nyrA-4twiA:27.5 | 2nyrA-4twiA:39.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twi | NAD-DEPENDENTPROTEIN DEACYLASE 1 (Archaeoglobusfulgidus) |
PF02146(SIR2) | 5 | THR A 31ALA A 48TYR A 64PHE A 159LEU A 163 | None | 1.12A | 2nyrA-4twiA:27.5 | 2nyrA-4twiA:39.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x3m | RNA 2'-O RIBOSEMETHYLTRANSFERASE (Thermusthermophilus) |
PF00588(SpoU_methylase) | 5 | ALA A 186THR A 242ALA A 130ALA A 135LEU A 176 | ADN A 301 ( 4.1A)ADN A 301 (-3.5A)NoneNoneNone | 1.05A | 2nyrA-4x3mA:3.1 | 2nyrA-4x3mA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9l | HEAT SHOCK PROTEIN (Oryza sativa) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | THR A 139ALA A 129PHE A 126ILE A 79LEU A 187 | PG4 A 302 ( 4.2A)NoneNoneNoneNone | 1.12A | 2nyrA-4x9lA:undetectable | 2nyrA-4x9lA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xq7 | 2'-5'-OLIGOADENYLATESYNTHASE-LIKEPROTEIN (Homo sapiens) |
PF10421(OAS1_C) | 5 | ALA A 243THR A 262ALA A 326ALA A 323ILE A 273 | None | 1.13A | 2nyrA-4xq7A:undetectable | 2nyrA-4xq7A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xr9 | CALS8 (Micromonosporaechinospora) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | ALA A 20THR A 25ALA A 32ALA A 36ILE A 92 | None | 0.95A | 2nyrA-4xr9A:4.1 | 2nyrA-4xr9A:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yji | ARYL ACYLAMIDASE (bacteriumCSBL00001) |
PF01425(Amidase) | 5 | ALA A 168THR A 197ALA A 13LEU A 127TYR A 116 | None | 1.21A | 2nyrA-4yjiA:undetectable | 2nyrA-4yjiA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zze | SUGAR BINDINGPROTEIN OF ABCTRANSPORTER SYSTEM (Bifidobacteriumanimalis) |
PF01547(SBP_bac_1) | 5 | ALA A 312THR A 228ALA A 166PHE A 307MET A 196 | None | 1.21A | 2nyrA-4zzeA:undetectable | 2nyrA-4zzeA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bn4 | V-TYPE ATP SYNTHASEALPHA CHAIN (Nanoarchaeumequitans) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N)PF16886(ATP-synt_ab_Xtn) | 5 | ALA A 237PHE A 356TYR A 357ILE A 376LEU A 404 | None | 1.07A | 2nyrA-5bn4A:undetectable | 2nyrA-5bn4A:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fp1 | TONB-DEPENDENTSIDEROPHORE RECEPTOR (Acinetobacterbaumannii) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ALA A 290ALA A 201ALA A 110ILE A 95PHE A 109 | None | 1.19A | 2nyrA-5fp1A:undetectable | 2nyrA-5fp1A:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fv4 | CARBOXYLIC ESTERHYDROLASE (Sus scrofa) |
PF00135(COesterase) | 5 | ALA A 421ALA A 219ILE A 317PHE A 223TYR A 328 | None | 1.17A | 2nyrA-5fv4A:undetectable | 2nyrA-5fv4A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hql | RIBULOSEBISPHOSPHATECARBOXYLASE (Rhodopseudomonaspalustris) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ALA A 215ALA A 405ALA A 408ILE A 191LEU A 151 | NoneNoneNoneKCX A 192 ( 3.8A)None | 1.11A | 2nyrA-5hqlA:undetectable | 2nyrA-5hqlA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i4k | MANGANESE-BINDINGLIPOPROTEIN MNTA (Listeriamonocytogenes) |
PF01297(ZnuA) | 5 | ALA A 284ALA A 208ILE A 41PHE A 209LEU A 145 | None MN A 501 ( 4.6A)NoneNoneNone | 1.00A | 2nyrA-5i4kA:undetectable | 2nyrA-5i4kA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ito | NOPALINE-BINDINGPERIPLASMIC PROTEIN (Agrobacteriumfabrum) |
PF00497(SBP_bac_3) | 5 | THR A 168PHE A 108ARG A 102ILE A 80LEU A 51 | 6DB A 304 ( 4.1A)None6DB A 304 (-2.8A)NoneNone | 1.21A | 2nyrA-5itoA:undetectable | 2nyrA-5itoA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9t | PROTEIN TRANSLOCASESUBUNIT SECA (Escherichiacoli) |
PF01043(SecA_PP_bind)PF07517(SecA_DEAD) | 5 | ALA A 136THR A 130ALA A 206PHE A 381TYR A 380 | None | 1.18A | 2nyrA-5k9tA:2.4 | 2nyrA-5k9tA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kyu | PROTEIN TRANSPORTPROTEIN SEC24D (Homo sapiens) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 5 | THR B 298ALA B 880ILE B 302LEU B 766TYR B 318 | None | 1.19A | 2nyrA-5kyuB:3.2 | 2nyrA-5kyuB:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lp7 | ACETYL-COAACETYLTRANSFERASE (Bacillussubtilis) |
no annotation | 5 | ALA H 376ALA H 353PHE H 14ARG H 357LEU H 259 | None | 1.18A | 2nyrA-5lp7H:undetectable | 2nyrA-5lp7H:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd1 | CAPSID PROTEIN (Rosellinianecatrixquadrivirus 1) |
no annotation | 5 | ALA A 779ALA A 761ALA A 763ILE A 787LEU A 846 | None | 1.18A | 2nyrA-5nd1A:undetectable | 2nyrA-5nd1A:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2m | MEVALONATEDIPHOSPHATEDECARBOXYLASE (Enterococcusfaecalis) |
no annotation | 5 | ALA A 104THR A 10ALA A 150ALA A 163MET A 195 | NoneNoneNoneNoneSO4 A 401 ( 4.4A) | 1.12A | 2nyrA-5v2mA:undetectable | 2nyrA-5v2mA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wkh | T-CELL RECEPTORALPHA VARIABLE30,T-CELL RECEPTOR,SP3.4 ALPHA CHAIN (Homo sapiens) |
PF07686(V-set)PF09291(DUF1968) | 5 | ALA D 130THR D 148ALA D 186ILE D 204PHE D 193 | None | 1.13A | 2nyrA-5wkhD:undetectable | 2nyrA-5wkhD:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wy3 | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
no annotation | 5 | ALA A 129ALA A 121TYR A 168PHE A 239LEU A 260 | None | 1.14A | 2nyrA-5wy3A:undetectable | 2nyrA-5wy3A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xde | THERMOPHILICDIBENZOTHIOPHENEDESULFURIZATIONENZYME C (Paenibacillussp. A11-2) |
PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N)PF08028(Acyl-CoA_dh_2) | 5 | ALA A 81ALA A 313ALA A 317ILE A 254LEU A 57 | None | 1.20A | 2nyrA-5xdeA:undetectable | 2nyrA-5xdeA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xk2 | DIACYLGLYCEROLLIPASE (Aspergillusoryzae) |
no annotation | 5 | ALA A 116ALA A 180ALA A 177ILE A 192LEU A 166 | None | 1.14A | 2nyrA-5xk2A:undetectable | 2nyrA-5xk2A:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xqo | PCRGLX PROTEIN (Penicilliumchrysogenum) |
no annotation | 5 | THR A 738ALA A 745ALA A 811PHE A 751ILE A 797 | None | 1.13A | 2nyrA-5xqoA:undetectable | 2nyrA-5xqoA:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ysm | CYTOCHROME P450 (Amycolatopsismediterranei) |
no annotation | 5 | THR A 242ALA A 237ALA A 235ILE A 228LEU A 367 | NoneNoneNoneNoneHEM A 501 ( 4.2A) | 1.12A | 2nyrA-5ysmA:undetectable | 2nyrA-5ysmA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bwy | DU-EDITING ENZYMEAPOBEC-3G FUSIONPROTECTION OFTELOMERES PROTEIN 1,DNA DC-> (Homo sapiens;Schizosaccharomycespombe) |
no annotation | 5 | ALA A 296THR A 327ALA A 321ILE A 335LEU A 220 | None | 1.20A | 2nyrA-6bwyA:undetectable | 2nyrA-6bwyA:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cv0 | SPIKE GLYCOPROTEIN (Aviancoronavirus) |
no annotation | 5 | THR A 682ALA A 756ALA A 759ILE A 677PHE A 760 | None | 1.04A | 2nyrA-6cv0A:undetectable | 2nyrA-6cv0A:16.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 6 | ALA A 55ALA A 78ALA A 82TYR A 98PHE A 219LEU A 223 | BJW A 303 (-3.5A)NoneBJW A 303 ( 4.7A)BJW A 303 (-4.4A)BJW A 303 (-4.1A)None | 1.04A | 2nyrA-6enxA:34.5 | 2nyrA-6enxA:74.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 6 | ALA A 55ALA A 82TYR A 98ILE A 138PHE A 219LEU A 223 | BJW A 303 (-3.5A)BJW A 303 ( 4.7A)BJW A 303 (-4.4A)BJW A 303 (-3.9A)BJW A 303 (-4.1A)None | 0.82A | 2nyrA-6enxA:34.5 | 2nyrA-6enxA:74.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 5 | ALA A 55THR A 65ALA A 82TYR A 98PHE A 219 | BJW A 303 (-3.5A)BJW A 303 (-4.0A)BJW A 303 ( 4.7A)BJW A 303 (-4.4A)BJW A 303 (-4.1A) | 0.94A | 2nyrA-6enxA:34.5 | 2nyrA-6enxA:74.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 6 | ALA A 82PHE A 97TYR A 98ILE A 138PHE A 219LEU A 223 | BJW A 303 ( 4.7A)NoneBJW A 303 (-4.4A)BJW A 303 (-3.9A)BJW A 303 (-4.1A)None | 0.43A | 2nyrA-6enxA:34.5 | 2nyrA-6enxA:74.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 5 | THR A 65ALA A 82PHE A 97TYR A 98PHE A 219 | BJW A 303 (-4.0A)BJW A 303 ( 4.7A)NoneBJW A 303 (-4.4A)BJW A 303 (-4.1A) | 0.62A | 2nyrA-6enxA:34.5 | 2nyrA-6enxA:74.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eom | MUTT/NUDIX FAMILYPROTEIN (Caldithrixabyssi) |
no annotation | 5 | THR A 231ALA A 196ALA A 192ILE A 257LEU A 554 | CL A 602 (-4.6A)NoneNoneNoneNone | 1.11A | 2nyrA-6eomA:undetectable | 2nyrA-6eomA:13.96 |