SIMILAR PATTERNS OF AMINO ACIDS FOR 2NV4_B_SAMB202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)

(Serratia
marcescens) 		PF00583
(Acetyltransf_1) 		5 ALA A  92
GLN A 145
TYR A  57
ASP A  45
ASP A 110
 None
SPD  A 200 (-3.8A)
None
None
SPD  A 200 (-3.3A)
 1.30A 2nv4B-1bo4A:
0.0		 2nv4B-1bo4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crk CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 GLN A  53
TYR A  46
GLY A  72
LEU A 137
SER A  47
 None
 1.02A 2nv4B-1crkA:
0.0		 2nv4B-1crkA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dow ALPHA-CATENIN

(Mus musculus) 		PF01044
(Vinculin) 		5 ALA A  93
GLY A 101
LEU A 103
ASP A  96
LEU A 138
 None
 1.28A 2nv4B-1dowA:
undetectable		 2nv4B-1dowA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLN A 115
ALA A  97
LEU A 131
ASP A 133
LEU A  94
 None
ZN  A 344 ( 4.6A)
None
None
None
 1.38A 2nv4B-1lluA:
undetectable		 2nv4B-1lluA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2x CLASS B
CARBAPENEMASE BLAB-1

(Elizabethkingia
meningoseptica) 		PF00753
(Lactamase_B) 		5 ALA A  69
ASP A  90
LYS A  91
GLY A 124
LEU A 125
 None
 1.21A 2nv4B-1m2xA:
undetectable		 2nv4B-1m2xA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Neisseria
meningitidis) 		PF02548
(Pantoate_transf) 		5 GLN A 239
ALA A  34
GLY A  73
ASP A  32
LEU A  30
 None
 1.37A 2nv4B-1o66A:
0.0		 2nv4B-1o66A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ALA A 938
GLY A 931
ASP A 936
LEU A 926
SER A 923
 None
 1.23A 2nv4B-1ofeA:
0.0		 2nv4B-1ofeA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		5 ALA A1248
GLN A1256
ASP A1180
GLY A1261
LEU A1263
 None
 1.33A 2nv4B-1qhmA:
0.0		 2nv4B-1qhmA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 GLY A 720
LEU A 722
ASP A 766
LEU A 773
SER A 774
 None
 1.32A 2nv4B-1rrhA:
0.0		 2nv4B-1rrhA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7n THROMBOPOIETIN

(Homo sapiens) 		PF00758
(EPO_TPO) 		5 GLN V  61
ALA V  60
GLY V 102
LEU V  99
LEU V 108
 None
 1.35A 2nv4B-1v7nV:
0.0		 2nv4B-1v7nV:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yga HYPOTHETICAL 37.9
KDA PROTEIN IN
BIO3-HXT17
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		5 ALA A  23
GLY A  45
ASP A  34
LEU A  32
SER A 177
 None
 1.31A 2nv4B-1ygaA:
undetectable		 2nv4B-1ygaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389

(Mycobacterium
tuberculosis) 		PF13523
(Acetyltransf_8) 		5 TYR A 109
GLY A 128
LEU A 129
ASP A 168
LEU A 115
 None
 1.33A 2nv4B-1yk3A:
undetectable		 2nv4B-1yk3A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		5 ALA A 364
GLN A  59
GLY A  45
LEU A  46
SER A 356
 None
 1.29A 2nv4B-1yniA:
undetectable		 2nv4B-1yniA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzp PEROXIDASE
MANGANESE-DEPENDENT
I

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 ALA A 102
GLN A 107
GLY A  62
LEU A 279
LEU A  69
 None
None
CA  A 372 (-4.4A)
None
None
 1.38A 2nv4B-1yzpA:
undetectable		 2nv4B-1yzpA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		5 GLN A  60
ALA A  96
ASP A  97
LEU A  56
SER A 110
 None
None
FE  A1207 (-2.1A)
None
None
 1.34A 2nv4B-2c6rA:
undetectable		 2nv4B-2c6rA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 GLN A  11
ALA A   7
GLY A  91
LEU A  90
LEU A 149
 None
 1.05A 2nv4B-2cfmA:
undetectable		 2nv4B-2cfmA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		5 ALA A  15
GLN A  28
GLY A  90
LEU A  91
LEU A  11
 None
 1.37A 2nv4B-2e9yA:
undetectable		 2nv4B-2e9yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei9 NON-LTR
RETROTRANSPOSON
R1BMKS ORF2 PROTEIN

(Bombyx mori) 		PF14529
(Exo_endo_phos_2) 		5 ALA A  73
GLY A  62
LEU A  52
LEU A  75
SER A  79
 None
 1.25A 2nv4B-2ei9A:
undetectable		 2nv4B-2ei9A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fx5 LIPASE

(Pseudomonas
mendocina) 		no annotation 5 ALA A   9
TYR A  23
LYS A 114
PRO A  50
GLY A  76
 None
 1.32A 2nv4B-2fx5A:
undetectable		 2nv4B-2fx5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 GLY A 715
LEU A 717
ASP A 761
LEU A 768
SER A 769
 None
 1.35A 2nv4B-2iujA:
undetectable		 2nv4B-2iujA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ALA A 595
ASP A 712
GLY A 542
LEU A 543
SER A 183
 None
 1.23A 2nv4B-2ivfA:
undetectable		 2nv4B-2ivfA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE

(Mus musculus) 		PF02434
(Fringe) 		5 GLN A 271
ALA A 151
GLY A 200
LEU A 252
SER A 250
 None
 1.01A 2nv4B-2j0aA:
undetectable		 2nv4B-2j0aA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nv4 UPF0066 PROTEIN
AF_0241

(Archaeoglobus
fulgidus) 		PF01980
(UPF0066) 		11 GLN A  16
ALA A  19
GLN A  22
TYR A  55
ASP A  58
PRO A  84
GLY A  91
LEU A  92
ASP A 111
LEU A 113
SER A 116
 None
SAM  A 201 (-3.6A)
SAM  A 201 (-2.9A)
SAM  A 201 (-4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 ( 4.3A)
SAM  A 201 (-3.5A)
SAM  A 201 (-4.4A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.6A)
SAM  A 201 (-2.7A)
 0.41A 2nv4B-2nv4A:
25.9		 2nv4B-2nv4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nv4 UPF0066 PROTEIN
AF_0241

(Archaeoglobus
fulgidus) 		PF01980
(UPF0066) 		8 GLN A  16
GLN A  22
TYR A  55
ASP A  58
LYS A  59
PRO A  84
GLY A  91
LEU A  92
 None
SAM  A 201 (-2.9A)
SAM  A 201 (-4.8A)
SAM  A 201 (-3.5A)
None
SAM  A 201 ( 4.3A)
SAM  A 201 (-3.5A)
SAM  A 201 (-4.4A)
 0.69A 2nv4B-2nv4A:
25.9		 2nv4B-2nv4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nv4 UPF0066 PROTEIN
AF_0241

(Archaeoglobus
fulgidus) 		PF01980
(UPF0066) 		5 TYR A  55
PRO A  89
GLY A  91
LEU A  92
SER A 116
 SAM  A 201 (-4.8A)
None
SAM  A 201 (-3.5A)
SAM  A 201 (-4.4A)
SAM  A 201 (-2.7A)
 1.04A 2nv4B-2nv4A:
25.9		 2nv4B-2nv4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6y HYPOTHETICAL PROTEIN
VCA0587

(Vibrio cholerae) 		PF03479
(DUF296) 		5 GLN A 111
ALA A 131
PRO A 110
GLY A  31
LEU A  69
 None
 1.35A 2nv4B-2p6yA:
undetectable		 2nv4B-2p6yA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLN A 265
ALA A 268
ASP A 259
GLY A 292
LEU A 291
 None
 1.28A 2nv4B-2pp3A:
undetectable		 2nv4B-2pp3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvb HALOALKANE
DEHALOGENASE 3

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		5 GLN A  36
GLN A 121
TYR A  83
GLY A  84
ASP A 117
 None
 1.15A 2nv4B-2qvbA:
undetectable		 2nv4B-2qvbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 ALA A 452
ASP A 104
GLY A 219
LEU A 222
LEU A 213
 None
 1.35A 2nv4B-2qveA:
undetectable		 2nv4B-2qveA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		5 ALA A  81
TYR A 417
PRO A 421
GLY A 418
LEU A 116
 None
 1.00A 2nv4B-2rchA:
undetectable		 2nv4B-2rchA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5c HYPOTHETICAL PROTEIN
ORF131

(Pyrobaculum
spherical virus) 		no annotation 5 ALA A  36
GLN A  31
TYR A  72
ASP A  34
LEU A  75
 None
 1.02A 2nv4B-2x5cA:
undetectable		 2nv4B-2x5cA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		5 GLN A 152
ALA A 442
GLY A 422
LEU A 421
LEU A 392
 FAD  A 700 (-3.4A)
None
None
None
None
 1.38A 2nv4B-2ylzA:
undetectable		 2nv4B-2ylzA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 ALA A 293
TYR A  40
LEU A 314
LEU A 345
SER A 346
 None
 1.36A 2nv4B-2z8zA:
undetectable		 2nv4B-2z8zA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		5 GLN A 242
GLY A  41
LEU A  43
LEU A 221
SER A 155
 None
WO4  A 701 (-3.3A)
None
None
None
 1.36A 2nv4B-3cg1A:
undetectable		 2nv4B-3cg1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		5 GLN A 176
ALA A 177
GLY A 214
LEU A 216
LEU A 171
 None
 1.30A 2nv4B-3cq0A:
undetectable		 2nv4B-3cq0A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 ALA A 118
ASP A 206
GLY A 201
LEU A 198
LEU A 147
 None
 1.33A 2nv4B-3d1jA:
undetectable		 2nv4B-3d1jA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3a POSSIBLE PEROXIDASE
BPOC

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		5 ALA A 252
GLN A  32
GLY A 241
LEU A 240
LEU A 232
 None
None
None
MPD  A 265 (-3.7A)
None
 1.38A 2nv4B-3e3aA:
undetectable		 2nv4B-3e3aA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f75 CATHEPSIN L PROTEASE

(Toxoplasma
gondii) 		PF00112
(Peptidase_C1) 		5 ALA A  79
ASP A 120
GLY A 117
LEU A 116
SER A 220
 None
 1.09A 2nv4B-3f75A:
undetectable		 2nv4B-3f75A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fku NEUTRALIZING
ANTIBODY F10

(Homo sapiens) 		no annotation 5 ASP X 225
LYS X 245
PRO X 146
GLY X 241
LEU X 143
 None
 1.34A 2nv4B-3fkuX:
undetectable		 2nv4B-3fkuX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLN A 493
ALA A 359
GLN A 108
LEU A 131
LEU A 350
 None
 1.30A 2nv4B-3g25A:
undetectable		 2nv4B-3g25A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		5 ALA A  42
GLY A  65
LEU A  67
LEU A   6
SER A  22
 None
 1.37A 2nv4B-3h3eA:
undetectable		 2nv4B-3h3eA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxt 5-FORMYLTETRAHYDROFO
LATE CYCLO-LIGASE

(Homo sapiens) 		PF01812
(5-FTHF_cyc-lig) 		5 GLN A 182
PRO A 184
GLY A 138
LEU A 137
LEU A 181
 None
None
None
None
MG  A 214 (-4.6A)
 1.32A 2nv4B-3hxtA:
undetectable		 2nv4B-3hxtA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 ALA A 264
ASP A 189
PRO A 186
GLY A 161
LEU A 162
 None
 1.37A 2nv4B-3k6kA:
undetectable		 2nv4B-3k6kA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 ALA E  94
ASP E 198
PRO E 180
GLY E 183
LEU E 228
 None
 1.28A 2nv4B-3kfuE:
undetectable		 2nv4B-3kfuE:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 ALA A 244
PRO A 321
GLY A 299
LEU A 234
SER A 281
 None
 1.29A 2nv4B-3of7A:
undetectable		 2nv4B-3of7A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofl L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		5 GLN A 328
ALA A 162
ASP A 402
ASP A 244
SER A 398
 None
 1.25A 2nv4B-3oflA:
undetectable		 2nv4B-3oflA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pi7 NADH OXIDOREDUCTASE

(Mesorhizobium
loti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLN A  38
ALA A 329
LYS A  11
GLY A 117
LEU A 326
 None
None
None
GOL  A 349 (-3.3A)
None
 1.21A 2nv4B-3pi7A:
undetectable		 2nv4B-3pi7A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6z POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		5 ALA A 822
PRO A 883
GLY A 862
LEU A 860
SER A 904
 APR  A   1 (-3.3A)
None
None
None
None
 1.36A 2nv4B-3q6zA:
undetectable		 2nv4B-3q6zA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 ALA A 356
PRO A 149
GLY A 406
LEU A 401
SER A 417
 None
 1.22A 2nv4B-3qp9A:
undetectable		 2nv4B-3qp9A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r97 MALONYL COA-ACP
TRANSACYLASE

(Xanthomonas
oryzae) 		PF00698
(Acyl_transf_1) 		5 ALA A  38
GLN A  30
LEU A  24
LEU A  46
SER A  50
 None
 1.38A 2nv4B-3r97A:
undetectable		 2nv4B-3r97A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 ALA A 330
GLY A 369
LEU A 370
LEU A 336
SER A 340
 None
 1.32A 2nv4B-3s1sA:
undetectable		 2nv4B-3s1sA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnx PAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 GLN A 249
ALA A  71
ASP A 247
GLY A 253
LEU A 250
 None
 1.38A 2nv4B-3tnxA:
undetectable		 2nv4B-3tnxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 ALA A 169
GLN A 210
ASP A 155
GLY A 161
SER A 154
 None
None
None
SO4  A   4 (-3.2A)
None
 1.22A 2nv4B-3v5rA:
undetectable		 2nv4B-3v5rA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhb R-IMINE REDUCTASE

(Streptomyces
kanamyceticus) 		PF03446
(NAD_binding_2) 		6 ALA A 188
ASP A 179
GLY A 134
LEU A 109
ASP A 187
LEU A 185
 None
 1.25A 2nv4B-3zhbA:
undetectable		 2nv4B-3zhbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,
NUCLEAR RECEPTOR
COREPRESSOR 2

(Homo sapiens;
Homo sapiens) 		PF00850
(Hist_deacetyl)
PF00249
(Myb_DNA-binding) 		5 GLN A  52
GLN A 117
PRO A  50
GLY C 414
LEU C 415
 None
 1.33A 2nv4B-4a69A:
undetectable		 2nv4B-4a69A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4d FERREDOXIN-NADP
REDUCTASE

(Xanthomonas
citri) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 PRO A  96
GLY A  36
LEU A 100
LEU A  65
SER A  58
 None
 1.26A 2nv4B-4b4dA:
3.7		 2nv4B-4b4dA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8a POLY(A) RIBONUCLEASE
POP2

(Saccharomyces
cerevisiae) 		PF04857
(CAF1) 		5 GLN B 260
PRO B   9
GLY B  90
LEU B 252
SER B  84
 None
 1.35A 2nv4B-4b8aB:
undetectable		 2nv4B-4b8aB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1x NADPH:FERREDOXIN
REDUCTASE

(Rhodobacter
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 PRO A 108
GLY A  47
LEU A 112
LEU A  77
SER A  70
 None
 1.34A 2nv4B-4k1xA:
3.8		 2nv4B-4k1xA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF)
PF01012
(ETF) 		5 ALA B 143
GLN B 140
ASP A 130
GLY A 116
ASP A 114
 None
 1.10A 2nv4B-4kpuB:
undetectable		 2nv4B-4kpuB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		5 ALA A 119
ASP A  87
PRO A 188
LEU A 185
ASP A 118
 None
MG  A 501 ( 4.1A)
None
None
None
 1.24A 2nv4B-4lsbA:
undetectable		 2nv4B-4lsbA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 284
PRO A 312
GLY A 126
LEU A 125
ASP A 280
 None
 1.15A 2nv4B-4mggA:
undetectable		 2nv4B-4mggA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		5 ALA A 146
GLN A  47
GLY A 259
LEU A 258
LEU A 124
 None
 1.11A 2nv4B-4n6dA:
undetectable		 2nv4B-4n6dA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		5 ALA A 173
GLY A 201
LEU A 200
ASP A 172
SER A 160
 None
 1.18A 2nv4B-4o5aA:
undetectable		 2nv4B-4o5aA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59

(Homo sapiens) 		no annotation 5 ASP L  85
LYS L 103
PRO L   7
GLY L  99
LEU L   4
 None
 1.39A 2nv4B-4qf1L:
undetectable		 2nv4B-4qf1L:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A 333
GLY A 216
LEU A 230
ASP A 330
LEU A 343
 None
 1.33A 2nv4B-4qhrA:
2.3		 2nv4B-4qhrA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ALA A 183
GLN A 157
ASP A 185
LEU A 194
SER A 192
 None
 1.05A 2nv4B-4r6lA:
undetectable		 2nv4B-4r6lA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN

(Homo sapiens;
Homo sapiens) 		PF06535
(RGM_N)
PF06534
(RGM_C)
PF06535
(RGM_N) 		5 ALA D 300
ASP D 176
GLY C 164
LEU C 165
LEU C 161
 None
 1.36A 2nv4B-4ui2D:
undetectable		 2nv4B-4ui2D:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		5 ALA Q 472
ASP Q 114
PRO Q 498
GLY Q 384
ASP Q 473
 None
CSX  Q  75 ( 4.5A)
FCO  Q1550 (-3.5A)
None
None
 1.35A 2nv4B-4upeQ:
undetectable		 2nv4B-4upeQ:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE
ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
no annotation 		5 GLN D 360
ALA D 315
GLY A 346
LEU A 345
LEU D 354
 None
 0.92A 2nv4B-4x28D:
undetectable		 2nv4B-4x28D:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		5 GLN A 131
ALA A 162
ASP A 177
GLY A 183
LEU A 186
 GSH  A 401 (-3.1A)
None
GSH  A 401 (-3.0A)
None
None
 1.26A 2nv4B-4z9nA:
undetectable		 2nv4B-4z9nA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus;
Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF01399
(PCI)
PF01398
(JAB)
PF13012
(MitMem_reg)
PF01398
(JAB)
PF01399
(PCI) 		5 ALA H 344
GLN A 522
LEU F 285
LEU M 369
SER M 370
 None
 1.37A 2nv4B-5a5tH:
undetectable		 2nv4B-5a5tH:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		5 ALA A 107
GLN A 298
GLY A 332
LEU A 331
LEU A 335
 None
 1.35A 2nv4B-5abmA:
undetectable		 2nv4B-5abmA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ado FAB A.17

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASP L  86
LYS L 105
PRO L   7
GLY L 101
LEU L   4
 None
 1.32A 2nv4B-5adoL:
undetectable		 2nv4B-5adoL:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ALA A 392
GLY A 186
LEU A 185
LEU A 410
SER A 409
 None
 1.21A 2nv4B-5c2cA:
undetectable		 2nv4B-5c2cA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6w PROTEIN
IGHV1-69-2,IG LAMBDA
CHAIN V-II REGION
NIG-84

(Homo sapiens) 		PF07686
(V-set) 		5 ASP H1087
LYS H1106
PRO H1007
GLY H1102
LEU H1004
 None
None
PEG  H1224 ( 4.1A)
None
None
 1.35A 2nv4B-5c6wH:
undetectable		 2nv4B-5c6wH:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 ALA A 144
PRO A  97
GLY A  40
LEU A  41
ASP A 121
 None
None
None
None
T6T  A 401 (-2.0A)
 1.36A 2nv4B-5dkvA:
undetectable		 2nv4B-5dkvA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		5 ALA A 278
PRO A 254
GLY A  21
ASP A 302
LEU A 306
 None
 1.34A 2nv4B-5dmnA:
undetectable		 2nv4B-5dmnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 ALA A 428
PRO A 271
GLY A 480
LEU A 469
SER A 472
 ADP  A 901 ( 3.7A)
PG4  A 903 (-3.8A)
None
None
None
 1.38A 2nv4B-5e7pA:
undetectable		 2nv4B-5e7pA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9c HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 ASP A 357
GLY A 362
LEU A 366
LEU A 355
SER A 356
 None
 1.24A 2nv4B-5e9cA:
undetectable		 2nv4B-5e9cA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ew5 COLICIN-E9

(Escherichia
coli) 		PF03515
(Cloacin) 		5 ALA A 474
PRO A 483
GLY A 467
ASP A 473
LEU A 471
 None
 1.12A 2nv4B-5ew5A:
undetectable		 2nv4B-5ew5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 GLN A1064
ALA A1010
GLY A 807
LEU A 791
ASP A1009
 None
 1.25A 2nv4B-5f7uA:
undetectable		 2nv4B-5f7uA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 TYR A 238
GLY A 248
LEU A 455
ASP A 154
LEU A 113
 None
 1.25A 2nv4B-5gxdA:
undetectable		 2nv4B-5gxdA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		5 GLN A  86
PRO A 137
GLY A  92
LEU A  93
SER A 106
 None
 1.17A 2nv4B-5jmdA:
undetectable		 2nv4B-5jmdA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz7 MEDI578 SCFV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 ASP D  85
LYS D 103
PRO D   7
GLY D  99
LEU D   4
 None
 1.29A 2nv4B-5jz7D:
undetectable		 2nv4B-5jz7D:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 PRO A 481
GLY A 449
LEU A 455
ASP A 430
SER A 353
 None
 1.23A 2nv4B-5l5gA:
undetectable		 2nv4B-5l5gA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 ASP A 357
GLY A 362
LEU A 366
LEU A 355
SER A 356
 None
 1.22A 2nv4B-5la7A:
undetectable		 2nv4B-5la7A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 5 GLN A  72
ALA A  68
TYR A  44
GLY A  12
LEU A  11
 None
 1.36A 2nv4B-5lw3A:
undetectable		 2nv4B-5lw3A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mes LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASP L  86
LYS L 106
PRO L   7
GLY L 102
LEU L   4
 None
 1.36A 2nv4B-5mesL:
undetectable		 2nv4B-5mesL:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 5 ALA A  65
ASP A 358
GLY A 249
LEU A 270
ASP A  78
 None
CIT  A 502 (-3.6A)
None
None
None
 1.26A 2nv4B-5nijA:
undetectable		 2nv4B-5nijA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 5 GLN A 336
ALA A 332
LEU A 272
LEU A 319
SER A 317
 None
 1.18A 2nv4B-5ukhA:
undetectable		 2nv4B-5ukhA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D

(Methylobacterium
extorquens) 		no annotation 5 ALA A  56
GLN A 252
PRO A 247
GLY A 244
LEU A 236
 None
 1.30A 2nv4B-5vrcA:
undetectable		 2nv4B-5vrcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 GLN A 989
ALA A1114
PRO A 987
LEU A1123
SER A1125
 None
 1.11A 2nv4B-5x7sA:
undetectable		 2nv4B-5x7sA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus) 		no annotation 5 ALA A  40
GLN A  82
PRO A 163
GLY A 150
LEU A 159
 None
 1.35A 2nv4B-5xrfA:
undetectable		 2nv4B-5xrfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2n -

(-) 		no annotation 5 ALA B  55
ASP B  38
GLY B  48
LEU B  47
LEU B  52
 None
 1.35A 2nv4B-5z2nB:
undetectable		 2nv4B-5z2nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze8 CYTOCHROME C552

(Thermochromatium
tepidum) 		no annotation 5 ALA A 107
GLN A 111
PRO A  97
GLY A  87
LEU A 115
 None
 1.32A 2nv4B-5ze8A:
undetectable		 2nv4B-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2
PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C;
Aquareovirus C) 		no annotation
no annotation 		5 GLN 2 655
TYR 2 601
ASP 4 524
LEU 2 657
SER 4 574
 None
 1.37A 2nv4B-5zvs2:
undetectable		 2nv4B-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ALA A 297
GLN A 181
PRO A 307
GLY A 485
LEU A 316
 None
 1.31A 2nv4B-6aqhA:
undetectable		 2nv4B-6aqhA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 5 ALA A  76
GLN A 287
PRO A 283
LEU A 331
LEU A 341
 None
None
RFH  A 502 ( 4.2A)
None
RFH  A 502 (-4.4A)
 1.38A 2nv4B-6c7sA:
undetectable		 2nv4B-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9g METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
MCPU

(Pseudomonas
putida) 		no annotation 5 GLN A 191
TYR A 120
PRO A 219
GLY A 231
LEU A 187
 None
PUT  A 401 (-4.2A)
None
None
None
 1.35A 2nv4B-6f9gA:
undetectable		 2nv4B-6f9gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 5 ALA A 345
ASP A 105
ASP A 346
LEU A 339
SER A 369
 None
 1.35A 2nv4B-6gnfA:
undetectable		 2nv4B-6gnfA:
undetectable