SIMILAR PATTERNS OF AMINO ACIDS FOR 2NV4_A_ACTA148_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ako EXONUCLEASE III

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		3 VAL A  22
GLU A  19
GLU A  23
 None
 0.79A 2nv4A-1akoA:
0.0		 2nv4A-1akoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)

(Escherichia
coli) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 VAL A   6
GLU A 242
GLU A 241
 None
 0.80A 2nv4A-1b3nA:
0.0		 2nv4A-1b3nA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjx PROTEIN DISULFIDE
ISOMERASE

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		3 VAL A 133
GLU A 130
GLU A 134
 None
 0.68A 2nv4A-1bjxA:
0.0		 2nv4A-1bjxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		3 VAL A 120
GLU A 116
GLU A 115
 None
 0.80A 2nv4A-1e1kA:
0.0		 2nv4A-1e1kA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE

(Escherichia
coli) 		PF01634
(HisG)
PF08029
(HisG_C) 		3 VAL A  76
GLU A  80
GLU A  79
 None
 0.78A 2nv4A-1h3dA:
undetectable		 2nv4A-1h3dA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzc COLD SHOCK PROTEIN
CSPB

([Bacillus]
caldolyticus) 		PF00313
(CSD) 		3 VAL A   6
GLU A  42
GLU A  43
 None
 0.62A 2nv4A-1hzcA:
1.2		 2nv4A-1hzcA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE

(Pyrococcus
horikoshii) 		PF00857
(Isochorismatase) 		3 VAL A 120
GLU A   4
GLU A   3
 None
 0.68A 2nv4A-1im5A:
undetectable		 2nv4A-1im5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		3 VAL A 177
GLU A 181
GLU A 180
 None
 0.72A 2nv4A-1mozA:
undetectable		 2nv4A-1mozA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npr TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Aquifex
aeolicus) 		PF00467
(KOW)
PF02357
(NusG)
PF07009
(NusG_II) 		3 VAL A  99
GLU A 121
GLU A 100
 None
 0.80A 2nv4A-1nprA:
undetectable		 2nv4A-1nprA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE

(Thermotoga
maritima) 		PF04961
(FTCD_C) 		3 VAL A  55
GLU A  53
GLU A  56
 None
 0.78A 2nv4A-1o5hA:
undetectable		 2nv4A-1o5hA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		3 VAL A  88
GLU A  85
GLU A  89
 None
 0.70A 2nv4A-1r5jA:
undetectable		 2nv4A-1r5jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 VAL A 580
GLU A 588
GLU A 589
 None
 0.79A 2nv4A-1r5nA:
2.3		 2nv4A-1r5nA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		3 VAL B 112
GLU B  52
GLU B 111
 None
 0.76A 2nv4A-1ta3B:
undetectable		 2nv4A-1ta3B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujo TRANSGELIN

(Mus musculus) 		PF00307
(CH) 		3 VAL A  15
GLU A  12
GLU A  16
 None
 0.62A 2nv4A-1ujoA:
undetectable		 2nv4A-1ujoA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v63 NUCLEOLAR
TRANSCRIPTION FACTOR
1

(Mus musculus) 		PF09011
(HMG_box_2) 		3 VAL A  39
GLU A  36
GLU A  40
 None
 0.59A 2nv4A-1v63A:
undetectable		 2nv4A-1v63A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		3 VAL A 150
GLU A 146
GLU A 147
 None
 0.81A 2nv4A-1vf8A:
undetectable		 2nv4A-1vf8A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		3 VAL A 214
GLU A 211
GLU A 215
 None
 0.79A 2nv4A-1vhkA:
undetectable		 2nv4A-1vhkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x67 DREBRIN-LIKE PROTEIN

(Homo sapiens) 		PF00241
(Cofilin_ADF) 		3 VAL A  61
GLU A  58
GLU A  62
 None
 0.81A 2nv4A-1x67A:
undetectable		 2nv4A-1x67A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 VAL A 310
GLU A 271
GLU A 313
 None
 0.63A 2nv4A-1x8vA:
undetectable		 2nv4A-1x8vA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		3 VAL A  99
GLU A  96
GLU A 100
 None
 0.74A 2nv4A-2b3tA:
undetectable		 2nv4A-2b3tA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 VAL A 152
GLU A 149
GLU A 167
 None
 0.78A 2nv4A-2d3iA:
undetectable		 2nv4A-2d3iA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7l WD REPEAT AND
HMG-BOX DNA BINDING
PROTEIN 1

(Homo sapiens) 		PF00505
(HMG_box) 		3 VAL A  55
GLU A  51
GLU A  52
 None
 0.76A 2nv4A-2d7lA:
undetectable		 2nv4A-2d7lA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		3 VAL A 380
GLU A 335
GLU A 381
 None
 0.65A 2nv4A-2dsjA:
undetectable		 2nv4A-2dsjA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
agalactiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 VAL A 238
GLU A 234
GLU A 235
 None
 0.75A 2nv4A-2enxA:
undetectable		 2nv4A-2enxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		3 VAL A 190
GLU A 194
GLU A 193
 None
 0.80A 2nv4A-2eq5A:
undetectable		 2nv4A-2eq5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2keb DNA POLYMERASE
SUBUNIT ALPHA B

(Homo sapiens) 		no annotation 3 VAL A  28
GLU A  25
GLU A  29
 None
 0.77A 2nv4A-2kebA:
undetectable		 2nv4A-2kebA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0t SIGNAL TRANSDUCING
ADAPTER MOLECULE 2

(Homo sapiens) 		PF00790
(VHS) 		3 VAL B  20
GLU B  17
GLU B  21
 None
 0.72A 2nv4A-2l0tB:
undetectable		 2nv4A-2l0tB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkk FATTY ACID-BINDING
PROTEIN, LIVER

(Homo sapiens) 		PF14651
(Lipocalin_7) 		3 VAL A  82
GLU A  67
GLU A  68
 None
 0.65A 2nv4A-2lkkA:
undetectable		 2nv4A-2lkkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m45 MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		no annotation 3 VAL A 645
GLU A 677
GLU A 681
 None
 0.76A 2nv4A-2m45A:
undetectable		 2nv4A-2m45A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		3 VAL A 300
GLU A 366
GLU A 296
 None
 0.75A 2nv4A-2mbgA:
undetectable		 2nv4A-2mbgA:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nv4 UPF0066 PROTEIN
AF_0241

(Archaeoglobus
fulgidus) 		PF01980
(UPF0066) 		3 VAL A  68
GLU A  74
GLU A  75
 None
ACT  A 148 (-3.6A)
None
 0.02A 2nv4A-2nv4A:
27.8		 2nv4A-2nv4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		3 VAL A  48
GLU A  61
GLU A  45
 None
 0.69A 2nv4A-2nxoA:
undetectable		 2nv4A-2nxoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8x PROBABLE RNA
POLYMERASE SIGMA-C
FACTOR

(Mycobacterium
tuberculosis) 		PF08281
(Sigma70_r4_2) 		3 VAL A 122
GLU A 119
GLU A 123
 None
 0.77A 2nv4A-2o8xA:
undetectable		 2nv4A-2o8xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptm HYPERPOLARIZATION-AC
TIVATED (IH) CHANNEL

(Strongylocentrotus
purpuratus) 		PF00027
(cNMP_binding) 		3 VAL A 659
GLU A 655
GLU A 656
 None
 0.80A 2nv4A-2ptmA:
undetectable		 2nv4A-2ptmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm3 PREDICTED
METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01861
(DUF43) 		3 VAL A  21
GLU A  18
GLU A  22
 None
 0.81A 2nv4A-2qm3A:
undetectable		 2nv4A-2qm3A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		3 VAL A  57
GLU A 312
GLU A  20
 None
 0.69A 2nv4A-2qp2A:
undetectable		 2nv4A-2qp2A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 VAL A 308
GLU A 305
GLU A 309
 None
 0.77A 2nv4A-2qquA:
undetectable		 2nv4A-2qquA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		3 VAL A  95
GLU A 269
GLU A 266
 None
 0.60A 2nv4A-2w8qA:
undetectable		 2nv4A-2w8qA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		3 VAL A 502
GLU A 504
GLU A 503
 EDO  A 540 ( 4.6A)
EDO  A 540 (-3.7A)
None
 0.77A 2nv4A-2yeqA:
undetectable		 2nv4A-2yeqA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn2 UNCHARACTERIZED
PROTEIN YNL108C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		3 VAL A  41
GLU A  38
GLU A  42
 None
 0.76A 2nv4A-2yn2A:
undetectable		 2nv4A-2yn2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr1 3-DEHYDROQUINATE
DEHYDRATASE

(Geobacillus
kaustophilus) 		PF01487
(DHquinase_I) 		3 VAL A  41
GLU A  37
GLU A  40
 None
 0.80A 2nv4A-2yr1A:
undetectable		 2nv4A-2yr1A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 3 VAL A 343
GLU A 138
GLU A 345
 None
 0.73A 2nv4A-2yr5A:
undetectable		 2nv4A-2yr5A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Aeropyrum
pernix) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 VAL A 137
GLU A 134
GLU A 138
 None
 0.73A 2nv4A-3agkA:
undetectable		 2nv4A-3agkA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay5 CYCLIN-D1-BINDING
PROTEIN 1

(Homo sapiens) 		PF13324
(GCIP) 		3 VAL A 195
GLU A 192
GLU A 196
 None
 0.79A 2nv4A-3ay5A:
undetectable		 2nv4A-3ay5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b09 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Shewanella sp.
SIB1) 		PF01346
(FKBP_N) 		3 VAL A  59
GLU A  55
GLU A  56
 None
 0.81A 2nv4A-3b09A:
undetectable		 2nv4A-3b09A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		3 VAL A 165
GLU A 194
GLU A 162
 None
 0.68A 2nv4A-3cs3A:
undetectable		 2nv4A-3cs3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 VAL A 318
GLU A 136
GLU A 316
 None
 0.70A 2nv4A-3dbgA:
undetectable		 2nv4A-3dbgA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		3 VAL A 100
GLU A  97
GLU A 101
 None
 0.68A 2nv4A-3dwcA:
undetectable		 2nv4A-3dwcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF03143
(GTP_EFTU_D3) 		3 VAL A 580
GLU A 588
GLU A 589
 None
 0.81A 2nv4A-3e20A:
2.6		 2nv4A-3e20A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		3 VAL A 137
GLU A 134
GLU A 138
 None
 0.78A 2nv4A-3ezxA:
undetectable		 2nv4A-3ezxA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g33 CCND3 PROTEIN

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		3 VAL B  39
GLU B  35
GLU B  36
 None
 0.81A 2nv4A-3g33B:
undetectable		 2nv4A-3g33B:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		3 VAL A 280
GLU A 277
GLU A 281
 None
 0.79A 2nv4A-3gs6A:
undetectable		 2nv4A-3gs6A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT

(Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 VAL C 238
GLU C 234
GLU C 235
 None
 0.78A 2nv4A-3hrdC:
undetectable		 2nv4A-3hrdC:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqt SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE BARA

(Escherichia
coli) 		PF01627
(Hpt) 		3 VAL A 849
GLU A 845
GLU A 846
 None
 0.73A 2nv4A-3iqtA:
undetectable		 2nv4A-3iqtA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		3 VAL P 388
GLU P 437
GLU P 435
 None
 0.74A 2nv4A-3izyP:
2.2		 2nv4A-3izyP:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		3 VAL A 104
GLU A 100
GLU A 101
 None
 0.68A 2nv4A-3jxzA:
undetectable		 2nv4A-3jxzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljn HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF00023
(Ank)
PF12796
(Ank_2) 		3 VAL A 227
GLU A 258
GLU A 228
 None
 0.79A 2nv4A-3ljnA:
undetectable		 2nv4A-3ljnA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
ALPHA

(Bos taurus) 		PF06957
(COPI_C) 		3 VAL B1026
GLU B1023
GLU B1027
 None
 0.71A 2nv4A-3mkrB:
undetectable		 2nv4A-3mkrB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		3 VAL A 348
GLU A 344
GLU A 345
 None
 0.76A 2nv4A-3ne5A:
undetectable		 2nv4A-3ne5A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		3 VAL A 337
GLU A 333
GLU A 334
 None
 0.79A 2nv4A-3nfbA:
undetectable		 2nv4A-3nfbA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		3 VAL A 135
GLU A 132
GLU A 136
 None
 0.78A 2nv4A-3oyrA:
undetectable		 2nv4A-3oyrA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pam TRANSMEMBRANE
PROTEIN

(Bartonella
henselae) 		PF00496
(SBP_bac_5) 		3 VAL A 458
GLU A 454
GLU A 455
 None
 0.80A 2nv4A-3pamA:
undetectable		 2nv4A-3pamA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		3 VAL A  92
GLU A  88
GLU A  89
 None
 0.78A 2nv4A-3qvmA:
undetectable		 2nv4A-3qvmA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(uncultured
archaeon) 		PF02240
(MCR_gamma) 		3 VAL C  37
GLU C  33
GLU C  34
 None
 0.79A 2nv4A-3sqgC:
undetectable		 2nv4A-3sqgC:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN) 		3 VAL A 342
GLU A 338
GLU A 339
 None
 0.73A 2nv4A-3tw8A:
undetectable		 2nv4A-3tw8A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf1 VIMENTIN

(Homo sapiens) 		PF00038
(Filament) 		3 VAL A 224
GLU A 221
GLU A 225
 None
 0.81A 2nv4A-3uf1A:
undetectable		 2nv4A-3uf1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		3 VAL A 130
GLU A 127
GLU A 131
 None
 0.81A 2nv4A-3vnkA:
undetectable		 2nv4A-3vnkA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		3 VAL A   2
GLU A  22
GLU A   3
 None
 0.80A 2nv4A-4df3A:
undetectable		 2nv4A-4df3A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dup QUINONE
OXIDOREDUCTASE

(Rhizobium etli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  38
GLU A  41
GLU A  74
 None
 0.69A 2nv4A-4dupA:
undetectable		 2nv4A-4dupA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		3 VAL A 239
GLU A 330
GLU A 357
 DMS  A 504 ( 4.7A)
None
DMS  A 504 ( 3.6A)
 0.80A 2nv4A-4g09A:
undetectable		 2nv4A-4g09A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmq PUTATIVE RIBOSOME
ASSOCIATED PROTEIN

(Chaetomium
thermophilum) 		PF16717
(RAC_head) 		3 VAL A 422
GLU A 426
GLU A 425
 None
 0.71A 2nv4A-4gmqA:
undetectable		 2nv4A-4gmqA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		3 VAL A 347
GLU A 353
GLU A 352
 None
 0.59A 2nv4A-4hb9A:
undetectable		 2nv4A-4hb9A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13365
(Trypsin_2) 		3 VAL A  92
GLU A  88
GLU A  89
 None
None
CA  A 401 ( 3.6A)
 0.78A 2nv4A-4ic5A:
undetectable		 2nv4A-4ic5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		3 VAL A 126
GLU A 418
GLU A 123
 None
 0.71A 2nv4A-4ipeA:
undetectable		 2nv4A-4ipeA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 3 VAL D 242
GLU D 239
GLU D 243
 None
 0.73A 2nv4A-4j5xD:
undetectable		 2nv4A-4j5xD:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jel CMP/HYDROXYMETHYL
CMP HYDROLASE

(Streptomyces
rimofaciens) 		PF05014
(Nuc_deoxyrib_tr) 		3 VAL A 137
GLU A 132
GLU A 138
 None
 0.69A 2nv4A-4jelA:
undetectable		 2nv4A-4jelA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jem CMP/HYDROXYMETHYL
CMP HYDROLASE

(Streptomyces
rimofaciens) 		PF05014
(Nuc_deoxyrib_tr) 		3 VAL A 137
GLU A 132
GLU A 138
 None
 0.79A 2nv4A-4jemA:
undetectable		 2nv4A-4jemA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr4 HYPOTHETICAL PROTEIN

([Eubacterium]
rectale) 		no annotation 3 VAL A 387
GLU A  55
GLU A 293
 None
 0.78A 2nv4A-4lr4A:
undetectable		 2nv4A-4lr4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 VAL A 734
GLU A 730
GLU A 731
 None
 0.80A 2nv4A-4m0mA:
undetectable		 2nv4A-4m0mA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		3 VAL A 157
GLU A 127
GLU A 160
 None
 0.75A 2nv4A-4m88A:
undetectable		 2nv4A-4m88A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		3 VAL A 117
GLU A 119
GLU A 166
 None
 0.67A 2nv4A-4muoA:
undetectable		 2nv4A-4muoA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		PF09084
(NMT1) 		3 VAL A 122
GLU A  64
GLU A 119
 None
VIB  A 401 (-2.9A)
None
 0.80A 2nv4A-4nmyA:
undetectable		 2nv4A-4nmyA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Thermus
thermophilus) 		PF00254
(FKBP_C) 		3 VAL A 132
GLU A  48
GLU A  49
 None
 0.81A 2nv4A-4odmA:
undetectable		 2nv4A-4odmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Thermus
thermophilus;
Homo sapiens) 		PF00254
(FKBP_C) 		3 VAL A  84
GLU A  48
GLU A  49
 None
 0.81A 2nv4A-4odrA:
undetectable		 2nv4A-4odrA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oun MINI-RIBONUCLEASE 3

(Bacillus
subtilis) 		PF00636
(Ribonuclease_3) 		3 VAL A  98
GLU A  94
GLU A  95
 None
 0.80A 2nv4A-4ounA:
undetectable		 2nv4A-4ounA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 VAL A 196
GLU A 198
GLU A 199
 None
 0.77A 2nv4A-4upiA:
undetectable		 2nv4A-4upiA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		3 VAL A 301
GLU A 298
GLU A 302
 None
 0.81A 2nv4A-4uxvA:
undetectable		 2nv4A-4uxvA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wql 2''-AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE

(Klebsiella
pneumoniae) 		PF10706
(Aminoglyc_resit) 		3 VAL A  61
GLU A  58
GLU A  62
 None
 0.77A 2nv4A-4wqlA:
undetectable		 2nv4A-4wqlA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu8 DNA STABILIZATION
PROTEIN

(Salmonella
virus HK620) 		no annotation 3 VAL A  68
GLU A  65
GLU A  69
 None
 0.80A 2nv4A-5bu8A:
undetectable		 2nv4A-5bu8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d73 GLUTATHIONE
S-TRANSFERASE

(Wuchereria
bancrofti) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 VAL A 153
GLU A 157
GLU A 156
 None
 0.65A 2nv4A-5d73A:
undetectable		 2nv4A-5d73A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM

(Oryctolagus
cuniculus) 		PF13405
(EF-hand_6) 		3 VAL C 131
GLU C 128
GLU C 132
 None
 0.75A 2nv4A-5h53C:
undetectable		 2nv4A-5h53C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hde TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 12

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 VAL A 202
GLU A 284
GLU A 281
 None
 0.74A 2nv4A-5hdeA:
undetectable		 2nv4A-5hdeA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 VAL A1010
GLU A 951
GLU A1011
 None
 0.72A 2nv4A-5iy9A:
undetectable		 2nv4A-5iy9A:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1

(Homo sapiens) 		PF07565
(Band_3_cyto) 		3 VAL A  59
GLU A  56
GLU A  57
 None
 0.77A 2nv4A-5jhoA:
undetectable		 2nv4A-5jhoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l20 CLOSTRIPAIN-RELATED
PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 3 VAL A  66
GLU A  63
GLU A  67
 None
 0.70A 2nv4A-5l20A:
undetectable		 2nv4A-5l20A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		3 VAL A 612
GLU A 608
GLU A 609
 None
 0.80A 2nv4A-5l46A:
undetectable		 2nv4A-5l46A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1) 		3 VAL D 257
GLU D 438
GLU D 437
 None
 0.75A 2nv4A-5mg3D:
undetectable		 2nv4A-5mg3D:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v88 LYSOZYME,DCN1-LIKE
PROTEIN 1

(Homo sapiens;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF03556
(Cullin_binding) 		3 VAL A1244
GLU A1232
GLU A1245
 None
 0.77A 2nv4A-5v88A:
undetectable		 2nv4A-5v88A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrk AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 3 VAL A 406
GLU A 408
GLU A 211
 None
 0.79A 2nv4A-5wrkA:
undetectable		 2nv4A-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0n ENVELOPE
GLYCOPROTEIN GP140

(Human
immunodeficiency
virus 1) 		no annotation 3 VAL G 506
GLU G 657
GLU G 654
 None
 0.80A 2nv4A-6b0nG:
undetectable		 2nv4A-6b0nG:
undetectable