SIMILAR PATTERNS OF AMINO ACIDS FOR 2NPN_A_SAMA4633
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cp9 | PENICILLIN G AMIDASE (Providenciarettgeri) |
PF01804(Penicil_amidase) | 5 | GLY B 360LEU B 355THR B 358ALA B 357THR B 426 | None | 1.09A | 2npnA-1cp9B:undetectable | 2npnA-1cp9B:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e1k | ADRENODOXINREDUCTASE (Bos taurus) |
PF07992(Pyr_redox_2) | 5 | THR A 21GLY A 18TYR A 37LEU A 91LEU A 390 | None | 1.24A | 2npnA-1e1kA:undetectable | 2npnA-1e1kA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g71 | DNA PRIMASE (Pyrococcusfuriosus) |
PF01896(DNA_primase_S) | 5 | THR A 284GLY A 281TYR A 278LEU A 124THR A 128 | None | 1.27A | 2npnA-1g71A:undetectable | 2npnA-1g71A:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8p | MAGNESIUM-CHELATASE38 KDA SUBUNIT (Rhodobactercapsulatus) |
PF01078(Mg_chelatase) | 5 | THR A 293GLY A 210ALA A 322LEU A 34LEU A 294 | None | 1.27A | 2npnA-1g8pA:undetectable | 2npnA-1g8pA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i1q | ANTHRANILATESYNTHASE COMPONENT I (Salmonellaenterica) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | THR A 464GLY A 454TYR A 173LEU A 154LEU A 312 | NoneTRP A1001 ( 3.8A)NoneNoneNone | 1.06A | 2npnA-1i1qA:undetectable | 2npnA-1i1qA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3n | 3-OXOACYL-(ACYL-CARRIER PROTEIN)SYNTHASE II (Thermusthermophilus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 341LEU A 339ALA A 345LEU A 12LEU A 168 | None | 1.20A | 2npnA-1j3nA:undetectable | 2npnA-1j3nA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 5 | THR A 733GLY A 818ALA A 815LEU A 810LEU A 735 | None | 0.98A | 2npnA-1l5jA:undetectable | 2npnA-1l5jA:15.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r5n | EUKARYOTIC PEPTIDECHAIN RELEASE FACTORGTP-BINDING SUBUNIT (Schizosaccharomycespombe) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3) | 5 | THR A 585GLY A 544THR A 543ALA A 474LEU A 532 | None | 1.27A | 2npnA-1r5nA:2.5 | 2npnA-1r5nA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rr9 | ATP-DEPENDENTPROTEASE LA (Escherichiacoli) |
PF05362(Lon_C) | 5 | GLY A 681TYR A 626ALA A 640LEU A 624LEU A 709 | None | 1.08A | 2npnA-1rr9A:undetectable | 2npnA-1rr9A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1taq | TAQ DNA POLYMERASE (Thermusaquaticus) |
PF00476(DNA_pol_A)PF01367(5_3_exonuc)PF02739(5_3_exonuc_N)PF09281(Taq-exonuc) | 5 | GLY A 198THR A 203ALA A 204LEU A 208THR A 186 | None | 1.24A | 2npnA-1taqA:undetectable | 2npnA-1taqA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wrm | DUAL SPECIFICITYPHOSPHATASE 22 (Homo sapiens) |
PF00782(DSPc) | 5 | THR A 107LEU A 150TYR A 154THR A 105LEU A 79 | None | 0.96A | 2npnA-1wrmA:2.9 | 2npnA-1wrmA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xoc | OLIGOPEPTIDE-BINDINGPROTEIN APPA (Bacillussubtilis) |
PF00496(SBP_bac_5) | 5 | LEU A 38TYR A 39THR A 156ALA A 157LEU A 34 | None | 1.24A | 2npnA-1xocA:undetectable | 2npnA-1xocA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yln | HYPOTHETICAL PROTEINVCA0042 (Vibrio cholerae) |
PF07238(PilZ)PF12945(YcgR_2) | 5 | GLY A 204THR A 203ALA A 186LEU A 160LEU A 150 | None | 1.29A | 2npnA-1ylnA:undetectable | 2npnA-1ylnA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eta | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 2 (Rattusnorvegicus) |
PF12796(Ank_2) | 5 | GLY A 278LEU A 275TYR A 271LEU A 253THR A 248 | None | 1.05A | 2npnA-2etaA:undetectable | 2npnA-2etaA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f37 | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 2 (Homo sapiens) |
PF12796(Ank_2) | 5 | GLY A 277LEU A 274TYR A 270LEU A 252THR A 247 | None | 1.08A | 2npnA-2f37A:undetectable | 2npnA-2f37A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fj0 | CARBOXYLIC ESTERHYDROLASE (Manduca sexta) |
PF00135(COesterase) | 5 | GLY A 224LEU A 222THR A 232ALA A 231LEU A 202 | None | 1.15A | 2npnA-2fj0A:2.6 | 2npnA-2fj0A:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gah | HETEROTETRAMERICSARCOSINE OXIDASEGAMMA-SUBUNIT (Stenotrophomonasmaltophilia) |
PF04268(SoxG) | 5 | GLY C 128THR C 127ALA C 172LEU C 165THR C 168 | None | 1.18A | 2npnA-2gahC:undetectable | 2npnA-2gahC:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i1y | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | THR A 884LEU A 963ALA A 965LEU A 921LEU A 888 | None | 1.30A | 2npnA-2i1yA:3.5 | 2npnA-2i1yA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i7n | PANTOTHENATE KINASE1 (Homo sapiens) |
PF03630(Fumble) | 5 | THR A 442GLY A 445LEU A 450LEU A 438THR A 521 | None | 1.19A | 2npnA-2i7nA:2.3 | 2npnA-2i7nA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i7p | PANTOTHENATE KINASE3 (Homo sapiens) |
PF03630(Fumble) | 5 | THR A 217GLY A 220LEU A 225LEU A 213THR A 296 | None | 1.20A | 2npnA-2i7pA:2.3 | 2npnA-2i7pA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3r | ZGC 92866 (Danio rerio) |
PF04051(TRAPP) | 5 | GLY B 144THR B 143ALA B 140LEU B 137THR B 168 | NoneNoneNO3 B1177 (-3.1A)NoneNO3 B1177 ( 3.7A) | 1.26A | 2npnA-2j3rB:undetectable | 2npnA-2j3rB:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3w | ZGC 92866 (Danio rerio) |
PF04051(TRAPP) | 5 | GLY B 144THR B 143ALA B 140LEU B 137THR B 168 | None | 1.26A | 2npnA-2j3wB:undetectable | 2npnA-2j3wB:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kbe | ATP-DEPENDENT RNAHELICASE DBP5 (Saccharomycescerevisiae) |
PF00270(DEAD) | 5 | GLY A 143THR A 145ALA A 147LEU A 123LEU A 150 | None | 1.15A | 2npnA-2kbeA:undetectable | 2npnA-2kbeA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2klo | DNA REPLICATIONFACTOR CDT1 (Mus musculus) |
PF16679(CDT1_C) | 5 | GLY A 124LEU A 122THR A 126LEU A 116LEU A 98 | None | 1.18A | 2npnA-2kloA:undetectable | 2npnA-2kloA:21.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2npn | PUTATIVE COBALAMINSYNTHESIS RELATEDPROTEIN (Corynebacteriumdiphtheriae) |
PF00590(TP_methylase) | 7 | LEU A 114TYR A 115THR A 142ALA A 143LEU A 185LEU A 147THR A 243 | SAM A4633 (-4.1A)NoneSAM A4633 (-4.0A)SAM A4633 (-3.5A)SAM A4633 (-4.2A)NoneSAM A4633 (-3.9A) | 1.50A | 2npnA-2npnA:39.8 | 2npnA-2npnA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2npn | PUTATIVE COBALAMINSYNTHESIS RELATEDPROTEIN (Corynebacteriumdiphtheriae) |
PF00590(TP_methylase) | 6 | THR A 11GLY A 10THR A 142ALA A 143LEU A 207THR A 243 | SAM A4633 (-4.4A)NoneSAM A4633 (-4.0A)SAM A4633 (-3.5A)SAM A4633 (-3.6A)SAM A4633 (-3.9A) | 1.13A | 2npnA-2npnA:39.8 | 2npnA-2npnA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2npn | PUTATIVE COBALAMINSYNTHESIS RELATEDPROTEIN (Corynebacteriumdiphtheriae) |
PF00590(TP_methylase) | 9 | THR A 11GLY A 110LEU A 114TYR A 115THR A 142ALA A 143LEU A 185LEU A 207THR A 243 | SAM A4633 (-4.4A)SAM A4633 (-3.5A)SAM A4633 (-4.1A)NoneSAM A4633 (-4.0A)SAM A4633 (-3.5A)SAM A4633 (-4.2A)SAM A4633 (-3.6A)SAM A4633 (-3.9A) | 0.00A | 2npnA-2npnA:39.8 | 2npnA-2npnA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og7 | ASPARAGINE OXYGENASE (Streptomycescoelicolor) |
PF02668(TauD) | 5 | GLY A 115THR A 112ALA A 113LEU A 110THR A 306 | None | 1.30A | 2npnA-2og7A:undetectable | 2npnA-2og7A:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogj | DIHYDROOROTASE (Agrobacteriumfabrum) |
PF01979(Amidohydro_1) | 5 | THR A 362ALA A 361LEU A 311LEU A 359THR A 306 | None | 1.13A | 2npnA-2ogjA:undetectable | 2npnA-2ogjA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogx | MOLYBDENUM STORAGEPROTEIN SUBUNITALPHA (Azotobactervinelandii) |
PF00696(AA_kinase) | 5 | THR A 144GLY A 124LEU A 120ALA A 146LEU A 141 | None | 1.07A | 2npnA-2ogxA:2.5 | 2npnA-2ogxA:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p88 | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Bacillus cereus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 48THR A 98ALA A 99LEU A 70THR A 65 | None | 1.06A | 2npnA-2p88A:undetectable | 2npnA-2p88A:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfk | 6-PHOSPHOFRUCTOKINASE ISOZYME I (Escherichiacoli) |
PF00365(PFK) | 5 | THR A 113GLY A 280LEU A 275LEU A 122LEU A 112 | None | 1.28A | 2npnA-2pfkA:2.5 | 2npnA-2pfkA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pnn | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 1 (Rattusnorvegicus) |
PF12796(Ank_2) | 5 | GLY A 316LEU A 313TYR A 309LEU A 291THR A 286 | GLY A 316 ( 0.0A)LEU A 313 ( 0.5A)TYR A 309 ( 1.3A)LEU A 291 ( 0.6A)THR A 286 ( 0.8A) | 1.03A | 2npnA-2pnnA:undetectable | 2npnA-2pnnA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qu7 | PUTATIVETRANSCRIPTIONALREGULATOR (Staphylococcussaprophyticus) |
PF13407(Peripla_BP_4) | 5 | LEU A 183THR A 250ALA A 249LEU A 239LEU A 255 | None | 1.25A | 2npnA-2qu7A:3.9 | 2npnA-2qu7A:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2veo | LIPASE A (Moesziomycesantarcticus) |
PF03583(LIP) | 5 | THR A 123TYR A 105THR A 118ALA A 119LEU A 108 | None | 1.17A | 2npnA-2veoA:2.1 | 2npnA-2veoA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zu6 | PROGRAMMED CELLDEATH PROTEIN 4 (Homo sapiens) |
PF02847(MA3) | 5 | GLY B 270LEU B 274TYR B 278ALA B 266LEU B 301 | None | 0.89A | 2npnA-2zu6B:undetectable | 2npnA-2zu6B:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bc8 | O-PHOSPHOSERYL-TRNA(SEC) SELENIUMTRANSFERASE (Mus musculus) |
PF05889(SepSecS) | 5 | GLY A 45LEU A 329TYR A 334LEU A 128LEU A 35 | None | 1.08A | 2npnA-3bc8A:undetectable | 2npnA-3bc8A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdk | SUCCINYL-COA:3-KETOACID-COENZYME ATRANSFERASE SUBUNITB (Bacillussubtilis) |
PF01144(CoA_trans) | 5 | GLY B 164THR B 163ALA B 114LEU B 171LEU B 160 | None | 1.29A | 2npnA-3cdkB:undetectable | 2npnA-3cdkB:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cjy | PUTATIVETHIOESTERASE (Novosphingobiumaromaticivorans) |
PF13622(4HBT_3) | 5 | GLY A 250THR A 249ALA A 248LEU A 44LEU A 247 | None | 1.30A | 2npnA-3cjyA:undetectable | 2npnA-3cjyA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fed | GLUTAMATECARBOXYPEPTIDASE III (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | THR A 68LEU A 551TYR A 556THR A 548ALA A 375 | NoneNoneNAG A1758 (-3.4A)NoneNone | 1.26A | 2npnA-3fedA:undetectable | 2npnA-3fedA:15.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fww | BIFUNCTIONAL PROTEINGLMU (Yersinia pestis) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 5 | THR A 170GLY A 171LEU A 102LEU A 118THR A 113 | None | 1.22A | 2npnA-3fwwA:undetectable | 2npnA-3fwwA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h8f | CYTOSOLAMINOPEPTIDASE (Pseudomonasputida) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 5 | THR A 15LEU A 74THR A 17ALA A 108LEU A 112 | None | 1.27A | 2npnA-3h8fA:3.0 | 2npnA-3h8fA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE LARGEMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | GLY A 40ALA A 106LEU A 253LEU A 37THR A 258 | None | 1.31A | 2npnA-3hrdA:undetectable | 2npnA-3hrdA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3im7 | CARDIAC CA2+ RELEASECHANNEL (Mus musculus) |
PF08709(Ins145_P3_rec) | 5 | GLY A 116THR A 161ALA A 118LEU A 69LEU A 78 | None | 1.19A | 2npnA-3im7A:undetectable | 2npnA-3im7A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwa | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE (Desulfovibriovulgaris) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 292LEU A 120ALA A 290LEU A 269THR A 283 | None | 1.17A | 2npnA-3iwaA:undetectable | 2npnA-3iwaA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k33 | DEATH ON CURINGPROTEIN (Escherichiavirus P1) |
PF02661(Fic) | 5 | THR A 62THR A 75ALA A 76LEU A 59THR A 101 | None | 1.25A | 2npnA-3k33A:undetectable | 2npnA-3k33A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kkc | TETR FAMILYTRANSCRIPTIONALREGULATOR (Streptococcusagalactiae) |
PF00440(TetR_N)PF14278(TetR_C_8) | 5 | GLY A 42TYR A 50ALA A 39LEU A 56LEU A 38 | None | 1.30A | 2npnA-3kkcA:undetectable | 2npnA-3kkcA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myv | SUSD SUPERFAMILYPROTEIN (Bacteroidesvulgatus) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 5 | THR A 196LEU A 109ALA A 144LEU A 49LEU A 197 | None | 1.08A | 2npnA-3myvA:undetectable | 2npnA-3myvA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nd0 | SLL0855 PROTEIN (Synechocystissp. PCC 6803) |
PF00654(Voltage_CLC) | 5 | THR A 147GLY A 180THR A 183ALA A 184LEU A 403 | None | 1.31A | 2npnA-3nd0A:undetectable | 2npnA-3nd0A:19.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3nd1 | PRECORRIN-6ASYNTHASE/COBFPROTEIN (Rhodobactercapsulatus) |
PF00590(TP_methylase) | 6 | LEU A 117TYR A 118THR A 143ALA A 144LEU A 187LEU A 148 | SAH A 300 (-3.9A)NoneACT A2384 (-3.9A)SAH A 300 (-3.3A)SAH A 300 (-4.6A)None | 1.31A | 2npnA-3nd1A:27.5 | 2npnA-3nd1A:38.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3nd1 | PRECORRIN-6ASYNTHASE/COBFPROTEIN (Rhodobactercapsulatus) |
PF00590(TP_methylase) | 7 | THR A 11GLY A 113LEU A 117TYR A 118THR A 143ALA A 144LEU A 187 | SAH A 300 (-4.4A)SAH A 300 (-3.4A)SAH A 300 (-3.9A)NoneACT A2384 (-3.9A)SAH A 300 (-3.3A)SAH A 300 (-4.6A) | 0.44A | 2npnA-3nd1A:27.5 | 2npnA-3nd1A:38.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nra | ASPARTATEAMINOTRANSFERASE (Rhodobactersphaeroides) |
PF00155(Aminotran_1_2) | 5 | THR A 107GLY A 262THR A 110ALA A 113LEU A 116 | NoneNoneLLP A 252 ( 4.2A)NoneNone | 1.25A | 2npnA-3nraA:undetectable | 2npnA-3nraA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3paj | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE,CARBOXYLATING (Vibrio cholerae) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | THR A 143LEU A 147TYR A 136ALA A 269LEU A 262 | None | 1.09A | 2npnA-3pajA:undetectable | 2npnA-3pajA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnd | THIAMINEBIOSYNTHESISLIPOPROTEIN APBE (Salmonellaenterica) |
PF02424(ApbE) | 5 | GLY A 299TYR A 189ALA A 109LEU A 75LEU A 110 | NoneSO4 A 360 (-4.8A)NoneFAD A 500 ( 4.5A)None | 1.31A | 2npnA-3pndA:undetectable | 2npnA-3pndA:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmt | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE 1 (Bacillushalodurans) |
PF00275(EPSP_synthase) | 5 | GLY A 156LEU A 110THR A 109LEU A 91LEU A 134 | None | 1.19A | 2npnA-3rmtA:undetectable | 2npnA-3rmtA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ss7 | D-SERINE DEHYDRATASE (Escherichiacoli) |
PF00291(PALP) | 5 | GLY X 74LEU X 63TYR X 62THR X 70LEU X 150 | None | 1.31A | 2npnA-3ss7X:1.7 | 2npnA-3ss7X:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4g | NAMN:DMBPHOSPHORIBOSYLTRANSFERASE (Pyrococcushorikoshii) |
no annotation | 5 | GLY A 204THR A 148ALA A 149LEU A 153THR A 228 | None | 1.26A | 2npnA-3u4gA:1.1 | 2npnA-3u4gA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0t | PERAKINE REDUCTASE (Rauvolfiaserpentina) |
PF00248(Aldo_ket_red) | 5 | GLY A 7LEU A 11THR A 173ALA A 174LEU A 175 | None | 0.98A | 2npnA-3v0tA:undetectable | 2npnA-3v0tA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0l | CULLIN-4B (Homo sapiens) |
PF00888(Cullin)PF10557(Cullin_Nedd8) | 5 | THR E 781LEU E 747LEU E 754LEU E 778THR E 771 | None | 1.27A | 2npnA-4a0lE:undetectable | 2npnA-4a0lE:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b4u | BIFUNCTIONAL PROTEINFOLD (Acinetobacterbaumannii) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | THR A 268GLY A 144THR A 141ALA A 140LEU A 269 | None | 1.16A | 2npnA-4b4uA:2.0 | 2npnA-4b4uA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc7 | ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE,PEROXISOMAL (Cavia porcellus) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 5 | GLY A 492TYR A 485ALA A 394LEU A 468LEU A 463 | None | 1.27A | 2npnA-4bc7A:undetectable | 2npnA-4bc7A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bk1 | PROBABLE SALICYLATEMONOOXYGENASE (Rhodococcusjostii) |
PF01494(FAD_binding_3) | 5 | GLY A 221LEU A 219TYR A 217ALA A 71LEU A 68 | NoneNone3HB A1400 (-4.3A)NoneNone | 1.02A | 2npnA-4bk1A:undetectable | 2npnA-4bk1A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3y | 3-KETOSTEROIDDEHYDROGENASE (Rhodococcuserythropolis) |
PF00890(FAD_binding_2) | 5 | THR A 455GLY A 459ALA A 474LEU A 453THR A 478 | None | 1.25A | 2npnA-4c3yA:undetectable | 2npnA-4c3yA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dyk | AMIDOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | GLY A 353THR A 350ALA A 349LEU A 340THR A 323 | None | 1.22A | 2npnA-4dykA:undetectable | 2npnA-4dykA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f62 | GERANYLTRANSTRANSFERASE (Marinomonas sp.MED121) |
PF00348(polyprenyl_synt) | 5 | THR A 194GLY A 59LEU A 57ALA A 191LEU A 192 | None | 1.08A | 2npnA-4f62A:undetectable | 2npnA-4f62A:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6c | BETA-HEXOSAMINIDASE1 (Burkholderiacenocepacia) |
PF00933(Glyco_hydro_3) | 5 | GLY A 107LEU A 162THR A 104ALA A 105LEU A 336 | None | 1.21A | 2npnA-4g6cA:undetectable | 2npnA-4g6cA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6c | BETA-HEXOSAMINIDASE1 (Burkholderiacenocepacia) |
PF00933(Glyco_hydro_3) | 5 | GLY A 159THR A 104ALA A 103LEU A 82LEU A 152 | None | 1.30A | 2npnA-4g6cA:undetectable | 2npnA-4g6cA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g9k | ROTENONE-INSENSITIVENADH-UBIQUINONEOXIDOREDUCTASE (Saccharomycescerevisiae) |
PF07992(Pyr_redox_2) | 5 | LEU A 285THR A 458ALA A 457LEU A 450THR A 474 | LEU A 285 ( 0.6A)THR A 458 ( 0.8A)ALA A 457 ( 0.0A)LEU A 450 ( 0.6A)THR A 474 ( 0.8A) | 1.22A | 2npnA-4g9kA:undetectable | 2npnA-4g9kA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hds | ARSA (Sporomusa ovata) |
PF02277(DBI_PRT) | 5 | GLY A 142THR A 140ALA A 222LEU A 223THR A 187 | None | 1.00A | 2npnA-4hdsA:undetectable | 2npnA-4hdsA:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4het | HYPOTHETICALGLYCOSIDE HYDROLASE (Bacteroidesthetaiotaomicron) |
PF13201(PCMD) | 5 | THR A 362GLY A 360TYR A 257THR A 195LEU A 363 | None | 1.29A | 2npnA-4hetA:undetectable | 2npnA-4hetA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ia4 | AQUAPORIN (Spinaciaoleracea) |
PF00230(MIP) | 5 | GLY A 129TYR A 122THR A 48ALA A 47THR A 92 | None | 1.20A | 2npnA-4ia4A:undetectable | 2npnA-4ia4A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jb6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Pseudomonasaeruginosa) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 347LEU A 407THR A 168LEU A 241LEU A 160 | None | 1.17A | 2npnA-4jb6A:undetectable | 2npnA-4jb6A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrl | PUTATIVE GLYCOSIDEHYDROLASE (Bacteroidesovatus) |
PF13201(PCMD) | 5 | THR A 363GLY A 361TYR A 258THR A 196LEU A 364 | None | 1.29A | 2npnA-4jrlA:undetectable | 2npnA-4jrlA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k1c | VACUOLAR CALCIUM IONTRANSPORTER (Saccharomycescerevisiae) |
PF01699(Na_Ca_ex) | 5 | GLY A 102LEU A 97THR A 100ALA A 99LEU A 219 | None | 1.31A | 2npnA-4k1cA:undetectable | 2npnA-4k1cA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kh3 | ANTIGEN 43 (Escherichiacoli) |
PF16168(AIDA) | 5 | GLY A 395THR A 379ALA A 380LEU A 421THR A 383 | None | 1.19A | 2npnA-4kh3A:undetectable | 2npnA-4kh3A:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oo2 | CHLOROPHENOL-4-MONOOXYGENASE (Streptomycesglobisporus) |
PF03241(HpaB)PF11794(HpaB_N) | 5 | GLY A 451LEU A 394ALA A 449LEU A 324LEU A 260 | None | 1.03A | 2npnA-4oo2A:undetectable | 2npnA-4oo2A:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9d | BENZOYLFORMATEDECARBOXYLASE (Mycolicibacteriumsmegmatis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | THR A 78GLY A 77THR A 74ALA A 99LEU A 35 | None | 1.27A | 2npnA-4q9dA:1.7 | 2npnA-4q9dA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x2d | FIC FAMILY PROTEINPUTATIVEFILAMENTATIONINDUCED BY CAMPPROTEIN (Clostridioidesdifficile) |
PF02661(Fic) | 5 | LEU A 161TYR A 157LEU A 203LEU A 118THR A 120 | NoneATP A 302 ( 4.8A)ATP A 302 (-3.7A)NoneATP A 302 ( 4.0A) | 1.29A | 2npnA-4x2dA:undetectable | 2npnA-4x2dA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yv7 | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Mycolicibacteriumsmegmatis) |
PF13407(Peripla_BP_4) | 5 | GLY A 253THR A 273ALA A 274LEU A 149THR A 306 | None | 1.03A | 2npnA-4yv7A:2.8 | 2npnA-4yv7A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdl | O-PHOSPHOSERYL-TRNA(SEC) SELENIUMTRANSFERASE (Homo sapiens) |
PF05889(SepSecS) | 5 | GLY A 45LEU A 329TYR A 334LEU A 128LEU A 35 | None | 1.09A | 2npnA-4zdlA:3.0 | 2npnA-4zdlA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zqg | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Moraxellacatarrhalis) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | GLY A 118LEU A 114THR A 141ALA A 142LEU A 125 | None | 1.26A | 2npnA-4zqgA:undetectable | 2npnA-4zqgA:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bqk | ICP27 (Humanalphaherpesvirus1) |
PF05459(Herpes_UL69) | 5 | LEU A 344THR A 382ALA A 383LEU A 390LEU A 436 | None | 1.26A | 2npnA-5bqkA:undetectable | 2npnA-5bqkA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dll | AMINOPEPTIDASE N (Francisellatularensis) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 5 | LEU A 101ALA A 43LEU A 68LEU A 30THR A 138 | None NA A 917 (-3.6A)NoneNone NA A 917 (-3.4A) | 1.19A | 2npnA-5dllA:undetectable | 2npnA-5dllA:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9a | BETA-GALACTOSIDASE (Rahnella sp. R3) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | LEU A 139TYR A 143THR A 87ALA A 86LEU A 73 | None | 1.27A | 2npnA-5e9aA:undetectable | 2npnA-5e9aA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey5 | LBCATS-A (syntheticconstruct) |
PF00290(Trp_syntA) | 5 | THR A 33THR A 24ALA A 25LEU A 78THR A 76 | None | 1.25A | 2npnA-5ey5A:undetectable | 2npnA-5ey5A:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fji | BETA-GLUCOSIDASE (Aspergillusfumigatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | THR A 55TYR A 699ALA A 57LEU A 56THR A 318 | NoneNoneNAG A1001 ( 4.0A)NoneNone | 1.26A | 2npnA-5fjiA:undetectable | 2npnA-5fjiA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5g | PUTATIVE XANTHINEDEHYDROGENASE YAGRMOLYBDENUM-BINDINGSU SUBUNIT (Escherichiacoli) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | GLY B 111LEU B 113THR B 109ALA B 71LEU B 56 | FAD B 321 (-3.3A)NoneNoneFAD B 321 ( 3.8A)None | 1.29A | 2npnA-5g5gB:undetectable | 2npnA-5g5gB:25.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5g | PUTATIVE XANTHINEDEHYDROGENASE YAGRMOLYBDENUM-BINDINGSU SUBUNIT (Escherichiacoli) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | LEU B 113THR B 109ALA B 71LEU B 207LEU B 56 | NoneNoneFAD B 321 ( 3.8A)NoneNone | 1.20A | 2npnA-5g5gB:undetectable | 2npnA-5g5gB:25.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgc | SERPIN (Taeniopygiaguttata) |
PF00079(Serpin) | 5 | GLY A 325LEU A 332THR A 327LEU A 189LEU A 136 | None | 1.18A | 2npnA-5hgcA:undetectable | 2npnA-5hgcA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hi9 | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 2 (Rattusnorvegicus) |
PF00520(Ion_trans)PF12796(Ank_2) | 5 | GLY A 278LEU A 275TYR A 271LEU A 253THR A 248 | None | 1.00A | 2npnA-5hi9A:undetectable | 2npnA-5hi9A:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ju6 | BETA-GLUCOSIDASE (Rasamsoniaemersonii) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | THR A 55TYR A 691ALA A 57LEU A 56THR A 314 | NoneNoneNAG A 901 ( 3.8A)NoneNone | 1.25A | 2npnA-5ju6A:undetectable | 2npnA-5ju6A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ld5 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Atopobiumvaginae) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | THR A 228GLY A 247LEU A 245ALA A 230THR A 170 | GOL A 404 (-4.1A)NoneNoneGOL A 404 (-3.3A)None | 1.11A | 2npnA-5ld5A:undetectable | 2npnA-5ld5A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mln | ALCOHOLDEHYDROGENASE 3 ([Candida]magnoliae) |
no annotation | 5 | GLY A 75LEU A 62LEU A 41LEU A 78THR A 32 | None | 1.30A | 2npnA-5mlnA:undetectable | 2npnA-5mlnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swi | SUGAR HYDROLASE (Streptococcuspneumoniae) |
no annotation | 5 | LEU B 63THR B 214ALA B 213LEU B 123LEU B 226 | None | 1.31A | 2npnA-5swiB:undetectable | 2npnA-5swiB:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1a | MYOSIN HEAVY CHAIN,MUSCLE (Drosophilamelanogaster) |
no annotation | 5 | GLY A 230LEU A 438ALA A 228LEU A 338THR A 331 | None | 1.22A | 2npnA-5w1aA:1.3 | 2npnA-5w1aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x41 | COBALT ABCTRANSPORTERATP-BINDING PROTEIN (Rhodobactercapsulatus) |
PF00005(ABC_tran) | 5 | GLY A 53LEU A 55TYR A 12THR A 54LEU A 21 | None | 1.29A | 2npnA-5x41A:undetectable | 2npnA-5x41A:24.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ape | BIFUNCTIONAL PROTEINFOLD (Helicobacterpylori) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | GLY A 148THR A 145ALA A 144LEU A 134LEU A 274 | NoneNoneGOL A 305 ( 4.5A)NoneGOL A 305 (-4.3A) | 1.28A | 2npnA-6apeA:2.1 | 2npnA-6apeA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bwm | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 2 (Oryctolaguscuniculus) |
no annotation | 5 | GLY A 276LEU A 273TYR A 269LEU A 251THR A 246 | None | 1.08A | 2npnA-6bwmA:undetectable | 2npnA-6bwmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dll | P-HYDROXYBENZOATEHYDROXYLASE (Pseudomonasputida) |
no annotation | 5 | GLY A 285LEU A 301ALA A 303LEU A 16THR A 52 | FAD A 401 (-3.6A) CL A 402 (-4.8A)NoneNoneNone | 1.25A | 2npnA-6dllA:undetectable | 2npnA-6dllA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ejf | - (-) |
no annotation | 5 | GLY J 249TYR J 284ALA J 286LEU J 221LEU J 287 | None | 1.28A | 2npnA-6ejfJ:undetectable | 2npnA-6ejfJ:undetectable |