SIMILAR PATTERNS OF AMINO ACIDS FOR 2NOA_B_3TCB302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijx SECRETED
FRIZZLED-RELATED
SEQUENCE PROTEIN 3

(Mus musculus) 		PF01392
(Fz) 		5 ILE A 116
ALA A  83
ARG A  82
ASP A  51
PHE A  54
 None
 1.25A 2noaB-1ijxA:
undetectable		 2noaB-1ijxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		5 ILE K  26
GLU K  32
LEU K 195
ALA K 208
ARG K 210
 None
None
None
None
IOD  K1917 (-4.5A)
 0.87A 2noaB-1oxxK:
2.1		 2noaB-1oxxK:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		11 ILE A  30
GLU A  53
TRP A  58
LEU A  82
TYR A  86
GLN A  97
ALA A 100
ARG A 104
ARG A 128
ASP A 133
PHE A 137
 DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 ( 4.6A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
 0.49A 2noaB-2a30A:
36.0		 2noaB-2a30A:
92.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		6 TYR A  43
GLN A  54
ARG A  61
ARG A  78
ASP A  83
PHE A  86
 None
DCP  A1202 (-2.9A)
None
DCP  A1202 (-2.8A)
DCP  A1202 (-3.6A)
DCP  A1202 (-3.6A)
 0.54A 2noaB-2jaqA:
23.2		 2noaB-2jaqA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		5 TYR A 157
GLN A  54
ARG A  61
ARG A  78
ASP A  83
 None
DCP  A1202 (-2.9A)
None
DCP  A1202 (-2.8A)
DCP  A1202 (-3.6A)
 1.50A 2noaB-2jaqA:
23.2		 2noaB-2jaqA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		7 ILE A  29
TRP A  57
LEU A  66
TYR A  70
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.79A 2noaB-2jcsA:
26.6		 2noaB-2jcsA:
28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		6 ILE A  47
TRP A  75
LEU A  96
TYR A 100
ARG A 118
ARG A 142
 DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.6A)
DTP  A 301 (-4.5A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.2A)
 0.93A 2noaB-2ocpA:
32.6		 2noaB-2ocpA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		6 ILE A  47
TRP A  75
LEU A  96
TYR A 100
ARG A 118
ASP A 147
 DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.6A)
DTP  A 301 (-4.5A)
DTP  A 301 (-3.1A)
DTP  A 301 (-4.1A)
 1.07A 2noaB-2ocpA:
32.6		 2noaB-2ocpA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		6 ILE A  47
TRP A  75
LEU A  96
TYR A 100
ASP A 147
PHE A 151
 DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.6A)
DTP  A 301 (-4.5A)
DTP  A 301 (-4.1A)
DTP  A 301 (-3.3A)
 0.86A 2noaB-2ocpA:
32.6		 2noaB-2ocpA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		7 ILE A  47
TRP A  75
LEU A  96
TYR A 100
GLN A 111
ARG A 142
PHE A 151
 DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.6A)
DTP  A 301 (-4.5A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
 0.61A 2noaB-2ocpA:
32.6		 2noaB-2ocpA:
44.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  15
LEU A 128
TYR A 124
ARG A 184
PHE A 344
 None
 1.23A 2noaB-3gweA:
undetectable		 2noaB-3gweA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpd HYDROXYETHYLTHIAZOLE
KINASE

(Pyrococcus
horikoshii) 		PF02110
(HK) 		5 ILE A 249
LEU A 200
ALA A  39
ARG A  15
ARG A  12
 None
 1.39A 2noaB-3hpdA:
2.7		 2noaB-3hpdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 ILE A 172
GLU A 123
LEU A 139
ARG A 174
ASP A 179
 GOL  A2006 (-3.9A)
None
None
GOL  A2006 (-4.1A)
None
 1.37A 2noaB-3okyA:
undetectable		 2noaB-3okyA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 GLU A  18
LEU A  25
TYR A 116
ALA A  20
ARG A  47
 None
 1.18A 2noaB-4gp1A:
undetectable		 2noaB-4gp1A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		5 ILE A 679
LEU A 816
GLN A 800
ALA A 811
ASP A 808
 None
 1.23A 2noaB-4h6xA:
undetectable		 2noaB-4h6xA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 ILE A 456
GLN A 498
ARG A 433
ASP A 461
PHE A 460
 None
 1.44A 2noaB-4jhzA:
undetectable		 2noaB-4jhzA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo3 HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF01408
(GFO_IDH_MocA)
PF16490
(Oxidoreduct_C) 		5 GLU A 443
TRP A 442
GLN A 252
ARG A 176
ASP A 249
 None
 1.35A 2noaB-4oo3A:
1.8		 2noaB-4oo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase) 		5 ILE A 198
LEU A 218
ALA A  60
ARG A  83
PHE A  80
 None
 1.29A 2noaB-4qmgA:
undetectable		 2noaB-4qmgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 ILE A  76
GLU A  98
ALA A 247
ASP A  92
PHE A  93
 None
 1.29A 2noaB-4qreA:
undetectable		 2noaB-4qreA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT

(Ovis aries) 		PF00420
(Oxidored_q2) 		5 ILE k  31
GLN k  97
ARG k 104
ARG k 126
ASP k 131
 None
 1.18A 2noaB-5lnkk:
15.9		 2noaB-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT

(Ovis aries) 		PF00420
(Oxidored_q2) 		6 LEU k  79
TYR k  83
GLN k  97
ARG k 104
ARG k 126
ASP k 131
 None
 1.43A 2noaB-5lnkk:
15.9		 2noaB-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 ILE A 815
LEU A 507
ALA A 824
ASP A 618
PHE A 551
 None
 1.50A 2noaB-5wugA:
2.8		 2noaB-5wugA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 ILE w  66
LEU w 114
GLN w 132
ARG w 161
ASP w 166
 None
 1.04A 2noaB-5xtdw:
18.3		 2noaB-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 ILE w  66
LEU w 114
TYR w 118
ARG w 161
ASP w 166
 None
 1.08A 2noaB-5xtdw:
18.3		 2noaB-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 5 LEU A 374
GLN A 304
ALA A 296
ASP A 293
PHE A 292
 None
 1.48A 2noaB-6fhvA:
undetectable		 2noaB-6fhvA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
GLU O  53
LEU O  79
GLN O  97
ARG O 126
PHE O 134
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
None
ADP  O 401 (-3.5A)
ADP  O 401 ( 4.3A)
ADP  O 401 (-3.6A)
 0.94A 2noaB-6g2jO:
undetectable		 2noaB-6g2jO:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
GLU O  53
LEU O  79
TYR O  83
ARG O 126
PHE O 134
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
None
ADP  O 401 (-4.9A)
ADP  O 401 ( 4.3A)
ADP  O 401 (-3.6A)
 0.97A 2noaB-6g2jO:
undetectable		 2noaB-6g2jO:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 ILE O  31
GLU O  53
TYR O  83
ARG O 104
ARG O 126
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
ADP  O 401 (-4.9A)
ADP  O 401 (-4.5A)
ADP  O 401 ( 4.3A)
 1.10A 2noaB-6g2jO:
undetectable		 2noaB-6g2jO:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
LEU O  79
TYR O  83
ARG O 126
ASP O 131
PHE O 134
 ADP  O 401 (-4.0A)
None
ADP  O 401 (-4.9A)
ADP  O 401 ( 4.3A)
None
ADP  O 401 (-3.6A)
 0.98A 2noaB-6g2jO:
undetectable		 2noaB-6g2jO:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 ILE O  31
TYR O  83
ARG O 104
ARG O 126
ASP O 131
 ADP  O 401 (-4.0A)
ADP  O 401 (-4.9A)
ADP  O 401 (-4.5A)
ADP  O 401 ( 4.3A)
None
 1.09A 2noaB-6g2jO:
undetectable		 2noaB-6g2jO:
13.93