SIMILAR PATTERNS OF AMINO ACIDS FOR 2NO6_B_ETVB302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		11 ILE A  30
GLU A  53
TRP A  58
LEU A  82
MET A  85
TYR A  86
GLN A  97
ARG A 104
ARG A 128
ASP A 133
PHE A 137
 DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
 0.58A 2no6B-2a30A:
36.0		 2no6B-2a30A:
92.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		6 TYR A  43
GLN A  54
ARG A  61
ARG A  78
ASP A  83
PHE A  86
 None
DCP  A1202 (-2.9A)
None
DCP  A1202 (-2.8A)
DCP  A1202 (-3.6A)
DCP  A1202 (-3.6A)
 0.55A 2no6B-2jaqA:
23.2		 2no6B-2jaqA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		8 ILE A  29
TRP A  57
LEU A  66
MET A  69
TYR A  70
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.74A 2no6B-2jcsA:
26.8		 2no6B-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 ILE A 275
LEU A 231
MET A 237
ARG A  80
ASP A 282
 None
 1.41A 2no6B-2o1bA:
0.5		 2no6B-2o1bA:
23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 ILE A  47
TRP A  75
LEU A  96
ARG A 118
ARG A 142
 DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.6A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.2A)
 0.96A 2no6B-2ocpA:
32.5		 2no6B-2ocpA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 ILE A  47
TRP A  75
LEU A  96
ARG A 118
ASP A 147
 DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.6A)
DTP  A 301 (-3.1A)
DTP  A 301 (-4.1A)
 1.11A 2no6B-2ocpA:
32.5		 2no6B-2ocpA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		7 ILE A  47
TRP A  75
LEU A  96
MET A  99
TYR A 100
ASP A 147
PHE A 151
 DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.6A)
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-4.1A)
DTP  A 301 (-3.3A)
 0.90A 2no6B-2ocpA:
32.5		 2no6B-2ocpA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		8 ILE A  47
TRP A  75
LEU A  96
MET A  99
TYR A 100
GLN A 111
ARG A 142
PHE A 151
 DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.6A)
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
 0.63A 2no6B-2ocpA:
32.5		 2no6B-2ocpA:
44.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE

(Bacillus
subtilis) 		no annotation 5 GLU A 150
LEU A  42
MET A  30
TYR A  32
GLN A  28
 ARS  A1176 (-4.1A)
None
None
None
None
 1.29A 2no6B-2y0oA:
undetectable		 2no6B-2y0oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  15
LEU A 128
TYR A 124
ARG A 184
PHE A 344
 None
 1.25A 2no6B-3gweA:
undetectable		 2no6B-3gweA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 ILE A 172
GLU A 123
LEU A 139
ARG A 174
ASP A 179
 GOL  A2006 (-3.9A)
None
None
GOL  A2006 (-4.1A)
None
 1.39A 2no6B-3okyA:
0.0		 2no6B-3okyA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 ILE A 456
GLN A 498
ARG A 433
ASP A 461
PHE A 460
 None
 1.42A 2no6B-4jhzA:
0.0		 2no6B-4jhzA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo3 HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF01408
(GFO_IDH_MocA)
PF16490
(Oxidoreduct_C) 		5 GLU A 443
TRP A 442
GLN A 252
ARG A 176
ASP A 249
 None
 1.36A 2no6B-4oo3A:
undetectable		 2no6B-4oo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		5 ILE A 691
GLU A1069
MET A1061
ARG A1122
PHE A1123
 None
 1.49A 2no6B-4pj3A:
undetectable		 2no6B-4pj3A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		5 GLU A 308
LEU A 287
MET A 290
ARG A 320
ASP A 312
 None
 1.49A 2no6B-5dpdA:
undetectable		 2no6B-5dpdA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT

(Ovis aries) 		PF00420
(Oxidored_q2) 		5 ILE k  31
GLN k  97
ARG k 104
ARG k 126
ASP k 131
 None
 1.18A 2no6B-5lnkk:
16.1		 2no6B-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT

(Ovis aries) 		PF00420
(Oxidored_q2) 		6 LEU k  79
TYR k  83
GLN k  97
ARG k 104
ARG k 126
ASP k 131
 None
 1.38A 2no6B-5lnkk:
16.1		 2no6B-5lnkk:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 ILE A 767
LEU A 839
MET A 843
ASP A 795
PHE A 796
 None
 1.21A 2no6B-5t8vA:
undetectable		 2no6B-5t8vA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 ILE w  66
LEU w 114
GLN w 132
ARG w 161
ASP w 166
 None
 0.99A 2no6B-5xtdw:
18.4		 2no6B-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 ILE w  66
LEU w 114
TYR w 118
ARG w 161
ASP w 166
 None
 1.02A 2no6B-5xtdw:
18.4		 2no6B-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 7 ILE O  31
GLU O  53
LEU O  79
TYR O  83
ARG O 126
ASP O 131
PHE O 134
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
None
ADP  O 401 (-4.9A)
ADP  O 401 ( 4.3A)
None
ADP  O 401 (-3.6A)
 1.12A 2no6B-6g2jO:
undetectable		 2no6B-6g2jO:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 7 ILE O  31
GLU O  53
LEU O  79
TYR O  83
GLN O  97
ARG O 126
PHE O 134
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
None
ADP  O 401 (-4.9A)
ADP  O 401 (-3.5A)
ADP  O 401 ( 4.3A)
ADP  O 401 (-3.6A)
 1.01A 2no6B-6g2jO:
undetectable		 2no6B-6g2jO:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
GLU O  53
TYR O  83
ARG O 104
ARG O 126
ASP O 131
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
ADP  O 401 (-4.9A)
ADP  O 401 (-4.5A)
ADP  O 401 ( 4.3A)
None
 1.25A 2no6B-6g2jO:
undetectable		 2no6B-6g2jO:
13.93