SIMILAR PATTERNS OF AMINO ACIDS FOR 2NNH_B_9CRB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)

(Rattus
norvegicus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 SER A  62
ILE A  52
ILE A 102
LEU A 131
VAL A 146
 None
 1.23A 2nnhB-1bu8A:
0.0		 2nnhB-1bu8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		5 SER A 110
ILE A 112
ILE A 116
LEU A 281
ASN A 307
 None
 1.03A 2nnhB-1dhsA:
0.5		 2nnhB-1dhsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		5 SER A 110
ILE A 112
LEU A 281
ASN A 307
VAL A 286
 None
 0.94A 2nnhB-1dhsA:
0.5		 2nnhB-1dhsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 ILE A 188
ILE A  49
LEU A  97
ASN A  99
VAL A  30
 None
 1.26A 2nnhB-1e19A:
0.0		 2nnhB-1e19A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epb EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		5 ILE A  18
ILE A 147
LEU A 128
ASN A 130
ILE A  99
 None
 1.16A 2nnhB-1epbA:
0.0		 2nnhB-1epbA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpl RP2 LIPASE

(Cavia porcellus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 SER A  62
ILE A  52
ILE A 102
LEU A 131
VAL A 146
 None
 1.25A 2nnhB-1gplA:
0.0		 2nnhB-1gplA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 ILE A  85
ILE A  96
LEU A 136
ASN A 138
VAL A 163
 None
 1.18A 2nnhB-1pujA:
0.0		 2nnhB-1pujA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqr 3-DEHYDROQUINATE
DEHYDRATASE

(Actinobacillus
pleuropneumoniae) 		PF01220
(DHquinase_II) 		5 ILE A  31
ASN A   8
LEU A   6
VAL A  99
ILE A   4
 None
 1.23A 2nnhB-1uqrA:
undetectable		 2nnhB-1uqrA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 SER X  64
ILE X  53
ILE X 104
LEU X 133
VAL X 148
 None
 1.19A 2nnhB-1w52X:
0.0		 2nnhB-1w52X:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xaj 3-DEHYDROQUINATE
SYNTHASE

(Staphylococcus
aureus) 		PF01761
(DHQ_synthase) 		5 ILE A 172
ILE A 126
LEU A 207
ASN A 208
ILE A 203
 None
 1.22A 2nnhB-1xajA:
0.0		 2nnhB-1xajA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ILE A 398
ILE A 181
LEU A 306
ASN A 369
ILE A 372
 None
 1.19A 2nnhB-1yfmA:
undetectable		 2nnhB-1yfmA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1

(Enterococcus
faecalis) 		PF04962
(KduI) 		5 ILE A1059
ILE A1126
LEU A1037
ASN A1000
VAL A1029
 None
 1.24A 2nnhB-1ywkA:
undetectable		 2nnhB-1ywkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 ILE A 315
ILE A 274
LEU A 344
VAL A 224
ILE A 355
 None
 1.23A 2nnhB-1z6rA:
undetectable		 2nnhB-1z6rA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae6 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		5 SER A 110
ILE A 112
ILE A 161
LEU A 115
ILE A  65
 None
 1.24A 2nnhB-2ae6A:
undetectable		 2nnhB-2ae6A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 SER A 108
ILE A 144
ILE A 145
LEU A 141
VAL A  42
 None
 1.07A 2nnhB-2eb0A:
1.4		 2nnhB-2eb0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		5 SER A 330
ILE A 322
ILE A 292
LEU A 318
ASN A 317
 None
 1.18A 2nnhB-2gduA:
undetectable		 2nnhB-2gduA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		5 ILE A 221
ILE A 201
LEU A 225
ASN A 220
VAL A 163
 None
 1.11A 2nnhB-2gljA:
undetectable		 2nnhB-2gljA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		5 ILE A  10
ILE A 181
LEU A 160
ASN A 159
VAL A 363
 FAD  A 403 (-4.9A)
None
None
None
None
 0.96A 2nnhB-2gqfA:
undetectable		 2nnhB-2gqfA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh9 THIAMIN
PYROPHOSPHOKINASE

(Candida
albicans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 SER A 130
ILE A  74
LEU A  84
ASN A  82
ILE A 117
 None
 1.22A 2nnhB-2hh9A:
undetectable		 2nnhB-2hh9A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		5 ILE A  84
ILE A  88
ASN A 176
LEU A 180
ASN A 184
 None
 1.26A 2nnhB-2jg7A:
undetectable		 2nnhB-2jg7A:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		7 SER A 100
ILE A 102
ASN A 204
ASN A 209
ASN A 217
VAL A 296
ILE A 476
 None
PLM  A 502 ( 4.1A)
None
None
None
None
225  A 501 ( 3.9A)
 0.64A 2nnhB-2nnjA:
61.9		 2nnhB-2nnjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		8 SER A 100
ILE A 102
ILE A 106
ASN A 204
LEU A 208
ASN A 209
ASN A 217
VAL A 296
 None
PLM  A 502 ( 4.1A)
PLM  A 502 (-4.6A)
None
225  A 501 ( 4.3A)
None
None
None
 0.60A 2nnhB-2nnjA:
61.9		 2nnhB-2nnjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 SER A 271
ILE A 291
ASN A 224
LEU A 231
ASN A 229
 None
 1.24A 2nnhB-2ph5A:
undetectable		 2nnhB-2ph5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 ILE A 242
ILE A 252
LEU A 231
ASN A 232
ASN A 235
 None
 1.12A 2nnhB-2pq6A:
undetectable		 2nnhB-2pq6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		5 ILE A  71
ILE A 103
LEU A  74
ASN A  77
VAL A  51
 None
 0.98A 2nnhB-2pyjA:
undetectable		 2nnhB-2pyjA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 102
ILE A  26
LEU A  18
ASN A  21
ILE A 151
 None
 1.15A 2nnhB-2q27A:
undetectable		 2nnhB-2q27A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 ILE A  32
ILE A  27
LEU A 361
VAL A 401
ILE A 409
 None
 1.01A 2nnhB-2qfvA:
undetectable		 2nnhB-2qfvA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A  61
ILE A 117
LEU A  64
ASN A  67
VAL A 139
 None
 1.16A 2nnhB-2va8A:
undetectable		 2nnhB-2va8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xi7 RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF15518
(L_protein_N) 		5 ILE A  91
ILE A 129
LEU A  45
ASN A  46
VAL A 154
 None
 0.97A 2nnhB-2xi7A:
undetectable		 2nnhB-2xi7A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 ILE A 209
LEU A 248
ASN A 252
ASN A 207
ILE A  23
 None
 1.23A 2nnhB-2xkaA:
undetectable		 2nnhB-2xkaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 ILE A 209
LEU A 248
ASN A 252
VAL A  27
ILE A  23
 None
 1.26A 2nnhB-2xkaA:
undetectable		 2nnhB-2xkaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE

(Plectranthus
scutellarioides) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 149
ILE A 150
LEU A 192
ASN A 195
VAL A 217
 None
 1.24A 2nnhB-3bazA:
undetectable		 2nnhB-3bazA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwk CYSTEINE PROTEASE
FALCIPAIN-3

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		5 ILE A 240
ILE A 159
LEU A 227
ASN A 226
ILE A 210
 None
 1.23A 2nnhB-3bwkA:
undetectable		 2nnhB-3bwkA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyg UNCHARACTERIZED
PROTEIN

(Fervidobacterium
nodosum) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		5 ILE A 229
ILE A 209
ASN A 171
ARG A 115
ILE A 191
 None
 1.20A 2nnhB-3cygA:
undetectable		 2nnhB-3cygA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 ILE A 459
ILE A 514
LEU A 457
ASN A 456
VAL A 480
 None
 1.14A 2nnhB-3ddnA:
undetectable		 2nnhB-3ddnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		5 SER A 222
ILE A 196
ILE A 229
VAL A   6
ILE A 182
 None
 1.22A 2nnhB-3eeiA:
undetectable		 2nnhB-3eeiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 ILE A 363
ILE A 331
LEU A 317
ASN A 348
ILE A 374
 None
None
None
GCP  A 474 (-3.5A)
None
 1.24A 2nnhB-3geiA:
undetectable		 2nnhB-3geiA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 ILE A 209
LEU A 248
ASN A 252
ASN A 207
ILE A  23
 None
 0.98A 2nnhB-3j4sA:
undetectable		 2nnhB-3j4sA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US13

(Plasmodium
falciparum) 		PF00416
(Ribosomal_S13) 		5 ILE S  17
ILE S  69
LEU S  32
ASN S  21
ILE S  38
 None
None
None
None
U  A1864 ( 3.3A)
 1.16A 2nnhB-3j7aS:
undetectable		 2nnhB-3j7aS:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd8 NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		PF02460
(Patched)
PF12349
(Sterol-sensing)
PF16414
(NPC1_N) 		5 SER A 483
ILE A 563
ILE A 410
LEU A 446
ILE A 448
 None
 1.17A 2nnhB-3jd8A:
undetectable		 2nnhB-3jd8A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  81
ILE A  77
LEU A 108
ARG A  68
ILE A  94
 None
None
None
None
QUE  A   1 (-4.6A)
 0.97A 2nnhB-3lm5A:
undetectable		 2nnhB-3lm5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkh INTEGRASE

(Staphylococcus
aureus) 		PF00589
(Phage_integrase) 		5 ILE A  11
ILE A   7
ASN A  15
VAL A 160
ILE A 146
 None
 1.24A 2nnhB-3nkhA:
undetectable		 2nnhB-3nkhA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 ILE A 143
ILE A 145
LEU A 153
ASN A 173
VAL A 168
 None
 1.15A 2nnhB-3p4gA:
undetectable		 2nnhB-3p4gA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		5 ILE A 134
ILE A  86
LEU A  17
ASN A 101
ILE A  98
 None
 1.25A 2nnhB-3rkuA:
undetectable		 2nnhB-3rkuA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0x PEPTIDASE A24B, FLAK
DOMAIN PROTEIN

(Methanococcus
maripaludis) 		PF01478
(Peptidase_A24)
PF06847
(Arc_PepC_II) 		5 ILE A 619
LEU A 605
ASN A 606
ASN A 620
ILE A 597
 None
 1.23A 2nnhB-3s0xA:
undetectable		 2nnhB-3s0xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soj PILE

(Francisella
tularensis) 		no annotation 5 SER A  36
ILE A  33
LEU A 123
ASN A 117
ILE A  97
 None
 1.17A 2nnhB-3sojA:
undetectable		 2nnhB-3sojA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sse 5-METHYLCYTOSINE-SPE
CIFIC RESTRICTION
ENZYME B

(Escherichia
coli) 		PF12102
(DUF3578) 		5 SER A   3
ILE A   4
ILE A   8
LEU A 141
ASN A 143
 None
 1.18A 2nnhB-3sseA:
undetectable		 2nnhB-3sseA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B
ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 ILE B 654
LEU B 614
ASN B 610
ASN A 102
VAL B 667
 None
 1.26A 2nnhB-3u44B:
undetectable		 2nnhB-3u44B:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 ILE A 105
LEU A 157
ASN A 153
ASN A 106
ILE A 152
 None
 1.20A 2nnhB-3ufbA:
undetectable		 2nnhB-3ufbA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		5 SER A  34
ILE A  35
LEU A 294
ASN A 293
ILE A 328
 None
 1.24A 2nnhB-3vvjA:
undetectable		 2nnhB-3vvjA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A

(Saccharomyces
cerevisiae) 		PF16787
(NDC10_II) 		5 ILE A  53
LEU A 132
ASN A 130
ASN A 141
ILE A 146
 None
 1.00A 2nnhB-4acoA:
undetectable		 2nnhB-4acoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 SER A 258
ILE A 195
ASN A 264
ASN A 256
VAL A 326
 None
 1.22A 2nnhB-4akoA:
undetectable		 2nnhB-4akoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8v EXTRACELLULAR
PROTEIN 6

(Passalora fulva) 		PF01476
(LysM) 		5 ILE A 185
ILE A 147
LEU A 156
ASN A 171
ILE A 164
 None
NAG  A1202 (-4.6A)
None
None
NAG  A1200 (-4.1A)
 1.21A 2nnhB-4b8vA:
undetectable		 2nnhB-4b8vA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4z DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		no annotation 5 ILE B 279
ASN B 270
ASN B 309
VAL B 276
ILE B 269
 None
 1.25A 2nnhB-4f4zB:
undetectable		 2nnhB-4f4zB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 ILE A 152
ILE A 151
LEU A 196
VAL A 206
ILE A 198
 None
 1.03A 2nnhB-4gc5A:
undetectable		 2nnhB-4gc5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 SER A 279
ILE A 281
ILE A 301
LEU A 483
ILE A 263
 None
 1.22A 2nnhB-4ha6A:
undetectable		 2nnhB-4ha6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN

(Thermotoga
maritima) 		PF04509
(CheC) 		5 SER A 144
ILE A  39
ILE A  36
VAL A 186
ILE A  58
 None
 1.05A 2nnhB-4hynA:
undetectable		 2nnhB-4hynA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4s BEL BETA-TREFOIL

(Boletus edulis) 		no annotation 5 ILE A  24
LEU A  71
ASN A  93
ASN A  67
ILE A  84
 None
None
LAT  A 201 (-3.1A)
None
LAT  A 201 (-3.9A)
 1.22A 2nnhB-4i4sA:
undetectable		 2nnhB-4i4sA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF06355
(Aegerolysin) 		5 ILE A  65
ILE A  71
LEU A  18
ASN A  37
ASN A  66
 None
 1.26A 2nnhB-4joxA:
undetectable		 2nnhB-4joxA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kun HYPOTHETICAL PROTEIN
LPP1115

(Legionella
pneumophila) 		PF07689
(KaiB) 		5 ILE A  39
LEU A  24
ASN A  23
VAL A  10
ILE A  22
 None
 1.20A 2nnhB-4kunA:
undetectable		 2nnhB-4kunA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljx AT-RICH INTERACTIVE
DOMAIN-CONTAINING
PROTEIN 3A

(Homo sapiens) 		PF01388
(ARID) 		5 ILE A 289
ILE A 342
LEU A 338
ASN A 334
ASN A 290
 None
 1.18A 2nnhB-4ljxA:
undetectable		 2nnhB-4ljxA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		5 ILE A 528
ILE A 438
LEU A 426
ASN A 423
VAL A 471
 None
 1.26A 2nnhB-4p69A:
undetectable		 2nnhB-4p69A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 SER A 291
ILE A 260
LEU A 162
ASN A 163
ILE A 219
 None
 1.25A 2nnhB-4p8rA:
undetectable		 2nnhB-4p8rA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 SER A 254
ILE A 287
ILE A 247
VAL A 186
ILE A 299
 None
 1.15A 2nnhB-4tz0A:
undetectable		 2nnhB-4tz0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens) 		PF03283
(PAE) 		5 ILE A 161
LEU A 121
ASN A 176
ASN A 169
VAL A 225
 None
 1.13A 2nnhB-4uz1A:
undetectable		 2nnhB-4uz1A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN

(Chlamydomonas
reinhardtii) 		PF14779
(BBS1) 		5 ILE B 124
ILE B 126
LEU B 235
ARG B 128
ILE B 246
 None
None
None
None
HG  B1433 ( 4.5A)
 1.17A 2nnhB-4v0nB:
undetectable		 2nnhB-4v0nB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF01946
(Thi4) 		5 ILE A 185
LEU A 225
ASN A 224
ASN A 193
VAL A  40
 None
 1.17A 2nnhB-4y4mA:
undetectable		 2nnhB-4y4mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 ILE A 120
LEU A 116
ASN A 115
ASN A 121
ILE A 114
 None
None
NAI  A 500 ( 4.4A)
None
NAI  A 500 (-3.4A)
 1.05A 2nnhB-4yaiA:
undetectable		 2nnhB-4yaiA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Burkholderia
multivorans) 		PF13407
(Peripla_BP_4) 		5 ILE A 119
ILE A 118
ASN A 122
VAL A  85
ILE A 123
 None
 1.25A 2nnhB-4yleA:
undetectable		 2nnhB-4yleA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 ILE A 242
ILE A 241
LEU A  67
ASN A  69
VAL A  49
 None
 1.09A 2nnhB-4zudA:
undetectable		 2nnhB-4zudA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwl BETAINE-ALDEHYDE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		5 SER A  41
ILE A 190
LEU A 208
ASN A 207
ILE A  13
 None
 1.21A 2nnhB-4zwlA:
undetectable		 2nnhB-4zwlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 SER A2039
ILE A1899
LEU A1903
ASN A1898
ILE A1905
 None
 1.12A 2nnhB-5a22A:
undetectable		 2nnhB-5a22A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 ILE A  91
ILE A 129
LEU A  45
ASN A  46
VAL A 154
 None
 1.09A 2nnhB-5amqA:
undetectable		 2nnhB-5amqA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b19 ASPARTATE RACEMASE

(Picrophilus
torridus) 		PF01177
(Asp_Glu_race) 		5 ILE A 195
ILE A 174
LEU A 121
VAL A 181
ILE A 205
 None
 1.22A 2nnhB-5b19A:
undetectable		 2nnhB-5b19A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 ILE A  50
ILE A  43
LEU A  92
ASN A  93
VAL A 116
 None
 0.89A 2nnhB-5bvqA:
undetectable		 2nnhB-5bvqA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 ILE A  55
ILE A  59
LEU A 395
ASN A 397
ILE A 424
 None
 1.15A 2nnhB-5clwA:
undetectable		 2nnhB-5clwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		5 SER A 108
ILE A 386
ASN A 102
VAL A 415
ILE A  12
 MG  A 804 (-2.8A)
None
MG  A 804 (-3.3A)
None
None
 1.08A 2nnhB-5e3cA:
undetectable		 2nnhB-5e3cA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A 134
ILE A 119
ASN A  52
LEU A  77
ILE A 394
 None
 1.21A 2nnhB-5ei0A:
undetectable		 2nnhB-5ei0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE

(Litopenaeus
vannamei) 		PF00121
(TIM) 		5 ILE A  62
ILE A  60
ASN A  12
VAL A   9
ILE A  93
 None
None
PGA  A 301 (-4.1A)
None
None
 1.18A 2nnhB-5eywA:
undetectable		 2nnhB-5eywA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 5 ILE A 220
ASN A 247
LEU A 249
ASN A 182
ILE A 181
 None
 1.25A 2nnhB-5f9aA:
undetectable		 2nnhB-5f9aA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		5 SER A 344
ILE A 348
ILE A 349
LEU A 359
ILE A 330
 None
 1.21A 2nnhB-5frsA:
undetectable		 2nnhB-5frsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 ILE A  58
ILE A  56
LEU A  89
ASN A 191
VAL A 127
 None
 1.18A 2nnhB-5h3kA:
undetectable		 2nnhB-5h3kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 SER A 860
ILE A 861
LEU A 875
VAL A 888
ILE A 877
 None
 1.18A 2nnhB-5h42A:
undetectable		 2nnhB-5h42A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hns NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		no annotation 5 SER A 483
ILE A 563
ILE A 410
LEU A 446
ILE A 448
 None
 1.17A 2nnhB-5hnsA:
undetectable		 2nnhB-5hnsA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		5 ILE A 798
ILE A 881
LEU A 995
VAL A 892
ILE A 966
 None
 1.17A 2nnhB-5hzrA:
undetectable		 2nnhB-5hzrA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iao BIFUNCTIONAL PROTEIN
PYRR

(Mycobacterium
tuberculosis) 		PF00156
(Pribosyltran) 		5 ILE A  29
ILE A  33
LEU A  66
ASN A  64
VAL A  78
 None
 1.25A 2nnhB-5iaoA:
undetectable		 2nnhB-5iaoA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxb DISKS LARGE HOMOLOG
4,SYNGAP

(Homo sapiens;
Mus musculus) 		PF00595
(PDZ) 		5 ILE A 324
ILE A 356
LEU A 376
ASN A 378
ILE A 374
 None
 1.20A 2nnhB-5jxbA:
undetectable		 2nnhB-5jxbA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ILE A 189
LEU A 178
ASN A 179
VAL A 135
ILE A 200
 None
 1.26A 2nnhB-5k6oA:
undetectable		 2nnhB-5k6oA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT

(Ovis aries) 		no annotation 5 ILE d 214
ILE d  92
LEU d  34
ASN d  36
VAL d  45
 None
 0.99A 2nnhB-5lnkd:
undetectable		 2nnhB-5lnkd:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		5 SER A 352
ILE A 348
ILE A 227
LEU A 373
ASN A 376
 None
 1.25A 2nnhB-5lv9A:
undetectable		 2nnhB-5lv9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o00 GLUTATHIONE
TRANSFERASE URE2P5

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A  77
ASN A  11
LEU A   9
VAL A  37
ILE A  62
 None
 1.18A 2nnhB-5o00A:
undetectable		 2nnhB-5o00A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u22 N2152

(Neocallimastix
frontalis) 		PF01229
(Glyco_hydro_39) 		5 ILE A 411
ILE A 428
LEU A 369
ASN A 368
VAL A 343
 None
 1.21A 2nnhB-5u22A:
undetectable		 2nnhB-5u22A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 5 SER A 486
ILE A 505
ILE A 550
LEU A 525
ASN A 516
 None
 1.25A 2nnhB-5whsA:
undetectable		 2nnhB-5whsA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 326
ILE B 323
LEU B  33
ASN B  32
ILE B  31
 None
 1.21A 2nnhB-6c6lB:
undetectable		 2nnhB-6c6lB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cy1 SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Elizabethkingia
anophelis) 		no annotation 5 ILE A  70
ILE A  66
LEU A  89
ASN A  87
VAL A 310
 None
 1.13A 2nnhB-6cy1A:
undetectable		 2nnhB-6cy1A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dub -

(-) 		no annotation 5 SER A 252
ILE A 249
LEU A 220
VAL A 192
ILE A 187
 None
None
UNX  A 316 ( 4.8A)
UNX  A 316 ( 4.3A)
None
 1.11A 2nnhB-6dubA:
undetectable		 2nnhB-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Streptococcus
pyogenes;
Vibrio cholerae) 		no annotation 5 ILE A 336
ILE A 290
LEU A 300
VAL A 234
ILE A 277
 None
 1.25A 2nnhB-6en3A:
undetectable		 2nnhB-6en3A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 5 SER A 632
ILE A 710
ASN A 590
LEU A 593
ASN A 594
 None
 1.15A 2nnhB-6f2tA:
undetectable		 2nnhB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 5 ILE L 414
ILE L 411
ASN L 400
VAL L 315
ILE L 396
 None
 1.19A 2nnhB-6g2jL:
undetectable		 2nnhB-6g2jL:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 5 ILE E  53
LEU E 132
ASN E 130
ASN E 141
ILE E 146
 None
 1.00A 2nnhB-6gsaE:
undetectable		 2nnhB-6gsaE:
undetectable