SIMILAR PATTERNS OF AMINO ACIDS FOR 2NNH_B_9CRB501
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a2z | PYRROLIDONE CARBOXYLPEPTIDASE (Thermococcuslitoralis) |
PF01470(Peptidase_C15) | 5 | ILE A 23VAL A 168PRO A 169ILE A 77VAL A 79 | None | 1.20A | 2nnhB-1a2zA:undetectable | 2nnhB-1a2zA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1abr | ABRIN-A (Abrusprecatorius) |
PF00161(RIP)PF00652(Ricin_B_lectin) | 5 | GLY A 204SER A 208ILE A 36VAL A 237VAL B 222 | None | 1.22A | 2nnhB-1abrA:undetectable | 2nnhB-1abrA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ccw | PROTEIN (GLUTAMATEMUTASE) (Clostridiumcochlearium) |
PF06368(Met_asp_mut_E) | 5 | GLY B 68THR B 347PRO B 92ILE B 324VAL B 323 | None | 1.30A | 2nnhB-1ccwB:0.0 | 2nnhB-1ccwB:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e8c | UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATELIGASE (Escherichiacoli) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | SER A 292THR A 122VAL A 258ILE A 237VAL A 202 | None | 1.33A | 2nnhB-1e8cA:0.0 | 2nnhB-1e8cA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fez | PHOSPHONOACETALDEHYDE HYDROLASE (Bacillus cereus) |
PF13419(HAD_2) | 5 | GLY A 119ILE A 112THR A 16VAL A 9ILE A 10 | None | 1.23A | 2nnhB-1fezA:0.0 | 2nnhB-1fezA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gju | MALTODEXTRINGLYCOSYLTRANSFERASE (Thermotogamaritima) |
PF00128(Alpha-amylase)PF09083(DUF1923) | 5 | GLY A 611ILE A 608THR A 579VAL A 596ILE A 597 | None | 1.31A | 2nnhB-1gjuA:0.0 | 2nnhB-1gjuA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idu | VANADIUMCHLOROPEROXIDASE (Curvulariainaequalis) |
PF01569(PAP2) | 5 | GLY A 409ILE A 307THR A 314VAL A 415VAL A 423 | None | 1.20A | 2nnhB-1iduA:0.2 | 2nnhB-1iduA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1imv | PIGMENTEPITHELIUM-DERIVEDFACTOR (Homo sapiens) |
PF00079(Serpin) | 5 | GLY A 189ILE A 160THR A 150VAL A 123ILE A 183 | None | 1.36A | 2nnhB-1imvA:0.0 | 2nnhB-1imvA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iy1 | ATP-DEPENDENTMETALLOPROTEASE FTSH (Thermusthermophilus) |
PF00004(AAA) | 5 | GLY A 201ILE A 321VAL A 209ILE A 251VAL A 296 | ADP A 1 (-3.0A)NoneNoneNoneNone | 1.35A | 2nnhB-1iy1A:undetectable | 2nnhB-1iy1A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kuu | CONSERVED PROTEIN (Methanothermobacter) |
PF07826(IMP_cyclohyd) | 5 | GLY A 10ILE A 170THR A 32ILE A 62VAL A 39 | None | 1.17A | 2nnhB-1kuuA:undetectable | 2nnhB-1kuuA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lgf | P450 MONOOXYGENASE (Amycolatopsisorientalis) |
PF00067(p450) | 5 | GLY A 157THR A 359VAL A 151ILE A 122VAL A 123 | None | 1.19A | 2nnhB-1lgfA:29.2 | 2nnhB-1lgfA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llc | L-LACTATEDEHYDROGENASE (Lactobacilluscasei) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 30THR A 149VAL A 27ILE A 123VAL A 124 | None | 1.29A | 2nnhB-1llcA:undetectable | 2nnhB-1llcA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mro | METHYL-COENZYME MREDUCTASE (Methanothermobactermarburgensis) |
PF02240(MCR_gamma) | 5 | GLY C 41ILE C 85THR C 140VAL C 36ILE C 31 | None | 1.34A | 2nnhB-1mroC:undetectable | 2nnhB-1mroC:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1no5 | HYPOTHETICAL PROTEINHI0073 (Haemophilusinfluenzae) |
PF01909(NTP_transf_2) | 5 | GLY A 39SER A 35ILE A 9VAL A 99VAL A 30 | None ZN A 501 ( 4.2A)NoneNoneNone | 1.27A | 2nnhB-1no5A:undetectable | 2nnhB-1no5A:13.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odf | HYPOTHETICAL 33.3KDA PROTEIN INADE3-SER2 INTERGENICREGION (Saccharomycescerevisiae) |
no annotation | 5 | GLY A 160ILE A 207THR A 284ILE A 275VAL A 281 | NoneNoneGOL A 504 (-4.0A)NoneNone | 1.32A | 2nnhB-1odfA:undetectable | 2nnhB-1odfA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r44 | D-ALANYL-D-ALANINEDIPEPTIDASE (Enterococcusfaecium) |
PF01427(Peptidase_M15) | 5 | GLY A 138SER A 156THR A 59VAL A 135PRO A 136 | None | 1.12A | 2nnhB-1r44A:undetectable | 2nnhB-1r44A:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sp3 | CYTOCHROME C,PUTATIVE (Shewanellaoneidensis) |
PF11783(Cytochrome_cB)PF13435(Cytochrome_C554) | 5 | GLY A 369ILE A 337THR A 392VAL A 65ILE A 60 | None | 1.24A | 2nnhB-1sp3A:undetectable | 2nnhB-1sp3A:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sy7 | CATALASE 1 (Neurosporacrassa) |
PF00199(Catalase)PF01965(DJ-1_PfpI)PF06628(Catalase-rel) | 5 | GLY A 729THR A 687VAL A 671ILE A 666VAL A 662 | None | 1.32A | 2nnhB-1sy7A:undetectable | 2nnhB-1sy7A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z8l | GLUTAMATECARBOXYPEPTIDASE II (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | GLY A 533ILE A 373VAL A 584ILE A 398VAL A 399 | None | 1.11A | 2nnhB-1z8lA:undetectable | 2nnhB-1z8lA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjy | R-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacillusbrevis) |
PF13561(adh_short_C2) | 5 | GLY A 51SER A 49VAL A 33ILE A 11VAL A 87 | None | 1.12A | 2nnhB-1zjyA:undetectable | 2nnhB-1zjyA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c06 | KID TOXIN PROTEIN (Escherichiacoli) |
PF02452(PemK_toxin) | 5 | GLY A 86ILE A 80VAL A 25ILE A 27VAL A 28 | None | 1.21A | 2nnhB-2c06A:undetectable | 2nnhB-2c06A:12.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3t | 3-KETOACYL-COATHIOLASE (Pseudomonasfragi) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | GLY C 60SER C 98ILE C 39VAL C 57VAL C 116 | None | 1.16A | 2nnhB-2d3tC:undetectable | 2nnhB-2d3tC:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ef7 | HYPOTHETICAL PROTEINST2348 (Sulfurisphaeratokodaii) |
PF00571(CBS) | 5 | GLY A 108VAL A 41PRO A 46ILE A 39VAL A 38 | None | 1.09A | 2nnhB-2ef7A:undetectable | 2nnhB-2ef7A:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gjt | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE PTPRO (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | GLY A1130ILE A1133VAL A1092ILE A1083VAL A1065 | None | 0.85A | 2nnhB-2gjtA:undetectable | 2nnhB-2gjtA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gp6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Mycobacteriumtuberculosis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 195SER A 110ILE A 412THR A 6ILE A 184 | None | 1.25A | 2nnhB-2gp6A:undetectable | 2nnhB-2gp6A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hi6 | UPF0107 PROTEINAF0055 (Archaeoglobusfulgidus) |
PF01989(DUF126) | 5 | GLY A 93ILE A 81THR A 20ILE A 30VAL A 37 | None | 1.17A | 2nnhB-2hi6A:undetectable | 2nnhB-2hi6A:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hnh | DNA POLYMERASE IIIALPHA SUBUNIT (Escherichiacoli) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | ARG A 362GLY A 365ILE A 348VAL A 404VAL A 515 | None | 1.19A | 2nnhB-2hnhA:undetectable | 2nnhB-2hnhA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwz | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE (Homo sapiens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ARG A 94GLY A 95THR A 236VAL A 92PRO A 93 | None | 1.33A | 2nnhB-2iwzA:undetectable | 2nnhB-2iwzA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ix2 | DNA POLYMERASESLIDING CLAMP B (Sulfolobussolfataricus) |
PF00705(PCNA_N) | 5 | GLY A 224SER A 198ILE A 166VAL A 221VAL A 209 | None | 1.34A | 2nnhB-2ix2A:undetectable | 2nnhB-2ix2A:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j66 | BTRK (Bacilluscirculans) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | GLY A 243ILE A 198THR A 205VAL A 249ILE A 42 | NoneEDO A1418 (-3.9A)NoneNoneNone | 1.29A | 2nnhB-2j66A:undetectable | 2nnhB-2j66A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k22 | PUTATIVEUNCHARACTERIZEDPROTEIN TA0895 (Thermoplasmaacidophilum) |
PF02597(ThiS) | 5 | ILE A 24THR A 73VAL A 2ILE A 81VAL A 60 | None | 1.36A | 2nnhB-2k22A:undetectable | 2nnhB-2k22A:11.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2myf | RRM CONTAININGCYCLOPHILIN (Plasmodiumfalciparum) |
PF00076(RRM_1) | 5 | GLY A 32SER A 29VAL A 54ILE A 37VAL A 39 | None | 1.32A | 2nnhB-2myfA:undetectable | 2nnhB-2myfA:10.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nnj | CYTOCHROME P450 2C8 (Homo sapiens) |
PF00067(p450) | 7 | ARG A 97GLY A 98SER A 100ILE A 113THR A 301ILE A 476VAL A 477 | HEM A 500 (-2.6A)NoneNone225 A 501 ( 4.3A)HEM A 500 ( 3.7A)225 A 501 ( 3.9A)None | 0.93A | 2nnhB-2nnjA:61.9 | 2nnhB-2nnjA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nnj | CYTOCHROME P450 2C8 (Homo sapiens) |
PF00067(p450) | 8 | ARG A 97SER A 100ILE A 113THR A 301VAL A 366PRO A 367ILE A 476VAL A 477 | HEM A 500 (-2.6A)None225 A 501 ( 4.3A)HEM A 500 ( 3.7A)225 A 501 ( 3.7A)225 A 501 ( 4.7A)225 A 501 ( 3.9A)None | 0.67A | 2nnhB-2nnjA:61.9 | 2nnhB-2nnjA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nnj | CYTOCHROME P450 2C8 (Homo sapiens) |
PF00067(p450) | 6 | ARG A 97SER A 103VAL A 366PRO A 367ILE A 476VAL A 477 | HEM A 500 (-2.6A)225 A 501 ( 4.0A)225 A 501 ( 3.7A)225 A 501 ( 4.7A)225 A 501 ( 3.9A)None | 1.12A | 2nnhB-2nnjA:61.9 | 2nnhB-2nnjA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og7 | ASPARAGINE OXYGENASE (Streptomycescoelicolor) |
PF02668(TauD) | 5 | ARG A 79GLY A 80THR A 185VAL A 77VAL A 280 | None | 1.25A | 2nnhB-2og7A:undetectable | 2nnhB-2og7A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2v | BETA-D-HYDROXYBUTYRATE DEHYDROGENASE (Pseudomonasputida) |
PF00106(adh_short) | 5 | GLY A 20ILE A 180THR A 163VAL A 85VAL A 115 | None | 1.07A | 2nnhB-2q2vA:undetectable | 2nnhB-2q2vA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rij | PUTATIVE2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATEN-SUCCINYLTRANSFERASE (Campylobacterjejuni) |
PF14602(Hexapep_2)PF14789(THDPS_M)PF14790(THDPS_N) | 5 | GLY A 275SER A 302ILE A 260THR A 251VAL A 256 | CL A 387 ( 3.8A)NoneNoneNoneNone | 1.36A | 2nnhB-2rijA:undetectable | 2nnhB-2rijA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vfk | AKAP18 DELTA (Homo sapiens) |
PF10469(AKAP7_NLS) | 5 | GLY A 289ILE A 286THR A 207VAL A 160ILE A 200 | None | 1.26A | 2nnhB-2vfkA:undetectable | 2nnhB-2vfkA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ztu | D(-)-3-HYDROXYBUTYRATE DEHYDROGENASE (Pseudomonasfragi) |
PF13561(adh_short_C2) | 5 | GLY A 19ILE A 183THR A 166VAL A 88VAL A 118 | None | 1.02A | 2nnhB-2ztuA:undetectable | 2nnhB-2ztuA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bkx | SAM-DEPENDENTMETHYLTRANSFERASE (Lactobacillusparacasei) |
PF13649(Methyltransf_25) | 5 | GLY A 270ILE A 34VAL A 126ILE A 46VAL A 70 | None | 1.19A | 2nnhB-3bkxA:undetectable | 2nnhB-3bkxA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bmw | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 5 | GLY A 505ILE A 501THR A 564VAL A 546ILE A 538 | None | 1.32A | 2nnhB-3bmwA:undetectable | 2nnhB-3bmwA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3efm | FERRIC ALCALIGINSIDEROPHORE RECEPTOR (Bordetellapertussis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | GLY A 536SER A 538VAL A 57ILE A 132VAL A 150 | None | 0.93A | 2nnhB-3efmA:undetectable | 2nnhB-3efmA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3euc | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE 2 (Cupriaviduspinatubonensis) |
PF00155(Aminotran_1_2) | 5 | GLY A 239ILE A 96VAL A 195ILE A 159VAL A 111 | None | 0.92A | 2nnhB-3eucA:undetectable | 2nnhB-3eucA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmj | FATTY ACID SYNTHASESUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00109(ketoacyl-synt)PF01648(ACPS)PF02801(Ketoacyl-synt_C) | 5 | ARG A1566GLY A1569ILE A1533VAL A1572ILE A1557 | None | 1.31A | 2nnhB-3hmjA:undetectable | 2nnhB-3hmjA:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icu | E3 UBIQUITIN-PROTEINLIGASE RNF128 (Homo sapiens) |
PF02225(PA) | 5 | GLY A 172ILE A 179VAL A 144ILE A 193VAL A 80 | None | 1.25A | 2nnhB-3icuA:undetectable | 2nnhB-3icuA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3igh | UNCHARACTERIZEDMETAL-DEPENDENTHYDROLASE (Pyrococcushorikoshii) |
PF07969(Amidohydro_3) | 5 | GLY X 412SER X 414ILE X 353THR X 317VAL X 277 | None | 1.08A | 2nnhB-3ighX:undetectable | 2nnhB-3ighX:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9q | SHEATH (Pseudomonasaeruginosa) |
PF04984(Phage_sheath_1)PF17482(Phage_sheath_1C) | 5 | GLY A 268ILE A 226VAL A 181ILE A 155VAL A 129 | None | 1.16A | 2nnhB-3j9qA:undetectable | 2nnhB-3j9qA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jy6 | TRANSCRIPTIONALREGULATOR, LACIFAMILY (Lactobacillusbrevis) |
PF13407(Peripla_BP_4) | 5 | GLY A 313ILE A 306PRO A 147ILE A 70VAL A 72 | None | 1.28A | 2nnhB-3jy6A:undetectable | 2nnhB-3jy6A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ne2 | PROBABLE AQUAPORINAQPM (Archaeoglobusfulgidus) |
PF00230(MIP) | 5 | ARG A 95GLY A 94SER A 92VAL A 167ILE A 162 | None | 1.20A | 2nnhB-3ne2A:undetectable | 2nnhB-3ne2A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ono | RIBOSE/GALACTOSEISOMERASE (Vibrioparahaemolyticus) |
PF02502(LacAB_rpiB)PF12408(DUF3666) | 5 | GLY A 90ILE A 129VAL A 68ILE A 3VAL A 33 | None | 1.06A | 2nnhB-3onoA:undetectable | 2nnhB-3onoA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pps | LACCASE (Thielaviaarenaria) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | ARG A 33GLY A 32THR A 69VAL A 35ILE A 78 | None | 1.16A | 2nnhB-3ppsA:undetectable | 2nnhB-3ppsA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q6v | BETA-LACTAMASE (Serratiafonticola) |
PF00753(Lactamase_B) | 5 | GLY A 76ILE A 109THR A 86VAL A 73ILE A 83 | None | 1.11A | 2nnhB-3q6vA:undetectable | 2nnhB-3q6vA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9l | NUCLEOSIDEDIPHOSPHATE KINASE (Giardiaintestinalis) |
PF00334(NDK) | 5 | ARG A 104GLY A 105ILE A 116THR A 6VAL A 82 | None | 1.22A | 2nnhB-3r9lA:undetectable | 2nnhB-3r9lA:16.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tk3 | CYTOCHROME P450 2B4 (Oryctolaguscuniculus) |
PF00067(p450) | 5 | ARG A 98ILE A 114THR A 302VAL A 367PRO A 368 | HEM A 500 (-2.9A)HEM A 500 (-4.0A)CPZ A 501 ( 3.7A)HEM A 500 ( 4.3A)None | 0.69A | 2nnhB-3tk3A:45.9 | 2nnhB-3tk3A:55.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w7b | FORMYLTETRAHYDROFOLATE DEFORMYLASE (Thermusthermophilus) |
PF00551(Formyl_trans_N)PF01842(ACT) | 5 | GLY A 164ILE A 156VAL A 168ILE A 189VAL A 224 | None | 1.24A | 2nnhB-3w7bA:undetectable | 2nnhB-3w7bA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a29 | ENGINEEREDRETRO-ALDOL ENZYMERA95.0 (syntheticconstruct) |
PF00218(IGPS) | 5 | GLY A 153SER A 151THR A 84VAL A 130ILE A 113 | None | 1.33A | 2nnhB-4a29A:undetectable | 2nnhB-4a29A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5a | NUCLEOSIDE-TRIPHOSPHATASE 1 (Toxoplasmagondii) |
PF01150(GDA1_CD39) | 5 | GLY A 574ILE A 285THR A 490PRO A 578ILE A 581 | None | 1.32A | 2nnhB-4a5aA:undetectable | 2nnhB-4a5aA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ags | THIOL-DEPENDENTREDUCTASE 1 (Leishmaniainfantum) |
PF13417(GST_N_3)PF16865(GST_C_5) | 5 | ARG A 314GLY A 315VAL A 312PRO A 313VAL A 327 | NoneEDO A1452 (-3.4A)NoneNoneNone | 1.04A | 2nnhB-4agsA:undetectable | 2nnhB-4agsA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ak1 | BT_4661 (Bacteroidesthetaiotaomicron) |
PF16319(DUF4958) | 5 | GLY A 24SER A 26THR A 144VAL A 110PRO A 109 | None | 1.10A | 2nnhB-4ak1A:undetectable | 2nnhB-4ak1A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d5g | CYCLOHEXANE-1,2-DIONE HYDROLASE (Azoarcus sp.BH72) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ARG A 179GLY A 180VAL A 177PRO A 178ILE A 143 | None | 1.15A | 2nnhB-4d5gA:undetectable | 2nnhB-4d5gA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eys | MCCC FAMILY PROTEIN (Streptococcuspneumoniae) |
PF02016(Peptidase_S66) | 5 | GLY A 325ILE A 245VAL A 322PRO A 323ILE A 162 | None | 1.27A | 2nnhB-4eysA:undetectable | 2nnhB-4eysA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fg0 | POLYPROTEIN (Saint Louisencephalitisvirus) |
PF00869(Flavi_glycoprot)PF02832(Flavi_glycop_C) | 5 | GLY A 321ILE A 324VAL A 375PRO A 377ILE A 384 | None | 1.31A | 2nnhB-4fg0A:undetectable | 2nnhB-4fg0A:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4s | PROTEASOME CHAPERONE1 (Saccharomycescerevisiae) |
PF10450(POC1) | 5 | GLY O 147SER O 143VAL O 33PRO O 34VAL O 30 | None | 1.33A | 2nnhB-4g4sO:undetectable | 2nnhB-4g4sO:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hci | CUPREDOXIN 1 (Bacillusanthracis) |
PF13473(Cupredoxin_1) | 5 | GLY A 124VAL A 47PRO A 56ILE A 45VAL A 44 | None | 1.25A | 2nnhB-4hciA:undetectable | 2nnhB-4hciA:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i8q | PUTATIVE BETAINEALDEHYDEDEHYROGENASE (Solanumlycopersicum) |
PF00171(Aldedh) | 5 | GLY A 156ILE A 213VAL A 172ILE A 169VAL A 114 | None | 1.19A | 2nnhB-4i8qA:undetectable | 2nnhB-4i8qA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3b | M1 FAMILYAMINOPEPTIDASE (Plasmodiumfalciparum) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 5 | GLY A 357THR A 327VAL A 341ILE A 218VAL A 227 | None | 1.32A | 2nnhB-4j3bA:undetectable | 2nnhB-4j3bA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j8l | UNCHARACTERIZEDPROTEIN YHFS (Escherichiacoli) |
PF00155(Aminotran_1_2) | 5 | GLY A 73ILE A 79VAL A 206ILE A 216VAL A 212 | None | 1.18A | 2nnhB-4j8lA:undetectable | 2nnhB-4j8lA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jnq | THIOREDOXINREDUCTASE (Brucellamelitensis) |
PF07992(Pyr_redox_2) | 5 | GLY A 247THR A 239VAL A 152ILE A 205VAL A 224 | None | 1.36A | 2nnhB-4jnqA:undetectable | 2nnhB-4jnqA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lsb | LYASE/MUTASE (Burkholderiacenocepacia) |
PF13714(PEP_mutase) | 5 | ARG A 239GLY A 52SER A 50THR A 191VAL A 209 | CL A 502 (-4.3A)None MG A 501 (-2.5A)NoneNone | 1.22A | 2nnhB-4lsbA:undetectable | 2nnhB-4lsbA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nv7 | ARYLAMINEN-ACETYLTRANSFERASE (Mesorhizobiumjaponicum) |
PF00797(Acetyltransf_2) | 5 | GLY A 50ILE A 258VAL A 208ILE A 273VAL A 274 | None | 1.25A | 2nnhB-4nv7A:undetectable | 2nnhB-4nv7A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nvt | TRIOSEPHOSPHATEISOMERASE (Brucellamelitensis) |
PF00121(TIM) | 5 | GLY A 19THR A 93VAL A 46ILE A 44VAL A 43 | None | 1.26A | 2nnhB-4nvtA:undetectable | 2nnhB-4nvtA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o4x | TBPB (Glaesserellaparasuis) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 5 | GLY A 178ILE A 114VAL A 53PRO A 54VAL A 50 | None | 1.35A | 2nnhB-4o4xA:undetectable | 2nnhB-4o4xA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q73 | PROLINEDEHYDROGENASE (Bradyrhizobiumdiazoefficiens) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 5 | SER A 960ILE A 938VAL A 933ILE A 907VAL A 903 | None | 1.35A | 2nnhB-4q73A:undetectable | 2nnhB-4q73A:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4um8 | INTEGRIN ALPHA-V (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | GLY A 418THR A 582VAL A 440PRO A 439ILE A 441 | SO4 A1598 (-3.7A)NoneNoneNoneNone | 1.32A | 2nnhB-4um8A:undetectable | 2nnhB-4um8A:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wgx | MOLINATE HYDROLASE (Gulosibactermolinativorax) |
PF01979(Amidohydro_1) | 5 | ARG A 242GLY A 245VAL A 238ILE A 210VAL A 212 | None | 1.31A | 2nnhB-4wgxA:undetectable | 2nnhB-4wgxA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wgx | MOLINATE HYDROLASE (Gulosibactermolinativorax) |
PF01979(Amidohydro_1) | 5 | GLY A 245THR A 260VAL A 238ILE A 210VAL A 212 | None | 1.16A | 2nnhB-4wgxA:undetectable | 2nnhB-4wgxA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wp3 | MA1120 (Mycobacteriumavium) |
PF00211(Guanylate_cyc) | 5 | GLY A 106ILE A 144VAL A 109ILE A 57VAL A 56 | None | 1.27A | 2nnhB-4wp3A:undetectable | 2nnhB-4wp3A:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wy4 | SYNAPTOSOMAL-ASSOCIATED PROTEIN 29SYNTAXIN-17VESICLE-ASSOCIATEDMEMBRANE PROTEIN 8 (Homo sapiens) |
PF00957(Synaptobrevin)no annotation | 5 | ARG A 37GLY A 38ILE D 227VAL B 193VAL B 186 | None | 1.24A | 2nnhB-4wy4A:undetectable | 2nnhB-4wy4A:8.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xqk | LLABIII (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII)PF13156(Mrr_cat_2) | 5 | GLY A1079ILE A 900VAL A 881ILE A 877VAL A 874 | None | 1.16A | 2nnhB-4xqkA:undetectable | 2nnhB-4xqkA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4za2 | 2-DEOXY-D-GLUCONATE3-DEHYDROGENASE (Pectobacteriumcarotovorum) |
PF13561(adh_short_C2) | 5 | GLY A 25ILE A 186THR A 169VAL A 90VAL A 120 | None | 1.17A | 2nnhB-4za2A:undetectable | 2nnhB-4za2A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zhj | MG-CHELATASE SUBUNITCHLH (Synechocystissp. PCC 6803) |
PF02514(CobN-Mg_chel)PF11965(DUF3479) | 5 | ARG A1029GLY A1028ILE A1032VAL A 961VAL A1208 | None | 1.36A | 2nnhB-4zhjA:undetectable | 2nnhB-4zhjA:16.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c5g | SPHERULIN-4 (Aspergillusclavatus) |
PF12138(Spherulin4) | 5 | GLY A 194THR A 129VAL A 187ILE A 143VAL A 139 | None | 1.31A | 2nnhB-5c5gA:undetectable | 2nnhB-5c5gA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fyn | PUUMALA VIRUS GNGLYCOPROTEIN (Puumalaorthohantavirus) |
PF01567(Hanta_G1) | 5 | GLY A 43ILE A 46THR A 369PRO A 265ILE A 256 | None | 1.36A | 2nnhB-5fynA:undetectable | 2nnhB-5fynA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gai | PORTAL PROTEIN (Salmonellavirus P22) |
PF16510(P22_portal) | 5 | ILE A 333VAL A 397PRO A 398ILE A 340VAL A 341 | None | 1.07A | 2nnhB-5gaiA:undetectable | 2nnhB-5gaiA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw5 | T-COMPLEX PROTEIN 1SUBUNIT DELTA (Saccharomycescerevisiae) |
PF00118(Cpn60_TCP1) | 5 | ARG d 380GLY d 201ILE d 353THR d 364VAL d 378 | None | 1.05A | 2nnhB-5gw5d:undetectable | 2nnhB-5gw5d:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8y | SULFITE REDUCTASE[FERREDOXIN],CHLOROPLASTIC (Zea mays) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | GLY A 390THR A 213VAL A 339ILE A 313VAL A 298 | None | 1.30A | 2nnhB-5h8yA:undetectable | 2nnhB-5h8yA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5had | PROTEIN ACCUMULATIONAND REPLICATION OFCHLOROPLASTS 6,CHLOROPLASTIC (Arabidopsisthaliana) |
PF13355(DUF4101) | 5 | GLY A 747THR A 780VAL A 784ILE A 682VAL A 683 | NoneEDO A 901 ( 4.5A)NoneNoneNone | 1.21A | 2nnhB-5hadA:undetectable | 2nnhB-5hadA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kf7 | BIFUNCTIONAL PROTEINPUTA (Sinorhizobiummeliloti) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 5 | GLY A1011SER A1016ILE A1000ILE A 989VAL A 985 | None | 1.07A | 2nnhB-5kf7A:undetectable | 2nnhB-5kf7A:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m11 | IMMUNOREACTIVE 84KDANTIGEN PG93 (Porphyromonasgingivalis) |
no annotation | 5 | GLY A 461ILE A 464VAL A 482ILE A 503VAL A 515 | None | 1.11A | 2nnhB-5m11A:undetectable | 2nnhB-5m11A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m60 | BETA-1,3-GLUCANASE (Chaetomiumthermophilum) |
PF12708(Pectate_lyase_3) | 5 | SER A 741ILE A 708THR A 628VAL A 698VAL A 615 | None | 1.13A | 2nnhB-5m60A:undetectable | 2nnhB-5m60A:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | ARG A3655GLY A3658VAL A3653ILE A3662VAL A3648 | None | 1.27A | 2nnhB-5nugA:undetectable | 2nnhB-5nugA:7.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ujp | GLYOXALASE/BLEOMYCINRESISANCEPROTEIN/DIOXYGENASE (Streptomycessp. CB03234) |
PF00903(Glyoxalase) | 5 | GLY A 111ILE A 114THR A 52VAL A 11PRO A 12 | NoneNone CA A 201 (-3.8A)NoneNone | 1.26A | 2nnhB-5ujpA:undetectable | 2nnhB-5ujpA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uwv | L,D-TRANSPEPTIDASE 2 (Mycobacteroidesabscessus) |
no annotation | 5 | GLY B 389ILE B 330THR B 275VAL B 372VAL B 254 | None | 1.11A | 2nnhB-5uwvB:undetectable | 2nnhB-5uwvB:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vdn | GLUTATHIONEOXIDOREDUCTASE (Yersinia pestis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 25SER A 29ILE A 20THR A 285VAL A 305 | FAD A 502 (-3.6A)NoneFAD A 502 (-4.9A)NoneNone | 0.82A | 2nnhB-5vdnA:undetectable | 2nnhB-5vdnA:23.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wbg | CYTOCHROME P450 2B6 (Homo sapiens) |
no annotation | 5 | ARG A 98ILE A 114THR A 302VAL A 367PRO A 368 | HEM A 501 (-2.8A)9ZJ A 502 ( 3.6A)9ZJ A 502 ( 3.9A)9ZJ A 502 ( 4.2A)None | 0.53A | 2nnhB-5wbgA:44.6 | 2nnhB-5wbgA:61.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xap | PROTEIN TRANSLOCASESUBUNIT SECD (Deinococcusradiodurans) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 5 | GLY A 536SER A 538ILE A 541VAL A 526ILE A 569 | None | 1.28A | 2nnhB-5xapA:undetectable | 2nnhB-5xapA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cri | - (-) |
no annotation | 5 | GLY M 330ILE M 341THR M 422VAL M 295ILE M 279 | None | 1.20A | 2nnhB-6criM:undetectable | 2nnhB-6criM:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoq | DIPEPTIDYL PEPTIDASE9 (Homo sapiens) |
no annotation | 5 | GLY A 646SER A 682ILE A 702VAL A 643VAL A 675 | None | 1.14A | 2nnhB-6eoqA:undetectable | 2nnhB-6eoqA:10.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f2d | FLAGELLARBIOSYNTHETIC PROTEINFLIPFLAGELLARBIOSYNTHETIC PROTEINFLIR (Salmonellaenterica) |
no annotation | 5 | ARG A 168ILE A 169PRO F 56ILE F 54VAL F 151 | None | 1.30A | 2nnhB-6f2dA:undetectable | 2nnhB-6f2dA:9.29 |