SIMILAR PATTERNS OF AMINO ACIDS FOR 2NNH_A_9CRA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)


(Physarum
polycephalum)
PF09192
(Act-Frag_cataly)
5 SER A 268
ILE A 269
ILE A 208
ASN A 215
VAL A 198
None
1.05A 2nnhA-1cjaA:
0.0
2nnhA-1cjaA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE


(Homo sapiens)
PF01916
(DS)
5 SER A 110
ILE A 112
ILE A 116
LEU A 281
ASN A 307
None
1.01A 2nnhA-1dhsA:
0.2
2nnhA-1dhsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE


(Homo sapiens)
PF01916
(DS)
5 SER A 110
ILE A 112
LEU A 281
ASN A 307
VAL A 286
None
0.91A 2nnhA-1dhsA:
0.2
2nnhA-1dhsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis)
PF00082
(Peptidase_S8)
5 ILE 1 291
LEU 1 287
ASN 1 292
VAL 1 313
VAL 1 253
None
1.02A 2nnhA-1gt91:
0.0
2nnhA-1gt91:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)


(Pseudomonas sp.
CF600)
PF00682
(HMGL-like)
PF01118
(Semialdhyde_dh)
PF07836
(DmpG_comm)
PF09290
(AcetDehyd-dimer)
5 SER B 163
ILE B 159
SER B 160
ASN B 290
VAL A 322
NAD  B3501 (-4.8A)
None
None
NAD  B3501 (-3.6A)
None
0.93A 2nnhA-1nvmB:
0.0
2nnhA-1nvmB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1


(Pinus taeda)
PF05368
(NmrA)
5 SER A 163
LEU A 227
ASN A 225
VAL A 187
ILE A 179
None
1.05A 2nnhA-1qycA:
0.0
2nnhA-1qycA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvv RIBOFLAVIN SYNTHASE

(Bacillus
subtilis)
no annotation 5 SER A  32
LEU A  78
ASN A 134
VAL A  50
ILE A  26
None
1.06A 2nnhA-1rvvA:
0.0
2nnhA-1rvvA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgw PUTATIVE ABC
TRANSPORTER


(Pyrococcus
furiosus)
PF00005
(ABC_tran)
5 ILE A  58
ILE A  47
LEU A   3
VAL A 148
VAL A  30
None
1.04A 2nnhA-1sgwA:
0.0
2nnhA-1sgwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR


(Homo sapiens)
PF01462
(LRRNT)
PF13306
(LRR_5)
5 SER C 201
ILE C 225
SER C 226
LEU C 244
ILE C 222
None
0.80A 2nnhA-1xwdC:
0.0
2nnhA-1xwdC:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqf HYPOTHETICAL PROTEIN
LMAJ011689


(Leishmania
major)
PF02330
(MAM33)
5 SER A  83
ILE A 104
ILE A  86
LEU A 109
VAL A  70
None
1.06A 2nnhA-1yqfA:
undetectable
2nnhA-1yqfA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4v PEROXIREDOXIN DOT5

(Saccharomyces
cerevisiae)
PF00578
(AhpC-TSA)
5 ILE A  82
SER A  83
ILE A  87
LEU A 152
VAL A  94
None
0.98A 2nnhA-2a4vA:
undetectable
2nnhA-2a4vA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
5 SER A 393
SER A 396
ILE A 399
ASN A 384
LEU A 387
None
None
None
GLC  A1544 (-3.8A)
None
1.01A 2nnhA-2bvmA:
undetectable
2nnhA-2bvmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwj ADENYLATE KINASE 5

(Homo sapiens)
PF00406
(ADK)
5 SER A  54
SER A  57
ILE A  60
LEU A  78
VAL A  70
SO4  A1200 (-4.5A)
None
None
None
None
0.93A 2nnhA-2bwjA:
undetectable
2nnhA-2bwjA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933


(Haemophilus
influenzae)
PF03486
(HI0933_like)
5 ILE A  10
ILE A 181
LEU A 160
ASN A 159
VAL A 363
FAD  A 403 (-4.9A)
None
None
None
None
0.89A 2nnhA-2gqfA:
undetectable
2nnhA-2gqfA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C


(Saccharomyces
cerevisiae)
PF12660
(zf-TFIIIC)
5 ILE A  39
SER A  38
ILE A  37
VAL A 102
ILE A 368
None
0.92A 2nnhA-2j04A:
undetectable
2nnhA-2j04A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis)
PF00696
(AA_kinase)
5 ILE A  32
ILE A  36
LEU A  86
VAL A  46
VAL A  98
None
0.92A 2nnhA-2jjxA:
undetectable
2nnhA-2jjxA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9u GAMMA FILAMIN

(Homo sapiens)
PF00630
(Filamin)
5 SER A  99
ILE A  89
SER A  88
ILE A  53
ASN A  92
None
1.02A 2nnhA-2k9uA:
undetectable
2nnhA-2k9uA:
14.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens)
PF00067
(p450)
6 SER A 100
ASN A 209
ASN A 217
VAL A 237
VAL A 296
ILE A 476
None
None
None
None
None
225  A 501 ( 3.9A)
0.68A 2nnhA-2nnjA:
62.3
2nnhA-2nnjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens)
PF00067
(p450)
9 SER A 100
ILE A 102
ILE A 106
ASN A 204
LEU A 208
ASN A 209
ASN A 217
VAL A 237
VAL A 296
None
PLM  A 502 ( 4.1A)
PLM  A 502 (-4.6A)
None
225  A 501 ( 4.3A)
None
None
None
None
0.59A 2nnhA-2nnjA:
62.3
2nnhA-2nnjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens)
PF00067
(p450)
9 SER A 100
ILE A 102
SER A 103
ILE A 106
ASN A 204
ASN A 209
ASN A 217
VAL A 237
VAL A 296
None
PLM  A 502 ( 4.1A)
225  A 501 ( 4.0A)
PLM  A 502 (-4.6A)
None
None
None
None
None
0.64A 2nnhA-2nnjA:
62.3
2nnhA-2nnjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens)
PF00067
(p450)
7 SER A 100
ILE A 102
SER A 103
ILE A 106
ASN A 217
VAL A 237
ARG A 241
None
PLM  A 502 ( 4.1A)
225  A 501 ( 4.0A)
PLM  A 502 (-4.6A)
None
None
None
1.49A 2nnhA-2nnjA:
62.3
2nnhA-2nnjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A


(Homo sapiens)
PF00076
(RRM_1)
5 ILE A  93
SER A  91
ILE A  94
LEU A  41
ILE A  43
None
A  P  17 ( 2.8A)
None
None
None
1.04A 2nnhA-2nz4A:
undetectable
2nnhA-2nz4A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29)
PF03175
(DNA_pol_B_2)
5 ILE A  71
ILE A 103
LEU A  74
ASN A  77
VAL A  51
None
1.01A 2nnhA-2pyjA:
undetectable
2nnhA-2pyjA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE


(Azospirillum
brasilense)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ILE A  96
LEU A  11
VAL A 148
VAL A 175
ILE A  39
None
1.02A 2nnhA-2q5oA:
undetectable
2nnhA-2q5oA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]


(Saccharomyces
cerevisiae)
PF00180
(Iso_dh)
5 ILE A  32
ILE A  27
LEU A 361
VAL A 401
ILE A 409
None
0.96A 2nnhA-2qfvA:
undetectable
2nnhA-2qfvA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN


(Rattus
norvegicus)
PF00079
(Serpin)
5 SER A  42
SER A  39
ILE A  38
ASN A 169
ILE A 152
None
1.03A 2nnhA-2v95A:
undetectable
2nnhA-2v95A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xi7 RNA POLYMERASE L

(California
encephalitis
orthobunyavirus)
PF15518
(L_protein_N)
5 ILE A  91
ILE A 129
LEU A  45
ASN A  46
VAL A 154
None
1.01A 2nnhA-2xi7A:
undetectable
2nnhA-2xi7A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czx PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE AMIDASE


(Neisseria
meningitidis)
PF01520
(Amidase_3)
5 ILE A 168
ILE A 172
ASN A  34
VAL A  72
VAL A  48
None
1.05A 2nnhA-3czxA:
undetectable
2nnhA-3czxA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
5 ILE A 307
LEU A 283
ASN A 282
ASN A 308
VAL A 236
None
1.05A 2nnhA-3fe3A:
undetectable
2nnhA-3fe3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III


(Xanthomonas
oryzae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ILE A 142
LEU A 137
ASN A   5
VAL A 191
VAL A 198
None
0.96A 2nnhA-3fk5A:
undetectable
2nnhA-3fk5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum)
PF00132
(Hexapep)
5 ILE A 144
SER A 143
ILE A 145
ASN A 192
VAL A 131
None
1.00A 2nnhA-3fscA:
undetectable
2nnhA-3fscA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5o UNCHARACTERIZED
PROTEIN RV2865
UNCHARACTERIZED
PROTEIN RV2866


(Mycobacterium
tuberculosis)
PF02604
(PhdYeFM_antitox)
PF05016
(ParE_toxin)
5 ILE A  71
SER A  70
ILE A  67
LEU B  78
ILE B  90
None
1.04A 2nnhA-3g5oA:
undetectable
2nnhA-3g5oA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcs TNF
RECEPTOR-ASSOCIATED
FACTOR 6


(Homo sapiens)
PF13923
(zf-C3HC4_2)
5 ILE A  98
SER A  97
ILE A  94
LEU A 112
VAL A  81
None
0.96A 2nnhA-3hcsA:
undetectable
2nnhA-3hcsA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hct TNF
RECEPTOR-ASSOCIATED
FACTOR 6


(Homo sapiens)
PF13923
(zf-C3HC4_2)
5 ILE A  98
SER A  97
ILE A  94
LEU A 112
VAL A  81
None
0.98A 2nnhA-3hctA:
undetectable
2nnhA-3hctA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE


(Yersinia pestis)
PF00709
(Adenylsucc_synt)
6 ILE A  56
ILE A  69
LEU A  80
VAL A  73
VAL A 149
ILE A 197
None
1.23A 2nnhA-3hidA:
undetectable
2nnhA-3hidA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4p TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY


(Agrobacterium
fabrum)
PF01037
(AsnC_trans_reg)
PF13412
(HTH_24)
5 ILE A  47
ILE A  38
LEU A  12
VAL A  20
VAL A  27
None
0.99A 2nnhA-3i4pA:
undetectable
2nnhA-3i4pA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN


(Bacillus
thuringiensis)
PF00091
(Tubulin)
5 ILE A 209
LEU A 248
ASN A 252
ASN A 207
ILE A  23
None
0.94A 2nnhA-3j4sA:
undetectable
2nnhA-3j4sA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y BL21
ML43


(Homo sapiens)
PF00829
(Ribosomal_L21p)
no annotation
5 ILE S 195
SER S 197
ILE S 198
ASN b 123
VAL S 136
None
0.99A 2nnhA-3j7yS:
undetectable
2nnhA-3j7yS:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6i T-CADHERIN

(Gallus gallus)
PF00028
(Cadherin)
5 ILE A  25
ILE A   2
ASN A  53
VAL A  91
ILE A  55
None
1.04A 2nnhA-3k6iA:
undetectable
2nnhA-3k6iA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw3 ALANINE RACEMASE

(Bartonella
henselae)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
6 ILE A 285
SER A 284
ILE A 283
LEU A 338
VAL A 321
ILE A  18
None
1.46A 2nnhA-3kw3A:
undetectable
2nnhA-3kw3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A  81
ILE A  77
LEU A 108
ARG A  68
ILE A  94
None
None
None
None
QUE  A   1 (-4.6A)
0.98A 2nnhA-3lm5A:
undetectable
2nnhA-3lm5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmo UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00132
(Hexapep)
PF04613
(LpxD)
5 ILE A 238
ILE A 240
VAL A 244
VAL A 204
ILE A 175
None
1.00A 2nnhA-3pmoA:
undetectable
2nnhA-3pmoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pry HEAT SHOCK PROTEIN
HSP 90-BETA


(Homo sapiens)
PF00183
(HSP90)
5 ILE A 400
ILE A 404
LEU A 386
ASN A 389
VAL A 381
None
0.94A 2nnhA-3pryA:
undetectable
2nnhA-3pryA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3q SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE


(Saccharomyces
cerevisiae)
PF05743
(UEV)
5 ILE A  81
SER A  80
ILE A  69
LEU A 152
VAL A 145
None
1.01A 2nnhA-3r3qA:
undetectable
2nnhA-3r3qA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE


(Campylobacter
jejuni)
PF00709
(Adenylsucc_synt)
5 ILE A  69
LEU A  80
VAL A  73
VAL A 145
ILE A 192
None
1.02A 2nnhA-3r7tA:
undetectable
2nnhA-3r7tA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER


(Haemophilus
influenzae)
PF02395
(Peptidase_S6)
PF03212
(Pertactin)
5 SER A 379
ILE A 381
SER A 308
LEU A 331
ASN A 333
None
1.05A 2nnhA-3syjA:
undetectable
2nnhA-3syjA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9


(Veillonella
parvula)
PF01075
(Glyco_transf_9)
5 ILE A   8
ILE A  91
LEU A  29
ASN A  55
VAL A 143
None
1.01A 2nnhA-3tovA:
undetectable
2nnhA-3tovA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
5 ILE A 369
ILE A 367
LEU A 342
ASN A 341
VAL A 417
None
0.92A 2nnhA-3v4pA:
undetectable
2nnhA-3v4pA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE


(Thermotoga
maritima)
PF00933
(Glyco_hydro_3)
6 ILE A  60
SER A  61
ILE A  34
ASN A 109
VAL A  38
VAL A  71
None
1.39A 2nnhA-3wo8A:
undetectable
2nnhA-3wo8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE


(Vigna radiata)
PF03030
(H_PPase)
5 ILE A  81
SER A  82
ASN A 168
VAL A 631
ILE A 288
None
1.01A 2nnhA-4a01A:
1.9
2nnhA-4a01A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A


(Saccharomyces
cerevisiae)
PF16787
(NDC10_II)
5 ILE A  53
LEU A 132
ASN A 130
ASN A 141
ILE A 146
None
1.02A 2nnhA-4acoA:
undetectable
2nnhA-4acoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA


(Saccharomyces
cerevisiae)
PF00179
(UQ_con)
5 ILE A  80
SER A  96
ILE A  95
VAL A  84
ILE A  53
None
1.02A 2nnhA-4bwfA:
undetectable
2nnhA-4bwfA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA


(Streptococcus
pneumoniae)
PF13306
(LRR_5)
6 ILE A 394
ILE A 392
ASN A 435
LEU A 427
ASN A 430
VAL A 414
None
1.45A 2nnhA-4cp6A:
undetectable
2nnhA-4cp6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3g PSTA

(Staphylococcus
aureus)
PF06153
(CdAMP_rec)
5 ILE A  60
SER A  58
ILE A  56
LEU A  20
VAL A  48
None
1.05A 2nnhA-4d3gA:
undetectable
2nnhA-4d3gA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Bacillus
anthracis)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ILE A 292
ILE A 293
ASN A 154
ASN A 287
VAL A 308
None
0.93A 2nnhA-4dibA:
undetectable
2nnhA-4dibA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7


(Schizosaccharomyces
pombe)
PF01423
(LSM)
5 ILE A  42
ILE A  11
LEU A  19
ASN A  18
VAL C  87
None
1.01A 2nnhA-4emkA:
undetectable
2nnhA-4emkA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri)
PF02655
(ATP-grasp_3)
5 ILE A 100
SER A 101
ILE A 240
LEU A 218
VAL A 172
None
1.03A 2nnhA-4fflA:
undetectable
2nnhA-4fflA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn4 SHORT CHAIN
DEHYDROGENASE


(Sulfolobus
acidocaldarius)
PF13561
(adh_short_C2)
5 ILE A  20
ILE A 230
VAL A 141
VAL A  11
ILE A  48
NAD  A 501 (-4.0A)
None
None
None
None
0.91A 2nnhA-4fn4A:
undetectable
2nnhA-4fn4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo1 LINCOSAMIDE
RESISTANCE PROTEIN


(Staphylococcus
haemolyticus)
PF10706
(Aminoglyc_resit)
5 ILE A  49
ILE A  47
LEU A  27
VAL A   6
ILE A 132
None
1.06A 2nnhA-4fo1A:
undetectable
2nnhA-4fo1A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL


(Mus musculus)
PF00398
(RrnaAD)
5 ILE A 152
ILE A 151
LEU A 196
VAL A 206
ILE A 198
None
0.97A 2nnhA-4gc5A:
undetectable
2nnhA-4gc5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h44 APOCYTOCHROME F

(Nostoc sp. PCC
7120)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
5 ILE C  52
ILE C 127
VAL C 101
VAL C 114
ILE C  20
None
0.94A 2nnhA-4h44C:
undetectable
2nnhA-4h44C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks9 MALONYL-COA
DECARBOXYLASE


(Cupriavidus
metallidurans)
PF05292
(MCD)
PF17408
(MCD_N)
5 ILE A 252
SER A 291
ILE A 290
VAL A 256
ILE A 201
None
1.00A 2nnhA-4ks9A:
undetectable
2nnhA-4ks9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE


(Rhodopseudomonas
palustris)
PF05292
(MCD)
PF17408
(MCD_N)
5 ILE A 236
SER A 275
ILE A 274
VAL A 240
ILE A 184
None
1.01A 2nnhA-4ksaA:
undetectable
2nnhA-4ksaA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l82 RIFEA.00250.A

(Rickettsia
felis)
PF01613
(Flavin_Reduct)
5 ILE A  74
SER A  73
ILE A 117
LEU A  40
VAL A 137
None
0.83A 2nnhA-4l82A:
undetectable
2nnhA-4l82A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2


(Caldanaerobacter
subterraneus)
no annotation 5 ILE B  30
LEU B  53
ASN B  54
VAL B  36
ILE B  81
None
1.04A 2nnhA-4mkiB:
undetectable
2nnhA-4mkiB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
6 SER A 574
ILE A 573
ASN A 529
LEU A 581
VAL A 566
ILE A 583
None
1.49A 2nnhA-4mycA:
0.0
2nnhA-4mycA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogq APOCYTOCHROME F

(Nostoc sp. PCC
7120)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
5 ILE C  52
ILE C 127
VAL C 101
VAL C 114
ILE C  20
None
0.94A 2nnhA-4ogqC:
undetectable
2nnhA-4ogqC:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 ILE A 713
ILE A 617
LEU A 711
ASN A 710
ILE A 629
None
1.06A 2nnhA-4on9A:
undetectable
2nnhA-4on9A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oou BETA-1,4-MANNANASE

(Cryptopygus
antarcticus)
no annotation 5 ILE B 225
SER B 226
ILE B 229
LEU B 131
VAL B 164
None
0.96A 2nnhA-4oouB:
undetectable
2nnhA-4oouB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 ILE A 451
SER A 355
VAL A 515
VAL A 561
ILE A 555
None
1.01A 2nnhA-4tz0A:
undetectable
2nnhA-4tz0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE


(Sphingobium sp.
SYK-6)
PF00106
(adh_short)
5 ILE A 120
LEU A 116
ASN A 115
ASN A 121
ILE A 114
None
None
NAI  A 500 ( 4.4A)
None
NAI  A 500 (-3.4A)
1.03A 2nnhA-4yaiA:
undetectable
2nnhA-4yaiA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvq FATTY ACID-BINDING
PROTEIN


(Pygoscelis
papua)
PF00061
(Lipocalin)
5 ILE A  50
ILE A  43
LEU A  92
ASN A  93
VAL A 116
None
0.88A 2nnhA-5bvqA:
undetectable
2nnhA-5bvqA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2)
5 ILE A 198
SER A 194
ILE A 193
VAL A 477
ILE A 518
None
1.05A 2nnhA-5bxpA:
undetectable
2nnhA-5bxpA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byp PUTATIVE
UNCHARACTERIZED
PROTEIN


(Bacteroides
eggerthii)
PF16585
(Lipocalin_8)
5 ILE A  87
SER A  88
ILE A  89
LEU A 138
ASN A 139
None
1.01A 2nnhA-5bypA:
undetectable
2nnhA-5bypA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Staphylococcus
aureus)
PF13395
(HNH_4)
PF16592
(Cas9_REC)
5 SER A 457
ILE A 461
LEU A   7
VAL A 673
ILE A 708
None
1.03A 2nnhA-5czzA:
1.5
2nnhA-5czzA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5r HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL


(Homo sapiens)
PF13589
(HATPase_c_3)
5 ILE A 253
ILE A 255
LEU A 116
VAL A 211
ILE A 143
None
0.96A 2nnhA-5f5rA:
undetectable
2nnhA-5f5rA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frd CARBOXYLESTERASE
(EST-2)


(Archaeoglobus
fulgidus)
PF12697
(Abhydrolase_6)
6 SER A  75
ILE A  49
ILE A  27
LEU A  51
ASN A  53
VAL A  65
None
1.48A 2nnhA-5frdA:
undetectable
2nnhA-5frdA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis)
PF14592
(Chondroitinas_B)
5 ILE A 216
ILE A 217
ASN A 229
VAL A 202
VAL A 248
None
0.99A 2nnhA-5gkqA:
undetectable
2nnhA-5gkqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 ILE A 331
SER A 330
ILE A 307
LEU A 335
ASN A 337
None
1.06A 2nnhA-5gr8A:
undetectable
2nnhA-5gr8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hci GPN-LOOP GTPASE 1

(Saccharomyces
cerevisiae)
PF03029
(ATP_bind_1)
5 ILE A 104
ILE A   6
LEU A  23
VAL A 252
VAL A 171
None
0.95A 2nnhA-5hciA:
undetectable
2nnhA-5hciA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL


(Homo sapiens)
PF00183
(HSP90)
PF13589
(HATPase_c_3)
5 ILE A 253
ILE A 255
LEU A 116
VAL A 211
ILE A 143
None
0.98A 2nnhA-5hphA:
undetectable
2nnhA-5hphA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL


(Homo sapiens)
PF00183
(HSP90)
PF13589
(HATPase_c_3)
5 ILE A 411
ILE A 379
LEU A 405
ASN A 399
VAL A 391
None
1.02A 2nnhA-5hphA:
undetectable
2nnhA-5hphA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iig VACUOLAR TRANSPORTER
CHAPERONE 4


(Saccharomyces
cerevisiae)
PF03105
(SPX)
PF09359
(VTC)
5 SER A 375
ILE A 374
VAL A 441
VAL A 450
ILE A 208
None
0.96A 2nnhA-5iigA:
2.1
2nnhA-5iigA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldy IG DOMAIN PROTEIN
GROUP 1 DOMAIN
PROTEIN


(Yersinia
pseudotuberculosis)
PF09134
(Invasin_D3)
5 SER A1924
ILE A1871
LEU A1894
ASN A1893
VAL A1947
None
0.88A 2nnhA-5ldyA:
undetectable
2nnhA-5ldyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT


(Ovis aries)
no annotation 5 ILE d 214
ILE d  92
LEU d  34
ASN d  36
VAL d  45
None
0.99A 2nnhA-5lnkd:
undetectable
2nnhA-5lnkd:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq6 VIRULENCE PROTEIN
VSDE


(Salmonella
enterica)
PF05563
(SpvD)
5 ILE A 189
SER A 183
LEU A 190
VAL A 167
ILE A 196
None
1.04A 2nnhA-5lq6A:
undetectable
2nnhA-5lq6A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt1 KINESIN-LIKE PROTEIN

(Homo sapiens)
PF00225
(Kinesin)
5 ILE A 111
ILE A 115
VAL A 212
VAL A 173
ILE A 183
None
1.02A 2nnhA-5lt1A:
undetectable
2nnhA-5lt1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002


(Bacteroides
thetaiotaomicron)
no annotation 5 ILE A 483
ILE A 491
ASN A 541
VAL A 509
ILE A 546
None
0.90A 2nnhA-5mqpA:
undetectable
2nnhA-5mqpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia)
PF00079
(Serpin)
5 SER A  70
SER A  67
ILE A  66
ASN A 197
ILE A 180
None
1.06A 2nnhA-5ncsA:
undetectable
2nnhA-5ncsA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE


(Klebsiella
pneumoniae)
PF01977
(UbiD)
5 ILE A 263
ILE A 265
LEU A 135
VAL A 306
VAL A 174
None
1.03A 2nnhA-5o3mA:
undetectable
2nnhA-5o3mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L25


(Mycolicibacterium
smegmatis)
PF01386
(Ribosomal_L25p)
PF14693
(Ribosomal_TL5_C)
5 SER W 163
ILE W 162
LEU W 170
VAL W 178
VAL W 110
None
1.02A 2nnhA-5o60W:
undetectable
2nnhA-5o60W:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3


(Mus musculus)
PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3)
5 SER B 415
ILE B 383
LEU B 346
ASN B 347
ILE B 348
None
1.04A 2nnhA-5sy7B:
undetectable
2nnhA-5sy7B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szq PROTOCADHERIN
GAMMA-A4


(Mus musculus)
PF00028
(Cadherin)
5 ILE A 392
ILE A 410
LEU A 376
VAL A 321
ILE A 378
None
1.00A 2nnhA-5szqA:
undetectable
2nnhA-5szqA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8e ARGININE KINASE

(Polybetes
pythagoricus)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
5 ILE A 350
ILE A 346
LEU A 287
VAL A 283
VAL A 308
None
1.06A 2nnhA-5u8eA:
undetectable
2nnhA-5u8eA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfa RESPONSE REGULATOR

(Streptococcus
pneumoniae)
no annotation 6 ILE A 114
SER A 115
ILE A 117
LEU A  49
VAL A  98
ARG A 161
None
1.49A 2nnhA-5vfaA:
undetectable
2nnhA-5vfaA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnz TNF
RECEPTOR-ASSOCIATED
FACTOR 6


(Danio rerio)
no annotation 5 ILE A  99
SER A  98
ILE A  95
LEU A 113
VAL A  82
None
1.00A 2nnhA-5vnzA:
undetectable
2nnhA-5vnzA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cy1 SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY


(Elizabethkingia
anophelis)
no annotation 5 ILE A  70
ILE A  66
LEU A  89
VAL A  58
VAL A 310
None
1.02A 2nnhA-6cy1A:
undetectable
2nnhA-6cy1A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-)
no annotation 5 ILE A 354
ILE A 357
LEU A 279
VAL A 252
VAL A 370
None
0.95A 2nnhA-6czaA:
undetectable
2nnhA-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1


(Danio rerio)
no annotation 5 ILE A 426
ILE A 394
LEU A 420
ASN A 414
VAL A 406
None
1.05A 2nnhA-6d14A:
undetectable
2nnhA-6d14A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-)
no annotation 5 ILE E  53
LEU E 132
ASN E 130
ASN E 141
ILE E 146
None
1.02A 2nnhA-6gsaE:
undetectable
2nnhA-6gsaE:
undetectable