SIMILAR PATTERNS OF AMINO ACIDS FOR 2N27_A_4DYA205_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		5 LEU A 112
LEU A 323
MET A 326
VAL A  26
MET A  45
 None
 1.32A 2n27A-1p75A:
0.0		 2n27A-1p75A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 LEU A 115
ILE A 126
MET A 178
LEU A  44
VAL A  50
 None
 1.17A 2n27A-1p88A:
undetectable		 2n27A-1p88A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		5 LEU A 207
ILE A 218
MET A 226
LEU A 109
VAL A  75
 None
 1.32A 2n27A-1t8qA:
undetectable		 2n27A-1t8qA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 LEU A 161
ILE A 153
LEU A 411
VAL A 121
MET A 124
 None
 1.28A 2n27A-1x8vA:
0.0		 2n27A-1x8vA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		5 LEU D 439
MET D 333
MET D 331
LEU D 298
MET D 309
 None
 1.08A 2n27A-2gafD:
0.8		 2n27A-2gafD:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		5 LEU A 116
ILE A 124
LEU A 159
VAL A 146
MET A 144
 None
 1.32A 2n27A-2gmlA:
undetectable		 2n27A-2gmlA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00581
(Rhodanese) 		5 LEU A 297
ILE A 183
MET A 192
LEU A 239
VAL A 221
 None
 1.41A 2n27A-2gwfA:
undetectable		 2n27A-2gwfA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		5 MET A 245
LEU A 359
VAL A 311
MET A 313
MET A 272
 None
 1.24A 2n27A-2hkeA:
0.0		 2n27A-2hkeA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		5 LEU A 145
ILE A 189
LEU A  52
VAL A 101
MET A  98
 None
 1.48A 2n27A-2jakA:
0.1		 2n27A-2jakA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 745
MET A 491
MET A 495
VAL A 659
MET A 662
 None
 1.41A 2n27A-2nztA:
0.0		 2n27A-2nztA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 5 LEU G 304
ILE G 279
MET G 187
LEU G 133
MET G 129
 None
 1.47A 2n27A-2ooxG:
undetectable		 2n27A-2ooxG:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlw RHAU

(Rhizobium
leguminosarum) 		PF05336
(rhaM) 		5 LEU A  31
ILE A  27
MET A  82
MET A  86
LEU A  99
 None
 1.39A 2n27A-2qlwA:
undetectable		 2n27A-2qlwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlx L-RHAMNOSE
MUTAROTASE

(Rhizobium
leguminosarum) 		PF05336
(rhaM) 		5 LEU A  31
ILE A  27
MET A  82
MET A  86
LEU A  99
 None
None
RM4  A 300 ( 4.9A)
RM4  A 300 ( 3.6A)
None
 1.41A 2n27A-2qlxA:
undetectable		 2n27A-2qlxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 THR A 560
ILE A 538
LEU A 618
MET A 615
MET A 638
 None
 1.39A 2n27A-2vycA:
undetectable		 2n27A-2vycA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		5 LEU A  85
THR A  33
ILE A  36
LEU A 234
VAL A  31
 None
None
BME  A 602 (-3.9A)
None
None
 1.47A 2n27A-2w3pA:
0.0		 2n27A-2w3pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		5 ILE A  34
MET A  20
LEU A  63
VAL A  86
MET A  87
 None
 1.47A 2n27A-3beoA:
0.0		 2n27A-3beoA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 107
ILE A 103
MET A 334
LEU A 199
VAL A 212
 None
 1.48A 2n27A-3h5cA:
undetectable		 2n27A-3h5cA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwk METHYLCITRATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		5 LEU A 311
MET A 253
MET A 250
LEU A 181
VAL A 193
 None
 1.02A 2n27A-3hwkA:
undetectable		 2n27A-3hwkA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		5 LEU A  93
THR A   4
ILE A 243
VAL A 340
MET A 341
 None
 1.40A 2n27A-3hxwA:
0.0		 2n27A-3hxwA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in5 DNA POLYMERASE KAPPA

(Homo sapiens) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		5 LEU A 376
ILE A 357
LEU A  99
VAL A 342
MET A 343
 None
 1.33A 2n27A-3in5A:
undetectable		 2n27A-3in5A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 LEU B1573
THR B1602
ILE B1607
MET B1542
LEU B 887
 None
 1.26A 2n27A-3prxB:
undetectable		 2n27A-3prxB:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 LEU A 227
THR A 308
ILE A 237
LEU A 316
VAL A 314
 None
 1.21A 2n27A-3stjA:
undetectable		 2n27A-3stjA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		6 ILE A 321
MET A 365
MET A 366
VAL A 402
MET A 403
MET A 439
 None
 1.20A 2n27A-3u0kA:
3.1		 2n27A-3u0kA:
38.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up8 PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE B

(Sinorhizobium
meliloti) 		PF00248
(Aldo_ket_red) 		5 LEU A 103
THR A 181
ILE A 134
LEU A 213
VAL A 224
 None
 1.46A 2n27A-3up8A:
undetectable		 2n27A-3up8A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 THR A 572
ILE A 771
MET A 755
MET A 752
LEU A 790
 None
 1.15A 2n27A-4lixA:
0.2		 2n27A-4lixA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		5 LEU A  43
ILE A  38
LEU A  90
VAL A  97
MET A  65
 None
 1.45A 2n27A-4m88A:
undetectable		 2n27A-4m88A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		5 LEU A 115
THR A 141
MET A 169
LEU A 246
VAL A 143
 None
 1.47A 2n27A-4m8sA:
undetectable		 2n27A-4m8sA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 LEU A 209
THR A 134
ILE A 145
MET A 267
LEU A 247
 None
 1.47A 2n27A-4ouaA:
0.0		 2n27A-4ouaA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 LEU A 273
ILE A 545
MET A 287
MET A 448
VAL A 323
 None
 1.24A 2n27A-4trqA:
undetectable		 2n27A-4trqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		5 LEU A  95
ILE A 149
MET A  31
LEU A 197
VAL A 106
 None
IOD  A 304 ( 4.7A)
None
None
None
 1.36A 2n27A-4zu2A:
undetectable		 2n27A-4zu2A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep0 PUTATIVE REPRESSOR
PROTEIN LUXO

(Photobacterium
angustum) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 ILE A 323
MET A 149
LEU A  50
VAL A  79
MET A  81
 None
 1.28A 2n27A-5ep0A:
undetectable		 2n27A-5ep0A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eup CENTROSOME-ASSOCIATE
D ZINC FINGER
PROTEIN CP190

(Drosophila
melanogaster) 		PF00651
(BTB) 		5 LEU A 116
THR A 106
LEU A  34
MET A  72
VAL A  81
 None
 1.40A 2n27A-5eupA:
undetectable		 2n27A-5eupA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		5 LEU A 279
THR A   6
ILE A  68
LEU A 178
VAL A 165
 None
 1.41A 2n27A-5gs7A:
undetectable		 2n27A-5gs7A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilb PROTEASE DO-LIKE 2,
CHLOROPLASTIC,PROTEA
SE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 LEU A 489
THR A 450
ILE A 430
LEU A 496
VAL A 448
 None
 1.46A 2n27A-5ilbA:
undetectable		 2n27A-5ilbA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		5 LEU A 103
THR A 321
ILE A 107
MET A  66
LEU A 293
 None
FAD  A 502 (-2.6A)
None
FAD  A 502 (-4.4A)
None
 1.42A 2n27A-5ipyA:
0.0		 2n27A-5ipyA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 MET B  32
MET B 329
LEU B 168
VAL B 231
MET B   9
 None
 1.48A 2n27A-5my0B:
undetectable		 2n27A-5my0B:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		5 ILE A1746
MET A1759
MET A1756
LEU A1620
VAL A1816
 None
 0.88A 2n27A-5mznA:
undetectable		 2n27A-5mznA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 5 LEU A 196
ILE A 224
MET A 185
LEU A  85
MET A 276
 None
 1.35A 2n27A-5obtA:
undetectable		 2n27A-5obtA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v38 HCHA

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 LEU A1036
THR A 988
ILE A 985
MET A 956
VAL A 990
 None
 1.25A 2n27A-5v38A:
undetectable		 2n27A-5v38A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		5 LEU f 692
ILE f 660
LEU f 487
MET f 524
VAL f 801
 None
 1.05A 2n27A-5vhif:
undetectable		 2n27A-5vhif:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 THR H  93
ILE L 112
LEU H  20
MET H  85
VAL H 127
 None
 1.42A 2n27A-5whzH:
undetectable		 2n27A-5whzH:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 5 LEU A 499
THR A 460
ILE A 440
LEU A 506
VAL A 458
 None
 1.46A 2n27A-5y09A:
undetectable		 2n27A-5y09A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 THR A 242
ILE A 273
MET A  23
LEU A 228
VAL A 238
 None
None
None
MES  A 502 (-4.8A)
None
 1.37A 2n27A-6eu6A:
undetectable		 2n27A-6eu6A:
16.67