SIMILAR PATTERNS OF AMINO ACIDS FOR 2M2P_B_DHIB24_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a33 PEPTIDYLPROLYL
ISOMERASE

(Brugia malayi) 		PF00160
(Pro_isomerase) 		3 TYR A  59
GLY A  61
PHE A  78
 None
 0.65A 2m2pB-1a33A:
undetectable		 2m2pB-1a33A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1e CATALYTIC ANTIBODY
1E9 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 185
GLY H 146
PHE H 148
 None
 0.69A 2m2pB-1c1eH:
undetectable		 2m2pB-1c1eH:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		3 TYR A  72
GLY A 111
PHE A 109
 None
 0.70A 2m2pB-1cvrA:
undetectable		 2m2pB-1cvrA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1emt IGG ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 178
GLY H 147
PHE H 149
 None
 0.71A 2m2pB-1emtH:
undetectable		 2m2pB-1emtH:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4w ANTIBODY S-20-4, FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 179
GLY H 148
PHE H 150
 None
 0.72A 2m2pB-1f4wH:
undetectable		 2m2pB-1f4wH:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR B 168
GLY B 137
PHE B 139
 None
 0.65A 2m2pB-1fn4B:
undetectable		 2m2pB-1fn4B:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5

(Caenorhabditis
elegans) 		PF00160
(Pro_isomerase) 		3 TYR A  72
GLY A  74
PHE A  91
 None
 0.68A 2m2pB-1h0pA:
undetectable		 2m2pB-1h0pA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 176
GLY H 144
PHE H 146
 None
 0.72A 2m2pB-1h3pH:
undetectable		 2m2pB-1h3pH:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ist CYCLOPHILIN A

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase) 		3 TYR A  46
GLY A  48
PHE A  65
 None
 0.61A 2m2pB-1istA:
undetectable		 2m2pB-1istA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhk IG GAMMA-1-CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 175
GLY H 144
PHE H 146
 None
 0.70A 2m2pB-1jhkH:
undetectable		 2m2pB-1jhkH:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ken INFLUENZA VIRUS
INFECTIVITY
NEUTRALIZING
ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 182
GLY H 151
PHE H 153
 None
 0.72A 2m2pB-1kenH:
undetectable		 2m2pB-1kenH:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la4 SGTX1

(Stromatopelma
calceatum) 		PF07740
(Toxin_12) 		3 TYR A  27
GLY A   8
PHE A   6
 None
 0.67A 2m2pB-1la4A:
undetectable		 2m2pB-1la4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)

(Homo sapiens) 		PF00681
(Plectin) 		3 TYR A2392
GLY A2395
PHE A2397
 None
 0.69A 2m2pB-1lm7A:
undetectable		 2m2pB-1lm7A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR F 185
GLY F 146
PHE F 148
 None
 0.62A 2m2pB-1nfdF:
undetectable		 2m2pB-1nfdF:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo6 FIBRONECTIN

(Homo sapiens) 		PF00039
(fn1)
PF00040
(fn2) 		3 TYR A  47
GLY A  53
PHE A  96
 None
 0.65A 2m2pB-1qo6A:
undetectable		 2m2pB-1qo6A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoi SNUCYP-20

(Homo sapiens) 		PF00160
(Pro_isomerase) 		3 TYR A  60
GLY A  62
PHE A  79
 None
 0.68A 2m2pB-1qoiA:
undetectable		 2m2pB-1qoiA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrd QUINONE-REDUCTASE

(Rattus rattus) 		PF02525
(Flavodoxin_2) 		3 TYR A 132
GLY A 180
PHE A 178
 None
 0.69A 2m2pB-1qrdA:
undetectable		 2m2pB-1qrdA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		3 TYR A 397
GLY A  36
PHE A  34
 None
 0.36A 2m2pB-1tp7A:
undetectable		 2m2pB-1tp7A:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhn CELLULAR REPRESSOR
OF E1A-STIMULATED
GENES

(Homo sapiens) 		PF13883
(Pyrid_oxidase_2) 		3 TYR A 166
GLY A 169
PHE A 167
 None
 0.64A 2m2pB-1xhnA:
undetectable		 2m2pB-1xhnA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trypanosoma
cruzi) 		PF00160
(Pro_isomerase) 		3 TYR A  50
GLY A  52
PHE A  69
 None
 0.65A 2m2pB-1xq7A:
undetectable		 2m2pB-1xq7A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		3 TYR A 397
GLY A  36
PHE A  34
 None
 0.51A 2m2pB-1xr6A:
undetectable		 2m2pB-1xr6A:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE

(Escherichia
virus T4) 		PF02086
(MethyltransfD12) 		3 TYR A  25
GLY A 165
PHE A 167
 None
 0.57A 2m2pB-1yfjA:
undetectable		 2m2pB-1yfjA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfe ALLERGEN

(Malassezia
sympodialis) 		PF00160
(Pro_isomerase) 		3 TYR A  46
GLY A  48
PHE A  65
 None
 0.67A 2m2pB-2cfeA:
undetectable		 2m2pB-2cfeA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		3 TYR A  36
GLY A 188
PHE A 190
 None
 0.43A 2m2pB-2dpmA:
undetectable		 2m2pB-2dpmA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhg HYPOTHETICAL PROTEIN
RPA3614

(Rhodopseudomonas
palustris) 		PF00581
(Rhodanese) 		3 TYR A  91
GLY A  94
PHE A 120
 None
PO4  A4285 (-3.1A)
None
 0.62A 2m2pB-2hhgA:
undetectable		 2m2pB-2hhgA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
GAMMA-SUBUNIT

(Aromatoleum
aromaticum) 		PF09459
(EB_dh) 		3 TYR C 203
GLY C  53
PHE C  32
 HEM  C1217 (-3.7A)
None
None
 0.69A 2m2pB-2ivfC:
undetectable		 2m2pB-2ivfC:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		3 TYR B 104
GLY A 156
PHE B 103
 None
 0.68A 2m2pB-2ivfB:
undetectable		 2m2pB-2ivfB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		3 TYR A 232
GLY A 236
PHE A 228
 None
 0.70A 2m2pB-2ixnA:
undetectable		 2m2pB-2ixnA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m07 OUTER MEMBRANE
PROTEIN X

(Escherichia
coli) 		PF13505
(OMP_b-brl) 		3 TYR A   9
GLY A  22
PHE A  24
 None
 0.67A 2m2pB-2m07A:
undetectable		 2m2pB-2m07A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		3 TYR A 635
GLY A 619
PHE A 636
 None
 0.72A 2m2pB-2o5pA:
undetectable		 2m2pB-2o5pA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Cryptosporidium
parvum) 		PF00160
(Pro_isomerase) 		3 TYR A  71
GLY A  73
PHE A  90
 None
 0.67A 2m2pB-2poyA:
undetectable		 2m2pB-2poyA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q05 DUAL SPECIFICITY
PROTEIN PHOSPHATASE

(Vaccinia virus) 		PF00782
(DSPc) 		3 TYR A  -4
GLY A  -1
PHE A  -3
 None
 0.62A 2m2pB-2q05A:
undetectable		 2m2pB-2q05A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C

(Mus musculus) 		PF00160
(Pro_isomerase) 		3 TYR A  82
GLY A  84
PHE A 101
 None
 0.62A 2m2pB-2rmcA:
undetectable		 2m2pB-2rmcA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8n LACTOSE PERMEASE

(Escherichia
coli) 		PF01306
(LacY_symp) 		3 TYR A  26
GLY A  24
PHE A  27
 None
 0.67A 2m2pB-2v8nA:
undetectable		 2m2pB-2v8nA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A

(Homo sapiens) 		PF00160
(Pro_isomerase) 		3 TYR B  48
GLY B  50
PHE B  67
 None
 0.63A 2m2pB-2x25B:
undetectable		 2m2pB-2x25B:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		3 TYR A 643
GLY A  69
PHE A 115
 None
 0.71A 2m2pB-3abzA:
undetectable		 2m2pB-3abzA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		3 TYR A  76
GLY A  13
PHE A 401
 None
 0.65A 2m2pB-3ahxA:
undetectable		 2m2pB-3ahxA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfe PUTATIVE PII-LIKE
SIGNALING PROTEIN

(Trichormus
variabilis) 		no annotation 3 TYR A  87
GLY A  89
PHE A  83
 None
 0.64A 2m2pB-3dfeA:
undetectable		 2m2pB-3dfeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg8 UNCHARACTERIZED
PROTEIN RHA05790

(Rhodococcus
jostii) 		PF08448
(PAS_4) 		3 TYR A 174
GLY A 172
PHE A 175
 3PB  A 301 (-4.6A)
None
3PB  A 301 ( 4.2A)
 0.69A 2m2pB-3fg8A:
undetectable		 2m2pB-3fg8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I

(Cytophaga
hutchinsonii) 		PF00425
(Chorismate_bind) 		3 TYR A 217
GLY A 367
PHE A  85
 None
 0.71A 2m2pB-3h9mA:
undetectable		 2m2pB-3h9mA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 TYR A  21
GLY A  24
PHE A 117
 None
 0.71A 2m2pB-3j2iA:
undetectable		 2m2pB-3j2iA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mql FIBRONECTIN 1

(Homo sapiens) 		PF00039
(fn1)
PF00040
(fn2) 		3 TYR A 351
GLY A 357
PHE A 400
 None
 0.69A 2m2pB-3mqlA:
undetectable		 2m2pB-3mqlA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TYR A 233
GLY A  17
PHE A  15
 None
 0.65A 2m2pB-3pqdA:
undetectable		 2m2pB-3pqdA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H

(Bacillus
subtilis) 		PF13176
(TPR_7) 		3 TYR A 297
GLY A 285
PHE A 263
 None
 0.60A 2m2pB-3q15A:
undetectable		 2m2pB-3q15A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc2 GLYCOSYL HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		3 TYR A 300
GLY A 296
PHE A 265
 None
 0.69A 2m2pB-3qc2A:
undetectable		 2m2pB-3qc2A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR F 184
GLY F 153
PHE F 155
 None
 0.71A 2m2pB-3riaF:
undetectable		 2m2pB-3riaF:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 3 TYR N 159
GLY N 144
PHE N 140
 None
 0.68A 2m2pB-3rkoN:
undetectable		 2m2pB-3rkoN:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s88 16F6 - HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 181
GLY H 150
PHE H 152
 None
 0.72A 2m2pB-3s88H:
undetectable		 2m2pB-3s88H:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3taw HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Parabacteroides
distasonis) 		PF04041
(Glyco_hydro_130) 		3 TYR A 306
GLY A 302
PHE A 270
 None
 0.70A 2m2pB-3tawA:
undetectable		 2m2pB-3tawA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		3 TYR A 132
GLY A 180
PHE A 131
 None
 0.66A 2m2pB-3te7A:
undetectable		 2m2pB-3te7A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE

(Leptospirillum
rubarum) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 TYR A 149
GLY A  73
PHE A  75
 None
 0.70A 2m2pB-3ttgA:
undetectable		 2m2pB-3ttgA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 TYR A 652
GLY A 654
PHE A 619
 None
 0.69A 2m2pB-3u4aA:
undetectable		 2m2pB-3u4aA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		3 TYR A 152
GLY A 164
PHE A 166
 None
 0.63A 2m2pB-3vseA:
undetectable		 2m2pB-3vseA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		3 TYR A  95
GLY A 131
PHE A 133
 None
 0.60A 2m2pB-3w4kA:
undetectable		 2m2pB-3w4kA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		3 TYR A 194
GLY A 116
PHE A 118
 None
 0.61A 2m2pB-3wmtA:
undetectable		 2m2pB-3wmtA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		3 TYR A  58
GLY A  36
PHE A  52
 None
 0.70A 2m2pB-3wp5A:
undetectable		 2m2pB-3wp5A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ) 		no annotation 3 TYR A  32
GLY A  13
PHE A  11
 None
GDP  A 999 (-3.6A)
None
 0.71A 2m2pB-3zbqA:
undetectable		 2m2pB-3zbqA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		3 TYR A  43
GLY A  12
PHE A  41
 None
GOL  A1386 (-4.7A)
None
 0.68A 2m2pB-4b6zA:
undetectable		 2m2pB-4b6zA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Triticum
aestivum) 		PF00160
(Pro_isomerase) 		3 TYR A  55
GLY A  57
PHE A  74
 None
 0.63A 2m2pB-4e1qA:
undetectable		 2m2pB-4e1qA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		3 TYR A 191
GLY A 185
PHE A 351
 None
 0.66A 2m2pB-4emyA:
undetectable		 2m2pB-4emyA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyv PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Serendipita
indica) 		PF00160
(Pro_isomerase) 		3 TYR A  48
GLY A  50
PHE A  67
 None
 0.71A 2m2pB-4eyvA:
undetectable		 2m2pB-4eyvA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fab IGG2A-KAPPA 4-4-20
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 180
GLY H 149
PHE H 151
 None
 0.71A 2m2pB-4fabH:
undetectable		 2m2pB-4fabH:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		3 TYR A 297
GLY A 285
PHE A 263
 None
 0.69A 2m2pB-4gyoA:
undetectable		 2m2pB-4gyoA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h20 HEAVY CHAIN OF FAB
FRAGMENT FROM THE
ANTI-RICIN
MONOCLONAL ANTIBODY
RAC18

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 181
GLY H 150
PHE H 152
 None
 0.72A 2m2pB-4h20H:
undetectable		 2m2pB-4h20H:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Triticum
aestivum) 		PF00160
(Pro_isomerase) 		3 TYR A  55
GLY A  57
PHE A  74
 None
 0.64A 2m2pB-4hy7A:
undetectable		 2m2pB-4hy7A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		3 TYR A 301
GLY A 289
PHE A 267
 None
 0.69A 2m2pB-4i1aA:
undetectable		 2m2pB-4i1aA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		3 TYR A 300
GLY A 288
PHE A 266
 None
 0.65A 2m2pB-4i9cA:
undetectable		 2m2pB-4i9cA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5a PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
F, MITOCHONDRIAL

(Homo sapiens) 		PF00160
(Pro_isomerase) 		3 TYR X  90
GLY X  92
PHE X 109
 None
 0.68A 2m2pB-4j5aX:
undetectable		 2m2pB-4j5aX:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Brugia malayi) 		PF00160
(Pro_isomerase) 		3 TYR A  55
GLY A  57
PHE A  74
 None
 0.60A 2m2pB-4jcpA:
undetectable		 2m2pB-4jcpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Citrus sinensis) 		PF00160
(Pro_isomerase) 		3 TYR A  55
GLY A  57
PHE A  74
 None
 0.64A 2m2pB-4jjmA:
undetectable		 2m2pB-4jjmA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kso CIRCADIAN CLOCK
PROTEIN KAIB

(Synechococcus
elongatus) 		no annotation 3 TYR C  39
GLY C  37
PHE C  35
 None
 0.68A 2m2pB-4ksoC:
undetectable		 2m2pB-4ksoC:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 3 TYR A 281
GLY A 349
PHE A 282
 None
 0.67A 2m2pB-4rggA:
undetectable		 2m2pB-4rggA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl3 CHITINASE A

(Pteris
ryukyuensis) 		PF00704
(Glyco_hydro_18) 		3 TYR A 310
GLY A 346
PHE A 307
 None
 0.71A 2m2pB-4rl3A:
undetectable		 2m2pB-4rl3A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		3 TYR A 552
GLY A 554
PHE A 136
 None
 0.53A 2m2pB-4uw2A:
undetectable		 2m2pB-4uw2A:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		3 TYR B  95
GLY B 131
PHE B 133
 None
 0.66A 2m2pB-4yjfB:
undetectable		 2m2pB-4yjfB:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		3 TYR B 297
GLY B 293
PHE B 262
 None
 0.71A 2m2pB-5a7vB:
undetectable		 2m2pB-5a7vB:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		3 TYR A 114
GLY A 116
PHE A 110
 None
 0.63A 2m2pB-5c6uA:
undetectable		 2m2pB-5c6uA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 TYR A 297
GLY A 334
PHE A 294
 TYR  A 297 ( 1.3A)
GLY  A 334 (-0.0A)
PHE  A 294 ( 1.3A)
 0.67A 2m2pB-5d7wA:
undetectable		 2m2pB-5d7wA:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		3 TYR A 493
GLY A 411
PHE A 413
 None
 0.71A 2m2pB-5dfmA:
undetectable		 2m2pB-5dfmA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doi TELOMERASE-ASSOCIATE
D PROTEIN 19

(Tetrahymena
thermophila) 		no annotation 3 TYR A 123
GLY A  41
PHE A  43
 None
 0.68A 2m2pB-5doiA:
undetectable		 2m2pB-5doiA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1r 7S VICILIN

(Carya
illinoinensis) 		PF00190
(Cupin_1) 		3 TYR A 764
GLY A 596
PHE A 598
 None
 0.39A 2m2pB-5e1rA:
undetectable		 2m2pB-5e1rA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyi NON-STRUCTURAL
PROTEIN 11

(Porcine
reproductive
and respiratory
syndrome virus) 		no annotation 3 TYR A  69
GLY A 106
PHE A  76
 PG0  A 303 (-4.2A)
None
None
 0.59A 2m2pB-5eyiA:
undetectable		 2m2pB-5eyiA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f17 NON-STRUCTURAL
PROTEIN 11

(Equine
arteritis virus) 		no annotation 3 TYR A  66
GLY A 103
PHE A  73
 None
 0.65A 2m2pB-5f17A:
undetectable		 2m2pB-5f17A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		3 TYR A  83
GLY A  94
PHE A  88
 None
 0.59A 2m2pB-5j6eA:
undetectable		 2m2pB-5j6eA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		3 TYR A 586
GLY A 513
PHE A 511
 None
 0.46A 2m2pB-5l9wA:
undetectable		 2m2pB-5l9wA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		3 TYR A 234
GLY A 213
PHE A 237
 None
 0.64A 2m2pB-5m60A:
undetectable		 2m2pB-5m60A:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		3 TYR A  89
GLY A  91
PHE A  52
 None
 0.70A 2m2pB-5mqmA:
undetectable		 2m2pB-5mqmA:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		3 TYR A1606
GLY A1608
PHE A1584
 None
 0.69A 2m2pB-5mznA:
undetectable		 2m2pB-5mznA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 TYR A 456
GLY A 454
PHE A 457
 None
 0.69A 2m2pB-5nz7A:
undetectable		 2m2pB-5nz7A:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		3 TYR A 531
GLY A 535
PHE A 533
 None
 0.68A 2m2pB-5te1A:
undetectable		 2m2pB-5te1A:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 TYR B 531
GLY B 535
PHE B 533
 None
 0.71A 2m2pB-5tetB:
undetectable		 2m2pB-5tetB:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yba PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trichomonas
vaginalis) 		no annotation 3 TYR A  56
GLY A  58
PHE A  75
 None
 0.60A 2m2pB-5ybaA:
undetectable		 2m2pB-5ybaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica) 		no annotation 3 TYR A  61
GLY A  30
PHE A  56
 None
 0.70A 2m2pB-5yhpA:
undetectable		 2m2pB-5yhpA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywo 2F2 HEAVY CHAIN

(Mus musculus) 		no annotation 3 TYR N 180
GLY N 149
PHE N 151
 None
 0.68A 2m2pB-5ywoN:
undetectable		 2m2pB-5ywoN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 3 TYR A  45
GLY A  15
PHE A  41
 None
 0.65A 2m2pB-6ap6A:
undetectable		 2m2pB-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 3 TYR A1218
GLY A1216
PHE A1214
 None
 0.65A 2m2pB-6apxA:
undetectable		 2m2pB-6apxA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7j 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Vibrio cholerae) 		no annotation 3 TYR A  26
GLY A  19
PHE A  22
 None
 0.71A 2m2pB-6b7jA:
undetectable		 2m2pB-6b7jA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 TYR A 127
GLY A 117
PHE A 115
 None
 0.66A 2m2pB-6bf6A:
undetectable		 2m2pB-6bf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 3 TYR A1271
GLY A 449
PHE A 451
 None
 0.71A 2m2pB-6fikA:
undetectable		 2m2pB-6fikA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 3 TYR A1039
GLY A1046
PHE A1048
 None
 0.52A 2m2pB-6fj4A:
undetectable		 2m2pB-6fj4A:
undetectable