SIMILAR PATTERNS OF AMINO ACIDS FOR 2M2O_B_DHIB24_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjx PROTEIN DISULFIDE
ISOMERASE

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		4 GLY A 142
PHE A 155
LYS A 119
THR A 121
 None
 1.01A 2m2oB-1bjxA:
undetectable		 2m2oB-1bjxA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)

(Rattus
norvegicus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 ARG A 164
GLY A 125
PRO A  31
THR A  36
 None
 1.12A 2m2oB-1bu8A:
undetectable		 2m2oB-1bu8A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwv INVASIN

(Yersinia
pseudotuberculosis) 		PF02369
(Big_1)
PF07979
(Intimin_C)
PF09134
(Invasin_D3) 		4 ARG A 926
GLY A 934
LYS A 816
THR A 817
 None
 1.11A 2m2oB-1cwvA:
undetectable		 2m2oB-1cwvA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwv INVASIN

(Yersinia
pseudotuberculosis) 		PF02369
(Big_1)
PF07979
(Intimin_C)
PF09134
(Invasin_D3) 		4 ARG A 926
PRO A 815
LYS A 816
THR A 817
 None
 1.24A 2m2oB-1cwvA:
undetectable		 2m2oB-1cwvA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czv PROTEIN (COAGULATION
FACTOR V)

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 GLY A 115
PRO A 140
LYS A 141
THR A 142
 None
 0.96A 2m2oB-1czvA:
undetectable		 2m2oB-1czvA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		4 GLY A 121
PRO A 191
LYS A 192
THR A 193
 None
 1.32A 2m2oB-1f6yA:
undetectable		 2m2oB-1f6yA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 ARG A 164
GLY A 125
PRO A  31
THR A  36
 None
 1.15A 2m2oB-1hplA:
undetectable		 2m2oB-1hplA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		4 ARG A 243
GLY A 219
LYS A 181
THR A 182
 DGS  A 492 (-3.1A)
None
None
NA  A  11 (-3.5A)
 1.32A 2m2oB-1ktwA:
undetectable		 2m2oB-1ktwA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ARG A  99
PHE A  71
PRO A  70
THR A  74
 None
 1.17A 2m2oB-1lrwA:
undetectable		 2m2oB-1lrwA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhm S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Solanum
tuberosum) 		PF01536
(SAM_decarbox) 		4 GLY A 265
PRO A 268
LYS A 269
THR A 270
 None
 1.37A 2m2oB-1mhmA:
undetectable		 2m2oB-1mhmA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 GLY B2139
PRO B2164
LYS B2165
THR B2166
 None
 0.70A 2m2oB-1sddB:
undetectable		 2m2oB-1sddB:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		4 ARG A 426
GLY A 408
PHE A 469
THR A 466
 None
 1.35A 2m2oB-1v02A:
undetectable		 2m2oB-1v02A:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ARG A 211
GLY A 215
LYS A 237
THR A 238
 None
 1.31A 2m2oB-1w1kA:
undetectable		 2m2oB-1w1kA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 GLY A 252
PHE A 235
LYS A 207
THR A 206
 None
 1.19A 2m2oB-1xp4A:
undetectable		 2m2oB-1xp4A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF01420
(Methylase_S) 		4 GLY A 242
PHE A 320
PRO A 263
THR A 304
 None
 1.10A 2m2oB-1yf2A:
undetectable		 2m2oB-1yf2A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 ARG A  12
GLY A   9
PHE A   8
PRO A   6
 None
 1.23A 2m2oB-1ygpA:
undetectable		 2m2oB-1ygpA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1f THREONINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 ARG A 169
GLY A  72
LYS A 174
THR A 175
 None
 1.14A 2m2oB-2d1fA:
undetectable		 2m2oB-2d1fA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		4 ARG A 106
GLY A 103
PRO A 192
THR A 190
 None
None
None
NO3  A 700 (-3.9A)
 1.37A 2m2oB-2g29A:
undetectable		 2m2oB-2g29A:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 ARG A  63
GLY A 551
PRO A  53
THR A 491
 None
 1.01A 2m2oB-2h4tA:
undetectable		 2m2oB-2h4tA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 GLY A 223
PRO A 258
LYS A 257
THR A 249
 None
 1.37A 2m2oB-2iukA:
undetectable		 2m2oB-2iukA:
4.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		4 GLY A 149
PRO A  18
LYS A  14
THR A  16
 None
 1.26A 2m2oB-2jssA:
undetectable		 2m2oB-2jssA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 GLY B 153
PHE B 236
LYS B  29
THR B  30
 None
HEC  B 250 ( 4.9A)
None
None
 1.35A 2m2oB-2jxmB:
undetectable		 2m2oB-2jxmB:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ope PILX

(Neisseria
meningitidis) 		PF11530
(Pilin_PilX) 		4 GLY A 109
PRO A 104
LYS A 105
THR A 106
 None
 1.13A 2m2oB-2opeA:
undetectable		 2m2oB-2opeA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		4 ARG A 289
GLY A 216
PHE A 247
PRO A 219
 None
 1.37A 2m2oB-2ozeA:
undetectable		 2m2oB-2ozeA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens) 		PF00144
(Beta-lactamase) 		4 GLY A 116
PHE A 142
PRO A 144
THR A 113
 None
 1.13A 2m2oB-2qz6A:
undetectable		 2m2oB-2qz6A:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ARG A 388
GLY A 384
PHE A 382
THR A 554
 None
 1.31A 2m2oB-2x7jA:
undetectable		 2m2oB-2x7jA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsj THREONINE SYNTHASE

(Aquifex
aeolicus) 		PF00291
(PALP) 		4 ARG A 162
GLY A  66
LYS A 167
THR A 168
 None
 1.24A 2m2oB-2zsjA:
undetectable		 2m2oB-2zsjA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 ARG A 332
GLY A 329
PRO A 291
THR A 202
 None
 1.29A 2m2oB-3a14A:
undetectable		 2m2oB-3a14A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 GLY A 221
PRO A 259
LYS A 260
THR A 261
 None
 1.31A 2m2oB-3axxA:
undetectable		 2m2oB-3axxA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkh LYTIC
TRANSGLYCOSYLASE

(Pseudomonas
virus phiKZ) 		PF01464
(SLT)
PF01471
(PG_binding_1) 		4 PHE A 234
PRO A 241
LYS A 242
THR A 243
 None
 1.21A 2m2oB-3bkhA:
undetectable		 2m2oB-3bkhA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn6 LACTADHERIN

(Bos taurus) 		PF00754
(F5_F8_type_C) 		4 ARG A 136
GLY A  65
PRO A  13
THR A  11
 None
 1.23A 2m2oB-3bn6A:
undetectable		 2m2oB-3bn6A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ARG A 300
GLY A 323
PRO A 326
THR A 368
 None
 1.28A 2m2oB-3ckzA:
undetectable		 2m2oB-3ckzA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		4 GLY B 149
PRO B  48
LYS B  47
THR B  46
 None
 1.28A 2m2oB-3egwB:
undetectable		 2m2oB-3egwB:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		4 GLY A 285
PHE A 284
PRO A 277
THR A 282
 None
 1.27A 2m2oB-3emyA:
undetectable		 2m2oB-3emyA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		4 GLY A 482
PHE A 483
LYS A  17
THR A  16
 None
None
PGR  A 716 ( 4.7A)
None
 1.34A 2m2oB-3eo7A:
undetectable		 2m2oB-3eo7A:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLY A 431
PHE A 494
PRO A 496
LYS A 497
 None
 1.06A 2m2oB-3gdeA:
undetectable		 2m2oB-3gdeA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE

(Deinococcus
radiodurans) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 ARG A 244
PHE A 264
PRO A 260
THR A 258
 FAD  A 450 ( 3.9A)
None
None
None
 1.25A 2m2oB-3hdyA:
undetectable		 2m2oB-3hdyA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j93 NEUTRALIZING
ANTIBODY 22A12,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H 119
PRO H  12
LYS H  11
THR H 116
 None
 1.23A 2m2oB-3j93H:
undetectable		 2m2oB-3j93H:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		4 ARG A  66
PHE A  98
PRO A  97
THR A  94
 None
 1.00A 2m2oB-3jxzA:
undetectable		 2m2oB-3jxzA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		4 GLY A4116
PRO A4134
LYS A4135
THR A4114
 None
 1.16A 2m2oB-3kciA:
undetectable		 2m2oB-3kciA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13377
(Peripla_BP_3) 		4 ARG A 195
GLY A 164
PRO A 297
THR A 327
 ACT  A   1 (-2.7A)
None
None
None
 1.21A 2m2oB-3kkeA:
undetectable		 2m2oB-3kkeA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN

(Rhodopseudomonas
palustris) 		PF02743
(dCache_1) 		4 ARG A 216
GLY A 155
PHE A 167
THR A 187
 None
None
None
MPD  A   1 ( 4.6A)
 1.28A 2m2oB-3lifA:
undetectable		 2m2oB-3lifA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		4 ARG A 452
GLY A 451
PRO A 436
THR A 434
 CL  A  23 ( 3.1A)
None
None
None
 1.29A 2m2oB-3m1uA:
undetectable		 2m2oB-3m1uA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		4 GLY A  53
PRO A 345
LYS A  75
THR A  74
 None
None
ACT  A 399 ( 4.6A)
ACT  A 399 (-4.3A)
 1.31A 2m2oB-3m8yA:
undetectable		 2m2oB-3m8yA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtv PAPAIN-LIKE CYSTEINE
PROTEASE

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05411
(Peptidase_C32) 		4 GLY A 170
PHE A 150
PRO A  86
THR A  84
 None
 1.17A 2m2oB-3mtvA:
undetectable		 2m2oB-3mtvA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		4 ARG A 218
GLY A 191
LYS A 155
THR A 157
 None
None
KCX  A 154 ( 3.5A)
None
 1.01A 2m2oB-3pnzA:
undetectable		 2m2oB-3pnzA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r50 IPOMOELIN

(Ipomoea batatas) 		PF01419
(Jacalin) 		4 GLY A 116
PHE A  39
PRO A  43
THR A  46
 None
 1.25A 2m2oB-3r50A:
undetectable		 2m2oB-3r50A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rdv CAP-GLY
DOMAIN-CONTAINING
LINKER PROTEIN 1

(Homo sapiens) 		PF01302
(CAP_GLY) 		4 ARG A 107
GLY A 101
PRO A 113
LYS A 115
 None
 1.19A 2m2oB-3rdvA:
undetectable		 2m2oB-3rdvA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th1 CHLOROCATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ARG A 246
GLY A 197
PHE A 198
PRO A 200
 None
 1.08A 2m2oB-3th1A:
undetectable		 2m2oB-3th1A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		4 ARG A  42
GLY A 232
PHE A  43
THR A 236
 None
 1.01A 2m2oB-3ue9A:
undetectable		 2m2oB-3ue9A:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLY A 249
PRO A 175
LYS A 377
THR A 379
 None
 1.27A 2m2oB-3ve2A:
undetectable		 2m2oB-3ve2A:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLY A1743
PHE A1754
PRO A1757
THR A1740
 None
 1.35A 2m2oB-3vkgA:
undetectable		 2m2oB-3vkgA:
1.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 GLY A 221
PRO A 259
LYS A 260
THR A 261
 None
GOL  A 501 (-4.1A)
None
None
 1.08A 2m2oB-3w6mA:
undetectable		 2m2oB-3w6mA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 291
GLY A 231
PHE A 229
PRO A 604
 None
 1.00A 2m2oB-3zz1A:
undetectable		 2m2oB-3zz1A:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A  86
GLY A  98
PRO A 728
THR A 726
 None
 1.02A 2m2oB-4aipA:
undetectable		 2m2oB-4aipA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		4 ARG A 123
PRO A 191
LYS A 190
THR A 164
 None
 1.35A 2m2oB-4bs9A:
undetectable		 2m2oB-4bs9A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 GLY V1386
PHE V1359
PRO V1411
THR V1413
 None
 1.21A 2m2oB-4bxsV:
undetectable		 2m2oB-4bxsV:
2.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq8 ACETATE KINASE

(Mycobacterium
marinum) 		PF00871
(Acetate_kinase) 		4 ARG A 328
GLY A 321
PRO A 370
THR A 371
 None
 1.26A 2m2oB-4dq8A:
undetectable		 2m2oB-4dq8A:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 GLY A 320
PRO A 136
LYS A 137
THR A 138
 None
 1.27A 2m2oB-4dvjA:
undetectable		 2m2oB-4dvjA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fze N26_I1 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  50
PHE H  33
PRO H  52
THR H  56
 None
 1.03A 2m2oB-4fzeH:
undetectable		 2m2oB-4fzeH:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		4 ARG A 164
GLY A 105
PRO A 185
THR A 183
 None
 0.92A 2m2oB-4h0pA:
undetectable		 2m2oB-4h0pA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfo BIOGENIC
AMINE-BINDING
PROTEIN

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		4 GLY A  38
PRO A  64
LYS A  67
THR A  68
 None
 0.95A 2m2oB-4hfoA:
undetectable		 2m2oB-4hfoA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		4 GLY A 430
PHE A  47
LYS A 111
THR A 112
 None
 1.31A 2m2oB-4hz8A:
undetectable		 2m2oB-4hz8A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		4 GLY A 579
PRO A 513
LYS A 514
THR A 515
 None
 1.21A 2m2oB-4issA:
undetectable		 2m2oB-4issA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 GLY A 518
PRO A 513
LYS A 269
THR A 268
 None
 1.20A 2m2oB-4ka8A:
undetectable		 2m2oB-4ka8A:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43

(Thermotoga
petrophila) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 ARG A 337
GLY A 336
PHE A 304
THR A 301
 None
 1.30A 2m2oB-4kc8A:
undetectable		 2m2oB-4kc8A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ARG A 291
GLY A 292
PHE A 293
PRO A 295
 None
 1.32A 2m2oB-4my0A:
undetectable		 2m2oB-4my0A:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqq CADHERIN-3

(Mus musculus) 		PF00028
(Cadherin) 		4 GLY A 144
PRO A 106
LYS A 107
THR A 133
 CA  A 303 ( 4.7A)
None
None
None
 1.24A 2m2oB-4nqqA:
undetectable		 2m2oB-4nqqA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 GLY A 156
PRO A 180
LYS A 181
THR A 182
 None
 1.03A 2m2oB-4o9xA:
undetectable		 2m2oB-4o9xA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohs FAR-RED FLUORESCENT
PROTEIN AQ143

(Actinia equina) 		PF01353
(GFP) 		4 ARG A 181
GLY A  87
LYS A  67
THR A  68
 None
None
CH6  A  63 ( 4.0A)
None
 1.10A 2m2oB-4ohsA:
undetectable		 2m2oB-4ohsA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or5 PROTEIN TAT
AF4/FMR2 FAMILY
MEMBER 4

(Human
immunodeficiency
virus 1;
Homo sapiens) 		PF00539
(Tat)
PF05110
(AF-4) 		4 GLY E  67
PRO C  18
LYS C  19
THR C  20
 None
 1.03A 2m2oB-4or5E:
undetectable		 2m2oB-4or5E:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		4 ARG A 292
GLY A 240
LYS A 243
THR A 244
 None
 1.36A 2m2oB-4orbA:
undetectable		 2m2oB-4orbA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 ARG A 221
GLY A 480
PHE A 476
THR A 483
 None
 1.30A 2m2oB-4qwwA:
undetectable		 2m2oB-4qwwA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv7 DIADENYLATE CYCLASE

(Listeria
monocytogenes) 		PF02457
(DisA_N) 		4 ARG A 103
PHE A  63
PRO A  65
THR A  67
 ATP  A1001 (-3.5A)
None
None
None
 1.35A 2m2oB-4rv7A:
undetectable		 2m2oB-4rv7A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA

(Homo sapiens;
Escherichia
virus T4) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		4 GLY A 145
PRO A 205
LYS A 206
THR A 207
 None
ATP  A1201 ( 4.5A)
None
None
 1.31A 2m2oB-4wtvA:
undetectable		 2m2oB-4wtvA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhb IRON-CHELATOR
UTILIZATION PROTEIN

(Thermobifida
fusca) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		4 ARG A  87
GLY A 113
PHE A  58
PRO A  61
 FAD  A 301 (-3.8A)
FAD  A 301 (-3.6A)
None
None
 0.90A 2m2oB-4yhbA:
undetectable		 2m2oB-4yhbA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrx F5/8 TYPE C DOMAIN
PROTEIN

(Bacteroides
ovatus) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		4 ARG A 496
GLY A 600
PRO A 566
THR A 568
 None
 1.26A 2m2oB-4zrxA:
undetectable		 2m2oB-4zrxA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 GLY A 149
PRO A 177
LYS A 176
THR A 175
 None
 1.37A 2m2oB-5bxpA:
undetectable		 2m2oB-5bxpA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fie CELL SURFACE PROTEIN
SPAA

(Lactobacillus
rhamnosus) 		no annotation 4 GLY A  67
PRO A  72
LYS A  47
THR A  46
 None
 1.15A 2m2oB-5fieA:
undetectable		 2m2oB-5fieA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 337
GLY A 276
PHE A 274
PRO A 755
 None
 1.02A 2m2oB-5fjiA:
undetectable		 2m2oB-5fjiA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghf AMINOTRANSFERASE
CLASS-III

(Ochrobactrum
anthropi) 		PF00202
(Aminotran_3) 		4 ARG A 202
PRO A 237
LYS A 238
THR A 239
 None
 1.26A 2m2oB-5ghfA:
undetectable		 2m2oB-5ghfA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		4 ARG A 627
GLY A 636
PRO A 691
LYS A 692
 None
 1.23A 2m2oB-5gkqA:
undetectable		 2m2oB-5gkqA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdl CELL SURFACE PROTEIN
SPAA

(Lactobacillus
rhamnosus) 		no annotation 4 GLY A  67
PRO A  72
LYS A  47
THR A  46
 None
 1.04A 2m2oB-5hdlA:
undetectable		 2m2oB-5hdlA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 GLY A 898
PRO A 942
LYS A 943
THR A 944
 None
 0.89A 2m2oB-5hzvA:
undetectable		 2m2oB-5hzvA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4a ARGONAUTE PROTEIN

(Marinitoga
piezophila) 		no annotation 4 GLY A 233
PRO A 238
LYS A 239
THR A 240
 None
 1.24A 2m2oB-5i4aA:
undetectable		 2m2oB-5i4aA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 579
PRO A 513
LYS A 514
THR A 515
 None
 1.21A 2m2oB-5i8iA:
undetectable		 2m2oB-5i8iA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		4 GLY A 140
PHE A 368
PRO A 180
THR A 178
 None
 1.27A 2m2oB-5i92A:
undetectable		 2m2oB-5i92A:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 333
GLY A 272
PHE A 270
PRO A 747
 None
 1.00A 2m2oB-5ju6A:
undetectable		 2m2oB-5ju6A:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00831
(Ribosomal_L29) 		4 ARG Z 109
GLY Z 106
PRO Z 102
LYS Z 101
 A  A  59 ( 3.0A)
None
A  A  94 ( 3.7A)
None
 1.22A 2m2oB-5mlcZ:
undetectable		 2m2oB-5mlcZ:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 ARG A 332
GLY A 271
PHE A 269
PRO A 752
 None
 1.02A 2m2oB-5nbsA:
undetectable		 2m2oB-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5the UNCHARACTERIZED
PROTEIN

(Vanderwaltozyma
polyspora) 		no annotation 4 GLY A 832
PHE A 831
PRO A 871
THR A 869
 None
 1.19A 2m2oB-5theA:
undetectable		 2m2oB-5theA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2i NUCLEOSIDE
DIPHOSPHATE KINASE

(Naegleria
fowleri) 		PF00334
(NDK) 		4 GLY A 112
PRO A  95
LYS A  94
THR A  93
 None
 1.02A 2m2oB-5u2iA:
undetectable		 2m2oB-5u2iA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9c DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Yersinia
enterocolitica) 		PF04321
(RmlD_sub_bind) 		4 GLY A  95
PRO A  54
LYS A  53
THR A  50
 None
 1.37A 2m2oB-5u9cA:
undetectable		 2m2oB-5u9cA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7q 50S RIBOSOMAL
PROTEIN L4

(Mycobacterium
tuberculosis) 		PF00573
(Ribosomal_L4) 		4 ARG E  52
GLY E  54
PRO E  99
LYS E 100
 C  A 533 ( 3.6A)
None
G  A1379 ( 4.0A)
G  A 798 ( 2.6A)
 1.31A 2m2oB-5v7qE:
undetectable		 2m2oB-5v7qE:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00573
(Ribosomal_L4) 		4 PHE E 182
PRO E 185
LYS E 186
THR E 187
 None
None
None
C  A 329 ( 3.4A)
 1.22A 2m2oB-5x8tE:
undetectable		 2m2oB-5x8tE:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 439
PRO A 176
LYS A 175
THR A 174
 CA  A 701 ( 4.6A)
None
None
None
 1.31A 2m2oB-5xfmA:
undetectable		 2m2oB-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0k IOTA-CARRAGEENAN
SULFATASE

(Pseudoalteromonas) 		no annotation 4 ARG A 254
GLY A 299
PRO A 232
THR A 234
 None
None
None
9RN  A 502 ( 3.3A)
 1.06A 2m2oB-6b0kA:
undetectable		 2m2oB-6b0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3o SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2) 		4 GLY A1157
PHE A1155
PRO A1141
LYS A1142
 None
 1.29A 2m2oB-6b3oA:
undetectable		 2m2oB-6b3oA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 4 ARG A 196
GLY A 203
PHE A 202
PRO A 217
 RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
None
None
 1.33A 2m2oB-6c7sA:
undetectable		 2m2oB-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 4 GLY A 183
PRO A 346
LYS A 345
THR A 180
 None
 1.27A 2m2oB-6cj7A:
undetectable		 2m2oB-6cj7A:
undetectable