SIMILAR PATTERNS OF AMINO ACIDS FOR 2LH8_A_VIBA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		4 PRO A 171
HIS A 123
ASP A 126
TYR A 131
 None
 1.07A 2lh8A-1edgA:
0.0		 2lh8A-1edgA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 4 PRO B 326
MET B 324
HIS B 307
ASP B 455
 None
 1.44A 2lh8A-1ej6B:
1.5		 2lh8A-1ej6B:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE

(Clarkia breweri) 		PF03492
(Methyltransf_7) 		4 PRO X 257
MET X 150
HIS X 188
ASP X 187
 None
SAL  X2000 ( 4.8A)
None
None
 1.43A 2lh8A-1m6eX:
0.0		 2lh8A-1m6eX:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 PRO A 215
HIS A 212
ASP A 240
TYR A 213
 None
None
IFG  A 557 ( 4.7A)
None
 1.38A 2lh8A-1nowA:
0.0		 2lh8A-1nowA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		4 PRO A 320
MET A 318
HIS A 322
TYR A 321
 None
 1.43A 2lh8A-1qdmA:
0.0		 2lh8A-1qdmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 PRO A 285
ASP A 527
ASP A 168
TYR A 169
 None
 1.45A 2lh8A-1r8wA:
0.0		 2lh8A-1r8wA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v1p EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 HIS A  29
ASP A  24
ASP A  27
TYR A  31
 None
 1.15A 2lh8A-1v1pA:
0.0		 2lh8A-1v1pA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		4 PRO A 224
HIS A 228
ASP A 190
ASP A 229
 None
None
CA  A 417 (-2.4A)
CA  A 417 (-3.5A)
 1.32A 2lh8A-1vblA:
0.0		 2lh8A-1vblA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh2 S-RIBOSYLHOMOCYSTEIN
ASE

(Deinococcus
radiodurans) 		PF02664
(LuxS) 		4 PRO A 118
HIS A  57
ASP A  52
ASP A 132
 None
ZN  A 167 (-3.4A)
None
None
 1.20A 2lh8A-1vh2A:
0.0		 2lh8A-1vh2A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 HIS A 114
ASP A  35
ASP A 113
TYR A 161
 None
 1.28A 2lh8A-1z1wA:
undetectable		 2lh8A-1z1wA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 PRO A 209
ASP A 215
ASP A 214
TYR A 293
 None
 1.30A 2lh8A-2d1gA:
undetectable		 2lh8A-2d1gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PRO A 289
HIS A 295
ASP A 297
TYR A 293
 None
 1.36A 2lh8A-2e6kA:
undetectable		 2lh8A-2e6kA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eql HORSE MILK LYSOZYME

(Equus caballus) 		PF00062
(Lys) 		4 MET A  31
HIS A 114
ASP A 117
TYR A 123
 None
 1.04A 2lh8A-2eqlA:
undetectable		 2lh8A-2eqlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 PRO A 182
HIS A 179
ASP A 207
TYR A 180
 None
 1.41A 2lh8A-2gjxA:
undetectable		 2lh8A-2gjxA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B

(Homo sapiens) 		no annotation 4 PRO M 215
HIS M 212
ASP M 240
TYR M 213
 None
 1.39A 2lh8A-2gk1M:
undetectable		 2lh8A-2gk1M:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		4 PRO A 218
HIS A 216
ASP A 225
TYR A 223
 None
 1.42A 2lh8A-2gsnA:
undetectable		 2lh8A-2gsnA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 PRO A 328
MET A 329
ASP A 340
TYR A 227
 None
 1.38A 2lh8A-2gwcA:
undetectable		 2lh8A-2gwcA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i15 HYPOTHETICAL PROTEIN
MG296 HOMOLOG

(Mycoplasma
pneumoniae) 		PF09644
(Mg296) 		4 MET A  57
ASP A  45
ASP A  44
TYR A  42
 None
 1.20A 2lh8A-2i15A:
undetectable		 2lh8A-2i15A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7h NITROREDUCTASE-LIKE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		4 PRO A  41
HIS A  43
ASP A 100
ASP A 109
 None
 0.98A 2lh8A-2i7hA:
undetectable		 2lh8A-2i7hA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		4 PRO A  80
HIS A  33
ASP A  72
TYR A  67
 None
 1.44A 2lh8A-2o3iA:
undetectable		 2lh8A-2o3iA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 366
ASP A 215
ASP A 167
TYR A 166
 None
 1.42A 2lh8A-2o56A:
1.0		 2lh8A-2o56A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		4 PRO A 117
HIS A 139
ASP A 148
ASP A 146
 None
 1.40A 2lh8A-2ogaA:
undetectable		 2lh8A-2ogaA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pet LUTHERAN BLOOD GROUP
GLYCOPROTEIN

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 PRO A  24
HIS A  28
ASP A  29
TYR A  31
 None
 1.45A 2lh8A-2petA:
undetectable		 2lh8A-2petA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		4 PRO A 266
HIS A 263
ASP A 289
TYR A 265
 None
ZN  A 377 (-3.1A)
None
None
 1.46A 2lh8A-2qpxA:
undetectable		 2lh8A-2qpxA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 PRO A  96
HIS A 121
ASP A 271
TYR A 126
 None
 1.34A 2lh8A-2vgiA:
undetectable		 2lh8A-2vgiA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl3 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus sp.
DK17) 		PF00903
(Glyoxalase) 		4 PRO A 135
MET A 136
ASP A 221
TYR A 225
 None
 1.44A 2lh8A-2wl3A:
undetectable		 2lh8A-2wl3A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		4 PRO A 166
HIS A 170
ASP A 175
TYR A 199
 None
 1.39A 2lh8A-2zbzA:
0.6		 2lh8A-2zbzA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy 14-3-3-LIKE PROTEIN
GF14-C

(Oryza sativa) 		PF00244
(14-3-3) 		4 MET C 125
HIS C 130
ASP C  99
TYR C 132
 None
 1.47A 2lh8A-3axyC:
undetectable		 2lh8A-3axyC:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		4 MET A 210
HIS A 214
ASP A 222
TYR A 250
 None
 1.42A 2lh8A-3b59A:
undetectable		 2lh8A-3b59A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcw UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF05899
(Cupin_3) 		4 PRO A  99
MET A  98
HIS A  88
ASP A  94
 None
ACT  A 123 ( 4.1A)
None
None
 1.20A 2lh8A-3bcwA:
undetectable		 2lh8A-3bcwA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 PRO A 236
HIS A 234
ASP A 183
TYR A 192
 GOL  A 706 (-4.4A)
G6D  A 693 ( 3.8A)
None
None
 1.46A 2lh8A-3bmwA:
undetectable		 2lh8A-3bmwA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 PRO A 236
HIS A 234
ASP A 189
TYR A 192
 GOL  A 706 (-4.4A)
G6D  A 693 ( 3.8A)
None
None
 1.46A 2lh8A-3bmwA:
undetectable		 2lh8A-3bmwA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6s ALLERGEN DER F I

(Dermatophagoides
farinae) 		PF00112
(Peptidase_C1) 		4 PRO A  12
ASP A 184
ASP A 185
TYR A 178
 None
 1.39A 2lh8A-3d6sA:
undetectable		 2lh8A-3d6sA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA

(Pseudomonas
aeruginosa) 		PF05141
(DIT1_PvcA) 		4 PRO A 258
HIS A 255
ASP A 273
ASP A 274
 None
PO4  A 329 (-4.0A)
None
None
 1.25A 2lh8A-3e59A:
0.7		 2lh8A-3e59A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7q INTEGRIN BETA-4

(Homo sapiens) 		PF00041
(fn3) 		4 PRO A1154
MET A1155
ASP A1175
TYR A1157
 None
 1.10A 2lh8A-3f7qA:
undetectable		 2lh8A-3f7qA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		4 PRO A 521
HIS A 495
ASP A 611
TYR A 498
 None
 1.18A 2lh8A-3floA:
undetectable		 2lh8A-3floA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		4 PRO A 163
HIS A 161
ASP A 243
ASP A 242
 None
NP6  A 341 (-3.6A)
NP6  A 341 ( 4.6A)
None
 1.35A 2lh8A-3gs6A:
undetectable		 2lh8A-3gs6A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9j MCCB PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		4 PRO A 204
HIS A 201
ASP A 196
ASP A 199
 None
 1.39A 2lh8A-3h9jA:
undetectable		 2lh8A-3h9jA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		4 MET A1140
HIS A  13
ASP A  30
TYR A  75
 None
 1.37A 2lh8A-3jroA:
undetectable		 2lh8A-3jroA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmh D-LYXOSE ISOMERASE

(Escherichia
coli) 		PF07385
(Lyx_isomer) 		4 PRO A 101
MET A 102
HIS A 198
ASP A 196
 None
 1.46A 2lh8A-3kmhA:
undetectable		 2lh8A-3kmhA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3f PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		4 PRO X 424
MET X 425
ASP X 429
TYR X 427
 None
 1.31A 2lh8A-3l3fX:
undetectable		 2lh8A-3l3fX:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhi PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Neisseria
gonorrhoeae) 		PF01182
(Glucosamine_iso) 		4 PRO A 100
MET A 101
ASP A 114
TYR A 119
 None
 1.40A 2lh8A-3lhiA:
undetectable		 2lh8A-3lhiA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnp AMIDOHYDROLASE
FAMILY PROTEIN
OLEI01672_1_465

(Oleispira
antarctica) 		PF01979
(Amidohydro_1) 		4 PRO A 172
HIS A 216
ASP A 175
TYR A 187
 None
 1.40A 2lh8A-3lnpA:
undetectable		 2lh8A-3lnpA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 PRO A 218
MET A 220
ASP A 251
TYR A 250
 None
 1.42A 2lh8A-3lx6A:
undetectable		 2lh8A-3lx6A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PRO A 103
ASP A  87
ASP A  88
TYR A  74
 None
 1.33A 2lh8A-3m49A:
undetectable		 2lh8A-3m49A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 PRO A 218
MET A 220
ASP A 251
TYR A 250
 None
 1.45A 2lh8A-3me5A:
undetectable		 2lh8A-3me5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqo TRANSCRIPTIONAL
REGULATOR, LUXR
FAMILY

(Burkholderia
thailandensis) 		PF13426
(PAS_9) 		4 PRO A  67
MET A  69
ASP A  78
ASP A  77
 None
 1.06A 2lh8A-3mqoA:
undetectable		 2lh8A-3mqoA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PRO A  27
HIS A  32
ASP A 148
ASP A  82
 None
 1.26A 2lh8A-3mruA:
undetectable		 2lh8A-3mruA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8e MEMBRANE COFACTOR
PROTEIN

(Homo sapiens) 		PF00084
(Sushi) 		4 PRO B   4
ASP B  58
ASP B  57
TYR B  28
 None
 1.22A 2lh8A-3o8eB:
undetectable		 2lh8A-3o8eB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 PRO A 146
MET A 145
HIS A 111
ASP A 155
 None
 1.39A 2lh8A-3qtyA:
undetectable		 2lh8A-3qtyA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 PRO A 150
MET A 149
HIS A 147
ASP A 175
 None
 1.12A 2lh8A-3rcnA:
undetectable		 2lh8A-3rcnA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		4 PRO A 467
HIS A 346
ASP A 348
TYR A 350
 None
 1.40A 2lh8A-3rm5A:
undetectable		 2lh8A-3rm5A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 PRO A 403
HIS A 392
ASP A 371
TYR A 407
 None
 1.43A 2lh8A-3vssA:
undetectable		 2lh8A-3vssA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 HIS A 360
ASP A 355
ASP A 356
TYR A 352
 None
 1.19A 2lh8A-4a5qA:
undetectable		 2lh8A-4a5qA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Drosophila
melanogaster) 		PF01652
(IF4E) 		4 PRO A 114
HIS A 111
ASP A 104
TYR A 109
 None
 1.31A 2lh8A-4axgA:
undetectable		 2lh8A-4axgA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PRO R 221
MET R 220
ASP R 172
ASP R 195
 None
 1.33A 2lh8A-4bv4R:
undetectable		 2lh8A-4bv4R:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 PRO A1504
HIS A1577
ASP A1569
TYR A1558
 KCX  A1556 ( 4.1A)
None
None
KCX  A1556 ( 3.6A)
 1.40A 2lh8A-4c6oA:
undetectable		 2lh8A-4c6oA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF01421
(Reprolysin) 		4 MET A 332
HIS A 232
ASP A 234
TYR A 237
 None
 1.34A 2lh8A-4dd8A:
undetectable		 2lh8A-4dd8A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3w ACID PHOSPHATASE

(Francisella
tularensis) 		PF00328
(His_Phos_2) 		4 PRO A 310
MET A 312
ASP A 321
TYR A 326
 None
 1.42A 2lh8A-4e3wA:
undetectable		 2lh8A-4e3wA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		4 PRO A 165
HIS A  79
ASP A  87
ASP A  86
 None
UNL  A 303 ( 4.1A)
None
UNX  A 302 ( 2.6A)
 1.40A 2lh8A-4fp4A:
undetectable		 2lh8A-4fp4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		4 PRO A  30
HIS A  55
ASP A 197
TYR A  60
 None
 1.26A 2lh8A-4hyvA:
undetectable		 2lh8A-4hyvA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PRO A 221
MET A 220
ASP A 172
ASP A 195
 None
 1.38A 2lh8A-4lxrA:
undetectable		 2lh8A-4lxrA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhu ECTOINE HYDROXYLASE

(Sphingopyxis
alaskensis) 		PF05721
(PhyH) 		4 PRO A 229
MET A 179
HIS A 245
TYR A  46
 None
None
FE  A 401 (-3.9A)
None
 1.44A 2lh8A-4mhuA:
undetectable		 2lh8A-4mhuA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PRO A 429
ASP A 506
ASP A 504
TYR A 503
 None
 1.41A 2lh8A-4mycA:
1.9		 2lh8A-4mycA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		4 PRO A 283
MET A 249
ASP A 255
ASP A 286
 None
None
GOL  A 511 ( 2.9A)
GOL  A 510 ( 4.6A)
 1.32A 2lh8A-4nxkA:
undetectable		 2lh8A-4nxkA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbc D-AMINO ACID
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01063
(Aminotran_4) 		4 PRO A  54
HIS A  62
ASP A  59
TYR A  56
 None
 1.40A 2lh8A-4pbcA:
undetectable		 2lh8A-4pbcA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per ANGIOGENIN

(Gallus gallus) 		PF00074
(RnaseA) 		4 PRO B 109
HIS B  12
ASP B   7
TYR B   5
 None
 1.36A 2lh8A-4perB:
undetectable		 2lh8A-4perB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q58 INTEGRIN BETA-4

(Homo sapiens) 		PF00041
(fn3) 		4 PRO C1154
MET C1155
ASP C1175
TYR C1157
 None
 1.31A 2lh8A-4q58C:
undetectable		 2lh8A-4q58C:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 144
ASP A 218
ASP A 217
TYR A 181
 None
 1.31A 2lh8A-4redA:
undetectable		 2lh8A-4redA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tko EMRA

(Aquifex
aeolicus) 		PF13437
(HlyD_3)
PF13533
(Biotin_lipoyl_2) 		4 PRO B 277
ASP B  61
ASP B  64
TYR B  65
 None
 1.47A 2lh8A-4tkoB:
3.2		 2lh8A-4tkoB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 4 PRO A 107
HIS A 100
ASP A  84
TYR A  83
 None
 1.15A 2lh8A-4v30A:
undetectable		 2lh8A-4v30A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 PRO A  53
HIS A  78
ASP A 228
TYR A  83
 None
 1.08A 2lh8A-4yj5A:
undetectable		 2lh8A-4yj5A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 MET C 172
ASP C 246
ASP C 247
TYR C 165
 None
 1.47A 2lh8A-5aa5C:
2.0		 2lh8A-5aa5C:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff RIBOSOMAL PROTEIN
L11
SYMPORTIN 1

(Chaetomium
thermophilum) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C)
no annotation 		4 HIS C  69
ASP A 404
ASP C 127
TYR C 129
 None
 1.28A 2lh8A-5affC:
undetectable		 2lh8A-5affC:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 PRO A 638
HIS A 876
ASP A 871
ASP A 872
 None
 1.02A 2lh8A-5d0fA:
undetectable		 2lh8A-5d0fA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE

(Micromonospora
griseorubida) 		PF00067
(p450) 		4 PRO A 137
MET A 138
HIS A 229
TYR A 151
 None
 1.11A 2lh8A-5foiA:
undetectable		 2lh8A-5foiA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5u BETA-HEXOSAMINIDASE

(Pseudomonas
aeruginosa) 		PF00933
(Glyco_hydro_3) 		4 PRO A 164
HIS A 162
ASP A 245
ASP A 244
 None
 1.37A 2lh8A-5g5uA:
undetectable		 2lh8A-5g5uA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 4 PRO C 184
MET C 185
HIS C 189
ASP C 222
 None
 1.28A 2lh8A-5gp4C:
undetectable		 2lh8A-5gp4C:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 HIS A 148
ASP A 978
ASP A 979
TYR A 897
 None
 1.05A 2lh8A-5h42A:
undetectable		 2lh8A-5h42A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		4 PRO A 206
HIS A  46
ASP A  45
TYR A  41
 None
 1.14A 2lh8A-5hstA:
undetectable		 2lh8A-5hstA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 4 PRO D 245
HIS D 112
ASP D 114
TYR D 266
 None
 1.34A 2lh8A-5k59D:
undetectable		 2lh8A-5k59D:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l20 CLOSTRIPAIN-RELATED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03415
(Peptidase_C11)
no annotation 		4 HIS A 141
ASP B 205
ASP B 206
TYR B 208
 None
 1.45A 2lh8A-5l20A:
undetectable		 2lh8A-5l20A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljm SPERMATOGENESIS-ASSO
CIATED PROTEIN 2

(Homo sapiens) 		no annotation 4 PRO A   6
MET A   7
HIS A  53
ASP A 203
 None
 1.19A 2lh8A-5ljmA:
1.5		 2lh8A-5ljmA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 PRO A 385
MET A 387
ASP A 430
TYR A 485
 None
 1.45A 2lh8A-5m6uA:
1.7		 2lh8A-5m6uA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN
RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 1

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF00101
(RuBisCO_small)
PF02788
(RuBisCO_large_N) 		4 PRO I 107
HIS I  42
ASP A 165
TYR I  79
 None
 1.12A 2lh8A-5nv3I:
undetectable		 2lh8A-5nv3I:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 PRO A 137
HIS A 140
ASP A 166
TYR A 142
 None
CL  A1001 (-4.5A)
None
None
 1.01A 2lh8A-5nz7A:
undetectable		 2lh8A-5nz7A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		4 PRO F 324
MET F 325
ASP F 440
TYR F 439
 None
 1.40A 2lh8A-5odrF:
undetectable		 2lh8A-5odrF:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svw ADAGIO PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 4 PRO B 111
HIS B 121
ASP B 115
TYR B 113
 None
 1.38A 2lh8A-5svwB:
undetectable		 2lh8A-5svwB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Drosophila
melanogaster) 		PF01652
(IF4E) 		4 PRO A 114
HIS A 111
ASP A 104
TYR A 109
 None
 1.26A 2lh8A-5t47A:
undetectable		 2lh8A-5t47A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8e ARGININE KINASE

(Polybetes
pythagoricus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 HIS A  99
ASP A 263
ASP A 262
TYR A  75
 None
 1.43A 2lh8A-5u8eA:
undetectable		 2lh8A-5u8eA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucg STAGE II SPORULATION
PROTEIN E

(Bacillus
subtilis) 		PF07228
(SpoIIE) 		4 HIS A 637
ASP A 796
ASP A 610
TYR A 612
 None
 1.42A 2lh8A-5ucgA:
undetectable		 2lh8A-5ucgA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 4 PRO A 394
ASP A 415
ASP A 416
TYR A 420
 None
 1.38A 2lh8A-5uj1A:
undetectable		 2lh8A-5uj1A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7q 50S RIBOSOMAL
PROTEIN L19

(Mycobacterium
tuberculosis) 		PF01245
(Ribosomal_L19) 		4 PRO P  10
HIS P  76
ASP P  15
ASP P  14
 None
 1.44A 2lh8A-5v7qP:
undetectable		 2lh8A-5v7qP:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Homo sapiens) 		no annotation 4 PRO A 216
ASP A 192
ASP A 195
TYR A 222
 None
 1.34A 2lh8A-5vcsA:
undetectable		 2lh8A-5vcsA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjy DUTP PYROPHOSPHATASE

(Naegleria
fowleri) 		PF00692
(dUTPase) 		4 PRO A   4
HIS A  57
ASP A  83
TYR A  59
 None
 1.33A 2lh8A-5vjyA:
undetectable		 2lh8A-5vjyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0n LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		PF03466
(LysR_substrate) 		4 PRO A 108
MET A 106
ASP A 283
TYR A 288
 None
 1.47A 2lh8A-5x0nA:
undetectable		 2lh8A-5x0nA:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yj4 MAJOR PRION PROTEIN

(Homo sapiens) 		no annotation 4 PRO A 137
ASP A 144
ASP A 147
TYR A 150
 None
 1.47A 2lh8A-5yj4A:
9.1		 2lh8A-5yj4A:
82.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 PRO 2 900
MET 2 899
ASP 21097
ASP 21098
 None
 1.39A 2lh8A-5zvs2:
undetectable		 2lh8A-5zvs2:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 4 PRO A 280
ASP A 352
ASP A 350
TYR A 348
 None
 1.38A 2lh8A-6bs7A:
undetectable		 2lh8A-6bs7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf8 LYTIC
TRANSGLYCOSYLASE

(Campylobacter
jejuni) 		no annotation 4 PRO A 367
MET A 366
ASP A 374
TYR A 439
 None
 1.17A 2lh8A-6cf8A:
undetectable		 2lh8A-6cf8A:
18.18