SIMILAR PATTERNS OF AMINO ACIDS FOR 2LBD_A_REAA500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		5 CYH A 577
LEU A 667
ILE A 648
PHE A 644
GLY A 597
 None
 1.28A 2lbdA-1bf5A:
0.0		 2lbdA-1bf5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3n AGGLUTININ

(Helianthus
tuberosus) 		PF01419
(Jacalin) 		5 PHE A 130
ILE A  44
PHE A  46
GLY A  84
LEU A 120
 None
 1.25A 2lbdA-1c3nA:
undetectable		 2lbdA-1c3nA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		5 PHE A 610
ILE A 559
PHE A 560
GLY A 713
LEU A 618
 None
 1.28A 2lbdA-1d5fA:
0.0		 2lbdA-1d5fA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 PHE A 230
LYS A 236
CYH A 237
LEU A 271
MET A 272
ARG A 274
ILE A 275
ARG A 278
PHE A 288
SER A 289
GLY A 393
LEU A 400
 961  A 450 (-3.9A)
LMU  A 451 ( 3.7A)
961  A 450 (-3.6A)
961  A 450 (-3.6A)
961  A 450 (-3.1A)
None
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-4.6A)
961  A 450 (-2.5A)
961  A 450 ( 4.0A)
None
 0.42A 2lbdA-1exxA:
40.6		 2lbdA-1exxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		5 LEU A 290
ILE A 280
ARG A 281
PHE A 336
GLY A 324
 None
None
None
None
PLP  A 342 (-4.0A)
 1.23A 2lbdA-1f2dA:
undetectable		 2lbdA-1f2dA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 PHE A 712
ARG A 777
ILE A 776
GLY A 692
LEU A 740
 None
 1.17A 2lbdA-1hwwA:
undetectable		 2lbdA-1hwwA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4e CASPASE-8

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 ARG B2258
ILE B2257
ARG B2248
PHE B2244
GLY B2362
 None
 1.22A 2lbdA-1i4eB:
0.0		 2lbdA-1i4eB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		5 LEU B 227
ARG B 232
ILE B 233
GLY B 221
LEU B 246
 None
 1.30A 2lbdA-1kwcB:
undetectable		 2lbdA-1kwcB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		5 PHE A 215
MET A 242
ILE A 230
ARG A 231
GLY A 204
 None
 1.22A 2lbdA-1m9iA:
0.0		 2lbdA-1m9iA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		5 LYS A  13
LEU A 369
MET A 368
ARG A 364
LEU A 479
 None
 1.29A 2lbdA-1px8A:
undetectable		 2lbdA-1px8A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		5 LEU A 197
ILE A 194
PHE A 353
GLY A 384
LEU A 391
 None
 1.21A 2lbdA-1v4gA:
undetectable		 2lbdA-1v4gA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		5 PHE A 185
ARG A 164
ILE A 168
SER A 136
GLY A 207
 None
 1.18A 2lbdA-1v9aA:
undetectable		 2lbdA-1v9aA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm6 DIHYDRODIPICOLINATE
REDUCTASE

(Thermotoga
maritima) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 PHE A  98
LEU A  68
ILE A  46
PHE A  48
SER A  49
 NAD  A 300 (-4.8A)
None
None
NAD  A 300 (-4.7A)
NAD  A 300 (-4.4A)
 1.01A 2lbdA-1vm6A:
undetectable		 2lbdA-1vm6A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER
IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1)
PF16186
(Arm_3) 		5 PHE C 174
ILE C 150
ARG B  17
GLY C 142
LEU C 132
 None
 1.31A 2lbdA-1wa5C:
undetectable		 2lbdA-1wa5C:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		5 PHE 1 414
LYS 1 347
ILE 1 366
ARG 1 367
GLY 1 353
 None
 1.11A 2lbdA-1wao1:
undetectable		 2lbdA-1wao1:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 PHE A 221
LYS A 227
CYH A 228
LEU A 262
ARG A 265
ILE A 266
ARG A 269
PHE A 279
SER A 280
LEU A 391
 TTB  A   1 (-4.7A)
None
TTB  A   1 ( 3.8A)
TTB  A   1 (-3.9A)
None
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
None
 0.53A 2lbdA-1xapA:
38.3		 2lbdA-1xapA:
87.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 PHE A 221
LYS A 227
CYH A 228
LEU A 262
ARG A 265
PHE A 279
SER A 280
GLY A 384
LEU A 391
 TTB  A   1 (-4.7A)
None
TTB  A   1 ( 3.8A)
TTB  A   1 (-3.9A)
None
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.0A)
None
 0.65A 2lbdA-1xapA:
38.3		 2lbdA-1xapA:
87.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		10 PHE B 221
CYH B 228
LEU B 262
ARG B 265
ILE B 266
ARG B 269
PHE B 279
SER B 280
GLY B 384
LEU B 391
 9CR  B 600 ( 4.7A)
9CR  B 600 (-3.4A)
9CR  B 600 (-3.9A)
None
9CR  B 600 ( 3.8A)
9CR  B 600 (-3.8A)
9CR  B 600 (-4.5A)
9CR  B 600 (-3.0A)
9CR  B 600 ( 4.6A)
None
 0.55A 2lbdA-1xdkB:
37.7		 2lbdA-1xdkB:
79.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		6 PHE B 221
LYS B 227
LEU B 262
PHE B 279
GLY B 384
LEU B 391
 9CR  B 600 ( 4.7A)
None
9CR  B 600 (-3.9A)
9CR  B 600 (-4.5A)
9CR  B 600 ( 4.6A)
None
 1.07A 2lbdA-1xdkB:
37.7		 2lbdA-1xdkB:
79.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xew SMC PROTEIN

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		5 PHE Y1093
LYS X  26
ILE X  84
PHE X  86
GLY X  43
 None
 1.09A 2lbdA-1xewY:
undetectable		 2lbdA-1xewY:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y89 DEVB PROTEIN

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		5 ILE A 102
ARG A 114
PHE A 115
GLY A  37
LEU A 137
 None
 1.05A 2lbdA-1y89A:
undetectable		 2lbdA-1y89A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 PHE A 639
ARG A 867
PHE A 642
GLY A 858
LEU A 602
 None
 1.27A 2lbdA-1yguA:
undetectable		 2lbdA-1yguA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		5 PHE A 254
MET A  21
ILE A 179
PHE A 189
LEU A  31
 None
 1.29A 2lbdA-1zkdA:
undetectable		 2lbdA-1zkdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2do0 HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN M

(Homo sapiens) 		PF00076
(RRM_1) 		5 PHE A 223
PHE A 250
SER A 203
GLY A 265
LEU A 268
 None
 1.32A 2lbdA-2do0A:
undetectable		 2lbdA-2do0A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elj TRANSCRIPTIONAL
ADAPTER 2

(Saccharomyces
cerevisiae) 		PF04433
(SWIRM) 		5 LEU A  30
ARG A  77
ILE A  78
PHE A  82
LEU A  22
 None
 1.31A 2lbdA-2eljA:
undetectable		 2lbdA-2eljA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		5 LEU A 565
MET A 564
SER A 435
GLY A 466
LEU A 460
 None
 1.14A 2lbdA-2f5uA:
undetectable		 2lbdA-2f5uA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 LEU B 476
MET B 477
ILE B 772
GLY B 469
LEU B 466
 None
 0.99A 2lbdA-2fffB:
undetectable		 2lbdA-2fffB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PHE A  59
ILE A 196
PHE A 190
SER A 191
GLY A  68
 None
 1.01A 2lbdA-2fqdA:
undetectable		 2lbdA-2fqdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		5 PHE A 367
ILE A  12
ARG A   4
GLY A  38
LEU A 420
 None
 1.26A 2lbdA-2gq3A:
undetectable		 2lbdA-2gq3A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iae SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		5 PHE B 208
LYS B 256
LEU B 267
SER B 259
GLY B 229
 None
 1.31A 2lbdA-2iaeB:
undetectable		 2lbdA-2iaeB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 PHE A  52
LEU A  39
ILE A  44
GLY A  86
LEU A  82
 None
 1.20A 2lbdA-2id5A:
undetectable		 2lbdA-2id5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jch PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		5 LEU A 476
MET A 477
ILE A 772
GLY A 469
LEU A 466
 None
 1.00A 2lbdA-2jchA:
undetectable		 2lbdA-2jchA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A  85
ILE A  95
PHE A  99
GLY A 120
LEU A  38
 None
None
None
SO4  A   1 (-3.5A)
None
 1.07A 2lbdA-2r0bA:
undetectable		 2lbdA-2r0bA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6g PROGESTERONE
5-BETA-REDUCTASE

(Digitalis
lanata) 		PF01370
(Epimerase) 		5 CYH A 250
PHE A 375
SER A 371
GLY A 239
LEU A 310
 None
 1.23A 2lbdA-2v6gA:
undetectable		 2lbdA-2v6gA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn DTDP-4-KETO-6-DEOXY-
HEXOSE 3,4-ISOMERASE
GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF00067
(p450)
PF06722
(DUF1205) 		5 MET B  35
ARG B  37
ILE B  36
SER B 197
GLY A  87
 None
 1.23A 2lbdA-2yjnB:
undetectable		 2lbdA-2yjnB:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		5 LEU A 309
ILE A 308
SER A  73
GLY A 172
LEU A 125
 None
 1.07A 2lbdA-2z2zA:
undetectable		 2lbdA-2z2zA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb4 PROSTAGLANDIN
REDUCTASE 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 LEU A 252
ILE A 251
PHE A 229
SER A 161
LEU A 290
 None
None
None
None
5OP  A 600 (-3.7A)
 1.26A 2lbdA-2zb4A:
undetectable		 2lbdA-2zb4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zds PUTATIVE DNA-BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF01261
(AP_endonuc_2)
PF07582
(AP_endonuc_2_N) 		5 LYS A  65
CYH A  66
LEU A  33
GLY A  37
LEU A  14
 None
 1.05A 2lbdA-2zdsA:
undetectable		 2lbdA-2zdsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		5 PHE A 895
LEU A 868
ILE A 915
PHE A 877
SER A 874
 None
 1.21A 2lbdA-3a6pA:
undetectable		 2lbdA-3a6pA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co8 ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ARG A  10
ILE A  11
PHE A 246
GLY A 286
LEU A 290
 None
 1.19A 2lbdA-3co8A:
undetectable		 2lbdA-3co8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 CYH A 388
MET A 304
ILE A 307
GLY A 289
LEU A 199
 None
 1.16A 2lbdA-3dwbA:
0.9		 2lbdA-3dwbA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 LEU C 195
MET C 194
ILE C 193
SER C 210
GLY C 201
 None
 1.22A 2lbdA-3gzdC:
undetectable		 2lbdA-3gzdC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 PHE A   6
LEU A  76
ILE A  77
ARG A 106
GLY A  70
 None
 1.21A 2lbdA-3h2zA:
undetectable		 2lbdA-3h2zA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih6 PUTATIVE ZINC
PROTEASE

(Bordetella
pertussis) 		PF05193
(Peptidase_M16_C) 		5 PHE A 327
MET A 284
PHE A 329
SER A 255
GLY A 443
 None
 1.27A 2lbdA-3ih6A:
undetectable		 2lbdA-3ih6A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 PHE A 273
LYS A 509
ILE A 302
PHE A 324
LEU A 346
 None
 1.24A 2lbdA-3k4xA:
undetectable		 2lbdA-3k4xA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1i RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00638
(Ran_BP1) 		5 PHE B 174
MET B 126
ARG B 123
ILE B 124
GLY B 107
 None
 1.29A 2lbdA-3m1iB:
undetectable		 2lbdA-3m1iB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		5 LEU A 122
ARG A 119
PHE A  56
GLY A 128
LEU A 130
 None
None
None
EDO  A 235 ( 4.0A)
None
 1.30A 2lbdA-3mvuA:
2.4		 2lbdA-3mvuA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkh INTEGRASE

(Staphylococcus
aureus) 		PF00589
(Phage_integrase) 		5 PHE A  39
LYS A 108
ILE A  53
PHE A 130
GLY A  97
 None
 1.24A 2lbdA-3nkhA:
undetectable		 2lbdA-3nkhA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnw CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 PHE B 288
LYS B 285
ILE A 157
PHE B 245
GLY A  45
 None
 1.24A 2lbdA-3qnwB:
undetectable		 2lbdA-3qnwB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli) 		PF02016
(Peptidase_S66) 		5 PHE A 159
LEU A 141
ILE A  19
PHE A  48
GLY A 116
 None
 1.30A 2lbdA-3tlzA:
undetectable		 2lbdA-3tlzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 LYS A 378
LEU A 421
ILE A 420
GLY A 427
LEU A 352
 None
ACY  A 511 (-4.4A)
ACY  A 511 ( 3.9A)
None
None
 1.31A 2lbdA-3zx2A:
undetectable		 2lbdA-3zx2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebr UBIQUITIN-LIKE-CONJU
GATING ENZYME ATG10

(Saccharomyces
cerevisiae) 		PF03987
(Autophagy_act_C) 		5 PHE A  20
LEU A  78
PHE A 159
SER A 160
GLY A  37
 None
 1.27A 2lbdA-4ebrA:
undetectable		 2lbdA-4ebrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		5 PHE A  72
LEU A  86
ARG A  83
GLY A 365
LEU A 368
 None
None
DDZ  A  79 ( 4.2A)
None
None
 1.30A 2lbdA-4fdjA:
undetectable		 2lbdA-4fdjA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gw9 BACTERIOPHYTOCHROME

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF00989
(PAS)
PF01590
(GAF)
PF08446
(PAS_2) 		5 PHE A 547
LEU A 561
ILE A 540
GLY A 566
LEU A 594
 None
 1.01A 2lbdA-4gw9A:
undetectable		 2lbdA-4gw9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hav RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00638
(Ran_BP1) 		5 PHE B 174
MET B 126
ARG B 123
ILE B 124
GLY B 107
 None
 1.29A 2lbdA-4havB:
undetectable		 2lbdA-4havB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hva CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 PHE A 288
LYS A 285
ILE A 157
PHE A 245
GLY A  45
 None
 1.25A 2lbdA-4hvaA:
undetectable		 2lbdA-4hvaA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		5 LEU A 285
ILE A 237
PHE A 229
GLY A 243
LEU A 250
 None
 1.27A 2lbdA-4infA:
undetectable		 2lbdA-4infA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 PHE A   6
LYS A 242
ILE A  35
PHE A  57
LEU A  79
 None
 1.22A 2lbdA-4l60A:
undetectable		 2lbdA-4l60A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 5 LEU A 230
ARG A 181
ILE A 180
PHE A 148
GLY A 266
 None
 0.96A 2lbdA-4nuzA:
undetectable		 2lbdA-4nuzA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 PHE A 673
LYS A 632
MET A 689
ILE A 693
PHE A 700
 None
 1.06A 2lbdA-4o1oA:
undetectable		 2lbdA-4o1oA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ord THIOESTERASE
SUPERFAMILY MEMBER 2

(Danio rerio) 		PF03061
(4HBT) 		5 LYS A  44
LEU A  64
ILE A  68
GLY A 133
LEU A 129
 None
 1.27A 2lbdA-4ordA:
undetectable		 2lbdA-4ordA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		5 LYS A 281
LEU A 230
ILE A 254
PHE A 246
GLY A 227
 None
 1.32A 2lbdA-4qbuA:
undetectable		 2lbdA-4qbuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		5 PHE B 154
MET B 100
ARG B 139
PHE B 141
GLY B  55
 None
SAM  B 301 (-4.2A)
EDO  B 303 ( 3.7A)
None
SAM  B 301 (-3.7A)
 1.16A 2lbdA-4qtuB:
undetectable		 2lbdA-4qtuB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A3231
ARG A3230
PHE A3741
GLY A3388
LEU A3158
 None
 1.23A 2lbdA-4tktA:
undetectable		 2lbdA-4tktA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		5 LEU A  57
ARG A 414
SER A 403
GLY A  64
LEU A 357
 None
 1.22A 2lbdA-4uhmA:
undetectable		 2lbdA-4uhmA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP

(Pseudomonas
putida) 		PF03480
(DctP) 		5 LEU A 315
MET A 316
ILE A 319
GLY A 309
LEU A 175
 None
 1.02A 2lbdA-4xfeA:
undetectable		 2lbdA-4xfeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 LYS A  88
LEU A  85
ILE A   6
PHE A  23
GLY A 209
 CIT  A 501 (-2.6A)
None
None
None
None
 1.30A 2lbdA-4xg0A:
undetectable		 2lbdA-4xg0A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F

(Staphylococcus
aureus) 		PF01370
(Epimerase) 		5 PHE A 231
LEU A 212
ILE A 146
PHE A 134
GLY A 206
 None
 1.29A 2lbdA-4yrdA:
undetectable		 2lbdA-4yrdA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2414
ARG A2413
PHE A2923
GLY A2564
LEU A2338
 None
 1.20A 2lbdA-4z37A:
undetectable		 2lbdA-4z37A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqi D-ALANINE--D-ALANINE
LIGASE

(Yersinia pestis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LYS A 101
LEU A  93
ARG A  99
SER A 146
GLY A  87
 None
 1.23A 2lbdA-4zqiA:
undetectable		 2lbdA-4zqiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		5 ARG C 177
ILE C 153
PHE C  90
GLY C 205
LEU C 208
 None
 1.31A 2lbdA-5a8rC:
undetectable		 2lbdA-5a8rC:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		5 PHE A 281
LEU A 365
ILE A 302
SER A 199
LEU A 274
 None
 1.08A 2lbdA-5feiA:
undetectable		 2lbdA-5feiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		5 LEU A 290
ARG A 142
ILE A 141
PHE A 266
GLY A 407
 None
 1.00A 2lbdA-5h71A:
undetectable		 2lbdA-5h71A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 LEU B 314
ILE B 315
PHE B 317
SER B 318
LEU B 264
 None
 1.03A 2lbdA-5hz1B:
undetectable		 2lbdA-5hz1B:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 CYH B1166
LEU B1168
MET B1169
ILE B1162
LEU A1397
 ZN  B1301 (-2.2A)
None
None
None
None
 1.23A 2lbdA-5ip9B:
undetectable		 2lbdA-5ip9B:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 LEU A 884
PHE A 853
SER A 880
GLY A 859
LEU A 835
 None
 1.16A 2lbdA-5irmA:
undetectable		 2lbdA-5irmA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S2

(Pyrococcus
abyssi) 		PF00318
(Ribosomal_S2) 		5 PHE B  83
ILE B 116
SER B  71
GLY B  56
LEU B 176
 None
 1.25A 2lbdA-5jb3B:
undetectable		 2lbdA-5jb3B:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 PHE A 228
CYH A 235
LEU A 269
ARG A 272
ILE A 273
ARG A 276
PHE A 286
SER A 287
GLY A 391
LEU A 398
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
None
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-4.7A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.1A)
None
 0.71A 2lbdA-5k13A:
36.5		 2lbdA-5k13A:
82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 PHE A 228
LYS A 234
CYH A 235
LEU A 269
ARG A 272
ILE A 273
ARG A 276
PHE A 286
GLY A 391
LEU A 398
 6Q7  A 501 (-3.9A)
None
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
None
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-4.7A)
6Q7  A 501 ( 4.1A)
None
 0.65A 2lbdA-5k13A:
36.5		 2lbdA-5k13A:
82.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 121
ILE A 280
SER A 285
GLY A   8
LEU A  33
 None
 1.26A 2lbdA-5ks1A:
undetectable		 2lbdA-5ks1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 5 CYH A 250
PHE A 375
SER A 371
GLY A 239
LEU A 310
 None
 1.26A 2lbdA-5mlhA:
undetectable		 2lbdA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 5 PHE A 214
LEU A 191
ILE A 224
PHE A 225
GLY A  66
 None
None
None
None
SNN  A 176 ( 3.7A)
 1.21A 2lbdA-5nijA:
undetectable		 2lbdA-5nijA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nrm ENDOGLUCANASE

(Acetivibrio
cellulolyticus) 		no annotation 5 PHE A  38
LYS A  74
LEU A  98
ILE A   8
GLY A  55
 None
 1.03A 2lbdA-5nrmA:
undetectable		 2lbdA-5nrmA:
16.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 10 PHE B 221
CYH B 228
LEU B 262
ARG B 265
ILE B 266
ARG B 269
PHE B 279
SER B 280
GLY B 384
LEU B 391
 REA  B 503 ( 4.8A)
REA  B 503 (-3.1A)
REA  B 503 (-3.9A)
None
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-4.4A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.4A)
None
 0.58A 2lbdA-5uanB:
38.0		 2lbdA-5uanB:
64.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 6 PHE B 221
LYS B 227
LEU B 262
PHE B 279
GLY B 384
LEU B 391
 REA  B 503 ( 4.8A)
None
REA  B 503 (-3.9A)
REA  B 503 (-4.4A)
REA  B 503 ( 4.4A)
None
 1.13A 2lbdA-5uanB:
38.0		 2lbdA-5uanB:
64.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vft PROTEASOME SUBUNIT
BETA TYPE-4

(Homo sapiens) 		no annotation 5 LEU T  51
MET T  43
ARG T  41
SER T  54
GLY T  68
 None
 1.05A 2lbdA-5vftT:
undetectable		 2lbdA-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		5 LEU A  36
ARG A  33
ILE A  32
PHE A  57
GLY A  11
 None
 1.28A 2lbdA-5vn6A:
undetectable		 2lbdA-5vn6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LYS A 447
CYH A 423
LEU A 457
ILE A 459
GLY A  16
 None
 1.20A 2lbdA-5vniA:
undetectable		 2lbdA-5vniA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 PHE A 197
LEU A 226
ILE A 228
SER A 233
GLY A 201
 None
 1.20A 2lbdA-5wblA:
undetectable		 2lbdA-5wblA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 5 LEU A 166
ARG A 156
PHE A  63
SER A  64
LEU A 204
 None
 1.28A 2lbdA-5x3hA:
undetectable		 2lbdA-5x3hA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		5 PHE A1093
LYS A  26
ILE A  84
PHE A  86
GLY A  43
 None
 1.30A 2lbdA-5xeiA:
undetectable		 2lbdA-5xeiA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10588
(NADH-G_4Fe-4S_3)
PF10589
(NADH_4Fe-4S)
PF13459
(Fer4_15)
PF13510
(Fer2_4) 		5 CYH B 159
LEU B 171
ILE B 173
GLY A  44
LEU A  41
 SF4  B 302 (-2.2A)
None
None
None
None
 1.20A 2lbdA-5xfaB:
undetectable		 2lbdA-5xfaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		5 PHE A1093
LYS A  26
ILE A  84
PHE A  86
GLY A  43
 None
 1.18A 2lbdA-5xnsA:
undetectable		 2lbdA-5xnsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 LEU A  23
MET A  24
ARG A  26
ILE A  27
ARG A  30
 None
 0.94A 2lbdA-5yu1A:
undetectable		 2lbdA-5yu1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbi PEPTIDE ASPARAGINYL
LIGASE

(Viola
canadensis) 		no annotation 5 PHE A 203
LEU A 180
ILE A 213
PHE A 214
GLY A  55
 None
 1.12A 2lbdA-5zbiA:
undetectable		 2lbdA-5zbiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Streptococcus
pyogenes;
Vibrio cholerae) 		no annotation 5 LEU A 230
ARG A 181
ILE A 180
PHE A 148
GLY A 266
 None
MAN  A1305 ( 4.7A)
None
None
None
 1.21A 2lbdA-6en3A:
undetectable		 2lbdA-6en3A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD

(Acetobacterium
woodii) 		no annotation 5 LEU C  13
MET C   9
ILE B 193
SER C  61
LEU B  42
 None
 0.95A 2lbdA-6fahC:
undetectable		 2lbdA-6fahC:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 5 LEU A 218
ILE A 193
ARG A 202
GLY A 215
LEU A 175
 None
 1.26A 2lbdA-6fv5A:
undetectable		 2lbdA-6fv5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 11 PHE A 230
LYS A 236
CYH A 237
LEU A 271
ARG A 274
ILE A 275
ARG A 278
PHE A 288
SER A 289
GLY A 393
LEU A 400
 E9T  A 501 (-4.3A)
None
E9T  A 501 (-3.6A)
E9T  A 501 (-3.6A)
None
E9T  A 501 (-3.8A)
E9T  A 501 (-3.1A)
E9T  A 501 (-4.7A)
E9T  A 501 (-2.6A)
E9T  A 501 (-3.7A)
None
 0.45A 2lbdA-6fx0A:
39.9		 2lbdA-6fx0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 10 PHE A 230
LYS A 236
CYH A 237
LEU A 271
MET A 272
ARG A 274
ILE A 275
ARG A 278
PHE A 288
SER A 289
 E9T  A 501 (-4.3A)
None
E9T  A 501 (-3.6A)
E9T  A 501 (-3.6A)
None
None
E9T  A 501 (-3.8A)
E9T  A 501 (-3.1A)
E9T  A 501 (-4.7A)
E9T  A 501 (-2.6A)
 0.73A 2lbdA-6fx0A:
39.9		 2lbdA-6fx0A:
16.80