SIMILAR PATTERNS OF AMINO ACIDS FOR 2L8M_A_CAMA415_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)


(Homo sapiens)
PF00168
(C2)
PF01735
(PLA2_B)
5 THR A 128
LEU A  91
VAL A  46
THR A  60
VAL A  24
None
1.31A 2l8mA-1cjyA:
0.0
2l8mA-1cjyA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2y TRYPAREDOXIN
PEROXIDASE


(Crithidia
fasciculata)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
5 VAL A  40
VAL A 153
ASP A  62
ILE A 157
VAL A 156
None
1.32A 2l8mA-1e2yA:
0.0
2l8mA-1e2yA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL


(Trypanosoma
brucei)
PF00274
(Glycolytic)
5 THR A 278
LEU A 237
VAL A 193
THR A  28
VAL A 112
None
1.38A 2l8mA-1f2jA:
0.0
2l8mA-1f2jA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F


(Escherichia
coli)
PF07992
(Pyr_redox_2)
5 THR A 322
VAL A 462
THR A 478
ILE A 318
VAL A 483
FAD  A 522 (-4.1A)
None
None
None
None
1.29A 2l8mA-1fl2A:
0.0
2l8mA-1fl2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans)
PF00118
(Cpn60_TCP1)
5 THR A  91
LEU A  95
THR A 124
ILE A 131
VAL A 128
None
1.50A 2l8mA-1iokA:
0.0
2l8mA-1iokA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9w 3-DEHYDROQUINATE
DEHYDRATASE AROD


(Salmonella
enterica)
PF01487
(DHquinase_I)
5 TYR A  97
VAL A 139
ASP A 114
ILE A 113
VAL A 138
None
1.45A 2l8mA-1l9wA:
0.0
2l8mA-1l9wA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o70 FASCICLIN I

(Drosophila
melanogaster)
PF02469
(Fasciclin)
5 THR A 504
LEU A 568
VAL A 566
ILE A 588
VAL A 579
None
1.49A 2l8mA-1o70A:
0.0
2l8mA-1o70A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o73 TRYPAREDOXIN

(Trypanosoma
brucei)
PF13905
(Thioredoxin_8)
5 THR A  96
LEU A  89
VAL A  66
ILE A 115
VAL A  31
None
1.43A 2l8mA-1o73A:
0.0
2l8mA-1o73A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC


(Shigella
flexneri)
PF03932
(CutC)
5 LEU A  95
VAL A 101
THR A 133
VAL A 145
ILE A 142
None
1.42A 2l8mA-1twdA:
0.0
2l8mA-1twdA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis)
PF07745
(Glyco_hydro_53)
5 VAL A 261
THR A 264
VAL A 300
ILE A 304
VAL A 303
None
1.38A 2l8mA-1ur4A:
undetectable
2l8mA-1ur4A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA


(Escherichia
coli)
PF01938
(TRAM)
PF05958
(tRNA_U5-meth_tr)
5 LEU A 279
VAL A 284
VAL A 311
ASP A 292
VAL A 290
None
1.33A 2l8mA-1uwvA:
undetectable
2l8mA-1uwvA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq7 50S RIBOSOMAL
PROTEIN L30P


(Haloarcula
marismortui)
PF00327
(Ribosomal_L30)
5 LEU W 100
THR W  88
VAL W  79
ILE W  93
VAL W  84
None
1.32A 2l8mA-1vq7W:
undetectable
2l8mA-1vq7W:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae)
PF03835
(Rad4)
5 THR A 297
VAL A 267
ASP A 268
ILE A 259
VAL A 266
None
1.49A 2l8mA-1x3wA:
undetectable
2l8mA-1x3wA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y11 HYPOTHETICAL PROTEIN
RV1264/MT1302


(Mycobacterium
tuberculosis)
PF00211
(Guanylate_cyc)
PF16701
(Ad_Cy_reg)
5 THR A 217
LEU A 277
VAL A 281
VAL A 374
VAL A 333
None
1.38A 2l8mA-1y11A:
undetectable
2l8mA-1y11A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A


(Mus musculus)
PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
5 THR A 481
VAL A 341
ASP A 475
ILE A 469
VAL A 467
None
1.47A 2l8mA-1y1uA:
undetectable
2l8mA-1y1uA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT


(Methanocaldococcus
jannaschii)
PF01420
(Methylase_S)
5 THR A 111
LEU A  92
VAL A  91
VAL A 158
ILE A  32
None
1.46A 2l8mA-1yf2A:
undetectable
2l8mA-1yf2A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5j RAS-RELATED PROTEIN
RAB-2B


(Homo sapiens)
PF00071
(Ras)
5 THR A 168
VAL A 161
THR A 153
VAL A  90
ILE A  16
None
1.34A 2l8mA-2a5jA:
undetectable
2l8mA-2a5jA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5j RAS-RELATED PROTEIN
RAB-2B


(Homo sapiens)
PF00071
(Ras)
5 TYR A  14
THR A 168
THR A 153
VAL A  90
ILE A  16
None
1.36A 2l8mA-2a5jA:
undetectable
2l8mA-2a5jA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE


(Escherichia
coli;
Escherichia
coli)
PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept)
5 VAL A 287
VAL B 496
ASP B 500
ILE B 499
VAL B 495
None
1.32A 2l8mA-2e0xA:
undetectable
2l8mA-2e0xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 LEU A 597
VAL A 599
VAL A 535
ASP A 538
VAL A 573
None
1.28A 2l8mA-2e6kA:
undetectable
2l8mA-2e6kA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Thermus
thermophilus)
PF00202
(Aminotran_3)
5 TYR A  57
THR A 416
LEU A 387
VAL A 350
ILE A 357
None
1.17A 2l8mA-2e7uA:
undetectable
2l8mA-2e7uA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eeo ASPARTATE
1-DECARBOXYLASE
ASPARTATE
1-DECARBOXYLASE


(Thermus
thermophilus;
Thermus
thermophilus)
PF02261
(Asp_decarbox)
PF02261
(Asp_decarbox)
5 THR B  57
LEU B  55
VAL B  79
ILE B  69
VAL A  15
FUM  B 501 ( 3.6A)
None
None
None
None
1.46A 2l8mA-2eeoB:
undetectable
2l8mA-2eeoB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae)
PF01843
(DIL)
5 THR X 312
LEU X 283
VAL X 196
VAL X 260
ASP X 261
None
1.44A 2l8mA-2f6hX:
undetectable
2l8mA-2f6hX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gax HYPOTHETICAL PROTEIN
ATU0240


(Agrobacterium
fabrum)
PF09391
(DUF2000)
5 LEU A  14
THR A  23
VAL A  60
ILE A   9
VAL A   8
None
1.35A 2l8mA-2gaxA:
undetectable
2l8mA-2gaxA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gki NUCLEASE

(Mus musculus)
PF07686
(V-set)
5 THR A 266
LEU A 169
VAL A 171
ILE A 239
VAL A 242
None
1.46A 2l8mA-2gkiA:
undetectable
2l8mA-2gkiA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
7 THR A 101
LEU A 244
THR A 252
VAL A 295
ASP A 297
ILE A 395
VAL A 396
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
None
0.92A 2l8mA-2m56A:
58.8
2l8mA-2m56A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
7 THR A 101
LEU A 244
VAL A 247
THR A 252
VAL A 295
ASP A 297
ILE A 395
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
0.95A 2l8mA-2m56A:
58.8
2l8mA-2m56A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
7 TYR A  96
THR A 101
LEU A 244
THR A 252
VAL A 295
ILE A 395
VAL A 396
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
None
None
0.79A 2l8mA-2m56A:
58.8
2l8mA-2m56A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
7 TYR A  96
THR A 101
LEU A 244
VAL A 247
THR A 252
VAL A 295
ILE A 395
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
None
0.84A 2l8mA-2m56A:
58.8
2l8mA-2m56A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
7 TYR A  96
THR A 101
LEU A 244
VAL A 247
THR A 252
VAL A 396
ILE A 395
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.4A)
None
None
1.43A 2l8mA-2m56A:
58.8
2l8mA-2m56A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF


(Thermotoga
maritima)
PF00977
(His_biosynth)
5 VAL A 195
THR A 199
VAL A 165
ILE A 134
VAL A 162
None
1.42A 2l8mA-2w6rA:
undetectable
2l8mA-2w6rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B


(Streptococcus
pneumoniae)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 TYR A 176
VAL A 104
VAL A  79
ILE A 192
VAL A  80
None
1.12A 2l8mA-2waeA:
undetectable
2l8mA-2waeA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB


(Streptococcus
pneumoniae)
no annotation 5 THR A  40
LEU A 106
VAL A 133
ASP A   3
VAL A 195
None
1.21A 2l8mA-2wjfA:
undetectable
2l8mA-2wjfA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD


(Sulfurisphaera
tokodaii)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 LEU A  60
VAL A  61
THR A  63
ILE A  76
VAL A  72
None
1.39A 2l8mA-2z0mA:
undetectable
2l8mA-2z0mA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE


(Pyrococcus
horikoshii)
PF01177
(Asp_Glu_race)
5 LEU A 111
VAL A 115
VAL A 143
ILE A 190
VAL A 118
None
1.32A 2l8mA-2zskA:
undetectable
2l8mA-2zskA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c19 UNCHARACTERIZED
PROTEIN MK0293


(Methanopyrus
kandleri)
PF01969
(DUF111)
5 THR A 145
LEU A 168
VAL A 166
VAL A 116
VAL A 105
None
1.28A 2l8mA-3c19A:
undetectable
2l8mA-3c19A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c24 PUTATIVE
OXIDOREDUCTASE


(Jannaschia sp.
CCS1)
PF03807
(F420_oxidored)
PF16896
(PGDH_C)
5 VAL A  70
THR A  94
ASP A  65
ILE A  64
VAL A  90
None
GOL  A 288 (-3.2A)
None
None
None
1.50A 2l8mA-3c24A:
undetectable
2l8mA-3c24A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch7 6-PHOSPHOGLUCONOLACT
ONASE


(Leishmania
braziliensis)
PF01182
(Glucosamine_iso)
5 TYR A  53
LEU A 218
VAL A 216
ILE A  25
VAL A  24
None
1.46A 2l8mA-3ch7A:
undetectable
2l8mA-3ch7A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cje OSMC-LIKE PROTEIN

(Jannaschia sp.
CCS1)
PF02566
(OsmC)
5 VAL A  73
THR A  70
ASP A 118
ILE A 119
VAL A  93
None
1.40A 2l8mA-3cjeA:
undetectable
2l8mA-3cjeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE


(Corynebacterium
diphtheriae)
PF12897
(Aminotran_MocR)
5 LEU A 363
VAL A 360
THR A 356
VAL A 336
VAL A 352
None
1.33A 2l8mA-3d6kA:
undetectable
2l8mA-3d6kA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dx5 UNCHARACTERIZED
PROTEIN ASBF


(Bacillus
anthracis)
PF01261
(AP_endonuc_2)
5 TYR A 121
LEU A 158
VAL A 162
VAL A 139
ILE A 128
None
1.45A 2l8mA-3dx5A:
undetectable
2l8mA-3dx5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus)
PF00972
(Flavi_NS5)
PF01728
(FtsJ)
5 THR A 236
VAL A 183
THR A 161
ILE A 192
VAL A 191
None
1.07A 2l8mA-3eluA:
undetectable
2l8mA-3eluA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emv URIDINE
PHOSPHORYLASE,
PUTATIVE


(Plasmodium
vivax)
PF01048
(PNP_UDP_1)
5 LEU A 139
VAL A 135
VAL A  19
ILE A  87
VAL A  86
None
1.19A 2l8mA-3emvA:
undetectable
2l8mA-3emvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE


(Staphylococcus
haemolyticus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 VAL A 121
THR A 303
VAL A 306
ILE A 333
VAL A 332
None
1.39A 2l8mA-3fbgA:
undetectable
2l8mA-3fbgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA


(Bacillus
subtilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 TYR A 313
THR A  90
VAL A  77
ILE A  78
VAL A  79
None
1.34A 2l8mA-3gdoA:
undetectable
2l8mA-3gdoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574


(Streptomyces
avermitilis)
PF04672
(Methyltransf_19)
5 LEU A 185
VAL A 182
VAL A 172
ILE A 168
VAL A 169
None
None
None
SAH  A 277 (-4.0A)
None
1.35A 2l8mA-3go4A:
undetectable
2l8mA-3go4A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE


(Yersinia pestis)
PF00709
(Adenylsucc_synt)
5 TYR A 399
VAL A 267
THR A  10
ILE A 313
VAL A 316
None
1.41A 2l8mA-3hidA:
undetectable
2l8mA-3hidA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1)
PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind)
5 LEU A 374
VAL A 370
THR A 365
ILE A 148
VAL A 437
None
1.45A 2l8mA-3js8A:
undetectable
2l8mA-3js8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lz8 PUTATIVE CHAPERONE
DNAJ


(Klebsiella
pneumoniae)
PF01556
(DnaJ_C)
5 THR A 130
VAL A 168
ASP A 169
ILE A 195
VAL A 167
None
1.44A 2l8mA-3lz8A:
undetectable
2l8mA-3lz8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tco THIOREDOXIN (TRXA-1)

(Sulfolobus
solfataricus)
PF00085
(Thioredoxin)
5 TYR A  95
LEU A  83
ASP A  39
ILE A  42
VAL A  41
None
1.25A 2l8mA-3tcoA:
undetectable
2l8mA-3tcoA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmc UNCHARACTERIZED
PROTEIN


(Bdellovibrio
bacteriovorus)
PF13487
(HD_5)
5 THR A 272
VAL A 152
THR A 156
ILE A 140
VAL A 137
DMS  A 312 (-4.3A)
None
None
None
None
1.20A 2l8mA-3tmcA:
undetectable
2l8mA-3tmcA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc0 ENVELOPE PROTEIN

(Dengue virus)
PF00869
(Flavi_glycoprot)
5 LEU A  25
VAL A  31
THR A  33
VAL A  21
ASP A  22
None
1.38A 2l8mA-3uc0A:
undetectable
2l8mA-3uc0A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE


(Mycolicibacterium
smegmatis)
PF01565
(FAD_binding_4)
PF04030
(ALO)
5 LEU A 158
VAL A 165
VAL A  47
ILE A  43
VAL A  44
None
1.00A 2l8mA-4autA:
undetectable
2l8mA-4autA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 TYR A 329
THR A 262
LEU A 286
VAL A 343
VAL A 336
None
1.48A 2l8mA-4bziA:
undetectable
2l8mA-4bziA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
7 THR A 103
LEU A 252
THR A 260
VAL A 303
ASP A 305
ILE A 403
VAL A 404
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
None
GOL  A1419 (-3.5A)
0.94A 2l8mA-4c9mA:
53.4
2l8mA-4c9mA:
45.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
7 TYR A  98
THR A 103
LEU A 252
THR A 260
VAL A 303
ILE A 403
VAL A 404
None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
None
GOL  A1419 (-3.5A)
0.86A 2l8mA-4c9mA:
53.4
2l8mA-4c9mA:
45.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ciu CHAPERONE PROTEIN
CLPB


(Escherichia
coli)
PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small)
5 LEU A 566
VAL A 580
VAL A 673
ILE A 715
VAL A 713
None
1.37A 2l8mA-4ciuA:
undetectable
2l8mA-4ciuA:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 THR A 101
THR A 258
VAL A 301
ILE A 401
VAL A 402
HEM  A 501 ( 4.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
None
None
0.67A 2l8mA-4dxyA:
48.5
2l8mA-4dxyA:
46.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct)
PF00977
(His_biosynth)
5 VAL A 107
THR A 149
ASP A 130
ILE A 129
VAL A 140
None
1.44A 2l8mA-4evzA:
undetectable
2l8mA-4evzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)


(Mus musculus)
PF07686
(V-set)
5 THR L 102
LEU L  11
VAL L  13
ILE L  75
VAL L  78
None
1.46A 2l8mA-4ffyL:
undetectable
2l8mA-4ffyL:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnr CHEMOTAXIS PROTEIN
CHEY


(Vibrio cholerae)
PF00072
(Response_reg)
5 TYR A  26
LEU A 119
VAL A 118
THR A  99
ILE A  50
None
1.47A 2l8mA-4hnrA:
undetectable
2l8mA-4hnrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iys METAL TRANSPORTER
CNNM2


(Homo sapiens)
PF00571
(CBS)
5 THR A 469
LEU A 465
THR A 515
VAL A 483
ILE A 481
None
1.24A 2l8mA-4iysA:
undetectable
2l8mA-4iysA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1


(Arabidopsis
thaliana)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 TYR A 140
VAL A 146
VAL A 180
ILE A 158
VAL A 156
None
1.38A 2l8mA-4j0mA:
undetectable
2l8mA-4j0mA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN


(Streptococcus
pneumoniae)
PF01497
(Peripla_BP_2)
5 LEU A  65
VAL A  88
THR A  85
VAL A  99
VAL A  96
None
None
SO4  A 404 ( 4.7A)
None
None
1.38A 2l8mA-4jccA:
undetectable
2l8mA-4jccA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I


(Escherichia
coli)
PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C)
5 TYR A 284
VAL A 298
VAL A 348
ILE A 350
VAL A 347
None
1.22A 2l8mA-4js5A:
undetectable
2l8mA-4js5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k46 ADENYLATE KINASE

(Photobacterium
profundum)
PF00406
(ADK)
PF05191
(ADK_lid)
5 TYR A 171
THR A 199
ASP A 113
ILE A 116
VAL A 115
None
1.39A 2l8mA-4k46A:
undetectable
2l8mA-4k46A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus)
PF00972
(Flavi_NS5)
PF01728
(FtsJ)
5 THR A 236
VAL A 183
THR A 161
ILE A 192
VAL A 191
None
1.10A 2l8mA-4k6mA:
undetectable
2l8mA-4k6mA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdy PERIPLASMIC BINDING
PROTEIN


(Mycolicibacterium
smegmatis)
PF01497
(Peripla_BP_2)
5 THR A 125
VAL A  55
VAL A  69
ASP A  65
VAL A  71
None
1.38A 2l8mA-4mdyA:
undetectable
2l8mA-4mdyA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq3 INTEGRASE

(Feline
immunodeficiency
virus)
PF00665
(rve)
5 THR A  99
LEU A  76
VAL A  77
ASP A 118
VAL A 153
None
1.35A 2l8mA-4mq3A:
undetectable
2l8mA-4mq3A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Methanocaldococcus
jannaschii)
PF02350
(Epimerase_2)
5 THR A  71
LEU A  75
VAL A 105
VAL A  92
ILE A   6
None
1.30A 2l8mA-4nesA:
undetectable
2l8mA-4nesA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4


(Drosophila
melanogaster)
no annotation 5 LEU A 409
VAL A 414
THR A 391
VAL A 495
VAL A 492
None
1.49A 2l8mA-4nk7A:
undetectable
2l8mA-4nk7A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4n HIV-1 GP120

(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 THR A 387
LEU A 416
VAL A 333
ILE A 449
VAL A 292
None
1.38A 2l8mA-4r4nA:
undetectable
2l8mA-4r4nA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwr STAGE II SPORULATION
PROTEIN D


(Bacillus
anthracis)
PF08486
(SpoIID)
5 THR A 288
LEU A 270
VAL A 264
ILE A 240
VAL A 252
None
1.46A 2l8mA-4rwrA:
undetectable
2l8mA-4rwrA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx4 HIV-1 CLADE A
Q842.D12 GP120


(Human
immunodeficiency
virus 1)
no annotation 5 THR G 387
LEU G 416
VAL G 333
ILE G 449
VAL G 292
None
1.49A 2l8mA-4rx4G:
undetectable
2l8mA-4rx4G:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1j PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Leishmania
donovani)
PF00160
(Pro_isomerase)
5 LEU A  40
VAL A 179
THR A 167
ILE A  85
VAL A  79
None
1.39A 2l8mA-4s1jA:
undetectable
2l8mA-4s1jA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis)
PF01979
(Amidohydro_1)
5 VAL A  15
THR A  17
VAL A 387
ILE A  33
VAL A 386
None
1.40A 2l8mA-4tqtA:
undetectable
2l8mA-4tqtA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB


(Thermus
thermophilus)
PF02872
(5_nucleotid_C)
5 TYR A 518
THR A 436
LEU A 541
VAL A 400
ASP A 393
None
1.44A 2l8mA-4uwqA:
undetectable
2l8mA-4uwqA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 LEU A 192
VAL A 277
THR A 274
ILE A 233
VAL A 232
None
1.48A 2l8mA-4w7sA:
undetectable
2l8mA-4w7sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F


(Escherichia
coli)
PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3)
5 THR A 322
VAL A 462
THR A 478
ILE A 318
VAL A 483
FAD  A 700 (-4.0A)
None
None
None
None
1.31A 2l8mA-4xvgA:
undetectable
2l8mA-4xvgA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 THR G 387
LEU G 416
VAL G 333
ILE G 449
VAL G 292
None
1.40A 2l8mA-4ydiG:
undetectable
2l8mA-4ydiG:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE


(Chlamydomonas
reinhardtii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 228
VAL A 183
THR A 186
ILE A 220
VAL A 215
None
1.48A 2l8mA-4zgsA:
undetectable
2l8mA-4zgsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpm PROTEIN PCDHAC2

(Mus musculus)
PF00028
(Cadherin)
PF08266
(Cadherin_2)
5 THR A 219
LEU A 310
VAL A 311
VAL A 275
VAL A 234
None
1.43A 2l8mA-4zpmA:
undetectable
2l8mA-4zpmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN


(Macaca mulatta)
PF07654
(C1-set)
PF07686
(V-set)
5 THR H  67
LEU H  80
VAL H  20
ASP H  86
VAL H 109
None
1.22A 2l8mA-5dd5H:
undetectable
2l8mA-5dd5H:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG


(Homo sapiens)
PF02724
(CDC45)
5 VAL A 229
THR A 225
VAL A 376
ASP A 375
VAL A 377
EDO  A 602 ( 4.9A)
None
EDO  A 601 (-3.6A)
None
None
1.35A 2l8mA-5dgoA:
undetectable
2l8mA-5dgoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE


(Plasmodium
falciparum)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
5 LEU C 135
VAL C  76
ASP C 151
ILE C  28
VAL C 132
None
1.43A 2l8mA-5fmgC:
undetectable
2l8mA-5fmgC:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA


(Homo sapiens)
PF00102
(Y_phosphatase)
5 LEU A1946
VAL A1915
VAL A1931
ILE A1826
VAL A1824
7WL  A2101 (-4.7A)
None
None
7WL  A2101 (-3.9A)
None
1.30A 2l8mA-5h08A:
undetectable
2l8mA-5h08A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN


(uncultured
marine
bacterium)
PF03480
(DctP)
5 TYR A 137
VAL A  89
VAL A  85
ASP A  83
VAL A  86
None
1.00A 2l8mA-5i5pA:
undetectable
2l8mA-5i5pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans)
no annotation 5 LEU B 309
VAL B 305
THR B 418
ASP B 344
ILE B 347
None
1.25A 2l8mA-5khnB:
undetectable
2l8mA-5khnB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1


(Mus musculus)
PF00054
(Laminin_G_1)
PF06009
(Laminin_II)
5 THR A2343
LEU A2366
VAL A2371
THR A2386
VAL A2411
None
1.35A 2l8mA-5mc9A:
undetectable
2l8mA-5mc9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmx CSPYL1_ABA

(Citrus sinensis)
no annotation 5 LEU B 197
VAL B 168
THR B 153
ILE B  77
VAL B  78
None
1.23A 2l8mA-5mmxB:
undetectable
2l8mA-5mmxB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3


(Homo sapiens)
PF02469
(Fasciclin)
5 VAL A 113
THR A 109
VAL A 228
ASP A 221
VAL A 229
None
1.36A 2l8mA-5nv6A:
undetectable
2l8mA-5nv6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3u PTS SYSTEM, IIA
COMPONENT


(Streptococcus
pneumoniae)
PF03610
(EIIA-man)
5 LEU A  63
VAL A  59
ASP A  95
ILE A  96
VAL A  71
None
1.43A 2l8mA-5t3uA:
undetectable
2l8mA-5t3uA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqp CUPIN

(Rhodococcus
jostii)
PF07883
(Cupin_2)
5 LEU A  80
VAL A  89
VAL A  54
ILE A 115
VAL A 113
None
1.16A 2l8mA-5uqpA:
undetectable
2l8mA-5uqpA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vft PROTEASOME SUBUNIT
BETA TYPE-4


(Homo sapiens)
no annotation 5 LEU T 150
VAL T 169
VAL T  20
ILE T  22
VAL T  21
None
1.33A 2l8mA-5vftT:
undetectable
2l8mA-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vh6 ELONGATION FACTOR G

(Bacillus
subtilis)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
5 THR A  34
LEU A 271
VAL A 270
ILE A  15
VAL A 103
None
1.15A 2l8mA-5vh6A:
undetectable
2l8mA-5vh6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum)
no annotation 5 VAL A 218
THR A 216
VAL A 132
ASP A 134
VAL A 141
None
1.03A 2l8mA-5xqoA:
undetectable
2l8mA-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu0 MEMBRANE-FUSION
PROTEIN


(Streptococcus
pneumoniae)
no annotation 5 LEU A  87
VAL A  88
VAL A  74
ILE A 228
VAL A 226
None
1.48A 2l8mA-5xu0A:
undetectable
2l8mA-5xu0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br8 PROTEIN A6 HOMOLOG

(Fowlpox virus)
no annotation 5 VAL A 341
THR A 345
VAL A 357
ASP A 358
ILE A 362
6OU  A 401 ( 4.3A)
6OU  A 401 (-4.7A)
6OU  A 401 ( 4.9A)
None
PGV  A 404 ( 4.1A)
1.46A 2l8mA-6br8A:
undetectable
2l8mA-6br8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN


(Streptococcus
pneumoniae)
no annotation 5 THR A 317
LEU A 377
THR A 394
ILE A 330
VAL A 398
None
1.34A 2l8mA-6ewjA:
undetectable
2l8mA-6ewjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB


(Thermotoga
maritima)
no annotation 5 LEU A  50
VAL A  57
ASP A  56
ILE A  86
VAL A  58
None
1.39A 2l8mA-6fpeA:
undetectable
2l8mA-6fpeA:
undetectable