SIMILAR PATTERNS OF AMINO ACIDS FOR 2L8M_A_CAMA415_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cjy | PROTEIN (CYTOSOLICPHOSPHOLIPASE A2) (Homo sapiens) |
PF00168(C2)PF01735(PLA2_B) | 5 | THR A 128LEU A 91VAL A 46THR A 60VAL A 24 | None | 1.31A | 2l8mA-1cjyA:0.0 | 2l8mA-1cjyA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e2y | TRYPAREDOXINPEROXIDASE (Crithidiafasciculata) |
PF00578(AhpC-TSA)PF10417(1-cysPrx_C) | 5 | VAL A 40VAL A 153ASP A 62ILE A 157VAL A 156 | None | 1.32A | 2l8mA-1e2yA:0.0 | 2l8mA-1e2yA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f2j | FRUCTOSE-BISPHOSPHATE ALDOLASE,GLYCOSOMAL (Trypanosomabrucei) |
PF00274(Glycolytic) | 5 | THR A 278LEU A 237VAL A 193THR A 28VAL A 112 | None | 1.38A | 2l8mA-1f2jA:0.0 | 2l8mA-1f2jA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fl2 | ALKYL HYDROPEROXIDEREDUCTASE SUBUNIT F (Escherichiacoli) |
PF07992(Pyr_redox_2) | 5 | THR A 322VAL A 462THR A 478ILE A 318VAL A 483 | FAD A 522 (-4.1A)NoneNoneNoneNone | 1.29A | 2l8mA-1fl2A:0.0 | 2l8mA-1fl2A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iok | CHAPERONIN 60 (Paracoccusdenitrificans) |
PF00118(Cpn60_TCP1) | 5 | THR A 91LEU A 95THR A 124ILE A 131VAL A 128 | None | 1.50A | 2l8mA-1iokA:0.0 | 2l8mA-1iokA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l9w | 3-DEHYDROQUINATEDEHYDRATASE AROD (Salmonellaenterica) |
PF01487(DHquinase_I) | 5 | TYR A 97VAL A 139ASP A 114ILE A 113VAL A 138 | None | 1.45A | 2l8mA-1l9wA:0.0 | 2l8mA-1l9wA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o70 | FASCICLIN I (Drosophilamelanogaster) |
PF02469(Fasciclin) | 5 | THR A 504LEU A 568VAL A 566ILE A 588VAL A 579 | None | 1.49A | 2l8mA-1o70A:0.0 | 2l8mA-1o70A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o73 | TRYPAREDOXIN (Trypanosomabrucei) |
PF13905(Thioredoxin_8) | 5 | THR A 96LEU A 89VAL A 66ILE A 115VAL A 31 | None | 1.43A | 2l8mA-1o73A:0.0 | 2l8mA-1o73A:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1twd | COPPER HOMEOSTASISPROTEIN CUTC (Shigellaflexneri) |
PF03932(CutC) | 5 | LEU A 95VAL A 101THR A 133VAL A 145ILE A 142 | None | 1.42A | 2l8mA-1twdA:0.0 | 2l8mA-1twdA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ur4 | GALACTANASE (Bacilluslicheniformis) |
PF07745(Glyco_hydro_53) | 5 | VAL A 261THR A 264VAL A 300ILE A 304VAL A 303 | None | 1.38A | 2l8mA-1ur4A:undetectable | 2l8mA-1ur4A:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uwv | 23S RRNA(URACIL-5-)-METHYLTRANSFERASE RUMA (Escherichiacoli) |
PF01938(TRAM)PF05958(tRNA_U5-meth_tr) | 5 | LEU A 279VAL A 284VAL A 311ASP A 292VAL A 290 | None | 1.33A | 2l8mA-1uwvA:undetectable | 2l8mA-1uwvA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vq7 | 50S RIBOSOMALPROTEIN L30P (Haloarculamarismortui) |
PF00327(Ribosomal_L30) | 5 | LEU W 100THR W 88VAL W 79ILE W 93VAL W 84 | None | 1.32A | 2l8mA-1vq7W:undetectable | 2l8mA-1vq7W:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3w | PEPTIDE:N-GLYCANASE (Saccharomycescerevisiae) |
PF03835(Rad4) | 5 | THR A 297VAL A 267ASP A 268ILE A 259VAL A 266 | None | 1.49A | 2l8mA-1x3wA:undetectable | 2l8mA-1x3wA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y11 | HYPOTHETICAL PROTEINRV1264/MT1302 (Mycobacteriumtuberculosis) |
PF00211(Guanylate_cyc)PF16701(Ad_Cy_reg) | 5 | THR A 217LEU A 277VAL A 281VAL A 374VAL A 333 | None | 1.38A | 2l8mA-1y11A:undetectable | 2l8mA-1y11A:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1u | SIGNAL TRANSDUCERAND ACTIVATOR OFTRANSCRIPTION 5A (Mus musculus) |
PF00017(SH2)PF01017(STAT_alpha)PF02864(STAT_bind) | 5 | THR A 481VAL A 341ASP A 475ILE A 469VAL A 467 | None | 1.47A | 2l8mA-1y1uA:undetectable | 2l8mA-1y1uA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yf2 | TYPE IRESTRICTION-MODIFICATION ENZYME, SSUBUNIT (Methanocaldococcusjannaschii) |
PF01420(Methylase_S) | 5 | THR A 111LEU A 92VAL A 91VAL A 158ILE A 32 | None | 1.46A | 2l8mA-1yf2A:undetectable | 2l8mA-1yf2A:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5j | RAS-RELATED PROTEINRAB-2B (Homo sapiens) |
PF00071(Ras) | 5 | THR A 168VAL A 161THR A 153VAL A 90ILE A 16 | None | 1.34A | 2l8mA-2a5jA:undetectable | 2l8mA-2a5jA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5j | RAS-RELATED PROTEINRAB-2B (Homo sapiens) |
PF00071(Ras) | 5 | TYR A 14THR A 168THR A 153VAL A 90ILE A 16 | None | 1.36A | 2l8mA-2a5jA:undetectable | 2l8mA-2a5jA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0x | GAMMA-GLUTAMYLTRANSPEPTIDASEGAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli;Escherichiacoli) |
PF01019(G_glu_transpept)PF01019(G_glu_transpept) | 5 | VAL A 287VAL B 496ASP B 500ILE B 499VAL B 495 | None | 1.32A | 2l8mA-2e0xA:undetectable | 2l8mA-2e0xA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e6k | TRANSKETOLASE (Thermusthermophilus) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | LEU A 597VAL A 599VAL A 535ASP A 538VAL A 573 | None | 1.28A | 2l8mA-2e6kA:undetectable | 2l8mA-2e6kA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7u | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Thermusthermophilus) |
PF00202(Aminotran_3) | 5 | TYR A 57THR A 416LEU A 387VAL A 350ILE A 357 | None | 1.17A | 2l8mA-2e7uA:undetectable | 2l8mA-2e7uA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eeo | ASPARTATE1-DECARBOXYLASEASPARTATE1-DECARBOXYLASE (Thermusthermophilus;Thermusthermophilus) |
PF02261(Asp_decarbox)PF02261(Asp_decarbox) | 5 | THR B 57LEU B 55VAL B 79ILE B 69VAL A 15 | FUM B 501 ( 3.6A)NoneNoneNoneNone | 1.46A | 2l8mA-2eeoB:undetectable | 2l8mA-2eeoB:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6h | MYOSIN-2 (Saccharomycescerevisiae) |
PF01843(DIL) | 5 | THR X 312LEU X 283VAL X 196VAL X 260ASP X 261 | None | 1.44A | 2l8mA-2f6hX:undetectable | 2l8mA-2f6hX:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gax | HYPOTHETICAL PROTEINATU0240 (Agrobacteriumfabrum) |
PF09391(DUF2000) | 5 | LEU A 14THR A 23VAL A 60ILE A 9VAL A 8 | None | 1.35A | 2l8mA-2gaxA:undetectable | 2l8mA-2gaxA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gki | NUCLEASE (Mus musculus) |
PF07686(V-set) | 5 | THR A 266LEU A 169VAL A 171ILE A 239VAL A 242 | None | 1.46A | 2l8mA-2gkiA:undetectable | 2l8mA-2gkiA:21.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 7 | THR A 101LEU A 244THR A 252VAL A 295ASP A 297ILE A 395VAL A 396 | HEM A 501 (-2.9A)HEM A 501 (-4.5A)HEM A 501 (-3.4A)HEM A 501 (-4.6A)HEM A 501 (-2.8A)NoneNone | 0.92A | 2l8mA-2m56A:58.8 | 2l8mA-2m56A:99.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 7 | THR A 101LEU A 244VAL A 247THR A 252VAL A 295ASP A 297ILE A 395 | HEM A 501 (-2.9A)HEM A 501 (-4.5A)NoneHEM A 501 (-3.4A)HEM A 501 (-4.6A)HEM A 501 (-2.8A)None | 0.95A | 2l8mA-2m56A:58.8 | 2l8mA-2m56A:99.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 7 | TYR A 96THR A 101LEU A 244THR A 252VAL A 295ILE A 395VAL A 396 | CAM A 502 (-4.5A)HEM A 501 (-2.9A)HEM A 501 (-4.5A)HEM A 501 (-3.4A)HEM A 501 (-4.6A)NoneNone | 0.79A | 2l8mA-2m56A:58.8 | 2l8mA-2m56A:99.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 7 | TYR A 96THR A 101LEU A 244VAL A 247THR A 252VAL A 295ILE A 395 | CAM A 502 (-4.5A)HEM A 501 (-2.9A)HEM A 501 (-4.5A)NoneHEM A 501 (-3.4A)HEM A 501 (-4.6A)None | 0.84A | 2l8mA-2m56A:58.8 | 2l8mA-2m56A:99.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 7 | TYR A 96THR A 101LEU A 244VAL A 247THR A 252VAL A 396ILE A 395 | CAM A 502 (-4.5A)HEM A 501 (-2.9A)HEM A 501 (-4.5A)NoneHEM A 501 (-3.4A)NoneNone | 1.43A | 2l8mA-2m56A:58.8 | 2l8mA-2m56A:99.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w6r | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASESUBUNIT HISF (Thermotogamaritima) |
PF00977(His_biosynth) | 5 | VAL A 195THR A 199VAL A 165ILE A 134VAL A 162 | None | 1.42A | 2l8mA-2w6rA:undetectable | 2l8mA-2w6rA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wae | PENICILLIN-BINDINGPROTEIN 2B (Streptococcuspneumoniae) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | TYR A 176VAL A 104VAL A 79ILE A 192VAL A 80 | None | 1.12A | 2l8mA-2waeA:undetectable | 2l8mA-2waeA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wjf | TYROSINE-PROTEINPHOSPHATASE CPSB (Streptococcuspneumoniae) |
no annotation | 5 | THR A 40LEU A 106VAL A 133ASP A 3VAL A 195 | None | 1.21A | 2l8mA-2wjfA:undetectable | 2l8mA-2wjfA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z0m | 337AA LONGHYPOTHETICALATP-DEPENDENT RNAHELICASE DEAD (Sulfurisphaeratokodaii) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | LEU A 60VAL A 61THR A 63ILE A 76VAL A 72 | None | 1.39A | 2l8mA-2z0mA:undetectable | 2l8mA-2z0mA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsk | 226AA LONGHYPOTHETICALASPARTATE RACEMASE (Pyrococcushorikoshii) |
PF01177(Asp_Glu_race) | 5 | LEU A 111VAL A 115VAL A 143ILE A 190VAL A 118 | None | 1.32A | 2l8mA-2zskA:undetectable | 2l8mA-2zskA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c19 | UNCHARACTERIZEDPROTEIN MK0293 (Methanopyruskandleri) |
PF01969(DUF111) | 5 | THR A 145LEU A 168VAL A 166VAL A 116VAL A 105 | None | 1.28A | 2l8mA-3c19A:undetectable | 2l8mA-3c19A:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c24 | PUTATIVEOXIDOREDUCTASE (Jannaschia sp.CCS1) |
PF03807(F420_oxidored)PF16896(PGDH_C) | 5 | VAL A 70THR A 94ASP A 65ILE A 64VAL A 90 | NoneGOL A 288 (-3.2A)NoneNoneNone | 1.50A | 2l8mA-3c24A:undetectable | 2l8mA-3c24A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ch7 | 6-PHOSPHOGLUCONOLACTONASE (Leishmaniabraziliensis) |
PF01182(Glucosamine_iso) | 5 | TYR A 53LEU A 218VAL A 216ILE A 25VAL A 24 | None | 1.46A | 2l8mA-3ch7A:undetectable | 2l8mA-3ch7A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cje | OSMC-LIKE PROTEIN (Jannaschia sp.CCS1) |
PF02566(OsmC) | 5 | VAL A 73THR A 70ASP A 118ILE A 119VAL A 93 | None | 1.40A | 2l8mA-3cjeA:undetectable | 2l8mA-3cjeA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6k | PUTATIVEAMINOTRANSFERASE (Corynebacteriumdiphtheriae) |
PF12897(Aminotran_MocR) | 5 | LEU A 363VAL A 360THR A 356VAL A 336VAL A 352 | None | 1.33A | 2l8mA-3d6kA:undetectable | 2l8mA-3d6kA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dx5 | UNCHARACTERIZEDPROTEIN ASBF (Bacillusanthracis) |
PF01261(AP_endonuc_2) | 5 | TYR A 121LEU A 158VAL A 162VAL A 139ILE A 128 | None | 1.45A | 2l8mA-3dx5A:undetectable | 2l8mA-3dx5A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3elu | METHYLTRANSFERASE (Wesselsbronvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 5 | THR A 236VAL A 183THR A 161ILE A 192VAL A 191 | None | 1.07A | 2l8mA-3eluA:undetectable | 2l8mA-3eluA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emv | URIDINEPHOSPHORYLASE,PUTATIVE (Plasmodiumvivax) |
PF01048(PNP_UDP_1) | 5 | LEU A 139VAL A 135VAL A 19ILE A 87VAL A 86 | None | 1.19A | 2l8mA-3emvA:undetectable | 2l8mA-3emvA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbg | PUTATIVE ARGINATELYASE (Staphylococcushaemolyticus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | VAL A 121THR A 303VAL A 306ILE A 333VAL A 332 | None | 1.39A | 2l8mA-3fbgA:undetectable | 2l8mA-3fbgA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdo | UNCHARACTERIZEDOXIDOREDUCTASE YVAA (Bacillussubtilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | TYR A 313THR A 90VAL A 77ILE A 78VAL A 79 | None | 1.34A | 2l8mA-3gdoA:undetectable | 2l8mA-3gdoA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3go4 | PROTEIN OF UNKNOWNFUNCTION DUF574 (Streptomycesavermitilis) |
PF04672(Methyltransf_19) | 5 | LEU A 185VAL A 182VAL A 172ILE A 168VAL A 169 | NoneNoneNoneSAH A 277 (-4.0A)None | 1.35A | 2l8mA-3go4A:undetectable | 2l8mA-3go4A:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hid | ADENYLOSUCCINATESYNTHETASE (Yersinia pestis) |
PF00709(Adenylsucc_synt) | 5 | TYR A 399VAL A 267THR A 10ILE A 313VAL A 316 | None | 1.41A | 2l8mA-3hidA:undetectable | 2l8mA-3hidA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js8 | CHOLESTEROL OXIDASE (Chromobacteriumsp. DS-1) |
PF01565(FAD_binding_4)PF09129(Chol_subst-bind) | 5 | LEU A 374VAL A 370THR A 365ILE A 148VAL A 437 | None | 1.45A | 2l8mA-3js8A:undetectable | 2l8mA-3js8A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lz8 | PUTATIVE CHAPERONEDNAJ (Klebsiellapneumoniae) |
PF01556(DnaJ_C) | 5 | THR A 130VAL A 168ASP A 169ILE A 195VAL A 167 | None | 1.44A | 2l8mA-3lz8A:undetectable | 2l8mA-3lz8A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tco | THIOREDOXIN (TRXA-1) (Sulfolobussolfataricus) |
PF00085(Thioredoxin) | 5 | TYR A 95LEU A 83ASP A 39ILE A 42VAL A 41 | None | 1.25A | 2l8mA-3tcoA:undetectable | 2l8mA-3tcoA:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tmc | UNCHARACTERIZEDPROTEIN (Bdellovibriobacteriovorus) |
PF13487(HD_5) | 5 | THR A 272VAL A 152THR A 156ILE A 140VAL A 137 | DMS A 312 (-4.3A)NoneNoneNoneNone | 1.20A | 2l8mA-3tmcA:undetectable | 2l8mA-3tmcA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uc0 | ENVELOPE PROTEIN (Dengue virus) |
PF00869(Flavi_glycoprot) | 5 | LEU A 25VAL A 31THR A 33VAL A 21ASP A 22 | None | 1.38A | 2l8mA-3uc0A:undetectable | 2l8mA-3uc0A:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aut | DECAPRENYL-PHOSPHORYL-BETA-D-RIBOFURANOSE-2-OXIDOREDUCTASE (Mycolicibacteriumsmegmatis) |
PF01565(FAD_binding_4)PF04030(ALO) | 5 | LEU A 158VAL A 165VAL A 47ILE A 43VAL A 44 | None | 1.00A | 2l8mA-4autA:undetectable | 2l8mA-4autA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bzi | SEC23P (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 5 | TYR A 329THR A 262LEU A 286VAL A 343VAL A 336 | None | 1.48A | 2l8mA-4bziA:undetectable | 2l8mA-4bziA:20.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 7 | THR A 103LEU A 252THR A 260VAL A 303ASP A 305ILE A 403VAL A 404 | GOL A1419 (-3.8A)HEM A1418 (-4.0A)HEM A1418 (-3.6A)GOL A1419 (-3.9A)HEM A1418 (-2.7A)NoneGOL A1419 (-3.5A) | 0.94A | 2l8mA-4c9mA:53.4 | 2l8mA-4c9mA:45.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 7 | TYR A 98THR A 103LEU A 252THR A 260VAL A 303ILE A 403VAL A 404 | NoneGOL A1419 (-3.8A)HEM A1418 (-4.0A)HEM A1418 (-3.6A)GOL A1419 (-3.9A)NoneGOL A1419 (-3.5A) | 0.86A | 2l8mA-4c9mA:53.4 | 2l8mA-4c9mA:45.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ciu | CHAPERONE PROTEINCLPB (Escherichiacoli) |
PF00004(AAA)PF07724(AAA_2)PF10431(ClpB_D2-small) | 5 | LEU A 566VAL A 580VAL A 673ILE A 715VAL A 713 | None | 1.37A | 2l8mA-4ciuA:undetectable | 2l8mA-4ciuA:21.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | THR A 101THR A 258VAL A 301ILE A 401VAL A 402 | HEM A 501 ( 4.8A)HEM A 501 (-3.7A)PEG A 502 ( 4.5A)NoneNone | 0.67A | 2l8mA-4dxyA:48.5 | 2l8mA-4dxyA:46.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evz | HISF-LUCA (syntheticconstruct) |
PF00977(His_biosynth) | 5 | VAL A 107THR A 149ASP A 130ILE A 129VAL A 140 | None | 1.44A | 2l8mA-4evzA:undetectable | 2l8mA-4evzA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ffy | DENV1-E111 SINGLECHAIN VARIABLEFRAGMENT (LIGHTCHAIN) (Mus musculus) |
PF07686(V-set) | 5 | THR L 102LEU L 11VAL L 13ILE L 75VAL L 78 | None | 1.46A | 2l8mA-4ffyL:undetectable | 2l8mA-4ffyL:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hnr | CHEMOTAXIS PROTEINCHEY (Vibrio cholerae) |
PF00072(Response_reg) | 5 | TYR A 26LEU A 119VAL A 118THR A 99ILE A 50 | None | 1.47A | 2l8mA-4hnrA:undetectable | 2l8mA-4hnrA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iys | METAL TRANSPORTERCNNM2 (Homo sapiens) |
PF00571(CBS) | 5 | THR A 469LEU A 465THR A 515VAL A 483ILE A 481 | None | 1.24A | 2l8mA-4iysA:undetectable | 2l8mA-4iysA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0m | SERINE/THREONINE-PROTEIN KINASEBRI1-LIKE 1 (Arabidopsisthaliana) |
PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 5 | TYR A 140VAL A 146VAL A 180ILE A 158VAL A 156 | None | 1.38A | 2l8mA-4j0mA:undetectable | 2l8mA-4j0mA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcc | IRON-COMPOUND ABCTRANSPORTER,IRON-COMPOUND-BINDING PROTEIN (Streptococcuspneumoniae) |
PF01497(Peripla_BP_2) | 5 | LEU A 65VAL A 88THR A 85VAL A 99VAL A 96 | NoneNoneSO4 A 404 ( 4.7A)NoneNone | 1.38A | 2l8mA-4jccA:undetectable | 2l8mA-4jccA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4js5 | EXODEOXYRIBONUCLEASEI (Escherichiacoli) |
PF00929(RNase_T)PF08411(Exonuc_X-T_C) | 5 | TYR A 284VAL A 298VAL A 348ILE A 350VAL A 347 | None | 1.22A | 2l8mA-4js5A:undetectable | 2l8mA-4js5A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k46 | ADENYLATE KINASE (Photobacteriumprofundum) |
PF00406(ADK)PF05191(ADK_lid) | 5 | TYR A 171THR A 199ASP A 113ILE A 116VAL A 115 | None | 1.39A | 2l8mA-4k46A:undetectable | 2l8mA-4k46A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6m | POLYPROTEIN (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 5 | THR A 236VAL A 183THR A 161ILE A 192VAL A 191 | None | 1.10A | 2l8mA-4k6mA:undetectable | 2l8mA-4k6mA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mdy | PERIPLASMIC BINDINGPROTEIN (Mycolicibacteriumsmegmatis) |
PF01497(Peripla_BP_2) | 5 | THR A 125VAL A 55VAL A 69ASP A 65VAL A 71 | None | 1.38A | 2l8mA-4mdyA:undetectable | 2l8mA-4mdyA:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mq3 | INTEGRASE (Felineimmunodeficiencyvirus) |
PF00665(rve) | 5 | THR A 99LEU A 76VAL A 77ASP A 118VAL A 153 | None | 1.35A | 2l8mA-4mq3A:undetectable | 2l8mA-4mq3A:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nes | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Methanocaldococcusjannaschii) |
PF02350(Epimerase_2) | 5 | THR A 71LEU A 75VAL A 105VAL A 92ILE A 6 | None | 1.30A | 2l8mA-4nesA:undetectable | 2l8mA-4nesA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nk7 | SERINE/THREONINE-PROTEIN KINASE PLK4 (Drosophilamelanogaster) |
no annotation | 5 | LEU A 409VAL A 414THR A 391VAL A 495VAL A 492 | None | 1.49A | 2l8mA-4nk7A:undetectable | 2l8mA-4nk7A:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r4n | HIV-1 GP120 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | THR A 387LEU A 416VAL A 333ILE A 449VAL A 292 | None | 1.38A | 2l8mA-4r4nA:undetectable | 2l8mA-4r4nA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwr | STAGE II SPORULATIONPROTEIN D (Bacillusanthracis) |
PF08486(SpoIID) | 5 | THR A 288LEU A 270VAL A 264ILE A 240VAL A 252 | None | 1.46A | 2l8mA-4rwrA:undetectable | 2l8mA-4rwrA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rx4 | HIV-1 CLADE AQ842.D12 GP120 (Humanimmunodeficiencyvirus 1) |
no annotation | 5 | THR G 387LEU G 416VAL G 333ILE G 449VAL G 292 | None | 1.49A | 2l8mA-4rx4G:undetectable | 2l8mA-4rx4G:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1j | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Leishmaniadonovani) |
PF00160(Pro_isomerase) | 5 | LEU A 40VAL A 179THR A 167ILE A 85VAL A 79 | None | 1.39A | 2l8mA-4s1jA:undetectable | 2l8mA-4s1jA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqt | D-HYDANTOINASE (Brucella suis) |
PF01979(Amidohydro_1) | 5 | VAL A 15THR A 17VAL A 387ILE A 33VAL A 386 | None | 1.40A | 2l8mA-4tqtA:undetectable | 2l8mA-4tqtA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uwq | SULFUR OXIDATIONPROTEIN SOXB (Thermusthermophilus) |
PF02872(5_nucleotid_C) | 5 | TYR A 518THR A 436LEU A 541VAL A 400ASP A 393 | None | 1.44A | 2l8mA-4uwqA:undetectable | 2l8mA-4uwqA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7s | PRE-MRNA-SPLICINGATP-DEPENDENT RNAHELICASE PRP28 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | LEU A 192VAL A 277THR A 274ILE A 233VAL A 232 | None | 1.48A | 2l8mA-4w7sA:undetectable | 2l8mA-4w7sA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvg | ALKYL HYDROPEROXIDEREDUCTASE SUBUNIT F (Escherichiacoli) |
PF07992(Pyr_redox_2)PF13192(Thioredoxin_3) | 5 | THR A 322VAL A 462THR A 478ILE A 318VAL A 483 | FAD A 700 (-4.0A)NoneNoneNoneNone | 1.31A | 2l8mA-4xvgA:undetectable | 2l8mA-4xvgA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydi | ENVELOPEGLYCOPROTEIN GP160 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | THR G 387LEU G 416VAL G 333ILE G 449VAL G 292 | None | 1.40A | 2l8mA-4ydiG:undetectable | 2l8mA-4ydiG:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgs | PUTATIVE D-LACTATEDEHYDROGENASE (Chlamydomonasreinhardtii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 228VAL A 183THR A 186ILE A 220VAL A 215 | None | 1.48A | 2l8mA-4zgsA:undetectable | 2l8mA-4zgsA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zpm | PROTEIN PCDHAC2 (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 5 | THR A 219LEU A 310VAL A 311VAL A 275VAL A 234 | None | 1.43A | 2l8mA-4zpmA:undetectable | 2l8mA-4zpmA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dd5 | ANTI-HIV ANTIBODYDH570.9 FAB HEAVYCHAIN (Macaca mulatta) |
PF07654(C1-set)PF07686(V-set) | 5 | THR H 67LEU H 80VAL H 20ASP H 86VAL H 109 | None | 1.22A | 2l8mA-5dd5H:undetectable | 2l8mA-5dd5H:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dgo | CELL DIVISIONCONTROL PROTEIN 45HOMOLOG (Homo sapiens) |
PF02724(CDC45) | 5 | VAL A 229THR A 225VAL A 376ASP A 375VAL A 377 | EDO A 602 ( 4.9A)NoneEDO A 601 (-3.6A)NoneNone | 1.35A | 2l8mA-5dgoA:undetectable | 2l8mA-5dgoA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITALPHA TYPE (Plasmodiumfalciparum) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 5 | LEU C 135VAL C 76ASP C 151ILE C 28VAL C 132 | None | 1.43A | 2l8mA-5fmgC:undetectable | 2l8mA-5fmgC:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h08 | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE ZETA (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | LEU A1946VAL A1915VAL A1931ILE A1826VAL A1824 | 7WL A2101 (-4.7A)NoneNone7WL A2101 (-3.9A)None | 1.30A | 2l8mA-5h08A:undetectable | 2l8mA-5h08A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i5p | TRAP TRANSPORTERSOLUTE BINDINGPROTEIN (unculturedmarinebacterium) |
PF03480(DctP) | 5 | TYR A 137VAL A 89VAL A 85ASP A 83VAL A 86 | None | 1.00A | 2l8mA-5i5pA:undetectable | 2l8mA-5i5pA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5khn | RND TRANSPORTER (Burkholderiamultivorans) |
no annotation | 5 | LEU B 309VAL B 305THR B 418ASP B 344ILE B 347 | None | 1.25A | 2l8mA-5khnB:undetectable | 2l8mA-5khnB:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mc9 | LAMININ SUBUNITALPHA-1 (Mus musculus) |
PF00054(Laminin_G_1)PF06009(Laminin_II) | 5 | THR A2343LEU A2366VAL A2371THR A2386VAL A2411 | None | 1.35A | 2l8mA-5mc9A:undetectable | 2l8mA-5mc9A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mmx | CSPYL1_ABA (Citrus sinensis) |
no annotation | 5 | LEU B 197VAL B 168THR B 153ILE B 77VAL B 78 | None | 1.23A | 2l8mA-5mmxB:undetectable | 2l8mA-5mmxB:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nv6 | TRANSFORMING GROWTHFACTOR-BETA-INDUCEDPROTEIN IG-H3 (Homo sapiens) |
PF02469(Fasciclin) | 5 | VAL A 113THR A 109VAL A 228ASP A 221VAL A 229 | None | 1.36A | 2l8mA-5nv6A:undetectable | 2l8mA-5nv6A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t3u | PTS SYSTEM, IIACOMPONENT (Streptococcuspneumoniae) |
PF03610(EIIA-man) | 5 | LEU A 63VAL A 59ASP A 95ILE A 96VAL A 71 | None | 1.43A | 2l8mA-5t3uA:undetectable | 2l8mA-5t3uA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqp | CUPIN (Rhodococcusjostii) |
PF07883(Cupin_2) | 5 | LEU A 80VAL A 89VAL A 54ILE A 115VAL A 113 | None | 1.16A | 2l8mA-5uqpA:undetectable | 2l8mA-5uqpA:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vft | PROTEASOME SUBUNITBETA TYPE-4 (Homo sapiens) |
no annotation | 5 | LEU T 150VAL T 169VAL T 20ILE T 22VAL T 21 | None | 1.33A | 2l8mA-5vftT:undetectable | 2l8mA-5vftT:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vh6 | ELONGATION FACTOR G (Bacillussubtilis) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2) | 5 | THR A 34LEU A 271VAL A 270ILE A 15VAL A 103 | None | 1.15A | 2l8mA-5vh6A:undetectable | 2l8mA-5vh6A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xqo | PCRGLX PROTEIN (Penicilliumchrysogenum) |
no annotation | 5 | VAL A 218THR A 216VAL A 132ASP A 134VAL A 141 | None | 1.03A | 2l8mA-5xqoA:undetectable | 2l8mA-5xqoA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xu0 | MEMBRANE-FUSIONPROTEIN (Streptococcuspneumoniae) |
no annotation | 5 | LEU A 87VAL A 88VAL A 74ILE A 228VAL A 226 | None | 1.48A | 2l8mA-5xu0A:undetectable | 2l8mA-5xu0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6br8 | PROTEIN A6 HOMOLOG (Fowlpox virus) |
no annotation | 5 | VAL A 341THR A 345VAL A 357ASP A 358ILE A 362 | 6OU A 401 ( 4.3A)6OU A 401 (-4.7A)6OU A 401 ( 4.9A)NonePGV A 404 ( 4.1A) | 1.46A | 2l8mA-6br8A:undetectable | 2l8mA-6br8A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ewj | PUTATIVE CAPSULARPOLYSACCHARIDEBIOSYNTHESIS PROTEIN (Streptococcuspneumoniae) |
no annotation | 5 | THR A 317LEU A 377THR A 394ILE A 330VAL A 398 | None | 1.34A | 2l8mA-6ewjA:undetectable | 2l8mA-6ewjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fpe | TRNATHREONYLCARBAMOYLADENOSINE BIOSYNTHESISPROTEIN TSAB (Thermotogamaritima) |
no annotation | 5 | LEU A 50VAL A 57ASP A 56ILE A 86VAL A 58 | None | 1.39A | 2l8mA-6fpeA:undetectable | 2l8mA-6fpeA:undetectable |