SIMILAR PATTERNS OF AMINO ACIDS FOR 2KUH_A_HLTA150

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 418
MET A 417
LEU A 273
GLU A 265
 None
 1.28A 2kuhA-1b8aA:
0.0		 2kuhA-1b8aA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 LEU A 295
MET A 207
LEU A 288
MET A  38
 None
 0.96A 2kuhA-1d2fA:
0.6		 2kuhA-1d2fA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		4 LEU A  44
MET A 270
LEU A 266
GLU A  39
 None
 1.26A 2kuhA-1e2tA:
0.0		 2kuhA-1e2tA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		4 LEU A  26
MET A   9
LEU A  40
GLU A  24
 None
 1.22A 2kuhA-1j31A:
undetectable		 2kuhA-1j31A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j83 ENDO-1,4-BETA
GLUCANASE ENGF

(Clostridium
cellulovorans) 		PF03424
(CBM_17_28) 		4 LEU A1110
MET A1112
LEU A1161
MET A1186
 None
 1.25A 2kuhA-1j83A:
undetectable		 2kuhA-1j83A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jos RIBOSOME-BINDING
FACTOR A

(Haemophilus
influenzae) 		PF02033
(RBFA) 		4 LEU A  88
LEU A  82
MET A  86
GLU A  14
 None
 1.03A 2kuhA-1josA:
undetectable		 2kuhA-1josA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 447
LEU A 491
MET A 448
GLU A 445
 None
 1.28A 2kuhA-1lxtA:
0.0		 2kuhA-1lxtA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP) 		4 LEU A 428
LEU A 339
GLU A 332
MET A 310
 None
 1.11A 2kuhA-1o7fA:
1.2		 2kuhA-1o7fA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		4 LEU A  87
LEU A 100
MET A 130
GLU A 131
 None
 1.29A 2kuhA-1oy5A:
undetectable		 2kuhA-1oy5A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 LEU A 127
LEU A  65
MET A 123
MET A 110
 None
 1.29A 2kuhA-1pw4A:
undetectable		 2kuhA-1pw4A:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 LEU A 147
MET A 129
LEU A 131
GLU A 114
 None
 1.21A 2kuhA-1r30A:
undetectable		 2kuhA-1r30A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shk SHIKIMATE KINASE

(Dickeya
chrysanthemi) 		PF01202
(SKI) 		4 LEU A 164
MET A 168
LEU A 170
MET A   7
 None
 0.94A 2kuhA-1shkA:
undetectable		 2kuhA-1shkA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B 385
MET B 302
LEU B 315
GLU B 383
 None
 1.17A 2kuhA-1t3qB:
undetectable		 2kuhA-1t3qB:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		4 LEU A  39
MET A  90
LEU A  37
GLU A  59
 None
 1.15A 2kuhA-1v4vA:
0.0		 2kuhA-1v4vA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A 203
LEU A 261
MET A 235
GLU A 234
 None
 1.29A 2kuhA-1wpqA:
0.0		 2kuhA-1wpqA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Chromobacterium
violaceum) 		PF04952
(AstE_AspA) 		4 LEU A 131
MET A  87
LEU A  50
GLU A 129
 None
 1.20A 2kuhA-1yw4A:
undetectable		 2kuhA-1yw4A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  63
MET H  82
LEU H  80
MET H  48
 None
 1.02A 2kuhA-1zanH:
undetectable		 2kuhA-1zanH:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  80
MET H  48
LEU H  63
MET H  82
 None
 1.10A 2kuhA-1zanH:
undetectable		 2kuhA-1zanH:
12.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LEU B 105
MET B 109
LEU B 116
MET B 124
 None
 1.10A 2kuhA-1zotB:
7.8		 2kuhA-1zotB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8v RNA BINDING DOMAIN
OF RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		4 LEU A  17
MET A  21
LEU A  23
MET A   1
 None
 0.84A 2kuhA-2a8vA:
undetectable		 2kuhA-2a8vA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 LEU A  19
MET A  43
LEU A  83
MET A  73
 None
 1.17A 2kuhA-2avfA:
undetectable		 2kuhA-2avfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db0 253AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF02985
(HEAT) 		4 LEU A  74
MET A  70
LEU A  41
GLU A  89
 None
 0.80A 2kuhA-2db0A:
undetectable		 2kuhA-2db0A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X 142
MET X 110
LEU X 107
GLU X  98
 None
 1.21A 2kuhA-2dq7X:
undetectable		 2kuhA-2dq7X:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esf CARBONIC ANHYDRASE 2

(Escherichia
coli) 		PF00484
(Pro_CA) 		4 LEU A 212
LEU A 134
GLU A 153
MET A 152
 None
 1.16A 2kuhA-2esfA:
undetectable		 2kuhA-2esfA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 LEU A 111
MET A  76
LEU A 118
MET A 108
 None
 1.28A 2kuhA-2f2aA:
undetectable		 2kuhA-2f2aA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 LEU A 240
LEU A 285
GLU A 278
MET A 273
 None
 1.23A 2kuhA-2hakA:
0.2		 2kuhA-2hakA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		4 LEU A 224
MET A 286
LEU A 288
GLU A 391
 None
 1.20A 2kuhA-2id0A:
undetectable		 2kuhA-2id0A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 337
LEU A 332
GLU A 349
MET A 354
 None
 1.30A 2kuhA-2nmpA:
0.0		 2kuhA-2nmpA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsg HYPOTHETICAL PROTEIN
CGL3021

(Corynebacterium
glutamicum) 		PF11716
(MDMPI_N) 		4 LEU A  63
LEU A 125
GLU A 136
MET A 140
 None
None
None
SO4  A 401 (-4.6A)
 1.08A 2kuhA-2nsgA:
undetectable		 2kuhA-2nsgA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A 446
MET A 408
LEU A 415
GLU A 441
 None
 1.30A 2kuhA-2nt2A:
undetectable		 2kuhA-2nt2A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A 205
LEU A 263
MET A 237
GLU A 236
 None
 1.24A 2kuhA-2plaA:
undetectable		 2kuhA-2plaA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 LEU A 184
LEU A 235
MET A 181
GLU A 180
 None
 1.24A 2kuhA-2q0oA:
undetectable		 2kuhA-2q0oA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Arabidopsis
thaliana) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A  72
MET A  57
LEU A  69
MET A  47
 None
 1.12A 2kuhA-2q49A:
undetectable		 2kuhA-2q49A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r50 NON-SYMBIOTIC
HEMOGLOBIN

(Zea mays) 		PF00042
(Globin) 		4 LEU A 133
MET A  28
MET A 137
MET A 142
 None
 1.29A 2kuhA-2r50A:
undetectable		 2kuhA-2r50A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE

(Streptomyces
avermitilis) 		PF05721
(PhyH) 		4 LEU A  56
LEU A  53
MET A  81
GLU A  78
 None
 1.19A 2kuhA-2rdsA:
undetectable		 2kuhA-2rdsA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 LEU A 143
MET A 284
GLU A 175
MET A 174
 None
None
MPD  A1299 (-3.4A)
None
 1.06A 2kuhA-2vy0A:
undetectable		 2kuhA-2vy0A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl8 PEROXISOMAL
BIOGENESIS FACTOR 19

(Homo sapiens) 		PF04614
(Pex19) 		4 LEU A 192
MET A 272
MET A 225
MET A 255
 None
 1.19A 2kuhA-2wl8A:
undetectable		 2kuhA-2wl8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 MET A 672
LEU A 654
MET A 501
GLU A 638
 None
 1.18A 2kuhA-2wtbA:
undetectable		 2kuhA-2wtbA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		4 MET A 409
LEU A 329
GLU A  25
MET A 261
 None
 0.98A 2kuhA-2x1mA:
undetectable		 2kuhA-2x1mA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 176
MET A 215
GLU A 360
MET A 328
 None
 1.12A 2kuhA-2yfkA:
undetectable		 2kuhA-2yfkA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 545
LEU A 543
MET A 396
GLU A 395
 None
 1.24A 2kuhA-3cr8A:
undetectable		 2kuhA-3cr8A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlj BETA-ALA-HIS
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 107
MET A  52
LEU A  48
GLU A 173
 None
None
None
UNX  A2004 ( 3.2A)
 1.23A 2kuhA-3dljA:
undetectable		 2kuhA-3dljA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8r PROBABLE SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
E

(Chromobacterium
violaceum) 		PF03102
(NeuB)
PF08666
(SAF) 		4 MET A  12
LEU A  45
MET A  87
GLU A  86
 None
 1.22A 2kuhA-3g8rA:
undetectable		 2kuhA-3g8rA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0o BETA-GLUCANASE

(Fibrobacter
succinogenes) 		PF00722
(Glyco_hydro_16) 		4 LEU A 103
MET A  39
LEU A 136
GLU A  24
 None
 1.18A 2kuhA-3h0oA:
undetectable		 2kuhA-3h0oA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 LEU T 236
MET T 253
LEU T 273
MET T 233
 None
 1.11A 2kuhA-3icqT:
undetectable		 2kuhA-3icqT:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ing HOMOSERINE
DEHYDROGENASE

(Thermoplasma
acidophilum) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 LEU A  77
MET A   9
LEU A  85
MET A  78
 None
 1.20A 2kuhA-3ingA:
undetectable		 2kuhA-3ingA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwo PUTATIVE
BACTERIOFERRITIN

(Campylobacter
jejuni) 		PF00210
(Ferritin) 		4 LEU A  50
LEU A  17
MET A  47
GLU A  46
 None
 1.26A 2kuhA-3kwoA:
undetectable		 2kuhA-3kwoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 LEU A 460
MET A 464
LEU A 515
GLU A 416
 None
 1.15A 2kuhA-3mi6A:
undetectable		 2kuhA-3mi6A:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A  20
LEU A  25
MET A   1
GLU A 100
 None
 1.22A 2kuhA-3nx4A:
undetectable		 2kuhA-3nx4A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Ralstonia
pickettii) 		PF13378
(MR_MLE_C) 		4 LEU A 447
LEU A 460
MET A 444
MET A  24
 None
 1.29A 2kuhA-3p0wA:
undetectable		 2kuhA-3p0wA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 4 LEU A 351
MET A 121
LEU A 318
GLU A 349
 None
 1.21A 2kuhA-3phfA:
undetectable		 2kuhA-3phfA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		4 LEU A 181
MET A 163
LEU A 171
GLU A 150
 None
 1.14A 2kuhA-3pnuA:
undetectable		 2kuhA-3pnuA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 LEU A 202
MET A 206
LEU A 216
MET A 189
 None
 1.20A 2kuhA-3q3cA:
undetectable		 2kuhA-3q3cA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 293
LEU A  43
MET A 295
GLU A 291
 None
 1.25A 2kuhA-3ut3A:
undetectable		 2kuhA-3ut3A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnp HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00132
(Hexapep) 		4 LEU A  95
LEU A 143
MET A 151
GLU A 150
 None
 1.08A 2kuhA-3vnpA:
undetectable		 2kuhA-3vnpA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		4 LEU A 105
MET A  84
LEU A 116
MET A 361
 None
None
None
EDO  A 403 (-4.7A)
 1.04A 2kuhA-3vzbA:
undetectable		 2kuhA-3vzbA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmj EIAV VACCINE GP45

(Equus caballus) 		no annotation 4 MET A 515
LEU A 512
MET B 575
GLU B 576
 None
 1.30A 2kuhA-3wmjA:
undetectable		 2kuhA-3wmjA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU C 115
LEU C 113
MET C 268
GLU C   9
 None
 1.18A 2kuhA-4b3iC:
undetectable		 2kuhA-4b3iC:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 LEU A 518
LEU A 596
MET A 512
MET A 846
 None
 1.29A 2kuhA-4czwA:
undetectable		 2kuhA-4czwA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfs GLYCOSIDE HYDROLASE,
FAMILY 16

(Thermotoga
petrophila) 		PF00722
(Glyco_hydro_16) 		4 LEU A 105
MET A 246
GLU A 137
MET A 136
 None
 1.18A 2kuhA-4dfsA:
undetectable		 2kuhA-4dfsA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dk0 PUTATIVE MACA

(Aggregatibacter
actinomycetemcomitans) 		PF16576
(HlyD_D23) 		4 LEU A 304
LEU A 216
MET A 219
GLU A  53
 None
 1.19A 2kuhA-4dk0A:
undetectable		 2kuhA-4dk0A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		4 LEU A  42
MET A 227
LEU A  44
MET A 203
 None
 1.24A 2kuhA-4ekdA:
undetectable		 2kuhA-4ekdA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 LEU A 428
LEU A 339
GLU A 332
MET A 310
 None
 1.09A 2kuhA-4f7zA:
1.4		 2kuhA-4f7zA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27

(Homo sapiens) 		no annotation 4 MET D 168
LEU D 197
MET D 179
GLU D 176
 None
 1.16A 2kuhA-4f9zD:
undetectable		 2kuhA-4f9zD:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 LEU A 339
LEU A 122
MET A 336
MET A  95
 None
 0.84A 2kuhA-4gqoA:
0.2		 2kuhA-4gqoA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpq UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF16011
(CBM9_2) 		4 LEU A 143
MET A 189
LEU A 187
GLU A 121
 None
None
None
CXS  A 301 ( 4.7A)
 1.13A 2kuhA-4jpqA:
undetectable		 2kuhA-4jpqA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpq UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF16011
(CBM9_2) 		4 LEU A 143
MET A 189
LEU A 187
GLU A 136
 None
None
None
CXS  A 301 ( 4.8A)
 1.13A 2kuhA-4jpqA:
undetectable		 2kuhA-4jpqA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4w ESPG3

(Mycolicibacterium
smegmatis) 		PF14011
(ESX-1_EspG) 		4 LEU A   8
LEU A 114
GLU A  51
MET A  55
 None
 1.21A 2kuhA-4l4wA:
undetectable		 2kuhA-4l4wA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 532
MET A 534
LEU A 558
MET A 523
 None
 0.97A 2kuhA-4mn8A:
undetectable		 2kuhA-4mn8A:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 558
MET A 534
LEU A 539
MET A 547
 None
 0.97A 2kuhA-4mn8A:
undetectable		 2kuhA-4mn8A:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 532
MET A 534
LEU A 558
MET A 523
 None
 0.92A 2kuhA-4mnaA:
undetectable		 2kuhA-4mnaA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 558
MET A 534
LEU A 539
MET A 547
 None
 0.91A 2kuhA-4mnaA:
undetectable		 2kuhA-4mnaA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR

(Escherichia
coli) 		PF00392
(GntR)
PF07729
(FCD) 		4 LEU A 151
MET A  95
LEU A  99
MET A 148
 None
 1.24A 2kuhA-4p9fA:
undetectable		 2kuhA-4p9fA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4reu FERRITIN

(Escherichia
coli) 		PF00210
(Ferritin) 		4 LEU A  23
MET A  27
LEU A  43
GLU A  94
 SO4  A 203 ( 4.9A)
None
None
FE  A 202 (-1.9A)
 1.25A 2kuhA-4reuA:
undetectable		 2kuhA-4reuA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rho UNCHARACTERIZED
PROTEIN

(Burkholderia
pseudomallei) 		PF15579
(Imm52) 		4 LEU A 120
LEU A 132
MET A   1
GLU A   2
 PGE  A 301 ( 4.8A)
PGE  A 301 ( 4.7A)
PGE  A 301 (-4.9A)
None
 1.26A 2kuhA-4rhoA:
undetectable		 2kuhA-4rhoA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 LEU A 267
MET A 226
LEU A 242
MET A 262
 None
 1.17A 2kuhA-4v1yA:
undetectable		 2kuhA-4v1yA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 MET A 362
LEU A 368
GLU A 373
MET A 386
 None
 1.11A 2kuhA-4wjlA:
undetectable		 2kuhA-4wjlA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0b ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  79
LEU H   4
MET H  34
GLU H  35
 None
 1.26A 2kuhA-4z0bH:
undetectable		 2kuhA-4z0bH:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a52 CALCIUM-DEPENDENT
LIPID-BINDING
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00168
(C2) 		4 LEU A 143
MET A 141
LEU A 124
GLU A  87
 None
 1.23A 2kuhA-5a52A:
undetectable		 2kuhA-5a52A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		4 LEU A 231
MET A 227
LEU A 348
GLU A 341
 None
 1.16A 2kuhA-5f2oA:
undetectable		 2kuhA-5f2oA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 582
MET A 230
LEU A 225
MET A 583
 None
 0.88A 2kuhA-5favA:
undetectable		 2kuhA-5favA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 LEU A1051
MET A1054
LEU A1058
GLU A1095
 None
 1.19A 2kuhA-5fqdA:
undetectable		 2kuhA-5fqdA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkk PUTATIVE HOMING
ENDONUCLEASE

(Thermotoga
neapolitana) 		PF00961
(LAGLIDADG_1) 		4 LEU A 139
LEU A 143
MET A 129
GLU A 130
 None
 1.30A 2kuhA-5gkkA:
undetectable		 2kuhA-5gkkA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwt 4-HYDROXYISOLECUINE
DEHYDROGENASE

(Bacillus
thuringiensis) 		no annotation 4 LEU A  81
MET A   8
LEU A  34
GLU A 118
 None
 1.29A 2kuhA-5gwtA:
undetectable		 2kuhA-5gwtA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hbt FAB35, HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU D  63
MET D  82
LEU D  80
MET D  48
 None
 1.25A 2kuhA-5hbtD:
undetectable		 2kuhA-5hbtD:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hbt FAB35, HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU D  80
MET D  48
LEU D  63
MET D  82
 None
 1.27A 2kuhA-5hbtD:
undetectable		 2kuhA-5hbtD:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixx ALR2278 PROTEIN

(Nostoc sp. PCC
7120) 		PF07700
(HNOB) 		4 LEU A 141
MET A 144
LEU A 148
MET A   1
 HEM  A 201 ( 4.7A)
6EX  A 202 ( 3.6A)
HEM  A 201 ( 3.4A)
6EX  A 202 (-4.2A)
 1.08A 2kuhA-5ixxA:
undetectable		 2kuhA-5ixxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 LEU A 517
MET A 509
LEU A 461
MET A 520
 LEU  A 517 ( 0.5A)
MET  A 509 ( 0.0A)
LEU  A 461 ( 0.6A)
MET  A 520 ( 0.0A)
 1.11A 2kuhA-5svdA:
undetectable		 2kuhA-5svdA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4t PUTATIVE GENTAMICIN
METHYLTRANSFERASE

(Micromonospora
echinospora) 		no annotation 4 LEU A  91
MET A  68
LEU A 163
MET A  25
 None
 1.09A 2kuhA-5u4tA:
undetectable		 2kuhA-5u4tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwz ALDEHYDE
DECARBONYLASE

(Gloeobacter
violaceus) 		no annotation 4 LEU A 211
LEU A 156
GLU A 168
MET A 224
 None
 0.97A 2kuhA-5uwzA:
undetectable		 2kuhA-5uwzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		4 LEU A 239
MET A 243
LEU A 463
GLU A 466
 None
 1.21A 2kuhA-5vj1A:
undetectable		 2kuhA-5vj1A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		4 LEU A 232
LEU A 253
MET A 233
GLU A 255
 None
 1.22A 2kuhA-5wayA:
2.4		 2kuhA-5wayA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 LEU A 770
MET A 671
LEU A 772
GLU A 748
 None
 0.82A 2kuhA-5xxoA:
undetectable		 2kuhA-5xxoA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 4 LEU A 110
LEU A 639
MET A  59
GLU A  56
 None
 1.27A 2kuhA-5ys9A:
undetectable		 2kuhA-5ys9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 4 LEU A 236
LEU A 449
GLU A 287
MET A 413
 None
 1.06A 2kuhA-5zb3A:
undetectable		 2kuhA-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax8 METHIONINE-TRNA
LIGASE

(Mycobacterium
tuberculosis) 		no annotation 4 MET A 407
LEU A 327
GLU A  24
MET A 259
 None
None
ME8  A 801 (-3.6A)
None
 1.02A 2kuhA-6ax8A:
undetectable		 2kuhA-6ax8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 113
MET A 121
LEU A 122
GLU A 209
 None
 1.28A 2kuhA-6b2qA:
0.4		 2kuhA-6b2qA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 4 LEU L 169
MET L 177
LEU L 179
GLU L 187
 None
 1.21A 2kuhA-6df3L:
undetectable		 2kuhA-6df3L:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 4 MET A 168
LEU A 202
MET A 237
GLU A 240
 None
 1.24A 2kuhA-6fuyA:
undetectable		 2kuhA-6fuyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 LEU A 576
LEU A 502
MET A 573
GLU A 572
 None
 1.09A 2kuhA-6gh2A:
undetectable		 2kuhA-6gh2A:
19.75