SIMILAR PATTERNS OF AMINO ACIDS FOR 2KUG_A_HLTA149

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 MET A 343
LEU A 346
MET A 296
LYS A 450
 None
 1.36A 2kugA-3ilvA:
1.4		 2kugA-3ilvA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kts GLYCEROL UPTAKE
OPERON
ANTITERMINATOR
REGULATORY PROTEIN

(Listeria
monocytogenes) 		PF04309
(G3P_antiterm) 		4 MET A  33
LEU A  57
MET A  20
LYS A  46
 None
 1.44A 2kugA-3ktsA:
undetectable		 2kugA-3ktsA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 MET A 482
LEU A 481
MET A 490
MET A 567
 None
 1.30A 2kugA-3vu2A:
0.0		 2kugA-3vu2A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx EXOU

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		4 MET B 123
LEU B 126
MET B 138
LYS B 280
 None
 1.40A 2kugA-4akxB:
undetectable		 2kugA-4akxB:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ug1 ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 4 MET A 471
LEU A 472
MET A 513
LYS A 505
 None
 1.35A 2kugA-5ug1A:
undetectable		 2kugA-5ug1A:
17.92