SIMILAR PATTERNS OF AMINO ACIDS FOR 2KQD_A_ADNA1002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kuo APRATAXIN AND
PNK-LIKE FACTOR

(Homo sapiens) 		PF10283
(zf-CCHH) 		4 TYR A 381
ASN A 384
CYH A 385
TYR A 386
 None
None
ZN  A 449 (-1.6A)
None
 0.91A 2kqdA-2kuoA:
0.0		 2kqdA-2kuoA:
91.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		4 TYR A 114
ASN A 113
CYH A 111
TYR A 115
 None
 1.29A 2kqdA-3e3pA:
0.0		 2kqdA-3e3pA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8u ORF1AB PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 TYR A 279
ASN A 114
CYH A 111
TYR A 112
 None
None
AYE  A 404 (-1.7A)
None
 1.41A 2kqdA-5w8uA:
0.0		 2kqdA-5w8uA:
16.06