SIMILAR PATTERNS OF AMINO ACIDS FOR 2KOT_B_ANWB99_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b88 T CELL RECEPTOR
V-ALPHA DOMAIN

(Mus musculus) 		PF07686
(V-set) 		4 ALA A  78
THR A  63
PHE A  62
ASP A  84
 None
 0.97A 2kotB-1b88A:
undetectable		 2kotB-1b88A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 VAL A 692
THR A 693
PHE A 694
THR A 695
 None
 1.20A 2kotB-1bf2A:
0.0		 2kotB-1bf2A:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 377
THR A 378
PHE A 379
ASP A 328
 None
 1.03A 2kotB-1bhyA:
undetectable		 2kotB-1bhyA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 ALA A 442
PHE A 406
THR A 407
LYS A 421
 None
 1.15A 2kotB-1d8cA:
0.0		 2kotB-1d8cA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f02 INTIMIN

(Escherichia
coli) 		PF02368
(Big_2)
PF02369
(Big_1)
PF07979
(Intimin_C) 		4 VAL I 696
THR I 697
PHE I 698
THR I 699
 None
 1.19A 2kotB-1f02I:
undetectable		 2kotB-1f02I:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 MET A 158
ALA A 157
THR A  39
THR A 308
 None
 0.98A 2kotB-1guqA:
undetectable		 2kotB-1guqA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H  68
PHE H  67
THR H  64
ASP H  86
 None
 1.27A 2kotB-1h3pH:
undetectable		 2kotB-1h3pH:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ALA A   2
VAL A 547
LYS A  10
ASP A  13
 None
 0.99A 2kotB-1hcyA:
undetectable		 2kotB-1hcyA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		4 VAL A 116
THR A 115
PHE A 114
THR A 113
 None
 0.94A 2kotB-1igoA:
undetectable		 2kotB-1igoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		4 ALA A 449
VAL A 428
PHE A 432
ASP A 447
 None
None
None
MG  A 593 (-4.2A)
 1.08A 2kotB-1ii0A:
0.0		 2kotB-1ii0A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 ALA A 738
THR A 750
THR A 748
ASP A 732
 None
 1.22A 2kotB-1kspA:
0.0		 2kotB-1kspA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 ALA A 139
VAL A  70
PHE A  74
THR A  75
 None
 0.99A 2kotB-1l8wA:
undetectable		 2kotB-1l8wA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ALA B  50
THR B 128
PHE B 130
THR B  58
 None
 1.06A 2kotB-1mu2B:
undetectable		 2kotB-1mu2B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE

(Escherichia
coli) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ALA A 159
VAL A 145
THR A 146
THR A 148
 None
 1.18A 2kotB-1nytA:
0.0		 2kotB-1nytA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5v F1 CAPSULE ANTIGEN

(Yersinia pestis) 		PF09255
(Antig_Caf1) 		4 ALA B 141
THR B 139
PHE B  74
THR B  75
 None
 1.12A 2kotB-1p5vB:
undetectable		 2kotB-1p5vB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 ALA A 447
VAL A 338
PHE A 348
THR A 347
 None
 1.16A 2kotB-1px8A:
0.0		 2kotB-1px8A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ALA A 176
VAL A 383
THR A 382
PHE A 377
 ALA  A 176 ( 0.0A)
VAL  A 383 ( 0.6A)
THR  A 382 ( 0.8A)
PHE  A 377 ( 1.3A)
 1.21A 2kotB-1tedA:
0.0		 2kotB-1tedA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3h T-CELL RECEPTOR
ALPHA-CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 ALA A  78
THR A  63
PHE A  62
ASP A  84
 None
 1.17A 2kotB-1u3hA:
undetectable		 2kotB-1u3hA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 MET A 370
ALA A 367
VAL A 531
THR A 526
 None
 1.18A 2kotB-1vbgA:
1.7		 2kotB-1vbgA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlm PROTEIN CGI-38

(Mus musculus) 		PF05517
(p25-alpha) 		4 VAL A 120
THR A 121
LYS A  47
ASP A  48
 None
 1.10A 2kotB-1wlmA:
4.3		 2kotB-1wlmA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 ALA A 673
VAL A 649
THR A 648
ASP A 587
 None
 1.05A 2kotB-1xdpA:
undetectable		 2kotB-1xdpA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1x LEISHMANIA MAJOR
HOMOLOG OF
PROGRAMMED CELL
DEATH 6 PROTEIN

(Leishmania
major) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 VAL A 176
THR A 177
PHE A 178
THR A 179
 None
 1.21A 2kotB-1y1xA:
5.1		 2kotB-1y1xA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 VAL A  20
THR A  21
PHE A  22
THR A  23
 None
 1.14A 2kotB-2dkdA:
undetectable		 2kotB-2dkdA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dm7 KIAA1556 PROTEIN

(Homo sapiens) 		PF07679
(I-set) 		4 ALA A  26
VAL A  92
THR A  91
THR A  89
 None
 1.26A 2kotB-2dm7A:
undetectable		 2kotB-2dm7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 ALA A 229
VAL A 246
PHE A 248
THR A 249
 None
 0.97A 2kotB-2f2aA:
undetectable		 2kotB-2f2aA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnw NON-SYMBIOTIC
HEMOGLOBIN 1

(Oryza sativa) 		PF00042
(Globin) 		4 ALA A  36
THR A 128
LYS A  29
ASP A  31
 None
 1.16A 2kotB-2gnwA:
undetectable		 2kotB-2gnwA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hd3 ETHANOLAMINE
UTILIZATION PROTEIN
EUTN

(Escherichia
coli) 		PF03319
(EutN_CcmL) 		4 VAL A   6
THR A  51
LYS A  23
ASP A  45
 None
 1.09A 2kotB-2hd3A:
undetectable		 2kotB-2hd3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxd DCTP DEAMINASE,
DUMP-FORMING

(Methanocaldococcus
jannaschii) 		PF00692
(dUTPase) 		4 ALA A 145
VAL A 191
THR A 143
THR A 100
 None
None
DUP  A 206 (-4.5A)
None
 1.18A 2kotB-2hxdA:
undetectable		 2kotB-2hxdA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l03 LY-6/NEUROTOXIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00087
(Toxin_TOLIP) 		4 ALA A  61
THR A  63
THR A  30
LYS A  40
 None
 1.27A 2kotB-2l03A:
undetectable		 2kotB-2l03A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltx E3 UBIQUITIN-PROTEIN
LIGASE SMURF1

(Homo sapiens) 		PF00397
(WW) 		4 VAL A 288
PHE A 298
THR A 306
ASP A 310
 None
 1.25A 2kotB-2ltxA:
undetectable		 2kotB-2ltxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obi PHOSPHOLIPID
HYDROPEROXIDE
GLUTATHIONE
PEROXIDASE (GPX4)

(Homo sapiens) 		PF00255
(GSHPx) 		4 VAL A  42
PHE A 138
THR A 139
LYS A  48
 None
 1.18A 2kotB-2obiA:
undetectable		 2kotB-2obiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1y BISPECIFIC
ALPHA/BETA TCR

(Mus musculus) 		PF07686
(V-set) 		4 ALA A 378
THR A 363
PHE A 362
ASP A 384
 None
 1.02A 2kotB-2p1yA:
undetectable		 2kotB-2p1yA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rn7 IS629 ORFA

(Shigella
flexneri) 		PF01527
(HTH_Tnp_1) 		4 MET A  18
ALA A  15
VAL A  51
THR A  46
 None
 1.14A 2kotB-2rn7A:
undetectable		 2kotB-2rn7A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmh FIBRONECTIN TYPE III
DOMAIN PROTEIN

(Clostridium
perfringens) 		PF08305
(NPCBM) 		4 ALA A1047
THR A 954
LYS A 927
ASP A 928
 None
 1.09A 2kotB-2vmhA:
undetectable		 2kotB-2vmhA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5p HAEMAGGLUTININ I

(Physarum
polycephalum) 		no annotation 4 ALA A  15
THR A  35
THR A  33
ASP A   9
 None
 1.04A 2kotB-3a5pA:
undetectable		 2kotB-3a5pA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmi PEROXIREDOXIN HYR1

(Saccharomyces
cerevisiae) 		PF00255
(GSHPx) 		4 MET A  93
VAL A  88
THR A  89
PHE A  90
 None
 1.15A 2kotB-3cmiA:
undetectable		 2kotB-3cmiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6a HYDROLASE, NUDIX
FAMILY

(Clostridium
perfringens) 		PF00293
(NUDIX) 		4 VAL A  12
THR A 104
THR A 106
ASP A  15
 None
 0.79A 2kotB-3f6aA:
undetectable		 2kotB-3f6aA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		4 ALA A 451
VAL A 545
THR A 481
ASP A 446
 None
 1.12A 2kotB-3fw6A:
undetectable		 2kotB-3fw6A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm4 CHEMOTAXIS PROTEIN
CHEX

(Desulfovibrio
alaskensis) 		PF13690
(CheX) 		4 VAL A  61
THR A  62
PHE A  63
THR A  64
 None
GOL  A 157 ( 4.4A)
None
None
 1.27A 2kotB-3hm4A:
undetectable		 2kotB-3hm4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4f 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Bacillus
thuringiensis) 		PF13561
(adh_short_C2) 		4 MET A 111
ALA A 110
VAL A  93
THR A  44
 None
 1.23A 2kotB-3i4fA:
undetectable		 2kotB-3i4fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9f POLIOVIRUS RECEPTOR

(Homo sapiens) 		PF08205
(C2-set_2) 		4 ALA 8 175
VAL 8 200
THR 8 201
THR 8 203
 None
 1.28A 2kotB-3j9f8:
undetectable		 2kotB-3j9f8:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzz TYPE IV PILIN
STRUCTURAL SUBUNIT

(Pseudomonas
aeruginosa) 		PF00114
(Pilin) 		4 THR A 155
PHE A 154
THR A 150
ASP A 138
 None
 1.02A 2kotB-3jzzA:
undetectable		 2kotB-3jzzA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		4 ALA A 153
VAL A 165
PHE A 161
THR A 160
 None
 1.10A 2kotB-3k6rA:
undetectable		 2kotB-3k6rA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ALA A 131
THR A 120
PHE A 123
THR A 122
 None
 0.77A 2kotB-3m07A:
undetectable		 2kotB-3m07A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		4 MET A 366
ALA A 365
VAL A  31
THR A  32
 None
None
None
FMT  A 387 ( 4.5A)
 1.27A 2kotB-3pmmA:
undetectable		 2kotB-3pmmA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		4 ALA A 156
THR A 151
THR A 149
LYS A 221
 None
 0.94A 2kotB-3pshA:
undetectable		 2kotB-3pshA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qoo UNCHARACTERIZED
PROTEIN

(Thermanaerovibrio
acidaminovorans) 		PF03061
(4HBT) 		4 VAL A  82
THR A  83
PHE A  84
THR A  85
 None
 1.07A 2kotB-3qooA:
undetectable		 2kotB-3qooA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		4 MET A 365
ALA A 364
VAL A  30
THR A  31
 None
 0.99A 2kotB-3qwtA:
undetectable		 2kotB-3qwtA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE

(Scaptodrosophila
lebanonensis) 		PF00106
(adh_short) 		4 VAL A  85
THR A  84
PHE A  79
LYS A  76
 None
 1.17A 2kotB-3rj9A:
undetectable		 2kotB-3rj9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN

(Candidatus
Pelagibacter
ubique) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ALA A  39
VAL A  26
THR A  27
PHE A  41
 None
 1.12A 2kotB-3tfjA:
undetectable		 2kotB-3tfjA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		4 ALA A  44
VAL A  23
THR A  24
ASP A  46
 None
 1.25A 2kotB-3uxyA:
undetectable		 2kotB-3uxyA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 VAL A  60
THR A 194
THR A 192
ASP A  66
 None
 1.26A 2kotB-3v8uA:
undetectable		 2kotB-3v8uA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2w CRISPR SYSTEM CMR
SUBUNIT CMR3

(Pyrococcus
furiosus) 		PF09700
(Cas_Cmr3) 		4 VAL B   4
THR B   5
PHE B   6
THR B   7
 None
 1.03A 2kotB-3w2wB:
undetectable		 2kotB-3w2wB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Coprinopsis
cinerea) 		no annotation 4 ALA A 125
PHE A 169
THR A 170
LYS A 119
 None
 1.10A 2kotB-3w9aA:
undetectable		 2kotB-3w9aA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP

(Bacillus
subtilis) 		PF00494
(SQS_PSY) 		4 ALA A 200
VAL A 197
THR A 196
PHE A 201
 None
 1.25A 2kotB-3we9A:
undetectable		 2kotB-3we9A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 ALA A 192
VAL A 163
THR A 164
THR A 166
 None
 1.08A 2kotB-3zk4A:
undetectable		 2kotB-3zk4A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		4 ALA A 251
VAL A 521
THR A 522
PHE A 248
 None
 1.15A 2kotB-4ainA:
undetectable		 2kotB-4ainA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c89 ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 ALA A  62
VAL A 119
THR A 118
ASP A 320
 None
 0.99A 2kotB-4c89A:
undetectable		 2kotB-4c89A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3r DUAL SPECIFICITY
PROTEIN PHOSPHATASE
19

(Homo sapiens) 		PF00782
(DSPc) 		4 VAL A  92
THR A  93
PHE A 110
THR A 111
 None
 1.12A 2kotB-4d3rA:
undetectable		 2kotB-4d3rA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		4 VAL A 116
PHE A 115
THR A 438
ASP A 393
 None
 1.04A 2kotB-4haqA:
undetectable		 2kotB-4haqA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN

(Bacteroides
ovatus) 		PF01833
(TIG) 		4 THR A 245
PHE A 250
THR A 251
ASP A 179
 None
 1.13A 2kotB-4hw6A:
undetectable		 2kotB-4hw6A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 VAL A  67
THR A  66
PHE A  92
THR A  64
 None
 1.24A 2kotB-4hwiA:
undetectable		 2kotB-4hwiA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 ALA A 455
VAL A 412
THR A 384
ASP A 440
 None
 1.00A 2kotB-4hwvA:
undetectable		 2kotB-4hwvA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 ACETALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 ALA B  75
THR B 282
THR B 286
ASP B  97
 None
 1.09A 2kotB-4jn6B:
undetectable		 2kotB-4jn6B:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnj STREPTAVIDIN/RHIZAVI
DIN HYBRID

(Streptomyces
avidinii) 		PF01382
(Avidin) 		4 VAL A  31
THR A  30
PHE A  29
THR A  28
 None
 1.24A 2kotB-4jnjA:
undetectable		 2kotB-4jnjA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3b OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Neisseria
gonorrhoeae) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 VAL A 335
THR A 334
PHE A 265
ASP A 236
 None
 1.25A 2kotB-4k3bA:
undetectable		 2kotB-4k3bA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		4 VAL A 409
THR A 410
PHE A 413
THR A 230
 None
 1.19A 2kotB-4mfiA:
undetectable		 2kotB-4mfiA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc8 RESTRICTION
ENDONUCLEASE ASPBHI

(Azoarcus sp.
BH72) 		PF04471
(Mrr_cat) 		4 ALA A 170
PHE A  80
THR A 173
ASP A  71
 None
 1.17A 2kotB-4oc8A:
undetectable		 2kotB-4oc8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		4 ALA B  84
THR B 131
THR B 133
LYS B  81
 None
 1.16A 2kotB-4pelB:
undetectable		 2kotB-4pelB:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 4 VAL H  91
THR H  92
PHE H  93
THR H  94
 None
 1.10A 2kotB-4qfkH:
undetectable		 2kotB-4qfkH:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01) 		PF07859
(Abhydrolase_3) 		4 ALA A 236
VAL A 166
THR A 189
ASP A 228
 None
 1.19A 2kotB-4v2iA:
undetectable		 2kotB-4v2iA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		4 ALA A 184
VAL A 173
PHE A 193
ASP A 234
 None
EDO  A 413 ( 3.9A)
EDO  A 413 ( 3.6A)
ACT  A 407 (-2.5A)
 1.24A 2kotB-4xdtA:
undetectable		 2kotB-4xdtA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG

(Haemophilus
influenzae) 		PF03595
(SLAC1) 		4 ALA A 206
VAL A 147
PHE A 151
THR A 152
 None
 0.69A 2kotB-4ycrA:
undetectable		 2kotB-4ycrA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 LIGHT CHAIN OF HJ16

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA L  73
THR L  79
PHE L  78
ASP L  37
 None
 1.15A 2kotB-4ye4L:
undetectable		 2kotB-4ye4L:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 VAL A 440
THR A 439
PHE A 317
ASP A 539
 None
GOL  A 703 (-4.5A)
None
None
 1.04A 2kotB-4ye5A:
undetectable		 2kotB-4ye5A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywn NADH-FMN
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF01613
(Flavin_Reduct) 		4 ALA A  39
VAL A  57
PHE A  55
THR A  42
 None
 0.88A 2kotB-4ywnA:
undetectable		 2kotB-4ywnA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Moraxella
catarrhalis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 THR A  60
THR A  38
LYS A  45
ASP A  44
 None
 1.20A 2kotB-4zqgA:
undetectable		 2kotB-4zqgA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi) 		PF03702
(AnmK) 		4 ALA A 191
VAL A 218
THR A 217
THR A 300
 None
 0.76A 2kotB-4zxzA:
undetectable		 2kotB-4zxzA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aho 5' EXONUCLEASE
APOLLO

(Homo sapiens) 		PF07522
(DRMBL) 		4 MET A 105
VAL A  92
PHE A 108
THR A 114
 None
 1.01A 2kotB-5ahoA:
undetectable		 2kotB-5ahoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 ALA A 486
PHE A 471
THR A 469
ASP A 488
 None
 1.27A 2kotB-5bymA:
undetectable		 2kotB-5bymA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5u PROLYL 4-HYDROXYLASE

(Paramecium
bursaria
Chlorella virus
1) 		PF13640
(2OG-FeII_Oxy_3) 		4 ALA A 222
PHE A 188
THR A 190
LYS A 194
 None
 0.82A 2kotB-5c5uA:
undetectable		 2kotB-5c5uA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		4 VAL A 195
THR A 196
THR A 386
LYS A 392
 None
GLC  A 501 ( 4.9A)
None
None
 1.10A 2kotB-5f7vA:
undetectable		 2kotB-5f7vA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghu PROBABLE FIMBRIAL
CHAPERONE YADV

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 ALA A  76
PHE A  53
THR A  54
LYS A  50
 None
 1.01A 2kotB-5ghuA:
undetectable		 2kotB-5ghuA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hi9 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2) 		4 MET A 255
VAL A 249
THR A 248
THR A 242
 None
 1.24A 2kotB-5hi9A:
undetectable		 2kotB-5hi9A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw1 T-CELL RECEPTOR
ALPHA CHAIN

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 ALA A  79
THR A  64
PHE A  63
ASP A  85
 None
 0.94A 2kotB-5iw1A:
undetectable		 2kotB-5iw1A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		4 ALA A 185
VAL A 157
THR A 158
LYS A 164
 PG4  A 523 ( 4.0A)
None
None
None
 1.20A 2kotB-5kc9A:
undetectable		 2kotB-5kc9A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 MET B 719
ALA B 690
PHE B 688
THR B 754
 None
 1.24A 2kotB-5kyuB:
undetectable		 2kotB-5kyuB:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 MET B 719
ALA B 690
THR B 753
PHE B 688
 None
 1.27A 2kotB-5kyuB:
undetectable		 2kotB-5kyuB:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0q MAB 8C7 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA C  58
VAL C  72
THR C  71
ASP C  55
 None
 1.06A 2kotB-5l0qC:
undetectable		 2kotB-5l0qC:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 ALA A  73
VAL A 234
THR A 235
PHE A 238
 None
 0.82A 2kotB-5l9wA:
undetectable		 2kotB-5l9wA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 VAL B 474
PHE B 463
THR B 452
LYS B 343
 None
 1.15A 2kotB-5m99B:
undetectable		 2kotB-5m99B:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6f COLD-SHOCK PROTEIN

(Corynebacterium
pseudotuberculosis) 		PF00313
(CSD) 		4 MET A   1
ALA A   2
VAL A  27
THR A   5
 None
 1.18A 2kotB-5o6fA:
undetectable		 2kotB-5o6fA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanothermobacter
marburgensis) 		no annotation 4 ALA A 329
PHE A 336
THR A 334
ASP A 321
 None
 1.27A 2kotB-5ok4A:
undetectable		 2kotB-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		4 ALA A 520
THR A 141
PHE A  87
THR A  84
 None
 1.23A 2kotB-5tj3A:
undetectable		 2kotB-5tj3A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 372
THR A 373
PHE A 374
ASP A 323
 None
 1.09A 2kotB-5u25A:
undetectable		 2kotB-5u25A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Burkholderia
multivorans) 		PF00155
(Aminotran_1_2) 		4 ALA A 210
VAL A 181
THR A 180
THR A 178
 9EV  A 242 ( 3.4A)
None
None
None
 1.17A 2kotB-5vnxA:
undetectable		 2kotB-5vnxA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		4 ALA A 524
PHE A 506
THR A 502
LYS A 507
 None
 1.05A 2kotB-5w1uA:
undetectable		 2kotB-5w1uA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 MET A 259
ALA A 258
VAL A 246
PHE A 226
 None
 1.15A 2kotB-6aphA:
undetectable		 2kotB-6aphA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3b UNCHARACTERIZED
PROTEIN

(Streptomyces
cattleya) 		no annotation 4 MET A 368
ALA A 323
VAL A 320
THR A 296
 None
 1.02A 2kotB-6c3bA:
undetectable		 2kotB-6c3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 4 MET A 233
ALA A 234
VAL A  60
THR A 264
 None
 0.76A 2kotB-6cblA:
undetectable		 2kotB-6cblA:
undetectable