SIMILAR PATTERNS OF AMINO ACIDS FOR 2KCE_A_D16A566_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bd8 P19INK4D CDK4/6
INHIBITOR

(Homo sapiens) 		PF12796
(Ank_2) 		3 HIS A 161
ILE A 111
LEU A 154
 None
 0.72A 2kceA-1bd8A:
undetectable		 2kceA-1bd8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		3 HIS A 191
ILE A 172
LEU A 177
 None
 0.72A 2kceA-1bg4A:
0.0		 2kceA-1bg4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1blx P19INK4D

(Mus musculus) 		PF13857
(Ank_5) 		3 HIS B 161
ILE B 111
LEU B 154
 None
 0.70A 2kceA-1blxB:
undetectable		 2kceA-1blxB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsz PROTEIN (PEPTIDE
DEFORMYLASE)

(Escherichia
coli) 		PF01327
(Pep_deformylase) 		3 HIS A 132
ILE A  60
LEU A 125
 FE  A2001 (-3.3A)
None
None
 0.77A 2kceA-1bszA:
0.0		 2kceA-1bszA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 HIS A  59
ILE A  49
LEU A 107
 SBT  A 353 ( 4.2A)
None
None
 0.77A 2kceA-1bxzA:
0.0		 2kceA-1bxzA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byr PROTEIN
(ENDONUCLEASE)

(Salmonella
enterica) 		PF13091
(PLDc_2) 		3 HIS A 140
ILE A  99
LEU A 133
 None
 0.53A 2kceA-1byrA:
0.0		 2kceA-1byrA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		3 HIS A 141
ILE A  22
LEU A  25
 None
ADN  A 375 ( 4.3A)
None
 0.74A 2kceA-1dgmA:
0.0		 2kceA-1dgmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 HIS A  89
ILE A 286
LEU A  96
 None
 0.61A 2kceA-1fc4A:
0.0		 2kceA-1fc4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 HIS A  69
ILE A  27
LEU A  19
 None
 0.73A 2kceA-1ff9A:
0.0		 2kceA-1ff9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		3 HIS A  41
ILE A  75
LEU A  22
 None
 0.63A 2kceA-1g7rA:
0.0		 2kceA-1g7rA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		3 HIS A 239
ILE A 221
LEU A 235
 ZN  A1452 ( 3.4A)
None
None
 0.69A 2kceA-1gkrA:
0.0		 2kceA-1gkrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 HIS A 226
ILE A 232
LEU A 103
 None
 0.75A 2kceA-1gwiA:
undetectable		 2kceA-1gwiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		3 HIS A 660
ILE A 640
LEU A 633
 None
 0.74A 2kceA-1j1wA:
undetectable		 2kceA-1j1wA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE

(Neurospora
crassa) 		PF10282
(Lactonase) 		3 HIS A   3
ILE A 336
LEU A  26
 BME  A 368 (-3.3A)
None
None
 0.71A 2kceA-1jofA:
undetectable		 2kceA-1jofA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		3 HIS A  71
ILE A  79
LEU A  64
 None
 0.73A 2kceA-1lc7A:
undetectable		 2kceA-1lc7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A  11
ILE A  74
LEU A 106
 None
 0.72A 2kceA-1llaA:
undetectable		 2kceA-1llaA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A  30
ILE A  76
LEU A  60
 None
 0.77A 2kceA-1llaA:
undetectable		 2kceA-1llaA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqw PEPTIDE DEFORMYLASE
PDF1

(Staphylococcus
aureus) 		PF01327
(Pep_deformylase) 		3 HIS A 154
ILE A  73
LEU A  41
 ZN  A 202 (-3.7A)
None
None
 0.70A 2kceA-1lqwA:
undetectable		 2kceA-1lqwA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9r AGROBACTERIUM
TUMEFACIENS DPS

(Agrobacterium
tumefaciens) 		PF00210
(Ferritin) 		3 HIS A  52
ILE A 103
LEU A 110
 None
 0.72A 2kceA-1o9rA:
undetectable		 2kceA-1o9rA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ode CHORISMATE MUTASE

(Thermus
thermophilus) 		PF07736
(CM_1) 		3 HIS A  20
ILE A  88
LEU A  27
 None
 0.66A 2kceA-1odeA:
undetectable		 2kceA-1odeA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 HIS A 302
ILE A 279
LEU A 328
 None
 0.70A 2kceA-1ozhA:
undetectable		 2kceA-1ozhA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 HIS A  24
ILE A 155
LEU A  17
 None
 0.74A 2kceA-1pgpA:
undetectable		 2kceA-1pgpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 HIS A 495
ILE A 454
LEU A 440
 None
 0.59A 2kceA-1pvdA:
undetectable		 2kceA-1pvdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 HIS A 292
ILE A 225
LEU A 206
 None
 0.71A 2kceA-1q8yA:
undetectable		 2kceA-1q8yA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 HIS A 138
ILE A 715
LEU A 691
 None
 0.73A 2kceA-1qb4A:
undetectable		 2kceA-1qb4A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		3 HIS A 449
ILE A 303
LEU A 240
 None
 0.54A 2kceA-1qguA:
undetectable		 2kceA-1qguA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3d CONSERVED
HYPOTHETICAL PROTEIN
VC1974

(Vibrio cholerae) 		PF12697
(Abhydrolase_6) 		3 HIS A  22
ILE A  71
LEU A  46
 None
 0.77A 2kceA-1r3dA:
undetectable		 2kceA-1r3dA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 HIS A1057
ILE A 995
LEU A1073
 None
 0.71A 2kceA-1rpmA:
undetectable		 2kceA-1rpmA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		3 HIS A 225
ILE A  78
LEU A 232
 None
 0.71A 2kceA-1s2nA:
undetectable		 2kceA-1s2nA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sw6 REGULATORY PROTEIN
SWI6

(Saccharomyces
cerevisiae) 		PF00023
(Ank)
PF13857
(Ank_5) 		3 HIS A 393
ILE A 391
LEU A 412
 None
 0.77A 2kceA-1sw6A:
undetectable		 2kceA-1sw6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uer SUPEROXIDE DISMUTASE

(Porphyromonas
gingivalis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 HIS A  74
ILE A   6
LEU A  53
 FE  A 192 (-3.3A)
None
None
 0.76A 2kceA-1uerA:
undetectable		 2kceA-1uerA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf1 KIAA1526 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		3 HIS A  83
ILE A  81
LEU A  90
 None
 0.76A 2kceA-1uf1A:
undetectable		 2kceA-1uf1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujj ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF00790
(VHS) 		3 HIS A  53
ILE A  14
LEU A  46
 None
 0.73A 2kceA-1ujjA:
undetectable		 2kceA-1ujjA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 HIS A 110
ILE A 276
LEU A 334
 None
 0.66A 2kceA-1um8A:
undetectable		 2kceA-1um8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		3 HIS A 315
ILE A 350
LEU A 319
 None
 0.71A 2kceA-1uzgA:
undetectable		 2kceA-1uzgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		3 HIS A  89
ILE A 103
LEU A 145
 GLC  A 900 (-4.0A)
None
None
 0.72A 2kceA-1venA:
undetectable		 2kceA-1venA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		3 HIS A 149
ILE A 178
LEU A  51
 None
 0.76A 2kceA-1vgpA:
undetectable		 2kceA-1vgpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		3 HIS A 150
ILE A 118
LEU A 109
 None
 0.66A 2kceA-1vi1A:
undetectable		 2kceA-1vi1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		3 HIS A 142
ILE A 358
LEU A 159
 None
 0.76A 2kceA-1vtkA:
undetectable		 2kceA-1vtkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		3 HIS C 255
ILE C 260
LEU C 246
 None
 0.74A 2kceA-1wa5C:
undetectable		 2kceA-1wa5C:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wly 2-HALOACRYLATE
REDUCTASE

(Burkholderia
sp. WS) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 HIS A 299
ILE A 161
LEU A 189
 HIS  A 299 ( 1.0A)
ILE  A 161 ( 0.6A)
LEU  A 189 ( 0.6A)
 0.66A 2kceA-1wlyA:
undetectable		 2kceA-1wlyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 HIS A 200
ILE A 107
LEU A 116
 None
 0.75A 2kceA-1womA:
undetectable		 2kceA-1womA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxq GTP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF08438
(MMR_HSR1_C) 		3 HIS A 107
ILE A 138
LEU A  96
 None
 0.72A 2kceA-1wxqA:
undetectable		 2kceA-1wxqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		3 HIS A  72
ILE A  74
LEU A  79
 None
 0.73A 2kceA-1x3wA:
undetectable		 2kceA-1x3wA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 HIS A 321
ILE A 336
LEU A 473
 None
 0.73A 2kceA-1xdpA:
undetectable		 2kceA-1xdpA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		3 HIS A 292
ILE A 126
LEU A 284
 None
 0.62A 2kceA-1xqwA:
undetectable		 2kceA-1xqwA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438

(Mycoplasma
genitalium) 		PF01420
(Methylase_S) 		3 HIS A 191
ILE A 340
LEU A 173
 None
 0.73A 2kceA-1ydxA:
undetectable		 2kceA-1ydxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		3 HIS A 185
ILE A 149
LEU A 178
 None
 0.77A 2kceA-1z6rA:
undetectable		 2kceA-1z6rA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		3 HIS A  71
ILE A  21
LEU A 120
 None
 0.59A 2kceA-1zl0A:
undetectable		 2kceA-1zl0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		3 HIS A   7
ILE A  81
LEU A 130
 None
 0.76A 2kceA-1zswA:
undetectable		 2kceA-1zswA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1x PHYTANOYL-COA
DIOXYGENASE

(Homo sapiens) 		PF05721
(PhyH) 		3 HIS A 264
ILE A 236
LEU A 217
 FE2  A 450 ( 3.4A)
None
None
 0.69A 2kceA-2a1xA:
undetectable		 2kceA-2a1xA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		3 HIS A 334
ILE A 339
LEU A 694
 None
 0.66A 2kceA-2a3lA:
undetectable		 2kceA-2a3lA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aie PEPTIDE DEFORMYLASE

(Streptococcus
pneumoniae) 		PF01327
(Pep_deformylase) 		3 HIS P 173
ILE P  84
LEU P  52
 NI  P 502 ( 3.4A)
None
None
 0.72A 2kceA-2aieP:
undetectable		 2kceA-2aieP:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		3 HIS A  54
ILE A 305
LEU A 315
 None
 0.75A 2kceA-2ay9A:
undetectable		 2kceA-2ay9A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b30 PVIVAX HYPOTHETICAL
PROTEIN

(Plasmodium
vivax) 		PF08282
(Hydrolase_3) 		3 HIS A 215
ILE A 195
LEU A 132
 None
 0.61A 2kceA-2b30A:
undetectable		 2kceA-2b30A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4a BH3024

(Bacillus
halodurans) 		PF00072
(Response_reg) 		3 HIS A  22
ILE A 113
LEU A 100
 None
 0.68A 2kceA-2b4aA:
undetectable		 2kceA-2b4aA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF10433
(MMS1_N) 		3 HIS A 536
ILE A 558
LEU A 576
 None
 0.71A 2kceA-2b5nA:
undetectable		 2kceA-2b5nA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		3 HIS A 182
ILE A 184
LEU A 122
 None
None
5ID  A1300 (-4.2A)
 0.55A 2kceA-2c47A:
undetectable		 2kceA-2c47A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew7 PEPTIDE DEFORMYLASE

(Helicobacter
pylori) 		PF01327
(Pep_deformylase) 		3 HIS A 138
ILE A  61
LEU A 131
 CO  A 300 (-3.3A)
None
None
 0.60A 2kceA-2ew7A:
undetectable		 2kceA-2ew7A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjc ANTIGEN TPF1

(Treponema
pallidum) 		PF00210
(Ferritin) 		3 HIS A  42
ILE A 156
LEU A  93
 None
 0.66A 2kceA-2fjcA:
undetectable		 2kceA-2fjcA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsr ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13302
(Acetyltransf_3) 		3 HIS A 101
ILE A  68
LEU A  96
 FMT  A 301 (-3.9A)
None
None
 0.71A 2kceA-2fsrA:
undetectable		 2kceA-2fsrA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Sulfurisphaera
tokodaii) 		PF04321
(RmlD_sub_bind) 		3 HIS A  90
ILE A  53
LEU A  41
 None
 0.70A 2kceA-2ggsA:
undetectable		 2kceA-2ggsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		3 HIS A  91
ILE A  54
LEU A  16
 None
 0.74A 2kceA-2gouA:
undetectable		 2kceA-2gouA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 HIS A  12
ILE A  41
LEU A  47
 None
 0.75A 2kceA-2hnhA:
undetectable		 2kceA-2hnhA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 HIS A 463
ILE A 421
LEU A 414
 None
 0.44A 2kceA-2i6tA:
undetectable		 2kceA-2i6tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF04494
(TFIID_NTD2) 		3 HIS A 276
ILE A 181
LEU A 268
 None
 0.69A 2kceA-2j49A:
undetectable		 2kceA-2j49A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		3 HIS A  93
ILE A  16
LEU A 156
 None
 0.67A 2kceA-2jk0A:
undetectable		 2kceA-2jk0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m85 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH

(Homo sapiens) 		PF00628
(PHD) 		3 HIS A 685
ILE A 662
LEU A 682
 ZN  A 801 (-3.1A)
None
ZN  A 802 ( 4.8A)
 0.76A 2kceA-2m85A:
undetectable		 2kceA-2m85A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8x LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa) 		PF04390
(LptE) 		3 HIS A  70
ILE A 104
LEU A  34
 None
 0.71A 2kceA-2n8xA:
undetectable		 2kceA-2n8xA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE

(Helicobacter
pylori) 		PF00852
(Glyco_transf_10) 		3 HIS A 298
ILE A 260
LEU A 305
 None
 0.68A 2kceA-2nzxA:
undetectable		 2kceA-2nzxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		3 HIS A 253
ILE A 351
LEU A 325
 None
 0.56A 2kceA-2o1oA:
undetectable		 2kceA-2o1oA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		3 HIS A  85
ILE A  87
LEU A 104
 None
 0.73A 2kceA-2o1sA:
undetectable		 2kceA-2o1sA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		3 HIS A 130
ILE A 132
LEU A 355
 None
 0.72A 2kceA-2o4jA:
undetectable		 2kceA-2o4jA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os1 PEPTIDE DEFORMYLASE

(Enterococcus
faecalis) 		PF01327
(Pep_deformylase) 		3 HIS A 157
ILE A  73
LEU A  41
 NI  A 300 ( 3.5A)
None
None
 0.75A 2kceA-2os1A:
undetectable		 2kceA-2os1A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oum 50S RIBOSOMAL
PROTEIN L1

(Thermus
thermophilus) 		PF00687
(Ribosomal_L1) 		3 HIS A 199
ILE A 171
LEU A 209
 None
 0.73A 2kceA-2oumA:
undetectable		 2kceA-2oumA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 HIS A 962
ILE A 885
LEU A 876
 MR9  A 301 (-4.5A)
MR9  A 301 ( 4.5A)
MR9  A 301 ( 4.5A)
 0.76A 2kceA-2p4iA:
undetectable		 2kceA-2p4iA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 HIS A  24
ILE A 155
LEU A  17
 None
 0.74A 2kceA-2p4qA:
undetectable		 2kceA-2p4qA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF02542
(YgbB) 		3 HIS A  45
ILE A  80
LEU A  52
 ZN  A 500 (-3.1A)
None
None
 0.74A 2kceA-2pmpA:
undetectable		 2kceA-2pmpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0z PROTEIN PRO2281

(Homo sapiens) 		PF02889
(Sec63) 		3 HIS X  81
ILE X 108
LEU X 115
 None
 0.74A 2kceA-2q0zX:
undetectable		 2kceA-2q0zX:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3f RAS-RELATED
GTP-BINDING PROTEIN
D

(Homo sapiens) 		PF04670
(Gtr1_RagA) 		3 HIS A 178
ILE A 159
LEU A 139
 None
 0.72A 2kceA-2q3fA:
undetectable		 2kceA-2q3fA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		3 HIS A 144
ILE A  52
LEU A  67
 None
 0.55A 2kceA-2rkbA:
undetectable		 2kceA-2rkbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 HIS A 495
ILE A 454
LEU A 440
 None
 0.54A 2kceA-2vk4A:
undetectable		 2kceA-2vk4A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vli ANTIBIOTIC
RESISTANCE PROTEIN

(Deinococcus
radiodurans) 		no annotation 3 HIS A 107
ILE A 165
LEU A  29
 None
 0.50A 2kceA-2vliA:
undetectable		 2kceA-2vliA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 HIS A 333
ILE A 391
LEU A 426
 None
 0.66A 2kceA-2vpqA:
undetectable		 2kceA-2vpqA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsk HEMAGGLUTININ-NEURAM
INIDASE

(Hendra
henipavirus) 		PF00423
(HN) 		3 HIS A 281
ILE A 279
LEU A 234
 None
 0.76A 2kceA-2vskA:
undetectable		 2kceA-2vskA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT

(Homo sapiens) 		PF11566
(PI31_Prot_N) 		3 HIS A  33
ILE A 142
LEU A  78
 None
 0.72A 2kceA-2vt8A:
undetectable		 2kceA-2vt8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wja PUTATIVE ACID
PHOSPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		3 HIS A  67
ILE A  54
LEU A  62
 None
 0.50A 2kceA-2wjaA:
undetectable		 2kceA-2wjaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdd TOXN

(Pectobacterium
atrosepticum) 		PF13958
(ToxN_toxin) 		3 HIS A  45
ILE A  92
LEU A  14
 None
 0.66A 2kceA-2xddA:
undetectable		 2kceA-2xddA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xq1 PEROXISOMAL CATALASE

(Ogataea angusta) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 HIS A 302
ILE A 271
LEU A  90
 None
 0.70A 2kceA-2xq1A:
undetectable		 2kceA-2xq1A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhm NUCLEOPROTEIN

(Human
orthopneumovirus) 		PF03246
(Pneumo_ncap) 		3 HIS A 216
ILE A  33
LEU A  68
 None
 0.72A 2kceA-2yhmA:
undetectable		 2kceA-2yhmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymb MIT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF16565
(MIT_C) 		3 HIS A 152
ILE A 120
LEU A 141
 None
 0.69A 2kceA-2ymbA:
undetectable		 2kceA-2ymbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		3 HIS A 329
ILE A 161
LEU A 336
 None
 0.77A 2kceA-2z2zA:
undetectable		 2kceA-2z2zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 HIS A 151
ILE A  81
LEU A  70
 None
 0.70A 2kceA-2ztgA:
undetectable		 2kceA-2ztgA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 HIS A 296
ILE A 298
LEU A 316
 None
 0.77A 2kceA-3aflA:
undetectable		 2kceA-3aflA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		3 HIS A 388
ILE A  71
LEU A  74
 None
 0.70A 2kceA-3aqiA:
undetectable		 2kceA-3aqiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 HIS A 125
ILE A 182
LEU B  43
 None
 0.70A 2kceA-3ayxA:
undetectable		 2kceA-3ayxA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b54 NUCLEOSIDE
DIPHOSPHATE KINASE

(Saccharomyces
cerevisiae) 		PF00334
(NDK) 		3 HIS A 119
ILE A  74
LEU A  48
 PO4  A 154 (-3.6A)
None
None
 0.68A 2kceA-3b54A:
undetectable		 2kceA-3b54A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8i PA4872 OXALOACETATE
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF13714
(PEP_mutase) 		3 HIS A 202
ILE A 199
LEU A 226
 None
 0.74A 2kceA-3b8iA:
undetectable		 2kceA-3b8iA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		3 HIS A 137
ILE A  76
LEU A  68
 None
 0.74A 2kceA-3bqrA:
undetectable		 2kceA-3bqrA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 3 HIS A 317
ILE A 426
LEU A 280
 EDO  A 490 (-4.1A)
None
None
 0.71A 2kceA-3c8vA:
undetectable		 2kceA-3c8vA:
20.00