SIMILAR PATTERNS OF AMINO ACIDS FOR 2KAW_A_SUZA91

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f15 COAT PROTEIN

(Cucumber mosaic
virus) 		PF00760
(Cucumo_coat) 		5 LEU A 107
ILE A 205
SER A  72
ILE A  73
VAL A 125
 None
 0.96A 2kawA-1f15A:
undetectable		 2kawA-1f15A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkm PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis) 		PF00381
(PTS-HPr) 		5 LEU H  53
GLY H  54
ILE H  55
VAL H  23
VAL H  42
 None
 0.95A 2kawA-1kkmH:
undetectable		 2kawA-1kkmH:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		5 ILE A 168
SER A 169
VAL A 185
LEU A 184
VAL A 259
 None
 1.02A 2kawA-1l5xA:
undetectable		 2kawA-1l5xA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 ILE A 195
SER A 196
ILE A 197
MET A 146
VAL A 218
 None
 0.91A 2kawA-1mqqA:
undetectable		 2kawA-1mqqA:
11.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU A 682
GLY A 683
ILE A 684
ILE A 686
LEU A 739
 None
 0.98A 2kawA-1n7fA:
12.5		 2kawA-1n7fA:
31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		5 LEU A  80
GLY A  78
ILE A  77
SER A  74
ILE A  73
 None
 0.83A 2kawA-1o9iA:
undetectable		 2kawA-1o9iA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		5 LEU A 340
GLY A 425
ILE A 424
ILE A 421
MET A 433
 None
GDP  A1603 (-3.2A)
None
None
None
 1.03A 2kawA-1p9bA:
undetectable		 2kawA-1p9bA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmy PROTEASE

(Foot-and-mouth
disease virus) 		PF05408
(Peptidase_C28) 		5 GLY A 114
ILE A 115
ILE A 104
LEU A  59
VAL A  63
 None
 1.02A 2kawA-1qmyA:
undetectable		 2kawA-1qmyA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 LEU A 216
SER A 132
ILE A 131
VAL A 196
LEU A 207
 None
 1.00A 2kawA-1t1uA:
undetectable		 2kawA-1t1uA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		5 GLY A 154
SER A 173
ILE A 174
LEU A 198
VAL A 200
 None
EDO  A1296 (-2.7A)
None
None
None
 0.93A 2kawA-1uv4A:
undetectable		 2kawA-1uv4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve0 HYPOTHETICAL PROTEIN
(ST2072)

(Sulfurisphaera
tokodaii) 		PF01894
(UPF0047) 		5 GLY A  94
ILE A  93
SER A  90
ILE A  89
VAL A  69
 None
 1.02A 2kawA-1ve0A:
undetectable		 2kawA-1ve0A:
27.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wf8 NEURABIN-I

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A  22
GLY A  23
ILE A  24
SER A  25
ILE A  26
 None
 0.63A 2kawA-1wf8A:
10.7		 2kawA-1wf8A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x5q LAP4 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A  28
GLY A  29
ILE A  30
SER A  31
ILE A  32
 None
 0.72A 2kawA-1x5qA:
9.6		 2kawA-1x5qA:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2byg CHANNEL ASSOCIATED
PROTEIN OF
SYNAPSE-110

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 203
GLY A 204
SER A 206
ILE A 207
VAL A 262
 None
 0.86A 2kawA-2bygA:
12.3		 2kawA-2bygA:
30.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 LEU A  36
ILE A   4
SER A   5
ARG A  28
VAL A  32
 None
 0.94A 2kawA-2cevA:
undetectable		 2kawA-2cevA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 431
SER A 240
VAL A 447
ARG A 451
VAL A 454
 None
 0.90A 2kawA-2cgjA:
undetectable		 2kawA-2cgjA:
12.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dc2 GOLGI ASSOCIATED PDZ
AND COILED-COIL
MOTIF CONTAINING
ISOFORM B

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A  24
ILE A  25
SER A  26
VAL A  77
LEU A  80
 None
 0.90A 2kawA-2dc2A:
12.2		 2kawA-2dc2A:
31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		5 LEU A  14
GLY A  21
ILE A  39
ILE A 101
VAL A 121
 None
 0.99A 2kawA-2e47A:
undetectable		 2kawA-2e47A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcf MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A1163
ILE A1164
SER A1165
VAL A1225
ARG A1229
 None
 0.73A 2kawA-2fcfA:
11.8		 2kawA-2fcfA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcf MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		6 LEU A1162
GLY A1163
ILE A1164
SER A1165
ILE A1166
VAL A1225
 None
 0.94A 2kawA-2fcfA:
11.8		 2kawA-2fcfA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		5 LEU A  92
GLY A  93
ILE A 108
ILE A 149
VAL A 122
 None
 1.03A 2kawA-2i9eA:
undetectable		 2kawA-2i9eA:
17.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iwn MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 387
GLY A 388
ILE A 389
ILE A 391
VAL A 445
 None
 0.56A 2kawA-2iwnA:
13.4		 2kawA-2iwnA:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iwn MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 387
GLY A 388
ILE A 391
VAL A 445
LEU A 448
 None
 0.77A 2kawA-2iwnA:
13.4		 2kawA-2iwnA:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwo MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A1845
GLY A1846
ILE A1847
SER A1848
ILE A1849
 None
 0.60A 2kawA-2iwoA:
11.6		 2kawA-2iwoA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwq MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A1163
ILE A1164
SER A1165
VAL A1225
ARG A1229
 None
 0.80A 2kawA-2iwqA:
11.9		 2kawA-2iwqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwq MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		6 LEU A1162
GLY A1163
ILE A1164
SER A1165
ILE A1166
VAL A1225
 None
 0.93A 2kawA-2iwqA:
11.9		 2kawA-2iwqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		5 ILE A 180
VAL A 127
LEU A 130
ARG A 131
VAL A 135
 None
 0.97A 2kawA-2j0wA:
undetectable		 2kawA-2j0wA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbg NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3) 		5 PHE A  18
GLY A  10
SER A  21
ILE A  22
VAL A  73
 None
 1.00A 2kawA-2kbgA:
undetectable		 2kawA-2kbgA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1

(Mus musculus) 		PF00595
(PDZ) 		9 PHE A 261
LEU A 262
GLY A 263
ILE A 264
ILE A 266
MET A 284
VAL A 318
LEU A 321
VAL A 325
 None
 0.65A 2kawA-2mx6A:
19.6		 2kawA-2mx6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1

(Mus musculus) 		PF00595
(PDZ) 		8 PHE A 261
LEU A 262
GLY A 263
ILE A 264
SER A 265
ILE A 266
LEU A 321
VAL A 325
 None
 0.69A 2kawA-2mx6A:
19.6		 2kawA-2mx6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzc GLUTAREDOXIN

(Brucella
melitensis) 		PF00462
(Glutaredoxin) 		5 LEU A  73
GLY A  69
ILE A  60
ILE A  62
LEU A  85
 None
 0.96A 2kawA-2mzcA:
undetectable		 2kawA-2mzcA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbx HEMAGGLUTININ/PROTEA
SE REGULATORY
PROTEIN

(Vibrio cholerae) 		PF00440
(TetR_N) 		5 GLY A 169
ILE A 170
SER A 173
ILE A 174
VAL A 102
 None
 1.00A 2kawA-2pbxA:
undetectable		 2kawA-2pbxA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q66 POLY(A) POLYMERASE

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		5 GLY A 150
ILE A 151
SER A 152
ILE A 153
LEU A  55
 None
 0.93A 2kawA-2q66A:
undetectable		 2kawA-2q66A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 LEU A  18
GLY A 264
ILE A 265
ILE A 294
LEU A 250
 None
 0.96A 2kawA-2qfqA:
undetectable		 2kawA-2qfqA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		5 LEU A 262
ILE A 261
ILE A  91
LEU A 206
VAL A 202
 None
 1.02A 2kawA-2uutA:
undetectable		 2kawA-2uutA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrf BETA-2-SYNTROPHIN

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 126
GLY A 127
ILE A 128
SER A 129
ILE A 130
 None
 0.64A 2kawA-2vrfA:
11.8		 2kawA-2vrfA:
27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w4f PROTEIN LAP4

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 738
GLY A 739
ILE A 740
SER A 741
ILE A 742
 None
 0.80A 2kawA-2w4fA:
10.8		 2kawA-2w4fA:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		5 ILE A 280
SER A 279
ILE A 278
LEU A 133
VAL A 144
 None
 0.84A 2kawA-2xfbA:
undetectable		 2kawA-2xfbA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 241
VAL A 270
LEU A 273
ARG A 274
VAL A 278
 None
 1.01A 2kawA-2yv2A:
undetectable		 2kawA-2yv2A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		5 ILE A 746
ILE A 661
VAL A 626
LEU A 627
VAL A 631
 None
 0.90A 2kawA-2zzgA:
undetectable		 2kawA-2zzgA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE
SLIDING CLAMP

(Pyrococcus
furiosus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU B 141
ILE B 155
VAL B 201
LEU B 204
VAL B 208
 None
 0.92A 2kawA-3a2fB:
undetectable		 2kawA-3a2fB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		5 GLY A 198
ILE A 201
SER A 200
VAL A 262
VAL A 168
 SO4  A 269 ( 4.6A)
None
None
None
None
 1.03A 2kawA-3b8bA:
undetectable		 2kawA-3b8bA:
14.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cbx DISHEVELLED-2

(Homo sapiens) 		PF00595
(PDZ) 		8 PHE A 277
LEU A 278
GLY A 279
ILE A 280
SER A 281
ILE A 282
VAL A 334
LEU A 337
 None
 0.59A 2kawA-3cbxA:
16.8		 2kawA-3cbxA:
88.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cbx DISHEVELLED-2

(Homo sapiens) 		PF00595
(PDZ) 		9 PHE A 277
LEU A 278
GLY A 279
ILE A 280
SER A 281
VAL A 334
LEU A 337
ARG A 338
VAL A 341
 None
 0.68A 2kawA-3cbxA:
16.8		 2kawA-3cbxA:
88.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		5 LEU A  90
GLY A  89
ILE A  87
ILE A  32
LEU A  30
 None
 0.65A 2kawA-3cerA:
undetectable		 2kawA-3cerA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		5 GLY A 340
SER A 362
ILE A 361
LEU A 292
VAL A 290
 None
 0.96A 2kawA-3e38A:
undetectable		 2kawA-3e38A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG

(Sulfolobus
solfataricus) 		PF01890
(CbiG_C)
PF11760
(CbiG_N) 		5 GLY A 219
ILE A 218
SER A 217
ILE A 216
LEU A 242
 None
 0.95A 2kawA-3eeqA:
undetectable		 2kawA-3eeqA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egh SPINOPHILIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU C 506
GLY C 507
ILE C 508
SER C 509
ILE C 510
 None
 0.58A 2kawA-3eghC:
12.7		 2kawA-3eghC:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6g ALPHA-ISOPROPYLMALAT
E SYNTHASE

(Leptospira
interrogans) 		no annotation 5 GLY B 445
ILE B 446
SER B 447
ILE B 448
LEU B 437
 None
 0.76A 2kawA-3f6gB:
undetectable		 2kawA-3f6gB:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fy5 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2

(Xenopus laevis) 		PF00595
(PDZ) 		6 PHE A 264
LEU A 265
GLY A 266
ILE A 267
SER A 268
ILE A 269
 None
 0.66A 2kawA-3fy5A:
15.3		 2kawA-3fy5A:
85.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fy5 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2

(Xenopus laevis) 		PF00595
(PDZ) 		6 PHE A 264
LEU A 265
GLY A 266
ILE A 267
SER A 268
VAL A 328
 None
 0.67A 2kawA-3fy5A:
15.3		 2kawA-3fy5A:
85.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvq NEURABIN-1

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU C 515
GLY C 516
ILE C 517
SER C 518
ILE C 519
 None
 0.51A 2kawA-3hvqC:
12.9		 2kawA-3hvqC:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 LEU A  90
GLY A  91
ILE A  74
VAL A  33
LEU A  37
 None
None
None
PO4  A 800 (-3.9A)
None
 0.93A 2kawA-3i6bA:
undetectable		 2kawA-3i6bA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 PHE A  59
GLY A 224
ILE A 225
ILE A 215
LEU A 163
 None
 0.98A 2kawA-3ll3A:
undetectable		 2kawA-3ll3A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 LEU A 380
GLY A 320
ILE A 389
VAL A 293
VAL A 311
 None
 0.98A 2kawA-3lpsA:
undetectable		 2kawA-3lpsA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mao METHIONINE-R-SULFOXI
DE REDUCTASE B1

(Homo sapiens) 		PF01641
(SelR) 		5 LEU A  78
GLY A  79
ILE A  96
SER A  95
VAL A  55
 None
None
None
MLI  A   4 (-2.5A)
None
 1.03A 2kawA-3maoA:
undetectable		 2kawA-3maoA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 357
GLY A 358
ILE A 359
SER A 360
ILE A 361
 None
 0.52A 2kawA-3my9A:
undetectable		 2kawA-3my9A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1u HYDROLASE, HAD
SUPERFAMILY,
SUBFAMILY III A

(Legionella
pneumophila) 		PF08282
(Hydrolase_3) 		5 LEU A  83
GLY A  84
ILE A  67
VAL A  26
LEU A  30
 None
 0.80A 2kawA-3n1uA:
undetectable		 2kawA-3n1uA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1u HYDROLASE, HAD
SUPERFAMILY,
SUBFAMILY III A

(Legionella
pneumophila) 		PF08282
(Hydrolase_3) 		5 LEU A  83
GLY A  84
ILE A  85
ILE A  67
LEU A  30
 None
 0.97A 2kawA-3n1uA:
undetectable		 2kawA-3n1uA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2

(Homo sapiens) 		PF04495
(GRASP55_65) 		5 LEU A  96
GLY A  97
SER A  99
ILE A 100
LEU A  55
 None
 0.75A 2kawA-3rleA:
3.9		 2kawA-3rleA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tq7 MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF03271
(EB1) 		5 LEU B 255
GLY B 253
ILE B 252
SER B 249
ILE B 248
 None
 0.90A 2kawA-3tq7B:
undetectable		 2kawA-3tq7B:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A  47
GLY A  48
SER A  50
VAL A   8
LEU A  84
 None
 0.89A 2kawA-3u92A:
undetectable		 2kawA-3u92A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubh NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		5 GLY A 704
SER A 672
ILE A 671
LEU A 742
VAL A 727
 None
 0.94A 2kawA-3ubhA:
undetectable		 2kawA-3ubhA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 LEU A 302
GLY A 303
ILE A 304
SER A 305
VAL A 257
 HEC  A 424 ( 4.3A)
None
HEC  A 424 ( 4.2A)
None
None
 0.76A 2kawA-4aalA:
undetectable		 2kawA-4aalA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 LEU A 145
GLY A 143
ILE A 142
SER A 139
VAL A  43
 None
 0.99A 2kawA-4bjuA:
undetectable		 2kawA-4bjuA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Yersinia pestis) 		PF00005
(ABC_tran) 		5 LEU C  53
ILE C  42
VAL C 227
LEU C 226
VAL C  30
 None
 0.94A 2kawA-4g1uC:
undetectable		 2kawA-4g1uC:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heh APPA PROTEIN

(Rhodobacter
sphaeroides) 		no annotation 5 GLY A 358
SER A 360
ILE A 361
VAL A 347
LEU A 350
 None
 1.03A 2kawA-4hehA:
undetectable		 2kawA-4hehA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itq PUTATIVE
UNCHARACTERIZED
PROTEIN SCO1480

(Streptomyces
coelicolor) 		no annotation 5 LEU A  79
GLY A  80
ILE A  81
SER A  82
LEU A  61
 None
 0.99A 2kawA-4itqA:
undetectable		 2kawA-4itqA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jof GOLGI-ASSOCIATED PDZ
AND COILED-COIL
MOTIF-CONTAINING
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 299
GLY A 300
ILE A 301
SER A 302
ILE A 303
 None
 0.64A 2kawA-4jofA:
12.5		 2kawA-4jofA:
34.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 GLY A 385
ILE A 388
VAL A 394
LEU A  82
VAL A  71
 None
 0.94A 2kawA-4ny4A:
undetectable		 2kawA-4ny4A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 LEU A 429
ILE A 280
ILE A 302
LEU A 401
VAL A 408
 None
 1.04A 2kawA-4pfyA:
undetectable		 2kawA-4pfyA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 GLY A 174
SER A 170
ILE A 169
VAL A 195
LEU A 196
 None
 1.00A 2kawA-4px1A:
undetectable		 2kawA-4px1A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 GLY A 132
ILE A 131
SER A 130
ILE A 128
VAL A 228
 None
None
None
PO4  A 301 (-4.1A)
None
 0.91A 2kawA-4rncA:
undetectable		 2kawA-4rncA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4thi PROTEIN (THIAMINASE
I)

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		5 LEU A 155
GLY A 154
ILE A 139
ILE A 126
LEU A 117
 None
 0.65A 2kawA-4thiA:
undetectable		 2kawA-4thiA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500

(Pyrococcus
horikoshii) 		PF02933
(CDC48_2) 		5 GLY A  43
ILE A  44
SER A  45
ILE A  46
LEU A  19
 None
 0.86A 2kawA-4uzrA:
undetectable		 2kawA-4uzrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyu PROTEIN SCRIBBLE
HOMOLOG

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 121
GLY A 122
ILE A 123
SER A 124
ILE A 125
 None
IOD  A 301 (-4.2A)
None
None
None
 0.72A 2kawA-4wyuA:
10.9		 2kawA-4wyuA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		5 LEU A 192
GLY A 191
SER A 187
VAL A 319
VAL A 149
 None
None
SO4  A 501 ( 4.6A)
None
None
 0.87A 2kawA-4xguA:
undetectable		 2kawA-4xguA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 LEU A 253
GLY A 250
ILE A 249
ILE A 236
LEU A 232
 None
 1.01A 2kawA-4xh9A:
undetectable		 2kawA-4xh9A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLY A 171
SER A 166
ILE A 165
LEU A 129
VAL A 125
 None
 0.98A 2kawA-4ye5A:
undetectable		 2kawA-4ye5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		5 LEU A  90
GLY A  89
ILE A  88
SER A 155
LEU A  50
 None
 0.95A 2kawA-4yshA:
undetectable		 2kawA-4yshA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5any E1

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		5 ILE A 280
SER A 279
ILE A 278
LEU A 133
VAL A 144
 None
 0.82A 2kawA-5anyA:
undetectable		 2kawA-5anyA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 5 ILE A 143
SER A 144
ILE A 145
LEU A 164
VAL A 169
 None
 0.76A 2kawA-5bw4A:
undetectable		 2kawA-5bw4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 LEU A 379
ILE A 386
VAL A 229
LEU A 232
VAL A 236
 None
 0.97A 2kawA-5e4rA:
undetectable		 2kawA-5e4rA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		5 GLY A 276
SER A 230
ILE A 229
LEU A 288
VAL A 307
 FMT  A 603 ( 3.8A)
None
None
None
None
 0.82A 2kawA-5esoA:
undetectable		 2kawA-5esoA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2

(Mus musculus) 		PF04495
(GRASP55_65) 		5 LEU A  96
GLY A  97
SER A  99
ILE A 100
LEU A  55
 None
 0.82A 2kawA-5gmlA:
3.5		 2kawA-5gmlA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 5 SER A 283
ILE A 282
VAL A 244
LEU A 247
VAL A 251
 None
 0.72A 2kawA-5o5cA:
undetectable		 2kawA-5o5cA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 GLY A  60
ILE A  61
SER A  64
VAL A 101
LEU A  48
 None
 0.98A 2kawA-5tulA:
undetectable		 2kawA-5tulA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv2 ELONGATION FACTOR G

(Vibrio
vulnificus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 GLY A  14
ILE A  15
ILE A  30
LEU A 279
VAL A 282
 None
 1.03A 2kawA-5tv2A:
undetectable		 2kawA-5tv2A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzn KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY B MEMBER
1B ALLELE B

(Mus musculus) 		PF00059
(Lectin_C) 		5 LEU A 156
GLY A 155
ILE A 154
ILE A 132
LEU A 178
 None
None
None
None
NAG  A 302 (-4.7A)
 0.94A 2kawA-5tznA:
undetectable		 2kawA-5tznA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uk3 UNCHARACTERIZED
PROTEIN

(Tetranychus
urticae) 		PF02560
(Cyanate_lyase) 		5 LEU A  71
GLY A  72
ILE A  73
SER A  74
LEU A  81
 None
 0.94A 2kawA-5uk3A:
undetectable		 2kawA-5uk3A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6b PDZ
DOMAIN-CONTAINING
PROTEIN GIPC1

(Mus musculus) 		PF00595
(PDZ) 		5 ILE A 157
SER A 173
ILE A 172
VAL A 134
LEU A 209
 None
 1.02A 2kawA-5v6bA:
11.2		 2kawA-5v6bA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
ambifaria) 		PF13561
(adh_short_C2) 		5 GLY A  22
ILE A  51
VAL A  59
LEU A  34
VAL A  12
 None
 0.97A 2kawA-5vpsA:
undetectable		 2kawA-5vpsA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vwk PROTEIN SCRIBBLE
HOMOLOG

(Homo sapiens) 		no annotation 5 GLY A 739
ILE A 740
SER A 741
ILE A 742
VAL A 797
 None
 0.97A 2kawA-5vwkA:
10.7		 2kawA-5vwkA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vwk PROTEIN SCRIBBLE
HOMOLOG

(Homo sapiens) 		no annotation 5 GLY A 739
SER A 741
ILE A 742
VAL A 797
ARG A 801
 None
 1.03A 2kawA-5vwkA:
10.7		 2kawA-5vwkA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vwk PROTEIN SCRIBBLE
HOMOLOG

(Homo sapiens) 		no annotation 5 LEU A 738
GLY A 739
ILE A 740
SER A 741
ILE A 742
 None
 0.75A 2kawA-5vwkA:
10.7		 2kawA-5vwkA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r PROTEIN CS22

(Spinacia
oleracea) 		no annotation 5 GLY v 166
ILE v 126
ILE v 193
LEU v 188
VAL v 133
 None
 1.00A 2kawA-5x8rv:
undetectable		 2kawA-5x8rv:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdy HEAT SHOCK PROTEIN
HTRA

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 442
GLY A 443
ILE A 444
SER A 445
VAL A 497
 None
 0.44A 2kawA-5xdyA:
7.1		 2kawA-5xdyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 LEU C  68
GLY C 135
ILE C 134
ILE C  77
VAL C 152
 None
 0.96A 2kawA-5y6qC:
undetectable		 2kawA-5y6qC:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 5 GLY A 151
SER A 170
ILE A 171
LEU A 195
VAL A 197
 None
 0.93A 2kawA-6b7kA:
undetectable		 2kawA-6b7kA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 5 LEU A 539
ILE A 536
ILE A 532
VAL A 452
VAL A 517
 None
 0.95A 2kawA-6cthA:
undetectable		 2kawA-6cthA:
22.35