SIMILAR PATTERNS OF AMINO ACIDS FOR 2JN3_A_JN3A131_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au1 INTERFERON-BETA

(Homo sapiens) 		PF00143
(Interferon) 		4 LEU A  87
ASN A 158
ILE A  66
PHE A  70
 None
 1.16A 2jn3A-1au1A:
0.0		 2jn3A-1au1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgf STAT-4

(Mus musculus) 		PF02865
(STAT_int) 		4 LEU A  60
ASN A 107
GLN A   3
ILE A  38
 None
 1.18A 2jn3A-1bgfA:
0.0		 2jn3A-1bgfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb1 CALBINDIN D9K

(Sus scrofa) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		4 LEU A  49
LYS A  29
GLN A   0
ILE A  73
 None
 1.08A 2jn3A-1cb1A:
undetectable		 2jn3A-1cb1A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER

(Thermochromatium
tepidum) 		PF00124
(Photo_RC) 		4 LEU L 139
ASN L 178
GLN L 171
PHE L 154
 BCL  L 602 (-4.4A)
None
None
BCL  L 604 (-3.5A)
 1.21A 2jn3A-1eysL:
0.0		 2jn3A-1eysL:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipk BETA-CONGLYCININ,
BETA CHAIN

(Glycine max) 		PF00190
(Cupin_1)
PF07883
(Cupin_2) 		4 LEU A 125
ASN A  37
ILE A 340
PHE A 338
 None
 0.99A 2jn3A-1ipkA:
0.3		 2jn3A-1ipkA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1

(Neisseria
gonorrhoeae) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 LEU A 216
GLN A 171
ILE A 169
PHE A 167
 None
 1.13A 2jn3A-1kbvA:
0.0		 2jn3A-1kbvA:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		4 LEU A  93
LYS A   1
ILE A  42
PHE A   4
 None
 1.24A 2jn3A-1kqxA:
18.3		 2jn3A-1kqxA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7p PHOSPHOSERINE
PHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF12710
(HAD) 		4 LEU A 203
LYS A 200
ILE A 182
PHE A 184
 None
 1.24A 2jn3A-1l7pA:
0.0		 2jn3A-1l7pA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 LEU A 151
ASN B 266
GLN B 194
ILE B 191
 None
 1.23A 2jn3A-1m1jA:
undetectable		 2jn3A-1m1jA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmf IGG2A-KAPPA R6.5 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  86
LYS H  67
GLN H   6
ILE H  20
 None
 1.18A 2jn3A-1rmfH:
undetectable		 2jn3A-1rmfH:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg3 ALLANTOICASE

(Saccharomyces
cerevisiae) 		PF03561
(Allantoicase) 		4 LEU A  48
ASN A 108
GLN A 147
ILE A 100
 None
 1.19A 2jn3A-1sg3A:
undetectable		 2jn3A-1sg3A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		4 LEU A 208
GLN A 168
ILE A 173
PHE A 242
 None
 0.83A 2jn3A-1t5eA:
undetectable		 2jn3A-1t5eA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		4 LEU A1679
GLN A1739
ILE A1672
PHE A1675
 None
 0.87A 2jn3A-1u4qA:
undetectable		 2jn3A-1u4qA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		4 LEU B 410
ASN A 151
ILE B 390
PHE B 397
 None
 1.24A 2jn3A-1w2wB:
undetectable		 2jn3A-1w2wB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		4 LEU A 228
ASN A 310
GLN A 303
ILE A 322
 None
 1.09A 2jn3A-1x9yA:
undetectable		 2jn3A-1x9yA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		4 LEU A 124
LYS A 108
GLN A 138
ILE A 115
 None
 1.18A 2jn3A-1xr4A:
undetectable		 2jn3A-1xr4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		4 LEU A 151
ASN A 203
LYS A 127
ILE A  27
 None
 1.22A 2jn3A-1xzzA:
undetectable		 2jn3A-1xzzA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 LEU A 102
ASN A 163
LYS A 329
PHE A 333
 None
 0.99A 2jn3A-1zl6A:
undetectable		 2jn3A-1zl6A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvy IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		4 LEU A 109
LYS A  65
GLN A  72
ILE A  70
 None
 1.15A 2jn3A-1zvyA:
undetectable		 2jn3A-1zvyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c27 MYCOTHIOL SYNTHASE

(Mycobacterium
tuberculosis) 		PF00583
(Acetyltransf_1) 		4 LEU A 204
ASN A 171
GLN A 245
PHE A 206
 None
None
COA  A1314 (-3.5A)
None
 1.17A 2jn3A-2c27A:
undetectable		 2jn3A-2c27A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crf RAN BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		4 LEU A  36
ASN A  57
ILE A 103
PHE A 116
 None
 1.21A 2jn3A-2crfA:
undetectable		 2jn3A-2crfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1m ACRIFLAVINE
RESISTANCE PROTEIN A

(Escherichia
coli) 		PF16576
(HlyD_D23) 		4 LEU A 246
GLN A 207
ILE A 212
PHE A 280
 None
 0.78A 2jn3A-2f1mA:
undetectable		 2jn3A-2f1mA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 437
ASN A 161
GLN A 453
ILE A 471
 None
 1.17A 2jn3A-2isaA:
1.0		 2jn3A-2isaA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgn ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00271
(Helicase_C) 		4 LEU A 456
ASN A 435
ILE A 513
PHE A 515
 None
 0.89A 2jn3A-2jgnA:
undetectable		 2jn3A-2jgnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli) 		PF00781
(DAGK_cat) 		4 LEU A 223
ASN A 137
ILE A 280
PHE A 256
 None
 1.20A 2jn3A-2jgrA:
undetectable		 2jn3A-2jgrA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llf VILLIN-1

(Gallus gallus) 		PF00626
(Gelsolin) 		4 LEU A  33
ASN A   8
ILE A  44
PHE A  42
 None
 1.23A 2jn3A-2llfA:
undetectable		 2jn3A-2llfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		4 LEU A 585
ASN A 574
GLN A 534
ILE A 561
 None
 0.95A 2jn3A-2v5iA:
3.4		 2jn3A-2v5iA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfo GLYCOPROTEIN 1

(Machupo
mammarenavirus) 		PF00798
(Arena_glycoprot) 		4 LEU A 152
ASN A  96
ILE A 179
PHE A 177
 None
 1.21A 2jn3A-2wfoA:
undetectable		 2jn3A-2wfoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 LEU A 305
GLN A 338
ILE A 298
PHE A 301
 None
 1.07A 2jn3A-2xijA:
undetectable		 2jn3A-2xijA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8f RAN-BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		4 LEU A 340
ASN A 361
ILE A 407
PHE A 420
 None
 1.08A 2jn3A-2y8fA:
1.4		 2jn3A-2y8fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 584
ASN A 565
GLN A 524
PHE A 608
 None
 1.21A 2jn3A-3dduA:
undetectable		 2jn3A-3dduA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 LEU B  98
ASN B 371
GLN B  43
PHE B  99
 None
 1.24A 2jn3A-3draB:
undetectable		 2jn3A-3draB:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 182
ASN A 224
ILE A 241
PHE A 215
 None
 1.06A 2jn3A-3ekgA:
0.2		 2jn3A-3ekgA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 521
ASN A 689
LYS A 535
PHE A 532
 None
 1.23A 2jn3A-3fn9A:
undetectable		 2jn3A-3fn9A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 LEU A 313
ASN A 319
GLN A 270
PHE A 281
 LEU  A 313 ( 0.5A)
ASN  A 319 ( 0.6A)
GLN  A 270 ( 0.6A)
PHE  A 281 ( 1.3A)
 1.21A 2jn3A-3gnrA:
undetectable		 2jn3A-3gnrA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 LEU A 207
LYS A 236
GLN A 225
ILE A 229
 None
 1.07A 2jn3A-3hlmA:
undetectable		 2jn3A-3hlmA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ica PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Porphyromonas
gingivalis) 		no annotation 4 LEU A  63
ASN A  73
GLN A 197
PHE A 201
 None
GOL  A 214 ( 4.8A)
None
None
 1.23A 2jn3A-3icaA:
undetectable		 2jn3A-3icaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igq GLR4197 PROTEIN

(Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		4 LEU A  24
GLN A 193
ILE A 162
PHE A 165
 HG  A 700 ( 3.9A)
None
None
None
 0.97A 2jn3A-3igqA:
undetectable		 2jn3A-3igqA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		4 LEU D 393
ASN D   9
GLN D 498
ILE D 502
 None
 0.91A 2jn3A-3j9eD:
1.9		 2jn3A-3j9eD:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		4 LEU A 523
ASN A 514
LYS A 576
PHE A 580
 None
 1.15A 2jn3A-3javA:
undetectable		 2jn3A-3javA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kip 3-DEHYDROQUINASE,
TYPE II

(Candida
albicans) 		PF01220
(DHquinase_II) 		4 LEU A  92
GLN A  52
ILE A   7
PHE A  99
 None
 1.15A 2jn3A-3kipA:
undetectable		 2jn3A-3kipA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		4 LEU A 324
GLN A 271
ILE A 251
PHE A 252
 None
 0.96A 2jn3A-3ktcA:
undetectable		 2jn3A-3ktcA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes) 		PF01244
(Peptidase_M19) 		4 LEU A 272
ASN A  32
ILE A 265
PHE A 224
 None
 1.14A 2jn3A-3lu2A:
undetectable		 2jn3A-3lu2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2p UDP-N-ACETYLGLUCOSAM
INE 4-EPIMERASE

(Bacillus cereus) 		PF01370
(Epimerase) 		4 LEU A 272
LYS A 154
ILE A 222
PHE A 220
 None
 1.14A 2jn3A-3m2pA:
undetectable		 2jn3A-3m2pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0z ADENYLATE CYCLASE 2

(Yersinia pestis) 		PF01928
(CYTH) 		4 ASN A 159
LYS A 120
GLN A  26
ILE A 123
 None
 1.07A 2jn3A-3n0zA:
2.3		 2jn3A-3n0zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4c DE NOVO DESIGNED
BETA-TREFOIL
ARCHITECTURE WITH
SYMMETRIC PRIMARY
STRUCTURE

(synthetic
construct) 		PF00167
(FGF) 		4 LEU A  23
ASN A  68
GLN A  84
PHE A 132
 None
 1.14A 2jn3A-3o4cA:
undetectable		 2jn3A-3o4cA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6c PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		PF03740
(PdxJ) 		4 LEU A  71
ASN A  66
GLN A 144
ILE A 114
 None
 1.24A 2jn3A-3o6cA:
undetectable		 2jn3A-3o6cA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7t CYCLOPHILIN A

(Moniliophthora
perniciosa) 		PF00160
(Pro_isomerase) 		4 LEU A 134
ASN A   3
LYS A  92
ILE A 112
 None
 1.23A 2jn3A-3o7tA:
undetectable		 2jn3A-3o7tA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ory FLAP ENDONUCLEASE 1

(Desulfurococcus
amylolyticus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 LEU A 272
ASN A 229
ILE A 249
PHE A 246
 None
 1.20A 2jn3A-3oryA:
undetectable		 2jn3A-3oryA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 ASN A 404
GLN A 467
ILE A 356
PHE A 354
 EDO  A 477 ( 4.7A)
None
None
None
 1.10A 2jn3A-3rc0A:
undetectable		 2jn3A-3rc0A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  31
GLN A 164
ILE A  88
PHE A  91
 None
 1.17A 2jn3A-3rg2A:
undetectable		 2jn3A-3rg2A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svi TYPE III EFFECTOR
HOPAB2

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 LEU A 208
ASN A 184
ILE A 163
PHE A 167
 None
CL  A   3 (-3.5A)
None
None
 1.24A 2jn3A-3sviA:
undetectable		 2jn3A-3sviA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		4 ASN A 172
GLN A 124
ILE A 135
PHE A 134
 None
 1.16A 2jn3A-3td9A:
undetectable		 2jn3A-3td9A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tni CYCLIN-T1

(Homo sapiens) 		PF00134
(Cyclin_N) 		4 LEU B 241
ASN B  43
GLN B  56
PHE B 187
 None
 1.24A 2jn3A-3tniB:
undetectable		 2jn3A-3tniB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 LYS A1174
GLN A1119
ILE A1229
PHE A1223
 None
 0.93A 2jn3A-3u44A:
undetectable		 2jn3A-3u44A:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 113
ASN A 211
GLN A 218
PHE A 172
 None
 1.24A 2jn3A-3vi3A:
undetectable		 2jn3A-3vi3A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh9 DELTA

(Bacillus
subtilis) 		PF06144
(DNA_pol3_delta) 		4 LEU B 333
GLN B 217
ILE B 237
PHE B 238
 None
 1.21A 2jn3A-3zh9B:
undetectable		 2jn3A-3zh9B:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 157
ASN A 218
ILE A 237
PHE A 230
 None
FM6  A 501 (-3.4A)
None
None
 1.16A 2jn3A-3zhyA:
undetectable		 2jn3A-3zhyA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		4 LEU A 134
ASN A 209
GLN A  87
ILE A  68
 None
None
AZM  A 302 (-4.4A)
None
 1.22A 2jn3A-4g7aA:
1.2		 2jn3A-4g7aA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 207
ASN A 148
ILE A 216
PHE A 219
 None
 1.21A 2jn3A-4hpnA:
undetectable		 2jn3A-4hpnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		4 LEU A 376
GLN A 621
ILE A 406
PHE A 404
 None
 1.03A 2jn3A-4hsuA:
undetectable		 2jn3A-4hsuA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l95 GAMMA-GLUTAMYL
HYDROLASE

(Danio rerio) 		no annotation 4 LEU E  93
ASN E 181
ILE E 212
PHE E 210
 None
 1.19A 2jn3A-4l95E:
undetectable		 2jn3A-4l95E:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mli FIBRONECTIN BINDING
PROTEIN

(Streptococcus
pyogenes) 		PF02986
(Fn_bind) 		4 LEU A  46
ASN A 103
ILE A  27
PHE A  66
 None
 1.17A 2jn3A-4mliA:
undetectable		 2jn3A-4mliA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ole NEXT TO BRCA1 GENE 1
PROTEIN

(Homo sapiens) 		PF16158
(N_BRCA1_IG) 		4 LEU A 419
LYS A 394
GLN A 387
PHE A 446
 None
 1.04A 2jn3A-4oleA:
undetectable		 2jn3A-4oleA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Bacillus
subtilis) 		no annotation 4 LEU A  49
ASN A  16
GLN A   7
ILE A   2
 None
 1.02A 2jn3A-4p8iA:
undetectable		 2jn3A-4p8iA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 LEU A 136
ASN A 189
GLN A 171
ILE A 150
 None
 1.11A 2jn3A-4p8sA:
undetectable		 2jn3A-4p8sA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdy PARATHION HYDROLASE

(Vulcanisaeta
moutnovskia) 		PF02126
(PTE) 		4 ASN A 176
GLN A 212
ILE A 183
PHE A 186
 None
None
GOL  A 407 ( 4.2A)
None
 1.22A 2jn3A-4rdyA:
undetectable		 2jn3A-4rdyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Gloeobacter
violaceus;
Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 LEU A  24
GLN A 219
ILE A 162
PHE A 165
 None
 1.06A 2jn3A-4x5tA:
undetectable		 2jn3A-4x5tA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycs UNCHARACTERIZED
PROTEIN

(Clostridioides
difficile) 		PF02608
(Bmp) 		4 ASN A  85
GLN A 131
ILE A  99
PHE A  95
 None
 1.07A 2jn3A-4ycsA:
undetectable		 2jn3A-4ycsA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjg ALPHA-2-MACROGLOBULI
N

(Escherichia
coli) 		PF11974
(MG1) 		4 LEU A  83
LYS A 157
GLN A  95
ILE A 101
 None
PG4  A 401 (-2.8A)
None
None
 1.13A 2jn3A-4zjgA:
undetectable		 2jn3A-4zjgA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 142
ASN A 104
ILE A  82
PHE A  80
 None
SO4  A 806 (-3.1A)
None
None
 0.95A 2jn3A-4zlgA:
0.8		 2jn3A-4zlgA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		4 ASN A 264
GLN A 154
ILE A 184
PHE A 176
 None
 1.12A 2jn3A-5a08A:
undetectable		 2jn3A-5a08A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 LEU A 281
ASN A 249
ILE A 207
PHE A 183
 None
 1.20A 2jn3A-5dl7A:
1.8		 2jn3A-5dl7A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 LEU B 452
ASN B  21
ILE B 369
PHE B 459
 None
 0.75A 2jn3A-5do8B:
undetectable		 2jn3A-5do8B:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1

(Fervidobacterium
islandicum) 		PF02074
(Peptidase_M32) 		4 LEU A 204
ASN A 327
ILE A 244
PHE A 200
 None
 1.16A 2jn3A-5e3xA:
undetectable		 2jn3A-5e3xA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 457
ASN A 436
ILE A 514
PHE A 516
 None
 0.89A 2jn3A-5e7jA:
undetectable		 2jn3A-5e7jA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 LEU A2258
ASN A2204
GLN A2213
ILE A2215
 None
 1.22A 2jn3A-5fu7A:
undetectable		 2jn3A-5fu7A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 4 LEU I  60
ASN I  66
GLN I  31
ILE I  53
 None
 1.16A 2jn3A-5furI:
undetectable		 2jn3A-5furI:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU B 470
ASN B 522
ILE B 485
PHE B 461
 None
 0.94A 2jn3A-5gqrB:
undetectable		 2jn3A-5gqrB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		4 ASN A 324
GLN A  56
ILE A  63
PHE A  96
 None
 1.03A 2jn3A-5gvvA:
undetectable		 2jn3A-5gvvA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl3 LMO2470 PROTEIN

(Listeria
monocytogenes) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 LEU A 266
ASN A 233
GLN A 292
ILE A 287
 None
 1.24A 2jn3A-5hl3A:
undetectable		 2jn3A-5hl3A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		4 LEU A 171
ASN A  90
LYS A 158
ILE A 184
 None
 1.15A 2jn3A-5izdA:
undetectable		 2jn3A-5izdA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 4 ASN A  18
GLN A 123
ILE A 192
PHE A 191
 None
None
None
AKG  A 301 (-4.1A)
 1.17A 2jn3A-5j4rA:
undetectable		 2jn3A-5j4rA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 LEU A 256
ASN A 313
GLN A  42
ILE A 267
 None
 1.22A 2jn3A-5kucA:
undetectable		 2jn3A-5kucA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU B 261
GLN B  53
ILE A  54
PHE A  50
 None
 1.17A 2jn3A-5mkkB:
undetectable		 2jn3A-5mkkB:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 4 LEU A  44
ASN A 143
ILE A  22
PHE A  31
 None
 1.24A 2jn3A-5n7qA:
undetectable		 2jn3A-5n7qA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 LEU A 363
ASN A  57
GLN A 347
ILE A 350
 None
NAG  A1101 (-1.8A)
None
None
 1.19A 2jn3A-5nbsA:
undetectable		 2jn3A-5nbsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA

(Escherichia
coli) 		no annotation 4 LEU E 246
GLN E 207
ILE E 212
PHE E 280
 None
 0.93A 2jn3A-5ng5E:
undetectable		 2jn3A-5ng5E:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 4 LEU A  61
ASN A 355
ILE A 374
PHE A 378
 None
 1.13A 2jn3A-5o82A:
0.8		 2jn3A-5o82A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Gloeobacter
violaceus;
Mus musculus) 		no annotation 4 LEU A  23
GLN A 192
ILE A 161
PHE A 164
 None
 1.11A 2jn3A-5osbA:
undetectable		 2jn3A-5osbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tta PUTATIVE EXPORTED
PROTEIN

(Clostridioides
difficile) 		no annotation 4 LEU A  67
LYS A 162
GLN A  75
ILE A  88
 None
 1.16A 2jn3A-5ttaA:
undetectable		 2jn3A-5ttaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2u HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		PF02861
(Clp_N) 		4 LEU A 117
ASN A  70
ILE A 126
PHE A 121
 None
 1.01A 2jn3A-5u2uA:
undetectable		 2jn3A-5u2uA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 4 LEU C  24
GLN C 193
ILE C 162
PHE C 165
 None
 1.07A 2jn3A-5v6nC:
undetectable		 2jn3A-5v6nC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wan PYRIMIDINE
MONOOXYGENASE RUTA

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		4 LEU A 329
ASN A  65
GLN A 122
PHE A 206
 None
None
None
FMN  A 409 ( 4.5A)
 1.16A 2jn3A-5wanA:
undetectable		 2jn3A-5wanA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 LEU A 996
ASN A1014
GLN A1021
ILE A1062
 None
 0.90A 2jn3A-5wlhA:
undetectable		 2jn3A-5wlhA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x47 3-DEHYDROQUINATE
DEHYDRATASE

(Acinetobacter
baumannii) 		PF01220
(DHquinase_II) 		4 LEU A  91
GLN A  51
ILE A   8
PHE A  98
 None
 1.13A 2jn3A-5x47A:
undetectable		 2jn3A-5x47A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 LEU A 529
ASN A 419
GLN A 504
ILE A 539
 None
 1.23A 2jn3A-5x7hA:
undetectable		 2jn3A-5x7hA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 4 LYS A 209
GLN A 124
ILE A 180
PHE A 205
 None
None
MTA  A 401 (-3.6A)
None
 1.17A 2jn3A-5xncA:
undetectable		 2jn3A-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A  33
GLN A  23
ILE A  21
PHE A  19
 None
 1.12A 2jn3A-6c6lA:
undetectable		 2jn3A-6c6lA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 LEU D 666
LYS D  52
GLN D 302
PHE D  53
 None
None
EDO  D 705 (-3.6A)
None
 1.12A 2jn3A-6eq8D:
undetectable		 2jn3A-6eq8D:
22.05