SIMILAR PATTERNS OF AMINO ACIDS FOR 2JN3_A_JN3A131

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0u HISTIDINE PERMEASE

(Salmonella
enterica) 		PF00005
(ABC_tran) 		5 VAL A 114
THR A  96
LEU A 175
VAL A 140
PHE A 177
 None
 1.28A 2jn3A-1b0uA:
undetectable		 2jn3A-1b0uA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjx PROTEIN DISULFIDE
ISOMERASE

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		5 PHE A 144
ILE A 169
THR A 121
LEU A 123
VAL A 186
 None
 1.25A 2jn3A-1bjxA:
undetectable		 2jn3A-1bjxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1p TYROSINE PHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01451
(LMWPc) 		5 ILE A  12
THR A  48
LEU A 101
PHE A  84
HIS A  83
 None
 1.18A 2jn3A-1d1pA:
undetectable		 2jn3A-1d1pA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dby CHLOROPLAST
THIOREDOXIN M CH2

(Chlamydomonas
reinhardtii) 		PF00085
(Thioredoxin) 		5 VAL A  41
ILE A  89
THR A  76
VAL A 102
LEU A  52
 None
 1.05A 2jn3A-1dbyA:
0.0		 2jn3A-1dbyA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		5 PHE A 180
ILE A 263
THR A 271
LEU A 265
LEU A 151
 None
 1.21A 2jn3A-1ezrA:
undetectable		 2jn3A-1ezrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mus musculus) 		PF00268
(Ribonuc_red_sm) 		5 VAL A 131
PHE A 127
THR A 257
VAL A 311
LEU A 305
 None
 1.20A 2jn3A-1h0nA:
undetectable		 2jn3A-1h0nA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2h HYPOTHETICAL PROTEIN
TM1643

(Thermotoga
maritima) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		5 VAL A 180
ILE A 169
THR A 168
LEU A 113
HIS A 193
 None
 1.12A 2jn3A-1h2hA:
undetectable		 2jn3A-1h2hA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 VAL S 387
PHE S 398
ILE S 393
VAL S 609
LEU S 430
 None
 1.11A 2jn3A-1i84S:
0.3		 2jn3A-1i84S:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 PHE A 327
ILE A 381
LEU A 411
CYH A 385
LEU A 261
 None
 1.26A 2jn3A-1iidA:
0.0		 2jn3A-1iidA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhe LEXA REPRESSOR

(Escherichia
coli) 		PF00717
(Peptidase_S24) 		5 VAL A 133
THR A 154
LEU A 167
VAL A 139
PHE A 186
 None
 0.89A 2jn3A-1jheA:
undetectable		 2jn3A-1jheA:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  64
ILE A  62
THR A  60
VAL A  84
LEU A  91
 None
 0.99A 2jn3A-1jjxA:
16.9		 2jn3A-1jjxA:
35.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 107
PHE A 234
ILE A 230
LEU A 226
VAL A 185
 None
 1.28A 2jn3A-1jscA:
undetectable		 2jn3A-1jscA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0v PROTEIN-TYROSINE
PHOSPHATASE YOPH

(Yersinia
pseudotuberculosis) 		PF09013
(YopH_N) 		5 VAL A  66
LEU A   8
VAL A 115
LEU A  76
PHE A  55
 None
 1.25A 2jn3A-1m0vA:
undetectable		 2jn3A-1m0vA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 PHE A 619
ILE A 622
THR A 624
LEU A 260
LEU A 551
 None
 1.13A 2jn3A-1nneA:
undetectable		 2jn3A-1nneA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otg 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE

(Escherichia
coli) 		PF02962
(CHMI) 		5 VAL A  62
PHE A  92
ILE A  88
LEU A  84
LEU A  18
 None
 1.25A 2jn3A-1otgA:
undetectable		 2jn3A-1otgA:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		5 VAL A  49
PHE A  62
ILE A  70
LEU A  89
HIS A  98
 None
 1.00A 2jn3A-1p6pA:
18.3		 2jn3A-1p6pA:
66.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		5 PHE A 107
ILE A 103
LEU A  99
LEU A 119
PHE A 138
 None
None
None
None
ACY  A4011 (-4.6A)
 1.22A 2jn3A-1pp0A:
2.0		 2jn3A-1pp0A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL A 570
ILE A 705
THR A 707
LEU A 665
LEU A 556
 None
 1.22A 2jn3A-1qvrA:
undetectable		 2jn3A-1qvrA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 VAL B 208
ILE B 183
THR B 182
LEU B 257
VAL B 223
 None
 1.25A 2jn3A-1skyB:
undetectable		 2jn3A-1skyB:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		5 PHE A  42
ILE A  43
LEU A  37
LEU A  20
PHE A  30
 None
 1.11A 2jn3A-1suwA:
undetectable		 2jn3A-1suwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x INTEGRIN ALPHA-1

(Rattus
norvegicus) 		PF00092
(VWA) 		5 PHE A 336
ILE A 335
LEU A 331
PHE A 316
HIS A 314
 None
 1.05A 2jn3A-2b2xA:
undetectable		 2jn3A-2b2xA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 VAL A 241
THR A 236
VAL A 232
LEU A 302
PHE A 360
 None
 1.28A 2jn3A-2b42A:
undetectable		 2jn3A-2b42A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egg SHIKIMATE
5-DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ILE A  29
THR A  83
LEU A  28
VAL A  72
LEU A 117
 None
 1.23A 2jn3A-2eggA:
undetectable		 2jn3A-2eggA:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		8 VAL A  49
PHE A  62
ILE A  70
CYH A  80
VAL A  82
LEU A  89
PHE A  96
HIS A  98
 None
None
None
None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
 1.02A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		7 VAL A  49
PHE A  62
THR A  71
CYH A  80
VAL A  82
LEU A  89
HIS A  98
 None
None
None
None
None
None
OLA  A 130 ( 4.8A)
 1.40A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 VAL A 289
PHE A 274
THR A 219
LEU A 230
LEU A 311
 None
 1.24A 2jn3A-2gepA:
undetectable		 2jn3A-2gepA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzf GLUTAREDOXIN-1

(Ectromelia
virus) 		PF00462
(Glutaredoxin) 		5 PHE A  75
THR A  65
VAL A  15
LEU A  33
PHE A  18
 None
 1.09A 2jn3A-2hzfA:
undetectable		 2jn3A-2hzfA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilx 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE

(Rattus
norvegicus) 		PF05881
(CNPase) 		5 VAL A 151
ILE A 106
LEU A 204
VAL A 210
LEU A  14
 None
 1.05A 2jn3A-2ilxA:
undetectable		 2jn3A-2ilxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5t GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01472
(PUA) 		5 VAL A 359
ILE A 288
THR A 366
LEU A 289
VAL A 280
 None
 0.98A 2jn3A-2j5tA:
undetectable		 2jn3A-2j5tA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 VAL A  78
ILE A 108
THR A 144
LEU A 142
PHE A 156
 None
 1.20A 2jn3A-2ji4A:
undetectable		 2jn3A-2ji4A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lcj PAB POLC INTEIN

(Pyrococcus
abyssi) 		PF14890
(Intein_splicing) 		5 PHE A  87
ILE A 177
LEU A  21
THR A  89
HIS A  93
 None
 1.07A 2jn3A-2lcjA:
undetectable		 2jn3A-2lcjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n87 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF00639
(Rotamase) 		5 VAL A 326
LEU A 342
VAL A 366
LEU A 309
PHE A 354
 None
 1.18A 2jn3A-2n87A:
undetectable		 2jn3A-2n87A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p26 INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin) 		5 VAL A 358
PHE A 404
ILE A 406
LEU A  76
LEU A  83
 None
 1.23A 2jn3A-2p26A:
undetectable		 2jn3A-2p26A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p26 INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin) 		5 VAL A 358
PHE A 404
LEU A  76
VAL A 417
LEU A  83
 None
 1.16A 2jn3A-2p26A:
undetectable		 2jn3A-2p26A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ILE A 323
THR A 321
LYS A  16
LEU A  18
VAL A  30
 None
 1.28A 2jn3A-2pljA:
undetectable		 2jn3A-2pljA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF03466
(LysR_substrate) 		5 VAL A 301
ILE A 155
LEU A 111
CYH A 107
VAL A 105
 None
 1.29A 2jn3A-2ql3A:
undetectable		 2jn3A-2ql3A:
18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 PHE A  62
ILE A  70
THR A  72
VAL A  82
HIS A  98
 IPA  A 142 ( 4.4A)
IPA  A 141 ( 4.5A)
GOL  A 145 (-3.2A)
None
IPA  A 140 (-3.7A)
 0.67A 2jn3A-2qo4A:
21.0		 2jn3A-2qo4A:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qos COMPLEMENT COMPONENT
8, GAMMA POLYPEPTIDE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 VAL C  57
PHE C  27
THR C  62
VAL C 107
LEU C 118
 None
 1.15A 2jn3A-2qosC:
3.0		 2jn3A-2qosC:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ubp PROTEIN (UREASE BETA
SUBUNIT)

(Sporosarcina
pasteurii) 		PF00699
(Urease_beta) 		5 VAL B  85
PHE B  48
THR B  73
VAL B  51
LEU B  55
 None
 1.25A 2jn3A-2ubpB:
undetectable		 2jn3A-2ubpB:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		5 VAL A 187
PHE A 307
ILE A 182
THR A 166
HIS A 168
 None
 1.18A 2jn3A-2wamA:
undetectable		 2jn3A-2wamA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		5 VAL A 210
PHE A 212
VAL A 183
LEU A 143
THR A 131
 None
 1.22A 2jn3A-2xj9A:
undetectable		 2jn3A-2xj9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 VAL A 308
PHE A 296
THR A 324
VAL A 294
LEU A 340
 None
 1.28A 2jn3A-2yocA:
undetectable		 2jn3A-2yocA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 PHE A 256
ILE A 261
LEU A 289
LEU A 273
PHE A 295
 None
 1.01A 2jn3A-2z7xA:
undetectable		 2jn3A-2z7xA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		5 ILE A  28
LEU A  53
CYH A  23
LEU A  90
PHE A 107
 None
 1.19A 2jn3A-3cerA:
undetectable		 2jn3A-3cerA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		5 VAL C1595
ILE C1686
LEU C1674
VAL C1647
LEU C1603
 None
 1.19A 2jn3A-3dqvC:
undetectable		 2jn3A-3dqvC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 VAL A 464
PHE A 466
THR A 448
LEU A 480
THR A 430
 None
 1.15A 2jn3A-3eh2A:
undetectable		 2jn3A-3eh2A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2i ALR0221 PROTEIN

(Nostoc sp. PCC
7120) 		PF00300
(His_Phos_1) 		5 PHE A  47
ILE A  50
THR A  52
LEU A  74
LEU A  40
 None
 1.15A 2jn3A-3f2iA:
undetectable		 2jn3A-3f2iA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 VAL A 214
ILE A 372
LEU A 376
VAL A 221
HIS A  -5
 PO4  A 501 (-4.0A)
None
None
None
ZN  A 800 (-3.1A)
 1.14A 2jn3A-3k6jA:
undetectable		 2jn3A-3k6jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		5 PHE A 203
ILE A 204
LEU A  94
LEU A 192
PHE A   9
 None
 1.14A 2jn3A-3kzxA:
undetectable		 2jn3A-3kzxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 VAL A 214
ILE A 115
THR A  83
VAL A 187
LEU A  10
 None
None
None
MLY  A 185 ( 4.6A)
MLY  A   9 ( 4.1A)
 1.25A 2jn3A-3ln3A:
undetectable		 2jn3A-3ln3A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mah ASPARTOKINASE

(Porphyromonas
gingivalis) 		PF13840
(ACT_7) 		5 VAL A 338
THR A 308
LYS A 375
VAL A 348
LEU A 327
 None
 1.19A 2jn3A-3mahA:
undetectable		 2jn3A-3mahA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no3 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		5 VAL A 144
PHE A 122
LEU A  47
VAL A  62
LEU A  70
 None
 1.25A 2jn3A-3no3A:
undetectable		 2jn3A-3no3A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM

([Ruminococcus]
gnavus) 		PF01551
(Peptidase_M23) 		5 ILE A 157
THR A 155
LEU A 265
VAL A 169
LEU A 205
 None
 1.22A 2jn3A-3nyyA:
undetectable		 2jn3A-3nyyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odo RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		5 PHE A 725
ILE A 755
THR A 758
LEU A 710
LEU A 654
 None
 1.14A 2jn3A-3odoA:
undetectable		 2jn3A-3odoA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ose SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF02149
(KA1) 		5 VAL A 724
LYS A 783
VAL A 770
LEU A 795
THR A 708
 None
 1.09A 2jn3A-3oseA:
undetectable		 2jn3A-3oseA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 VAL A 213
THR A 300
LEU A 296
VAL A 224
LEU A 200
 None
 1.22A 2jn3A-3pdiA:
undetectable		 2jn3A-3pdiA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 VAL A 290
ILE A 266
VAL A 268
LEU A 250
PHE A 217
 None
 1.10A 2jn3A-3pg8A:
undetectable		 2jn3A-3pg8A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0i METHIONYL-TRNA
FORMYLTRANSFERASE

(Vibrio cholerae) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 VAL A  89
ILE A 139
LEU A 152
CYH A 183
LEU A  23
 None
 1.24A 2jn3A-3q0iA:
undetectable		 2jn3A-3q0iA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qn3 ENOLASE

(Campylobacter
jejuni) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		6 VAL A  70
ILE A  78
THR A  92
LEU A  81
VAL A  25
THR A 117
 None
 1.34A 2jn3A-3qn3A:
undetectable		 2jn3A-3qn3A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1

(Homo sapiens) 		PF00617
(RasGEF) 		5 VAL A  46
PHE A 125
ILE A 128
LEU A 132
VAL A 105
 None
 1.24A 2jn3A-3qxlA:
undetectable		 2jn3A-3qxlA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 VAL A 498
THR A 337
LEU A 459
LEU A 490
PHE A 416
 None
 1.15A 2jn3A-3ue3A:
undetectable		 2jn3A-3ue3A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		5 VAL A  19
PHE A  34
VAL A  38
LEU A  42
THR A 139
 None
 1.19A 2jn3A-3vzbA:
undetectable		 2jn3A-3vzbA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 VAL A 189
PHE A 185
THR A 121
LEU A 155
VAL A 169
 None
 1.22A 2jn3A-3zyxA:
undetectable		 2jn3A-3zyxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 VAL A  38
ILE A  92
VAL A 120
LEU A 271
THR A 275
 None
 1.03A 2jn3A-4a5oA:
undetectable		 2jn3A-4a5oA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		5 VAL A 114
ILE A 164
LEU A 191
VAL A 186
PHE A 209
 None
 1.27A 2jn3A-4c2lA:
undetectable		 2jn3A-4c2lA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		5 ILE A 776
THR A 689
VAL A 736
LEU A 768
PHE A 764
 None
 1.26A 2jn3A-4fc2A:
undetectable		 2jn3A-4fc2A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fu0 D-ALANINE--D-ALANINE
LIGASE 7

(Enterococcus
faecalis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 VAL A  27
PHE A 102
ILE A   6
VAL A 127
LEU A 343
 None
 1.21A 2jn3A-4fu0A:
undetectable		 2jn3A-4fu0A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 VAL A 289
PHE A 274
THR A 219
LEU A 230
LEU A 311
 None
 1.26A 2jn3A-4g38A:
undetectable		 2jn3A-4g38A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		6 ILE A 115
THR A 117
LEU A 103
CYH A 105
LEU A  69
THR A  71
 None
 1.36A 2jn3A-4gq1A:
2.0		 2jn3A-4gq1A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwo PHOSPHATE BINDING
PROTEIN

(Planctopirus
limnophila) 		PF12727
(PBP_like) 		5 VAL A 136
ILE A 301
THR A 287
LYS A 291
VAL A  75
 None
 1.26A 2jn3A-4jwoA:
undetectable		 2jn3A-4jwoA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 VAL A  57
ILE A 233
THR A 235
LEU A  30
LEU A 396
 None
 1.21A 2jn3A-4lr2A:
undetectable		 2jn3A-4lr2A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzk PIXA INCLUSION BODY
PROTEIN

(Burkholderia
cenocepacia) 		PF12306
(PixA) 		5 VAL A  79
PHE A 111
VAL A  99
LEU A 155
THR A 157
 None
 1.05A 2jn3A-4lzkA:
undetectable		 2jn3A-4lzkA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 PHE A 478
ILE A 303
LEU A 304
LEU A 559
PHE A 656
 None
 1.15A 2jn3A-4n2cA:
undetectable		 2jn3A-4n2cA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nvr PUTATIVE
ACYLTRANSFERASE

(Salmonella
enterica) 		PF00561
(Abhydrolase_1) 		5 PHE A 110
LEU A 300
CYH A 135
VAL A 133
LEU A 125
 None
 1.21A 2jn3A-4nvrA:
undetectable		 2jn3A-4nvrA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rma EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 VAL A  42
THR A  36
LEU A  16
LEU A  61
PHE A  18
 None
 1.24A 2jn3A-4rmaA:
undetectable		 2jn3A-4rmaA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvo PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
thetaiotaomicron) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 VAL A 247
PHE A 259
LEU A  18
VAL A 266
LEU A 287
 None
 1.25A 2jn3A-4rvoA:
undetectable		 2jn3A-4rvoA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zy7 UNCHARACTERIZED
PROTEIN MSMEG_5817

(Mycolicibacterium
smegmatis) 		no annotation 5 VAL A 117
THR A  43
LEU A  91
VAL A 107
THR A  85
 None
 0.91A 2jn3A-4zy7A:
undetectable		 2jn3A-4zy7A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 VAL A  54
PHE A  67
THR A  77
VAL A  87
LEU A  95
 None
 0.81A 2jn3A-5bvtA:
18.8		 2jn3A-5bvtA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ILE A 397
LEU A 391
CYH A 393
LEU A 475
HIS A 479
 GOL  A 607 (-4.5A)
None
None
None
None
 1.28A 2jn3A-5c4tA:
undetectable		 2jn3A-5c4tA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)

(synthetic
construct) 		PF00079
(Serpin) 		5 VAL A 358
PHE A 342
ILE A 224
LEU A 212
LEU A 309
 None
 1.07A 2jn3A-5ce0A:
1.0		 2jn3A-5ce0A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 ILE B 277
THR B 260
LEU B 314
VAL B 274
LEU B 236
 None
 0.91A 2jn3A-5do8B:
undetectable		 2jn3A-5do8B:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU B   4
CYH B  92
VAL B  37
LEU B  47
HIS B  35
 None
 1.13A 2jn3A-5f9wB:
undetectable		 2jn3A-5f9wB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		5 VAL A 253
ILE A 248
THR A 243
LYS A 245
LEU A  52
 None
 1.28A 2jn3A-5fjnA:
undetectable		 2jn3A-5fjnA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hon EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF13385
(Laminin_G_3) 		5 ILE A 767
THR A 769
LEU A 721
LEU A 714
THR A 727
 None
 1.09A 2jn3A-5honA:
undetectable		 2jn3A-5honA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		5 ILE A 767
THR A 769
LEU A 721
LEU A 714
THR A 727
 None
 1.00A 2jn3A-5hp6A:
undetectable		 2jn3A-5hp6A:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ILE A 378
THR A 402
LEU A 400
LEU A 326
PHE A 247
 None
 1.20A 2jn3A-5i1wA:
undetectable		 2jn3A-5i1wA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 ILE A 335
LEU A 337
CYH A 372
LEU A 353
THR A 368
 None
 1.27A 2jn3A-5ikpA:
undetectable		 2jn3A-5ikpA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 PHE A 269
ILE A 280
THR A 282
LEU A  12
THR A 123
 None
None
None
None
FAD  A 500 (-3.8A)
 1.14A 2jn3A-5jcnA:
undetectable		 2jn3A-5jcnA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A

(Danio rerio) 		PF00656
(Peptidase_C14) 		5 VAL A 118
PHE A 162
THR A 143
LYS A 140
LEU A 237
 None
None
MRD  A 302 (-4.0A)
MRD  A 302 (-3.6A)
None
 1.03A 2jn3A-5jftA:
undetectable		 2jn3A-5jftA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 VAL A 439
PHE A 467
THR A 488
VAL A 472
LEU A 474
 None
 1.28A 2jn3A-5lm8A:
undetectable		 2jn3A-5lm8A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  82
PHE A  29
ILE A  35
LEU A  64
VAL A  28
 None
 0.97A 2jn3A-5mdhA:
undetectable		 2jn3A-5mdhA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 5 VAL A 527
PHE A 529
THR A 468
VAL A 535
LEU A 537
 None
 1.23A 2jn3A-5ny0A:
undetectable		 2jn3A-5ny0A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 VAL A 538
PHE A  45
THR A  60
LEU A 111
LEU A  70
 None
 1.19A 2jn3A-5tqrA:
undetectable		 2jn3A-5tqrA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 THR A 398
VAL A 115
LEU A  77
THR A  79
PHE A 402
 GOL  A 503 (-3.9A)
None
None
None
None
 1.20A 2jn3A-5tvjA:
undetectable		 2jn3A-5tvjA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		5 PHE A 543
THR A 548
LEU A 602
LEU A 500
PHE A 591
 None
 1.08A 2jn3A-5txeA:
3.2		 2jn3A-5txeA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 VAL A  62
ILE A 242
THR A 244
LEU A  35
LEU A 413
 None
None
None
None
IOD  A 521 ( 4.6A)
 1.20A 2jn3A-5udyA:
undetectable		 2jn3A-5udyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 VAL A  59
ILE A 234
THR A 236
LEU A  32
LEU A 399
 None
 1.02A 2jn3A-5vemA:
undetectable		 2jn3A-5vemA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 5 ILE C  26
LEU C  84
CYH C  27
LEU C 531
PHE C 629
 None
 1.24A 2jn3A-5x6xC:
undetectable		 2jn3A-5x6xC:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 491
PHE A 511
ILE A 475
VAL A 470
LEU A 466
 None
 1.01A 2jn3A-6az0A:
undetectable		 2jn3A-6az0A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 5 VAL A 131
THR A 125
LEU A 182
THR A   6
HIS A   5
 None
 1.29A 2jn3A-6fuyA:
undetectable		 2jn3A-6fuyA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au1 INTERFERON-BETA

(Homo sapiens) 		PF00143
(Interferon) 		4 LEU A  87
ASN A 158
ILE A  66
PHE A  70
 None
 1.16A 2jn3A-1au1A:
0.0		 2jn3A-1au1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgf STAT-4

(Mus musculus) 		PF02865
(STAT_int) 		4 LEU A  60
ASN A 107
GLN A   3
ILE A  38
 None
 1.18A 2jn3A-1bgfA:
0.0		 2jn3A-1bgfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb1 CALBINDIN D9K

(Sus scrofa) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		4 LEU A  49
LYS A  29
GLN A   0
ILE A  73
 None
 1.08A 2jn3A-1cb1A:
undetectable		 2jn3A-1cb1A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER

(Thermochromatium
tepidum) 		PF00124
(Photo_RC) 		4 LEU L 139
ASN L 178
GLN L 171
PHE L 154
 BCL  L 602 (-4.4A)
None
None
BCL  L 604 (-3.5A)
 1.21A 2jn3A-1eysL:
0.0		 2jn3A-1eysL:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipk BETA-CONGLYCININ,
BETA CHAIN

(Glycine max) 		PF00190
(Cupin_1)
PF07883
(Cupin_2) 		4 LEU A 125
ASN A  37
ILE A 340
PHE A 338
 None
 0.99A 2jn3A-1ipkA:
0.3		 2jn3A-1ipkA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1

(Neisseria
gonorrhoeae) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 LEU A 216
GLN A 171
ILE A 169
PHE A 167
 None
 1.13A 2jn3A-1kbvA:
0.0		 2jn3A-1kbvA:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		4 LEU A  93
LYS A   1
ILE A  42
PHE A   4
 None
 1.24A 2jn3A-1kqxA:
18.3		 2jn3A-1kqxA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7p PHOSPHOSERINE
PHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF12710
(HAD) 		4 LEU A 203
LYS A 200
ILE A 182
PHE A 184
 None
 1.24A 2jn3A-1l7pA:
0.0		 2jn3A-1l7pA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 LEU A 151
ASN B 266
GLN B 194
ILE B 191
 None
 1.23A 2jn3A-1m1jA:
undetectable		 2jn3A-1m1jA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmf IGG2A-KAPPA R6.5 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  86
LYS H  67
GLN H   6
ILE H  20
 None
 1.18A 2jn3A-1rmfH:
undetectable		 2jn3A-1rmfH:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg3 ALLANTOICASE

(Saccharomyces
cerevisiae) 		PF03561
(Allantoicase) 		4 LEU A  48
ASN A 108
GLN A 147
ILE A 100
 None
 1.19A 2jn3A-1sg3A:
undetectable		 2jn3A-1sg3A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		4 LEU A 208
GLN A 168
ILE A 173
PHE A 242
 None
 0.83A 2jn3A-1t5eA:
undetectable		 2jn3A-1t5eA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		4 LEU A1679
GLN A1739
ILE A1672
PHE A1675
 None
 0.87A 2jn3A-1u4qA:
undetectable		 2jn3A-1u4qA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		4 LEU B 410
ASN A 151
ILE B 390
PHE B 397
 None
 1.24A 2jn3A-1w2wB:
undetectable		 2jn3A-1w2wB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		4 LEU A 228
ASN A 310
GLN A 303
ILE A 322
 None
 1.09A 2jn3A-1x9yA:
undetectable		 2jn3A-1x9yA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		4 LEU A 124
LYS A 108
GLN A 138
ILE A 115
 None
 1.18A 2jn3A-1xr4A:
undetectable		 2jn3A-1xr4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		4 LEU A 151
ASN A 203
LYS A 127
ILE A  27
 None
 1.22A 2jn3A-1xzzA:
undetectable		 2jn3A-1xzzA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 LEU A 102
ASN A 163
LYS A 329
PHE A 333
 None
 0.99A 2jn3A-1zl6A:
undetectable		 2jn3A-1zl6A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvy IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		4 LEU A 109
LYS A  65
GLN A  72
ILE A  70
 None
 1.15A 2jn3A-1zvyA:
undetectable		 2jn3A-1zvyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c27 MYCOTHIOL SYNTHASE

(Mycobacterium
tuberculosis) 		PF00583
(Acetyltransf_1) 		4 LEU A 204
ASN A 171
GLN A 245
PHE A 206
 None
None
COA  A1314 (-3.5A)
None
 1.17A 2jn3A-2c27A:
undetectable		 2jn3A-2c27A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crf RAN BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		4 LEU A  36
ASN A  57
ILE A 103
PHE A 116
 None
 1.21A 2jn3A-2crfA:
undetectable		 2jn3A-2crfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1m ACRIFLAVINE
RESISTANCE PROTEIN A

(Escherichia
coli) 		PF16576
(HlyD_D23) 		4 LEU A 246
GLN A 207
ILE A 212
PHE A 280
 None
 0.78A 2jn3A-2f1mA:
undetectable		 2jn3A-2f1mA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 437
ASN A 161
GLN A 453
ILE A 471
 None
 1.17A 2jn3A-2isaA:
1.0		 2jn3A-2isaA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgn ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00271
(Helicase_C) 		4 LEU A 456
ASN A 435
ILE A 513
PHE A 515
 None
 0.89A 2jn3A-2jgnA:
undetectable		 2jn3A-2jgnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli) 		PF00781
(DAGK_cat) 		4 LEU A 223
ASN A 137
ILE A 280
PHE A 256
 None
 1.20A 2jn3A-2jgrA:
undetectable		 2jn3A-2jgrA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llf VILLIN-1

(Gallus gallus) 		PF00626
(Gelsolin) 		4 LEU A  33
ASN A   8
ILE A  44
PHE A  42
 None
 1.23A 2jn3A-2llfA:
undetectable		 2jn3A-2llfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		4 LEU A 585
ASN A 574
GLN A 534
ILE A 561
 None
 0.95A 2jn3A-2v5iA:
3.4		 2jn3A-2v5iA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfo GLYCOPROTEIN 1

(Machupo
mammarenavirus) 		PF00798
(Arena_glycoprot) 		4 LEU A 152
ASN A  96
ILE A 179
PHE A 177
 None
 1.21A 2jn3A-2wfoA:
undetectable		 2jn3A-2wfoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 LEU A 305
GLN A 338
ILE A 298
PHE A 301
 None
 1.07A 2jn3A-2xijA:
undetectable		 2jn3A-2xijA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8f RAN-BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		4 LEU A 340
ASN A 361
ILE A 407
PHE A 420
 None
 1.08A 2jn3A-2y8fA:
1.4		 2jn3A-2y8fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 584
ASN A 565
GLN A 524
PHE A 608
 None
 1.21A 2jn3A-3dduA:
undetectable		 2jn3A-3dduA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 LEU B  98
ASN B 371
GLN B  43
PHE B  99
 None
 1.24A 2jn3A-3draB:
undetectable		 2jn3A-3draB:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 182
ASN A 224
ILE A 241
PHE A 215
 None
 1.06A 2jn3A-3ekgA:
0.2		 2jn3A-3ekgA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 521
ASN A 689
LYS A 535
PHE A 532
 None
 1.23A 2jn3A-3fn9A:
undetectable		 2jn3A-3fn9A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 LEU A 313
ASN A 319
GLN A 270
PHE A 281
 LEU  A 313 ( 0.5A)
ASN  A 319 ( 0.6A)
GLN  A 270 ( 0.6A)
PHE  A 281 ( 1.3A)
 1.21A 2jn3A-3gnrA:
undetectable		 2jn3A-3gnrA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 LEU A 207
LYS A 236
GLN A 225
ILE A 229
 None
 1.07A 2jn3A-3hlmA:
undetectable		 2jn3A-3hlmA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ica PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Porphyromonas
gingivalis) 		no annotation 4 LEU A  63
ASN A  73
GLN A 197
PHE A 201
 None
GOL  A 214 ( 4.8A)
None
None
 1.23A 2jn3A-3icaA:
undetectable		 2jn3A-3icaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igq GLR4197 PROTEIN

(Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		4 LEU A  24
GLN A 193
ILE A 162
PHE A 165
 HG  A 700 ( 3.9A)
None
None
None
 0.97A 2jn3A-3igqA:
undetectable		 2jn3A-3igqA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		4 LEU D 393
ASN D   9
GLN D 498
ILE D 502
 None
 0.91A 2jn3A-3j9eD:
1.9		 2jn3A-3j9eD:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		4 LEU A 523
ASN A 514
LYS A 576
PHE A 580
 None
 1.15A 2jn3A-3javA:
undetectable		 2jn3A-3javA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kip 3-DEHYDROQUINASE,
TYPE II

(Candida
albicans) 		PF01220
(DHquinase_II) 		4 LEU A  92
GLN A  52
ILE A   7
PHE A  99
 None
 1.15A 2jn3A-3kipA:
undetectable		 2jn3A-3kipA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		4 LEU A 324
GLN A 271
ILE A 251
PHE A 252
 None
 0.96A 2jn3A-3ktcA:
undetectable		 2jn3A-3ktcA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes) 		PF01244
(Peptidase_M19) 		4 LEU A 272
ASN A  32
ILE A 265
PHE A 224
 None
 1.14A 2jn3A-3lu2A:
undetectable		 2jn3A-3lu2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2p UDP-N-ACETYLGLUCOSAM
INE 4-EPIMERASE

(Bacillus cereus) 		PF01370
(Epimerase) 		4 LEU A 272
LYS A 154
ILE A 222
PHE A 220
 None
 1.14A 2jn3A-3m2pA:
undetectable		 2jn3A-3m2pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0z ADENYLATE CYCLASE 2

(Yersinia pestis) 		PF01928
(CYTH) 		4 ASN A 159
LYS A 120
GLN A  26
ILE A 123
 None
 1.07A 2jn3A-3n0zA:
2.3		 2jn3A-3n0zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4c DE NOVO DESIGNED
BETA-TREFOIL
ARCHITECTURE WITH
SYMMETRIC PRIMARY
STRUCTURE

(synthetic
construct) 		PF00167
(FGF) 		4 LEU A  23
ASN A  68
GLN A  84
PHE A 132
 None
 1.14A 2jn3A-3o4cA:
undetectable		 2jn3A-3o4cA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6c PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		PF03740
(PdxJ) 		4 LEU A  71
ASN A  66
GLN A 144
ILE A 114
 None
 1.24A 2jn3A-3o6cA:
undetectable		 2jn3A-3o6cA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7t CYCLOPHILIN A

(Moniliophthora
perniciosa) 		PF00160
(Pro_isomerase) 		4 LEU A 134
ASN A   3
LYS A  92
ILE A 112
 None
 1.23A 2jn3A-3o7tA:
undetectable		 2jn3A-3o7tA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ory FLAP ENDONUCLEASE 1

(Desulfurococcus
amylolyticus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 LEU A 272
ASN A 229
ILE A 249
PHE A 246
 None
 1.20A 2jn3A-3oryA:
undetectable		 2jn3A-3oryA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 ASN A 404
GLN A 467
ILE A 356
PHE A 354
 EDO  A 477 ( 4.7A)
None
None
None
 1.10A 2jn3A-3rc0A:
undetectable		 2jn3A-3rc0A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  31
GLN A 164
ILE A  88
PHE A  91
 None
 1.17A 2jn3A-3rg2A:
undetectable		 2jn3A-3rg2A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svi TYPE III EFFECTOR
HOPAB2

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 LEU A 208
ASN A 184
ILE A 163
PHE A 167
 None
CL  A   3 (-3.5A)
None
None
 1.24A 2jn3A-3sviA:
undetectable		 2jn3A-3sviA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		4 ASN A 172
GLN A 124
ILE A 135
PHE A 134
 None
 1.16A 2jn3A-3td9A:
undetectable		 2jn3A-3td9A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tni CYCLIN-T1

(Homo sapiens) 		PF00134
(Cyclin_N) 		4 LEU B 241
ASN B  43
GLN B  56
PHE B 187
 None
 1.24A 2jn3A-3tniB:
undetectable		 2jn3A-3tniB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 LYS A1174
GLN A1119
ILE A1229
PHE A1223
 None
 0.93A 2jn3A-3u44A:
undetectable		 2jn3A-3u44A:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 113
ASN A 211
GLN A 218
PHE A 172
 None
 1.24A 2jn3A-3vi3A:
undetectable		 2jn3A-3vi3A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh9 DELTA

(Bacillus
subtilis) 		PF06144
(DNA_pol3_delta) 		4 LEU B 333
GLN B 217
ILE B 237
PHE B 238
 None
 1.21A 2jn3A-3zh9B:
undetectable		 2jn3A-3zh9B:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 157
ASN A 218
ILE A 237
PHE A 230
 None
FM6  A 501 (-3.4A)
None
None
 1.16A 2jn3A-3zhyA:
undetectable		 2jn3A-3zhyA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		4 LEU A 134
ASN A 209
GLN A  87
ILE A  68
 None
None
AZM  A 302 (-4.4A)
None
 1.22A 2jn3A-4g7aA:
1.2		 2jn3A-4g7aA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 207
ASN A 148
ILE A 216
PHE A 219
 None
 1.21A 2jn3A-4hpnA:
undetectable		 2jn3A-4hpnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		4 LEU A 376
GLN A 621
ILE A 406
PHE A 404
 None
 1.03A 2jn3A-4hsuA:
undetectable		 2jn3A-4hsuA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l95 GAMMA-GLUTAMYL
HYDROLASE

(Danio rerio) 		no annotation 4 LEU E  93
ASN E 181
ILE E 212
PHE E 210
 None
 1.19A 2jn3A-4l95E:
undetectable		 2jn3A-4l95E:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mli FIBRONECTIN BINDING
PROTEIN

(Streptococcus
pyogenes) 		PF02986
(Fn_bind) 		4 LEU A  46
ASN A 103
ILE A  27
PHE A  66
 None
 1.17A 2jn3A-4mliA:
undetectable		 2jn3A-4mliA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ole NEXT TO BRCA1 GENE 1
PROTEIN

(Homo sapiens) 		PF16158
(N_BRCA1_IG) 		4 LEU A 419
LYS A 394
GLN A 387
PHE A 446
 None
 1.04A 2jn3A-4oleA:
undetectable		 2jn3A-4oleA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Bacillus
subtilis) 		no annotation 4 LEU A  49
ASN A  16
GLN A   7
ILE A   2
 None
 1.02A 2jn3A-4p8iA:
undetectable		 2jn3A-4p8iA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 LEU A 136
ASN A 189
GLN A 171
ILE A 150
 None
 1.11A 2jn3A-4p8sA:
undetectable		 2jn3A-4p8sA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdy PARATHION HYDROLASE

(Vulcanisaeta
moutnovskia) 		PF02126
(PTE) 		4 ASN A 176
GLN A 212
ILE A 183
PHE A 186
 None
None
GOL  A 407 ( 4.2A)
None
 1.22A 2jn3A-4rdyA:
undetectable		 2jn3A-4rdyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Gloeobacter
violaceus;
Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 LEU A  24
GLN A 219
ILE A 162
PHE A 165
 None
 1.06A 2jn3A-4x5tA:
undetectable		 2jn3A-4x5tA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycs UNCHARACTERIZED
PROTEIN

(Clostridioides
difficile) 		PF02608
(Bmp) 		4 ASN A  85
GLN A 131
ILE A  99
PHE A  95
 None
 1.07A 2jn3A-4ycsA:
undetectable		 2jn3A-4ycsA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjg ALPHA-2-MACROGLOBULI
N

(Escherichia
coli) 		PF11974
(MG1) 		4 LEU A  83
LYS A 157
GLN A  95
ILE A 101
 None
PG4  A 401 (-2.8A)
None
None
 1.13A 2jn3A-4zjgA:
undetectable		 2jn3A-4zjgA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 142
ASN A 104
ILE A  82
PHE A  80
 None
SO4  A 806 (-3.1A)
None
None
 0.95A 2jn3A-4zlgA:
0.8		 2jn3A-4zlgA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		4 ASN A 264
GLN A 154
ILE A 184
PHE A 176
 None
 1.12A 2jn3A-5a08A:
undetectable		 2jn3A-5a08A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 LEU A 281
ASN A 249
ILE A 207
PHE A 183
 None
 1.20A 2jn3A-5dl7A:
1.8		 2jn3A-5dl7A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 LEU B 452
ASN B  21
ILE B 369
PHE B 459
 None
 0.75A 2jn3A-5do8B:
undetectable		 2jn3A-5do8B:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1

(Fervidobacterium
islandicum) 		PF02074
(Peptidase_M32) 		4 LEU A 204
ASN A 327
ILE A 244
PHE A 200
 None
 1.16A 2jn3A-5e3xA:
undetectable		 2jn3A-5e3xA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 457
ASN A 436
ILE A 514
PHE A 516
 None
 0.89A 2jn3A-5e7jA:
undetectable		 2jn3A-5e7jA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 LEU A2258
ASN A2204
GLN A2213
ILE A2215
 None
 1.22A 2jn3A-5fu7A:
undetectable		 2jn3A-5fu7A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 4 LEU I  60
ASN I  66
GLN I  31
ILE I  53
 None
 1.16A 2jn3A-5furI:
undetectable		 2jn3A-5furI:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU B 470
ASN B 522
ILE B 485
PHE B 461
 None
 0.94A 2jn3A-5gqrB:
undetectable		 2jn3A-5gqrB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		4 ASN A 324
GLN A  56
ILE A  63
PHE A  96
 None
 1.03A 2jn3A-5gvvA:
undetectable		 2jn3A-5gvvA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl3 LMO2470 PROTEIN

(Listeria
monocytogenes) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 LEU A 266
ASN A 233
GLN A 292
ILE A 287
 None
 1.24A 2jn3A-5hl3A:
undetectable		 2jn3A-5hl3A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		4 LEU A 171
ASN A  90
LYS A 158
ILE A 184
 None
 1.15A 2jn3A-5izdA:
undetectable		 2jn3A-5izdA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 4 ASN A  18
GLN A 123
ILE A 192
PHE A 191
 None
None
None
AKG  A 301 (-4.1A)
 1.17A 2jn3A-5j4rA:
undetectable		 2jn3A-5j4rA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 LEU A 256
ASN A 313
GLN A  42
ILE A 267
 None
 1.22A 2jn3A-5kucA:
undetectable		 2jn3A-5kucA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU B 261
GLN B  53
ILE A  54
PHE A  50
 None
 1.17A 2jn3A-5mkkB:
undetectable		 2jn3A-5mkkB:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 4 LEU A  44
ASN A 143
ILE A  22
PHE A  31
 None
 1.24A 2jn3A-5n7qA:
undetectable		 2jn3A-5n7qA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 LEU A 363
ASN A  57
GLN A 347
ILE A 350
 None
NAG  A1101 (-1.8A)
None
None
 1.19A 2jn3A-5nbsA:
undetectable		 2jn3A-5nbsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA

(Escherichia
coli) 		no annotation 4 LEU E 246
GLN E 207
ILE E 212
PHE E 280
 None
 0.93A 2jn3A-5ng5E:
undetectable		 2jn3A-5ng5E:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 4 LEU A  61
ASN A 355
ILE A 374
PHE A 378
 None
 1.13A 2jn3A-5o82A:
0.8		 2jn3A-5o82A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Gloeobacter
violaceus;
Mus musculus) 		no annotation 4 LEU A  23
GLN A 192
ILE A 161
PHE A 164
 None
 1.11A 2jn3A-5osbA:
undetectable		 2jn3A-5osbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tta PUTATIVE EXPORTED
PROTEIN

(Clostridioides
difficile) 		no annotation 4 LEU A  67
LYS A 162
GLN A  75
ILE A  88
 None
 1.16A 2jn3A-5ttaA:
undetectable		 2jn3A-5ttaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2u HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		PF02861
(Clp_N) 		4 LEU A 117
ASN A  70
ILE A 126
PHE A 121
 None
 1.01A 2jn3A-5u2uA:
undetectable		 2jn3A-5u2uA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 4 LEU C  24
GLN C 193
ILE C 162
PHE C 165
 None
 1.07A 2jn3A-5v6nC:
undetectable		 2jn3A-5v6nC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wan PYRIMIDINE
MONOOXYGENASE RUTA

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		4 LEU A 329
ASN A  65
GLN A 122
PHE A 206
 None
None
None
FMN  A 409 ( 4.5A)
 1.16A 2jn3A-5wanA:
undetectable		 2jn3A-5wanA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 LEU A 996
ASN A1014
GLN A1021
ILE A1062
 None
 0.90A 2jn3A-5wlhA:
undetectable		 2jn3A-5wlhA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x47 3-DEHYDROQUINATE
DEHYDRATASE

(Acinetobacter
baumannii) 		PF01220
(DHquinase_II) 		4 LEU A  91
GLN A  51
ILE A   8
PHE A  98
 None
 1.13A 2jn3A-5x47A:
undetectable		 2jn3A-5x47A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 LEU A 529
ASN A 419
GLN A 504
ILE A 539
 None
 1.23A 2jn3A-5x7hA:
undetectable		 2jn3A-5x7hA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 4 LYS A 209
GLN A 124
ILE A 180
PHE A 205
 None
None
MTA  A 401 (-3.6A)
None
 1.17A 2jn3A-5xncA:
undetectable		 2jn3A-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A  33
GLN A  23
ILE A  21
PHE A  19
 None
 1.12A 2jn3A-6c6lA:
undetectable		 2jn3A-6c6lA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 LEU D 666
LYS D  52
GLN D 302
PHE D  53
 None
None
EDO  D 705 (-3.6A)
None
 1.12A 2jn3A-6eq8D:
undetectable		 2jn3A-6eq8D:
22.05