SIMILAR PATTERNS OF AMINO ACIDS FOR 2JN3_A_JN3A130_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LEU A 174
PRO A 209
GLU A 438
ARG A 213
 None
 1.04A 2jn3A-1a2vA:
1.4		 2jn3A-1a2vA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A  45
LEU A 396
GLU A 259
ARG A  52
 None
 0.92A 2jn3A-1atiA:
0.0		 2jn3A-1atiA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Thermotoga
maritima) 		PF00121
(TIM) 		4 PHE A 190
LEU A 194
LEU A 195
GLU A 130
 None
 0.95A 2jn3A-1b9bA:
undetectable		 2jn3A-1b9bA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		4 LEU A  23
LEU A 117
GLU A  70
ARG A  89
 None
 0.63A 2jn3A-1cbfA:
0.0		 2jn3A-1cbfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 LEU A 380
LEU A 393
ARG A 121
GLU A 160
 None
 0.96A 2jn3A-1crzA:
0.0		 2jn3A-1crzA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 PHE A  10
LEU A  91
LEU A  98
PRO A 167
ARG A  72
 None
 1.41A 2jn3A-1e4oA:
undetectable		 2jn3A-1e4oA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens) 		PF01291
(LIF_OSM) 		4 PHE A  70
LEU A  14
GLU A  59
ARG A  63
 None
 0.94A 2jn3A-1evsA:
undetectable		 2jn3A-1evsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fgg GLUCURONYLTRANSFERAS
E I

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 PHE A 204
LEU A 100
LEU A 130
ARG A 201
 None
 0.99A 2jn3A-1fggA:
undetectable		 2jn3A-1fggA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw1 GLUTATHIONE
TRANSFERASE ZETA

(Homo sapiens) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		4 PHE A 139
LEU A 142
LEU A 146
GLU A 174
 None
 1.04A 2jn3A-1fw1A:
undetectable		 2jn3A-1fw1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A  45
LEU A 396
GLU A 259
ARG A  52
 None
 1.06A 2jn3A-1ggmA:
0.8		 2jn3A-1ggmA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 PHE A 557
LEU A 470
ARG A 583
GLU A 452
 None
 0.94A 2jn3A-1h17A:
undetectable		 2jn3A-1h17A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34

(Pisum sativum) 		PF04548
(AIG1) 		4 PHE A  17
LEU A  25
LEU A  26
GLU A  62
 None
 0.92A 2jn3A-1h65A:
undetectable		 2jn3A-1h65A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 LEU A 819
LEU A 797
GLU A 782
ARG A 692
 None
 0.79A 2jn3A-1hn0A:
2.6		 2jn3A-1hn0A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 LEU A 309
PRO A 197
GLU A 357
ARG A 326
 None
 1.06A 2jn3A-1j0hA:
undetectable		 2jn3A-1j0hA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		4 PHE A 268
LEU A 253
LEU A 254
ARG A 279
 None
 1.01A 2jn3A-1k7hA:
undetectable		 2jn3A-1k7hA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		4 PHE A 315
LEU A 323
GLU A 306
ARG A 311
 None
 0.99A 2jn3A-1k9xA:
undetectable		 2jn3A-1k9xA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kej TERMINAL
DEOXYNUCLEOTIDYLTRAN
SFERASE SHORT
ISOFORM

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 PHE A 456
LEU A 460
LEU A 472
GLU A 504
 None
 1.04A 2jn3A-1kejA:
undetectable		 2jn3A-1kejA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 LEU A 297
LEU A  28
PRO A 286
ARG A 289
 None
None
HEM  A 430 (-4.5A)
HEM  A 430 (-3.0A)
 1.01A 2jn3A-1lgfA:
undetectable		 2jn3A-1lgfA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 PHE A  51
LEU A 164
LEU A 169
PRO A 361
 None
 1.03A 2jn3A-1mkyA:
undetectable		 2jn3A-1mkyA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd N15 ALPHA-BETA
T-CELL RECEPTOR

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B  21
PRO B  61
GLU B  83
ARG B  64
 None
 1.07A 2jn3A-1nfdB:
undetectable		 2jn3A-1nfdB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 PHE A  13
LEU A  29
GLU A  10
ARG A  55
 None
 1.06A 2jn3A-1nsaA:
undetectable		 2jn3A-1nsaA:
16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		4 PHE A  17
LEU A  21
GLU A 110
ARG A 121
 None
 1.04A 2jn3A-1o1uA:
18.0		 2jn3A-1o1uA:
41.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 LEU A 780
PRO A 785
GLU A 676
ARG A 353
 None
 1.03A 2jn3A-1ogyA:
undetectable		 2jn3A-1ogyA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 LEU A 109
PRO A   8
GLU A  99
ARG A  88
 None
 0.96A 2jn3A-1qjcA:
undetectable		 2jn3A-1qjcA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		4 PHE A 581
LEU A 583
LEU A 553
GLU A 697
 None
 1.08A 2jn3A-1qu2A:
undetectable		 2jn3A-1qu2A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 LEU D 168
LEU D  62
PRO C  55
GLU C 118
ARG D 154
 None
None
AGS  C 803 (-4.1A)
AGS  C 803 ( 4.9A)
AGS  C 803 (-4.6A)
 1.46A 2jn3A-1sxjD:
undetectable		 2jn3A-1sxjD:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B 266
LEU B 103
PRO B 366
ARG B 110
 None
None
None
SO4  B3105 (-2.9A)
 0.98A 2jn3A-1t3qB:
undetectable		 2jn3A-1t3qB:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		4 LEU A 167
LEU A 174
ARG A 111
GLU A  94
 None
 0.97A 2jn3A-1tqxA:
undetectable		 2jn3A-1tqxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o VON WILLEBRAND
FACTOR

(Mus musculus) 		PF00092
(VWA) 		4 PHE C 536
LEU C 621
GLU C 689
ARG C 686
 None
 0.84A 2jn3A-1u0oC:
undetectable		 2jn3A-1u0oC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 LEU A 376
ARG A 303
GLU A 241
ARG A 237
 None
 1.06A 2jn3A-1vefA:
undetectable		 2jn3A-1vefA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 PHE A 449
LEU A 387
LEU A 423
PRO A 381
 None
 0.92A 2jn3A-1wdtA:
undetectable		 2jn3A-1wdtA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 369
LEU A 208
PRO A 386
GLU A 410
 None
 1.04A 2jn3A-1wytA:
undetectable		 2jn3A-1wytA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		4 PHE A 126
LEU A 228
LEU A 207
ARG A 198
 None
 0.68A 2jn3A-1x7pA:
undetectable		 2jn3A-1x7pA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		4 LEU A 762
LEU A 763
ARG A 724
ARG A 755
 None
 1.02A 2jn3A-1xfuA:
undetectable		 2jn3A-1xfuA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 PHE A 679
LEU A 660
LEU A 666
ARG A 673
 None
 1.04A 2jn3A-1y1uA:
undetectable		 2jn3A-1y1uA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y97 THREE PRIME REPAIR
EXONUCLEASE 2

(Homo sapiens) 		no annotation 4 LEU A 197
LEU A 172
GLU A 207
ARG A 204
 None
 1.01A 2jn3A-1y97A:
undetectable		 2jn3A-1y97A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 492
LEU A 569
GLU A 462
ARG A 480
 None
 0.90A 2jn3A-1yr2A:
undetectable		 2jn3A-1yr2A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		4 PHE A1521
LEU A1402
GLU A1323
ARG A1522
 None
 1.02A 2jn3A-1yrzA:
undetectable		 2jn3A-1yrzA:
14.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		4 LEU A  21
LEU A  23
GLU A 109
ARG A 120
 None
 0.94A 2jn3A-1zryA:
12.4		 2jn3A-1zryA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		4 LEU A  23
PRO A  36
GLU A 109
ARG A 120
 None
 1.00A 2jn3A-1zryA:
12.4		 2jn3A-1zryA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a35 HYPOTHETICAL PROTEIN
PA4017

(Pseudomonas
aeruginosa) 		PF08732
(HIM1) 		4 PHE A  70
LEU A 110
GLU A  28
ARG A  24
 None
 1.00A 2jn3A-2a35A:
undetectable		 2jn3A-2a35A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		4 LEU A 234
PRO A 143
ARG A 140
GLU A 155
 None
 0.96A 2jn3A-2amxA:
undetectable		 2jn3A-2amxA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayx SENSOR KINASE
PROTEIN RCSC

(Escherichia
coli) 		PF00072
(Response_reg)
PF09456
(RcsC) 		4 LEU A 726
LEU A 722
PRO A 808
GLU A 802
 None
 1.05A 2jn3A-2ayxA:
undetectable		 2jn3A-2ayxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		4 LEU A  55
PRO A 292
ARG A 298
ARG A  95
 None
 0.93A 2jn3A-2bb6A:
undetectable		 2jn3A-2bb6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 PHE A  83
LEU A 109
LEU A 110
PRO A 173
 None
 0.71A 2jn3A-2bklA:
undetectable		 2jn3A-2bklA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		4 LEU A  23
LEU A 117
GLU A  70
ARG A  89
 None
 0.69A 2jn3A-2cbfA:
undetectable		 2jn3A-2cbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjs UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2) 		4 PHE A  49
LEU A  26
LEU A  60
GLU A  46
 None
None
None
EDO  A1156 (-3.8A)
 1.04A 2jn3A-2cjsA:
undetectable		 2jn3A-2cjsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjt UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2) 		4 PHE A  49
LEU A  26
LEU A  60
GLU A  46
 FMT  A1139 ( 4.3A)
None
None
None
 1.05A 2jn3A-2cjtA:
undetectable		 2jn3A-2cjtA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		4 LEU A  38
LEU A  42
GLU A  63
ARG A  67
 None
 1.08A 2jn3A-2cu2A:
undetectable		 2jn3A-2cu2A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqw DIHYDROPTEROATE
SYNTHASE

(Thermus
thermophilus) 		PF00809
(Pterin_bind) 		4 LEU A  17
LEU A  19
GLU A 283
ARG A  28
 None
 1.06A 2jn3A-2dqwA:
undetectable		 2jn3A-2dqwA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		4 LEU A 524
ARG A 305
GLU A 273
ARG A 270
 None
 1.06A 2jn3A-2et6A:
undetectable		 2jn3A-2et6A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli) 		PF03602
(Cons_hypoth95) 		4 LEU A 114
PRO A 129
ARG A 131
GLU A  82
 None
 1.05A 2jn3A-2fpoA:
undetectable		 2jn3A-2fpoA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		4 LEU A  23
PRO A  36
GLU A 109
ARG A 120
 None
 0.80A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		4 PHE A  17
LEU A  23
PRO A  36
GLU A 109
 None
 0.79A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		4 LEU A 337
PRO A 209
GLU A 236
ARG A  64
 None
 1.07A 2jn3A-2greA:
undetectable		 2jn3A-2greA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 PHE A 224
LEU A 271
LEU A  97
ARG A 222
 None
None
None
SAM  A 801 (-3.3A)
 1.08A 2jn3A-2h21A:
undetectable		 2jn3A-2h21A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 PHE A 607
LEU A 611
LEU A 612
PRO A 116
 None
None
None
FAD  A 700 (-4.2A)
 0.96A 2jn3A-2i0kA:
undetectable		 2jn3A-2i0kA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PHE A 292
LEU A 301
LEU A 325
GLU A 288
 None
 0.89A 2jn3A-2id5A:
undetectable		 2jn3A-2id5A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 PHE A 187
LEU A 190
LEU A 194
GLU A 147
 None
 0.95A 2jn3A-2iyaA:
undetectable		 2jn3A-2iyaA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9r HOMEOBOX PROTEIN
NKX-3.1

(Homo sapiens) 		PF00046
(Homeobox) 		4 PHE A  52
LEU A  37
LEU A  41
ARG A  55
 None
 1.01A 2jn3A-2l9rA:
undetectable		 2jn3A-2l9rA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE

(Streptomyces
virginiae) 		PF00550
(PP-binding) 		4 PHE A6776
LEU A6766
ARG A6756
GLU A6741
 None
 1.02A 2jn3A-2mf4A:
undetectable		 2jn3A-2mf4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 LEU A 770
PRO A 775
GLU A 666
ARG A 343
 None
 1.03A 2jn3A-2nyaA:
undetectable		 2jn3A-2nyaA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		5 LEU A 376
LEU A 377
ARG A 647
GLU A 630
ARG A 626
 None
 1.43A 2jn3A-2o36A:
undetectable		 2jn3A-2o36A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o62 HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		PF12204
(DUF3598) 		4 LEU A 137
LEU A 213
GLU A 266
ARG A 247
 None
 1.06A 2jn3A-2o62A:
6.2		 2jn3A-2o62A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		4 PHE A 175
LEU A 184
LEU A 208
PRO A 219
 None
 1.07A 2jn3A-2o6qA:
undetectable		 2jn3A-2o6qA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 PHE A 505
LEU A 443
ARG A 554
ARG A 502
 None
 0.91A 2jn3A-2okxA:
undetectable		 2jn3A-2okxA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A1043
ARG A1089
GLU A1063
ARG A1065
 None
None
None
B3P  A 301 (-4.3A)
 1.07A 2jn3A-2ooqA:
undetectable		 2jn3A-2ooqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 LEU A 163
ARG A 225
GLU A 102
ARG A 109
 None
 0.79A 2jn3A-2optA:
undetectable		 2jn3A-2optA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		4 PHE A1006
LEU A1010
LEU A1011
GLU A1060
 None
 1.00A 2jn3A-2p3vA:
2.3		 2jn3A-2p3vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 PHE B 572
LEU A 357
LEU B 577
ARG A 287
 None
None
None
SO4  A 901 (-2.9A)
 0.97A 2jn3A-2pjrB:
undetectable		 2jn3A-2pjrB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 PHE A 188
LEU A 183
LEU A 182
PRO A  72
 None
 0.97A 2jn3A-2plaA:
undetectable		 2jn3A-2plaA:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 PHE A  17
LEU A  23
PRO A  36
GLU A 109
ARG A 120
 None
CHD  A 130 ( 4.6A)
None
None
CHD  A 130 (-3.4A)
 0.72A 2jn3A-2qo4A:
21.0		 2jn3A-2qo4A:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsy TYROSINE-PROTEIN
KINASE CSK

(Rattus
norvegicus) 		PF00017
(SH2) 		4 PHE A  83
LEU A 149
LEU A 152
ARG A 107
 None
None
None
PTR  B 314 ( 4.4A)
 0.99A 2jn3A-2rsyA:
undetectable		 2jn3A-2rsyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		4 LEU A 388
LEU A 456
PRO A  35
ARG A 507
 None
None
PO4  A1541 (-4.4A)
None
 1.00A 2jn3A-2vl7A:
undetectable		 2jn3A-2vl7A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 405
LEU A 571
PRO A 435
GLU A 522
 None
 0.87A 2jn3A-2vwkA:
undetectable		 2jn3A-2vwkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 117
LEU A 253
GLU A 114
ARG A 116
 None
 0.96A 2jn3A-2w2jA:
1.2		 2jn3A-2w2jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 LEU A  26
LEU A  23
PRO A 105
ARG A 113
 None
 0.91A 2jn3A-2x3kA:
undetectable		 2jn3A-2x3kA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 LEU A 374
LEU A 365
GLU A 348
ARG A 432
 None
 0.87A 2jn3A-2y4oA:
undetectable		 2jn3A-2y4oA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykq LINE-1 ORF1P

(Homo sapiens) 		PF02994
(Transposase_22)
PF17489
(Tnp_22_trimer)
PF17490
(Tnp_22_dsRBD) 		4 LEU A 249
PRO A 214
GLU A 169
ARG A 202
 None
 1.03A 2jn3A-2ykqA:
undetectable		 2jn3A-2ykqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PHE A 171
LEU A 180
LEU A 208
GLU A 142
 None
 0.95A 2jn3A-2z65A:
undetectable		 2jn3A-2z65A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF08839
(CDT1) 		4 LEU C 298
LEU C 303
GLU C 225
ARG C 223
 None
 1.06A 2jn3A-2zxxC:
undetectable		 2jn3A-2zxxC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 406
LEU A 572
PRO A 436
GLU A 523
 None
 1.06A 2jn3A-3a2fA:
undetectable		 2jn3A-3a2fA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I

(Legionella
pneumophila) 		PF01150
(GDA1_CD39) 		4 PHE A 309
LEU A 321
LEU A 316
PRO A 378
 None
 1.06A 2jn3A-3aarA:
undetectable		 2jn3A-3aarA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		4 PHE A 466
LEU A 437
ARG A 449
GLU A 359
 None
None
None
CA  A 488 (-3.4A)
 1.06A 2jn3A-3c7oA:
undetectable		 2jn3A-3c7oA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ced METHIONINE IMPORT
ATP-BINDING PROTEIN
METN 2

(Staphylococcus
aureus) 		PF09383
(NIL) 		4 PHE A 270
LEU A 309
LEU A 311
ARG A 331
 None
 0.99A 2jn3A-3cedA:
undetectable		 2jn3A-3cedA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF01636
(APH) 		4 PHE A 189
LEU A 226
LEU A 227
ARG A 258
 None
 0.96A 2jn3A-3csvA:
undetectable		 2jn3A-3csvA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		5 PHE A 313
PRO A 319
ARG A 324
GLU A 274
ARG A 280
 None
 1.49A 2jn3A-3dhuA:
2.2		 2jn3A-3dhuA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		4 PHE A 312
LEU A 320
GLU A 303
ARG A 308
 None
 0.98A 2jn3A-3dwcA:
undetectable		 2jn3A-3dwcA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ein GLUTATHIONE
S-TRANSFERASE 1-1

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 PHE A 135
LEU A 138
LEU A 142
GLU A 168
 None
 0.97A 2jn3A-3einA:
undetectable		 2jn3A-3einA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoj BACTERIOCHLOROPHYLL
A PROTEIN

(Prosthecochloris
aestuarii) 		PF02327
(BChl_A) 		4 LEU A 292
ARG A 125
GLU A 361
ARG A 286
 EDO  A 389 ( 4.4A)
None
None
None
 1.08A 2jn3A-3eojA:
undetectable		 2jn3A-3eojA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewn THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF01965
(DJ-1_PfpI) 		4 PHE A 211
LEU A 160
GLU A 218
ARG A 195
 None
 1.02A 2jn3A-3ewnA:
undetectable		 2jn3A-3ewnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 PHE A 215
LEU A 217
LEU A 129
ARG A  73
 None
 0.83A 2jn3A-3f41A:
undetectable		 2jn3A-3f41A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbf PHPD

(Streptomyces
viridochromogenes) 		no annotation 4 LEU A 367
LEU A 380
PRO A 110
GLU A 355
 None
 1.03A 2jn3A-3gbfA:
undetectable		 2jn3A-3gbfA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 374
LEU A 369
GLU A 270
ARG A 310
 None
 1.05A 2jn3A-3hhdA:
undetectable		 2jn3A-3hhdA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 PHE A 450
LEU A 454
LEU A 424
ARG A 443
 None
 1.03A 2jn3A-3hhdA:
undetectable		 2jn3A-3hhdA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hk0 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		4 LEU A 227
LEU A 223
GLU A 167
ARG A 337
 None
None
None
SCN  A  15 (-3.8A)
 0.98A 2jn3A-3hk0A:
undetectable		 2jn3A-3hk0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htv D-ALLOSE KINASE

(Escherichia
coli) 		PF00480
(ROK) 		4 PHE A  20
LEU A  22
LEU A  30
GLU A  51
 None
 1.02A 2jn3A-3htvA:
undetectable		 2jn3A-3htvA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 PHE A 678
LEU A 627
LEU A 629
GLU A 645
 None
 1.01A 2jn3A-3hvdA:
undetectable		 2jn3A-3hvdA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knw PUTATIVE
TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)

(Acinetobacter
sp. ADP1) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		4 PHE A  58
LEU A  62
LEU A  63
GLU A  36
 None
 0.97A 2jn3A-3knwA:
undetectable		 2jn3A-3knwA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		4 LEU A  80
LEU A  77
GLU A  98
ARG A  49
 None
 1.03A 2jn3A-3mq2A:
undetectable		 2jn3A-3mq2A:
17.22