SIMILAR PATTERNS OF AMINO ACIDS FOR 2JN3_A_JN3A130_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 LEU A  70
LEU A  77
ALA A  84
ILE A  85
LEU A  59
 None
 1.15A 2jn3A-1amyA:
undetectable		 2jn3A-1amyA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		5 LEU A 264
THR A 160
MET A  68
ILE A 127
LEU A 211
 None
 1.10A 2jn3A-1bsgA:
0.0		 2jn3A-1bsgA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 LEU A 260
ALA A 305
ASP A 263
ILE A 333
LEU A 330
 None
 1.14A 2jn3A-1c3rA:
0.0		 2jn3A-1c3rA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		5 LEU A 151
ILE A  81
HIS A 263
ILE A 237
LEU A 147
 None
 1.01A 2jn3A-1c4xA:
undetectable		 2jn3A-1c4xA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF TUBE

(Drosophila
melanogaster) 		PF14786
(Death_2) 		5 LEU B 132
LEU B 141
ALA B 144
ILE B  47
LEU B  33
 None
 1.16A 2jn3A-1d2zB:
0.0		 2jn3A-1d2zB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		5 ALA A 171
ILE A 116
ASP A 106
ILE A 189
LEU A 193
 None
 1.01A 2jn3A-1eb3A:
undetectable		 2jn3A-1eb3A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.16A 2jn3A-1es6A:
0.6		 2jn3A-1es6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		5 TYR A 116
LEU A 103
ILE A  37
ILE A 154
LEU A   5
 None
 1.16A 2jn3A-1fy2A:
undetectable		 2jn3A-1fy2A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 ENDOBREVIN
SYNTAXIN 7
SYNTAXIN 8

(Mus musculus;
Rattus
norvegicus) 		PF00957
(Synaptobrevin)
PF05739
(SNARE)
no annotation 		5 LEU A  15
ILE D 161
ASP D 156
ILE B 175
LEU B 178
 None
 1.08A 2jn3A-1gl2A:
undetectable		 2jn3A-1gl2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 627
ILE A 592
THR A 614
ASP A 588
ILE A 507
 None
 0.98A 2jn3A-1ji6A:
0.0		 2jn3A-1ji6A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		5 LEU A 241
ILE A  68
THR A  65
GLN A  63
HIS A 250
 None
 1.09A 2jn3A-1ktnA:
undetectable		 2jn3A-1ktnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhc MHC CLASS I ANTIGEN
H2-M3

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 TYR A 114
LEU A  95
ALA A 116
ILE A 124
THR A 143
 None
 1.04A 2jn3A-1mhcA:
undetectable		 2jn3A-1mhcA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU X 486
ALA X 200
ILE X 504
THR X 503
LEU X 537
 None
 1.10A 2jn3A-1mw9X:
undetectable		 2jn3A-1mw9X:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 LEU A 137
LEU A 130
ILE A 246
HIS A  58
LEU A  28
 None
 1.11A 2jn3A-1nkvA:
undetectable		 2jn3A-1nkvA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A1108
ALA A1117
ASP A1105
ILE A1055
LEU A1101
 None
None
FMN  A2508 (-3.0A)
None
None
 1.09A 2jn3A-1ofeA:
2.0		 2jn3A-1ofeA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3r DISABLED HOMOLOG 2

(Mus musculus) 		PF00640
(PID) 		5 LEU A 158
ALA A  52
ILE A  93
ILE A 124
LEU A 162
 None
 1.17A 2jn3A-1p3rA:
1.4		 2jn3A-1p3rA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		6 TYR A  14
ALA A  31
THR A  53
HIS A  98
ILE A 111
LEU A 118
 None
 0.87A 2jn3A-1p6pA:
18.3		 2jn3A-1p6pA:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		6 TYR A  14
LEU A  18
ALA A  31
THR A  53
ILE A 111
LEU A 118
 None
 0.99A 2jn3A-1p6pA:
18.3		 2jn3A-1p6pA:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		6 TYR A  14
LEU A  18
THR A  53
GLN A  56
ILE A 111
LEU A 118
 None
 0.97A 2jn3A-1p6pA:
18.3		 2jn3A-1p6pA:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		6 TYR A  14
THR A  53
GLN A  56
HIS A  98
ILE A 111
LEU A 118
 None
 0.89A 2jn3A-1p6pA:
18.3		 2jn3A-1p6pA:
66.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 639
ALA A 695
ILE A 694
ILE A 556
LEU A 453
 None
 1.13A 2jn3A-1r8wA:
undetectable		 2jn3A-1r8wA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		5 TYR A 144
ILE A 235
ASP A 294
ILE A 178
LEU A 176
 None
 1.17A 2jn3A-1ry6A:
undetectable		 2jn3A-1ry6A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167

(Pseudomonas
aeruginosa) 		PF08787
(Alginate_lyase2) 		5 LEU A 218
THR A  22
GLN A  26
HIS A 222
LEU A  83
 None
 1.14A 2jn3A-1vavA:
undetectable		 2jn3A-1vavA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans) 		PF01960
(ArgJ) 		5 ALA B 368
ILE B 352
THR B 354
ASP B 323
ILE B 289
 None
 1.16A 2jn3A-1vraB:
undetectable		 2jn3A-1vraB:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		5 LEU A  88
ALA A  91
ILE A  29
THR A  52
ILE A   3
 None
 1.14A 2jn3A-1ye8A:
undetectable		 2jn3A-1ye8A:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		5 TYR A  14
LEU A  23
ALA A  31
ASP A  74
LEU A 118
 None
 0.93A 2jn3A-1zryA:
12.4		 2jn3A-1zryA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		6 TYR A  14
LEU A  23
ALA A  31
ILE A  34
THR A  53
LEU A 118
 None
 0.95A 2jn3A-1zryA:
12.4		 2jn3A-1zryA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A 434
ILE A 463
THR A 465
ASP A 475
LEU A 535
 None
 1.14A 2jn3A-2a8bA:
undetectable		 2jn3A-2a8bA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5

(Homo sapiens) 		PF00102
(Y_phosphatase) 		6 LEU A 317
ILE A 346
THR A 348
ASP A 358
ILE A 400
LEU A 418
 None
 1.10A 2jn3A-2bv5A:
undetectable		 2jn3A-2bv5A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A 930
ILE A 957
THR A 959
ASP A 969
LEU A1030
 None
 1.18A 2jn3A-2c7sA:
undetectable		 2jn3A-2c7sA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbi PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF01047
(MarR) 		5 LEU A  69
ALA A  55
GLN A  53
MET A  49
LEU A  72
 None
 1.15A 2jn3A-2fbiA:
undetectable		 2jn3A-2fbiA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		7 TYR A  14
LEU A  18
ALA A  31
ILE A  34
THR A  53
GLN A  56
HIS A  98
 None
None
OLA  A 130 (-3.3A)
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.4A)
OLA  A 130 ( 4.8A)
 1.12A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		7 TYR A  14
LEU A  18
ALA A  31
ILE A  34
THR A  53
HIS A  98
LEU A 118
 None
None
OLA  A 130 (-3.3A)
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.8A)
None
 0.82A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED

(Streptococcus
suis) 		PF01243
(Putative_PNPOx) 		5 LEU A  56
ALA A  83
ILE A 118
HIS A 103
ILE A 104
 None
 1.08A 2jn3A-2hhzA:
2.6		 2jn3A-2hhzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED

(Streptococcus
suis) 		PF01243
(Putative_PNPOx) 		5 LEU A  56
ALA A  83
ILE A 118
HIS A 103
LEU A  91
 None
 0.94A 2jn3A-2hhzA:
2.6		 2jn3A-2hhzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5v NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 10

(Homo sapiens) 		PF02758
(PYRIN) 		5 LEU A  15
LEU A  63
ALA A  72
THR A  38
LEU A  92
 None
 1.18A 2jn3A-2m5vA:
undetectable		 2jn3A-2m5vA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv5 PTPRD, PHOSPHATASE

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		5 LEU A1270
ILE A1297
THR A1299
ASP A1309
LEU A1371
 None
 1.14A 2jn3A-2nv5A:
0.3		 2jn3A-2nv5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU D  93
LEU D  40
ALA D  59
HIS D 112
ILE D 111
 None
 1.12A 2jn3A-2qe7D:
undetectable		 2jn3A-2qe7D:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A 789
ILE A 817
THR A 819
ASP A 829
LEU A 892
 None
 1.17A 2jn3A-2qepA:
undetectable		 2jn3A-2qepA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 LEU A 420
ALA A 252
ILE A 255
ILE A 403
LEU A   6
 None
 1.19A 2jn3A-2qfqA:
undetectable		 2jn3A-2qfqA:
15.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		6 TYR A  14
LEU A  18
ALA A  31
THR A  53
ASP A  74
HIS A  98
 None
CHD  A 130 ( 4.7A)
CHD  A 130 ( 3.8A)
CHD  A 130 ( 4.1A)
GOL  A 145 ( 2.8A)
IPA  A 140 (-3.7A)
 0.87A 2jn3A-2qo4A:
21.0		 2jn3A-2qo4A:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		5 LEU A 351
ALA A 211
ASP A 257
ILE A 324
LEU A 297
 None
 1.16A 2jn3A-2rfzA:
undetectable		 2jn3A-2rfzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzp PROTEIN KINASE C
GAMMA TYPE

(Homo sapiens) 		PF00168
(C2) 		5 LEU A 240
LEU A 163
THR A 212
ILE A 201
LEU A 200
 None
 1.07A 2jn3A-2uzpA:
undetectable		 2jn3A-2uzpA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		5 LEU A 491
LEU A 483
ALA A 481
ILE A 414
LEU A 493
 None
 1.07A 2jn3A-2vrkA:
undetectable		 2jn3A-2vrkA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypr PROTEIN FEV

(Homo sapiens) 		PF00178
(Ets) 		5 LEU A 101
ALA A 104
GLN A  48
ILE A  66
LEU A  77
 None
 1.07A 2jn3A-2yprA:
undetectable		 2jn3A-2yprA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy8 UPF0106 PROTEIN
PH0461

(Pyrococcus
horikoshii) 		PF01994
(Trm56) 		5 LEU A 138
ALA A  30
ILE A   2
ILE A 127
LEU A  80
 None
None
None
MTA  A 400 (-4.3A)
MTA  A 400 (-4.2A)
 1.13A 2jn3A-2yy8A:
undetectable		 2jn3A-2yy8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 406
ALA A 510
ILE A 388
HIS A 424
ILE A 461
 None
CSO  A 509 (-3.8A)
GOL  A 902 (-3.5A)
None
None
 1.02A 2jn3A-2z2wA:
undetectable		 2jn3A-2z2wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqe MUTS2 PROTEIN

(Thermus
thermophilus) 		PF01713
(Smr) 		5 LEU A  24
ALA A  27
HIS A  39
ILE A  50
LEU A  54
 None
 1.17A 2jn3A-2zqeA:
undetectable		 2jn3A-2zqeA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zym SOLUTE-BINDING
PROTEIN

(Thermoactinomyces
vulgaris) 		PF13416
(SBP_bac_8) 		5 LEU A  77
ILE A  49
THR A  47
ILE A  97
LEU A 286
 None
 1.16A 2jn3A-2zymA:
undetectable		 2jn3A-2zymA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4r NFATC2-INTERACTING
PROTEIN

(Mus musculus) 		PF11976
(Rad60-SLD) 		6 LEU A 341
LEU A  -2
ALA A 398
ASP A 361
ILE A 356
LEU A 343
 None
 1.18A 2jn3A-3a4rA:
undetectable		 2jn3A-3a4rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU B 231
ALA B 170
ILE B 164
HIS B  12
LEU B 196
 None
 1.14A 2jn3A-3al0B:
undetectable		 2jn3A-3al0B:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clj PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF04818
(CTD_bind) 		5 LEU A 136
ILE A  72
THR A  33
ASP A  78
ILE A 130
 None
 0.96A 2jn3A-3cljA:
undetectable		 2jn3A-3cljA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6y ESTERASE APC40077

(Oleispira
antarctica) 		PF00756
(Esterase) 		5 LEU A  55
ILE A 174
GLN A 230
ASP A  98
LEU A 191
 CL  A 280 (-3.6A)
None
None
None
None
 1.08A 2jn3A-3i6yA:
undetectable		 2jn3A-3i6yA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il0 XAA-PRO
AMINOPEPTIDASE
AMINOPEPTIDASE P

(Streptococcus
thermophilus) 		PF01321
(Creatinase_N) 		5 LEU A  88
ALA A  19
ASP A  86
ILE A  70
LEU A  51
 None
 0.83A 2jn3A-3il0A:
undetectable		 2jn3A-3il0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 608
ALA B 568
ILE B 571
ASP B 605
LEU B 613
 None
 1.12A 2jn3A-3kx2B:
undetectable		 2jn3A-3kx2B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls2 S-FORMYLGLUTATHIONE
HYDROLASE

(Pseudoalteromonas
haloplanktis) 		PF00756
(Esterase) 		5 LEU A  54
ILE A 173
GLN A 231
ASP A  97
LEU A 190
 None
 1.07A 2jn3A-3ls2A:
undetectable		 2jn3A-3ls2A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvp TETR/ACRR
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
mutans) 		PF00440
(TetR_N) 		5 ALA A  35
ILE A  52
THR A  49
ILE A 136
LEU A 132
 None
 1.18A 2jn3A-3mvpA:
undetectable		 2jn3A-3mvpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 ALA D 317
GLN D 343
HIS D 170
ILE D 166
LEU D 162
 None
 1.08A 2jn3A-3oaaD:
undetectable		 2jn3A-3oaaD:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rdj PROTEIN KINASE C
ALPHA TYPE

(Rattus
norvegicus) 		PF00168
(C2) 		5 LEU A 240
LEU A 164
THR A 212
ILE A 201
LEU A 200
 None
 1.09A 2jn3A-3rdjA:
undetectable		 2jn3A-3rdjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		5 LEU A 156
ALA A 118
ASP A 111
ILE A 195
LEU A 199
 None
 1.19A 2jn3A-3ta6A:
undetectable		 2jn3A-3ta6A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcq MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.13A 2jn3A-3tcqA:
undetectable		 2jn3A-3tcqA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 LEU A 348
ALA A 352
ILE A 217
HIS A 314
ILE A 313
 None
 1.18A 2jn3A-3vthA:
undetectable		 2jn3A-3vthA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		5 LEU A  52
ILE A 171
GLN A 227
ASP A  95
LEU A 188
 None
 1.10A 2jn3A-4b6gA:
undetectable		 2jn3A-4b6gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A1435
ILE A1462
THR A1464
ASP A1474
LEU A1536
 None
 1.13A 2jn3A-4bpcA:
undetectable		 2jn3A-4bpcA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		5 LEU A 188
ILE A 127
HIS A 280
ILE A 193
LEU A 192
 None
 1.09A 2jn3A-4ci0A:
undetectable		 2jn3A-4ci0A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		5 LEU A 235
LEU A 398
ILE A 247
THR A 263
ILE A 218
 None
SO4  A 605 (-4.6A)
None
None
None
 1.10A 2jn3A-4fwwA:
undetectable		 2jn3A-4fwwA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gft MYOSIN A TAIL DOMAIN
INTERACTING PROTEIN

(Plasmodium
falciparum) 		PF13405
(EF-hand_6) 		5 LEU A 203
ALA A 183
ASP A 201
ILE A 145
LEU A 144
 None
 1.00A 2jn3A-4gftA:
undetectable		 2jn3A-4gftA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		5 LEU A 383
ALA A 415
ILE A 431
HIS A 392
ILE A 391
 None
 1.11A 2jn3A-4ke4A:
undetectable		 2jn3A-4ke4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld8 MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.15A 2jn3A-4ld8A:
undetectable		 2jn3A-4ld8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		5 LEU D  93
ALA D  92
ILE D  85
ILE D 165
LEU D 166
 None
 0.94A 2jn3A-4mwaD:
undetectable		 2jn3A-4mwaD:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		5 LEU A 269
ALA A 311
ILE A 314
ASP A 268
LEU A 496
 None
 1.16A 2jn3A-4mzdA:
undetectable		 2jn3A-4mzdA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on1 PUTATIVE
METALLOPROTEASE II

(Bacteroides
fragilis) 		PF00413
(Peptidase_M10)
PF16376
(fragilysinNterm) 		5 LEU A  48
LEU A  40
ILE A  62
THR A  73
ILE A 104
 None
 1.13A 2jn3A-4on1A:
undetectable		 2jn3A-4on1A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on1 PUTATIVE
METALLOPROTEASE II

(Bacteroides
fragilis) 		PF00413
(Peptidase_M10)
PF16376
(fragilysinNterm) 		5 LEU A  48
LEU A  40
ILE A  62
THR A  73
LEU A 105
 None
 1.14A 2jn3A-4on1A:
undetectable		 2jn3A-4on1A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqa POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg)
PF05406
(WGR) 		5 LEU C 698
ILE C 643
THR C 556
HIS C 742
LEU C 768
 None
 1.07A 2jn3A-4oqaC:
0.9		 2jn3A-4oqaC:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 547
LEU A 649
ALA A 594
ILE A 633
LEU A 630
 None
 1.13A 2jn3A-4oqjA:
undetectable		 2jn3A-4oqjA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5x CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR1

(Homo sapiens) 		no annotation 5 TYR A 218
LEU A 277
ALA A 205
ASP A 276
LEU A 266
 None
 1.13A 2jn3A-4p5xA:
undetectable		 2jn3A-4p5xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		no annotation 5 LEU B 235
LEU B 398
ILE B 247
THR B 263
ILE B 218
 None
 1.14A 2jn3A-4qt8B:
undetectable		 2jn3A-4qt8B:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Homo sapiens) 		PF01704
(UDPGP) 		5 LEU A 108
ILE A 146
THR A 142
ILE A 263
LEU A 264
 None
 1.13A 2jn3A-4r7pA:
undetectable		 2jn3A-4r7pA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU A1748
ALA A1751
ILE A1349
ILE A1300
LEU A1304
 None
 1.19A 2jn3A-4r7yA:
undetectable		 2jn3A-4r7yA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Weissella
paramesenteroides) 		PF13377
(Peripla_BP_3) 		5 LEU A  82
ALA A 301
ILE A 143
ILE A  95
LEU A  93
 None
 1.14A 2jn3A-4rk6A:
undetectable		 2jn3A-4rk6A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		5 ILE B   8
THR B  38
ASP B 111
ILE B  25
LEU B  26
 None
None
MG  B 301 ( 4.1A)
None
None
 1.12A 2jn3A-4s1iB:
undetectable		 2jn3A-4s1iB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		5 LEU A 401
THR A 326
MET A 376
ASP A 378
LEU A  89
 None
 1.02A 2jn3A-4upiA:
undetectable		 2jn3A-4upiA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		5 LEU A  60
ALA A  69
ILE A  73
THR A  47
ILE A 466
 None
 1.17A 2jn3A-4y23A:
undetectable		 2jn3A-4y23A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 LEU A 231
ILE A 212
THR A 210
ILE A  54
LEU A  53
 None
 1.00A 2jn3A-5a22A:
undetectable		 2jn3A-5a22A:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 LEU A 119
LEU A 217
ALA A 222
ILE A  29
LEU A  30
 None
 1.08A 2jn3A-5aeeA:
2.1		 2jn3A-5aeeA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus) 		PF00946
(Mononeg_RNA_pol) 		5 LEU A 231
ILE A 212
THR A 210
ILE A  54
LEU A  53
 None
 1.18A 2jn3A-5chsA:
undetectable		 2jn3A-5chsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2j 4-OXALOCROTONATE
DECARBOXYLASE NAHK

(Pseudomonas
putida) 		no annotation 5 LEU A 182
LEU A 256
ILE A 138
ILE A 131
LEU A 209
 None
 1.19A 2jn3A-5d2jA:
undetectable		 2jn3A-5d2jA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep0 PUTATIVE REPRESSOR
PROTEIN LUXO

(Photobacterium
angustum) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 LEU A  55
LEU A  66
ALA A  93
ILE A  94
GLN A  99
 None
 1.06A 2jn3A-5ep0A:
undetectable		 2jn3A-5ep0A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		5 LEU A 462
ALA A 436
ILE A 438
ILE A 515
LEU A 520
 None
 1.16A 2jn3A-5esoA:
undetectable		 2jn3A-5esoA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		5 LEU A  52
ALA A  16
THR A 407
ILE A 199
LEU A 209
 None
 1.06A 2jn3A-5htpA:
undetectable		 2jn3A-5htpA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2c GATS-LIKE PROTEIN 3

(Homo sapiens) 		PF13840
(ACT_7) 		5 LEU A 113
ALA A  72
GLN A  70
HIS A 175
ILE A 280
 ARG  A 401 ( 4.9A)
None
None
None
ARG  A 401 (-3.9A)
 1.01A 2jn3A-5i2cA:
undetectable		 2jn3A-5i2cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A 264
LEU A 232
THR A 213
GLN A 214
ILE A 252
 None
 1.16A 2jn3A-5k8rA:
undetectable		 2jn3A-5k8rA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 LEU A 361
ILE A 369
THR A 492
ILE A 404
LEU A 350
 None
 1.03A 2jn3A-5lq3A:
undetectable		 2jn3A-5lq3A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noh TRANSCRIPTION
ELONGATION FACTOR
M2-1

(Human
orthopneumovirus) 		no annotation 5 LEU A  31
LEU A  77
ILE A  89
ILE A  39
LEU A  34
 None
 1.16A 2jn3A-5nohA:
undetectable		 2jn3A-5nohA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		5 LEU 5 113
ILE 5 314
THR 5 126
ILE 5 262
LEU 5 265
 None
 1.14A 2jn3A-5ool5:
undetectable		 2jn3A-5ool5:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		5 TYR A 297
LEU A  69
ALA A  73
ILE A 237
LEU A 236
 None
 1.16A 2jn3A-5uiwA:
undetectable		 2jn3A-5uiwA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Chaetomium
thermophilum) 		no annotation 5 LEU A   6
LEU A  51
ILE A  20
THR A 139
LEU A 159
 None
 1.16A 2jn3A-5w8mA:
undetectable		 2jn3A-5w8mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5) 		no annotation 5 LEU A 233
LEU A 171
ALA A 174
ILE A 219
MET A  76
 None
 1.11A 2jn3A-5wknA:
undetectable		 2jn3A-5wknA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 LEU A 421
ALA A 253
ILE A 256
THR A 322
ILE A 404
 None
 1.11A 2jn3A-5xwbA:
undetectable		 2jn3A-5xwbA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 5 LEU A1545
ALA A1311
HIS A1655
ILE A1656
LEU A1659
 None
 1.08A 2jn3A-6b3rA:
undetectable		 2jn3A-6b3rA:
16.67