SIMILAR PATTERNS OF AMINO ACIDS FOR 2JN3_A_JN3A130

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 LEU A  70
LEU A  77
ALA A  84
ILE A  85
LEU A  59
 None
 1.15A 2jn3A-1amyA:
undetectable		 2jn3A-1amyA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		5 LEU A 264
THR A 160
MET A  68
ILE A 127
LEU A 211
 None
 1.10A 2jn3A-1bsgA:
0.0		 2jn3A-1bsgA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 LEU A 260
ALA A 305
ASP A 263
ILE A 333
LEU A 330
 None
 1.14A 2jn3A-1c3rA:
0.0		 2jn3A-1c3rA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		5 LEU A 151
ILE A  81
HIS A 263
ILE A 237
LEU A 147
 None
 1.01A 2jn3A-1c4xA:
undetectable		 2jn3A-1c4xA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF TUBE

(Drosophila
melanogaster) 		PF14786
(Death_2) 		5 LEU B 132
LEU B 141
ALA B 144
ILE B  47
LEU B  33
 None
 1.16A 2jn3A-1d2zB:
0.0		 2jn3A-1d2zB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		5 ALA A 171
ILE A 116
ASP A 106
ILE A 189
LEU A 193
 None
 1.01A 2jn3A-1eb3A:
undetectable		 2jn3A-1eb3A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.16A 2jn3A-1es6A:
0.6		 2jn3A-1es6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		5 TYR A 116
LEU A 103
ILE A  37
ILE A 154
LEU A   5
 None
 1.16A 2jn3A-1fy2A:
undetectable		 2jn3A-1fy2A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 ENDOBREVIN
SYNTAXIN 7
SYNTAXIN 8

(Mus musculus;
Rattus
norvegicus) 		PF00957
(Synaptobrevin)
PF05739
(SNARE)
no annotation 		5 LEU A  15
ILE D 161
ASP D 156
ILE B 175
LEU B 178
 None
 1.08A 2jn3A-1gl2A:
undetectable		 2jn3A-1gl2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 627
ILE A 592
THR A 614
ASP A 588
ILE A 507
 None
 0.98A 2jn3A-1ji6A:
0.0		 2jn3A-1ji6A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		5 LEU A 241
ILE A  68
THR A  65
GLN A  63
HIS A 250
 None
 1.09A 2jn3A-1ktnA:
undetectable		 2jn3A-1ktnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhc MHC CLASS I ANTIGEN
H2-M3

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 TYR A 114
LEU A  95
ALA A 116
ILE A 124
THR A 143
 None
 1.04A 2jn3A-1mhcA:
undetectable		 2jn3A-1mhcA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU X 486
ALA X 200
ILE X 504
THR X 503
LEU X 537
 None
 1.10A 2jn3A-1mw9X:
undetectable		 2jn3A-1mw9X:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 LEU A 137
LEU A 130
ILE A 246
HIS A  58
LEU A  28
 None
 1.11A 2jn3A-1nkvA:
undetectable		 2jn3A-1nkvA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A1108
ALA A1117
ASP A1105
ILE A1055
LEU A1101
 None
None
FMN  A2508 (-3.0A)
None
None
 1.09A 2jn3A-1ofeA:
2.0		 2jn3A-1ofeA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3r DISABLED HOMOLOG 2

(Mus musculus) 		PF00640
(PID) 		5 LEU A 158
ALA A  52
ILE A  93
ILE A 124
LEU A 162
 None
 1.17A 2jn3A-1p3rA:
1.4		 2jn3A-1p3rA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		6 TYR A  14
ALA A  31
THR A  53
HIS A  98
ILE A 111
LEU A 118
 None
 0.87A 2jn3A-1p6pA:
18.3		 2jn3A-1p6pA:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		6 TYR A  14
LEU A  18
ALA A  31
THR A  53
ILE A 111
LEU A 118
 None
 0.99A 2jn3A-1p6pA:
18.3		 2jn3A-1p6pA:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		6 TYR A  14
LEU A  18
THR A  53
GLN A  56
ILE A 111
LEU A 118
 None
 0.97A 2jn3A-1p6pA:
18.3		 2jn3A-1p6pA:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		6 TYR A  14
THR A  53
GLN A  56
HIS A  98
ILE A 111
LEU A 118
 None
 0.89A 2jn3A-1p6pA:
18.3		 2jn3A-1p6pA:
66.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 639
ALA A 695
ILE A 694
ILE A 556
LEU A 453
 None
 1.13A 2jn3A-1r8wA:
undetectable		 2jn3A-1r8wA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		5 TYR A 144
ILE A 235
ASP A 294
ILE A 178
LEU A 176
 None
 1.17A 2jn3A-1ry6A:
undetectable		 2jn3A-1ry6A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167

(Pseudomonas
aeruginosa) 		PF08787
(Alginate_lyase2) 		5 LEU A 218
THR A  22
GLN A  26
HIS A 222
LEU A  83
 None
 1.14A 2jn3A-1vavA:
undetectable		 2jn3A-1vavA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans) 		PF01960
(ArgJ) 		5 ALA B 368
ILE B 352
THR B 354
ASP B 323
ILE B 289
 None
 1.16A 2jn3A-1vraB:
undetectable		 2jn3A-1vraB:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		5 LEU A  88
ALA A  91
ILE A  29
THR A  52
ILE A   3
 None
 1.14A 2jn3A-1ye8A:
undetectable		 2jn3A-1ye8A:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		5 TYR A  14
LEU A  23
ALA A  31
ASP A  74
LEU A 118
 None
 0.93A 2jn3A-1zryA:
12.4		 2jn3A-1zryA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		6 TYR A  14
LEU A  23
ALA A  31
ILE A  34
THR A  53
LEU A 118
 None
 0.95A 2jn3A-1zryA:
12.4		 2jn3A-1zryA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A 434
ILE A 463
THR A 465
ASP A 475
LEU A 535
 None
 1.14A 2jn3A-2a8bA:
undetectable		 2jn3A-2a8bA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5

(Homo sapiens) 		PF00102
(Y_phosphatase) 		6 LEU A 317
ILE A 346
THR A 348
ASP A 358
ILE A 400
LEU A 418
 None
 1.10A 2jn3A-2bv5A:
undetectable		 2jn3A-2bv5A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A 930
ILE A 957
THR A 959
ASP A 969
LEU A1030
 None
 1.18A 2jn3A-2c7sA:
undetectable		 2jn3A-2c7sA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbi PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF01047
(MarR) 		5 LEU A  69
ALA A  55
GLN A  53
MET A  49
LEU A  72
 None
 1.15A 2jn3A-2fbiA:
undetectable		 2jn3A-2fbiA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		7 TYR A  14
LEU A  18
ALA A  31
ILE A  34
THR A  53
GLN A  56
HIS A  98
 None
None
OLA  A 130 (-3.3A)
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.4A)
OLA  A 130 ( 4.8A)
 1.12A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		7 TYR A  14
LEU A  18
ALA A  31
ILE A  34
THR A  53
HIS A  98
LEU A 118
 None
None
OLA  A 130 (-3.3A)
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.8A)
None
 0.82A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED

(Streptococcus
suis) 		PF01243
(Putative_PNPOx) 		5 LEU A  56
ALA A  83
ILE A 118
HIS A 103
ILE A 104
 None
 1.08A 2jn3A-2hhzA:
2.6		 2jn3A-2hhzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED

(Streptococcus
suis) 		PF01243
(Putative_PNPOx) 		5 LEU A  56
ALA A  83
ILE A 118
HIS A 103
LEU A  91
 None
 0.94A 2jn3A-2hhzA:
2.6		 2jn3A-2hhzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5v NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 10

(Homo sapiens) 		PF02758
(PYRIN) 		5 LEU A  15
LEU A  63
ALA A  72
THR A  38
LEU A  92
 None
 1.18A 2jn3A-2m5vA:
undetectable		 2jn3A-2m5vA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv5 PTPRD, PHOSPHATASE

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		5 LEU A1270
ILE A1297
THR A1299
ASP A1309
LEU A1371
 None
 1.14A 2jn3A-2nv5A:
0.3		 2jn3A-2nv5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU D  93
LEU D  40
ALA D  59
HIS D 112
ILE D 111
 None
 1.12A 2jn3A-2qe7D:
undetectable		 2jn3A-2qe7D:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A 789
ILE A 817
THR A 819
ASP A 829
LEU A 892
 None
 1.17A 2jn3A-2qepA:
undetectable		 2jn3A-2qepA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 LEU A 420
ALA A 252
ILE A 255
ILE A 403
LEU A   6
 None
 1.19A 2jn3A-2qfqA:
undetectable		 2jn3A-2qfqA:
15.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		6 TYR A  14
LEU A  18
ALA A  31
THR A  53
ASP A  74
HIS A  98
 None
CHD  A 130 ( 4.7A)
CHD  A 130 ( 3.8A)
CHD  A 130 ( 4.1A)
GOL  A 145 ( 2.8A)
IPA  A 140 (-3.7A)
 0.87A 2jn3A-2qo4A:
21.0		 2jn3A-2qo4A:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		5 LEU A 351
ALA A 211
ASP A 257
ILE A 324
LEU A 297
 None
 1.16A 2jn3A-2rfzA:
undetectable		 2jn3A-2rfzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzp PROTEIN KINASE C
GAMMA TYPE

(Homo sapiens) 		PF00168
(C2) 		5 LEU A 240
LEU A 163
THR A 212
ILE A 201
LEU A 200
 None
 1.07A 2jn3A-2uzpA:
undetectable		 2jn3A-2uzpA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		5 LEU A 491
LEU A 483
ALA A 481
ILE A 414
LEU A 493
 None
 1.07A 2jn3A-2vrkA:
undetectable		 2jn3A-2vrkA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypr PROTEIN FEV

(Homo sapiens) 		PF00178
(Ets) 		5 LEU A 101
ALA A 104
GLN A  48
ILE A  66
LEU A  77
 None
 1.07A 2jn3A-2yprA:
undetectable		 2jn3A-2yprA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy8 UPF0106 PROTEIN
PH0461

(Pyrococcus
horikoshii) 		PF01994
(Trm56) 		5 LEU A 138
ALA A  30
ILE A   2
ILE A 127
LEU A  80
 None
None
None
MTA  A 400 (-4.3A)
MTA  A 400 (-4.2A)
 1.13A 2jn3A-2yy8A:
undetectable		 2jn3A-2yy8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 406
ALA A 510
ILE A 388
HIS A 424
ILE A 461
 None
CSO  A 509 (-3.8A)
GOL  A 902 (-3.5A)
None
None
 1.02A 2jn3A-2z2wA:
undetectable		 2jn3A-2z2wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqe MUTS2 PROTEIN

(Thermus
thermophilus) 		PF01713
(Smr) 		5 LEU A  24
ALA A  27
HIS A  39
ILE A  50
LEU A  54
 None
 1.17A 2jn3A-2zqeA:
undetectable		 2jn3A-2zqeA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zym SOLUTE-BINDING
PROTEIN

(Thermoactinomyces
vulgaris) 		PF13416
(SBP_bac_8) 		5 LEU A  77
ILE A  49
THR A  47
ILE A  97
LEU A 286
 None
 1.16A 2jn3A-2zymA:
undetectable		 2jn3A-2zymA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4r NFATC2-INTERACTING
PROTEIN

(Mus musculus) 		PF11976
(Rad60-SLD) 		6 LEU A 341
LEU A  -2
ALA A 398
ASP A 361
ILE A 356
LEU A 343
 None
 1.18A 2jn3A-3a4rA:
undetectable		 2jn3A-3a4rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU B 231
ALA B 170
ILE B 164
HIS B  12
LEU B 196
 None
 1.14A 2jn3A-3al0B:
undetectable		 2jn3A-3al0B:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clj PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF04818
(CTD_bind) 		5 LEU A 136
ILE A  72
THR A  33
ASP A  78
ILE A 130
 None
 0.96A 2jn3A-3cljA:
undetectable		 2jn3A-3cljA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6y ESTERASE APC40077

(Oleispira
antarctica) 		PF00756
(Esterase) 		5 LEU A  55
ILE A 174
GLN A 230
ASP A  98
LEU A 191
 CL  A 280 (-3.6A)
None
None
None
None
 1.08A 2jn3A-3i6yA:
undetectable		 2jn3A-3i6yA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il0 XAA-PRO
AMINOPEPTIDASE
AMINOPEPTIDASE P

(Streptococcus
thermophilus) 		PF01321
(Creatinase_N) 		5 LEU A  88
ALA A  19
ASP A  86
ILE A  70
LEU A  51
 None
 0.83A 2jn3A-3il0A:
undetectable		 2jn3A-3il0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 608
ALA B 568
ILE B 571
ASP B 605
LEU B 613
 None
 1.12A 2jn3A-3kx2B:
undetectable		 2jn3A-3kx2B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls2 S-FORMYLGLUTATHIONE
HYDROLASE

(Pseudoalteromonas
haloplanktis) 		PF00756
(Esterase) 		5 LEU A  54
ILE A 173
GLN A 231
ASP A  97
LEU A 190
 None
 1.07A 2jn3A-3ls2A:
undetectable		 2jn3A-3ls2A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvp TETR/ACRR
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
mutans) 		PF00440
(TetR_N) 		5 ALA A  35
ILE A  52
THR A  49
ILE A 136
LEU A 132
 None
 1.18A 2jn3A-3mvpA:
undetectable		 2jn3A-3mvpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 ALA D 317
GLN D 343
HIS D 170
ILE D 166
LEU D 162
 None
 1.08A 2jn3A-3oaaD:
undetectable		 2jn3A-3oaaD:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rdj PROTEIN KINASE C
ALPHA TYPE

(Rattus
norvegicus) 		PF00168
(C2) 		5 LEU A 240
LEU A 164
THR A 212
ILE A 201
LEU A 200
 None
 1.09A 2jn3A-3rdjA:
undetectable		 2jn3A-3rdjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		5 LEU A 156
ALA A 118
ASP A 111
ILE A 195
LEU A 199
 None
 1.19A 2jn3A-3ta6A:
undetectable		 2jn3A-3ta6A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcq MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.13A 2jn3A-3tcqA:
undetectable		 2jn3A-3tcqA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 LEU A 348
ALA A 352
ILE A 217
HIS A 314
ILE A 313
 None
 1.18A 2jn3A-3vthA:
undetectable		 2jn3A-3vthA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		5 LEU A  52
ILE A 171
GLN A 227
ASP A  95
LEU A 188
 None
 1.10A 2jn3A-4b6gA:
undetectable		 2jn3A-4b6gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A1435
ILE A1462
THR A1464
ASP A1474
LEU A1536
 None
 1.13A 2jn3A-4bpcA:
undetectable		 2jn3A-4bpcA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		5 LEU A 188
ILE A 127
HIS A 280
ILE A 193
LEU A 192
 None
 1.09A 2jn3A-4ci0A:
undetectable		 2jn3A-4ci0A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		5 LEU A 235
LEU A 398
ILE A 247
THR A 263
ILE A 218
 None
SO4  A 605 (-4.6A)
None
None
None
 1.10A 2jn3A-4fwwA:
undetectable		 2jn3A-4fwwA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gft MYOSIN A TAIL DOMAIN
INTERACTING PROTEIN

(Plasmodium
falciparum) 		PF13405
(EF-hand_6) 		5 LEU A 203
ALA A 183
ASP A 201
ILE A 145
LEU A 144
 None
 1.00A 2jn3A-4gftA:
undetectable		 2jn3A-4gftA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		5 LEU A 383
ALA A 415
ILE A 431
HIS A 392
ILE A 391
 None
 1.11A 2jn3A-4ke4A:
undetectable		 2jn3A-4ke4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld8 MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.15A 2jn3A-4ld8A:
undetectable		 2jn3A-4ld8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		5 LEU D  93
ALA D  92
ILE D  85
ILE D 165
LEU D 166
 None
 0.94A 2jn3A-4mwaD:
undetectable		 2jn3A-4mwaD:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		5 LEU A 269
ALA A 311
ILE A 314
ASP A 268
LEU A 496
 None
 1.16A 2jn3A-4mzdA:
undetectable		 2jn3A-4mzdA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on1 PUTATIVE
METALLOPROTEASE II

(Bacteroides
fragilis) 		PF00413
(Peptidase_M10)
PF16376
(fragilysinNterm) 		5 LEU A  48
LEU A  40
ILE A  62
THR A  73
ILE A 104
 None
 1.13A 2jn3A-4on1A:
undetectable		 2jn3A-4on1A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on1 PUTATIVE
METALLOPROTEASE II

(Bacteroides
fragilis) 		PF00413
(Peptidase_M10)
PF16376
(fragilysinNterm) 		5 LEU A  48
LEU A  40
ILE A  62
THR A  73
LEU A 105
 None
 1.14A 2jn3A-4on1A:
undetectable		 2jn3A-4on1A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqa POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg)
PF05406
(WGR) 		5 LEU C 698
ILE C 643
THR C 556
HIS C 742
LEU C 768
 None
 1.07A 2jn3A-4oqaC:
0.9		 2jn3A-4oqaC:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 547
LEU A 649
ALA A 594
ILE A 633
LEU A 630
 None
 1.13A 2jn3A-4oqjA:
undetectable		 2jn3A-4oqjA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5x CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR1

(Homo sapiens) 		no annotation 5 TYR A 218
LEU A 277
ALA A 205
ASP A 276
LEU A 266
 None
 1.13A 2jn3A-4p5xA:
undetectable		 2jn3A-4p5xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		no annotation 5 LEU B 235
LEU B 398
ILE B 247
THR B 263
ILE B 218
 None
 1.14A 2jn3A-4qt8B:
undetectable		 2jn3A-4qt8B:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Homo sapiens) 		PF01704
(UDPGP) 		5 LEU A 108
ILE A 146
THR A 142
ILE A 263
LEU A 264
 None
 1.13A 2jn3A-4r7pA:
undetectable		 2jn3A-4r7pA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU A1748
ALA A1751
ILE A1349
ILE A1300
LEU A1304
 None
 1.19A 2jn3A-4r7yA:
undetectable		 2jn3A-4r7yA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Weissella
paramesenteroides) 		PF13377
(Peripla_BP_3) 		5 LEU A  82
ALA A 301
ILE A 143
ILE A  95
LEU A  93
 None
 1.14A 2jn3A-4rk6A:
undetectable		 2jn3A-4rk6A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		5 ILE B   8
THR B  38
ASP B 111
ILE B  25
LEU B  26
 None
None
MG  B 301 ( 4.1A)
None
None
 1.12A 2jn3A-4s1iB:
undetectable		 2jn3A-4s1iB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		5 LEU A 401
THR A 326
MET A 376
ASP A 378
LEU A  89
 None
 1.02A 2jn3A-4upiA:
undetectable		 2jn3A-4upiA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		5 LEU A  60
ALA A  69
ILE A  73
THR A  47
ILE A 466
 None
 1.17A 2jn3A-4y23A:
undetectable		 2jn3A-4y23A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 LEU A 231
ILE A 212
THR A 210
ILE A  54
LEU A  53
 None
 1.00A 2jn3A-5a22A:
undetectable		 2jn3A-5a22A:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 LEU A 119
LEU A 217
ALA A 222
ILE A  29
LEU A  30
 None
 1.08A 2jn3A-5aeeA:
2.1		 2jn3A-5aeeA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus) 		PF00946
(Mononeg_RNA_pol) 		5 LEU A 231
ILE A 212
THR A 210
ILE A  54
LEU A  53
 None
 1.18A 2jn3A-5chsA:
undetectable		 2jn3A-5chsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2j 4-OXALOCROTONATE
DECARBOXYLASE NAHK

(Pseudomonas
putida) 		no annotation 5 LEU A 182
LEU A 256
ILE A 138
ILE A 131
LEU A 209
 None
 1.19A 2jn3A-5d2jA:
undetectable		 2jn3A-5d2jA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep0 PUTATIVE REPRESSOR
PROTEIN LUXO

(Photobacterium
angustum) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 LEU A  55
LEU A  66
ALA A  93
ILE A  94
GLN A  99
 None
 1.06A 2jn3A-5ep0A:
undetectable		 2jn3A-5ep0A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		5 LEU A 462
ALA A 436
ILE A 438
ILE A 515
LEU A 520
 None
 1.16A 2jn3A-5esoA:
undetectable		 2jn3A-5esoA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		5 LEU A  52
ALA A  16
THR A 407
ILE A 199
LEU A 209
 None
 1.06A 2jn3A-5htpA:
undetectable		 2jn3A-5htpA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2c GATS-LIKE PROTEIN 3

(Homo sapiens) 		PF13840
(ACT_7) 		5 LEU A 113
ALA A  72
GLN A  70
HIS A 175
ILE A 280
 ARG  A 401 ( 4.9A)
None
None
None
ARG  A 401 (-3.9A)
 1.01A 2jn3A-5i2cA:
undetectable		 2jn3A-5i2cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A 264
LEU A 232
THR A 213
GLN A 214
ILE A 252
 None
 1.16A 2jn3A-5k8rA:
undetectable		 2jn3A-5k8rA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 LEU A 361
ILE A 369
THR A 492
ILE A 404
LEU A 350
 None
 1.03A 2jn3A-5lq3A:
undetectable		 2jn3A-5lq3A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noh TRANSCRIPTION
ELONGATION FACTOR
M2-1

(Human
orthopneumovirus) 		no annotation 5 LEU A  31
LEU A  77
ILE A  89
ILE A  39
LEU A  34
 None
 1.16A 2jn3A-5nohA:
undetectable		 2jn3A-5nohA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		5 LEU 5 113
ILE 5 314
THR 5 126
ILE 5 262
LEU 5 265
 None
 1.14A 2jn3A-5ool5:
undetectable		 2jn3A-5ool5:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		5 TYR A 297
LEU A  69
ALA A  73
ILE A 237
LEU A 236
 None
 1.16A 2jn3A-5uiwA:
undetectable		 2jn3A-5uiwA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Chaetomium
thermophilum) 		no annotation 5 LEU A   6
LEU A  51
ILE A  20
THR A 139
LEU A 159
 None
 1.16A 2jn3A-5w8mA:
undetectable		 2jn3A-5w8mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5) 		no annotation 5 LEU A 233
LEU A 171
ALA A 174
ILE A 219
MET A  76
 None
 1.11A 2jn3A-5wknA:
undetectable		 2jn3A-5wknA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 LEU A 421
ALA A 253
ILE A 256
THR A 322
ILE A 404
 None
 1.11A 2jn3A-5xwbA:
undetectable		 2jn3A-5xwbA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 5 LEU A1545
ALA A1311
HIS A1655
ILE A1656
LEU A1659
 None
 1.08A 2jn3A-6b3rA:
undetectable		 2jn3A-6b3rA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LEU A 174
PRO A 209
GLU A 438
ARG A 213
 None
 1.04A 2jn3A-1a2vA:
1.4		 2jn3A-1a2vA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A  45
LEU A 396
GLU A 259
ARG A  52
 None
 0.92A 2jn3A-1atiA:
0.0		 2jn3A-1atiA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Thermotoga
maritima) 		PF00121
(TIM) 		4 PHE A 190
LEU A 194
LEU A 195
GLU A 130
 None
 0.95A 2jn3A-1b9bA:
undetectable		 2jn3A-1b9bA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		4 LEU A  23
LEU A 117
GLU A  70
ARG A  89
 None
 0.63A 2jn3A-1cbfA:
0.0		 2jn3A-1cbfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 LEU A 380
LEU A 393
ARG A 121
GLU A 160
 None
 0.96A 2jn3A-1crzA:
0.0		 2jn3A-1crzA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 PHE A  10
LEU A  91
LEU A  98
PRO A 167
ARG A  72
 None
 1.41A 2jn3A-1e4oA:
undetectable		 2jn3A-1e4oA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens) 		PF01291
(LIF_OSM) 		4 PHE A  70
LEU A  14
GLU A  59
ARG A  63
 None
 0.94A 2jn3A-1evsA:
undetectable		 2jn3A-1evsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fgg GLUCURONYLTRANSFERAS
E I

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 PHE A 204
LEU A 100
LEU A 130
ARG A 201
 None
 0.99A 2jn3A-1fggA:
undetectable		 2jn3A-1fggA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw1 GLUTATHIONE
TRANSFERASE ZETA

(Homo sapiens) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		4 PHE A 139
LEU A 142
LEU A 146
GLU A 174
 None
 1.04A 2jn3A-1fw1A:
undetectable		 2jn3A-1fw1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A  45
LEU A 396
GLU A 259
ARG A  52
 None
 1.06A 2jn3A-1ggmA:
0.8		 2jn3A-1ggmA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 PHE A 557
LEU A 470
ARG A 583
GLU A 452
 None
 0.94A 2jn3A-1h17A:
undetectable		 2jn3A-1h17A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34

(Pisum sativum) 		PF04548
(AIG1) 		4 PHE A  17
LEU A  25
LEU A  26
GLU A  62
 None
 0.92A 2jn3A-1h65A:
undetectable		 2jn3A-1h65A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 LEU A 819
LEU A 797
GLU A 782
ARG A 692
 None
 0.79A 2jn3A-1hn0A:
2.6		 2jn3A-1hn0A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 LEU A 309
PRO A 197
GLU A 357
ARG A 326
 None
 1.06A 2jn3A-1j0hA:
undetectable		 2jn3A-1j0hA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		4 PHE A 268
LEU A 253
LEU A 254
ARG A 279
 None
 1.01A 2jn3A-1k7hA:
undetectable		 2jn3A-1k7hA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		4 PHE A 315
LEU A 323
GLU A 306
ARG A 311
 None
 0.99A 2jn3A-1k9xA:
undetectable		 2jn3A-1k9xA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kej TERMINAL
DEOXYNUCLEOTIDYLTRAN
SFERASE SHORT
ISOFORM

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 PHE A 456
LEU A 460
LEU A 472
GLU A 504
 None
 1.04A 2jn3A-1kejA:
undetectable		 2jn3A-1kejA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 LEU A 297
LEU A  28
PRO A 286
ARG A 289
 None
None
HEM  A 430 (-4.5A)
HEM  A 430 (-3.0A)
 1.01A 2jn3A-1lgfA:
undetectable		 2jn3A-1lgfA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 PHE A  51
LEU A 164
LEU A 169
PRO A 361
 None
 1.03A 2jn3A-1mkyA:
undetectable		 2jn3A-1mkyA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd N15 ALPHA-BETA
T-CELL RECEPTOR

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B  21
PRO B  61
GLU B  83
ARG B  64
 None
 1.07A 2jn3A-1nfdB:
undetectable		 2jn3A-1nfdB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 PHE A  13
LEU A  29
GLU A  10
ARG A  55
 None
 1.06A 2jn3A-1nsaA:
undetectable		 2jn3A-1nsaA:
16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		4 PHE A  17
LEU A  21
GLU A 110
ARG A 121
 None
 1.04A 2jn3A-1o1uA:
18.0		 2jn3A-1o1uA:
41.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 LEU A 780
PRO A 785
GLU A 676
ARG A 353
 None
 1.03A 2jn3A-1ogyA:
undetectable		 2jn3A-1ogyA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 LEU A 109
PRO A   8
GLU A  99
ARG A  88
 None
 0.96A 2jn3A-1qjcA:
undetectable		 2jn3A-1qjcA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		4 PHE A 581
LEU A 583
LEU A 553
GLU A 697
 None
 1.08A 2jn3A-1qu2A:
undetectable		 2jn3A-1qu2A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 LEU D 168
LEU D  62
PRO C  55
GLU C 118
ARG D 154
 None
None
AGS  C 803 (-4.1A)
AGS  C 803 ( 4.9A)
AGS  C 803 (-4.6A)
 1.46A 2jn3A-1sxjD:
undetectable		 2jn3A-1sxjD:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B 266
LEU B 103
PRO B 366
ARG B 110
 None
None
None
SO4  B3105 (-2.9A)
 0.98A 2jn3A-1t3qB:
undetectable		 2jn3A-1t3qB:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		4 LEU A 167
LEU A 174
ARG A 111
GLU A  94
 None
 0.97A 2jn3A-1tqxA:
undetectable		 2jn3A-1tqxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o VON WILLEBRAND
FACTOR

(Mus musculus) 		PF00092
(VWA) 		4 PHE C 536
LEU C 621
GLU C 689
ARG C 686
 None
 0.84A 2jn3A-1u0oC:
undetectable		 2jn3A-1u0oC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 LEU A 376
ARG A 303
GLU A 241
ARG A 237
 None
 1.06A 2jn3A-1vefA:
undetectable		 2jn3A-1vefA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 PHE A 449
LEU A 387
LEU A 423
PRO A 381
 None
 0.92A 2jn3A-1wdtA:
undetectable		 2jn3A-1wdtA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 369
LEU A 208
PRO A 386
GLU A 410
 None
 1.04A 2jn3A-1wytA:
undetectable		 2jn3A-1wytA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		4 PHE A 126
LEU A 228
LEU A 207
ARG A 198
 None
 0.68A 2jn3A-1x7pA:
undetectable		 2jn3A-1x7pA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		4 LEU A 762
LEU A 763
ARG A 724
ARG A 755
 None
 1.02A 2jn3A-1xfuA:
undetectable		 2jn3A-1xfuA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 PHE A 679
LEU A 660
LEU A 666
ARG A 673
 None
 1.04A 2jn3A-1y1uA:
undetectable		 2jn3A-1y1uA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y97 THREE PRIME REPAIR
EXONUCLEASE 2

(Homo sapiens) 		no annotation 4 LEU A 197
LEU A 172
GLU A 207
ARG A 204
 None
 1.01A 2jn3A-1y97A:
undetectable		 2jn3A-1y97A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 492
LEU A 569
GLU A 462
ARG A 480
 None
 0.90A 2jn3A-1yr2A:
undetectable		 2jn3A-1yr2A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		4 PHE A1521
LEU A1402
GLU A1323
ARG A1522
 None
 1.02A 2jn3A-1yrzA:
undetectable		 2jn3A-1yrzA:
14.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		4 LEU A  21
LEU A  23
GLU A 109
ARG A 120
 None
 0.94A 2jn3A-1zryA:
12.4		 2jn3A-1zryA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		4 LEU A  23
PRO A  36
GLU A 109
ARG A 120
 None
 1.00A 2jn3A-1zryA:
12.4		 2jn3A-1zryA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a35 HYPOTHETICAL PROTEIN
PA4017

(Pseudomonas
aeruginosa) 		PF08732
(HIM1) 		4 PHE A  70
LEU A 110
GLU A  28
ARG A  24
 None
 1.00A 2jn3A-2a35A:
undetectable		 2jn3A-2a35A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		4 LEU A 234
PRO A 143
ARG A 140
GLU A 155
 None
 0.96A 2jn3A-2amxA:
undetectable		 2jn3A-2amxA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayx SENSOR KINASE
PROTEIN RCSC

(Escherichia
coli) 		PF00072
(Response_reg)
PF09456
(RcsC) 		4 LEU A 726
LEU A 722
PRO A 808
GLU A 802
 None
 1.05A 2jn3A-2ayxA:
undetectable		 2jn3A-2ayxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		4 LEU A  55
PRO A 292
ARG A 298
ARG A  95
 None
 0.93A 2jn3A-2bb6A:
undetectable		 2jn3A-2bb6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 PHE A  83
LEU A 109
LEU A 110
PRO A 173
 None
 0.71A 2jn3A-2bklA:
undetectable		 2jn3A-2bklA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		4 LEU A  23
LEU A 117
GLU A  70
ARG A  89
 None
 0.69A 2jn3A-2cbfA:
undetectable		 2jn3A-2cbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjs UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2) 		4 PHE A  49
LEU A  26
LEU A  60
GLU A  46
 None
None
None
EDO  A1156 (-3.8A)
 1.04A 2jn3A-2cjsA:
undetectable		 2jn3A-2cjsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjt UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2) 		4 PHE A  49
LEU A  26
LEU A  60
GLU A  46
 FMT  A1139 ( 4.3A)
None
None
None
 1.05A 2jn3A-2cjtA:
undetectable		 2jn3A-2cjtA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		4 LEU A  38
LEU A  42
GLU A  63
ARG A  67
 None
 1.08A 2jn3A-2cu2A:
undetectable		 2jn3A-2cu2A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqw DIHYDROPTEROATE
SYNTHASE

(Thermus
thermophilus) 		PF00809
(Pterin_bind) 		4 LEU A  17
LEU A  19
GLU A 283
ARG A  28
 None
 1.06A 2jn3A-2dqwA:
undetectable		 2jn3A-2dqwA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		4 LEU A 524
ARG A 305
GLU A 273
ARG A 270
 None
 1.06A 2jn3A-2et6A:
undetectable		 2jn3A-2et6A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli) 		PF03602
(Cons_hypoth95) 		4 LEU A 114
PRO A 129
ARG A 131
GLU A  82
 None
 1.05A 2jn3A-2fpoA:
undetectable		 2jn3A-2fpoA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		4 LEU A  23
PRO A  36
GLU A 109
ARG A 120
 None
 0.80A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		4 PHE A  17
LEU A  23
PRO A  36
GLU A 109
 None
 0.79A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		4 LEU A 337
PRO A 209
GLU A 236
ARG A  64
 None
 1.07A 2jn3A-2greA:
undetectable		 2jn3A-2greA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 PHE A 224
LEU A 271
LEU A  97
ARG A 222
 None
None
None
SAM  A 801 (-3.3A)
 1.08A 2jn3A-2h21A:
undetectable		 2jn3A-2h21A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 PHE A 607
LEU A 611
LEU A 612
PRO A 116
 None
None
None
FAD  A 700 (-4.2A)
 0.96A 2jn3A-2i0kA:
undetectable		 2jn3A-2i0kA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PHE A 292
LEU A 301
LEU A 325
GLU A 288
 None
 0.89A 2jn3A-2id5A:
undetectable		 2jn3A-2id5A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 PHE A 187
LEU A 190
LEU A 194
GLU A 147
 None
 0.95A 2jn3A-2iyaA:
undetectable		 2jn3A-2iyaA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9r HOMEOBOX PROTEIN
NKX-3.1

(Homo sapiens) 		PF00046
(Homeobox) 		4 PHE A  52
LEU A  37
LEU A  41
ARG A  55
 None
 1.01A 2jn3A-2l9rA:
undetectable		 2jn3A-2l9rA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE

(Streptomyces
virginiae) 		PF00550
(PP-binding) 		4 PHE A6776
LEU A6766
ARG A6756
GLU A6741
 None
 1.02A 2jn3A-2mf4A:
undetectable		 2jn3A-2mf4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 LEU A 770
PRO A 775
GLU A 666
ARG A 343
 None
 1.03A 2jn3A-2nyaA:
undetectable		 2jn3A-2nyaA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		5 LEU A 376
LEU A 377
ARG A 647
GLU A 630
ARG A 626
 None
 1.43A 2jn3A-2o36A:
undetectable		 2jn3A-2o36A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o62 HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		PF12204
(DUF3598) 		4 LEU A 137
LEU A 213
GLU A 266
ARG A 247
 None
 1.06A 2jn3A-2o62A:
6.2		 2jn3A-2o62A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		4 PHE A 175
LEU A 184
LEU A 208
PRO A 219
 None
 1.07A 2jn3A-2o6qA:
undetectable		 2jn3A-2o6qA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 PHE A 505
LEU A 443
ARG A 554
ARG A 502
 None
 0.91A 2jn3A-2okxA:
undetectable		 2jn3A-2okxA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A1043
ARG A1089
GLU A1063
ARG A1065
 None
None
None
B3P  A 301 (-4.3A)
 1.07A 2jn3A-2ooqA:
undetectable		 2jn3A-2ooqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 LEU A 163
ARG A 225
GLU A 102
ARG A 109
 None
 0.79A 2jn3A-2optA:
undetectable		 2jn3A-2optA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		4 PHE A1006
LEU A1010
LEU A1011
GLU A1060
 None
 1.00A 2jn3A-2p3vA:
2.3		 2jn3A-2p3vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 PHE B 572
LEU A 357
LEU B 577
ARG A 287
 None
None
None
SO4  A 901 (-2.9A)
 0.97A 2jn3A-2pjrB:
undetectable		 2jn3A-2pjrB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 PHE A 188
LEU A 183
LEU A 182
PRO A  72
 None
 0.97A 2jn3A-2plaA:
undetectable		 2jn3A-2plaA:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 PHE A  17
LEU A  23
PRO A  36
GLU A 109
ARG A 120
 None
CHD  A 130 ( 4.6A)
None
None
CHD  A 130 (-3.4A)
 0.72A 2jn3A-2qo4A:
21.0		 2jn3A-2qo4A:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsy TYROSINE-PROTEIN
KINASE CSK

(Rattus
norvegicus) 		PF00017
(SH2) 		4 PHE A  83
LEU A 149
LEU A 152
ARG A 107
 None
None
None
PTR  B 314 ( 4.4A)
 0.99A 2jn3A-2rsyA:
undetectable		 2jn3A-2rsyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		4 LEU A 388
LEU A 456
PRO A  35
ARG A 507
 None
None
PO4  A1541 (-4.4A)
None
 1.00A 2jn3A-2vl7A:
undetectable		 2jn3A-2vl7A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 405
LEU A 571
PRO A 435
GLU A 522
 None
 0.87A 2jn3A-2vwkA:
undetectable		 2jn3A-2vwkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 117
LEU A 253
GLU A 114
ARG A 116
 None
 0.96A 2jn3A-2w2jA:
1.2		 2jn3A-2w2jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 LEU A  26
LEU A  23
PRO A 105
ARG A 113
 None
 0.91A 2jn3A-2x3kA:
undetectable		 2jn3A-2x3kA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 LEU A 374
LEU A 365
GLU A 348
ARG A 432
 None
 0.87A 2jn3A-2y4oA:
undetectable		 2jn3A-2y4oA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykq LINE-1 ORF1P

(Homo sapiens) 		PF02994
(Transposase_22)
PF17489
(Tnp_22_trimer)
PF17490
(Tnp_22_dsRBD) 		4 LEU A 249
PRO A 214
GLU A 169
ARG A 202
 None
 1.03A 2jn3A-2ykqA:
undetectable		 2jn3A-2ykqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PHE A 171
LEU A 180
LEU A 208
GLU A 142
 None
 0.95A 2jn3A-2z65A:
undetectable		 2jn3A-2z65A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF08839
(CDT1) 		4 LEU C 298
LEU C 303
GLU C 225
ARG C 223
 None
 1.06A 2jn3A-2zxxC:
undetectable		 2jn3A-2zxxC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 406
LEU A 572
PRO A 436
GLU A 523
 None
 1.06A 2jn3A-3a2fA:
undetectable		 2jn3A-3a2fA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I

(Legionella
pneumophila) 		PF01150
(GDA1_CD39) 		4 PHE A 309
LEU A 321
LEU A 316
PRO A 378
 None
 1.06A 2jn3A-3aarA:
undetectable		 2jn3A-3aarA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		4 PHE A 466
LEU A 437
ARG A 449
GLU A 359
 None
None
None
CA  A 488 (-3.4A)
 1.06A 2jn3A-3c7oA:
undetectable		 2jn3A-3c7oA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ced METHIONINE IMPORT
ATP-BINDING PROTEIN
METN 2

(Staphylococcus
aureus) 		PF09383
(NIL) 		4 PHE A 270
LEU A 309
LEU A 311
ARG A 331
 None
 0.99A 2jn3A-3cedA:
undetectable		 2jn3A-3cedA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF01636
(APH) 		4 PHE A 189
LEU A 226
LEU A 227
ARG A 258
 None
 0.96A 2jn3A-3csvA:
undetectable		 2jn3A-3csvA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		5 PHE A 313
PRO A 319
ARG A 324
GLU A 274
ARG A 280
 None
 1.49A 2jn3A-3dhuA:
2.2		 2jn3A-3dhuA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		4 PHE A 312
LEU A 320
GLU A 303
ARG A 308
 None
 0.98A 2jn3A-3dwcA:
undetectable		 2jn3A-3dwcA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ein GLUTATHIONE
S-TRANSFERASE 1-1

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 PHE A 135
LEU A 138
LEU A 142
GLU A 168
 None
 0.97A 2jn3A-3einA:
undetectable		 2jn3A-3einA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoj BACTERIOCHLOROPHYLL
A PROTEIN

(Prosthecochloris
aestuarii) 		PF02327
(BChl_A) 		4 LEU A 292
ARG A 125
GLU A 361
ARG A 286
 EDO  A 389 ( 4.4A)
None
None
None
 1.08A 2jn3A-3eojA:
undetectable		 2jn3A-3eojA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewn THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF01965
(DJ-1_PfpI) 		4 PHE A 211
LEU A 160
GLU A 218
ARG A 195
 None
 1.02A 2jn3A-3ewnA:
undetectable		 2jn3A-3ewnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 PHE A 215
LEU A 217
LEU A 129
ARG A  73
 None
 0.83A 2jn3A-3f41A:
undetectable		 2jn3A-3f41A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbf PHPD

(Streptomyces
viridochromogenes) 		no annotation 4 LEU A 367
LEU A 380
PRO A 110
GLU A 355
 None
 1.03A 2jn3A-3gbfA:
undetectable		 2jn3A-3gbfA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 374
LEU A 369
GLU A 270
ARG A 310
 None
 1.05A 2jn3A-3hhdA:
undetectable		 2jn3A-3hhdA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 PHE A 450
LEU A 454
LEU A 424
ARG A 443
 None
 1.03A 2jn3A-3hhdA:
undetectable		 2jn3A-3hhdA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hk0 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		4 LEU A 227
LEU A 223
GLU A 167
ARG A 337
 None
None
None
SCN  A  15 (-3.8A)
 0.98A 2jn3A-3hk0A:
undetectable		 2jn3A-3hk0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htv D-ALLOSE KINASE

(Escherichia
coli) 		PF00480
(ROK) 		4 PHE A  20
LEU A  22
LEU A  30
GLU A  51
 None
 1.02A 2jn3A-3htvA:
undetectable		 2jn3A-3htvA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 PHE A 678
LEU A 627
LEU A 629
GLU A 645
 None
 1.01A 2jn3A-3hvdA:
undetectable		 2jn3A-3hvdA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knw PUTATIVE
TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)

(Acinetobacter
sp. ADP1) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		4 PHE A  58
LEU A  62
LEU A  63
GLU A  36
 None
 0.97A 2jn3A-3knwA:
undetectable		 2jn3A-3knwA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		4 LEU A  80
LEU A  77
GLU A  98
ARG A  49
 None
 1.03A 2jn3A-3mq2A:
undetectable		 2jn3A-3mq2A:
17.22