SIMILAR PATTERNS OF AMINO ACIDS FOR 2JKL_C_CLMC1143_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad9 IGG CTM01 FAB (HEAVY
CHAIN)

(Homo sapiens) 		no annotation 5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.13A 2jklC-1ad9H:
1.0		 2jklC-1ad9H:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cic PROTEIN (IG HEAVY
CHAIN V REGIONS)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.88A 2jklC-1cicB:
undetectable		 2jklC-1cicB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de4 HEMOCHROMATOSIS
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 PRO A 236
GLY A 238
GLY A 240
TYR A 242
 None
 0.65A 2jklC-1de4A:
undetectable		 2jklC-1de4A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		4 GLY A 272
THR A 161
ILE A 277
GLY A 274
 None
 0.84A 2jklC-1f0iA:
0.0		 2jklC-1f0iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1for IGG2A-KAPPA 17-IA
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.75A 2jklC-1forH:
0.0		 2jklC-1forH:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.14A 2jklC-1fptH:
1.3		 2jklC-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx7 IRON-DEPENDENT
REPRESSOR IDER

(Mycobacterium
tuberculosis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		4 GLY A 202
PRO A 201
THR A 216
GLY A 204
 None
None
SO4  A1017 (-3.9A)
None
 0.87A 2jklC-1fx7A:
undetectable		 2jklC-1fx7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iaw TYPE II RESTRICTION
ENZYME NAEI

(Lechevalieria
aerocolonigenes) 		PF09126
(NaeI) 		4 PRO A 267
GLY A 270
ILE A 218
GLY A 214
 None
 0.84A 2jklC-1iawA:
undetectable		 2jklC-1iawA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ieh BRUC.D4.4

(Lama glama) 		PF07686
(V-set) 		5 GLY A  54
PRO A  53
THR A  58
ILE A  51
GLY A  56
 None
 1.41A 2jklC-1iehA:
1.5		 2jklC-1iehA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr RUVB

(Thermus
thermophilus) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		4 GLY C  63
THR C 140
ILE C  93
GLY C  91
 None
 0.86A 2jklC-1ixrC:
undetectable		 2jklC-1ixrC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv5 IG CHAIN HEAVY CHAIN
PRECURSOR V REGION

(Homo sapiens) 		PF07686
(V-set) 		5 GLY B 354
PRO B 353
THR B 358
ILE B 351
GLY B 356
 None
 1.08A 2jklC-1jv5B:
undetectable		 2jklC-1jv5B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.79A 2jklC-1ko0A:
undetectable		 2jklC-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.86A 2jklC-1lqtA:
undetectable		 2jklC-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mex FAB 29G12 HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.80A 2jklC-1mexH:
undetectable		 2jklC-1mexH:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mj8 IMMUNOGLOBULIN
MS6-126

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.88A 2jklC-1mj8H:
2.0		 2jklC-1mj8H:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		4 GLY A 134
PRO A 133
THR A  33
GLY A 169
 None
 0.83A 2jklC-1p3cA:
undetectable		 2jklC-1p3cA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1plg IGG2A=KAPPA=

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  54
PRO H  53
THR H  58
ILE H  51
GLY H  56
 None
 1.13A 2jklC-1plgH:
undetectable		 2jklC-1plgH:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0y FAB 9B1, HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.11A 2jklC-1q0yH:
undetectable		 2jklC-1q0yH:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PRO A 429
GLY A 377
THR A 132
ILE A 396
 None
 0.83A 2jklC-1qgdA:
undetectable		 2jklC-1qgdA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvf FAB 17-IA

(Mus musculus) 		PF07686
(V-set) 		4 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.74A 2jklC-1rvfH:
undetectable		 2jklC-1rvfH:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN

(Sulfurisphaera
tokodaii) 		PF01950
(FBPase_3) 		4 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.83A 2jklC-1umgA:
undetectable		 2jklC-1umgA:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ut1 DR HEMAGGLUTININ
STRUCTURAL SUBUNIT

(Escherichia
coli) 		PF04619
(Adhesin_Dr) 		7 PRO A  40
GLY A  42
PRO A  43
THR A  88
ILE A 111
GLY A 113
TYR A 115
 EDO  A1143 ( 4.3A)
None
None
None
None
None
None
 0.51A 2jklC-1ut1A:
27.2		 2jklC-1ut1A:
99.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wt5 ANTI EGFR ANTIBODY
FV REGION

(Homo sapiens) 		PF07686
(V-set) 		5 GLY A  54
PRO A  53
THR A  58
ILE A  51
GLY A  56
 None
 1.16A 2jklC-1wt5A:
undetectable		 2jklC-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yed IGG1 FAB FRAGMENT
(D.2.4)

(Mus musculus) 		no annotation 5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.11A 2jklC-1yedH:
undetectable		 2jklC-1yedH:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yee IGG2A FAB FRAGMENT
(D2.5)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.86A 2jklC-1yeeH:
undetectable		 2jklC-1yeeH:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		4 GLY A 101
THR A  60
ILE A  64
GLY A  66
 None
 0.52A 2jklC-1zupA:
undetectable		 2jklC-1zupA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF03562
(MltA)
PF06725
(3D) 		4 PRO X 104
GLY X 314
PRO X 315
GLY X 318
 None
 0.83A 2jklC-2ae0X:
undetectable		 2jklC-2ae0X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czt PROSTAGLANDIN-H2
D-ISOMERASE

(Mus musculus) 		PF00061
(Lipocalin) 		4 PRO A  98
PRO A 102
GLY A 103
TYR A 105
 None
 0.58A 2jklC-2cztA:
undetectable		 2jklC-2cztA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 GLY H  53
PRO H 521
THR H  57
ILE H  51
GLY H  55
 None
 1.11A 2jklC-2e27H:
undetectable		 2jklC-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh7 HUMANIZED KR127 FAB,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.12A 2jklC-2eh7H:
undetectable		 2jklC-2eh7H:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 PRO A 522
ILE A 504
GLY A 506
TYR A 508
 None
 0.62A 2jklC-2eyqA:
undetectable		 2jklC-2eyqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		4 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.79A 2jklC-2gp4A:
undetectable		 2jklC-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 GLY A 279
PRO A 280
THR A 306
GLY A 303
 SO4  A1504 (-3.1A)
SO4  A1504 (-4.6A)
None
FMN  A1401 (-4.1A)
 0.81A 2jklC-2h8xA:
undetectable		 2jklC-2h8xA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.80A 2jklC-2jisA:
undetectable		 2jklC-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb7 E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.53A 2jklC-2pb7A:
undetectable		 2jklC-2pb7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PRO A1071
GLY A1069
GLY A1074
TYR A1072
 None
 0.75A 2jklC-2pffA:
undetectable		 2jklC-2pffA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.73A 2jklC-2r4sH:
1.5		 2jklC-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		4 GLY A  43
PRO A  44
ILE A 194
GLY A  45
 MLI  A   2 (-3.5A)
None
None
None
 0.79A 2jklC-2ri6A:
undetectable		 2jklC-2ri6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwe ANTI-VEGF-B
MONOCLONAL ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY E  53
PRO E  52
THR E  57
ILE E  51
GLY E  55
 None
 1.22A 2jklC-2vweE:
undetectable		 2jklC-2vweE:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x27 OUTER MEMBRANE
PROTEIN OPRG

(Pseudomonas
aeruginosa) 		PF03922
(OmpW) 		4 GLY X 137
THR X 191
ILE X 180
GLY X 182
 None
 0.78A 2jklC-2x27X:
undetectable		 2jklC-2x27X:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 PRO A 252
GLY A 254
PRO A 255
ILE A 227
 None
 0.67A 2jklC-2y05A:
undetectable		 2jklC-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.83A 2jklC-2y27A:
undetectable		 2jklC-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.78A 2jklC-2y4oA:
undetectable		 2jklC-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.09A 2jklC-2z4qB:
undetectable		 2jklC-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.51A 2jklC-3a9gA:
undetectable		 2jklC-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdi UNCHARACTERIZED
PROTEIN TA0194

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1)
PF12146
(Hydrolase_4) 		4 PRO A 132
GLY A 111
ILE A 103
GLY A 105
 None
 0.82A 2jklC-3bdiA:
undetectable		 2jklC-3bdiA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esu ANTIBODY 14B7* LIGHT
CHAIN AND ANTIBODY
14B7* HEAVY CHAIN
LINKED WITH A
SYNTHETIC (GGGGS)4
LINKER

(Mus musculus) 		PF07686
(V-set) 		5 GLY F1053
PRO F1052
THR F1057
ILE F1051
GLY F1055
 None
 1.12A 2jklC-3esuF:
undetectable		 2jklC-3esuF:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		4 PRO A  29
GLY A   9
THR A  24
GLY A  11
 None
 0.88A 2jklC-3fsxA:
undetectable		 2jklC-3fsxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 PRO A  42
GLY A  13
ILE A   9
GLY A  11
 FAD  A 902 (-4.8A)
FAD  A 902 (-3.1A)
None
FAD  A 902 (-3.2A)
 0.87A 2jklC-3gsiA:
undetectable		 2jklC-3gsiA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8v H16.14J HEAVY CHAIN

(Mus musculus) 		no annotation 5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.04A 2jklC-3j8vH:
undetectable		 2jklC-3j8vH:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8w H263.A2 HEAVY CHAIN

(Mus musculus) 		no annotation 5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.13A 2jklC-3j8wH:
undetectable		 2jklC-3j8wH:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8z H16.1A HEAVY CHAIN

(Mus musculus) 		no annotation 5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.14A 2jklC-3j8zH:
undetectable		 2jklC-3j8zH:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntc FAB HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.15A 2jklC-3ntcH:
2.1		 2jklC-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz8 MOUSE ANTI V3
ANTIBODY 7C8 FAB,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY A  53
PRO A  52
ILE A  51
GLY A  55
 None
 0.84A 2jklC-3nz8A:
undetectable		 2jklC-3nz8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.72A 2jklC-3ps9A:
undetectable		 2jklC-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 690 (-3.3A)
None
FAD  A 690 (-3.3A)
 0.82A 2jklC-3pvcA:
undetectable		 2jklC-3pvcA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qum FAB 5D3D11 HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.17A 2jklC-3qumH:
undetectable		 2jklC-3qumH:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		4 GLY A 389
PRO A 390
ILE A 327
GLY A 284
 None
 0.76A 2jklC-3rh9A:
undetectable		 2jklC-3rh9A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 PRO A 148
GLY A 146
THR A 193
GLY A 144
 COA  A 601 (-4.8A)
None
None
None
 0.81A 2jklC-3sqzA:
undetectable		 2jklC-3sqzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		4 GLY A 360
PRO A 331
GLY A 332
TYR A 362
 None
 0.83A 2jklC-3t3oA:
undetectable		 2jklC-3t3oA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt1 MOUSE MONOCLONAL
1GG2A FAB FRAGMENT,
KAPPA LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  54
PRO H  53
THR H  58
ILE H  51
GLY H  56
 None
 1.14A 2jklC-3tt1H:
undetectable		 2jklC-3tt1H:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti) 		PF03486
(HI0933_like) 		4 PRO A  40
GLY A  14
ILE A  10
GLY A  12
 None
FDA  A 547 (-3.4A)
None
FDA  A 547 (-3.4A)
 0.81A 2jklC-3v76A:
undetectable		 2jklC-3v76A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbd SINGLE CHAIN FV
FRAGMENT OF MAB735

(Mus musculus) 		PF07686
(V-set) 		5 GLY A 181
PRO A 180
THR A 185
ILE A 178
GLY A 183
 None
 1.14A 2jklC-3wbdA:
undetectable		 2jklC-3wbdA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		4 GLY A 274
PRO A 273
THR A  71
GLY A 655
 None
None
None
TYR  A 802 (-3.8A)
 0.86A 2jklC-3wonA:
undetectable		 2jklC-3wonA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ala FAB 2H12 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.81A 2jklC-4alaH:
2.2		 2jklC-4alaH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmh HEAVY CHAIN OF
SAR650984-FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.11A 2jklC-4cmhB:
undetectable		 2jklC-4cmhB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 GLY A 454
THR A 459
ILE A 433
GLY A 456
 None
 0.83A 2jklC-4f4cA:
undetectable		 2jklC-4f4cA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2) 		4 GLY E 443
PRO E 444
THR E 496
GLY E 493
 None
 0.85A 2jklC-4f52E:
undetectable		 2jklC-4f52E:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmk RIBOSE-5-PHOSPHATE
ISOMERASE A

(Lactobacillus
salivarius) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 220
PRO A 221
ILE A 214
GLY A 216
 None
 0.65A 2jklC-4gmkA:
undetectable		 2jklC-4gmkA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8r HEAVY CHAIN OF POM2
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  53
PRO B  52
THR B  57
ILE B  51
GLY B  55
 None
 1.16A 2jklC-4j8rB:
undetectable		 2jklC-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kaq RITUXIMAB HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  54
PRO H  53
THR H  58
ILE H  51
GLY H  56
 None
 1.09A 2jklC-4kaqH:
1.4		 2jklC-4kaqH:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY E  54
PRO E  53
THR E  58
ILE E  51
GLY E  56
 GLY  E  54 ( 0.0A)
PRO  E  53 ( 1.1A)
THR  E  58 ( 0.8A)
ILE  E  51 ( 0.7A)
GLY  E  56 ( 0.0A)
 1.12A 2jklC-4ki5E:
undetectable		 2jklC-4ki5E:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuc MAB6C2 FAB-LIGHT
CHAIN

(Mus musculus) 		no annotation 5 GLY H  73
PRO H  72
THR H  77
ILE H  70
GLY H  75
 None
 1.14A 2jklC-4kucH:
undetectable		 2jklC-4kucH:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 GLY A  47
PRO A  48
ILE A  52
TYR A 146
 None
 0.84A 2jklC-4mo9A:
undetectable		 2jklC-4mo9A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		4 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.79A 2jklC-4mt1A:
undetectable		 2jklC-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqe MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS
I-RELATED GENE
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 PRO A 232
GLY A 234
GLY A 236
TYR A 238
 None
 0.83A 2jklC-4nqeA:
undetectable		 2jklC-4nqeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.63A 2jklC-4nsxA:
undetectable		 2jklC-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uok FAB FRAGMENT HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY A 272
PRO A 271
THR A 276
ILE A 269
GLY A 274
 None
 1.13A 2jklC-4uokA:
undetectable		 2jklC-4uokA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis) 		no annotation 4 GLY A 721
PRO A 722
ILE A 600
GLY A 725
 FMN  A 900 ( 4.8A)
None
None
None
 0.88A 2jklC-4z38A:
undetectable		 2jklC-4z38A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfq L,D-TRANSPEPTIDASE 5

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 PRO A 242
GLY A 244
GLY A 246
TYR A 248
 None
 0.69A 2jklC-4zfqA:
undetectable		 2jklC-4zfqA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zso ANTIBODY HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.16A 2jklC-4zsoB:
undetectable		 2jklC-4zsoB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfe EXODEOXYRIBONUCLEASE

(Bacillus
subtilis) 		PF03372
(Exo_endo_phos) 		4 GLY A  82
THR A  94
ILE A  78
GLY A  80
 PEG  A 303 (-3.5A)
None
PEG  A 303 (-4.2A)
None
 0.88A 2jklC-5cfeA:
undetectable		 2jklC-5cfeA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.06A 2jklC-5cmaB:
undetectable		 2jklC-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3j ANTIBODY 2D10 SINGLE
CHAIN VARIABLE
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 GLY C 223
PRO C 222
THR C 227
ILE C 220
GLY C 225
 None
 1.17A 2jklC-5f3jC:
2.2		 2jklC-5f3jC:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLY C 218
THR C 174
ILE C 180
GLY C 198
 None
 0.87A 2jklC-5fseC:
undetectable		 2jklC-5fseC:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		4 GLY A 204
THR A 127
ILE A 123
TYR A 206
 None
 0.82A 2jklC-5fsgA:
undetectable		 2jklC-5fsgA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		4 PRO A 207
GLY A 204
THR A 127
ILE A 123
 None
 0.83A 2jklC-5fsgA:
undetectable		 2jklC-5fsgA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		4 PRO A 604
GLY A 606
GLY A 608
TYR A 610
 None
 0.80A 2jklC-5g56A:
3.4		 2jklC-5g56A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 GLY A 419
THR A 442
ILE A 434
GLY A 436
 None
 0.79A 2jklC-5ic7A:
undetectable		 2jklC-5ic7A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie6 ZEARALENONE
HYDROLASE

(Clonostachys
rosea) 		PF00561
(Abhydrolase_1) 		4 GLY A 240
PRO A 239
THR A 211
GLY A 213
 None
 0.78A 2jklC-5ie6A:
undetectable		 2jklC-5ie6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		4 GLY A 277
PRO A 276
THR A  70
GLY A 653
 None
 0.79A 2jklC-5jwfA:
undetectable		 2jklC-5jwfA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 GLY A 269
PRO A 268
THR A  68
GLY A 642
 None
None
None
ASP  A 802 (-3.8A)
 0.85A 2jklC-5jxfA:
undetectable		 2jklC-5jxfA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvd ZV-2 ANTIBODY FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.12A 2jklC-5kvdH:
1.3		 2jklC-5kvdH:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjk THIOREDOXIN
REDUCTASE

(Lactococcus
lactis) 		PF07992
(Pyr_redox_2) 		4 PRO A  39
GLY A  14
ILE A  10
GLY A  12
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 (-3.3A)
 0.88A 2jklC-5mjkA:
undetectable		 2jklC-5mjkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myx FAB C#24 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.11A 2jklC-5myxB:
undetectable		 2jklC-5myxB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 GLY A 517
THR A 473
ILE A 493
GLY A 495
 None
 0.83A 2jklC-5t98A:
3.6		 2jklC-5t98A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlp FAB7G7 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  54
PRO H  53
THR H  58
ILE H  51
GLY H  56
 None
 1.23A 2jklC-5vlpH:
undetectable		 2jklC-5vlpH:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5x 3C10 FAB' HEAVY
CHAIN

(Rattus
norvegicus) 		no annotation 5 GLY H  54
PRO H  53
THR H  58
ILE H  51
GLY H  56
 None
 1.08A 2jklC-5w5xH:
undetectable		 2jklC-5w5xH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 4 GLY A 588
THR A 557
ILE A 592
GLY A 590
 None
 0.88A 2jklC-5z9sA:
undetectable		 2jklC-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 4 GLY A 265
ILE A 411
GLY A 327
TYR A 262
 None
 0.87A 2jklC-6bs7A:
undetectable		 2jklC-6bs7A:
undetectable