SIMILAR PATTERNS OF AMINO ACIDS FOR 2JJP_A_KLNA413_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00652
(Ricin_B_lectin) 		5 PRO B  14
ALA B  90
ALA B  92
THR B  71
ILE B  62
 NDG  B 273 (-3.7A)
None
None
None
None
 1.29A 2jjpA-1abrB:
0.0		 2jjpA-1abrB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 LEU A 161
ALA A 100
THR A 128
GLN A 146
ILE A 147
 None
 1.18A 2jjpA-1ao0A:
0.0		 2jjpA-1ao0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)

(Escherichia
coli) 		PF00490
(ALAD) 		5 ALA A 157
ALA A 155
THR A 187
MET A  77
ILE A 114
 None
 1.22A 2jjpA-1b4eA:
0.0		 2jjpA-1b4eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ALA A 211
LEU A 214
ALA A 215
GLN A 176
ILE A 181
 None
 0.94A 2jjpA-1bf2A:
0.0		 2jjpA-1bf2A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		5 ALA A 107
ALA A 104
THR A 100
GLN A 138
GLN A 140
 None
 1.11A 2jjpA-1bt4A:
0.0		 2jjpA-1bt4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 ALA A 101
ALA A 104
THR A 107
PHE A1401
ILE A 116
 None
 1.26A 2jjpA-1cj0A:
0.0		 2jjpA-1cj0A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djp GLUTAMINASE-ASPARAGI
NASE

(Pseudomonas sp.
7A) 		PF00710
(Asparaginase) 		5 ALA A1240
LEU A1241
ALA A1242
THR A1275
GLN A1295
 None
 1.17A 2jjpA-1djpA:
0.0		 2jjpA-1djpA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		5 ALA A  30
ALA A  26
PHE A  55
GLN A  40
ILE A  49
 None
 1.13A 2jjpA-1ecoA:
undetectable		 2jjpA-1ecoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PRO A 389
LEU A 359
ALA A 423
THR A 430
ILE A 351
 None
 1.21A 2jjpA-1g7cA:
undetectable		 2jjpA-1g7cA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1je6 MHC CLASS I
CHAIN-RELATED
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ALA A 135
LEU A 138
ALA A 139
THR A 143
GLN A  91
 None
 1.09A 2jjpA-1je6A:
0.0		 2jjpA-1je6A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		5 ALA A 537
LEU A 540
ALA A 541
GLN A 443
ILE A 442
 None
 1.19A 2jjpA-1jqkA:
undetectable		 2jjpA-1jqkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 PRO A  63
ALA A  87
LEU A  86
ALA A  83
ILE A  68
 None
 1.16A 2jjpA-1la2A:
undetectable		 2jjpA-1la2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		5 HIS A 301
LEU A 162
ALA A 161
THR A 137
GLN A 263
 None
 1.20A 2jjpA-1mtpA:
undetectable		 2jjpA-1mtpA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0e PROTEIN MRAZ

(Mycoplasma
pneumoniae) 		PF02381
(MraZ) 		5 PRO A 115
ALA A  45
LEU A  47
ALA A  49
ILE A  55
 None
 1.17A 2jjpA-1n0eA:
undetectable		 2jjpA-1n0eA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ALA A 811
LEU A 814
ALA A 815
THR A 819
GLN A 626
 None
 0.98A 2jjpA-1n5xA:
undetectable		 2jjpA-1n5xA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 ALA C 221
LEU C 232
ALA C 233
GLN C  53
GLN C  75
 None
 1.27A 2jjpA-1n8yC:
undetectable		 2jjpA-1n8yC:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 ALA A 193
ALA A 132
THR A 109
PHE A 113
MET A 128
 None
 1.13A 2jjpA-1q5aA:
undetectable		 2jjpA-1q5aA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF

(Pseudomonas
fluorescens) 		PF02567
(PhzC-PhzF) 		5 PRO A  31
ALA A  82
LEU A  83
ALA A  80
GLN A  97
 None
 1.21A 2jjpA-1t6kA:
undetectable		 2jjpA-1t6kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		5 MET A 141
ALA A 111
LEU A 112
ALA A 113
MET A 208
 PHE  A 300 ( 4.9A)
None
None
None
None
 1.30A 2jjpA-1xqwA:
undetectable		 2jjpA-1xqwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvd RAS-RELATED PROTEIN
RAB-22A

(Mus musculus) 		PF00071
(Ras) 		5 ALA A  69
LEU A  70
ALA A  71
THR A  61
ILE A  38
 None
 1.21A 2jjpA-1yvdA:
undetectable		 2jjpA-1yvdA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g40 CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02589
(LUD_dom) 		5 ALA A  74
LEU A  75
ALA A  72
THR A  93
ILE A  87
 None
 1.09A 2jjpA-2g40A:
undetectable		 2jjpA-2g40A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2goy ADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01507
(PAPS_reduct) 		5 ALA A  34
LEU A  37
ALA A  38
GLN A 166
GLN A 162
 None
 1.29A 2jjpA-2goyA:
undetectable		 2jjpA-2goyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 ALA A 141
LEU A 138
ALA A 139
PHE A  49
ILE A 135
 None
89I  A 500 (-4.4A)
None
None
None
 0.97A 2jjpA-2i6bA:
undetectable		 2jjpA-2i6bA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE

(Archaeoglobus
fulgidus) 		PF00730
(HhH-GPD) 		5 ALA A 136
LEU A 139
PHE A 161
GLN A 164
ILE A 167
 None
 1.24A 2jjpA-2jhnA:
undetectable		 2jjpA-2jhnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kin KINESIN

(Rattus
norvegicus) 		PF00225
(Kinesin) 		5 ALA B 268
LEU B 269
ALA B 270
THR B 326
ILE B 300
 None
 1.01A 2jjpA-2kinB:
undetectable		 2jjpA-2kinB:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3e MAJOR AMPULLATE
SPIDROIN 1

(Latrodectus
hesperus) 		PF16763
(Spidroin_N) 		5 ALA A  91
ALA A  95
PHE A  70
GLN A  76
ILE A  43
 None
 1.21A 2jjpA-2n3eA:
undetectable		 2jjpA-2n3eA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 MET A 229
PRO A 220
ALA A 277
LEU A 280
ALA A 281
 None
 1.11A 2jjpA-2p88A:
undetectable		 2jjpA-2p88A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		5 ALA A 190
LEU A 193
ALA A 194
THR A 198
ILE A 131
 None
 0.74A 2jjpA-2pjqA:
undetectable		 2jjpA-2pjqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3n AGGLUTININ-1 B CHAIN

(Abrus
precatorius) 		PF00652
(Ricin_B_lectin) 		5 PRO B  14
ALA B  90
ALA B  92
THR B  71
ILE B  62
 None
 1.27A 2jjpA-2q3nB:
undetectable		 2jjpA-2q3nB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 PRO A  33
ALA A 136
ALA A 140
THR A 143
GLN A  96
 None
 1.27A 2jjpA-2qriA:
undetectable		 2jjpA-2qriA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 HIS A 252
ALA A 227
LEU A 228
ALA A 225
THR A 196
 None
None
None
UAG  A1498 ( 4.8A)
UAG  A1498 (-4.7A)
 1.10A 2jjpA-2wtzA:
undetectable		 2jjpA-2wtzA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 HIS A 400
ALA A 143
ALA A 147
GLN A 282
GLN A 283
 None
 1.29A 2jjpA-2x0qA:
undetectable		 2jjpA-2x0qA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 HIS A 400
PRO A 184
ALA A 143
ALA A 147
GLN A 283
 None
 1.05A 2jjpA-2x0qA:
undetectable		 2jjpA-2x0qA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5w KINESIN HEAVY CHAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 ALA A 274
LEU A 275
ALA A 276
THR A 332
ILE A 306
 None
 1.11A 2jjpA-2y5wA:
undetectable		 2jjpA-2y5wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 PRO A 925
LEU A 753
ALA A1004
GLN A 847
ILE A 830
 None
 1.29A 2jjpA-2yocA:
undetectable		 2jjpA-2yocA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu CROSSOVER JUNCTION
ENDONUCLEASE EME1
MUS81 PROTEIN

(Danio rerio;
Homo sapiens) 		PF02732
(ERCC4) 		6 ALA B 421
LEU B 359
ALA B 358
THR B 311
PHE B 439
GLN A 445
 None
 1.45A 2jjpA-2ziuB:
undetectable		 2jjpA-2ziuB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
fragi) 		PF13561
(adh_short_C2) 		5 ALA A 235
LEU A 238
ALA A 239
PHE A 134
ILE A 178
 None
 1.28A 2jjpA-2ztuA:
undetectable		 2jjpA-2ztuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 HIS A 653
LEU A 326
ALA A 327
PHE A 646
GLN A 645
 HEM  A 801 (-3.3A)
HEM  A 801 (-4.2A)
HEM  A 801 (-3.9A)
None
None
 1.26A 2jjpA-3ayfA:
1.2		 2jjpA-3ayfA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 MET A 249
ALA A 233
LEU A 234
ALA A 235
ILE A 266
 None
 1.21A 2jjpA-3dipA:
undetectable		 2jjpA-3dipA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		5 PRO A 271
ALA A 246
THR A 208
GLN A 217
ILE A 216
 None
 1.24A 2jjpA-3dmsA:
undetectable		 2jjpA-3dmsA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472

(Listeria
monocytogenes) 		PF04816
(TrmK) 		5 PRO A  40
ALA A 120
LEU A 119
ALA A 117
ILE A  32
 None
 1.11A 2jjpA-3gnlA:
undetectable		 2jjpA-3gnlA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1

(Pseudomonas
aeruginosa) 		PF05567
(Neisseria_PilC) 		5 PRO A 645
ALA A 861
LEU A 849
ALA A 850
MET A1046
 None
 1.28A 2jjpA-3hx6A:
undetectable		 2jjpA-3hx6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 PRO A  44
ALA A 248
LEU A 267
ALA A 268
GLN A  72
 None
 1.22A 2jjpA-3i8bA:
undetectable		 2jjpA-3i8bA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igf ALL4481 PROTEIN

(Nostoc sp. PCC
7120) 		PF02374
(ArsA_ATPase) 		5 PRO A 344
ALA A 208
LEU A 209
THR A 244
ILE A 300
 None
 1.18A 2jjpA-3igfA:
undetectable		 2jjpA-3igfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io1 AMINOBENZOYL-GLUTAMA
TE UTILIZATION
PROTEIN

(Klebsiella
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 164
ALA A 161
PHE A 179
GLN A 180
ILE A 178
 None
 1.30A 2jjpA-3io1A:
undetectable		 2jjpA-3io1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kin KINESIN HEAVY CHAIN

(Rattus
norvegicus) 		PF00225
(Kinesin) 		5 ALA B 268
LEU B 269
ALA B 270
THR B 326
ILE B 300
 None
 1.05A 2jjpA-3kinB:
undetectable		 2jjpA-3kinB:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv8 THYMIDYLATE KINASE

(Vibrio cholerae) 		PF02223
(Thymidylate_kin) 		5 ALA A  89
LEU A  88
ALA A  87
THR A  36
ILE A  32
 None
 1.25A 2jjpA-3lv8A:
undetectable		 2jjpA-3lv8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		5 HIS A  66
ALA A  67
LEU A 102
ALA A 101
GLN A 229
 None
None
None
FMT  A 750 ( 4.0A)
None
 1.28A 2jjpA-3nnmA:
undetectable		 2jjpA-3nnmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 PRO A 231
ALA A 221
LEU A 224
THR A 142
ILE A 261
 None
 1.20A 2jjpA-3oksA:
undetectable		 2jjpA-3oksA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjv CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF16448
(LapD_MoxY_N) 		5 ALA D  46
LEU D  49
ALA D  50
GLN D  88
ILE D  90
 None
 1.19A 2jjpA-3pjvD:
undetectable		 2jjpA-3pjvD:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 ALA A 402
LEU A 403
ALA A 404
THR A 134
ILE A 241
 None
 1.23A 2jjpA-3qfhA:
undetectable		 2jjpA-3qfhA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT

(Mycobacterium
marinum) 		PF00202
(Aminotran_3) 		5 PRO A 230
ALA A 220
LEU A 223
THR A 141
ILE A 260
 None
 1.17A 2jjpA-3r4tA:
undetectable		 2jjpA-3r4tA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 ALA A  30
LEU A  33
ALA A  34
THR A  38
GLN A  61
 None
 0.91A 2jjpA-3rv6A:
undetectable		 2jjpA-3rv6A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 MET A   5
PRO A  23
ALA A  15
PHE A  61
ILE A  62
 None
 1.19A 2jjpA-3s2gA:
undetectable		 2jjpA-3s2gA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		5 ALA A 413
LEU A 414
ALA A 415
GLN A 585
ILE A 481
 None
 1.17A 2jjpA-3tbfA:
undetectable		 2jjpA-3tbfA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0b OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ALA A 369
LEU A 370
ALA A 371
THR A 436
ILE A 339
 None
 1.18A 2jjpA-3u0bA:
undetectable		 2jjpA-3u0bA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ul5 CANECYSTATIN-1

(Saccharum
officinarum) 		PF16845
(SQAPI) 		5 HIS A  58
ALA A  29
LEU A  32
ALA A  33
GLN A  59
 GOL  A 301 (-4.2A)
GOL  A 301 ( 4.0A)
GOL  A 301 (-4.2A)
None
None
 1.27A 2jjpA-3ul5A:
undetectable		 2jjpA-3ul5A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdo MFS TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 PRO A 324
ALA A 383
LEU A 382
ALA A 379
MET A 222
 None
 1.15A 2jjpA-3wdoA:
undetectable		 2jjpA-3wdoA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdq BETA-MANNANASE

(Symbiotic
protist of
Reticulitermes
speratus) 		PF02156
(Glyco_hydro_26) 		5 LEU A 334
THR A 329
PHE A 304
MET A 286
ILE A  48
 None
 1.26A 2jjpA-3wdqA:
undetectable		 2jjpA-3wdqA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpl PUTATIVE MARR-FAMILY
TRANSCRIPTIONAL
REPRESSOR

(Streptomyces
coelicolor) 		PF12802
(MarR_2) 		5 PRO A  55
ALA A  78
LEU A  82
ALA A  80
ILE A 103
 None
 1.17A 2jjpA-3zplA:
undetectable		 2jjpA-3zplA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 5 ALA A 196
LEU A 133
ALA A 135
THR A 230
GLN A 285
 None
 1.14A 2jjpA-4bpsA:
undetectable		 2jjpA-4bpsA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c82 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Plasmodium
falciparum) 		PF02542
(YgbB) 		5 PRO A 184
ALA A 155
LEU A 158
THR A 199
ILE A 193
 None
 1.03A 2jjpA-4c82A:
undetectable		 2jjpA-4c82A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A  87
LEU A  84
ALA A  83
GLN A  44
ILE A  70
 None
 1.01A 2jjpA-4cokA:
undetectable		 2jjpA-4cokA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		5 PRO A 320
ALA A 256
LEU A 259
ALA A 260
ILE A 163
 None
 1.20A 2jjpA-4czeA:
undetectable		 2jjpA-4czeA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 PRO A 144
ALA A 281
LEU A 283
ALA A  63
ILE A 141
 HEM  A1374 (-4.1A)
None
None
None
None
 1.18A 2jjpA-4czpA:
undetectable		 2jjpA-4czpA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd6 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
2

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		5 LEU A 214
ALA A 171
THR A 169
GLN A 124
ILE A 119
 None
 1.29A 2jjpA-4fd6A:
undetectable		 2jjpA-4fd6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		5 PRO A 229
ALA A 219
LEU A 222
THR A 145
ILE A 259
 None
 1.23A 2jjpA-4ffcA:
undetectable		 2jjpA-4ffcA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 MET A 109
PRO A 504
ALA A 176
ALA A 172
GLN A 328
 PXM  A 609 ( 4.8A)
FAD  A 601 (-4.3A)
None
None
PXM  A 609 ( 3.9A)
 1.29A 2jjpA-4ha6A:
undetectable		 2jjpA-4ha6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 ALA A 710
LEU A 714
ALA A 712
THR A 755
GLN A 727
 None
 1.24A 2jjpA-4i2wA:
undetectable		 2jjpA-4i2wA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE

(Toxoplasma
gondii) 		PF00316
(FBPase) 		5 ALA A 277
LEU A 280
ALA A 279
THR A 289
GLN A 253
 None
 1.03A 2jjpA-4ir8A:
undetectable		 2jjpA-4ir8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj9 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Bordetella
bronchiseptica) 		PF02962
(CHMI) 		5 ALA A  26
LEU A  25
ALA A  28
THR A  98
ILE A 122
 None
 1.29A 2jjpA-4jj9A:
undetectable		 2jjpA-4jj9A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k29 ENOYL-COA
HYDRATASE/ISOMERASE

(Xanthobacter
autotrophicus) 		PF00378
(ECH_1) 		5 ALA A 114
LEU A 117
ALA A 118
THR A 124
ILE A  53
 None
 1.10A 2jjpA-4k29A:
undetectable		 2jjpA-4k29A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2

(Homo sapiens) 		no annotation 5 PRO A 119
ALA A 300
LEU A 299
THR A 251
ILE A 122
 None
 1.22A 2jjpA-4nzmA:
undetectable		 2jjpA-4nzmA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0r CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Homo sapiens) 		PF02732
(ERCC4) 		5 ALA B 421
LEU B 359
ALA B 358
THR B 311
PHE B 439
 None
 1.23A 2jjpA-4p0rB:
undetectable		 2jjpA-4p0rB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 ALA A 149
LEU A 150
THR A 274
PHE A  98
ILE A  54
 None
 1.27A 2jjpA-4pdhA:
undetectable		 2jjpA-4pdhA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 MET B 974
PRO B 902
LEU B 939
ALA B 937
ILE B 989
 None
 1.24A 2jjpA-4qiwB:
undetectable		 2jjpA-4qiwB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsw HOPA1

(Pseudomonas
syringae) 		no annotation 5 PRO A 310
ALA A 247
LEU A 251
ALA A 249
ILE A 277
 None
 1.25A 2jjpA-4rswA:
undetectable		 2jjpA-4rswA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PRO A  26
LEU A 145
ALA A 146
GLN A 126
ILE A  90
 None
 1.24A 2jjpA-4w6zA:
undetectable		 2jjpA-4w6zA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		5 MET A 228
ALA A  56
ALA A  54
THR A  25
ILE A  74
 None
 1.29A 2jjpA-4wj3A:
undetectable		 2jjpA-4wj3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl1 DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		5 ALA B  45
LEU B 139
THR B  56
GLN B 160
ILE B 119
 None
 1.23A 2jjpA-4xl1B:
undetectable		 2jjpA-4xl1B:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xlw DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		5 ALA B  45
LEU B 139
THR B  56
GLN B 160
ILE B 119
 None
 1.27A 2jjpA-4xlwB:
undetectable		 2jjpA-4xlwB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxt FUSION OF PREDICTED
ZN-DEPENDENT
AMIDASE/PEPTIDASE
(CELL WALL
HYDROLASE/DD-CARBOXY
PEPTIDASE FAMILY)
AND UNCHARACTERIZED
DOMAIN OF ERFK
FAMILY
PEPTODOGLYCAN-BINDIN
G DOMAIN

(Clostridium
acetobutylicum) 		PF01471
(PG_binding_1)
PF03734
(YkuD) 		5 ALA A 146
LEU A 149
ALA A 150
THR A 155
ILE A 280
 EDO  A 301 ( 4.7A)
EDO  A 301 ( 4.2A)
None
None
None
 0.95A 2jjpA-4xxtA:
undetectable		 2jjpA-4xxtA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1m MU-TYPE OPIOID
RECEPTOR

(Mus musculus) 		PF00001
(7tm_1) 		5 ALA A 113
LEU A 116
ALA A 117
THR A 120
ILE A 142
 None
 1.26A 2jjpA-5c1mA:
1.8		 2jjpA-5c1mA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Colwellia
psychrerythraea) 		PF01791
(DeoC) 		5 ALA A  11
LEU A  12
ALA A   8
THR A 244
ILE A 239
 None
 1.17A 2jjpA-5c5yA:
undetectable		 2jjpA-5c5yA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 PRO A 792
ALA A 678
ALA A 680
GLN A 750
GLN A 767
 None
 1.03A 2jjpA-5f7uA:
undetectable		 2jjpA-5f7uA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joq LMO2184 PROTEIN

(Listeria
monocytogenes) 		PF01497
(Peripla_BP_2) 		5 ALA A  39
LEU A  95
THR A  97
PHE A 120
GLN A 127
 None
None
CL  A 302 (-4.1A)
None
None
 1.25A 2jjpA-5joqA:
undetectable		 2jjpA-5joqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		5 MET A 499
ALA A 315
LEU A 318
ALA A 319
THR A 365
 None
 1.26A 2jjpA-5l25A:
undetectable		 2jjpA-5l25A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvx DELTA-LIKE PROTEIN 4

(Homo sapiens) 		PF00008
(EGF)
PF01414
(DSL)
PF07657
(MNNL) 		5 ALA A  45
LEU A 139
THR A  56
GLN A 160
ILE A 119
 None
 1.20A 2jjpA-5mvxA:
undetectable		 2jjpA-5mvxA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 5 PRO E 302
LEU E 249
ALA E 248
THR E 251
ILE E 293
 None
 1.28A 2jjpA-5n6yE:
undetectable		 2jjpA-5n6yE:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nus P34

(Chaetomium
thermophilum) 		no annotation 5 MET A 127
PRO A  33
LEU A 148
ALA A 149
THR A  26
 None
 1.23A 2jjpA-5nusA:
undetectable		 2jjpA-5nusA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 5 HIS A 676
MET A 705
ALA A 679
LEU A 683
ALA A 681
 None
 1.09A 2jjpA-5ot1A:
undetectable		 2jjpA-5ot1A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26

(Saccharomyces
cerevisiae) 		no annotation 5 PRO M 754
ALA M 742
ALA M 670
MET M 583
ILE M 747
 None
 1.09A 2jjpA-5vvrM:
undetectable		 2jjpA-5vvrM:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 ALA A1268
LEU A1267
ALA A1266
THR A1265
GLN A1294
 None
 1.21A 2jjpA-5wblA:
undetectable		 2jjpA-5wblA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpi HSVA

(Erwinia
amylovora) 		no annotation 5 PRO A  17
ALA A 352
ALA A 119
PHE A 149
ILE A 152
 PRO  A  17 ( 1.1A)
ALA  A 352 ( 0.0A)
ALA  A 119 ( 0.0A)
PHE  A 149 ( 1.3A)
ILE  A 152 ( 0.6A)
 1.30A 2jjpA-5wpiA:
undetectable		 2jjpA-5wpiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 5 PRO A 359
ALA A 391
LEU A 394
ALA A 395
PHE A 335
 None
 1.21A 2jjpA-5xmrA:
undetectable		 2jjpA-5xmrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 5 PRO A  29
LEU A 148
ALA A 149
GLN A 129
ILE A  93
 None
 1.21A 2jjpA-5yatA:
undetectable		 2jjpA-5yatA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc2 -

(-) 		no annotation 5 LEU B 224
ALA B 221
THR B 218
GLN B 239
ILE B 249
 None
 1.26A 2jjpA-5zc2B:
undetectable		 2jjpA-5zc2B:
undetectable