SIMILAR PATTERNS OF AMINO ACIDS FOR 2JIH_B_097B1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 800 (-3.2A)
ZN  A 800 ( 4.7A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.3A)
 0.36A 2jihB-1budA:
25.0		 2jihB-1budA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb6 NEUTRAL PROTEASE II

(Aspergillus
oryzae) 		PF02102
(Peptidase_M35) 		5 LEU A  90
THR A 125
HIS A 128
GLU A 129
HIS A 132
 None
None
ZN  A 178 (-3.3A)
ZN  A 178 ( 4.0A)
ZN  A 178 (-3.3A)
 0.47A 2jihB-1eb6A:
4.6		 2jihB-1eb6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)

(Sus scrofa) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 HTA  A 900 (-3.6A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.41A 2jihB-1fblA:
9.8		 2jihB-1fblA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE

(Grifola
frondosa) 		PF14521
(Aspzincin_M35) 		4 THR A 114
HIS A 117
GLU A 118
HIS A 121
 None
ZN  A 200 (-3.3A)
ZN  A 200 ( 4.2A)
ZN  A 200 (-3.2A)
 0.36A 2jihB-1ge7A:
2.3		 2jihB-1ge7A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 THR P 166
HIS P 169
GLU P 170
HIS P 173
HIS P 179
 None
ZN  P 600 (-3.4A)
ZN  P 600 ( 4.0A)
ZN  P 600 (-3.4A)
ZN  P 600 (-3.4A)
 0.33A 2jihB-1h71P:
3.0		 2jihB-1h71P:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfs STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.40A 2jihB-1hfsA:
10.6		 2jihB-1hfsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		6 LEU A 108
HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 170
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
 0.58A 2jihB-1htdA:
25.3		 2jihB-1htdA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		6 LEU A 108
THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
 0.45A 2jihB-1htdA:
25.3		 2jihB-1htdA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		5 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
 1.29A 2jihB-1htdA:
25.3		 2jihB-1htdA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv5 STROMELYSIN 3

(Mus musculus) 		PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.44A 2jihB-1hv5A:
9.9		 2jihB-1hv5A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iab ASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		5 THR A  89
HIS A  92
GLU A  93
HIS A  96
HIS A 102
 None
CO  A 999 (-3.2A)
CO  A 999 ( 4.3A)
CO  A 999 (-3.3A)
CO  A 999 (-3.1A)
 0.25A 2jihB-1iabA:
7.6		 2jihB-1iabA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.27A 2jihB-1kugA:
26.8		 2jihB-1kugA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.36A 2jihB-1l6jA:
9.3		 2jihB-1l6jA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 170
 ZN  A 400 (-3.2A)
ZN  A 400 ( 4.4A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
None
 0.45A 2jihB-1nd1A:
25.3		 2jihB-1nd1A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		5 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 None
None
ZN  A 400 (-3.2A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
 1.28A 2jihB-1nd1A:
25.3		 2jihB-1nd1A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 400 (-3.2A)
ZN  A 400 ( 4.4A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
 0.33A 2jihB-1nd1A:
25.3		 2jihB-1nd1A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qib 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 None
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
 0.33A 2jihB-1qibA:
10.1		 2jihB-1qibA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 168
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
None
 0.43A 2jihB-1quaA:
25.8		 2jihB-1quaA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A 168
THR A 139
HIS A 142
HIS A 146
HIS A 152
 None
None
ZN  A 999 (-3.2A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
 1.28A 2jihB-1quaA:
25.8		 2jihB-1quaA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
 0.36A 2jihB-1quaA:
25.8		 2jihB-1quaA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		5 THR A 342
HIS A 345
GLU A 346
HIS A 349
HIS A 355
 097  A 518 (-3.5A)
ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
 0.29A 2jihB-1r55A:
25.5		 2jihB-1r55A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.28A 2jihB-1rm8A:
9.8		 2jihB-1rm8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.38A 2jihB-1slmA:
10.1		 2jihB-1slmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su3 INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 LEU A 181
HIS A 218
HIS A 222
HIS A 228
 None
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.33A 2jihB-1su3A:
8.9		 2jihB-1su3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 999 (-3.5A)
ZN  A 999 ( 4.2A)
ZN  A 999 (-3.5A)
ZN  A 999 (-3.4A)
 0.29A 2jihB-1wniA:
26.3		 2jihB-1wniA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 THR 1 466
HIS 1 469
GLU 1 470
HIS 1 473
 GLY  1 703 ( 4.6A)
ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
 0.24A 2jihB-1y791:
undetectable		 2jihB-1y791:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 (-3.3A)
ZN  A 999 ( 4.9A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
 0.20A 2jihB-1yp1A:
25.8		 2jihB-1yp1A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw1 CATROCOLLASTATIN

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.18A 2jihB-2dw1A:
26.5		 2jihB-2dw1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A 111
HIS A 145
GLU A 146
HIS A 149
HIS A 155
 GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.29A 2jihB-2e3xA:
24.7		 2jihB-2e3xA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A 111
HIS A 145
HIS A 149
HIS A 155
LEU A 173
 GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.3A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
GM6  A 700 ( 3.9A)
 0.75A 2jihB-2e3xA:
24.7		 2jihB-2e3xA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 HIS A 335
GLU A 336
HIS A 339
HIS A 345
LEU A 363
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
None
 0.72A 2jihB-2erqA:
26.3		 2jihB-2erqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens) 		PF13688
(Reprolysin_5) 		5 LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
 541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
 0.23A 2jihB-2fv5A:
20.6		 2jihB-2fv5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		4 THR A 470
HIS A 473
GLU A 474
HIS A 477
 None
ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
 0.30A 2jihB-2o36A:
2.3		 2jihB-2o36A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		4 THR A 471
HIS A 474
GLU A 475
HIS A 478
 None
ZN  A 679 (-3.4A)
ZN  A 679 ( 4.5A)
ZN  A 679 (-3.3A)
 0.38A 2jihB-2o3eA:
undetectable		 2jihB-2o3eA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy4 NEUTROPHIL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 160
HIS A 197
GLU A 198
HIS A 201
HIS A 207
 None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
 0.33A 2jihB-2oy4A:
10.3		 2jihB-2oy4A:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		6 LEU A 379
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
 BAT  A 559 (-4.0A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 0.57A 2jihB-2rjqA:
40.2		 2jihB-2rjqA:
48.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		6 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.26A 2jihB-2rjqA:
40.2		 2jihB-2rjqA:
48.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7m ARCHAEMETZINCIN

(Methanopyrus
kandleri) 		PF07998
(Peptidase_M54) 		4 HIS A 125
GLU A 126
HIS A 129
HIS A 135
 ZN  A1174 (-3.2A)
ZN  A1174 ( 4.2A)
ZN  A1174 (-3.2A)
ZN  A1174 (-3.2A)
 0.28A 2jihB-2x7mA:
13.9		 2jihB-2x7mA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 THR A 358
HIS A 361
GLU A 362
HIS A 365
 3ES  A1611 (-3.6A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
 0.23A 2jihB-2xydA:
undetectable		 2jihB-2xydA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.21A 2jihB-2y6cA:
9.3		 2jihB-2y6cA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 THR A 350
HIS A 353
GLU A 354
HIS A 357
 BES  A1950 ( 4.3A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
 0.23A 2jihB-2yd0A:
3.8		 2jihB-2yd0A:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		4 THR A 358
HIS A 361
HIS A 365
HIS A 371
 None
ZN  A   1 (-3.0A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.2A)
 0.25A 2jihB-3b2zA:
41.2		 2jihB-3b2zA:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		7 ASP A 377
LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
 None
294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
 0.44A 2jihB-3b8zA:
35.6		 2jihB-3b8zA:
58.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		5 THR A 407
GLU A 411
HIS A 414
HIS A 420
LEU A 443
 294  A 801 ( 3.8A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
294  A 801 (-4.1A)
 0.94A 2jihB-3b8zA:
35.6		 2jihB-3b8zA:
58.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba0 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		6 LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
None
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
 0.79A 2jihB-3ba0A:
9.7		 2jihB-3ba0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 503 ( 3.3A)
TRP  A 505 (-2.4A)
ZN  A 503 ( 3.3A)
ZN  A 503 ( 3.3A)
 0.26A 2jihB-3dslA:
25.6		 2jihB-3dslA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edi TOLLOID-LIKE PROTEIN
1

(Homo sapiens) 		PF01400
(Astacin) 		4 HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
 0.27A 2jihB-3ediA:
6.4		 2jihB-3ediA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 HIS A 140
GLU A 141
HIS A 144
HIS A 150
LEU A 168
 ZN  A 302 (-3.3A)
ZN  A 302 ( 4.6A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
None
 0.51A 2jihB-3gboA:
25.5		 2jihB-3gboA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 LEU A 168
THR A 137
HIS A 140
HIS A 144
HIS A 150
 None
None
ZN  A 302 (-3.3A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
 1.27A 2jihB-3gboA:
25.5		 2jihB-3gboA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 THR A 137
HIS A 140
GLU A 141
HIS A 144
HIS A 150
 None
ZN  A 302 (-3.3A)
ZN  A 302 ( 4.6A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
 0.28A 2jihB-3gboA:
25.5		 2jihB-3gboA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdb AAHIV

(Deinagkistrodon
acutus) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.23A 2jihB-3hdbA:
26.2		 2jihB-3hdbA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 THR A 338
HIS A 341
GLU A 342
HIS A 345
HIS A 351
 None
ZN  A 704 (-3.1A)
ZN  A 704 ( 4.5A)
ZN  A 704 (-3.3A)
ZN  A 704 (-3.2A)
 0.36A 2jihB-3k7nA:
26.2		 2jihB-3k7nA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 THR A 371
HIS A 374
GLU A 375
HIS A 378
 None
 0.36A 2jihB-3kbhA:
undetectable		 2jihB-3kbhA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmc PEPTIDASE,
ZINC-DEPENDENT

(Methanocorpusculum
labreanum) 		PF07998
(Peptidase_M54) 		4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.19A 2jihB-3lmcA:
12.7		 2jihB-3lmcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq0 PROASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		4 THR A  89
HIS A  92
HIS A  96
HIS A 102
 None
ZN  A 999 (-3.3A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.3A)
 0.20A 2jihB-3lq0A:
6.9		 2jihB-3lq0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqb LOC792177 PROTEIN

(Danio rerio) 		PF01400
(Astacin) 		4 HIS A  99
GLU A 100
HIS A 103
HIS A 109
 ZN  A 201 ( 3.2A)
SO4  A 200 (-3.0A)
ZN  A 201 ( 3.3A)
ZN  A 201 ( 3.2A)
 0.16A 2jihB-3lqbA:
8.0		 2jihB-3lqbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		6 LEU A 188
THR A 225
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.43A 2jihB-3lunA:
14.1		 2jihB-3lunA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2x COLLAGENASE 3

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A1185
HIS A1222
GLU A1223
HIS A1226
HIS A1232
 3O2  A1801 (-4.0A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
 0.33A 2jihB-3o2xA:
10.4		 2jihB-3o2xA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		5 LEU A 314
HIS A 348
GLU A 349
HIS A 352
HIS A 358
 None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.9A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 3.2A)
 0.28A 2jihB-3p24A:
15.5		 2jihB-3p24A:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		7 ASP A 116
LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
 None
QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
 0.36A 2jihB-3q2hA:
46.3		 2jihB-3q2hA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		7 LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
LEU A 182
 QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
QHF  A   1 (-4.7A)
 0.51A 2jihB-3q2hA:
46.3		 2jihB-3q2hA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shi INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.33A 2jihB-3shiA:
9.3		 2jihB-3shiA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u04 PEPTIDE DEFORMYLASE
1

(Ehrlichia
chaffeensis) 		PF01327
(Pep_deformylase) 		4 LEU A  45
HIS A 153
GLU A 154
HIS A 157
 BB2  A 210 (-4.1A)
ZN  A 200 ( 3.3A)
BB2  A 210 (-2.7A)
ZN  A 200 ( 3.3A)
 0.23A 2jihB-3u04A:
undetectable		 2jihB-3u04A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v96 STROMELYSIN-2

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.45A 2jihB-3v96B:
10.6		 2jihB-3v96B:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		5 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 None
ZN  A 500 (-3.2A)
ZN  A 500 ( 4.2A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.2A)
 0.31A 2jihB-3vi1A:
7.4		 2jihB-3vi1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtg HIGH CHORIOLYTIC
ENZYME 1

(Oryzias latipes) 		PF01400
(Astacin) 		4 HIS A  99
GLU A 100
HIS A 103
HIS A 109
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.23A 2jihB-3vtgA:
7.9		 2jihB-3vtgA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3w ARCHAEMETZINCIN

(Archaeoglobus
fulgidus) 		PF07998
(Peptidase_M54) 		4 HIS A 117
GLU A 118
HIS A 121
HIS A 127
 ZN  A1159 ( 3.2A)
FLC  A1161 (-2.9A)
ZN  A1159 ( 3.3A)
ZN  A1159 ( 3.2A)
 0.31A 2jihB-4a3wA:
11.6		 2jihB-4a3wA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 170
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
FLX  A 400 (-4.0A)
 0.53A 2jihB-4aigA:
25.5		 2jihB-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 FLX  A 400 (-4.0A)
FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 1.11A 2jihB-4aigA:
25.5		 2jihB-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.34A 2jihB-4aigA:
25.5		 2jihB-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auo INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 LEU A 162
HIS A 199
HIS A 203
HIS A 209
 None
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.29A 2jihB-4auoA:
9.9		 2jihB-4auoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF01421
(Reprolysin) 		5 THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
 BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.38A 2jihB-4dd8A:
26.2		 2jihB-4dd8A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 ASP A  89
THR A 223
GLU A 222
HIS A 219
HIS A 192
 None
None
NOS  A 501 (-3.0A)
NOS  A 501 (-3.5A)
NOS  A 501 (-4.0A)
 1.04A 2jihB-4f0sA:
undetectable		 2jihB-4f0sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvl COLLAGENASE 3

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 LEU A 185
HIS A 222
HIS A 226
HIS A 232
 None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.39A 2jihB-4fvlA:
9.8		 2jihB-4fvlA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr8 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		6 LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.49A 2jihB-4gr8A:
10.8		 2jihB-4gr8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		5 THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
 None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.39A 2jihB-4gwnA:
6.6		 2jihB-4gwnA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4in9 KARILYSIN PROTEASE

(Tannerella
forsythia) 		PF00413
(Peptidase_M10) 		5 LEU A 115
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.58A 2jihB-4in9A:
10.1		 2jihB-4in9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 THR A 474
HIS A 477
GLU A 478
HIS A 481
 CIT  A 702 ( 4.0A)
ZN  A 701 ( 3.2A)
CIT  A 702 (-2.4A)
ZN  A 701 ( 3.4A)
 0.33A 2jihB-4iuwA:
undetectable		 2jihB-4iuwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
 0.26A 2jihB-4j4mA:
26.5		 2jihB-4j4mA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 THR A 568
HIS A 571
GLU A 572
HIS A 575
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
 0.24A 2jihB-4ka8A:
3.0		 2jihB-4ka8A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXA

(Escherichia
coli) 		PF16313
(DUF4953) 		6 LEU A 122
THR A 176
HIS A 179
GLU A 180
HIS A 183
HIS A 189
 None
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.52A 2jihB-4l63A:
6.8		 2jihB-4l63A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on1 PUTATIVE
METALLOPROTEASE II

(Bacteroides
fragilis) 		PF00413
(Peptidase_M10)
PF16376
(fragilysinNterm) 		4 THR A 348
HIS A 351
HIS A 355
HIS A 361
 None
ZN  A 400 (-3.2A)
ZN  A 400 (-3.2A)
ZN  A 400 (-3.1A)
 0.11A 2jihB-4on1A:
14.8		 2jihB-4on1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 302 (-3.2A)
ZN  A 302 ( 4.7A)
ZN  A 302 (-3.1A)
ZN  A 302 (-3.1A)
 0.30A 2jihB-4q1lA:
25.9		 2jihB-4q1lA:
26.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		7 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.51A 2jihB-4wk7A:
35.9		 2jihB-4wk7A:
53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 THR A 363
HIS A 366
GLU A 367
HIS A 370
 None
ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
 0.25A 2jihB-4wz9A:
undetectable		 2jihB-4wz9A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.35A 2jihB-4xctA:
11.3		 2jihB-4xctA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 THR A 364
HIS A 367
GLU A 368
HIS A 371
 None
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
 0.25A 2jihB-5a2rA:
undetectable		 2jihB-5a2rA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvi SLOR

(Streptococcus
mutans) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		5 LEU A 101
HIS A  76
GLU A 102
HIS A  95
LEU A  83
 None
ZN  A 303 (-3.2A)
ZN  A 301 (-3.0A)
ZN  A 303 (-3.1A)
None
 1.31A 2jihB-5cviA:
undetectable		 2jihB-5cviA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 301 ( 3.4A)
ZN  A 301 ( 4.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.1A)
 0.33A 2jihB-5czwA:
2.9		 2jihB-5czwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 THR  A 173 ( 0.8A)
HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.37A 2jihB-5d7wA:
6.8		 2jihB-5d7wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0u MATRIX
METALLOPROTEINASE-14

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.38A 2jihB-5h0uA:
7.4		 2jihB-5h0uA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C

(Schizosaccharomyces
pombe) 		PF08325
(WLM) 		6 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.51A 2jihB-5jigA:
4.3		 2jihB-5jigA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		4 THR A 460
HIS A 463
GLU A 464
HIS A 467
 None
ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
 0.23A 2jihB-5l44A:
undetectable		 2jihB-5l44A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.34A 2jihB-5th6A:
9.3		 2jihB-5th6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbn WSS1P

(Saccharomyces
cerevisiae) 		no annotation 6 LEU A  80
THR A 112
HIS A 115
GLU A 116
HIS A 119
HIS A 125
 None
None
ZN  A 201 (-3.2A)
ZN  A 201 ( 4.7A)
ZN  A 201 (-3.3A)
ZN  A 201 (-3.2A)
 0.32A 2jihB-5xbnA:
4.1		 2jihB-5xbnA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 569
THR A 537
HIS A 540
GLU A 541
HIS A 544
 None
None
ZN  A 802 (-3.4A)
None
ZN  A 802 (-3.3A)
 0.47A 2jihB-6az0A:
undetectable		 2jihB-6az0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 5 ASP A 325
HIS A 383
GLU A 384
HIS A 387
HIS A 393
 None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
 0.71A 2jihB-6bdzA:
20.2		 2jihB-6bdzA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 5 LEU A 328
HIS A 383
GLU A 384
HIS A 387
HIS A 393
 None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
 0.65A 2jihB-6bdzA:
20.2		 2jihB-6bdzA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 5 LEU A 328
THR A 380
HIS A 383
HIS A 387
HIS A 393
 None
None
ZN  A 705 (-3.3A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
 0.62A 2jihB-6bdzA:
20.2		 2jihB-6bdzA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btp -

(-) 		no annotation 4 HIS A  93
GLU A  94
HIS A  97
HIS A 103
 ZN  A 302 ( 3.3A)
E8J  A 304 (-2.6A)
ZN  A 302 ( 3.4A)
ZN  A 302 ( 3.3A)
 0.21A 2jihB-6btpA:
6.6		 2jihB-6btpA:
undetectable