SIMILAR PATTERNS OF AMINO ACIDS FOR 2JIH_A_097A1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 800 (-3.2A)
ZN  A 800 ( 4.7A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.3A)
 0.36A 2jihA-1budA:
25.0		 2jihA-1budA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		5 LEU A 286
HIS A 287
GLU A 278
HIS A 275
HIS A 271
 None
ZN  A 402 (-3.3A)
NAD  A 400 ( 4.8A)
CRB  A 401 (-4.2A)
ZN  A 402 ( 3.1A)
 1.47A 2jihA-1dqsA:
undetectable		 2jihA-1dqsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb6 NEUTRAL PROTEASE II

(Aspergillus
oryzae) 		PF02102
(Peptidase_M35) 		5 LEU A  90
THR A 125
HIS A 128
GLU A 129
HIS A 132
 None
None
ZN  A 178 (-3.3A)
ZN  A 178 ( 4.0A)
ZN  A 178 (-3.3A)
 0.47A 2jihA-1eb6A:
4.9		 2jihA-1eb6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)

(Sus scrofa) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 HTA  A 900 (-3.6A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.39A 2jihA-1fblA:
8.4		 2jihA-1fblA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 THR P 166
HIS P 169
GLU P 170
HIS P 173
HIS P 179
 None
ZN  P 600 (-3.4A)
ZN  P 600 ( 4.0A)
ZN  P 600 (-3.4A)
ZN  P 600 (-3.4A)
 0.35A 2jihA-1h71P:
7.0		 2jihA-1h71P:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfs STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.40A 2jihA-1hfsA:
10.4		 2jihA-1hfsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		6 LEU A 108
THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
 0.46A 2jihA-1htdA:
25.4		 2jihA-1htdA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		5 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
 1.39A 2jihA-1htdA:
25.4		 2jihA-1htdA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv5 STROMELYSIN 3

(Mus musculus) 		PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.40A 2jihA-1hv5A:
9.8		 2jihA-1hv5A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iab ASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		5 THR A  89
HIS A  92
GLU A  93
HIS A  96
HIS A 102
 None
CO  A 999 (-3.2A)
CO  A 999 ( 4.3A)
CO  A 999 (-3.3A)
CO  A 999 (-3.1A)
 0.29A 2jihA-1iabA:
6.5		 2jihA-1iabA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 5 ASP A 134
HIS A  66
HIS A 112
HIS A  68
LEU A 172
 None
CU  A 401 ( 3.3A)
CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
None
 1.45A 2jihA-1juhA:
undetectable		 2jihA-1juhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.23A 2jihA-1kugA:
26.7		 2jihA-1kugA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		6 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
MET A 422
 None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
None
 0.47A 2jihA-1l6jA:
9.2		 2jihA-1l6jA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		5 LEU A 224
HIS A 264
GLU A 265
HIS A 268
HIS A 334
 None
ZN  A 578 ( 3.5A)
ZN  A 578 ( 4.1A)
ZN  A 578 ( 3.4A)
ZN  A 578 ( 3.4A)
 0.93A 2jihA-1lmlA:
4.5		 2jihA-1lmlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		5 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 None
None
ZN  A 400 (-3.2A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
 1.40A 2jihA-1nd1A:
25.3		 2jihA-1nd1A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 400 (-3.2A)
ZN  A 400 ( 4.4A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
 0.33A 2jihA-1nd1A:
25.3		 2jihA-1nd1A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
HIS A 146
HIS A 152
LEU A 170
 None
ZN  A 400 (-3.2A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
None
 0.82A 2jihA-1nd1A:
25.3		 2jihA-1nd1A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qib 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 None
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
 0.29A 2jihA-1qibA:
9.9		 2jihA-1qibA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A 168
THR A 139
HIS A 142
HIS A 146
HIS A 152
 None
None
ZN  A 999 (-3.2A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
 1.38A 2jihA-1quaA:
25.8		 2jihA-1quaA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		6 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 168
 None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
None
 0.79A 2jihA-1quaA:
25.8		 2jihA-1quaA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		5 THR A 342
HIS A 345
GLU A 346
HIS A 349
HIS A 355
 097  A 518 (-3.5A)
ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
 0.28A 2jihA-1r55A:
25.6		 2jihA-1r55A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.30A 2jihA-1rm8A:
10.3		 2jihA-1rm8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.40A 2jihA-1slmA:
9.7		 2jihA-1slmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 999 (-3.5A)
ZN  A 999 ( 4.2A)
ZN  A 999 (-3.5A)
ZN  A 999 (-3.4A)
 0.26A 2jihA-1wniA:
26.3		 2jihA-1wniA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		5 LEU A 189
HIS A 215
HIS A 194
HIS A 216
LEU A 222
 None
None
CU  A 401 ( 3.2A)
CU  A 401 ( 3.4A)
None
 1.28A 2jihA-1wx4A:
undetectable		 2jihA-1wx4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y13 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
falciparum) 		PF01242
(PTPS) 		5 THR A  39
HIS A  41
GLU A  38
HIS A  29
HIS A  43
 None
ZN  A 174 ( 3.3A)
BIO  A 175 (-2.6A)
ZN  A 174 ( 3.5A)
ZN  A 174 ( 3.4A)
 1.23A 2jihA-1y13A:
undetectable		 2jihA-1y13A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0s 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
vivax) 		PF01242
(PTPS) 		5 THR A  46
HIS A  48
GLU A  45
HIS A  36
HIS A  50
 None
ZN  A 281 (-3.3A)
BIO  A 282 (-3.1A)
ZN  A 281 ( 3.5A)
ZN  A 281 (-3.3A)
 1.21A 2jihA-2a0sA:
undetectable		 2jihA-2a0sA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A 111
HIS A 145
GLU A 146
HIS A 149
HIS A 155
 GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.33A 2jihA-2e3xA:
24.8		 2jihA-2e3xA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejq HYPOTHETICAL PROTEIN
TTHA0227

(Thermus
thermophilus) 		PF06262
(Zincin_1) 		5 LEU A  46
THR A  92
HIS A  95
GLU A  96
HIS A  99
 None
 0.56A 2jihA-2ejqA:
2.9		 2jihA-2ejqA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 HIS A 335
GLU A 336
HIS A 339
HIS A 345
LEU A 363
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
None
 0.75A 2jihA-2erqA:
26.6		 2jihA-2erqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE

(Lactobacillus
plantarum) 		PF04909
(Amidohydro_2) 		5 ASP A  79
LEU A  54
THR A   8
HIS A   9
HIS A 154
 None
None
None
MN  A 402 (-3.5A)
MN  A 402 (-3.3A)
 1.37A 2jihA-2f6kA:
undetectable		 2jihA-2f6kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens) 		PF13688
(Reprolysin_5) 		5 LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
 541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
 0.29A 2jihA-2fv5A:
20.4		 2jihA-2fv5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		5 THR A 212
HIS A 238
HIS A  97
HIS A  99
LEU A 175
 None
ZN  A 500 (-3.2A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.2A)
None
 1.30A 2jihA-2imrA:
undetectable		 2jihA-2imrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsd MATRIX
METALLOPROTEINASE-20

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 189
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 NGH  A 277 (-4.1A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
 0.70A 2jihA-2jsdA:
9.9		 2jihA-2jsdA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy4 NEUTROPHIL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 160
HIS A 197
GLU A 198
HIS A 201
HIS A 207
 None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
 0.30A 2jihA-2oy4A:
10.2		 2jihA-2oy4A:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		6 ASP A 377
LEU A 379
THR A 407
GLU A 411
HIS A 414
LEU A 443
 BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 1.01A 2jihA-2rjqA:
40.4		 2jihA-2rjqA:
48.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		7 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 0.75A 2jihA-2rjqA:
40.4		 2jihA-2rjqA:
48.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.46A 2jihA-2y6cA:
9.1		 2jihA-2y6cA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		5 LEU A 330
THR A 358
HIS A 361
HIS A 365
HIS A 371
 None
None
ZN  A   1 (-3.0A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.2A)
 0.48A 2jihA-3b2zA:
41.1		 2jihA-3b2zA:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		7 ASP A 377
LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
 None
294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
 0.34A 2jihA-3b8zA:
35.5		 2jihA-3b8zA:
58.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		7 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
 294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
294  A 801 (-4.1A)
 0.64A 2jihA-3b8zA:
35.5		 2jihA-3b8zA:
58.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba0 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		6 LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
None
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
 0.79A 2jihA-3ba0A:
9.6		 2jihA-3ba0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A  18
GLU A  23
HIS A 288
HIS A  53
LEU A  47
 None
 1.42A 2jihA-3docA:
undetectable		 2jihA-3docA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		5 ASP A  74
THR A 105
HIS A 104
GLU A  68
HIS A 205
 None
None
MN3  A 316 (-3.3A)
MN3  A 316 ( 2.4A)
FE  A 317 (-3.4A)
 1.49A 2jihA-3ee4A:
undetectable		 2jihA-3ee4A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 HIS A 140
GLU A 141
HIS A 144
HIS A 150
LEU A 168
 ZN  A 302 (-3.3A)
ZN  A 302 ( 4.6A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
None
 0.79A 2jihA-3gboA:
25.7		 2jihA-3gboA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 LEU A 168
THR A 137
HIS A 140
HIS A 144
HIS A 150
 None
None
ZN  A 302 (-3.3A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
 1.38A 2jihA-3gboA:
25.7		 2jihA-3gboA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 THR A 137
HIS A 140
GLU A 141
HIS A 144
HIS A 150
 None
ZN  A 302 (-3.3A)
ZN  A 302 ( 4.6A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
 0.26A 2jihA-3gboA:
25.7		 2jihA-3gboA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 116
LEU A 307
HIS A 309
GLU A 304
LEU A 340
 None
 1.49A 2jihA-3i6eA:
undetectable		 2jihA-3i6eA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 THR A 338
HIS A 341
GLU A 342
HIS A 345
HIS A 351
 None
ZN  A 704 (-3.1A)
ZN  A 704 ( 4.5A)
ZN  A 704 (-3.3A)
ZN  A 704 (-3.2A)
 0.38A 2jihA-3k7nA:
26.3		 2jihA-3k7nA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmc PEPTIDASE,
ZINC-DEPENDENT

(Methanocorpusculum
labreanum) 		PF07998
(Peptidase_M54) 		5 HIS A 149
GLU A 150
HIS A 153
HIS A 159
LEU A 176
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
None
 0.70A 2jihA-3lmcA:
12.5		 2jihA-3lmcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		5 ASP A 186
LEU A 188
HIS A 228
GLU A 229
HIS A 232
 None
None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
 1.30A 2jihA-3lunA:
14.2		 2jihA-3lunA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		6 LEU A 188
THR A 225
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.46A 2jihA-3lunA:
14.2		 2jihA-3lunA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2x COLLAGENASE 3

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A1185
HIS A1222
GLU A1223
HIS A1226
HIS A1232
 3O2  A1801 (-4.0A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
 0.40A 2jihA-3o2xA:
10.2		 2jihA-3o2xA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6c PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		PF03740
(PdxJ) 		5 ASP A  51
HIS A  41
GLU A  92
HIS A  48
LEU A  67
 None
None
None
PO4  A 302 (-3.9A)
None
 1.48A 2jihA-3o6cA:
undetectable		 2jihA-3o6cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		5 LEU A 314
HIS A 348
GLU A 349
HIS A 352
HIS A 358
 None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.9A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 3.2A)
 0.43A 2jihA-3p24A:
15.0		 2jihA-3p24A:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		8 ASP A 116
LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
MET A 181
 None
QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
None
 0.77A 2jihA-3q2hA:
47.4		 2jihA-3q2hA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		8 LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
MET A 181
LEU A 182
 QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
None
QHF  A   1 (-4.7A)
 0.76A 2jihA-3q2hA:
47.4		 2jihA-3q2hA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shi INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.32A 2jihA-3shiA:
10.2		 2jihA-3shiA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v96 STROMELYSIN-2

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.38A 2jihA-3v96B:
10.4		 2jihA-3v96B:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		5 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 None
ZN  A 500 (-3.2A)
ZN  A 500 ( 4.2A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.2A)
 0.36A 2jihA-3vi1A:
6.7		 2jihA-3vi1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtg HIGH CHORIOLYTIC
ENZYME 1

(Oryzias latipes) 		PF01400
(Astacin) 		5 ASP A 148
THR A 112
HIS A 109
HIS A 103
HIS A  99
 None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 1.49A 2jihA-3vtgA:
7.7		 2jihA-3vtgA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 FLX  A 400 (-4.0A)
FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 1.21A 2jihA-4aigA:
25.6		 2jihA-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.31A 2jihA-4aigA:
25.6		 2jihA-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
HIS A 146
HIS A 152
LEU A 170
 FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
FLX  A 400 (-4.0A)
 0.90A 2jihA-4aigA:
25.6		 2jihA-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF01421
(Reprolysin) 		5 THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
 BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.36A 2jihA-4dd8A:
26.4		 2jihA-4dd8A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 ASP A  89
THR A 223
GLU A 222
HIS A 219
HIS A 192
 None
None
NOS  A 501 (-3.0A)
NOS  A 501 (-3.5A)
NOS  A 501 (-4.0A)
 1.04A 2jihA-4f0sA:
undetectable		 2jihA-4f0sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr8 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		6 LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.48A 2jihA-4gr8A:
10.6		 2jihA-4gr8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		5 THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
 None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.41A 2jihA-4gwnA:
7.2		 2jihA-4gwnA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		5 LEU A 164
HIS A 195
HIS A  14
HIS A  12
LEU A 194
 None
ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.6A)
None
 1.49A 2jihA-4hjwA:
undetectable		 2jihA-4hjwA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4in9 KARILYSIN PROTEASE

(Tannerella
forsythia) 		PF00413
(Peptidase_M10) 		5 LEU A 115
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.60A 2jihA-4in9A:
9.9		 2jihA-4in9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
 0.25A 2jihA-4j4mA:
26.5		 2jihA-4j4mA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXA

(Escherichia
coli) 		PF16313
(DUF4953) 		6 LEU A 122
THR A 176
HIS A 179
GLU A 180
HIS A 183
HIS A 189
 None
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.37A 2jihA-4l63A:
6.7		 2jihA-4l63A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 ASP B 253
HIS B  91
HIS B  57
HIS B  82
LEU B 247
 None
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
 1.16A 2jihA-4ouaB:
undetectable		 2jihA-4ouaB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 302 (-3.2A)
ZN  A 302 ( 4.7A)
ZN  A 302 (-3.1A)
ZN  A 302 (-3.1A)
 0.29A 2jihA-4q1lA:
26.1		 2jihA-4q1lA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhi UNCHARACTERIZED
PROTEIN MJ1213

(Methanocaldococcus
jannaschii) 		PF01435
(Peptidase_M48) 		5 HIS A  69
GLU A  70
HIS A  73
HIS A  80
LEU A  99
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
None
 0.73A 2jihA-4qhiA:
2.5		 2jihA-4qhiA:
14.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		7 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.37A 2jihA-4wk7A:
36.1		 2jihA-4wk7A:
53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 226
GLU A 227
HIS A 230
HIS A 236
MET A 247
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
None
 0.52A 2jihA-4xctA:
11.0		 2jihA-4xctA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.43A 2jihA-4xctA:
11.0		 2jihA-4xctA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvi SLOR

(Streptococcus
mutans) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		5 LEU A 101
HIS A  76
GLU A 102
HIS A  95
LEU A  83
 None
ZN  A 303 (-3.2A)
ZN  A 301 (-3.0A)
ZN  A 303 (-3.1A)
None
 1.08A 2jihA-5cviA:
undetectable		 2jihA-5cviA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		5 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 None
ZN  A 301 ( 3.4A)
ZN  A 301 ( 4.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.1A)
 0.37A 2jihA-5czwA:
7.1		 2jihA-5czwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 THR  A 173 ( 0.8A)
HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.40A 2jihA-5d7wA:
7.0		 2jihA-5d7wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0u MATRIX
METALLOPROTEINASE-14

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.40A 2jihA-5h0uA:
10.1		 2jihA-5h0uA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C

(Schizosaccharomyces
pombe) 		PF08325
(WLM) 		6 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.44A 2jihA-5jigA:
3.9		 2jihA-5jigA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nl9 TRANSCRIPTIONAL
REGULATOR (FUR
FAMILY)

(Leptospira
interrogans) 		no annotation 5 ASP A  95
THR A 138
HIS A  92
HIS A  90
HIS A  36
 None
None
ZN  A 201 (-3.3A)
ZN  A 201 (-3.3A)
ZN  A 201 (-3.2A)
 1.40A 2jihA-5nl9A:
undetectable		 2jihA-5nl9A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio rerio;
Escherichia
coli) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 LEU A1260
HIS A1158
HIS A1101
MET A1189
LEU A1190
 None
GNS  A1402 ( 3.9A)
A3P  A1401 (-3.9A)
None
None
 1.32A 2jihA-5t03A:
undetectable		 2jihA-5t03A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		6 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
MET A 422
 None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
None
 0.49A 2jihA-5th6A:
9.2		 2jihA-5th6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		5 HIS A 223
GLU A 198
HIS A 179
HIS A   6
LEU A 259
 None
None
ZN  A 400 (-3.2A)
ZN  A 400 (-3.3A)
None
 1.27A 2jihA-5vn5A:
undetectable		 2jihA-5vn5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbn WSS1P

(Saccharomyces
cerevisiae) 		no annotation 6 LEU A  80
THR A 112
HIS A 115
GLU A 116
HIS A 119
HIS A 125
 None
None
ZN  A 201 (-3.2A)
ZN  A 201 ( 4.7A)
ZN  A 201 (-3.3A)
ZN  A 201 (-3.2A)
 0.29A 2jihA-5xbnA:
4.2		 2jihA-5xbnA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		5 LEU A 173
THR A 279
GLU A 178
HIS A 254
HIS A 271
 None
None
None
ZN  A 401 (-3.4A)
ZN  A 401 ( 3.4A)
 1.41A 2jihA-5xn8A:
undetectable		 2jihA-5xn8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 5 LEU A 179
THR A 258
HIS A 256
HIS A 227
LEU A 204
 None
 1.47A 2jihA-5xpgA:
3.8		 2jihA-5xpgA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 569
THR A 537
HIS A 540
GLU A 541
HIS A 544
 None
None
ZN  A 802 (-3.4A)
None
ZN  A 802 (-3.3A)
 0.52A 2jihA-6az0A:
undetectable		 2jihA-6az0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 5 ASP A 325
HIS A 383
GLU A 384
HIS A 387
HIS A 393
 None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
 0.77A 2jihA-6bdzA:
20.0		 2jihA-6bdzA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 6 LEU A 328
THR A 380
HIS A 383
GLU A 384
HIS A 387
HIS A 393
 None
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
 0.69A 2jihA-6bdzA:
20.0		 2jihA-6bdzA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5c 3-DEHYDROQUINATE
SYNTHASE

(Candida
albicans) 		no annotation 5 LEU A 279
HIS A 280
GLU A 271
HIS A 268
HIS A 264
 None
None
None
None
EDO  A 409 ( 4.8A)
 1.44A 2jihA-6c5cA:
undetectable		 2jihA-6c5cA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 5 LEU A 318
THR A 376
HIS A 379
GLU A 380
HIS A 383
 LYS  A 606 ( 4.1A)
None
ZN  A 601 (-3.2A)
None
ZN  A 601 (-3.2A)
 0.64A 2jihA-6eomA:
undetectable		 2jihA-6eomA:
13.77