SIMILAR PATTERNS OF AMINO ACIDS FOR 2JFA_B_RALB600_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A  27
THR A  14
ILE A 164
HIS A 163
 None
 1.14A 2jfaB-1h74A:
0.0		 2jfaB-1h74A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuy CULLIN-3 HOMOLOGUE

(Mus musculus) 		PF10557
(Cullin_Nedd8) 		4 LEU A  78
THR A  89
ILE A  65
HIS A  43
 None
 1.25A 2jfaB-1iuyA:
undetectable		 2jfaB-1iuyA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		4 LEU A 143
THR A 141
ILE A 151
HIS A  99
 None
NAD  A1201 ( 4.1A)
None
None
 1.31A 2jfaB-1kaeA:
0.0		 2jfaB-1kaeA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khy CLPB PROTEIN

(Escherichia
coli) 		PF02861
(Clp_N) 		4 LEU A 122
THR A 121
ILE A  29
HIS A  33
 None
 1.30A 2jfaB-1khyA:
undetectable		 2jfaB-1khyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 LEU A 427
THR A 428
ILE A 318
HIS A 416
 None
 1.42A 2jfaB-1lw3A:
0.0		 2jfaB-1lw3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 152
THR A 148
ILE A 186
HIS A 299
 None
 1.40A 2jfaB-1n8pA:
undetectable		 2jfaB-1n8pA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		4 LEU A  56
THR A  57
ILE A  48
HIS A  41
 None
 1.32A 2jfaB-1o6dA:
undetectable		 2jfaB-1o6dA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		4 LEU A 211
THR A 210
ILE A  36
HIS A 189
 None
None
T5A  A 501 (-4.5A)
None
 1.29A 2jfaB-1p75A:
undetectable		 2jfaB-1p75A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
THR A 347
ILE A 424
HIS A 524
 EST  A   1 (-4.4A)
None
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
 0.82A 2jfaB-1pcgA:
32.8		 2jfaB-1pcgA:
98.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 4 LEU B 206
THR B 196
ILE B  84
HIS B 310
 None
 1.42A 2jfaB-1tahB:
0.0		 2jfaB-1tahB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni) 		PF13580
(SIS_2) 		4 LEU A 180
THR A 179
ILE A 117
HIS A 173
 None
 1.17A 2jfaB-1tk9A:
undetectable		 2jfaB-1tk9A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LEU A 167
THR A  88
ILE A 148
HIS A 143
 None
 1.34A 2jfaB-1u5qA:
undetectable		 2jfaB-1u5qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7h ORNITHINE
CYCLODEAMINASE

(Pseudomonas
putida) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 118
THR A 116
ILE A 197
HIS A 221
 None
 1.32A 2jfaB-1u7hA:
undetectable		 2jfaB-1u7hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 LEU A 847
THR A 845
ILE A 826
HIS A 823
 None
 1.03A 2jfaB-1urjA:
undetectable		 2jfaB-1urjA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		4 LEU A 178
THR A 179
ILE B 270
HIS B 226
 None
 0.76A 2jfaB-1w2wA:
undetectable		 2jfaB-1w2wA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5k NEOGENIN

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A  86
THR A  36
ILE A  56
HIS A  81
 None
 1.06A 2jfaB-1x5kA:
undetectable		 2jfaB-1x5kA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 LEU A   8
THR A   9
ILE A  46
HIS A   5
 None
 1.26A 2jfaB-1xqaA:
undetectable		 2jfaB-1xqaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A 110
THR A 111
ILE A 123
HIS A 134
 None
 1.36A 2jfaB-1y6lA:
undetectable		 2jfaB-1y6lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		4 LEU A 487
THR A 488
ILE A 257
HIS A 395
 None
 1.32A 2jfaB-2eijA:
undetectable		 2jfaB-2eijA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 LEU A 313
THR A 314
ILE A 472
HIS A 471
 TFC  A 600 (-4.2A)
TFC  A 600 ( 4.6A)
None
TFC  A 600 (-4.2A)
 1.26A 2jfaB-2fj0A:
undetectable		 2jfaB-2fj0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 LEU A 447
THR A 263
ILE A 352
HIS A 347
 None
 1.41A 2jfaB-2fwrA:
undetectable		 2jfaB-2fwrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LEU A 167
THR A  88
ILE A 148
HIS A 143
 None
 1.32A 2jfaB-2gcdA:
undetectable		 2jfaB-2gcdA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		4 LEU A  66
THR A  68
ILE A 181
HIS A 200
 None
 1.36A 2jfaB-2gv8A:
undetectable		 2jfaB-2gv8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1) 		4 LEU A 121
THR A 122
ILE A 144
HIS A 145
 None
 1.37A 2jfaB-2l4oA:
undetectable		 2jfaB-2l4oA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn5 HYPOTHETICAL PROTEIN
EF_2215

(Enterococcus
faecalis) 		PF08327
(AHSA1) 		4 LEU A 155
THR A 156
ILE A 147
HIS A 150
 EDO  A 301 ( 4.3A)
None
None
None
 1.22A 2jfaB-2nn5A:
undetectable		 2jfaB-2nn5A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
THR A 347
ILE A 424
HIS A 524
 EST  A 596 (-4.4A)
None
EST  A 596 ( 4.7A)
EST  A 596 (-4.2A)
 0.79A 2jfaB-2ocfA:
31.6		 2jfaB-2ocfA:
91.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot2 HYDROGENASE
ISOENZYMES FORMATION
PROTEIN HYPC

(Escherichia
coli) 		PF01455
(HupF_HypC) 		4 LEU A  71
THR A  67
ILE A   3
HIS A  51
 None
 1.15A 2jfaB-2ot2A:
undetectable		 2jfaB-2ot2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		4 LEU A  35
THR A  36
ILE A  26
HIS A  29
 None
 1.36A 2jfaB-2q14A:
undetectable		 2jfaB-2q14A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9l HYPOTHETICAL PROTEIN

(Vibrio sp.
DAT722) 		PF03819
(MazG) 		4 LEU A  77
THR A  80
ILE A  72
HIS A  73
 None
 1.37A 2jfaB-2q9lA:
undetectable		 2jfaB-2q9lA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 LEU A 640
THR A 641
ILE A 611
HIS A 610
 None
 1.03A 2jfaB-2qvwA:
undetectable		 2jfaB-2qvwA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 LEU G 781
THR G 777
ILE G1082
HIS G1078
 None
 1.31A 2jfaB-2uv8G:
undetectable		 2jfaB-2uv8G:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		4 LEU A 268
THR A 269
ILE A  19
HIS A 404
 None
 1.33A 2jfaB-2z3tA:
undetectable		 2jfaB-2z3tA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 LEU A 144
THR A 143
ILE A 396
HIS A 393
 None
 1.41A 2jfaB-2ztgA:
undetectable		 2jfaB-2ztgA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 ALPHAA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		4 LEU A  63
THR A  64
ILE A  55
HIS A  58
 None
None
None
HEM  A 142 (-4.7A)
 1.26A 2jfaB-3at6A:
undetectable		 2jfaB-3at6A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		4 LEU A 465
THR A 466
ILE A 292
HIS A 300
 None
 1.25A 2jfaB-3danA:
1.9		 2jfaB-3danA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hb7 ISOCHORISMATASE
HYDROLASE

(Alkaliphilus
metalliredigens) 		PF00857
(Isochorismatase) 		4 LEU A 147
THR A 146
ILE A  49
HIS A   4
 None
 1.32A 2jfaB-3hb7A:
undetectable		 2jfaB-3hb7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN REGULATORY
LIGHT CHAIN 2,
SMOOTH MUSCLE MAJOR
ISOFORM

(Gallus gallus) 		PF13405
(EF-hand_6)
PF13833
(EF-hand_8) 		4 LEU B 126
THR B 127
ILE B 117
HIS B 121
 None
 1.40A 2jfaB-3j04B:
undetectable		 2jfaB-3j04B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 LEU C 520
THR C 519
ILE C 551
HIS C 554
 None
 1.40A 2jfaB-3j9uC:
undetectable		 2jfaB-3j9uC:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr2 HEXULOSE-6-PHOSPHATE
SYNTHASE SGBH

(Vibrio cholerae) 		PF00215
(OMPdecase) 		4 LEU A  15
THR A  16
ILE A  32
HIS A  54
 None
 1.35A 2jfaB-3jr2A:
undetectable		 2jfaB-3jr2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 LEU A 375
THR A 374
ILE A 226
HIS A 378
 None
 1.15A 2jfaB-3k9dA:
undetectable		 2jfaB-3k9dA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00926
(DHBP_synthase) 		4 LEU A 181
THR A 178
ILE A  35
HIS A 144
 None
None
None
SO4  A 300 (-4.1A)
 1.20A 2jfaB-3mgzA:
undetectable		 2jfaB-3mgzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt0 UNCHARACTERIZED
PROTEIN PA1789

(Pseudomonas
aeruginosa) 		PF00582
(Usp) 		4 LEU A 169
THR A 168
ILE A 172
HIS A 216
 None
 0.97A 2jfaB-3mt0A:
undetectable		 2jfaB-3mt0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		4 LEU A  76
THR A  72
ILE A  66
HIS A  67
 None
 1.33A 2jfaB-3o8jA:
undetectable		 2jfaB-3o8jA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oes GTPASE RHEBL1

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A  58
THR A  42
ILE A  46
HIS A  55
 None
 1.30A 2jfaB-3oesA:
undetectable		 2jfaB-3oesA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdw UNCHARACTERIZED
HYDROLASE YUTF

(Bacillus
subtilis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A 204
THR A 203
ILE A 258
HIS A 262
 None
None
None
ACY  A 269 (-4.0A)
 1.18A 2jfaB-3pdwA:
undetectable		 2jfaB-3pdwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 LEU A 880
THR A 616
ILE A 607
HIS A 876
 None
 1.39A 2jfaB-3pihA:
undetectable		 2jfaB-3pihA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 LEU A 419
THR A 420
ILE A 348
HIS A 351
 None
 1.36A 2jfaB-3sucA:
undetectable		 2jfaB-3sucA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		4 LEU A 244
THR A 245
ILE A 455
HIS A 242
 None
 1.13A 2jfaB-3t66A:
undetectable		 2jfaB-3t66A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 LEU A  68
THR A  67
ILE A 139
HIS A  61
 None
 1.26A 2jfaB-4ah6A:
undetectable		 2jfaB-4ah6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 LEU A 564
THR A 580
ILE A 458
HIS A 457
 None
 1.22A 2jfaB-4bugA:
1.7		 2jfaB-4bugA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4erv RYANODINE RECEPTOR 3

(Homo sapiens) 		PF02026
(RyR) 		4 LEU A2660
THR A2661
ILE A2654
HIS A2651
 None
None
None
GOL  A2904 (-3.8A)
 1.11A 2jfaB-4ervA:
undetectable		 2jfaB-4ervA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		4 LEU A 584
THR A 585
ILE A  64
HIS A  68
 None
 1.14A 2jfaB-4ex4A:
undetectable		 2jfaB-4ex4A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 LEU A 275
THR A 334
ILE A 268
HIS A 267
 None
 1.23A 2jfaB-4gvlA:
undetectable		 2jfaB-4gvlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA

(Mycobacterium
tuberculosis) 		PF00925
(GTP_cyclohydro2)
PF00926
(DHBP_synthase) 		4 LEU A 181
THR A 178
ILE A  35
HIS A 144
 None
None
None
SO4  A 502 (-4.0A)
 1.27A 2jfaB-4i14A:
undetectable		 2jfaB-4i14A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldc DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA

(Rattus
norvegicus) 		PF00168
(C2) 		4 LEU A 351
THR A 350
ILE A 270
HIS A 399
 None
 1.14A 2jfaB-4ldcA:
undetectable		 2jfaB-4ldcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE

(Thermococcus
onnurineus) 		PF02006
(PPS_PS) 		4 LEU A 249
THR A 247
ILE A  47
HIS A 241
 None
 0.98A 2jfaB-4mb2A:
undetectable		 2jfaB-4mb2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxw LYMPHOTOXIN-BETA

(Homo sapiens) 		no annotation 4 LEU Y 113
THR Y 114
ILE Y  93
HIS Y  91
 None
 1.22A 2jfaB-4mxwY:
undetectable		 2jfaB-4mxwY:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 232
THR A 230
ILE A 346
HIS A 184
 None
 1.39A 2jfaB-4nzsA:
undetectable		 2jfaB-4nzsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo0 MAF-LIKE PROTEIN
BCAL2394

(Burkholderia
cenocepacia) 		PF02545
(Maf) 		4 LEU A 128
THR A  95
ILE A  99
HIS A 125
 None
 1.07A 2jfaB-4oo0A:
undetectable		 2jfaB-4oo0A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oou BETA-1,4-MANNANASE

(Cryptopygus
antarcticus) 		no annotation 4 LEU B 263
THR B 264
ILE B 229
HIS B 230
 None
 0.91A 2jfaB-4oouB:
undetectable		 2jfaB-4oouB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 LEU A 218
THR A 217
ILE A  94
HIS A 221
 None
 1.26A 2jfaB-4ox2A:
undetectable		 2jfaB-4ox2A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmj PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF00248
(Aldo_ket_red) 		4 LEU A 262
THR A 259
ILE A 255
HIS A 216
 None
 1.41A 2jfaB-4pmjA:
undetectable		 2jfaB-4pmjA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaz NUCLEOPROTEIN

(Zaire
ebolavirus) 		PF05505
(Ebola_NP) 		4 LEU A 700
THR A 701
ILE A 734
HIS A 738
 None
 1.16A 2jfaB-4qazA:
undetectable		 2jfaB-4qazA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsx TYPE III EFFECTOR
HOPA1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 LEU A 177
THR A 176
ILE A 268
HIS A 273
 None
 1.25A 2jfaB-4rsxA:
undetectable		 2jfaB-4rsxA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtb CALCIUM UNIPORTER
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 LEU A 101
THR A 100
ILE A 104
HIS A 170
 None
None
None
PG4  A1001 (-3.5A)
 1.22A 2jfaB-4xtbA:
undetectable		 2jfaB-4xtbA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 LEU A 115
THR A 117
ILE A 235
HIS A 238
 None
 1.35A 2jfaB-4yj1A:
undetectable		 2jfaB-4yj1A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 305
THR A 306
ILE A  76
HIS A  99
 None
 1.20A 2jfaB-5a05A:
undetectable		 2jfaB-5a05A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Burkholderia
cenocepacia) 		PF00005
(ABC_tran) 		4 LEU C 229
THR C 233
ILE C 226
HIS C 237
 None
 1.38A 2jfaB-5b57C:
undetectable		 2jfaB-5b57C:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 LEU A 347
THR A 346
ILE A 362
HIS A 350
 None
 1.22A 2jfaB-5bwiA:
undetectable		 2jfaB-5bwiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2h BETA-LACTAMASE

(Mycolicibacterium
smegmatis) 		PF00144
(Beta-lactamase) 		4 LEU A 167
THR A 165
ILE A 155
HIS A 154
 None
 1.14A 2jfaB-5e2hA:
undetectable		 2jfaB-5e2hA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 LEU A 554
THR A 555
ILE A 481
HIS A 475
 None
 1.23A 2jfaB-5f7uA:
undetectable		 2jfaB-5f7uA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 LEU A 470
THR A 469
ILE A 463
HIS A 552
 None
 0.97A 2jfaB-5ficA:
undetectable		 2jfaB-5ficA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fii PHENYLALANINE-4-HYDR
OXYLASE

(Homo sapiens) 		PF01842
(ACT) 		4 LEU A  91
THR A  92
ILE A  38
HIS A 107
 None
 1.05A 2jfaB-5fiiA:
undetectable		 2jfaB-5fiiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		4 LEU H 217
THR H 222
ILE H 314
HIS H 213
 None
 1.10A 2jfaB-5g06H:
undetectable		 2jfaB-5g06H:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4v GLUTAMATE--TRNA
LIGASE

(Xanthomonas
oryzae) 		no annotation 4 LEU A 231
THR A 236
ILE A  17
HIS A  16
 None
 1.33A 2jfaB-5h4vA:
undetectable		 2jfaB-5h4vA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 LEU A 470
THR A 469
ILE A 463
HIS A 552
 None
 1.03A 2jfaB-5hqnA:
undetectable		 2jfaB-5hqnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 LEU A 729
THR A 730
ILE A 557
HIS A 724
 None
 1.04A 2jfaB-5ikzA:
0.9		 2jfaB-5ikzA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9h ENVELOPMENT
POLYPROTEIN

(Puumala
orthohantavirus) 		PF01561
(Hanta_G2) 		4 LEU A1006
THR A1007
ILE A1016
HIS A1056
 None
 1.07A 2jfaB-5j9hA:
undetectable		 2jfaB-5j9hA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5klp ORF34

(Pseudomonas
syringae) 		PF03421
(Acetyltransf_14) 		4 LEU A 246
THR A 245
ILE A 166
HIS A 238
 None
 1.31A 2jfaB-5klpA:
undetectable		 2jfaB-5klpA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljy ENVELOPMENT
POLYPROTEIN

(Hantaan
orthohantavirus) 		PF01561
(Hanta_G2) 		4 LEU A 349
THR A 350
ILE A 359
HIS A 399
 None
 1.25A 2jfaB-5ljyA:
undetectable		 2jfaB-5ljyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 LEU A 458
THR A 457
ILE A 448
HIS A 447
 None
 1.26A 2jfaB-5muxA:
undetectable		 2jfaB-5muxA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9m COBYRIC ACID
SYNTHASE

(Staphylococcus
aureus) 		no annotation 4 LEU A  91
THR A  92
ILE A  20
HIS A   8
 None
 1.37A 2jfaB-5n9mA:
undetectable		 2jfaB-5n9mA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 4 LEU A 264
THR A 263
ILE A 307
HIS A 331
 None
 1.31A 2jfaB-5no5A:
undetectable		 2jfaB-5no5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 LEU A 313
THR A 309
ILE A 279
HIS A 302
 None
 1.31A 2jfaB-5nqdA:
undetectable		 2jfaB-5nqdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oaf RUVB-LIKE 1

(Homo sapiens) 		no annotation 4 LEU A 410
THR A 411
ILE A 377
HIS A  20
 None
None
None
ADP  A 501 (-3.7A)
 1.40A 2jfaB-5oafA:
undetectable		 2jfaB-5oafA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 577
THR A 578
ILE A  64
HIS A  68
 None
 1.20A 2jfaB-5oasA:
undetectable		 2jfaB-5oasA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt RIBOSOMAL PROTEIN
S7, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 LEU Q  54
THR Q  53
ILE Q 173
HIS Q 176
 None
A  E 765 ( 4.9A)
None
None
 1.10A 2jfaB-5optQ:
undetectable		 2jfaB-5optQ:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK

(Candidatus
Pelagibacter
ubique) 		PF07883
(Cupin_2) 		4 LEU A  55
THR A  54
ILE A  90
HIS A  58
 None
None
None
NI  A 201 ( 3.3A)
 1.35A 2jfaB-5tfzA:
undetectable		 2jfaB-5tfzA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 298
THR A 299
ILE A 376
HIS A 475
 EST  A 601 (-4.1A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
 0.71A 2jfaB-5toaA:
29.0		 2jfaB-5toaA:
53.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		4 LEU A 254
THR A 256
ILE A 403
HIS A 404
 None
 1.18A 2jfaB-5uaoA:
undetectable		 2jfaB-5uaoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC

(Medicago
truncatula) 		PF00815
(Histidinol_dh) 		4 LEU A 179
THR A 177
ILE A 187
HIS A 135
 None
 1.32A 2jfaB-5vldA:
undetectable		 2jfaB-5vldA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 LEU A 277
THR A 278
ILE A 255
HIS A 251
 None
 1.29A 2jfaB-5vylA:
undetectable		 2jfaB-5vylA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2b NUCLEOPROTEIN

(Reston
ebolavirus) 		no annotation 4 LEU A 700
THR A 701
ILE A 734
HIS A 738
 None
 1.07A 2jfaB-5w2bA:
undetectable		 2jfaB-5w2bA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3v APOBEC3H

(Macaca
nemestrina) 		no annotation 4 LEU B  80
THR B  81
ILE B  57
HIS B  54
 None
None
None
ZN  B 301 (-3.1A)
 1.32A 2jfaB-5w3vB:
undetectable		 2jfaB-5w3vB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 4 LEU A 320
THR A 323
ILE A 315
HIS A 191
 None
 1.35A 2jfaB-5wa3A:
1.9		 2jfaB-5wa3A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd2 NUDIX FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		4 LEU A 240
THR A 241
ILE A 223
HIS A 220
 None
 1.09A 2jfaB-5xd2A:
undetectable		 2jfaB-5xd2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 4 LEU A  47
THR A  11
ILE A   4
HIS A   8
 None
 1.39A 2jfaB-5z95A:
undetectable		 2jfaB-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		4 LEU A 583
THR A 584
ILE A  64
HIS A  68
 None
 1.20A 2jfaB-6axeA:
undetectable		 2jfaB-6axeA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G

(Pyrococcus
furiosus) 		no annotation 4 LEU B  73
THR B  72
ILE F   8
HIS C  92
 None
 1.14A 2jfaB-6cfwB:
undetectable		 2jfaB-6cfwB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 4 LEU A 152
THR A 151
ILE A 179
HIS A 145
 None
 1.34A 2jfaB-6et7A:
undetectable		 2jfaB-6et7A:
14.91