SIMILAR PATTERNS OF AMINO ACIDS FOR 2JFA_B_RALB600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 ALA A  22
GLU A  25
LEU A  26
GLY A 201
LEU A  14
 None
 1.12A 2jfaB-1bjnA:
undetectable		 2jfaB-1bjnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 ALA A 380
LEU A 382
LEU A  27
GLY A 397
LEU A 398
 None
 1.12A 2jfaB-1c0nA:
undetectable		 2jfaB-1c0nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		5 ALA A 775
ASP A 778
LEU A 777
LEU A 630
GLY A 768
 None
 1.11A 2jfaB-1nd7A:
undetectable		 2jfaB-1nd7A:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ALA A 350
ASP A 351
GLU A 353
LEU A 354
TRP A 383
LEU A 387
LEU A 391
ARG A 394
 EST  A   1 ( 3.7A)
None
EST  A   1 (-2.8A)
None
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
 0.85A 2jfaB-1pcgA:
32.8		 2jfaB-1pcgA:
98.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ALA A 350
ASP A 351
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
LEU A 525
 EST  A   1 ( 3.7A)
None
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 (-3.6A)
 0.81A 2jfaB-1pcgA:
32.8		 2jfaB-1pcgA:
98.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
ALA A 350
GLU A 353
LEU A 354
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
GLY A 521
 EST  A   1 ( 4.0A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 ( 4.1A)
 0.61A 2jfaB-1pcgA:
32.8		 2jfaB-1pcgA:
98.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
GLY A 521
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.6A)
 0.68A 2jfaB-1pcgA:
32.8		 2jfaB-1pcgA:
98.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		6 ALA A 231
GLU A 230
LEU A 234
LEU A 226
LEU A 224
LEU A  63
 None
 1.15A 2jfaB-1sgvA:
undetectable		 2jfaB-1sgvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 102
LEU A 147
ARG A  27
GLY A 137
LEU A 156
 None
None
None
UMA  A 963 (-4.3A)
None
 1.01A 2jfaB-1uagA:
undetectable		 2jfaB-1uagA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 343
TRP A 376
LEU A 380
ARG A 387
GLY A 500
 MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
None
 0.84A 2jfaB-1uhlA:
22.6		 2jfaB-1uhlA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 343
TRP A 376
LEU A 380
ARG A 387
LEU A 507
 MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
MEI  A1001 (-4.6A)
 0.72A 2jfaB-1uhlA:
22.6		 2jfaB-1uhlA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 347
TRP A 376
LEU A 380
ARG A 387
GLY A 500
 None
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
None
 0.91A 2jfaB-1uhlA:
22.6		 2jfaB-1uhlA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		5 ALA A1908
ASP A1906
LEU A1766
GLY A1758
LEU A1777
 None
 1.10A 2jfaB-1uyvA:
undetectable		 2jfaB-1uyvA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		5 ALA A 426
ASP A 429
LEU A 428
GLY A  12
LEU A  16
 None
 1.10A 2jfaB-1v6cA:
undetectable		 2jfaB-1v6cA:
17.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASP A 329
GLU A 331
TRP A 361
LEU A 365
ARG A 372
 None
 1.00A 2jfaB-1xb7A:
24.8		 2jfaB-1xb7A:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 331
TRP A 361
LEU A 365
ARG A 372
GLY A 489
 None
 0.77A 2jfaB-1xb7A:
24.8		 2jfaB-1xb7A:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 ALA A 246
ASP A 247
LEU A 283
ARG A 290
LEU A 410
 9CR  A 201 (-3.6A)
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-2.8A)
9CR  A 201 ( 4.8A)
 1.09A 2jfaB-1xiuA:
22.9		 2jfaB-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		6 ALA A 246
LEU A 250
TRP A 279
LEU A 283
ARG A 290
GLY A 403
 9CR  A 201 (-3.6A)
None
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-2.8A)
None
 0.89A 2jfaB-1xiuA:
22.9		 2jfaB-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 ALA A 246
TRP A 279
LEU A 283
ARG A 290
LEU A 410
 9CR  A 201 (-3.6A)
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-2.8A)
9CR  A 201 ( 4.8A)
 0.82A 2jfaB-1xiuA:
22.9		 2jfaB-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
LEU A 276
TRP A 305
ARG A 316
GLY A 429
 9CR  A 801 (-3.5A)
None
None
9CR  A 801 (-2.6A)
None
 0.97A 2jfaB-1xlsA:
22.6		 2jfaB-1xlsA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
TRP A 305
LEU A 309
ARG A 316
GLY A 429
 9CR  A 801 (-3.5A)
None
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
None
 0.95A 2jfaB-1xlsA:
22.6		 2jfaB-1xlsA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A 801 (-3.5A)
None
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.7A)
 0.85A 2jfaB-1xlsA:
22.6		 2jfaB-1xlsA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		5 ALA A  86
GLU A  85
LEU A  89
GLY A 103
LEU A 101
 None
 1.00A 2jfaB-1xqwA:
undetectable		 2jfaB-1xqwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xss FLUORESCENT PROTEIN

(Favia favus) 		PF01353
(GFP) 		5 GLU A 214
ARG A  66
MET A  14
GLY A  27
LEU A  42
 DYG  A  64 ( 3.7A)
DYG  A  64 ( 2.9A)
None
None
None
 1.08A 2jfaB-1xssA:
undetectable		 2jfaB-1xssA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus musculus) 		PF00104
(Hormone_recep) 		5 ALA A 270
ASP A 271
LEU A 307
ARG A 314
LEU A 438
 PEF  A 201 ( 4.4A)
None
PEF  A 201 (-4.0A)
None
None
 0.98A 2jfaB-1yp0A:
21.5		 2jfaB-1yp0A:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 ALA A 361
GLU A 357
LEU A 360
LEU A 226
GLY A 396
 None
 1.05A 2jfaB-1zb7A:
undetectable		 2jfaB-1zb7A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		6 ALA A 339
GLU A 335
LEU A 338
LEU A 207
ARG A 347
GLY A 373
 None
 1.42A 2jfaB-1zl6A:
undetectable		 2jfaB-1zl6A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btj GREEN TO RED
PHOTOCONVERTIBLE
GPF-LIKE PROTEIN
EOSFP

(Lobophyllia
hemprichii) 		PF01353
(GFP) 		5 GLU A 212
ARG A  66
MET A  14
GLY A  27
LEU A  42
 IEY  A  64 ( 3.6A)
IEY  A  64 ( 3.0A)
NFA  A  61 ( 3.7A)
None
NFA  A  61 ( 4.3A)
 1.05A 2jfaB-2btjA:
undetectable		 2jfaB-2btjA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 ALA A 536
LEU A 435
LEU A 333
GLY A 415
LEU A 414
 None
None
None
ADP  A1001 (-3.6A)
None
 1.08A 2jfaB-2d0oA:
undetectable		 2jfaB-2d0oA:
18.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ALA A 272
ASP A 273
GLU A 275
LEU A 276
TRP A 305
LEU A 309
ARG A 316
 OHT  A 500 (-3.5A)
OHT  A 500 (-3.1A)
OHT  A 500 (-2.6A)
OHT  A 500 (-4.9A)
None
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
 0.60A 2jfaB-2gpvA:
26.2		 2jfaB-2gpvA:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		5 GLU A 212
ARG A  66
MET A  14
GLY A  27
LEU A  42
 CR8  A  63 ( 3.6A)
CR8  A  63 ( 3.0A)
None
None
None
 1.08A 2jfaB-2gw3A:
undetectable		 2jfaB-2gw3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw4 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		5 GLU B 212
ARG B  66
MET A  14
GLY A  27
LEU A  42
 RC7  B  63 ( 3.5A)
RC7  B  63 ( 3.0A)
NFA  A  61 ( 3.7A)
None
NFA  A  61 ( 4.3A)
 1.08A 2jfaB-2gw4B:
undetectable		 2jfaB-2gw4B:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 ALA A 127
ASP A 128
GLU A 130
LEU A 131
GLY A  64
 None
 1.11A 2jfaB-2i44A:
undetectable		 2jfaB-2i44A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it2 UPF0130 PROTEIN
PH1069

(Pyrococcus
horikoshii) 		PF02676
(TYW3) 		5 ALA A  90
GLU A  89
LEU A  88
GLY A 161
LEU A  99
 None
 1.11A 2jfaB-2it2A:
undetectable		 2jfaB-2it2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		5 ALA A 269
GLU A 268
LEU A 272
LEU A 264
GLY A 255
 None
 1.09A 2jfaB-2nuxA:
undetectable		 2jfaB-2nuxA:
24.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASP A 351
GLU A 353
LEU A 387
ARG A 394
LEU A 525
 None
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
EST  A 596 (-3.6A)
 1.06A 2jfaB-2ocfA:
31.6		 2jfaB-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 MET A 343
ALA A 350
GLU A 353
TRP A 383
LEU A 387
ARG A 394
GLY A 521
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.0A)
EST  A 596 (-3.6A)
 0.75A 2jfaB-2ocfA:
31.6		 2jfaB-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
GLY A 521
 EST  A 596 (-4.8A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 ( 4.0A)
 0.56A 2jfaB-2ocfA:
31.6		 2jfaB-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
GLU A 353
LEU A 354
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
GLY A 521
 EST  A 596 (-4.8A)
EST  A 596 (-2.7A)
None
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 ( 4.0A)
 0.72A 2jfaB-2ocfA:
31.6		 2jfaB-2ocfA:
91.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		5 MET A 201
ALA A 208
ASP A 209
LEU A 212
LEU A 112
 None
 1.08A 2jfaB-2pzkA:
undetectable		 2jfaB-2pzkA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ALA A  36
TRP A  69
LEU A  77
ARG A  80
MET A 108
 1CA  A 247 (-3.6A)
None
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.63A 2jfaB-2q3yA:
24.3		 2jfaB-2q3yA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzx GREEN FLUORESCENT
PROTEIN

(Dendronephthya
sp. SSAL-2002) 		PF01353
(GFP) 		5 GLU A 211
ARG A  66
MET A  14
GLY A  27
LEU A  42
 CR8  A  64 ( 3.6A)
CR8  A  64 ( 4.3A)
None
None
None
 0.86A 2jfaB-2vzxA:
undetectable		 2jfaB-2vzxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x64 GLUTATHIONE-S-TRANSF
ERASE

(Xylella
fastidiosa) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ALA A 198
GLU A 202
LEU A 199
LEU A  12
GLY A 157
 None
 0.97A 2jfaB-2x64A:
undetectable		 2jfaB-2x64A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		5 ALA A 942
LEU A 945
LEU A 916
GLY A 887
LEU A 886
 None
 1.01A 2jfaB-2y35A:
undetectable		 2jfaB-2y35A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7k HALORHODOPSIN

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		5 TRP A 121
LEU A 125
LEU A 129
GLY A  84
LEU A  89
 None
None
L1P  A 293 ( 4.9A)
L1P  A 293 ( 4.5A)
L1P  A 293 (-4.4A)
 1.05A 2jfaB-3a7kA:
undetectable		 2jfaB-3a7kA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN

(Galaxea
fascicularis) 		PF01353
(GFP) 		5 GLU A 211
ARG A  66
MET A  14
GLY A  27
LEU A  42
 CRQ  A  64 ( 4.0A)
CRQ  A  64 ( 3.8A)
None
None
None
 0.92A 2jfaB-3adfA:
undetectable		 2jfaB-3adfA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5n PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00957
(Synaptobrevin)
no annotation 		5 MET C 482
ALA C 489
ASP C 490
GLY A  73
LEU D 640
 None
 1.08A 2jfaB-3b5nC:
undetectable		 2jfaB-3b5nC:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmb REGULATOR OF
NUCLEOSIDE
DIPHOSPHATE KINASE

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF14760
(Rnk_N) 		5 ALA A  36
ASP A  39
GLU A  37
LEU A  38
GLY A  27
 None
 1.12A 2jfaB-3bmbA:
undetectable		 2jfaB-3bmbA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clj PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF04818
(CTD_bind) 		5 ALA A 112
ASP A 111
LEU A 108
LEU A  66
GLY A  23
 None
 0.82A 2jfaB-3cljA:
undetectable		 2jfaB-3cljA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		5 ALA A 504
GLU A 503
LEU A 507
LEU A 429
GLY A 433
 None
 0.92A 2jfaB-3cuxA:
undetectable		 2jfaB-3cuxA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
GLY A 429
 9CR  A7223 (-4.2A)
None
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
None
 0.88A 2jfaB-3dzuA:
22.3		 2jfaB-3dzuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A7223 (-4.2A)
None
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
9CR  A7223 ( 4.7A)
 0.87A 2jfaB-3dzuA:
22.3		 2jfaB-3dzuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 ALA X  17
ASP X  18
GLU X  20
GLY X 205
LEU X 206
 None
 1.11A 2jfaB-3e13X:
undetectable		 2jfaB-3e13X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7c PROTEIN OF UNKNOWN
FUNCTION (DUF416)

(Marinobacter
hydrocarbonoclasticus) 		PF04222
(DUF416) 		5 ALA A  26
GLU A  27
LEU A  23
LEU A  52
LEU A  75
 None
 1.12A 2jfaB-3f7cA:
undetectable		 2jfaB-3f7cA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 MET A 723
ALA A 720
LEU A 717
GLY A 548
LEU A 543
 None
 1.09A 2jfaB-3gsiA:
undetectable		 2jfaB-3gsiA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjz TRANSALDOLASE B

(Prochlorococcus
marinus) 		PF00923
(TAL_FSA) 		5 ALA A 309
GLU A 312
LEU A 313
LEU A  40
GLY A  19
 NA  A 340 (-3.4A)
None
None
None
None
 0.98A 2jfaB-3hjzA:
undetectable		 2jfaB-3hjzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A  88
LEU A  14
ARG A 306
GLY A  22
LEU A  25
 None
 1.04A 2jfaB-3m9vA:
undetectable		 2jfaB-3m9vA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Clostridium
beijerinckii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  66
ASP A  65
LEU A  99
GLY A 104
LEU A 106
 None
 1.04A 2jfaB-3s47A:
undetectable		 2jfaB-3s47A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ALA A 240
GLU A 244
LEU A 242
ARG A 147
GLY A 233
 None
 1.01A 2jfaB-3s9vA:
undetectable		 2jfaB-3s9vA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx7 NUCLEAR RECEPTOR
SUBFAMILY 5 GROUP A
MEMBER 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA B 349
ASP B 350
LEU B 353
LEU B 386
ARG B 393
LEU B 517
 P6L  B 100 ( 3.9A)
None
None
P6L  B 100 (-3.8A)
None
P6L  B 100 (-4.1A)
 1.18A 2jfaB-3tx7B:
19.2		 2jfaB-3tx7B:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 329
ASP A 330
LEU A  35
MET A 110
LEU A 354
 None
 1.09A 2jfaB-3ugvA:
undetectable		 2jfaB-3ugvA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ALA A 341
LEU A 342
LEU A 304
GLY A 311
LEU A 323
 None
 1.11A 2jfaB-3wkyA:
undetectable		 2jfaB-3wkyA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zul FLUORESCENT PROTEIN
DRONPA

(Echinophyllia
sp. SC22) 		PF01353
(GFP) 		5 GLU A 211
ARG A  66
MET A  14
GLY A  27
LEU A  42
 GYC  A  63 ( 3.5A)
GYC  A  63 ( 2.9A)
None
None
None
 1.11A 2jfaB-3zulA:
undetectable		 2jfaB-3zulA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1d HYDANTOIN TRANSPORT
PROTEIN

(Microbacterium
liquefaciens) 		PF02133
(Transp_cyt_pur) 		5 MET A 214
ALA A 367
LEU A 366
LEU A 370
GLY A 433
 None
 1.09A 2jfaB-4d1dA:
undetectable		 2jfaB-4d1dA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxo LEA X(6) GFP-LIKE
PROTEINS

(synthetic
construct) 		PF01353
(GFP) 		5 GLU A 211
ARG A  66
MET A  14
GLY A  27
LEU A  42
 CR8  A  63 ( 4.0A)
CR8  A  63 ( 3.1A)
None
None
None
 1.11A 2jfaB-4dxoA:
undetectable		 2jfaB-4dxoA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 137
LEU A 138
LEU A 155
LEU A  94
GLY A 180
 None
 1.01A 2jfaB-4efiA:
undetectable		 2jfaB-4efiA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  64
ASP A  63
LEU A  97
GLY A 102
LEU A 104
 None
 1.04A 2jfaB-4hnlA:
undetectable		 2jfaB-4hnlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 6 ALA D 272
LEU D 276
TRP D 305
LEU D 309
ARG D 316
GLY D 429
 None
 0.94A 2jfaB-4j5xD:
21.2		 2jfaB-4j5xD:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 5 ALA D 272
TRP D 305
LEU D 309
ARG D 316
LEU D 436
 None
 0.80A 2jfaB-4j5xD:
21.2		 2jfaB-4j5xD:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium) 		PF00378
(ECH_1) 		6 ALA A 168
GLU A 167
LEU A 171
LEU A 163
GLY A 105
LEU A 108
 None
None
None
None
CL  A 301 (-3.6A)
None
 1.35A 2jfaB-4jylA:
undetectable		 2jfaB-4jylA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 ALA A 287
GLU A 290
LEU A 291
ARG A 331
GLY A 444
 None
 0.96A 2jfaB-4n1yA:
26.6		 2jfaB-4n1yA:
35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 ALA A 287
GLU A 290
LEU A 291
TRP A 320
LEU A 324
ARG A 331
GLY A 447
 None
 0.66A 2jfaB-4n1yA:
26.6		 2jfaB-4n1yA:
35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 ALA A 287
GLU A 290
TRP A 320
LEU A 324
ARG A 331
MET A 358
 None
 0.77A 2jfaB-4n1yA:
26.6		 2jfaB-4n1yA:
35.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 GLU A 219
ARG A 306
MET A 254
GLY A 267
LEU A 282
 CR8  A 303 ( 3.6A)
CR8  A 303 ( 2.9A)
None
None
None
 1.03A 2jfaB-4oy4A:
undetectable		 2jfaB-4oy4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified) 		PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3) 		5 ALA A  89
LEU A  90
LEU A  37
GLY A 115
LEU A 118
 None
 1.00A 2jfaB-4q3kA:
undetectable		 2jfaB-4q3kA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6t GLYCOSYL HYDROLASE,
FAMILY 18

(Pseudomonas
protegens) 		PF00704
(Glyco_hydro_18) 		5 ALA A  89
LEU A  49
MET A  78
GLY A  62
LEU A  61
 None
 1.09A 2jfaB-4q6tA:
undetectable		 2jfaB-4q6tA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus) 		PF13416
(SBP_bac_8) 		5 ALA A 163
ASP A 166
GLU A 164
LEU A 165
GLY A 296
 None
 0.98A 2jfaB-4r9gA:
undetectable		 2jfaB-4r9gA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 773
TRP A 806
LEU A 810
LEU A 814
ARG A 817
 CV7  A1987 (-3.5A)
None
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
 0.55A 2jfaB-4udbA:
23.8		 2jfaB-4udbA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN

(Homo sapiens) 		PF00975
(Thioesterase) 		5 ALA A 111
GLU A 121
LEU A 112
LEU A 200
LEU A 127
 None
 1.11A 2jfaB-4xjvA:
undetectable		 2jfaB-4xjvA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 ALA A 340
GLU A 336
LEU A 339
LEU A 208
GLY A 374
 None
 0.88A 2jfaB-4zktA:
undetectable		 2jfaB-4zktA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus) 		PF01036
(Bac_rhodopsin) 		5 LEU A 166
LEU A 187
LEU A 184
GLY A 112
LEU A 113
 None
 1.08A 2jfaB-5azdA:
undetectable		 2jfaB-5azdA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqk ICP27

(Human
alphaherpesvirus
1) 		PF05459
(Herpes_UL69) 		5 ALA A 356
ASP A 357
LEU A 360
LEU A 433
LEU A 472
 None
 1.12A 2jfaB-5bqkA:
undetectable		 2jfaB-5bqkA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eog PROTEIN MAB-21-LIKE
1

(Homo sapiens) 		PF03281
(Mab-21) 		5 ALA A 346
LEU A 345
LEU A 304
GLY A 297
LEU A   8
 None
 1.11A 2jfaB-5eogA:
undetectable		 2jfaB-5eogA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A 235
ASP A 236
LEU A 272
LEU A 267
LEU A 761
 None
 1.01A 2jfaB-5fjiA:
undetectable		 2jfaB-5fjiA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A 235
ASP A 236
LEU A 272
LEU A 267
LEU A 759
 None
 1.05A 2jfaB-5fjjA:
undetectable		 2jfaB-5fjjA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmm EXODEOXYRIBONUCLEASE

(Escherichia
virus T5) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		5 LEU A 159
TRP A 156
LEU A 149
GLY A  27
LEU A  66
 None
 1.11A 2jfaB-5hmmA:
undetectable		 2jfaB-5hmmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzx NUDIX (NUCLEOSIDE
DIPHOSPHATE LINKED
MOIETY X)-TYPE MOTIF
1

(Danio rerio) 		PF00293
(NUDIX) 		5 ALA A  49
GLU A  52
LEU A  53
LEU A   7
GLY A  68
 None
None
None
2GE  A 201 ( 4.0A)
None
 1.11A 2jfaB-5hzxA:
undetectable		 2jfaB-5hzxA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A 231
ASP A 232
LEU A 268
LEU A 263
LEU A 753
 None
 1.08A 2jfaB-5ju6A:
undetectable		 2jfaB-5ju6A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdt RPB7-BINDING PROTEIN
SEB1

(Schizosaccharomyces
pombe) 		PF04818
(CTD_bind) 		5 ALA A 110
ASP A 109
LEU A 106
LEU A  63
GLY A  20
 None
 0.99A 2jfaB-5mdtA:
undetectable		 2jfaB-5mdtA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 ALA A 563
TRP A 348
LEU A 421
LEU A 422
MET A 368
 None
 1.12A 2jfaB-5ohjA:
2.0		 2jfaB-5ohjA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		5 ALA A 723
ASP A 726
LEU A 725
LEU A 578
GLY A 716
 None
 1.07A 2jfaB-5tj7A:
undetectable		 2jfaB-5tj7A:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 295
ALA A 302
GLU A 305
TRP A 335
LEU A 339
LEU A 343
ARG A 346
GLY A 472
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 (-4.0A)
EST  A 601 (-3.5A)
 0.80A 2jfaB-5toaA:
29.0		 2jfaB-5toaA:
53.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 295
GLU A 305
LEU A 306
TRP A 335
LEU A 339
LEU A 343
ARG A 346
GLY A 472
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 (-2.4A)
None
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 (-4.0A)
EST  A 601 (-3.5A)
 0.91A 2jfaB-5toaA:
29.0		 2jfaB-5toaA:
53.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 6 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
GLY A 429
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
 1.05A 2jfaB-5uanA:
9.8		 2jfaB-5uanA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 5 ALA A 272
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
9CR  A 503 ( 4.8A)
 1.03A 2jfaB-5uanA:
9.8		 2jfaB-5uanA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3l VIRAL PROTEIN 3

(Rhinovirus B) 		PF00073
(Rhv) 		5 ALA B 213
LEU B 111
LEU B  97
LEU B  96
LEU B 219
 None
 0.94A 2jfaB-5w3lB:
undetectable		 2jfaB-5w3lB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 6 ALA A 117
LEU A 102
LEU A  94
LEU A  95
GLY A  66
LEU A  70
 None
 1.09A 2jfaB-5wbfA:
undetectable		 2jfaB-5wbfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 5 ALA A 174
LEU A 171
LEU A 105
LEU A 104
LEU A 112
 None
 1.08A 2jfaB-5xxgA:
undetectable		 2jfaB-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvd LIGHT CHAIN

(Clostridium
botulinum) 		no annotation 5 ALA A 355
GLU A 351
LEU A 354
LEU A 222
GLY A 390
 None
 1.01A 2jfaB-6bvdA:
undetectable		 2jfaB-6bvdA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fu4 PROBABLE CHEMOTAXIS
TRANSDUCER

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 101
ASP A 100
LEU A  99
GLY A 148
LEU A 147
 None
 1.08A 2jfaB-6fu4A:
undetectable		 2jfaB-6fu4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A  27
THR A  14
ILE A 164
HIS A 163
 None
 1.14A 2jfaB-1h74A:
0.0		 2jfaB-1h74A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuy CULLIN-3 HOMOLOGUE

(Mus musculus) 		PF10557
(Cullin_Nedd8) 		4 LEU A  78
THR A  89
ILE A  65
HIS A  43
 None
 1.25A 2jfaB-1iuyA:
undetectable		 2jfaB-1iuyA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		4 LEU A 143
THR A 141
ILE A 151
HIS A  99
 None
NAD  A1201 ( 4.1A)
None
None
 1.31A 2jfaB-1kaeA:
0.0		 2jfaB-1kaeA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khy CLPB PROTEIN

(Escherichia
coli) 		PF02861
(Clp_N) 		4 LEU A 122
THR A 121
ILE A  29
HIS A  33
 None
 1.30A 2jfaB-1khyA:
undetectable		 2jfaB-1khyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 LEU A 427
THR A 428
ILE A 318
HIS A 416
 None
 1.42A 2jfaB-1lw3A:
0.0		 2jfaB-1lw3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 152
THR A 148
ILE A 186
HIS A 299
 None
 1.40A 2jfaB-1n8pA:
undetectable		 2jfaB-1n8pA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		4 LEU A  56
THR A  57
ILE A  48
HIS A  41
 None
 1.32A 2jfaB-1o6dA:
undetectable		 2jfaB-1o6dA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		4 LEU A 211
THR A 210
ILE A  36
HIS A 189
 None
None
T5A  A 501 (-4.5A)
None
 1.29A 2jfaB-1p75A:
undetectable		 2jfaB-1p75A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
THR A 347
ILE A 424
HIS A 524
 EST  A   1 (-4.4A)
None
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
 0.82A 2jfaB-1pcgA:
32.8		 2jfaB-1pcgA:
98.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 4 LEU B 206
THR B 196
ILE B  84
HIS B 310
 None
 1.42A 2jfaB-1tahB:
0.0		 2jfaB-1tahB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni) 		PF13580
(SIS_2) 		4 LEU A 180
THR A 179
ILE A 117
HIS A 173
 None
 1.17A 2jfaB-1tk9A:
undetectable		 2jfaB-1tk9A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LEU A 167
THR A  88
ILE A 148
HIS A 143
 None
 1.34A 2jfaB-1u5qA:
undetectable		 2jfaB-1u5qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7h ORNITHINE
CYCLODEAMINASE

(Pseudomonas
putida) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 118
THR A 116
ILE A 197
HIS A 221
 None
 1.32A 2jfaB-1u7hA:
undetectable		 2jfaB-1u7hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 LEU A 847
THR A 845
ILE A 826
HIS A 823
 None
 1.03A 2jfaB-1urjA:
undetectable		 2jfaB-1urjA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		4 LEU A 178
THR A 179
ILE B 270
HIS B 226
 None
 0.76A 2jfaB-1w2wA:
undetectable		 2jfaB-1w2wA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5k NEOGENIN

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A  86
THR A  36
ILE A  56
HIS A  81
 None
 1.06A 2jfaB-1x5kA:
undetectable		 2jfaB-1x5kA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 LEU A   8
THR A   9
ILE A  46
HIS A   5
 None
 1.26A 2jfaB-1xqaA:
undetectable		 2jfaB-1xqaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A 110
THR A 111
ILE A 123
HIS A 134
 None
 1.36A 2jfaB-1y6lA:
undetectable		 2jfaB-1y6lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		4 LEU A 487
THR A 488
ILE A 257
HIS A 395
 None
 1.32A 2jfaB-2eijA:
undetectable		 2jfaB-2eijA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 LEU A 313
THR A 314
ILE A 472
HIS A 471
 TFC  A 600 (-4.2A)
TFC  A 600 ( 4.6A)
None
TFC  A 600 (-4.2A)
 1.26A 2jfaB-2fj0A:
undetectable		 2jfaB-2fj0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 LEU A 447
THR A 263
ILE A 352
HIS A 347
 None
 1.41A 2jfaB-2fwrA:
undetectable		 2jfaB-2fwrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LEU A 167
THR A  88
ILE A 148
HIS A 143
 None
 1.32A 2jfaB-2gcdA:
undetectable		 2jfaB-2gcdA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		4 LEU A  66
THR A  68
ILE A 181
HIS A 200
 None
 1.36A 2jfaB-2gv8A:
undetectable		 2jfaB-2gv8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1) 		4 LEU A 121
THR A 122
ILE A 144
HIS A 145
 None
 1.37A 2jfaB-2l4oA:
undetectable		 2jfaB-2l4oA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn5 HYPOTHETICAL PROTEIN
EF_2215

(Enterococcus
faecalis) 		PF08327
(AHSA1) 		4 LEU A 155
THR A 156
ILE A 147
HIS A 150
 EDO  A 301 ( 4.3A)
None
None
None
 1.22A 2jfaB-2nn5A:
undetectable		 2jfaB-2nn5A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
THR A 347
ILE A 424
HIS A 524
 EST  A 596 (-4.4A)
None
EST  A 596 ( 4.7A)
EST  A 596 (-4.2A)
 0.79A 2jfaB-2ocfA:
31.6		 2jfaB-2ocfA:
91.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot2 HYDROGENASE
ISOENZYMES FORMATION
PROTEIN HYPC

(Escherichia
coli) 		PF01455
(HupF_HypC) 		4 LEU A  71
THR A  67
ILE A   3
HIS A  51
 None
 1.15A 2jfaB-2ot2A:
undetectable		 2jfaB-2ot2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		4 LEU A  35
THR A  36
ILE A  26
HIS A  29
 None
 1.36A 2jfaB-2q14A:
undetectable		 2jfaB-2q14A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9l HYPOTHETICAL PROTEIN

(Vibrio sp.
DAT722) 		PF03819
(MazG) 		4 LEU A  77
THR A  80
ILE A  72
HIS A  73
 None
 1.37A 2jfaB-2q9lA:
undetectable		 2jfaB-2q9lA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 LEU A 640
THR A 641
ILE A 611
HIS A 610
 None
 1.03A 2jfaB-2qvwA:
undetectable		 2jfaB-2qvwA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 LEU G 781
THR G 777
ILE G1082
HIS G1078
 None
 1.31A 2jfaB-2uv8G:
undetectable		 2jfaB-2uv8G:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		4 LEU A 268
THR A 269
ILE A  19
HIS A 404
 None
 1.33A 2jfaB-2z3tA:
undetectable		 2jfaB-2z3tA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 LEU A 144
THR A 143
ILE A 396
HIS A 393
 None
 1.41A 2jfaB-2ztgA:
undetectable		 2jfaB-2ztgA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 ALPHAA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		4 LEU A  63
THR A  64
ILE A  55
HIS A  58
 None
None
None
HEM  A 142 (-4.7A)
 1.26A 2jfaB-3at6A:
undetectable		 2jfaB-3at6A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		4 LEU A 465
THR A 466
ILE A 292
HIS A 300
 None
 1.25A 2jfaB-3danA:
1.9		 2jfaB-3danA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hb7 ISOCHORISMATASE
HYDROLASE

(Alkaliphilus
metalliredigens) 		PF00857
(Isochorismatase) 		4 LEU A 147
THR A 146
ILE A  49
HIS A   4
 None
 1.32A 2jfaB-3hb7A:
undetectable		 2jfaB-3hb7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN REGULATORY
LIGHT CHAIN 2,
SMOOTH MUSCLE MAJOR
ISOFORM

(Gallus gallus) 		PF13405
(EF-hand_6)
PF13833
(EF-hand_8) 		4 LEU B 126
THR B 127
ILE B 117
HIS B 121
 None
 1.40A 2jfaB-3j04B:
undetectable		 2jfaB-3j04B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 LEU C 520
THR C 519
ILE C 551
HIS C 554
 None
 1.40A 2jfaB-3j9uC:
undetectable		 2jfaB-3j9uC:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr2 HEXULOSE-6-PHOSPHATE
SYNTHASE SGBH

(Vibrio cholerae) 		PF00215
(OMPdecase) 		4 LEU A  15
THR A  16
ILE A  32
HIS A  54
 None
 1.35A 2jfaB-3jr2A:
undetectable		 2jfaB-3jr2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 LEU A 375
THR A 374
ILE A 226
HIS A 378
 None
 1.15A 2jfaB-3k9dA:
undetectable		 2jfaB-3k9dA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00926
(DHBP_synthase) 		4 LEU A 181
THR A 178
ILE A  35
HIS A 144
 None
None
None
SO4  A 300 (-4.1A)
 1.20A 2jfaB-3mgzA:
undetectable		 2jfaB-3mgzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt0 UNCHARACTERIZED
PROTEIN PA1789

(Pseudomonas
aeruginosa) 		PF00582
(Usp) 		4 LEU A 169
THR A 168
ILE A 172
HIS A 216
 None
 0.97A 2jfaB-3mt0A:
undetectable		 2jfaB-3mt0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		4 LEU A  76
THR A  72
ILE A  66
HIS A  67
 None
 1.33A 2jfaB-3o8jA:
undetectable		 2jfaB-3o8jA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oes GTPASE RHEBL1

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A  58
THR A  42
ILE A  46
HIS A  55
 None
 1.30A 2jfaB-3oesA:
undetectable		 2jfaB-3oesA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdw UNCHARACTERIZED
HYDROLASE YUTF

(Bacillus
subtilis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A 204
THR A 203
ILE A 258
HIS A 262
 None
None
None
ACY  A 269 (-4.0A)
 1.18A 2jfaB-3pdwA:
undetectable		 2jfaB-3pdwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 LEU A 880
THR A 616
ILE A 607
HIS A 876
 None
 1.39A 2jfaB-3pihA:
undetectable		 2jfaB-3pihA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 LEU A 419
THR A 420
ILE A 348
HIS A 351
 None
 1.36A 2jfaB-3sucA:
undetectable		 2jfaB-3sucA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		4 LEU A 244
THR A 245
ILE A 455
HIS A 242
 None
 1.13A 2jfaB-3t66A:
undetectable		 2jfaB-3t66A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 LEU A  68
THR A  67
ILE A 139
HIS A  61
 None
 1.26A 2jfaB-4ah6A:
undetectable		 2jfaB-4ah6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 LEU A 564
THR A 580
ILE A 458
HIS A 457
 None
 1.22A 2jfaB-4bugA:
1.7		 2jfaB-4bugA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4erv RYANODINE RECEPTOR 3

(Homo sapiens) 		PF02026
(RyR) 		4 LEU A2660
THR A2661
ILE A2654
HIS A2651
 None
None
None
GOL  A2904 (-3.8A)
 1.11A 2jfaB-4ervA:
undetectable		 2jfaB-4ervA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		4 LEU A 584
THR A 585
ILE A  64
HIS A  68
 None
 1.14A 2jfaB-4ex4A:
undetectable		 2jfaB-4ex4A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 LEU A 275
THR A 334
ILE A 268
HIS A 267
 None
 1.23A 2jfaB-4gvlA:
undetectable		 2jfaB-4gvlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA

(Mycobacterium
tuberculosis) 		PF00925
(GTP_cyclohydro2)
PF00926
(DHBP_synthase) 		4 LEU A 181
THR A 178
ILE A  35
HIS A 144
 None
None
None
SO4  A 502 (-4.0A)
 1.27A 2jfaB-4i14A:
undetectable		 2jfaB-4i14A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldc DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA

(Rattus
norvegicus) 		PF00168
(C2) 		4 LEU A 351
THR A 350
ILE A 270
HIS A 399
 None
 1.14A 2jfaB-4ldcA:
undetectable		 2jfaB-4ldcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE

(Thermococcus
onnurineus) 		PF02006
(PPS_PS) 		4 LEU A 249
THR A 247
ILE A  47
HIS A 241
 None
 0.98A 2jfaB-4mb2A:
undetectable		 2jfaB-4mb2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxw LYMPHOTOXIN-BETA

(Homo sapiens) 		no annotation 4 LEU Y 113
THR Y 114
ILE Y  93
HIS Y  91
 None
 1.22A 2jfaB-4mxwY:
undetectable		 2jfaB-4mxwY:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 232
THR A 230
ILE A 346
HIS A 184
 None
 1.39A 2jfaB-4nzsA:
undetectable		 2jfaB-4nzsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo0 MAF-LIKE PROTEIN
BCAL2394

(Burkholderia
cenocepacia) 		PF02545
(Maf) 		4 LEU A 128
THR A  95
ILE A  99
HIS A 125
 None
 1.07A 2jfaB-4oo0A:
undetectable		 2jfaB-4oo0A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oou BETA-1,4-MANNANASE

(Cryptopygus
antarcticus) 		no annotation 4 LEU B 263
THR B 264
ILE B 229
HIS B 230
 None
 0.91A 2jfaB-4oouB:
undetectable		 2jfaB-4oouB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 LEU A 218
THR A 217
ILE A  94
HIS A 221
 None
 1.26A 2jfaB-4ox2A:
undetectable		 2jfaB-4ox2A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmj PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF00248
(Aldo_ket_red) 		4 LEU A 262
THR A 259
ILE A 255
HIS A 216
 None
 1.41A 2jfaB-4pmjA:
undetectable		 2jfaB-4pmjA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaz NUCLEOPROTEIN

(Zaire
ebolavirus) 		PF05505
(Ebola_NP) 		4 LEU A 700
THR A 701
ILE A 734
HIS A 738
 None
 1.16A 2jfaB-4qazA:
undetectable		 2jfaB-4qazA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsx TYPE III EFFECTOR
HOPA1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 LEU A 177
THR A 176
ILE A 268
HIS A 273
 None
 1.25A 2jfaB-4rsxA:
undetectable		 2jfaB-4rsxA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtb CALCIUM UNIPORTER
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 LEU A 101
THR A 100
ILE A 104
HIS A 170
 None
None
None
PG4  A1001 (-3.5A)
 1.22A 2jfaB-4xtbA:
undetectable		 2jfaB-4xtbA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 LEU A 115
THR A 117
ILE A 235
HIS A 238
 None
 1.35A 2jfaB-4yj1A:
undetectable		 2jfaB-4yj1A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 305
THR A 306
ILE A  76
HIS A  99
 None
 1.20A 2jfaB-5a05A:
undetectable		 2jfaB-5a05A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Burkholderia
cenocepacia) 		PF00005
(ABC_tran) 		4 LEU C 229
THR C 233
ILE C 226
HIS C 237
 None
 1.38A 2jfaB-5b57C:
undetectable		 2jfaB-5b57C:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 LEU A 347
THR A 346
ILE A 362
HIS A 350
 None
 1.22A 2jfaB-5bwiA:
undetectable		 2jfaB-5bwiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2h BETA-LACTAMASE

(Mycolicibacterium
smegmatis) 		PF00144
(Beta-lactamase) 		4 LEU A 167
THR A 165
ILE A 155
HIS A 154
 None
 1.14A 2jfaB-5e2hA:
undetectable		 2jfaB-5e2hA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 LEU A 554
THR A 555
ILE A 481
HIS A 475
 None
 1.23A 2jfaB-5f7uA:
undetectable		 2jfaB-5f7uA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 LEU A 470
THR A 469
ILE A 463
HIS A 552
 None
 0.97A 2jfaB-5ficA:
undetectable		 2jfaB-5ficA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fii PHENYLALANINE-4-HYDR
OXYLASE

(Homo sapiens) 		PF01842
(ACT) 		4 LEU A  91
THR A  92
ILE A  38
HIS A 107
 None
 1.05A 2jfaB-5fiiA:
undetectable		 2jfaB-5fiiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		4 LEU H 217
THR H 222
ILE H 314
HIS H 213
 None
 1.10A 2jfaB-5g06H:
undetectable		 2jfaB-5g06H:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4v GLUTAMATE--TRNA
LIGASE

(Xanthomonas
oryzae) 		no annotation 4 LEU A 231
THR A 236
ILE A  17
HIS A  16
 None
 1.33A 2jfaB-5h4vA:
undetectable		 2jfaB-5h4vA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 LEU A 470
THR A 469
ILE A 463
HIS A 552
 None
 1.03A 2jfaB-5hqnA:
undetectable		 2jfaB-5hqnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 LEU A 729
THR A 730
ILE A 557
HIS A 724
 None
 1.04A 2jfaB-5ikzA:
0.9		 2jfaB-5ikzA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9h ENVELOPMENT
POLYPROTEIN

(Puumala
orthohantavirus) 		PF01561
(Hanta_G2) 		4 LEU A1006
THR A1007
ILE A1016
HIS A1056
 None
 1.07A 2jfaB-5j9hA:
undetectable		 2jfaB-5j9hA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5klp ORF34

(Pseudomonas
syringae) 		PF03421
(Acetyltransf_14) 		4 LEU A 246
THR A 245
ILE A 166
HIS A 238
 None
 1.31A 2jfaB-5klpA:
undetectable		 2jfaB-5klpA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljy ENVELOPMENT
POLYPROTEIN

(Hantaan
orthohantavirus) 		PF01561
(Hanta_G2) 		4 LEU A 349
THR A 350
ILE A 359
HIS A 399
 None
 1.25A 2jfaB-5ljyA:
undetectable		 2jfaB-5ljyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 LEU A 458
THR A 457
ILE A 448
HIS A 447
 None
 1.26A 2jfaB-5muxA:
undetectable		 2jfaB-5muxA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9m COBYRIC ACID
SYNTHASE

(Staphylococcus
aureus) 		no annotation 4 LEU A  91
THR A  92
ILE A  20
HIS A   8
 None
 1.37A 2jfaB-5n9mA:
undetectable		 2jfaB-5n9mA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 4 LEU A 264
THR A 263
ILE A 307
HIS A 331
 None
 1.31A 2jfaB-5no5A:
undetectable		 2jfaB-5no5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 LEU A 313
THR A 309
ILE A 279
HIS A 302
 None
 1.31A 2jfaB-5nqdA:
undetectable		 2jfaB-5nqdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oaf RUVB-LIKE 1

(Homo sapiens) 		no annotation 4 LEU A 410
THR A 411
ILE A 377
HIS A  20
 None
None
None
ADP  A 501 (-3.7A)
 1.40A 2jfaB-5oafA:
undetectable		 2jfaB-5oafA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 577
THR A 578
ILE A  64
HIS A  68
 None
 1.20A 2jfaB-5oasA:
undetectable		 2jfaB-5oasA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt RIBOSOMAL PROTEIN
S7, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 LEU Q  54
THR Q  53
ILE Q 173
HIS Q 176
 None
A  E 765 ( 4.9A)
None
None
 1.10A 2jfaB-5optQ:
undetectable		 2jfaB-5optQ:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK

(Candidatus
Pelagibacter
ubique) 		PF07883
(Cupin_2) 		4 LEU A  55
THR A  54
ILE A  90
HIS A  58
 None
None
None
NI  A 201 ( 3.3A)
 1.35A 2jfaB-5tfzA:
undetectable		 2jfaB-5tfzA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 298
THR A 299
ILE A 376
HIS A 475
 EST  A 601 (-4.1A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
 0.71A 2jfaB-5toaA:
29.0		 2jfaB-5toaA:
53.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		4 LEU A 254
THR A 256
ILE A 403
HIS A 404
 None
 1.18A 2jfaB-5uaoA:
undetectable		 2jfaB-5uaoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC

(Medicago
truncatula) 		PF00815
(Histidinol_dh) 		4 LEU A 179
THR A 177
ILE A 187
HIS A 135
 None
 1.32A 2jfaB-5vldA:
undetectable		 2jfaB-5vldA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 LEU A 277
THR A 278
ILE A 255
HIS A 251
 None
 1.29A 2jfaB-5vylA:
undetectable		 2jfaB-5vylA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2b NUCLEOPROTEIN

(Reston
ebolavirus) 		no annotation 4 LEU A 700
THR A 701
ILE A 734
HIS A 738
 None
 1.07A 2jfaB-5w2bA:
undetectable		 2jfaB-5w2bA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3v APOBEC3H

(Macaca
nemestrina) 		no annotation 4 LEU B  80
THR B  81
ILE B  57
HIS B  54
 None
None
None
ZN  B 301 (-3.1A)
 1.32A 2jfaB-5w3vB:
undetectable		 2jfaB-5w3vB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 4 LEU A 320
THR A 323
ILE A 315
HIS A 191
 None
 1.35A 2jfaB-5wa3A:
1.9		 2jfaB-5wa3A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd2 NUDIX FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		4 LEU A 240
THR A 241
ILE A 223
HIS A 220
 None
 1.09A 2jfaB-5xd2A:
undetectable		 2jfaB-5xd2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 4 LEU A  47
THR A  11
ILE A   4
HIS A   8
 None
 1.39A 2jfaB-5z95A:
undetectable		 2jfaB-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		4 LEU A 583
THR A 584
ILE A  64
HIS A  68
 None
 1.20A 2jfaB-6axeA:
undetectable		 2jfaB-6axeA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G

(Pyrococcus
furiosus) 		no annotation 4 LEU B  73
THR B  72
ILE F   8
HIS C  92
 None
 1.14A 2jfaB-6cfwB:
undetectable		 2jfaB-6cfwB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 4 LEU A 152
THR A 151
ILE A 179
HIS A 145
 None
 1.34A 2jfaB-6et7A:
undetectable		 2jfaB-6et7A:
14.91