SIMILAR PATTERNS OF AMINO ACIDS FOR 2JFA_B_CCSB417

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnl PYRIDOXINE
5'-PHOSPHATE OXIDASE

(Escherichia
coli) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 GLN A 146
LYS A 145
VAL A 143
 FMN  A 250 (-3.1A)
None
None
 0.90A 2jfaB-1dnlA:
0.0		 2jfaB-1dnlA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		3 GLN A 176
LYS A 149
VAL A 151
 None
 0.76A 2jfaB-1e5fA:
0.0		 2jfaB-1e5fA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		3 GLN A  56
LYS A  59
VAL A  61
 None
 0.87A 2jfaB-1fd9A:
undetectable		 2jfaB-1fd9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fmm ACIDIC FIBROBLAST
GROWTH FACTOR

(Notophthalmus
viridescens) 		PF00167
(FGF) 		3 GLN S  64
LYS S 108
VAL S  23
 None
 0.93A 2jfaB-1fmmS:
undetectable		 2jfaB-1fmmS:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8) 		PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C) 		3 GLN C 223
LYS C 161
VAL C 163
 None
 0.91A 2jfaB-1g3nC:
1.8		 2jfaB-1g3nC:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		3 GLN A 171
LYS A 146
VAL A 148
 None
 0.89A 2jfaB-1k0fA:
0.0		 2jfaB-1k0fA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7l PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D

(Homo sapiens) 		PF09006
(Surfac_D-trimer) 		3 GLN A  28
LYS A  30
VAL A  32
 None
 0.82A 2jfaB-1m7lA:
undetectable		 2jfaB-1m7lA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 GLN D 422
LYS D 185
VAL D 187
 None
 0.83A 2jfaB-1mhzD:
0.2		 2jfaB-1mhzD:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		3 GLN A 151
LYS A 161
VAL A 164
 None
 0.78A 2jfaB-1mxfA:
0.0		 2jfaB-1mxfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 GLN B  19
LYS B  26
VAL B  28
 None
 0.71A 2jfaB-1n60B:
0.0		 2jfaB-1n60B:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbu PROBABLE
DIHYDRONEOPTERIN
ALDOLASE

(Mycobacterium
tuberculosis) 		PF02152
(FolB) 		3 GLN B 101
LYS B  99
VAL B  30
 None
PH2  B 320 (-3.1A)
None
 0.80A 2jfaB-1nbuB:
0.0		 2jfaB-1nbuB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 GLN B 327
LYS B 291
VAL B 289
 None
 0.93A 2jfaB-1pjmB:
undetectable		 2jfaB-1pjmB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r7l PHAGE PROTEIN

(Bacillus cereus) 		no annotation 3 GLN A  46
LYS A  50
VAL A  48
 None
 0.82A 2jfaB-1r7lA:
undetectable		 2jfaB-1r7lA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz9 REP PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF08724
(Rep_N) 		3 GLN A  73
LYS A  76
VAL A  94
 None
 0.64A 2jfaB-1rz9A:
undetectable		 2jfaB-1rz9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgl TRICHOMAGLIN

(Trichosanthes
lepiniana) 		PF00445
(Ribonuclease_T2) 		3 GLN A  39
LYS A 134
VAL A 132
 None
 0.83A 2jfaB-1sglA:
undetectable		 2jfaB-1sglA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		3 GLN A 131
LYS A 133
VAL A 135
 None
 0.92A 2jfaB-1t6xA:
undetectable		 2jfaB-1t6xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnd TRANSDUCIN

(Bos taurus) 		PF00503
(G-alpha) 		3 GLN A  48
LYS A 329
VAL A 331
 None
 0.81A 2jfaB-1tndA:
undetectable		 2jfaB-1tndA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 444
LYS A 476
VAL A 467
 None
 0.74A 2jfaB-1u59A:
undetectable		 2jfaB-1u59A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 GLN A 257
LYS A 278
VAL A 276
 None
 0.93A 2jfaB-1uxiA:
undetectable		 2jfaB-1uxiA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1win FLOTILLIN 2

(Mus musculus) 		PF01145
(Band_7) 		3 GLN A  62
LYS A  65
VAL A  67
 None
 0.89A 2jfaB-1winA:
undetectable		 2jfaB-1winA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		3 GLN A 236
LYS A 232
VAL A 453
 None
 0.84A 2jfaB-1y3nA:
undetectable		 2jfaB-1y3nA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 GLN A 307
LYS A 309
VAL A 311
 None
 0.56A 2jfaB-1y6jA:
undetectable		 2jfaB-1y6jA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY

(Vibrio cholerae) 		PF01381
(HTH_3) 		3 GLN A  32
LYS A  38
VAL A  36
 None
 0.93A 2jfaB-1y9qA:
undetectable		 2jfaB-1y9qA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yg0 COP ASSOCIATED
PROTEIN

(Helicobacter
pylori) 		PF00403
(HMA) 		3 GLN A  51
LYS A   1
VAL A  43
 None
 0.82A 2jfaB-1yg0A:
undetectable		 2jfaB-1yg0A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqh IG HYPOTHETICAL
16092

(Bacillus cereus) 		PF01910
(Thiamine_BP) 		3 GLN A  32
LYS A  26
VAL A  24
 None
 0.93A 2jfaB-1yqhA:
undetectable		 2jfaB-1yqhA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 GLN C 106
LYS C 217
VAL C 219
 None
 0.92A 2jfaB-1zq1C:
undetectable		 2jfaB-1zq1C:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 GLN A 370
LYS A 188
VAL A 178
 None
 0.83A 2jfaB-2awaA:
undetectable		 2jfaB-2awaA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		3 GLN A  90
LYS A  96
VAL A  98
 None
 0.92A 2jfaB-2canA:
undetectable		 2jfaB-2canA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLN A 252
LYS A 226
VAL A 228
 None
 0.85A 2jfaB-2dfvA:
undetectable		 2jfaB-2dfvA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		3 GLN A 468
LYS A 473
VAL A 465
 None
 0.92A 2jfaB-2exhA:
undetectable		 2jfaB-2exhA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		3 GLN A  50
LYS A  52
VAL A  54
 None
 0.70A 2jfaB-2id0A:
undetectable		 2jfaB-2id0A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		3 GLN A 529
LYS A 561
VAL A 552
 None
 0.87A 2jfaB-2j0jA:
undetectable		 2jfaB-2j0jA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		3 GLN A 529
LYS A 561
VAL A 552
 None
 0.84A 2jfaB-2jkmA:
undetectable		 2jfaB-2jkmA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jp2 SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00568
(WH1) 		3 GLN A  66
LYS A  19
VAL A  43
 None
 0.93A 2jfaB-2jp2A:
undetectable		 2jfaB-2jp2A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jtr PHAGE SHOCK PROTEIN
E

(Escherichia
coli) 		PF00581
(Rhodanese) 		3 GLN A  53
LYS A  27
VAL A  29
 None
 0.93A 2jfaB-2jtrA:
undetectable		 2jfaB-2jtrA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mj2 AGNOPROTEIN

(Human
polyomavirus 2) 		PF01736
(Polyoma_agno) 		3 GLN A  36
LYS A  33
VAL A  30
 None
 0.85A 2jfaB-2mj2A:
undetectable		 2jfaB-2mj2A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLN A  97
LYS A  22
VAL A  20
 None
 0.92A 2jfaB-2obyA:
undetectable		 2jfaB-2obyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		3 GLN A 444
LYS A 476
VAL A 467
 None
 0.74A 2jfaB-2ozoA:
undetectable		 2jfaB-2ozoA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		3 GLN A 598
LYS A 539
VAL A 537
 None
 0.79A 2jfaB-2quqA:
undetectable		 2jfaB-2quqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxy RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg) 		3 GLN A  38
LYS A  35
VAL A  10
 None
 0.82A 2jfaB-2qxyA:
undetectable		 2jfaB-2qxyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 GLN A 117
LYS A 119
VAL A 121
 None
 0.77A 2jfaB-2vl8A:
undetectable		 2jfaB-2vl8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLN A 119
LYS A 156
VAL A 147
 None
 0.91A 2jfaB-2w5hA:
undetectable		 2jfaB-2w5hA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Mus musculus) 		PF00439
(Bromodomain) 		3 GLN A 271
LYS A 264
VAL A 262
 None
 0.85A 2jfaB-2wp1A:
undetectable		 2jfaB-2wp1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLN A 330
LYS A 365
VAL A 353
 None
 0.74A 2jfaB-2xk9A:
undetectable		 2jfaB-2xk9A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 GLN A 350
LYS A 382
VAL A 373
 None
 0.83A 2jfaB-2zv7A:
undetectable		 2jfaB-2zv7A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLN A 124
LYS A 159
VAL A 147
 None
 0.63A 2jfaB-3c0iA:
undetectable		 2jfaB-3c0iA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		3 GLN A  68
LYS A  70
VAL A  72
 None
 0.84A 2jfaB-3c7kA:
undetectable		 2jfaB-3c7kA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		3 GLN A 132
LYS A 167
VAL A 157
 None
 0.59A 2jfaB-3e3pA:
undetectable		 2jfaB-3e3pA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 GLN A 255
LYS A 235
VAL A 237
 None
 0.89A 2jfaB-3hwwA:
undetectable		 2jfaB-3hwwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1

(Vitis vinifera) 		PF05368
(NmrA) 		3 GLN A  72
LYS A 107
VAL A 109
 None
 0.89A 2jfaB-3i5mA:
undetectable		 2jfaB-3i5mA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		3 GLN A 330
LYS A 365
VAL A 353
 None
 0.52A 2jfaB-3i6uA:
undetectable		 2jfaB-3i6uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLN A  18
LYS A  89
VAL A  91
 None
 0.92A 2jfaB-3ifeA:
undetectable		 2jfaB-3ifeA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		3 GLN A 271
LYS A 272
VAL A 274
 None
 0.84A 2jfaB-3ifqA:
undetectable		 2jfaB-3ifqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		3 GLN A 360
LYS A 299
VAL A 339
 None
AKG  A 702 (-3.6A)
None
 0.88A 2jfaB-3kv6A:
undetectable		 2jfaB-3kv6A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		3 GLN A  69
LYS A  85
VAL A  83
 None
 0.88A 2jfaB-3l8aA:
undetectable		 2jfaB-3l8aA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyb PUTATIVE
ENDORIBONUCLEASE

(Klebsiella
pneumoniae) 		PF01042
(Ribonuc_L-PSP) 		3 GLN A  99
LYS A  96
VAL A  94
 None
 0.92A 2jfaB-3lybA:
undetectable		 2jfaB-3lybA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 796
LYS A 828
VAL A 819
 None
 0.78A 2jfaB-3lzbA:
undetectable		 2jfaB-3lzbA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqc BONE MARROW STROMAL
ANTIGEN 2

(Homo sapiens) 		PF16716
(BST2) 		3 GLN A  68
LYS A  71
VAL A  73
 None
 0.90A 2jfaB-3mqcA:
undetectable		 2jfaB-3mqcA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sks PUTATIVE
OLIGOENDOPEPTIDASE F

(Bacillus
anthracis) 		no annotation 3 GLN A 239
LYS A 546
VAL A 548
 None
 0.83A 2jfaB-3sksA:
undetectable		 2jfaB-3sksA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		3 GLN A 242
LYS A 250
VAL A 269
 None
 0.90A 2jfaB-3tehA:
undetectable		 2jfaB-3tehA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
PANCREATIC

(Mus musculus) 		PF00074
(RnaseA) 		3 GLN A  61
LYS A  75
VAL A 109
 None
 0.92A 2jfaB-3tsrA:
undetectable		 2jfaB-3tsrA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		3 GLN A  18
LYS A  20
VAL A  22
 None
 0.93A 2jfaB-3tviA:
undetectable		 2jfaB-3tviA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1x PUTATIVE GLYCOSYL
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		3 GLN A 104
LYS A 192
VAL A 196
 None
 0.87A 2jfaB-3u1xA:
undetectable		 2jfaB-3u1xA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 3 GLN A  61
LYS A  64
VAL A   5
 None
 0.92A 2jfaB-3wevA:
undetectable		 2jfaB-3wevA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0f CD81 ANTIGEN

(Mus musculus) 		no annotation 3 GLN A 133
LYS A 144
VAL A 146
 None
 0.89A 2jfaB-3x0fA:
undetectable		 2jfaB-3x0fA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		3 GLN A 282
LYS A 284
VAL A 286
 None
 0.89A 2jfaB-4c1sA:
undetectable		 2jfaB-4c1sA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 GLN A 906
LYS A 910
VAL A 908
 None
 0.82A 2jfaB-4c3hA:
undetectable		 2jfaB-4c3hA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus) 		PF00973
(Paramyxo_ncap) 		3 GLN A 200
LYS A 201
VAL A 203
 None
 0.92A 2jfaB-4co6A:
undetectable		 2jfaB-4co6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 477
LYS A 509
VAL A 500
 None
 0.73A 2jfaB-4f4pA:
undetectable		 2jfaB-4f4pA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 GLN B 771
LYS B 818
VAL B 816
 None
 0.89A 2jfaB-4fhnB:
undetectable		 2jfaB-4fhnB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 GLN A 646
LYS A 621
VAL A 661
 None
 0.91A 2jfaB-4fn5A:
undetectable		 2jfaB-4fn5A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7y DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 3 GLN A 118
LYS A 112
VAL A 110
 None
 0.92A 2jfaB-4h7yA:
undetectable		 2jfaB-4h7yA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 GLN A 226
LYS A 248
VAL A 250
 EDO  A 603 (-2.8A)
None
None
 0.81A 2jfaB-4mruA:
undetectable		 2jfaB-4mruA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		3 GLN A 293
LYS A 296
VAL A 298
 None
 0.90A 2jfaB-4nz6A:
undetectable		 2jfaB-4nz6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A1006
LYS A1038
VAL A1029
 None
 0.79A 2jfaB-4oliA:
undetectable		 2jfaB-4oliA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 GLN A 172
LYS A 295
VAL A 297
 None
 0.76A 2jfaB-4ovdA:
undetectable		 2jfaB-4ovdA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9a POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		3 GLN A 365
LYS A 339
VAL A 341
 None
 0.65A 2jfaB-4p9aA:
undetectable		 2jfaB-4p9aA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pa1 INTEGRASE

(Feline
immunodeficiency
virus) 		PF00665
(rve) 		3 GLN A  89
LYS A 101
VAL A 103
 None
 0.86A 2jfaB-4pa1A:
undetectable		 2jfaB-4pa1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		3 GLN A 124
LYS A 156
VAL A 147
 None
 0.81A 2jfaB-4rewA:
undetectable		 2jfaB-4rewA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 GLN B 218
LYS B 181
VAL B 179
 None
 0.88A 2jfaB-4trqB:
undetectable		 2jfaB-4trqB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3w 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 GLN A 445
LYS A 418
VAL A 420
 None
 0.92A 2jfaB-4u3wA:
undetectable		 2jfaB-4u3wA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SOXY PROTEIN

(Thermus
thermophilus) 		PF13501
(SoxY) 		3 GLN B  41
LYS B  44
VAL B  46
 None
 0.90A 2jfaB-4uwqB:
undetectable		 2jfaB-4uwqB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		3 GLN A 337
LYS A 181
VAL A 183
 None
 0.86A 2jfaB-4xaiA:
12.0		 2jfaB-4xaiA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Saccharomyces
cerevisiae) 		no annotation 3 GLN L 408
LYS L 442
VAL L 432
 None
 0.67A 2jfaB-4xr7L:
undetectable		 2jfaB-4xr7L:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		3 GLN A 336
LYS A 340
VAL A 342
 None
 0.91A 2jfaB-4xvgA:
undetectable		 2jfaB-4xvgA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 3 GLN A 170
LYS A 172
VAL A 176
 EDO  A 804 (-4.1A)
None
EDO  A 808 ( 3.6A)
 0.75A 2jfaB-4y9vA:
undetectable		 2jfaB-4y9vA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 GLN A1250
LYS A 929
VAL A 931
 None
 0.84A 2jfaB-4zktA:
undetectable		 2jfaB-4zktA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		3 GLN A1591
LYS A1594
VAL A1596
 None
 0.89A 2jfaB-5cwvA:
undetectable		 2jfaB-5cwvA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A1006
LYS A1038
VAL A1029
 None
 0.76A 2jfaB-5f1zA:
undetectable		 2jfaB-5f1zA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 820
LYS A 852
VAL A 843
 None
 0.83A 2jfaB-5j9zA:
undetectable		 2jfaB-5j9zA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		3 GLN A 259
LYS A 137
VAL A 139
 None
 0.92A 2jfaB-5jlcA:
1.9		 2jfaB-5jlcA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 GLN A 210
LYS A 213
VAL A 215
 None
 0.57A 2jfaB-5t8tA:
undetectable		 2jfaB-5t8tA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcx CD81 ANTIGEN

(Homo sapiens) 		PF00335
(Tetraspannin) 		3 GLN A 133
LYS A 144
VAL A 146
 None
 0.71A 2jfaB-5tcxA:
undetectable		 2jfaB-5tcxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 3 GLN A 786
LYS A 819
VAL A 809
 None
 0.65A 2jfaB-5vilA:
undetectable		 2jfaB-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6f FLAGELLAR BRAKE
PROTEIN YCGR

(Escherichia
coli) 		no annotation 3 GLN A  90
LYS A  67
VAL A  65
 None
 0.74A 2jfaB-5y6fA:
undetectable		 2jfaB-5y6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		no annotation 3 GLN A 122
LYS A 155
VAL A 145
 None
 0.66A 2jfaB-5yksA:
undetectable		 2jfaB-5yksA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN

(Escherichia
coli) 		no annotation 3 GLN A 336
LYS A 180
VAL A 182
 None
 0.91A 2jfaB-5z0rA:
undetectable		 2jfaB-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 3 GLN A 388
LYS A 399
VAL A 397
 None
 0.93A 2jfaB-6b82A:
undetectable		 2jfaB-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 3 GLN A 986
LYS A1018
VAL A1009
 None
 0.65A 2jfaB-6c7yA:
undetectable		 2jfaB-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gt1 SERINE/THREONINE-PRO
TEIN KINASE NEK7

(Homo sapiens) 		no annotation 3 GLN A 144
LYS A 176
VAL A 167
 None
 0.88A 2jfaB-6gt1A:
undetectable		 2jfaB-6gt1A:
undetectable