SIMILAR PATTERNS OF AMINO ACIDS FOR 2JFA_A_RALA600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0f GLUTATHIONE
S-TRANSFERASE

(Escherichia
coli) 		PF00043
(GST_C)
PF13409
(GST_N_2) 		5 ALA A 194
GLU A 198
LEU A 195
LEU A  12
ILE A 153
 None
 1.11A 2jfaA-1a0fA:
undetectable		 2jfaA-1a0fA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 THR A  75
ALA A  79
LEU A  80
LEU A 107
ILE A 179
 None
 1.11A 2jfaA-1ayeA:
undetectable		 2jfaA-1ayeA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 GLU A  49
LEU A  48
LEU A 301
ARG A 335
ILE A 290
 None
 1.05A 2jfaA-1cj2A:
undetectable		 2jfaA-1cj2A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		6 ALA A  88
GLU A  87
LEU A  83
LEU A  82
ILE A 253
LEU A 285
 None
 1.41A 2jfaA-1csjA:
undetectable		 2jfaA-1csjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		6 ALA A  88
GLU A  87
LEU A  91
LEU A  83
LEU A  82
ILE A 253
 None
 1.37A 2jfaA-1csjA:
undetectable		 2jfaA-1csjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd CARBOXYPEPTIDASE A2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 THR A 430
ALA A 434
LEU A 435
LEU A 462
ILE A 535
 None
 1.12A 2jfaA-1dtdA:
undetectable		 2jfaA-1dtdA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		6 THR A  97
ALA A  92
GLU A  93
LEU A  91
ARG A 301
ILE A 261
 None
 1.39A 2jfaA-1fhuA:
undetectable		 2jfaA-1fhuA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 THR A 179
ALA A 567
LEU A 565
TRP A 595
LEU A 574
 None
 1.08A 2jfaA-1g8kA:
undetectable		 2jfaA-1g8kA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C) 		5 MET A 211
THR E 955
LEU E1001
TRP E 908
LEU E 903
 None
 1.12A 2jfaA-1o7dA:
undetectable		 2jfaA-1o7dA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og0 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Saccharomyces
cerevisiae) 		PF00793
(DAHP_synth_1) 		5 ALA A  84
LEU A  81
LEU A 148
LEU A 153
ILE A  72
 None
 0.98A 2jfaA-1og0A:
undetectable		 2jfaA-1og0A:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
ILE A 424
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.6A)
 0.74A 2jfaA-1pcgA:
34.1		 2jfaA-1pcgA:
98.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
THR A 347
ALA A 350
GLU A 353
LEU A 354
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
 EST  A   1 ( 4.0A)
None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.58A 2jfaA-1pcgA:
34.1		 2jfaA-1pcgA:
98.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
LEU A 525
 EST  A   1 ( 4.0A)
None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 (-3.6A)
 0.68A 2jfaA-1pcgA:
34.1		 2jfaA-1pcgA:
98.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 TRP A 286
LEU A 290
ARG A 297
ILE A 344
LEU A 435
 None
EPH  A4000 ( 4.8A)
None
EPH  A4000 ( 4.1A)
EPH  A4000 ( 4.6A)
 0.80A 2jfaA-1r20A:
21.6		 2jfaA-1r20A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		6 ALA A 231
GLU A 230
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.11A 2jfaA-1sgvA:
undetectable		 2jfaA-1sgvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		6 ALA A 231
GLU A 230
LEU A 234
LEU A 226
LEU A 224
LEU A  63
 None
 1.15A 2jfaA-1sgvA:
undetectable		 2jfaA-1sgvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 343
LEU A 347
TRP A 376
LEU A 380
ARG A 387
ILE A 416
 MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
None
 0.99A 2jfaA-1uhlA:
22.8		 2jfaA-1uhlA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 343
LEU A 347
TRP A 376
LEU A 380
ARG A 387
ILE A 499
 MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
None
 1.12A 2jfaA-1uhlA:
22.8		 2jfaA-1uhlA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 343
TRP A 376
LEU A 380
ARG A 387
ILE A 416
LEU A 507
 MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
None
MEI  A1001 (-4.6A)
 0.93A 2jfaA-1uhlA:
22.8		 2jfaA-1uhlA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		6 ALA A 246
LEU A 250
TRP A 279
LEU A 283
ARG A 290
ILE A 402
 9CR  A 201 (-3.6A)
None
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-2.8A)
None
 1.04A 2jfaA-1xiuA:
23.3		 2jfaA-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 ALA A 246
LEU A 250
TRP A 279
LEU A 283
ILE A 319
 9CR  A 201 (-3.6A)
None
None
9CR  A 201 ( 4.1A)
None
 1.02A 2jfaA-1xiuA:
23.3		 2jfaA-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 ALA A 246
TRP A 279
LEU A 283
ARG A 290
LEU A 410
 9CR  A 201 (-3.6A)
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-2.8A)
9CR  A 201 ( 4.8A)
 0.83A 2jfaA-1xiuA:
23.3		 2jfaA-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 ALA A 246
TRP A 279
LEU A 283
ILE A 319
LEU A 410
 9CR  A 201 (-3.6A)
None
9CR  A 201 ( 4.1A)
None
9CR  A 201 ( 4.8A)
 0.89A 2jfaA-1xiuA:
23.3		 2jfaA-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
LEU A 276
TRP A 305
ARG A 316
ILE A 345
 9CR  A 801 (-3.5A)
None
None
9CR  A 801 (-2.6A)
9CR  A 801 ( 4.5A)
 0.99A 2jfaA-1xlsA:
22.6		 2jfaA-1xlsA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
TRP A 305
ARG A 316
ILE A 345
LEU A 436
 9CR  A 801 (-3.5A)
None
9CR  A 801 (-2.6A)
9CR  A 801 ( 4.5A)
9CR  A 801 (-4.7A)
 0.91A 2jfaA-1xlsA:
22.6		 2jfaA-1xlsA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A 801 (-3.5A)
None
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.7A)
 0.86A 2jfaA-1xlsA:
22.6		 2jfaA-1xlsA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT

(Pyrococcus
abyssi) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		5 THR A  18
ALA A  17
LEU A  80
LEU A  82
ILE A  54
 None
 0.98A 2jfaA-1yz6A:
undetectable		 2jfaA-1yz6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zel HYPOTHETICAL PROTEIN
RV2827C

(Mycobacterium
tuberculosis) 		PF09407
(AbiEi_1)
PF13338
(AbiEi_4) 		5 THR A 189
ALA A 188
LEU A 234
LEU A 207
LEU A 220
 FMT  A 707 ( 4.6A)
None
None
None
None
 1.11A 2jfaA-1zelA:
undetectable		 2jfaA-1zelA:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 272
GLU A 275
LEU A 276
TRP A 305
LEU A 309
ARG A 316
 OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 (-4.9A)
None
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
 0.61A 2jfaA-2gpvA:
27.0		 2jfaA-2gpvA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
ARG A 394
ILE A 424
LEU A 525
 EST  A 596 (-4.8A)
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-3.6A)
 0.80A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
ARG A 394
MET A 421
LEU A 525
 EST  A 596 (-4.8A)
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 (-3.6A)
 0.80A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
ILE A 424
 EST  A 596 (-4.8A)
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
 0.58A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
 EST  A 596 (-4.8A)
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.51A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
THR A 347
GLU A 353
LEU A 354
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
 EST  A 596 (-4.8A)
None
EST  A 596 (-2.7A)
None
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.68A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		5 THR A1074
ALA A1077
GLU A1080
LEU A1081
LEU A1009
 None
 0.88A 2jfaA-2oxfA:
undetectable		 2jfaA-2oxfA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ALA A  36
TRP A  69
LEU A  77
ARG A  80
MET A 108
 1CA  A 247 (-3.6A)
None
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.64A 2jfaA-2q3yA:
25.1		 2jfaA-2q3yA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 THR A 193
ALA A 196
LEU A 200
LEU A 210
LEU A 102
 None
 0.90A 2jfaA-2vqrA:
undetectable		 2jfaA-2vqrA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 THR A 193
ALA A 196
LEU A 200
LEU A 210
LEU A 301
 None
 1.08A 2jfaA-2vqrA:
undetectable		 2jfaA-2vqrA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 THR A 193
ALA A 196
LEU A 200
LEU A 210
LEU A 102
 None
 0.84A 2jfaA-2w8sA:
undetectable		 2jfaA-2w8sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wch GENERAL
ODORANT-BINDING
PROTEIN 1

(Bombyx mori) 		PF01395
(PBP_GOBP) 		5 MET A   5
LEU A  16
LEU A  61
MET A  90
ILE A  94
 None
None
B7M  A1145 ( 4.7A)
None
B7M  A1145 ( 4.5A)
 1.01A 2jfaA-2wchA:
undetectable		 2jfaA-2wchA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wch GENERAL
ODORANT-BINDING
PROTEIN 1

(Bombyx mori) 		PF01395
(PBP_GOBP) 		5 MET A   5
THR A   9
LEU A  16
LEU A  61
MET A  90
 None
B7M  A1145 ( 4.1A)
None
B7M  A1145 ( 4.7A)
None
 1.01A 2jfaA-2wchA:
undetectable		 2jfaA-2wchA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5v MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88

(Homo sapiens) 		PF01582
(TIR) 		5 THR A  90
ALA A  93
LEU A 105
ILE A 108
LEU A 121
 None
 1.05A 2jfaA-2z5vA:
undetectable		 2jfaA-2z5vA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet RAS-RELATED PROTEIN
RAB-27B

(Mus musculus) 		PF00071
(Ras) 		5 ALA A  14
LEU A  15
LEU A  13
ILE A  10
LEU A 177
 None
 1.11A 2jfaA-2zetA:
undetectable		 2jfaA-2zetA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		5 ALA A  14
LEU A  15
LEU A  13
ILE A  10
LEU A 177
 None
 1.11A 2jfaA-3bc1A:
undetectable		 2jfaA-3bc1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 ALA A 347
GLU A 346
LEU A 350
LEU A 342
ARG A 339
ILE A 415
 None
 1.29A 2jfaA-3cgdA:
undetectable		 2jfaA-3cgdA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 THR A 319
GLU A 484
LEU A 487
LEU A 314
ILE A 213
 None
 1.05A 2jfaA-3dmyA:
undetectable		 2jfaA-3dmyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 ALA A 272
LEU A 276
TRP A 305
ILE A 345
LEU A 436
 9CR  A7223 (-4.2A)
None
None
9CR  A7223 ( 4.9A)
9CR  A7223 ( 4.7A)
 0.85A 2jfaA-3dzuA:
22.7		 2jfaA-3dzuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
ILE A 428
 9CR  A7223 (-4.2A)
None
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
None
 1.02A 2jfaA-3dzuA:
22.7		 2jfaA-3dzuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A7223 (-4.2A)
None
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
9CR  A7223 ( 4.7A)
 0.87A 2jfaA-3dzuA:
22.7		 2jfaA-3dzuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD

(Arthrobacter
sp. FB24) 		PF13794
(MiaE_2) 		5 ALA A  23
GLU A  26
LEU A  27
LEU A  62
MET A  70
 None
UNL  A 500 (-3.5A)
None
None
None
 1.10A 2jfaA-3ez0A:
undetectable		 2jfaA-3ez0A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7c PROTEIN OF UNKNOWN
FUNCTION (DUF416)

(Marinobacter
hydrocarbonoclasticus) 		PF04222
(DUF416) 		5 ALA A  26
GLU A  27
LEU A  23
LEU A  52
LEU A  75
 None
 1.13A 2jfaA-3f7cA:
undetectable		 2jfaA-3f7cA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF00392
(GntR)
PF07729
(FCD) 		5 THR A  72
GLU A  30
LEU A  32
LEU A  26
LEU A 159
 None
 1.08A 2jfaA-3fmsA:
undetectable		 2jfaA-3fmsA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY

(Strongyloides
stercoralis) 		PF00104
(Hormone_recep) 		5 MET A 569
LEU A 522
LEU A 657
ILE A 598
LEU A 664
 None
 1.11A 2jfaA-3gyuA:
19.5		 2jfaA-3gyuA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0y PUTATIVE POLYKETIDE
CYCLASE

(Xanthomonas
campestris) 		PF12680
(SnoaL_2) 		5 THR A 122
ALA A  33
GLU A  34
LEU A  29
LEU A  12
 None
 1.10A 2jfaA-3i0yA:
undetectable		 2jfaA-3i0yA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 MET A 533
THR A 537
ALA A 540
ILE A 397
LEU A 393
 None
 1.05A 2jfaA-3lppA:
undetectable		 2jfaA-3lppA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a DIHEME CYTOCHROME C
NAPB
PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF03892
(NapB)
PF04879
(Molybdop_Fe4S4) 		5 THR B  10
LEU A 491
ARG A  76
MET A 465
LEU A 774
 None
FMT  B 139 (-4.5A)
None
None
CL  A 816 (-4.0A)
 1.13A 2jfaA-3o5aB:
undetectable		 2jfaA-3o5aB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 MET A 499
ALA A 334
LEU A 335
LEU A 488
ILE A 305
 None
 1.02A 2jfaA-3qfkA:
undetectable		 2jfaA-3qfkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp6 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		5 THR A 175
ALA A 143
LEU A 104
ILE A 185
LEU A  58
 None
 1.04A 2jfaA-3qp6A:
undetectable		 2jfaA-3qp6A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp8 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF03472
(Autoind_bind) 		5 THR A 175
ALA A 143
LEU A 104
ILE A 185
LEU A  58
 None
 1.08A 2jfaA-3qp8A:
undetectable		 2jfaA-3qp8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 THR A 199
ALA A 198
LEU A 390
LEU A 175
ILE A  37
 None
 1.12A 2jfaA-3r75A:
undetectable		 2jfaA-3r75A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		6 ALA A 297
GLU A 300
LEU A 298
LEU A 107
ARG A 132
ILE A 203
 None
 1.42A 2jfaA-3wwxA:
undetectable		 2jfaA-3wwxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 THR B 306
ALA B 309
LEU A  67
LEU A  74
MET B 430
 None
None
None
None
S35  A1259 ( 4.6A)
 1.08A 2jfaA-4az3B:
undetectable		 2jfaA-4az3B:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		5 THR A  74
ALA A  73
LEU A   7
LEU A  69
MET A  52
 None
 1.10A 2jfaA-4dimA:
undetectable		 2jfaA-4dimA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 ALA A 406
GLU A 374
LEU A 415
ILE A 452
LEU A 434
 None
 1.07A 2jfaA-4fqdA:
undetectable		 2jfaA-4fqdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8n CONJUGATED
POLYKETONE REDUCTASE
C2

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		5 THR A 242
ALA A 236
GLU A 237
LEU A 235
LEU A 220
 None
None
None
None
NDP  A3001 ( 4.2A)
 1.11A 2jfaA-4h8nA:
undetectable		 2jfaA-4h8nA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		5 THR A 295
ALA A 298
GLU A 301
LEU A 302
LEU A 334
 None
 0.83A 2jfaA-4ix3A:
undetectable		 2jfaA-4ix3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 6 ALA D 272
LEU D 276
TRP D 305
LEU D 309
ARG D 316
ILE D 345
 None
 0.96A 2jfaA-4j5xD:
21.6		 2jfaA-4j5xD:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 6 ALA D 272
LEU D 276
TRP D 305
LEU D 309
ARG D 316
ILE D 428
 None
 1.08A 2jfaA-4j5xD:
21.6		 2jfaA-4j5xD:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 6 ALA D 272
TRP D 305
LEU D 309
ARG D 316
ILE D 345
LEU D 436
 None
 0.90A 2jfaA-4j5xD:
21.6		 2jfaA-4j5xD:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 THR A 306
ALA A 309
LEU A  67
LEU A  74
MET A 430
 THR  A 306 ( 0.8A)
ALA  A 309 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  74 ( 0.6A)
MET  A 430 ( 0.0A)
 1.11A 2jfaA-4mwtA:
undetectable		 2jfaA-4mwtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		6 THR A  41
ALA A  40
TRP A 255
LEU A 210
LEU A 213
ILE A  27
 None
 1.20A 2jfaA-4mwzA:
undetectable		 2jfaA-4mwzA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 ALA A 287
GLU A 290
LEU A 291
TRP A 320
LEU A 324
ARG A 331
 None
 0.42A 2jfaA-4n1yA:
27.5		 2jfaA-4n1yA:
35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 ALA A 287
GLU A 290
LEU A 324
ARG A 331
MET A 358
 None
 0.80A 2jfaA-4n1yA:
27.5		 2jfaA-4n1yA:
35.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		5 THR A  71
ALA A  74
GLU A  77
LEU A  78
LEU A   6
 None
 0.86A 2jfaA-4r2wA:
undetectable		 2jfaA-4r2wA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		6 ALA A 131
LEU A 134
LEU A  48
LEU A 124
ILE A  64
LEU A  45
 None
 1.44A 2jfaA-4rgyA:
undetectable		 2jfaA-4rgyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 773
TRP A 806
LEU A 810
LEU A 814
ARG A 817
 CV7  A1987 (-3.5A)
None
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
 0.52A 2jfaA-4udbA:
24.8		 2jfaA-4udbA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		5 THR A 123
ALA A 126
GLU A 129
ILE A  82
LEU A  16
 None
 1.03A 2jfaA-4wh0A:
undetectable		 2jfaA-4wh0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 563
TRP A 348
LEU A 421
LEU A 422
MET A 368
 None
 1.11A 2jfaA-4wziA:
3.2		 2jfaA-4wziA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN

(Homo sapiens) 		PF00975
(Thioesterase) 		5 ALA A 111
GLU A 121
LEU A 112
LEU A 200
LEU A 127
 None
 1.12A 2jfaA-4xjvA:
undetectable		 2jfaA-4xjvA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		5 ALA A 485
LEU A 482
LEU A 524
LEU A 521
ILE A 516
 None
 1.11A 2jfaA-5a29A:
undetectable		 2jfaA-5a29A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 THR A 206
ALA A 209
GLU A 212
LEU A 213
ILE A 186
 None
 0.71A 2jfaA-5allA:
undetectable		 2jfaA-5allA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 THR A 206
ALA A 209
GLU A 212
LEU A 213
LEU A 202
 None
 0.82A 2jfaA-5allA:
undetectable		 2jfaA-5allA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Mus musculus) 		PF12777
(MT) 		5 ALA A3394
LEU A3398
LEU A3325
LEU A3326
ILE A3336
 None
 0.99A 2jfaA-5ayhA:
undetectable		 2jfaA-5ayhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkm AT5G51070/K3K7_27

(Arabidopsis
thaliana) 		PF02861
(Clp_N) 		5 THR A 223
ALA A 197
LEU A 115
ARG A  86
LEU A 212
 None
 1.06A 2jfaA-5gkmA:
undetectable		 2jfaA-5gkmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 THR A 353
ALA A 283
LEU A 282
LEU A  38
ILE A 380
 None
 1.05A 2jfaA-5gmxA:
undetectable		 2jfaA-5gmxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 THR A 211
ALA A 214
GLU A 217
ARG A  95
LEU A 195
 None
 0.90A 2jfaA-5iq0A:
undetectable		 2jfaA-5iq0A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 ALA A 285
GLU A 286
LEU A 287
ARG A 318
ILE A 165
 None
 1.07A 2jfaA-5jd5A:
undetectable		 2jfaA-5jd5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqw 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		5 THR A  92
ALA A  94
GLU A  97
LEU A  98
LEU A 337
 None
 1.04A 2jfaA-5kqwA:
undetectable		 2jfaA-5kqwA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 THR A  73
ALA A  76
GLU A  79
LEU A  80
LEU A   8
 None
 0.81A 2jfaA-5lhvA:
undetectable		 2jfaA-5lhvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 5 LEU A 559
TRP A 490
LEU A 482
ILE A 543
LEU A 507
 None
 1.12A 2jfaA-5oatA:
undetectable		 2jfaA-5oatA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 ALA A 563
TRP A 348
LEU A 421
LEU A 422
MET A 368
 None
 1.10A 2jfaA-5ohjA:
2.1		 2jfaA-5ohjA:
15.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 294
GLU A 305
LEU A 343
ARG A 346
ILE A 376
 None
EST  A 601 (-2.4A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
 1.12A 2jfaA-5toaA:
30.1		 2jfaA-5toaA:
53.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 295
THR A 299
ALA A 302
GLU A 305
TRP A 335
LEU A 339
LEU A 343
ARG A 346
ILE A 376
LEU A 476
 EST  A 601 ( 4.4A)
None
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-3.5A)
 0.75A 2jfaA-5toaA:
30.1		 2jfaA-5toaA:
53.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 295
THR A 299
GLU A 305
LEU A 306
TRP A 335
LEU A 339
LEU A 343
ARG A 346
ILE A 376
LEU A 476
 EST  A 601 ( 4.4A)
None
EST  A 601 (-2.4A)
None
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-3.5A)
 0.85A 2jfaA-5toaA:
30.1		 2jfaA-5toaA:
53.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 6 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
ILE A 428
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
 1.20A 2jfaA-5uanA:
22.4		 2jfaA-5uanA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 5 ALA A 272
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
9CR  A 503 ( 4.8A)
 1.03A 2jfaA-5uanA:
22.4		 2jfaA-5uanA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 5 ALA A 117
LEU A 102
LEU A  94
LEU A  95
LEU A  70
 None
 1.03A 2jfaA-5wbfA:
undetectable		 2jfaA-5wbfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkt UREASE ACCESSORY
PROTEIN UREG

(Klebsiella
pneumoniae) 		no annotation 5 GLU A 104
LEU A  24
LEU A  23
ILE A 194
LEU A 100
 NI  A 302 ( 2.5A)
None
None
None
None
 1.09A 2jfaA-5xktA:
undetectable		 2jfaA-5xktA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 5 ALA A 174
LEU A 171
LEU A 105
LEU A 104
LEU A 112
 None
 1.07A 2jfaA-5xxgA:
undetectable		 2jfaA-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 GLU A  49
LEU A  48
LEU A 301
ARG A 335
ILE A 290
 CL  A 402 ( 4.6A)
None
CL  A 402 (-4.8A)
CL  A 402 (-3.5A)
None
 1.11A 2jfaA-6dllA:
undetectable		 2jfaA-6dllA:
19.46