SIMILAR PATTERNS OF AMINO ACIDS FOR 2JFA_A_RALA600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0f GLUTATHIONE
S-TRANSFERASE

(Escherichia
coli) 		PF00043
(GST_C)
PF13409
(GST_N_2) 		5 ALA A 194
GLU A 198
LEU A 195
LEU A  12
ILE A 153
 None
 1.11A 2jfaA-1a0fA:
undetectable		 2jfaA-1a0fA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 THR A  75
ALA A  79
LEU A  80
LEU A 107
ILE A 179
 None
 1.11A 2jfaA-1ayeA:
undetectable		 2jfaA-1ayeA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 GLU A  49
LEU A  48
LEU A 301
ARG A 335
ILE A 290
 None
 1.05A 2jfaA-1cj2A:
undetectable		 2jfaA-1cj2A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		6 ALA A  88
GLU A  87
LEU A  83
LEU A  82
ILE A 253
LEU A 285
 None
 1.41A 2jfaA-1csjA:
undetectable		 2jfaA-1csjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		6 ALA A  88
GLU A  87
LEU A  91
LEU A  83
LEU A  82
ILE A 253
 None
 1.37A 2jfaA-1csjA:
undetectable		 2jfaA-1csjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd CARBOXYPEPTIDASE A2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 THR A 430
ALA A 434
LEU A 435
LEU A 462
ILE A 535
 None
 1.12A 2jfaA-1dtdA:
undetectable		 2jfaA-1dtdA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		6 THR A  97
ALA A  92
GLU A  93
LEU A  91
ARG A 301
ILE A 261
 None
 1.39A 2jfaA-1fhuA:
undetectable		 2jfaA-1fhuA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 THR A 179
ALA A 567
LEU A 565
TRP A 595
LEU A 574
 None
 1.08A 2jfaA-1g8kA:
undetectable		 2jfaA-1g8kA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C) 		5 MET A 211
THR E 955
LEU E1001
TRP E 908
LEU E 903
 None
 1.12A 2jfaA-1o7dA:
undetectable		 2jfaA-1o7dA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og0 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Saccharomyces
cerevisiae) 		PF00793
(DAHP_synth_1) 		5 ALA A  84
LEU A  81
LEU A 148
LEU A 153
ILE A  72
 None
 0.98A 2jfaA-1og0A:
undetectable		 2jfaA-1og0A:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
ILE A 424
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.6A)
 0.74A 2jfaA-1pcgA:
34.1		 2jfaA-1pcgA:
98.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
THR A 347
ALA A 350
GLU A 353
LEU A 354
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
 EST  A   1 ( 4.0A)
None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.58A 2jfaA-1pcgA:
34.1		 2jfaA-1pcgA:
98.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
LEU A 525
 EST  A   1 ( 4.0A)
None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 (-3.6A)
 0.68A 2jfaA-1pcgA:
34.1		 2jfaA-1pcgA:
98.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 TRP A 286
LEU A 290
ARG A 297
ILE A 344
LEU A 435
 None
EPH  A4000 ( 4.8A)
None
EPH  A4000 ( 4.1A)
EPH  A4000 ( 4.6A)
 0.80A 2jfaA-1r20A:
21.6		 2jfaA-1r20A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		6 ALA A 231
GLU A 230
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.11A 2jfaA-1sgvA:
undetectable		 2jfaA-1sgvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		6 ALA A 231
GLU A 230
LEU A 234
LEU A 226
LEU A 224
LEU A  63
 None
 1.15A 2jfaA-1sgvA:
undetectable		 2jfaA-1sgvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 343
LEU A 347
TRP A 376
LEU A 380
ARG A 387
ILE A 416
 MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
None
 0.99A 2jfaA-1uhlA:
22.8		 2jfaA-1uhlA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 343
LEU A 347
TRP A 376
LEU A 380
ARG A 387
ILE A 499
 MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
None
 1.12A 2jfaA-1uhlA:
22.8		 2jfaA-1uhlA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 343
TRP A 376
LEU A 380
ARG A 387
ILE A 416
LEU A 507
 MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
None
MEI  A1001 (-4.6A)
 0.93A 2jfaA-1uhlA:
22.8		 2jfaA-1uhlA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		6 ALA A 246
LEU A 250
TRP A 279
LEU A 283
ARG A 290
ILE A 402
 9CR  A 201 (-3.6A)
None
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-2.8A)
None
 1.04A 2jfaA-1xiuA:
23.3		 2jfaA-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 ALA A 246
LEU A 250
TRP A 279
LEU A 283
ILE A 319
 9CR  A 201 (-3.6A)
None
None
9CR  A 201 ( 4.1A)
None
 1.02A 2jfaA-1xiuA:
23.3		 2jfaA-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 ALA A 246
TRP A 279
LEU A 283
ARG A 290
LEU A 410
 9CR  A 201 (-3.6A)
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-2.8A)
9CR  A 201 ( 4.8A)
 0.83A 2jfaA-1xiuA:
23.3		 2jfaA-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 ALA A 246
TRP A 279
LEU A 283
ILE A 319
LEU A 410
 9CR  A 201 (-3.6A)
None
9CR  A 201 ( 4.1A)
None
9CR  A 201 ( 4.8A)
 0.89A 2jfaA-1xiuA:
23.3		 2jfaA-1xiuA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
LEU A 276
TRP A 305
ARG A 316
ILE A 345
 9CR  A 801 (-3.5A)
None
None
9CR  A 801 (-2.6A)
9CR  A 801 ( 4.5A)
 0.99A 2jfaA-1xlsA:
22.6		 2jfaA-1xlsA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
TRP A 305
ARG A 316
ILE A 345
LEU A 436
 9CR  A 801 (-3.5A)
None
9CR  A 801 (-2.6A)
9CR  A 801 ( 4.5A)
9CR  A 801 (-4.7A)
 0.91A 2jfaA-1xlsA:
22.6		 2jfaA-1xlsA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A 801 (-3.5A)
None
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.7A)
 0.86A 2jfaA-1xlsA:
22.6		 2jfaA-1xlsA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT

(Pyrococcus
abyssi) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		5 THR A  18
ALA A  17
LEU A  80
LEU A  82
ILE A  54
 None
 0.98A 2jfaA-1yz6A:
undetectable		 2jfaA-1yz6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zel HYPOTHETICAL PROTEIN
RV2827C

(Mycobacterium
tuberculosis) 		PF09407
(AbiEi_1)
PF13338
(AbiEi_4) 		5 THR A 189
ALA A 188
LEU A 234
LEU A 207
LEU A 220
 FMT  A 707 ( 4.6A)
None
None
None
None
 1.11A 2jfaA-1zelA:
undetectable		 2jfaA-1zelA:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 272
GLU A 275
LEU A 276
TRP A 305
LEU A 309
ARG A 316
 OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 (-4.9A)
None
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
 0.61A 2jfaA-2gpvA:
27.0		 2jfaA-2gpvA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
ARG A 394
ILE A 424
LEU A 525
 EST  A 596 (-4.8A)
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-3.6A)
 0.80A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
ARG A 394
MET A 421
LEU A 525
 EST  A 596 (-4.8A)
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 (-3.6A)
 0.80A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
ILE A 424
 EST  A 596 (-4.8A)
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
 0.58A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
 EST  A 596 (-4.8A)
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.51A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 343
THR A 347
GLU A 353
LEU A 354
TRP A 383
LEU A 387
LEU A 391
ARG A 394
MET A 421
 EST  A 596 (-4.8A)
None
EST  A 596 (-2.7A)
None
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.68A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		5 THR A1074
ALA A1077
GLU A1080
LEU A1081
LEU A1009
 None
 0.88A 2jfaA-2oxfA:
undetectable		 2jfaA-2oxfA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ALA A  36
TRP A  69
LEU A  77
ARG A  80
MET A 108
 1CA  A 247 (-3.6A)
None
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.64A 2jfaA-2q3yA:
25.1		 2jfaA-2q3yA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 THR A 193
ALA A 196
LEU A 200
LEU A 210
LEU A 102
 None
 0.90A 2jfaA-2vqrA:
undetectable		 2jfaA-2vqrA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 THR A 193
ALA A 196
LEU A 200
LEU A 210
LEU A 301
 None
 1.08A 2jfaA-2vqrA:
undetectable		 2jfaA-2vqrA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 THR A 193
ALA A 196
LEU A 200
LEU A 210
LEU A 102
 None
 0.84A 2jfaA-2w8sA:
undetectable		 2jfaA-2w8sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wch GENERAL
ODORANT-BINDING
PROTEIN 1

(Bombyx mori) 		PF01395
(PBP_GOBP) 		5 MET A   5
LEU A  16
LEU A  61
MET A  90
ILE A  94
 None
None
B7M  A1145 ( 4.7A)
None
B7M  A1145 ( 4.5A)
 1.01A 2jfaA-2wchA:
undetectable		 2jfaA-2wchA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wch GENERAL
ODORANT-BINDING
PROTEIN 1

(Bombyx mori) 		PF01395
(PBP_GOBP) 		5 MET A   5
THR A   9
LEU A  16
LEU A  61
MET A  90
 None
B7M  A1145 ( 4.1A)
None
B7M  A1145 ( 4.7A)
None
 1.01A 2jfaA-2wchA:
undetectable		 2jfaA-2wchA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5v MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88

(Homo sapiens) 		PF01582
(TIR) 		5 THR A  90
ALA A  93
LEU A 105
ILE A 108
LEU A 121
 None
 1.05A 2jfaA-2z5vA:
undetectable		 2jfaA-2z5vA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet RAS-RELATED PROTEIN
RAB-27B

(Mus musculus) 		PF00071
(Ras) 		5 ALA A  14
LEU A  15
LEU A  13
ILE A  10
LEU A 177
 None
 1.11A 2jfaA-2zetA:
undetectable		 2jfaA-2zetA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		5 ALA A  14
LEU A  15
LEU A  13
ILE A  10
LEU A 177
 None
 1.11A 2jfaA-3bc1A:
undetectable		 2jfaA-3bc1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 ALA A 347
GLU A 346
LEU A 350
LEU A 342
ARG A 339
ILE A 415
 None
 1.29A 2jfaA-3cgdA:
undetectable		 2jfaA-3cgdA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 THR A 319
GLU A 484
LEU A 487
LEU A 314
ILE A 213
 None
 1.05A 2jfaA-3dmyA:
undetectable		 2jfaA-3dmyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 ALA A 272
LEU A 276
TRP A 305
ILE A 345
LEU A 436
 9CR  A7223 (-4.2A)
None
None
9CR  A7223 ( 4.9A)
9CR  A7223 ( 4.7A)
 0.85A 2jfaA-3dzuA:
22.7		 2jfaA-3dzuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
ILE A 428
 9CR  A7223 (-4.2A)
None
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
None
 1.02A 2jfaA-3dzuA:
22.7		 2jfaA-3dzuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A7223 (-4.2A)
None
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
9CR  A7223 ( 4.7A)
 0.87A 2jfaA-3dzuA:
22.7		 2jfaA-3dzuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD

(Arthrobacter
sp. FB24) 		PF13794
(MiaE_2) 		5 ALA A  23
GLU A  26
LEU A  27
LEU A  62
MET A  70
 None
UNL  A 500 (-3.5A)
None
None
None
 1.10A 2jfaA-3ez0A:
undetectable		 2jfaA-3ez0A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7c PROTEIN OF UNKNOWN
FUNCTION (DUF416)

(Marinobacter
hydrocarbonoclasticus) 		PF04222
(DUF416) 		5 ALA A  26
GLU A  27
LEU A  23
LEU A  52
LEU A  75
 None
 1.13A 2jfaA-3f7cA:
undetectable		 2jfaA-3f7cA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF00392
(GntR)
PF07729
(FCD) 		5 THR A  72
GLU A  30
LEU A  32
LEU A  26
LEU A 159
 None
 1.08A 2jfaA-3fmsA:
undetectable		 2jfaA-3fmsA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyu NUCLEAR HORMONE
RECEPTOR OF THE
STEROID/THYROID
HORMONE RECEPTORS
SUPERFAMILY

(Strongyloides
stercoralis) 		PF00104
(Hormone_recep) 		5 MET A 569
LEU A 522
LEU A 657
ILE A 598
LEU A 664
 None
 1.11A 2jfaA-3gyuA:
19.5		 2jfaA-3gyuA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0y PUTATIVE POLYKETIDE
CYCLASE

(Xanthomonas
campestris) 		PF12680
(SnoaL_2) 		5 THR A 122
ALA A  33
GLU A  34
LEU A  29
LEU A  12
 None
 1.10A 2jfaA-3i0yA:
undetectable		 2jfaA-3i0yA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 MET A 533
THR A 537
ALA A 540
ILE A 397
LEU A 393
 None
 1.05A 2jfaA-3lppA:
undetectable		 2jfaA-3lppA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a DIHEME CYTOCHROME C
NAPB
PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF03892
(NapB)
PF04879
(Molybdop_Fe4S4) 		5 THR B  10
LEU A 491
ARG A  76
MET A 465
LEU A 774
 None
FMT  B 139 (-4.5A)
None
None
CL  A 816 (-4.0A)
 1.13A 2jfaA-3o5aB:
undetectable		 2jfaA-3o5aB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 MET A 499
ALA A 334
LEU A 335
LEU A 488
ILE A 305
 None
 1.02A 2jfaA-3qfkA:
undetectable		 2jfaA-3qfkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp6 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		5 THR A 175
ALA A 143
LEU A 104
ILE A 185
LEU A  58
 None
 1.04A 2jfaA-3qp6A:
undetectable		 2jfaA-3qp6A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp8 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF03472
(Autoind_bind) 		5 THR A 175
ALA A 143
LEU A 104
ILE A 185
LEU A  58
 None
 1.08A 2jfaA-3qp8A:
undetectable		 2jfaA-3qp8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 THR A 199
ALA A 198
LEU A 390
LEU A 175
ILE A  37
 None
 1.12A 2jfaA-3r75A:
undetectable		 2jfaA-3r75A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		6 ALA A 297
GLU A 300
LEU A 298
LEU A 107
ARG A 132
ILE A 203
 None
 1.42A 2jfaA-3wwxA:
undetectable		 2jfaA-3wwxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 THR B 306
ALA B 309
LEU A  67
LEU A  74
MET B 430
 None
None
None
None
S35  A1259 ( 4.6A)
 1.08A 2jfaA-4az3B:
undetectable		 2jfaA-4az3B:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		5 THR A  74
ALA A  73
LEU A   7
LEU A  69
MET A  52
 None
 1.10A 2jfaA-4dimA:
undetectable		 2jfaA-4dimA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 ALA A 406
GLU A 374
LEU A 415
ILE A 452
LEU A 434
 None
 1.07A 2jfaA-4fqdA:
undetectable		 2jfaA-4fqdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8n CONJUGATED
POLYKETONE REDUCTASE
C2

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		5 THR A 242
ALA A 236
GLU A 237
LEU A 235
LEU A 220
 None
None
None
None
NDP  A3001 ( 4.2A)
 1.11A 2jfaA-4h8nA:
undetectable		 2jfaA-4h8nA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		5 THR A 295
ALA A 298
GLU A 301
LEU A 302
LEU A 334
 None
 0.83A 2jfaA-4ix3A:
undetectable		 2jfaA-4ix3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 6 ALA D 272
LEU D 276
TRP D 305
LEU D 309
ARG D 316
ILE D 345
 None
 0.96A 2jfaA-4j5xD:
21.6		 2jfaA-4j5xD:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 6 ALA D 272
LEU D 276
TRP D 305
LEU D 309
ARG D 316
ILE D 428
 None
 1.08A 2jfaA-4j5xD:
21.6		 2jfaA-4j5xD:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 6 ALA D 272
TRP D 305
LEU D 309
ARG D 316
ILE D 345
LEU D 436
 None
 0.90A 2jfaA-4j5xD:
21.6		 2jfaA-4j5xD:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 THR A 306
ALA A 309
LEU A  67
LEU A  74
MET A 430
 THR  A 306 ( 0.8A)
ALA  A 309 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  74 ( 0.6A)
MET  A 430 ( 0.0A)
 1.11A 2jfaA-4mwtA:
undetectable		 2jfaA-4mwtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		6 THR A  41
ALA A  40
TRP A 255
LEU A 210
LEU A 213
ILE A  27
 None
 1.20A 2jfaA-4mwzA:
undetectable		 2jfaA-4mwzA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 ALA A 287
GLU A 290
LEU A 291
TRP A 320
LEU A 324
ARG A 331
 None
 0.42A 2jfaA-4n1yA:
27.5		 2jfaA-4n1yA:
35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 ALA A 287
GLU A 290
LEU A 324
ARG A 331
MET A 358
 None
 0.80A 2jfaA-4n1yA:
27.5		 2jfaA-4n1yA:
35.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		5 THR A  71
ALA A  74
GLU A  77
LEU A  78
LEU A   6
 None
 0.86A 2jfaA-4r2wA:
undetectable		 2jfaA-4r2wA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		6 ALA A 131
LEU A 134
LEU A  48
LEU A 124
ILE A  64
LEU A  45
 None
 1.44A 2jfaA-4rgyA:
undetectable		 2jfaA-4rgyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 773
TRP A 806
LEU A 810
LEU A 814
ARG A 817
 CV7  A1987 (-3.5A)
None
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
 0.52A 2jfaA-4udbA:
24.8		 2jfaA-4udbA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		5 THR A 123
ALA A 126
GLU A 129
ILE A  82
LEU A  16
 None
 1.03A 2jfaA-4wh0A:
undetectable		 2jfaA-4wh0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 563
TRP A 348
LEU A 421
LEU A 422
MET A 368
 None
 1.11A 2jfaA-4wziA:
3.2		 2jfaA-4wziA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN

(Homo sapiens) 		PF00975
(Thioesterase) 		5 ALA A 111
GLU A 121
LEU A 112
LEU A 200
LEU A 127
 None
 1.12A 2jfaA-4xjvA:
undetectable		 2jfaA-4xjvA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		5 ALA A 485
LEU A 482
LEU A 524
LEU A 521
ILE A 516
 None
 1.11A 2jfaA-5a29A:
undetectable		 2jfaA-5a29A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 THR A 206
ALA A 209
GLU A 212
LEU A 213
ILE A 186
 None
 0.71A 2jfaA-5allA:
undetectable		 2jfaA-5allA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 THR A 206
ALA A 209
GLU A 212
LEU A 213
LEU A 202
 None
 0.82A 2jfaA-5allA:
undetectable		 2jfaA-5allA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Mus musculus) 		PF12777
(MT) 		5 ALA A3394
LEU A3398
LEU A3325
LEU A3326
ILE A3336
 None
 0.99A 2jfaA-5ayhA:
undetectable		 2jfaA-5ayhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkm AT5G51070/K3K7_27

(Arabidopsis
thaliana) 		PF02861
(Clp_N) 		5 THR A 223
ALA A 197
LEU A 115
ARG A  86
LEU A 212
 None
 1.06A 2jfaA-5gkmA:
undetectable		 2jfaA-5gkmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 THR A 353
ALA A 283
LEU A 282
LEU A  38
ILE A 380
 None
 1.05A 2jfaA-5gmxA:
undetectable		 2jfaA-5gmxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 THR A 211
ALA A 214
GLU A 217
ARG A  95
LEU A 195
 None
 0.90A 2jfaA-5iq0A:
undetectable		 2jfaA-5iq0A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 ALA A 285
GLU A 286
LEU A 287
ARG A 318
ILE A 165
 None
 1.07A 2jfaA-5jd5A:
undetectable		 2jfaA-5jd5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqw 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		5 THR A  92
ALA A  94
GLU A  97
LEU A  98
LEU A 337
 None
 1.04A 2jfaA-5kqwA:
undetectable		 2jfaA-5kqwA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 THR A  73
ALA A  76
GLU A  79
LEU A  80
LEU A   8
 None
 0.81A 2jfaA-5lhvA:
undetectable		 2jfaA-5lhvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 5 LEU A 559
TRP A 490
LEU A 482
ILE A 543
LEU A 507
 None
 1.12A 2jfaA-5oatA:
undetectable		 2jfaA-5oatA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 ALA A 563
TRP A 348
LEU A 421
LEU A 422
MET A 368
 None
 1.10A 2jfaA-5ohjA:
2.1		 2jfaA-5ohjA:
15.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 294
GLU A 305
LEU A 343
ARG A 346
ILE A 376
 None
EST  A 601 (-2.4A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
 1.12A 2jfaA-5toaA:
30.1		 2jfaA-5toaA:
53.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 295
THR A 299
ALA A 302
GLU A 305
TRP A 335
LEU A 339
LEU A 343
ARG A 346
ILE A 376
LEU A 476
 EST  A 601 ( 4.4A)
None
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-3.5A)
 0.75A 2jfaA-5toaA:
30.1		 2jfaA-5toaA:
53.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 295
THR A 299
GLU A 305
LEU A 306
TRP A 335
LEU A 339
LEU A 343
ARG A 346
ILE A 376
LEU A 476
 EST  A 601 ( 4.4A)
None
EST  A 601 (-2.4A)
None
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-3.5A)
 0.85A 2jfaA-5toaA:
30.1		 2jfaA-5toaA:
53.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 6 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
ILE A 428
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
 1.20A 2jfaA-5uanA:
22.4		 2jfaA-5uanA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 5 ALA A 272
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
9CR  A 503 ( 4.8A)
 1.03A 2jfaA-5uanA:
22.4		 2jfaA-5uanA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 5 ALA A 117
LEU A 102
LEU A  94
LEU A  95
LEU A  70
 None
 1.03A 2jfaA-5wbfA:
undetectable		 2jfaA-5wbfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkt UREASE ACCESSORY
PROTEIN UREG

(Klebsiella
pneumoniae) 		no annotation 5 GLU A 104
LEU A  24
LEU A  23
ILE A 194
LEU A 100
 NI  A 302 ( 2.5A)
None
None
None
None
 1.09A 2jfaA-5xktA:
undetectable		 2jfaA-5xktA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 5 ALA A 174
LEU A 171
LEU A 105
LEU A 104
LEU A 112
 None
 1.07A 2jfaA-5xxgA:
undetectable		 2jfaA-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 GLU A  49
LEU A  48
LEU A 301
ARG A 335
ILE A 290
 CL  A 402 ( 4.6A)
None
CL  A 402 (-4.8A)
CL  A 402 (-3.5A)
None
 1.11A 2jfaA-6dllA:
undetectable		 2jfaA-6dllA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		4 LEU A 278
ASP A 275
MET A 310
LEU A 314
 None
 1.28A 2jfaA-1a4sA:
2.3		 2jfaA-1a4sA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT
[NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU B 121
ASP B 125
LEU B 206
HIS A  45
 None
 1.23A 2jfaA-1e3dB:
1.1		 2jfaA-1e3dB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		4 ASP A 393
MET A 405
LEU A 420
HIS A 513
 None
 1.29A 2jfaA-1gqrA:
undetectable		 2jfaA-1gqrA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ASP A 409
MET A 264
LEU A 225
HIS A  90
 None
None
None
ZN  A1102 ( 3.3A)
 0.98A 2jfaA-1hwwA:
undetectable		 2jfaA-1hwwA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT
II

(Salmonella
enterica) 		PF00117
(GATase) 		4 LEU B 143
ASP B 159
LEU B  70
HIS B  86
 None
 1.24A 2jfaA-1i1qB:
0.0		 2jfaA-1i1qB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens) 		PF00117
(GATase) 		4 LEU B 146
ASP B 162
LEU B  72
HIS B  88
 None
 1.10A 2jfaA-1i7qB:
0.0		 2jfaA-1i7qB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		4 LEU A 197
MET A   9
LEU A  60
HIS A 210
 None
None
None
FE2  A 500 ( 3.5A)
 1.06A 2jfaA-1lkdA:
undetectable		 2jfaA-1lkdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.20A 2jfaA-1lpfA:
undetectable		 2jfaA-1lpfA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrv LEUCINE-RICH REPEAT
VARIANT

(Azotobacter
vinelandii) 		PF01816
(LRV)
PF05484
(LRV_FeS) 		4 LEU A 212
ASP A 207
LEU A 223
HIS A 217
 None
 1.18A 2jfaA-1lrvA:
undetectable		 2jfaA-1lrvA:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
MET A 388
LEU A 428
HIS A 524
 EST  A   1 (-4.4A)
None
None
EST  A   1 (-3.8A)
 0.46A 2jfaA-1pcgA:
34.1		 2jfaA-1pcgA:
98.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		4 LEU A 451
ASP A 443
LEU A 589
HIS A 458
 None
 1.28A 2jfaA-1qjmA:
undetectable		 2jfaA-1qjmA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8i TRAC

(Escherichia
coli) 		PF07996
(T4SS) 		4 LEU A  41
ASP A 172
MET A 160
LEU A  48
 None
 1.17A 2jfaA-1r8iA:
undetectable		 2jfaA-1r8iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		4 LEU A  47
ASP A 101
LEU A   9
HIS A 120
 None
None
None
CU  A 155 (-3.0A)
 1.05A 2jfaA-1srdA:
undetectable		 2jfaA-1srdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv0 ETS DNA-BINDING
PROTEIN POKKURI

(Drosophila
melanogaster) 		PF02198
(SAM_PNT) 		4 LEU A 113
ASP A  50
LEU A  63
HIS A 107
 None
 1.30A 2jfaA-1sv0A:
undetectable		 2jfaA-1sv0A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 LEU B 113
ASP B 117
MET B  45
HIS B  60
 None
 0.75A 2jfaA-1sxjB:
undetectable		 2jfaA-1sxjB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		4 LEU A 126
ASP A 121
MET A  52
LEU A  56
 None
 1.24A 2jfaA-1xqpA:
undetectable		 2jfaA-1xqpA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		4 LEU B 265
ASP B 238
LEU B 321
HIS B 324
 None
 1.24A 2jfaA-1zunB:
undetectable		 2jfaA-1zunB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		4 LEU A 310
ASP A 314
MET A 323
LEU A 302
 None
 1.29A 2jfaA-2a8iA:
undetectable		 2jfaA-2a8iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4a BH3024

(Bacillus
halodurans) 		PF00072
(Response_reg) 		4 LEU A 100
ASP A  56
LEU A  23
HIS A 116
 None
 1.02A 2jfaA-2b4aA:
undetectable		 2jfaA-2b4aA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crf RAN BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		4 LEU A  67
ASP A  64
LEU A  56
HIS A 134
 None
 0.97A 2jfaA-2crfA:
undetectable		 2jfaA-2crfA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		4 LEU A  70
ASP A 165
LEU A 102
HIS A  49
 None
 1.14A 2jfaA-2cybA:
undetectable		 2jfaA-2cybA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc5 GLUTATHIONE
S-TRANSFERASE, MU 7

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 107
ASP A 113
MET A 142
LEU A 188
 None
 1.30A 2jfaA-2dc5A:
undetectable		 2jfaA-2dc5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 439
ASP A 407
MET A 432
LEU A 428
 None
 1.26A 2jfaA-2eq9A:
undetectable		 2jfaA-2eq9A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		4 LEU A  63
ASP A 100
MET A  50
LEU A  75
 None
 1.23A 2jfaA-2iuyA:
undetectable		 2jfaA-2iuyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		4 LEU A 517
MET A 457
LEU A 568
HIS A 554
 None
 1.24A 2jfaA-2jh9A:
undetectable		 2jfaA-2jh9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb2 BLRP1

(Klebsiella
pneumoniae) 		PF04940
(BLUF) 		4 LEU A  43
ASP A  99
LEU A  80
HIS A  74
 FMN  A 149 ( 4.3A)
None
None
FMN  A 149 ( 3.6A)
 1.16A 2jfaA-2kb2A:
undetectable		 2jfaA-2kb2A:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
MET A 388
LEU A 428
HIS A 524
 EST  A 596 (-4.4A)
None
None
EST  A 596 (-4.2A)
 0.44A 2jfaA-2ocfA:
32.7		 2jfaA-2ocfA:
91.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		4 LEU A  40
ASP A 178
MET A  70
LEU A  79
 None
 1.26A 2jfaA-2ozeA:
undetectable		 2jfaA-2ozeA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00215
(OMPdecase) 		4 LEU A  91
ASP A 149
LEU A  78
HIS A 116
 None
None
None
CSX  A 115 ( 3.9A)
 1.31A 2jfaA-2p1fA:
undetectable		 2jfaA-2p1fA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbx HEMAGGLUTININ/PROTEA
SE REGULATORY
PROTEIN

(Vibrio cholerae) 		PF00440
(TetR_N) 		4 LEU A  80
MET A 101
LEU A 112
HIS A 168
 None
 1.26A 2jfaA-2pbxA:
undetectable		 2jfaA-2pbxA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A 178
ASP A 174
MET A 239
LEU A 186
 None
 1.19A 2jfaA-2pwhA:
undetectable		 2jfaA-2pwhA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind)
PF09228
(Prok-TraM) 		4 LEU A 161
ASP C  72
MET A 128
LEU A 154
 None
 1.10A 2jfaA-2q0oA:
undetectable		 2jfaA-2q0oA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		4 LEU A  35
ASP A 285
LEU A 123
HIS A 116
 None
 1.28A 2jfaA-2q14A:
undetectable		 2jfaA-2q14A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 LEU A  51
ASP A  82
LEU A 104
HIS A 114
 None
 1.30A 2jfaA-2qedA:
undetectable		 2jfaA-2qedA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU A 233
ASP A 226
LEU A 258
HIS A 201
 None
 1.17A 2jfaA-2rfaA:
undetectable		 2jfaA-2rfaA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 490
ASP A 688
MET A 193
LEU A 189
 None
 1.21A 2jfaA-2xf2A:
undetectable		 2jfaA-2xf2A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 LEU A 907
ASP A1000
MET A1020
LEU A 841
 None
 1.31A 2jfaA-2xhsA:
18.1		 2jfaA-2xhsA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 LEU A  48
ASP A  31
LEU A  67
HIS A  22
 None
None
HEM  A 350 ( 4.8A)
None
 0.84A 2jfaA-2yp1A:
undetectable		 2jfaA-2yp1A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 179
ASP A 169
LEU A 227
HIS A 206
 None
 1.27A 2jfaA-2z81A:
undetectable		 2jfaA-2z81A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 LEU A 157
ASP A 182
MET A  93
HIS A  64
 HTL  A 827 (-3.9A)
MG  A 826 ( 2.8A)
None
HTL  A 827 (-4.3A)
 1.16A 2jfaA-3ahiA:
undetectable		 2jfaA-3ahiA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 LEU A 157
ASP A 182
MET A  93
HIS A  64
 TPP  A 900 (-4.0A)
CA  A 901 ( 3.0A)
None
None
 1.16A 2jfaA-3ai7A:
undetectable		 2jfaA-3ai7A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak4 NADH-DEPENDENT
QUINUCLIDINONE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 LEU A  87
ASP A  85
MET A 174
LEU A 170
 None
 1.26A 2jfaA-3ak4A:
undetectable		 2jfaA-3ak4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq8 SENSOR PROTEIN PHOQ

(Escherichia
coli) 		PF08918
(PhoQ_Sensor) 		4 LEU A 132
ASP A 125
MET A 106
LEU A  87
 None
 1.24A 2jfaA-3bq8A:
undetectable		 2jfaA-3bq8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		4 ASP A 152
MET A 213
LEU A 230
HIS A 223
 None
 1.12A 2jfaA-3cijA:
undetectable		 2jfaA-3cijA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED

(Myxococcus
xanthus) 		PF00204
(DNA_gyraseB) 		4 LEU A 299
ASP A 247
LEU A 279
HIS A 346
 None
 1.12A 2jfaA-3cwvA:
undetectable		 2jfaA-3cwvA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		4 LEU A 241
ASP A 351
MET A 302
LEU A 273
 None
 1.24A 2jfaA-3d3lA:
undetectable		 2jfaA-3d3lA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		4 LEU A 205
ASP A 226
LEU A 198
HIS A 263
 None
 1.07A 2jfaA-3gzsA:
undetectable		 2jfaA-3gzsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 LEU A   9
ASP A  14
MET A  46
HIS A  61
 None
 1.25A 2jfaA-3kd8A:
undetectable		 2jfaA-3kd8A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kin KINESIN HEAVY CHAIN

(Rattus
norvegicus) 		PF00225
(Kinesin) 		4 LEU A 210
ASP A 145
MET B 284
LEU B 288
 None
 1.07A 2jfaA-3kinA:
undetectable		 2jfaA-3kinA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmz PUTATIVE SUGAR
ISOMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 LEU A  58
ASP A  77
MET A  48
LEU A  65
 None
 1.20A 2jfaA-3lmzA:
undetectable		 2jfaA-3lmzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU B1111
ASP B1115
LEU B1195
HIS A  44
 None
 1.16A 2jfaA-3myrB:
1.3		 2jfaA-3myrB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 LEU A  21
ASP A 470
LEU A 461
HIS A  78
 None
 1.01A 2jfaA-3nvlA:
undetectable		 2jfaA-3nvlA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odh OKRAI ENDONUCLEASE

(Oceanobacter
kriegii) 		PF02923
(BamHI) 		4 LEU A 131
ASP A  86
LEU A   9
HIS A 109
 None
CA  A 195 ( 2.4A)
None
None
 1.30A 2jfaA-3odhA:
undetectable		 2jfaA-3odhA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		4 ASP A  23
MET A 261
LEU A 228
HIS A 298
 None
 1.16A 2jfaA-3pmkA:
undetectable		 2jfaA-3pmkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		4 LEU A 125
ASP A 131
LEU A  20
HIS A  97
 None
 1.10A 2jfaA-3rysA:
undetectable		 2jfaA-3rysA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rzv STAM-BINDING PROTEIN

(Homo sapiens) 		PF01398
(JAB) 		4 LEU A 263
ASP A 415
LEU A 331
HIS A 298
 None
 1.29A 2jfaA-3rzvA:
undetectable		 2jfaA-3rzvA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 LEU B 603
ASP B 625
LEU B 524
HIS B 598
 None
 1.26A 2jfaA-3tixB:
undetectable		 2jfaA-3tixB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzw POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 LEU A1015
ASP A1020
MET A1029
LEU A 787
 None
None
EDO  A   8 (-4.3A)
None
 1.30A 2jfaA-3tzwA:
undetectable		 2jfaA-3tzwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 LEU A 867
ASP A 862
LEU A 840
HIS A 872
 None
 1.18A 2jfaA-3ux8A:
undetectable		 2jfaA-3ux8A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		4 LEU A  13
ASP A  10
MET A 285
LEU A 283
 None
 1.14A 2jfaA-3vcyA:
undetectable		 2jfaA-3vcyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 LEU A  49
ASP A  67
LEU A 183
HIS A  52
 None
 1.25A 2jfaA-3wibA:
undetectable		 2jfaA-3wibA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU E 421
ASP E 426
LEU E 475
HIS E 416
 None
 1.19A 2jfaA-4a0lE:
undetectable		 2jfaA-4a0lE:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		4 LEU A 139
MET A 131
LEU A  96
HIS A  32
 None
 1.06A 2jfaA-4cs6A:
undetectable		 2jfaA-4cs6A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		4 LEU A 181
ASP A 188
MET A 224
LEU A  31
 None
 1.27A 2jfaA-4f48A:
undetectable		 2jfaA-4f48A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 LEU  A 232 ( 0.5A)
ASP  A 235 ( 0.5A)
LEU  A 138 ( 0.5A)
HIS  A 257 ( 1.0A)
 1.22A 2jfaA-4flxA:
undetectable		 2jfaA-4flxA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxb PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 LEU A 265
ASP A 267
MET A 257
LEU A 370
 None
 1.06A 2jfaA-4fxbA:
undetectable		 2jfaA-4fxbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 281
ASP A 415
MET A 311
LEU A 274
 None
 1.16A 2jfaA-4g1pA:
undetectable		 2jfaA-4g1pA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9b BETA-PHOSPHOGLUCOMUT
ASE

(Escherichia
coli) 		PF13419
(HAD_2) 		4 LEU A  10
ASP A 172
LEU A  89
HIS A  21
 CL  A 303 (-4.0A)
MG  A 301 (-2.6A)
None
SO4  A 307 (-4.0A)
 1.14A 2jfaA-4g9bA:
undetectable		 2jfaA-4g9bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI

(Caulobacter
vibrioides) 		PF06230
(DUF1009) 		4 LEU A 191
ASP A 196
LEU A 269
HIS A 235
 None
 0.74A 2jfaA-4j6eA:
undetectable		 2jfaA-4j6eA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 367
ASP A 362
LEU A 328
HIS A 433
 None
 1.30A 2jfaA-4k2bA:
undetectable		 2jfaA-4k2bA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		4 LEU A 207
ASP A 210
MET A 266
LEU A 270
 None
 1.20A 2jfaA-4lx4A:
undetectable		 2jfaA-4lx4A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 LEU A 798
ASP A 791
LEU A 782
HIS A 889
 None
 1.24A 2jfaA-4n78A:
undetectable		 2jfaA-4n78A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN

(Pseudomonas sp.
ECU1011) 		PF07859
(Abhydrolase_3) 		4 ASP A 256
MET A 304
LEU A 104
HIS A  97
 None
 1.29A 2jfaA-4ou4A:
undetectable		 2jfaA-4ou4A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0e MAF-LIKE PROTEIN
YHDE

(Escherichia
coli) 		PF02545
(Maf) 		4 LEU A  93
ASP A 131
LEU A 144
HIS A  88
 None
 0.78A 2jfaA-4p0eA:
undetectable		 2jfaA-4p0eA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 LEU A 208
MET A 244
LEU A 260
HIS A 215
 None
 1.21A 2jfaA-4p3zA:
3.0		 2jfaA-4p3zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE

(Lactobacillus
jensenii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 230
MET A 215
LEU A 238
HIS A 205
 None
 1.30A 2jfaA-4prkA:
undetectable		 2jfaA-4prkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 LEU A 741
ASP A 743
MET A 840
LEU A 756
 None
 1.26A 2jfaA-4q8hA:
undetectable		 2jfaA-4q8hA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		4 LEU A 155
ASP A  21
LEU A  70
HIS A  11
 None
 1.21A 2jfaA-4qr8A:
undetectable		 2jfaA-4qr8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF01547
(SBP_bac_1) 		4 LEU A 231
ASP A 176
LEU A 413
HIS A 399
 None
 1.15A 2jfaA-4rk2A:
undetectable		 2jfaA-4rk2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii) 		PF00080
(Sod_Cu) 		4 LEU A  59
ASP A 113
LEU A  21
HIS A 132
 None
 1.06A 2jfaA-4rvpA:
undetectable		 2jfaA-4rvpA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT
PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU L 131
ASP L 135
LEU L 216
HIS S  45
 None
 1.13A 2jfaA-4u9iL:
1.0		 2jfaA-4u9iL:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye9 GLUTAMINE--TRNA
LIGASE

(Homo sapiens) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2)
PF04558
(tRNA_synt_1c_R1) 		4 LEU A 402
ASP A 414
MET A 380
LEU A 384
 None
 1.30A 2jfaA-4ye9A:
undetectable		 2jfaA-4ye9A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG

(Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind) 		4 LEU A 136
ASP A 161
MET A 175
LEU A 107
 None
 1.17A 2jfaA-4yryA:
undetectable		 2jfaA-4yryA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG

(Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind) 		4 LEU A 136
ASP A 162
MET A 175
LEU A 107
 None
NAD  A 503 ( 3.7A)
None
None
 0.93A 2jfaA-4yryA:
undetectable		 2jfaA-4yryA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 217
ASP A 212
LEU A 226
HIS A 222
 None
 1.13A 2jfaA-4z0cA:
undetectable		 2jfaA-4z0cA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 LEU A 237
ASP A 240
LEU A 312
HIS A 208
 None
 1.16A 2jfaA-5ddsA:
undetectable		 2jfaA-5ddsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmk PRE-MRNA-SPLICING
FACTOR CWC22

(Saccharomyces
cerevisiae) 		PF02847
(MA3) 		4 LEU Z  94
MET Z  99
LEU Z 121
HIS Z 225
 None
 1.13A 2jfaA-5gmkZ:
undetectable		 2jfaA-5gmkZ:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 None
 1.26A 2jfaA-5h12A:
undetectable		 2jfaA-5h12A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 276
ASP A 282
MET A  58
LEU A 258
 None
 0.92A 2jfaA-5iy9A:
undetectable		 2jfaA-5iy9A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU B 302
ASP A  38
LEU B 291
HIS B 307
 None
 1.14A 2jfaA-5l3sB:
undetectable		 2jfaA-5l3sB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin)
no annotation 		4 LEU B 942
ASP A  77
MET B 907
LEU B 893
 None
 0.98A 2jfaA-5lxvB:
undetectable		 2jfaA-5lxvB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN5

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 LEU P 293
ASP P 287
LEU P 322
HIS P 263
 None
 1.25A 2jfaA-5mpdP:
undetectable		 2jfaA-5mpdP:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA

(Chaetomium
thermophilum) 		PF01602
(Adaptin_N) 		4 LEU A 338
ASP A 305
MET A 320
LEU A 356
 None
 1.28A 2jfaA-5mu7A:
undetectable		 2jfaA-5mu7A:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 298
MET A 340
LEU A 380
HIS A 475
 EST  A 601 (-4.1A)
EST  A 601 ( 4.8A)
None
EST  A 601 (-4.4A)
 0.46A 2jfaA-5toaA:
30.1		 2jfaA-5toaA:
53.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqk SULFURTRANSFERASE

(Mus musculus) 		PF00581
(Rhodanese) 		4 LEU A 128
ASP A 101
LEU A  20
HIS A  96
 None
 1.30A 2jfaA-5wqkA:
undetectable		 2jfaA-5wqkA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii) 		PF01501
(Glyco_transf_8) 		4 LEU A1277
ASP A1280
LEU A1384
HIS A1375
 None
 1.24A 2jfaA-5y7fA:
undetectable		 2jfaA-5y7fA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 LEU 2 322
ASP 2 324
MET 2 290
LEU 2 793
 None
 1.05A 2jfaA-5zvs2:
undetectable		 2jfaA-5zvs2:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 4 LEU A 134
ASP A 118
LEU A  73
HIS A 108
 None
 1.25A 2jfaA-6bk5A:
undetectable		 2jfaA-6bk5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 4 LEU A 125
ASP A 122
MET A 142
LEU A  48
 None
 0.98A 2jfaA-6ekvA:
undetectable		 2jfaA-6ekvA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B 131
ASP B 193
LEU B 165
HIS B 115
 None
 1.07A 2jfaA-6emkB:
undetectable		 2jfaA-6emkB:
15.87