SIMILAR PATTERNS OF AMINO ACIDS FOR 2JC9_A_ADNA1498

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Coccidioides
posadasii) 		PF00579
(tRNA-synt_1b) 		4 PHE A 192
ARG A 187
MET A 129
MET A 133
 None
 1.43A 2jc9A-5ijxA:
0.0		 2jc9A-5ijxA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		4 PHE A  97
HIS A  93
MET A  85
MET A  83
 None
 1.34A 2jc9A-5vj1A:
2.2		 2jc9A-5vj1A:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 5 PHE A 127
ARG A 129
HIS A 428
MET A 432
MET A 436
 None
PO4  A 603 ( 4.9A)
None
None
None
 0.44A 2jc9A-6dd3A:
61.2		 2jc9A-6dd3A:
79.80