SIMILAR PATTERNS OF AMINO ACIDS FOR 2JC9_A_ADNA1497_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq2 ADP-L-GLYCERO-D-MANN
OHEPTOSE 6-EPIMERASE

(Escherichia
coli) 		PF01370
(Epimerase) 		4 ASP A  31
THR A   5
ILE A  15
ASN A 221
 NAP  A2400 (-2.8A)
NAP  A2400 ( 4.4A)
None
None
 1.24A 2jc9A-1eq2A:
2.7		 2jc9A-1eq2A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hng CD2

(Rattus rattus) 		PF05790
(C2-set)
PF07686
(V-set) 		4 ARG A  34
ASP A  71
THR A  69
ILE A  65
 None
 1.23A 2jc9A-1hngA:
undetectable		 2jc9A-1hngA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 ARG A 302
THR A  39
ILE A 297
ASN A 448
 None
 1.08A 2jc9A-1iduA:
undetectable		 2jc9A-1iduA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		4 ARG A  59
THR A  15
ILE A  57
PHE A  54
 None
 1.25A 2jc9A-1j85A:
3.4		 2jc9A-1j85A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		4 ASP B  76
THR B  80
ILE B 145
ASN B 144
 None
 0.90A 2jc9A-1jk0B:
undetectable		 2jc9A-1jk0B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 ASP A 114
THR A 112
ILE A 103
PHE A 267
 None
 1.25A 2jc9A-1l1lA:
0.5		 2jc9A-1l1lA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np3 KETOL-ACID
REDUCTOISOMERASE

(Pseudomonas
aeruginosa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ARG A 280
ILE A 281
PHE A 192
GLN A 195
 None
 1.14A 2jc9A-1np3A:
undetectable		 2jc9A-1np3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		4 ARG A 588
THR A 581
ILE A 178
ASN A 171
 None
 1.25A 2jc9A-1pxyA:
undetectable		 2jc9A-1pxyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5e AVIRULENCE PROTEIN

(Pseudomonas
syringae) 		PF11592
(AvrPto) 		4 ARG A  88
ILE A  96
ASN A  97
GLN A  86
 None
 1.06A 2jc9A-1r5eA:
undetectable		 2jc9A-1r5eA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 THR A 220
ILE A 187
ASN A 138
PHE A 188
 None
 1.04A 2jc9A-1rm8A:
undetectable		 2jc9A-1rm8A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we8 TUDOR AND KH DOMAIN
CONTAINING PROTEIN

(Mus musculus) 		PF00013
(KH_1) 		4 ASP A  51
THR A  49
ILE A  66
PHE A  16
 None
 0.91A 2jc9A-1we8A:
undetectable		 2jc9A-1we8A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xly SHE2P

(Saccharomyces
cerevisiae) 		PF11435
(She2p) 		4 ASP A 227
ILE A 144
ASN A 114
PHE A 110
 None
 1.11A 2jc9A-1xlyA:
undetectable		 2jc9A-1xlyA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 ASP A 226
ILE A 322
ASN A 301
GLN A  84
 None
 1.13A 2jc9A-1xr6A:
undetectable		 2jc9A-1xr6A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF13649
(Methyltransf_25) 		4 ASP A 225
THR A 240
ILE A 143
ASN A 114
 None
 1.04A 2jc9A-1y8cA:
2.1		 2jc9A-1y8cA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5e PROTEIN
DISULFIDE-ISOMERASE

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 ASP A 336
ILE A 342
PHE A 311
GLN A 329
 None
 1.15A 2jc9A-2b5eA:
undetectable		 2jc9A-2b5eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		4 ARG A 446
ASP A 463
THR A 467
ASN A  76
 None
 1.23A 2jc9A-2c4mA:
2.5		 2jc9A-2c4mA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ASP A 283
THR A 315
ILE A 325
PHE A 327
 None
 1.24A 2jc9A-2ft3A:
undetectable		 2jc9A-2ft3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A

(Homo sapiens) 		no annotation 4 ARG N 501
ASP N 452
ILE I 425
GLN I 515
 None
 1.25A 2jc9A-2gk1N:
undetectable		 2jc9A-2gk1N:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		4 ASP A 338
ILE A 199
PHE A 192
GLN A 264
 None
 1.11A 2jc9A-2jf7A:
2.4		 2jc9A-2jf7A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxu TERB

(Klebsiella
pneumoniae) 		PF05099
(TerB) 		4 THR A  12
ILE A  75
ASN A  79
PHE A  78
 None
 1.17A 2jc9A-2jxuA:
undetectable		 2jc9A-2jxuA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okm COLLAGEN ADHESIN

(Enterococcus
faecalis) 		PF05737
(Collagen_bind) 		4 THR A  88
ILE A 136
ASN A  58
PHE A  56
 None
 1.05A 2jc9A-2okmA:
undetectable		 2jc9A-2okmA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens) 		PF12849
(PBP_like_2) 		4 ASP A 312
THR A  21
ILE A   2
PHE A 297
 None
 1.19A 2jc9A-2q9tA:
undetectable		 2jc9A-2q9tA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 156
ASP A 163
ILE A 166
PHE A 377
 None
 1.27A 2jc9A-2qygA:
undetectable		 2jc9A-2qygA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica) 		PF13416
(SBP_bac_8) 		4 ARG A 143
THR A 141
ASN A  92
GLN A 189
 ADA  A1431 ( 2.8A)
ADA  A1433 ( 4.5A)
None
ADA  A1432 ( 2.8A)
 1.11A 2jc9A-2uvjA:
undetectable		 2jc9A-2uvjA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica) 		PF13416
(SBP_bac_8) 		4 ARG A 143
THR A 272
ASN A  90
GLN A 189
 ADA  A1431 ( 2.8A)
ADA  A1433 (-3.4A)
ADA  A1433 (-3.0A)
ADA  A1432 ( 2.8A)
 1.01A 2jc9A-2uvjA:
undetectable		 2jc9A-2uvjA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		4 ASP A 268
THR A 169
ASN A 336
GLN A 137
 ZZU  A1359 (-3.0A)
None
None
ZZU  A1359 (-3.8A)
 1.23A 2jc9A-2wbpA:
undetectable		 2jc9A-2wbpA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wo3 EPHRIN-A2

(Homo sapiens) 		PF00812
(Ephrin) 		4 ARG B 143
THR B 173
ILE B  65
ASN B  66
 None
 1.08A 2jc9A-2wo3B:
undetectable		 2jc9A-2wo3B:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x11 EPHRIN-A5

(Homo sapiens) 		PF00812
(Ephrin) 		4 ARG B 135
THR B 166
ILE B  58
ASN B  59
 None
 1.11A 2jc9A-2x11B:
undetectable		 2jc9A-2x11B:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3m HYPOTHETICAL PROTEIN
ORF239

(Pyrobaculum
spherical virus) 		no annotation 4 ARG A 156
ASP A 157
ILE A 167
ASN A 213
 None
 1.21A 2jc9A-2x3mA:
undetectable		 2jc9A-2x3mA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x86 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Escherichia
coli) 		PF01370
(Epimerase) 		4 ASP A  31
THR A   5
ILE A  15
ASN A 221
 NAP  A 400 (-2.9A)
NAP  A 400 ( 4.5A)
None
None
 1.26A 2jc9A-2x86A:
2.7		 2jc9A-2x86A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1p COLLAGEN ADHESIN
PROTEIN

(Enterococcus
faecalis) 		PF05737
(Collagen_bind) 		4 THR A 227
ILE A 275
ASN A 197
PHE A 195
 None
 0.96A 2jc9A-2z1pA:
undetectable		 2jc9A-2z1pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ARG A 362
ILE A 360
ASN A 346
PHE A 278
 None
 1.23A 2jc9A-2zu6A:
undetectable		 2jc9A-2zu6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		4 ARG A 235
ASP A 234
ILE A 211
PHE A 201
 None
 1.06A 2jc9A-3b3jA:
2.9		 2jc9A-3b3jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 214
THR A 195
ILE A 239
ASN A 241
 None
None
NAP  A 372 ( 4.2A)
NAP  A 372 (-4.2A)
 1.26A 2jc9A-3b70A:
3.5		 2jc9A-3b70A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOB

(Methylosinus
trichosporium) 		PF02461
(AMO)
PF04744
(Monooxygenase_B) 		4 ARG A 119
ASP B 187
PHE A 116
GLN A 276
 None
 1.26A 2jc9A-3chxA:
undetectable		 2jc9A-3chxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF13377
(Peripla_BP_3) 		4 ARG A 196
ASP A 187
PHE A  75
GLN A 291
 GOL  A 500 (-2.5A)
None
GOL  A 500 (-4.5A)
GOL  A 500 (-4.5A)
 1.19A 2jc9A-3clkA:
undetectable		 2jc9A-3clkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT

(Mus musculus) 		PF00503
(G-alpha) 		4 ASP A 369
THR A 241
ILE A  51
PHE A 218
 None
 1.19A 2jc9A-3cx6A:
undetectable		 2jc9A-3cx6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		4 ASP A 294
THR A 292
ILE A   8
ASN A 252
 None
 1.26A 2jc9A-3e02A:
undetectable		 2jc9A-3e02A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		4 ASP A  71
THR A  73
ILE A 121
PHE A 145
 None
 1.26A 2jc9A-3ga7A:
undetectable		 2jc9A-3ga7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 ASP P 463
ASN P 421
PHE P 419
GLN P 437
 None
 1.01A 2jc9A-3hbuP:
undetectable		 2jc9A-3hbuP:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 268
ASP A 273
ILE A 278
PHE A 141
 None
 0.91A 2jc9A-3kdnA:
undetectable		 2jc9A-3kdnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxf SB27 T CELL RECEPTOR
ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 ASP D  17
THR D  77
ILE D  59
ASN D  57
 None
 1.15A 2jc9A-3kxfD:
undetectable		 2jc9A-3kxfD:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		4 ARG A  74
ILE A 108
PHE A  57
GLN A  49
 IUM  A 428 ( 4.2A)
None
None
None
 1.07A 2jc9A-3l0oA:
undetectable		 2jc9A-3l0oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ASP A 556
ILE A 563
ASN A 565
PHE A 536
 None
 0.82A 2jc9A-3la4A:
undetectable		 2jc9A-3la4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 ASP A 290
ILE A 393
ASN A 257
PHE A 247
 None
 1.25A 2jc9A-3lv4A:
undetectable		 2jc9A-3lv4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 ASP A 224
THR A 246
ILE A 268
GLN A 273
 None
 1.19A 2jc9A-3mzvA:
undetectable		 2jc9A-3mzvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nro LMO1026 PROTEIN

(Listeria
monocytogenes) 		PF03816
(LytR_cpsA_psr) 		4 ARG A 222
ASP A 219
ILE A 226
ASN A 230
 None
 1.10A 2jc9A-3nroA:
undetectable		 2jc9A-3nroA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 ARG A  72
ILE A  55
PHE A  54
GLN A  13
 None
 1.06A 2jc9A-3sdoA:
undetectable		 2jc9A-3sdoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		4 ASP A 426
THR A 347
ILE A 404
ASN A 416
 None
 1.27A 2jc9A-3sfwA:
undetectable		 2jc9A-3sfwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		4 ASP A 318
THR A  21
ILE A   2
PHE A 303
 None
 1.20A 2jc9A-3w9vA:
undetectable		 2jc9A-3w9vA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 ASP A 210
ILE A 228
ASN A 229
PHE A 134
 None
 1.27A 2jc9A-4aioA:
undetectable		 2jc9A-4aioA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		4 THR A  14
ILE A 419
ASN A 437
GLN A  57
 None
 1.18A 2jc9A-4b3kA:
undetectable		 2jc9A-4b3kA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ASP A 358
ILE A 430
PHE A 427
GLN A 431
 None
 1.12A 2jc9A-4c3hA:
2.1		 2jc9A-4c3hA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e72 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF11738
(DUF3298) 		4 ASP A 214
THR A 199
ASN A 144
PHE A 142
 None
 1.25A 2jc9A-4e72A:
undetectable		 2jc9A-4e72A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF14488
(DUF4434)
PF17134
(DUF5109) 		4 ASP A 157
THR A 196
ILE A 200
PHE A 203
 PE4  A 405 (-2.4A)
None
None
None
 1.16A 2jc9A-4h41A:
undetectable		 2jc9A-4h41A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hlz FAB C179 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG G  52
ASP G  52
THR G  30
PHE G  99
 None
 1.21A 2jc9A-4hlzG:
undetectable		 2jc9A-4hlzG:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgl HYPOTHETICAL PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 ASP A 141
THR A 139
ILE A 137
ASN A 100
 None
CA  A 202 (-3.6A)
None
None
 1.26A 2jc9A-4jglA:
undetectable		 2jc9A-4jglA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo sapiens) 		PF00328
(His_Phos_2) 		4 ASP A 194
ILE A 307
ASN A 311
PHE A 160
 None
 1.15A 2jc9A-4jocA:
undetectable		 2jc9A-4jocA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kms ACETOACETYL-COA
REDUCTASE

(Rickettsia
felis) 		PF13561
(adh_short_C2) 		4 THR A 166
ILE A 130
ASN A 132
PHE A 158
 None
 1.26A 2jc9A-4kmsA:
4.4		 2jc9A-4kmsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF02557
(VanY) 		4 ARG A 127
ASP A 167
THR A 165
GLN A 132
 None
ZN  A 400 ( 1.8A)
None
None
 1.16A 2jc9A-4mphA:
undetectable		 2jc9A-4mphA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npk EXTENDED
SYNAPTOTAGMIN-2

(Homo sapiens) 		PF00168
(C2) 		4 ASP A 628
THR A 630
ILE A 539
ASN A 587
 None
 1.10A 2jc9A-4npkA:
undetectable		 2jc9A-4npkA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Xanthobacter
autotrophicus) 		PF03480
(DctP) 		4 ARG A  88
THR A  93
ASN A 208
GLN A  34
 GTR  A 403 (-2.6A)
None
GTR  A 403 (-3.0A)
GTR  A 403 (-4.1A)
 1.00A 2jc9A-4ovrA:
undetectable		 2jc9A-4ovrA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 ASP A  99
THR A  52
ILE A  79
ASN A  76
 1VE  A 501 (-2.5A)
None
None
None
 1.14A 2jc9A-4oyaA:
undetectable		 2jc9A-4oyaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 THR A 784
ILE A 830
ASN A 831
GLN A 856
 None
 0.98A 2jc9A-4p2kA:
undetectable		 2jc9A-4p2kA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		4 ASP A 178
THR A 316
ILE A 237
ASN A  -6
 PO4  A 603 (-2.7A)
None
None
None
 1.28A 2jc9A-4pviA:
undetectable		 2jc9A-4pviA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16819
(DUF5074)
PF16820
(PKD_3) 		4 THR A 138
ASN A 448
PHE A 446
GLN A 403
 None
 1.27A 2jc9A-4r5oA:
undetectable		 2jc9A-4r5oA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		4 ASP A 368
ILE A 465
ASN A 463
PHE A 382
 None
 1.16A 2jc9A-4s13A:
undetectable		 2jc9A-4s13A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uap GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN

(Clostridium
perfringens) 		no annotation 4 ARG A  76
ASP A  39
THR A 140
ILE A  85
 NGA  A 201 (-2.7A)
None
NGA  A 201 ( 4.6A)
None
 1.15A 2jc9A-4uapA:
undetectable		 2jc9A-4uapA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		4 THR A 435
ILE A 439
ASN A 443
PHE A 440
 None
 1.18A 2jc9A-4xjxA:
undetectable		 2jc9A-4xjxA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(Geobacillus sp.
70PC53;
uncultured
bacterium) 		PF00150
(Cellulase) 		4 ARG A  30
ASP A 255
THR A 258
ASN A   9
 None
 1.08A 2jc9A-4xzwA:
1.9		 2jc9A-4xzwA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 4 ASP A 155
THR A 157
PHE A 142
GLN A 149
 None
 1.28A 2jc9A-5affA:
undetectable		 2jc9A-5affA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu9 BETA-N-ACETYLHEXOSAM
INIDASE

(Beutenbergia
cavernae) 		PF00933
(Glyco_hydro_3) 		4 ASP A 337
THR A 335
ILE A 363
PHE A  83
 None
 1.06A 2jc9A-5bu9A:
undetectable		 2jc9A-5bu9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 ASP A 353
THR A 356
ASN A 404
PHE A 407
 None
 1.01A 2jc9A-5d0fA:
undetectable		 2jc9A-5d0fA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed4 RESPONSE REGULATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 ARG A 133
ILE A 187
ASN A 188
GLN A  43
 None
 1.10A 2jc9A-5ed4A:
2.4		 2jc9A-5ed4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed4 RESPONSE REGULATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 THR A 180
ILE A 187
ASN A 188
GLN A  43
 None
 1.10A 2jc9A-5ed4A:
2.4		 2jc9A-5ed4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP B 460
THR B 401
ASN B 475
GLN B 529
 None
 0.98A 2jc9A-5fq6B:
undetectable		 2jc9A-5fq6B:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 ASP q  67
THR q  65
ILE h 524
ASN h 526
 None
 1.14A 2jc9A-5gw5q:
undetectable		 2jc9A-5gw5q:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		4 ASP A 461
THR A 357
ASN A 362
GLN A 501
 None
 0.85A 2jc9A-5kztA:
undetectable		 2jc9A-5kztA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx0 DIPEPTIDASE

(Aspergillus
fumigatus) 		PF01244
(Peptidase_M19) 		4 ARG A  57
ASP A  47
ASN A  24
PHE A  26
 None
 1.24A 2jc9A-5lx0A:
undetectable		 2jc9A-5lx0A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0j SWI5-DEPENDENT HO
EXPRESSION PROTEIN
2,SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3

(Saccharomyces
cerevisiae) 		no annotation 4 ASP D 227
ILE D 144
ASN D 114
PHE D 110
 None
 1.15A 2jc9A-5m0jD:
undetectable		 2jc9A-5m0jD:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ASP A 172
THR A 207
ILE A 179
ASN A 133
 None
 1.03A 2jc9A-5n28A:
2.1		 2jc9A-5n28A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ARG A 398
ILE A 396
ASN A 489
GLN A 517
 None
 1.20A 2jc9A-5oljA:
2.5		 2jc9A-5oljA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 ASP p  72
ILE p  24
ASN p  77
PHE p 117
 None
 1.21A 2jc9A-5optp:
undetectable		 2jc9A-5optp:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 4 ARG A 174
ASP A  37
ILE A  48
GLN A  47
 None
 1.24A 2jc9A-5tdxA:
1.8		 2jc9A-5tdxA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty7 PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		no annotation 4 ARG A 276
THR A 255
ILE A 281
ASN A  54
 None
 1.27A 2jc9A-5ty7A:
undetectable		 2jc9A-5ty7A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwg FRIZZLED-4

(Homo sapiens) 		PF01392
(Fz) 		4 ARG A  49
ASP A  46
THR A  61
ILE A  50
 None
 1.18A 2jc9A-5uwgA:
undetectable		 2jc9A-5uwgA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 4 ARG A 212
ASP A 217
ASN A 248
GLN A 273
 None
 1.03A 2jc9A-5wabA:
2.9		 2jc9A-5wabA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus) 		no annotation 4 ASP A  35
THR A 133
ILE A 101
ASN A  70
 None
 1.23A 2jc9A-5zu5A:
undetectable		 2jc9A-5zu5A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu6 CBM32 DOMAIN

(Vibrio) 		no annotation 4 ASP A  35
THR A 133
ILE A 101
ASN A  70
 None
 1.19A 2jc9A-5zu6A:
undetectable		 2jc9A-5zu6A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsp MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		no annotation 4 ARG C  30
ILE C 323
ASN C 320
PHE C 247
 None
 1.04A 2jc9A-6bspC:
undetectable		 2jc9A-6bspC:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 4 THR A 266
ILE A 286
PHE A  58
GLN A 237
 None
SAM  A 901 (-4.7A)
SAM  A 901 ( 3.5A)
SAM  A 901 (-3.0A)
 0.71A 2jc9A-6bxnA:
undetectable		 2jc9A-6bxnA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cah ABC TRANSPORTER
ATP-BINDING/PERMEASE
PROTEIN RV1747

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A 306
ASP A 296
THR A 291
ILE A 242
 None
 1.27A 2jc9A-6cahA:
undetectable		 2jc9A-6cahA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		no annotation 4 ASP L 372
THR L 345
ILE L 352
PHE L  25
 None
NFU  L 401 (-3.7A)
None
None
 1.06A 2jc9A-6cfwL:
2.5		 2jc9A-6cfwL:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
paracasei) 		no annotation 4 ARG A 196
ASP A 147
ASN A  71
PHE A  73
 TRS  A 401 (-2.7A)
None
TRS  A 401 (-3.0A)
None
 1.27A 2jc9A-6chkA:
undetectable		 2jc9A-6chkA:
10.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 4 ASP A 145
THR A 147
PHE A 354
GLN A 453
 None
None
None
PO4  A 602 (-4.1A)
 0.90A 2jc9A-6dd3A:
61.2		 2jc9A-6dd3A:
79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 5 THR A 147
ILE A 152
ASN A 154
PHE A 354
GLN A 453
 None
None
None
None
PO4  A 602 (-4.1A)
 0.70A 2jc9A-6dd3A:
61.2		 2jc9A-6dd3A:
79.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 ASP B 130
ILE B 147
ASN B 158
PHE B 150
 None
 1.28A 2jc9A-6evjB:
undetectable		 2jc9A-6evjB:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 THR B 469
ILE B 475
ASN B 306
GLN B 442
 None
 0.96A 2jc9A-6evjB:
undetectable		 2jc9A-6evjB:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 4 THR B 468
ILE B 474
ASN B 306
GLN B 441
 None
 0.73A 2jc9A-6f5oB:
3.0		 2jc9A-6f5oB:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 ARG A2094
ASP A2118
THR A2120
ILE A2096
 None
 1.19A 2jc9A-6fb3A:
undetectable		 2jc9A-6fb3A:
10.74