SIMILAR PATTERNS OF AMINO ACIDS FOR 2JB7_B_ACTB1169_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)

(Rattus
norvegicus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ARG A 163
ARG A 164
ARG A 122
 None
 1.16A 2jb7A-1bu8A:
0.3
2jb7B-1bu8A:
0.0
2jb7C-1bu8A:
0.4		 2jb7A-1bu8A:
16.23
2jb7B-1bu8A:
16.23
2jb7C-1bu8A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3b PROTEIN (SMALL
NUCLEAR
RIBONUCLEOPROTEIN SM
D3)
PROTEIN (SMALL
NUCLEAR
RIBONUCLEOPROTEIN
ASSOCIATED PROTEIN
B)

(Homo sapiens;
Homo sapiens) 		PF01423
(LSM)
PF01423
(LSM) 		3 ARG B  49
ARG B  65
ARG A  69
 GOL  B 611 (-4.2A)
None
GOL  B 608 (-4.0A)
 1.21A 2jb7A-1d3bB:
0.7
2jb7B-1d3bB:
0.7
2jb7C-1d3bB:
0.0		 2jb7A-1d3bB:
18.90
2jb7B-1d3bB:
18.90
2jb7C-1d3bB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3b PROTEIN (SMALL
NUCLEAR
RIBONUCLEOPROTEIN SM
D3)
PROTEIN (SMALL
NUCLEAR
RIBONUCLEOPROTEIN
ASSOCIATED PROTEIN
B)

(Homo sapiens;
Homo sapiens) 		PF01423
(LSM)
PF01423
(LSM) 		3 ARG B  65
ARG A  69
ARG B  49
 None
GOL  B 608 (-4.0A)
GOL  B 611 (-4.2A)
 1.20A 2jb7A-1d3bB:
0.7
2jb7B-1d3bB:
0.7
2jb7C-1d3bB:
0.0		 2jb7A-1d3bB:
18.90
2jb7B-1d3bB:
18.90
2jb7C-1d3bB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e41 FADD PROTEIN

(Homo sapiens) 		PF00531
(Death) 		3 ARG A 117
ARG A 114
ARG A 113
 None
 1.08A 2jb7A-1e41A:
0.0
2jb7B-1e41A:
0.0
2jb7C-1e41A:
0.0		 2jb7A-1e41A:
21.25
2jb7B-1e41A:
21.25
2jb7C-1e41A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I
ANTHRANILATE
SYNTHASE COMPONENT
II

(Salmonella
enterica;
Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
PF00117
(GATase) 		3 ARG A 375
ARG B  31
ARG A 117
 None
 1.12A 2jb7A-1i1qA:
1.8
2jb7B-1i1qA:
2.1
2jb7C-1i1qA:
1.9		 2jb7A-1i1qA:
15.31
2jb7B-1i1qA:
15.31
2jb7C-1i1qA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I
ANTHRANILATE
SYNTHASE COMPONENT
II

(Salmonella
enterica;
Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
PF00117
(GATase) 		3 ARG B  31
ARG A 117
ARG A 375
 None
 1.06A 2jb7A-1i1qB:
0.0
2jb7B-1i1qB:
0.0
2jb7C-1i1qB:
0.0		 2jb7A-1i1qB:
23.86
2jb7B-1i1qB:
23.86
2jb7C-1i1qB:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE
TRPG

(Serratia
marcescens;
Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
PF00117
(GATase) 		3 ARG A 375
ARG B  32
ARG A 117
 None
 1.13A 2jb7A-1i7qA:
1.0
2jb7B-1i7qA:
0.8
2jb7C-1i7qA:
0.9		 2jb7A-1i7qA:
15.46
2jb7B-1i7qA:
15.46
2jb7C-1i7qA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE
TRPG

(Serratia
marcescens;
Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
PF00117
(GATase) 		3 ARG B  32
ARG A 117
ARG A 375
 None
 1.09A 2jb7A-1i7qB:
0.0
2jb7B-1i7qB:
0.0
2jb7C-1i7qB:
0.0		 2jb7A-1i7qB:
22.44
2jb7B-1i7qB:
22.44
2jb7C-1i7qB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1s HYPOTHETICAL PROTEIN
MTH1491

(Methanothermobacter
thermautotrophicus) 		PF02635
(DrsE) 		3 ARG A  36
ARG A  68
ARG A 103
 None
 0.91A 2jb7A-1l1sA:
undetectable
2jb7B-1l1sA:
undetectable
2jb7C-1l1sA:
undetectable		 2jb7A-1l1sA:
23.35
2jb7B-1l1sA:
23.35
2jb7C-1l1sA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1s HYPOTHETICAL PROTEIN
MTH1491

(Methanothermobacter
thermautotrophicus) 		PF02635
(DrsE) 		3 ARG A  68
ARG A 103
ARG A  36
 None
 0.87A 2jb7A-1l1sA:
undetectable
2jb7B-1l1sA:
undetectable
2jb7C-1l1sA:
undetectable		 2jb7A-1l1sA:
23.35
2jb7B-1l1sA:
23.35
2jb7C-1l1sA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1s HYPOTHETICAL PROTEIN
MTH1491

(Methanothermobacter
thermautotrophicus) 		PF02635
(DrsE) 		3 ARG A 103
ARG A  36
ARG A  68
 None
 0.92A 2jb7A-1l1sA:
undetectable
2jb7B-1l1sA:
undetectable
2jb7C-1l1sA:
undetectable		 2jb7A-1l1sA:
23.35
2jb7B-1l1sA:
23.35
2jb7C-1l1sA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		3 ARG A 319
ARG A 323
ARG A 320
 None
 1.18A 2jb7A-1ocmA:
undetectable
2jb7B-1ocmA:
undetectable
2jb7C-1ocmA:
undetectable		 2jb7A-1ocmA:
18.50
2jb7B-1ocmA:
18.50
2jb7C-1ocmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		3 ARG A 320
ARG A 319
ARG A 323
 None
 1.21A 2jb7A-1ocmA:
undetectable
2jb7B-1ocmA:
undetectable
2jb7C-1ocmA:
undetectable		 2jb7A-1ocmA:
18.50
2jb7B-1ocmA:
18.50
2jb7C-1ocmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		3 ARG A 323
ARG A 320
ARG A 319
 None
 1.14A 2jb7A-1ocmA:
undetectable
2jb7B-1ocmA:
undetectable
2jb7C-1ocmA:
undetectable		 2jb7A-1ocmA:
18.50
2jb7B-1ocmA:
18.50
2jb7C-1ocmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ARG A 117
ARG A 127
ARG A 121
 None
 0.93A 2jb7A-1wydA:
undetectable
2jb7B-1wydA:
undetectable
2jb7C-1wydA:
undetectable		 2jb7A-1wydA:
18.74
2jb7B-1wydA:
18.74
2jb7C-1wydA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ARG A 121
ARG A 117
ARG A 127
 None
 0.93A 2jb7A-1wydA:
undetectable
2jb7B-1wydA:
undetectable
2jb7C-1wydA:
undetectable		 2jb7A-1wydA:
18.74
2jb7B-1wydA:
18.74
2jb7C-1wydA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ARG A 127
ARG A 121
ARG A 117
 None
 0.96A 2jb7A-1wydA:
undetectable
2jb7B-1wydA:
undetectable
2jb7C-1wydA:
undetectable		 2jb7A-1wydA:
18.74
2jb7B-1wydA:
18.74
2jb7C-1wydA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
DELTA CHAIN

(Homo sapiens;
Homo sapiens) 		PF16681
(Ig_5)
PF16680
(Ig_4) 		3 ARG A  94
ARG A  96
ARG B  42
 None
 1.12A 2jb7A-1xiwA:
undetectable
2jb7B-1xiwA:
undetectable
2jb7C-1xiwA:
undetectable		 2jb7A-1xiwA:
19.08
2jb7B-1xiwA:
19.08
2jb7C-1xiwA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
DELTA CHAIN

(Homo sapiens;
Homo sapiens) 		PF16681
(Ig_5)
PF16680
(Ig_4) 		3 ARG A  96
ARG B  42
ARG A  94
 None
 1.13A 2jb7A-1xiwA:
undetectable
2jb7B-1xiwA:
undetectable
2jb7C-1xiwA:
undetectable		 2jb7A-1xiwA:
19.08
2jb7B-1xiwA:
19.08
2jb7C-1xiwA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
DELTA CHAIN

(Homo sapiens;
Homo sapiens) 		PF16681
(Ig_5)
PF16680
(Ig_4) 		3 ARG B  42
ARG A  94
ARG A  96
 None
 1.14A 2jb7A-1xiwB:
undetectable
2jb7B-1xiwB:
undetectable
2jb7C-1xiwB:
undetectable		 2jb7A-1xiwB:
18.79
2jb7B-1xiwB:
18.79
2jb7C-1xiwB:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf5 TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN D

(Pseudomonas
mendocina) 		PF02406
(MmoB_DmpM) 		3 ARG A  18
ARG A  44
ARG A  45
 None
 0.99A 2jb7A-2bf5A:
1.8
2jb7B-2bf5A:
1.8
2jb7C-2bf5A:
2.2		 2jb7A-2bf5A:
21.02
2jb7B-2bf5A:
21.02
2jb7C-2bf5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf5 TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN D

(Pseudomonas
mendocina) 		PF02406
(MmoB_DmpM) 		3 ARG A  44
ARG A  45
ARG A  18
 None
 0.93A 2jb7A-2bf5A:
1.8
2jb7B-2bf5A:
1.8
2jb7C-2bf5A:
2.2		 2jb7A-2bf5A:
21.02
2jb7B-2bf5A:
21.02
2jb7C-2bf5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf5 TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN D

(Pseudomonas
mendocina) 		PF02406
(MmoB_DmpM) 		3 ARG A  45
ARG A  18
ARG A  44
 None
 0.98A 2jb7A-2bf5A:
1.8
2jb7B-2bf5A:
1.8
2jb7C-2bf5A:
2.2		 2jb7A-2bf5A:
21.02
2jb7B-2bf5A:
21.02
2jb7C-2bf5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		3 ARG A 722
ARG A 100
ARG A 720
 None
 1.16A 2jb7A-2btvA:
undetectable
2jb7B-2btvA:
undetectable
2jb7C-2btvA:
undetectable		 2jb7A-2btvA:
10.71
2jb7B-2btvA:
10.71
2jb7C-2btvA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0z NOVW

(Streptomyces
niveus) 		PF00908
(dTDP_sugar_isom) 		3 ARG A   2
ARG A 109
ARG A  -3
 None
EDO  A1192 (-4.1A)
EDO  A1192 (-4.0A)
 1.09A 2jb7A-2c0zA:
undetectable
2jb7B-2c0zA:
undetectable
2jb7C-2c0zA:
undetectable		 2jb7A-2c0zA:
21.30
2jb7B-2c0zA:
21.30
2jb7C-2c0zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0z NOVW

(Streptomyces
niveus) 		PF00908
(dTDP_sugar_isom) 		3 ARG A  -3
ARG A   2
ARG A 109
 EDO  A1192 (-4.0A)
None
EDO  A1192 (-4.1A)
 1.12A 2jb7A-2c0zA:
undetectable
2jb7B-2c0zA:
undetectable
2jb7C-2c0zA:
undetectable		 2jb7A-2c0zA:
21.30
2jb7B-2c0zA:
21.30
2jb7C-2c0zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0z NOVW

(Streptomyces
niveus) 		PF00908
(dTDP_sugar_isom) 		3 ARG A 109
ARG A  -3
ARG A   2
 EDO  A1192 (-4.1A)
EDO  A1192 (-4.0A)
None
 1.07A 2jb7A-2c0zA:
undetectable
2jb7B-2c0zA:
undetectable
2jb7C-2c0zA:
undetectable		 2jb7A-2c0zA:
21.30
2jb7B-2c0zA:
21.30
2jb7C-2c0zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h92 CYTIDYLATE KINASE

(Staphylococcus
aureus) 		PF02224
(Cytidylate_kin) 		3 ARG A  87
ARG A 153
ARG A 160
 C5P  A1300 ( 4.8A)
SO4  A1400 ( 3.6A)
None
 0.84A 2jb7A-2h92A:
undetectable
2jb7B-2h92A:
undetectable
2jb7C-2h92A:
undetectable		 2jb7A-2h92A:
21.92
2jb7B-2h92A:
21.92
2jb7C-2h92A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h92 CYTIDYLATE KINASE

(Staphylococcus
aureus) 		PF02224
(Cytidylate_kin) 		3 ARG A 153
ARG A 160
ARG A  87
 SO4  A1400 ( 3.6A)
None
C5P  A1300 ( 4.8A)
 0.82A 2jb7A-2h92A:
undetectable
2jb7B-2h92A:
undetectable
2jb7C-2h92A:
undetectable		 2jb7A-2h92A:
21.92
2jb7B-2h92A:
21.92
2jb7C-2h92A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h92 CYTIDYLATE KINASE

(Staphylococcus
aureus) 		PF02224
(Cytidylate_kin) 		3 ARG A 160
ARG A  87
ARG A 153
 None
C5P  A1300 ( 4.8A)
SO4  A1400 ( 3.6A)
 0.81A 2jb7A-2h92A:
undetectable
2jb7B-2h92A:
undetectable
2jb7C-2h92A:
undetectable		 2jb7A-2h92A:
21.92
2jb7B-2h92A:
21.92
2jb7C-2h92A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 ARG A 218
ARG A 245
ARG A 215
 None
 1.18A 2jb7A-2i7tA:
undetectable
2jb7B-2i7tA:
undetectable
2jb7C-2i7tA:
undetectable		 2jb7A-2i7tA:
17.79
2jb7B-2i7tA:
17.79
2jb7C-2i7tA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jml DNA BINDING
DOMAIN/TRANSCRIPTION
AL REGULATOR

(Myxococcus
xanthus) 		PF13411
(MerR_1) 		3 ARG A  51
ARG A  55
ARG A  52
 None
 1.20A 2jb7A-2jmlA:
undetectable
2jb7B-2jmlA:
undetectable
2jb7C-2jmlA:
undetectable		 2jb7A-2jmlA:
20.67
2jb7B-2jmlA:
20.67
2jb7C-2jmlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2

(Homo sapiens) 		PF03131
(bZIP_Maf) 		3 ARG A  23
ARG A  27
ARG A  71
 None
 0.96A 2jb7A-2lz1A:
undetectable
2jb7B-2lz1A:
undetectable
2jb7C-2lz1A:
undetectable		 2jb7A-2lz1A:
20.62
2jb7B-2lz1A:
20.62
2jb7C-2lz1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2

(Homo sapiens) 		PF03131
(bZIP_Maf) 		3 ARG A  27
ARG A  71
ARG A  23
 None
 1.00A 2jb7A-2lz1A:
undetectable
2jb7B-2lz1A:
undetectable
2jb7C-2lz1A:
undetectable		 2jb7A-2lz1A:
20.62
2jb7B-2lz1A:
20.62
2jb7C-2lz1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2

(Homo sapiens) 		PF03131
(bZIP_Maf) 		3 ARG A  71
ARG A  23
ARG A  27
 None
 1.03A 2jb7A-2lz1A:
undetectable
2jb7B-2lz1A:
undetectable
2jb7C-2lz1A:
undetectable		 2jb7A-2lz1A:
20.62
2jb7B-2lz1A:
20.62
2jb7C-2lz1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		3 ARG A  79
ARG A  83
ARG A  80
 None
 1.16A 2jb7A-2oerA:
undetectable
2jb7B-2oerA:
undetectable
2jb7C-2oerA:
undetectable		 2jb7A-2oerA:
21.82
2jb7B-2oerA:
21.82
2jb7C-2oerA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		3 ARG A  80
ARG A  79
ARG A  83
 None
 1.16A 2jb7A-2oerA:
undetectable
2jb7B-2oerA:
undetectable
2jb7C-2oerA:
undetectable		 2jb7A-2oerA:
21.82
2jb7B-2oerA:
21.82
2jb7C-2oerA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		3 ARG A  83
ARG A  80
ARG A  79
 None
 1.13A 2jb7A-2oerA:
undetectable
2jb7B-2oerA:
undetectable
2jb7C-2oerA:
undetectable		 2jb7A-2oerA:
21.82
2jb7B-2oerA:
21.82
2jb7C-2oerA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q47 PROBABLE
TYROSINE-PROTEIN
PHOSPHATASE
AT1G05000

(Arabidopsis
thaliana) 		PF03162
(Y_phosphatase2) 		3 ARG A 152
ARG A 188
ARG A 156
 SO4  A 204 ( 3.9A)
SO4  A 203 ( 4.2A)
SO4  A 203 (-3.7A)
 1.12A 2jb7A-2q47A:
undetectable
2jb7B-2q47A:
undetectable
2jb7C-2q47A:
undetectable		 2jb7A-2q47A:
18.34
2jb7B-2q47A:
18.34
2jb7C-2q47A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q47 PROBABLE
TYROSINE-PROTEIN
PHOSPHATASE
AT1G05000

(Arabidopsis
thaliana) 		PF03162
(Y_phosphatase2) 		3 ARG A 156
ARG A 152
ARG A 188
 SO4  A 203 (-3.7A)
SO4  A 204 ( 3.9A)
SO4  A 203 ( 4.2A)
 1.08A 2jb7A-2q47A:
undetectable
2jb7B-2q47A:
undetectable
2jb7C-2q47A:
undetectable		 2jb7A-2q47A:
18.34
2jb7B-2q47A:
18.34
2jb7C-2q47A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q47 PROBABLE
TYROSINE-PROTEIN
PHOSPHATASE
AT1G05000

(Arabidopsis
thaliana) 		PF03162
(Y_phosphatase2) 		3 ARG A 188
ARG A 156
ARG A 152
 SO4  A 203 ( 4.2A)
SO4  A 203 (-3.7A)
SO4  A 204 ( 3.9A)
 1.06A 2jb7A-2q47A:
undetectable
2jb7B-2q47A:
undetectable
2jb7C-2q47A:
undetectable		 2jb7A-2q47A:
18.34
2jb7B-2q47A:
18.34
2jb7C-2q47A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		3 ARG A 169
ARG A 371
ARG A 219
 U  F   1 ( 3.4A)
None
None
 0.83A 2jb7A-2vrtA:
undetectable
2jb7B-2vrtA:
undetectable
2jb7C-2vrtA:
undetectable		 2jb7A-2vrtA:
16.57
2jb7B-2vrtA:
16.57
2jb7C-2vrtA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		3 ARG A 219
ARG A 169
ARG A 371
 None
U  F   1 ( 3.4A)
None
 0.82A 2jb7A-2vrtA:
undetectable
2jb7B-2vrtA:
undetectable
2jb7C-2vrtA:
undetectable		 2jb7A-2vrtA:
16.57
2jb7B-2vrtA:
16.57
2jb7C-2vrtA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		3 ARG A 371
ARG A 219
ARG A 169
 None
None
U  F   1 ( 3.4A)
 0.80A 2jb7A-2vrtA:
undetectable
2jb7B-2vrtA:
undetectable
2jb7C-2vrtA:
undetectable		 2jb7A-2vrtA:
16.57
2jb7B-2vrtA:
16.57
2jb7C-2vrtA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 ARG A1439
ARG A1468
ARG A1470
 None
 0.98A 2jb7A-2vz9A:
undetectable
2jb7B-2vz9A:
undetectable
2jb7C-2vz9A:
undetectable		 2jb7A-2vz9A:
5.44
2jb7B-2vz9A:
5.44
2jb7C-2vz9A:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enu PUTATIVE
UNCHARACTERIZED
PROTEIN

(Nitrosospira
multiformis) 		PF08964
(Crystall_3) 		3 ARG A 107
ARG A 133
ARG A  74
 None
 1.09A 2jb7A-3enuA:
undetectable
2jb7B-3enuA:
undetectable
2jb7C-3enuA:
undetectable		 2jb7A-3enuA:
19.76
2jb7B-3enuA:
19.76
2jb7C-3enuA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869

(Streptomyces
coelicolor) 		PF01323
(DSBA) 		3 ARG A   2
ARG A  39
ARG A 189
 None
 0.96A 2jb7A-3gl5A:
undetectable
2jb7B-3gl5A:
undetectable
2jb7C-3gl5A:
undetectable		 2jb7A-3gl5A:
21.46
2jb7B-3gl5A:
21.46
2jb7C-3gl5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869

(Streptomyces
coelicolor) 		PF01323
(DSBA) 		3 ARG A  39
ARG A 189
ARG A   2
 None
 1.00A 2jb7A-3gl5A:
undetectable
2jb7B-3gl5A:
undetectable
2jb7C-3gl5A:
undetectable		 2jb7A-3gl5A:
21.46
2jb7B-3gl5A:
21.46
2jb7C-3gl5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869

(Streptomyces
coelicolor) 		PF01323
(DSBA) 		3 ARG A 189
ARG A   2
ARG A  39
 None
 0.99A 2jb7A-3gl5A:
undetectable
2jb7B-3gl5A:
undetectable
2jb7C-3gl5A:
undetectable		 2jb7A-3gl5A:
21.46
2jb7B-3gl5A:
21.46
2jb7C-3gl5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		3 ARG A 173
ARG A 298
ARG A 296
 None
 0.81A 2jb7A-3m6xA:
undetectable
2jb7B-3m6xA:
0.2
2jb7C-3m6xA:
undetectable		 2jb7A-3m6xA:
15.52
2jb7B-3m6xA:
15.52
2jb7C-3m6xA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		3 ARG A 296
ARG A 173
ARG A 298
 None
 0.75A 2jb7A-3m6xA:
undetectable
2jb7B-3m6xA:
0.2
2jb7C-3m6xA:
undetectable		 2jb7A-3m6xA:
15.52
2jb7B-3m6xA:
15.52
2jb7C-3m6xA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		3 ARG A 298
ARG A 296
ARG A 173
 None
 0.77A 2jb7A-3m6xA:
undetectable
2jb7B-3m6xA:
0.2
2jb7C-3m6xA:
undetectable		 2jb7A-3m6xA:
15.52
2jb7B-3m6xA:
15.52
2jb7C-3m6xA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER

(Homo sapiens) 		PF00069
(Pkinase)
PF08332
(CaMKII_AD) 		3 ARG A 403
ARG A 439
ARG A 423
 None
 1.20A 2jb7A-3soaA:
undetectable
2jb7B-3soaA:
undetectable
2jb7C-3soaA:
undetectable		 2jb7A-3soaA:
17.01
2jb7B-3soaA:
17.01
2jb7C-3soaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 ARG A 344
ARG A 392
ARG A 399
 None
 1.12A 2jb7A-3ulzA:
undetectable
2jb7B-3ulzA:
undetectable
2jb7C-3ulzA:
undetectable		 2jb7A-3ulzA:
18.07
2jb7B-3ulzA:
18.07
2jb7C-3ulzA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 ARG A 392
ARG A 399
ARG A 344
 None
 1.12A 2jb7A-3ulzA:
undetectable
2jb7B-3ulzA:
undetectable
2jb7C-3ulzA:
undetectable		 2jb7A-3ulzA:
18.07
2jb7B-3ulzA:
18.07
2jb7C-3ulzA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 ARG A 399
ARG A 344
ARG A 392
 None
 1.11A 2jb7A-3ulzA:
undetectable
2jb7B-3ulzA:
undetectable
2jb7C-3ulzA:
undetectable		 2jb7A-3ulzA:
18.07
2jb7B-3ulzA:
18.07
2jb7C-3ulzA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 ARG A 228
ARG A 264
ARG A 142
 SO4  A1338 (-3.1A)
SO4  A1338 ( 3.7A)
SO4  A1338 (-3.3A)
 1.20A 2jb7A-4btmA:
undetectable
2jb7B-4btmA:
undetectable
2jb7C-4btmA:
undetectable		 2jb7A-4btmA:
18.48
2jb7B-4btmA:
18.48
2jb7C-4btmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu FAB 8M2 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG H  38
ARG H  62
ARG H  66
 None
 1.02A 2jb7A-4hfuH:
undetectable
2jb7B-4hfuH:
undetectable
2jb7C-4hfuH:
undetectable		 2jb7A-4hfuH:
19.91
2jb7B-4hfuH:
19.91
2jb7C-4hfuH:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu FAB 8M2 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG H  66
ARG H  38
ARG H  62
 None
 1.01A 2jb7A-4hfuH:
undetectable
2jb7B-4hfuH:
undetectable
2jb7C-4hfuH:
undetectable		 2jb7A-4hfuH:
19.91
2jb7B-4hfuH:
19.91
2jb7C-4hfuH:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		3 ARG A 223
ARG A 304
ARG A 247
 None
 0.83A 2jb7A-4kw5A:
undetectable
2jb7B-4kw5A:
undetectable
2jb7C-4kw5A:
undetectable		 2jb7A-4kw5A:
16.56
2jb7B-4kw5A:
16.56
2jb7C-4kw5A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		3 ARG A 247
ARG A 223
ARG A 304
 None
 0.80A 2jb7A-4kw5A:
undetectable
2jb7B-4kw5A:
undetectable
2jb7C-4kw5A:
undetectable		 2jb7A-4kw5A:
16.56
2jb7B-4kw5A:
16.56
2jb7C-4kw5A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		3 ARG A 304
ARG A 247
ARG A 223
 None
 0.81A 2jb7A-4kw5A:
undetectable
2jb7B-4kw5A:
undetectable
2jb7C-4kw5A:
undetectable		 2jb7A-4kw5A:
16.56
2jb7B-4kw5A:
16.56
2jb7C-4kw5A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p29 LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		3 ARG A 170
ARG A  75
ARG A  71
 SO4  A 301 (-3.6A)
SO4  A 301 (-4.4A)
SO4  A 301 (-3.6A)
 1.15A 2jb7A-4p29A:
undetectable
2jb7B-4p29A:
undetectable
2jb7C-4p29A:
undetectable		 2jb7A-4p29A:
20.58
2jb7B-4p29A:
20.58
2jb7C-4p29A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 3 ARG B 284
ARG B 380
ARG B 373
 None
 1.20A 2jb7A-4ritB:
undetectable
2jb7B-4ritB:
0.3
2jb7C-4ritB:
0.2		 2jb7A-4ritB:
18.01
2jb7B-4ritB:
18.01
2jb7C-4ritB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 3 ARG B 373
ARG B 284
ARG B 380
 None
 1.18A 2jb7A-4ritB:
undetectable
2jb7B-4ritB:
0.3
2jb7C-4ritB:
0.2		 2jb7A-4ritB:
18.01
2jb7B-4ritB:
18.01
2jb7C-4ritB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 3 ARG B 380
ARG B 373
ARG B 284
 None
 1.17A 2jb7A-4ritB:
undetectable
2jb7B-4ritB:
0.3
2jb7C-4ritB:
0.2		 2jb7A-4ritB:
18.01
2jb7B-4ritB:
18.01
2jb7C-4ritB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 3 ARG A  36
ARG A 182
ARG A 228
 None
 1.15A 2jb7A-4txdA:
undetectable
2jb7B-4txdA:
2.5
2jb7C-4txdA:
2.4		 2jb7A-4txdA:
23.27
2jb7B-4txdA:
23.27
2jb7C-4txdA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 3 ARG A 182
ARG A 228
ARG A  36
 None
 1.17A 2jb7A-4txdA:
undetectable
2jb7B-4txdA:
2.5
2jb7C-4txdA:
2.4		 2jb7A-4txdA:
23.27
2jb7B-4txdA:
23.27
2jb7C-4txdA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 3 ARG A 228
ARG A  36
ARG A 182
 None
 1.17A 2jb7A-4txdA:
undetectable
2jb7B-4txdA:
2.5
2jb7C-4txdA:
2.4		 2jb7A-4txdA:
23.27
2jb7B-4txdA:
23.27
2jb7C-4txdA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		3 ARG A  28
ARG A 154
ARG A 152
 3GP  A 402 ( 4.9A)
PO4  A 401 ( 3.2A)
PO4  A 401 (-3.5A)
 1.19A 2jb7A-4w8xA:
undetectable
2jb7B-4w8xA:
1.7
2jb7C-4w8xA:
1.7		 2jb7A-4w8xA:
19.58
2jb7B-4w8xA:
19.58
2jb7C-4w8xA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		3 ARG A 154
ARG A 152
ARG A  28
 PO4  A 401 ( 3.2A)
PO4  A 401 (-3.5A)
3GP  A 402 ( 4.9A)
 1.20A 2jb7A-4w8xA:
undetectable
2jb7B-4w8xA:
1.7
2jb7C-4w8xA:
1.7		 2jb7A-4w8xA:
19.58
2jb7B-4w8xA:
19.58
2jb7C-4w8xA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 3 ARG D 362
ARG D 366
ARG D 363
 None
 1.02A 2jb7A-4x28D:
undetectable
2jb7B-4x28D:
undetectable
2jb7C-4x28D:
undetectable		 2jb7A-4x28D:
17.02
2jb7B-4x28D:
17.02
2jb7C-4x28D:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 3 ARG D 363
ARG D 362
ARG D 366
 None
 1.05A 2jb7A-4x28D:
undetectable
2jb7B-4x28D:
undetectable
2jb7C-4x28D:
undetectable		 2jb7A-4x28D:
17.02
2jb7B-4x28D:
17.02
2jb7C-4x28D:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 3 ARG D 366
ARG D 363
ARG D 362
 None
 1.00A 2jb7A-4x28D:
undetectable
2jb7B-4x28D:
undetectable
2jb7C-4x28D:
undetectable		 2jb7A-4x28D:
17.02
2jb7B-4x28D:
17.02
2jb7C-4x28D:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		3 ARG A  41
ARG A 177
ARG A 181
 FLC  A 501 (-2.5A)
FLC  A 501 (-2.4A)
None
 0.94A 2jb7A-4x4wA:
undetectable
2jb7B-4x4wA:
undetectable
2jb7C-4x4wA:
undetectable		 2jb7A-4x4wA:
18.58
2jb7B-4x4wA:
18.58
2jb7C-4x4wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		3 ARG A 177
ARG A 181
ARG A  41
 FLC  A 501 (-2.4A)
None
FLC  A 501 (-2.5A)
 0.94A 2jb7A-4x4wA:
undetectable
2jb7B-4x4wA:
undetectable
2jb7C-4x4wA:
undetectable		 2jb7A-4x4wA:
18.58
2jb7B-4x4wA:
18.58
2jb7C-4x4wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		3 ARG A 181
ARG A  41
ARG A 177
 None
FLC  A 501 (-2.5A)
FLC  A 501 (-2.4A)
 0.85A 2jb7A-4x4wA:
undetectable
2jb7B-4x4wA:
undetectable
2jb7C-4x4wA:
undetectable		 2jb7A-4x4wA:
18.58
2jb7B-4x4wA:
18.58
2jb7C-4x4wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 ARG A  20
ARG A 124
ARG A 388
 None
 1.14A 2jb7A-5dl6A:
undetectable
2jb7B-5dl6A:
undetectable
2jb7C-5dl6A:
undetectable		 2jb7A-5dl6A:
16.02
2jb7B-5dl6A:
16.02
2jb7C-5dl6A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 ARG A 124
ARG A 388
ARG A  20
 None
 1.15A 2jb7A-5dl6A:
undetectable
2jb7B-5dl6A:
undetectable
2jb7C-5dl6A:
undetectable		 2jb7A-5dl6A:
16.02
2jb7B-5dl6A:
16.02
2jb7C-5dl6A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 ARG A 388
ARG A  20
ARG A 124
 None
 1.18A 2jb7A-5dl6A:
undetectable
2jb7B-5dl6A:
undetectable
2jb7C-5dl6A:
undetectable		 2jb7A-5dl6A:
16.02
2jb7B-5dl6A:
16.02
2jb7C-5dl6A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jia RAN-BINDING PROTEIN
10

(Mus musculus) 		PF00622
(SPRY) 		3 ARG A  37
ARG A  41
ARG A  38
 None
 0.96A 2jb7A-5jiaA:
undetectable
2jb7B-5jiaA:
undetectable
2jb7C-5jiaA:
undetectable		 2jb7A-5jiaA:
18.89
2jb7B-5jiaA:
18.89
2jb7C-5jiaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jia RAN-BINDING PROTEIN
10

(Mus musculus) 		PF00622
(SPRY) 		3 ARG A  38
ARG A  37
ARG A  41
 None
 1.03A 2jb7A-5jiaA:
undetectable
2jb7B-5jiaA:
undetectable
2jb7C-5jiaA:
undetectable		 2jb7A-5jiaA:
18.89
2jb7B-5jiaA:
18.89
2jb7C-5jiaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jia RAN-BINDING PROTEIN
10

(Mus musculus) 		PF00622
(SPRY) 		3 ARG A  41
ARG A  38
ARG A  37
 None
 0.94A 2jb7A-5jiaA:
undetectable
2jb7B-5jiaA:
undetectable
2jb7C-5jiaA:
undetectable		 2jb7A-5jiaA:
18.89
2jb7B-5jiaA:
18.89
2jb7C-5jiaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		3 ARG A 331
ARG A 324
ARG A 277
 None
 1.08A 2jb7A-5jrjA:
undetectable
2jb7B-5jrjA:
undetectable
2jb7C-5jrjA:
undetectable		 2jb7A-5jrjA:
18.26
2jb7B-5jrjA:
18.26
2jb7C-5jrjA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		3 ARG 5 162
ARG 5 350
ARG 5 173
 A  A2394 ( 3.7A)
A  A2395 ( 3.1A)
A  A2395 ( 3.0A)
 1.17A 2jb7A-5ool5:
undetectable
2jb7B-5ool5:
undetectable
2jb7C-5ool5:
undetectable		 2jb7A-5ool5:
18.03
2jb7B-5ool5:
18.03
2jb7C-5ool5:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		3 ARG 5 173
ARG 5 162
ARG 5 350
 A  A2395 ( 3.0A)
A  A2394 ( 3.7A)
A  A2395 ( 3.1A)
 1.15A 2jb7A-5ool5:
undetectable
2jb7B-5ool5:
undetectable
2jb7C-5ool5:
undetectable		 2jb7A-5ool5:
18.03
2jb7B-5ool5:
18.03
2jb7C-5ool5:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		3 ARG 5 350
ARG 5 173
ARG 5 162
 A  A2395 ( 3.1A)
A  A2395 ( 3.0A)
A  A2394 ( 3.7A)
 1.17A 2jb7A-5ool5:
undetectable
2jb7B-5ool5:
undetectable
2jb7C-5ool5:
undetectable		 2jb7A-5ool5:
18.03
2jb7B-5ool5:
18.03
2jb7C-5ool5:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ARG 2 854
ARG 2 858
ARG 2 855
 None
 0.86A 2jb7A-5udb2:
undetectable
2jb7B-5udb2:
undetectable
2jb7C-5udb2:
undetectable		 2jb7A-5udb2:
11.38
2jb7B-5udb2:
11.38
2jb7C-5udb2:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ARG 2 855
ARG 2 854
ARG 2 858
 None
 0.86A 2jb7A-5udb2:
undetectable
2jb7B-5udb2:
undetectable
2jb7C-5udb2:
undetectable		 2jb7A-5udb2:
11.38
2jb7B-5udb2:
11.38
2jb7C-5udb2:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ARG 2 858
ARG 2 855
ARG 2 854
 None
 0.90A 2jb7A-5udb2:
undetectable
2jb7B-5udb2:
undetectable
2jb7C-5udb2:
undetectable		 2jb7A-5udb2:
11.38
2jb7B-5udb2:
11.38
2jb7C-5udb2:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 3 ARG A 484
ARG A 491
ARG A 495
 None
 1.05A 2jb7A-6b6lA:
undetectable
2jb7B-6b6lA:
undetectable
2jb7C-6b6lA:
undetectable		 2jb7A-6b6lA:
12.71
2jb7B-6b6lA:
12.71
2jb7C-6b6lA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 3 ARG A 491
ARG A 495
ARG A 484
 None
 1.12A 2jb7A-6b6lA:
undetectable
2jb7B-6b6lA:
undetectable
2jb7C-6b6lA:
undetectable		 2jb7A-6b6lA:
12.71
2jb7B-6b6lA:
12.71
2jb7C-6b6lA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 3 ARG A 495
ARG A 484
ARG A 491
 None
 1.07A 2jb7A-6b6lA:
undetectable
2jb7B-6b6lA:
undetectable
2jb7C-6b6lA:
undetectable		 2jb7A-6b6lA:
12.71
2jb7B-6b6lA:
12.71
2jb7C-6b6lA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 3 ARG A   8
ARG A 135
ARG A  43
 None
 1.07A 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable		 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 3 ARG A  43
ARG A   8
ARG A 135
 None
 1.09A 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable		 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 3 ARG A 135
ARG A  43
ARG A   8
 None
 1.15A 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable		 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f49 -

(-) 		no annotation 3 ARG A 182
ARG A 210
ARG A 213
 None
 1.02A 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable		 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f49 -

(-) 		no annotation 3 ARG A 210
ARG A 213
ARG A 182
 None
 1.07A 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable		 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f49 -

(-) 		no annotation 3 ARG A 213
ARG A 182
ARG A 210
 None
 1.09A 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable		 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN
VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG

(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		no annotation
no annotation 		3 ARG C 102
ARG A  29
ARG C  94
 None
 1.18A 2jb7A-6feaC:
undetectable
2jb7B-6feaC:
undetectable
2jb7C-6feaC:
undetectable		 2jb7A-6feaC:
undetectable
2jb7B-6feaC:
undetectable
2jb7C-6feaC:
undetectable