SIMILAR PATTERNS OF AMINO ACIDS FOR 2JAP_C_J01C1249_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk2 DNA POLYMERASE BETA

(Rattus
norvegicus) 		PF14716
(HHH_8) 		5 LEU A  19
ILE A  53
ALA A  59
VAL A  45
ALA A  42
 None
 1.15A 2japC-1dk2A:
undetectable		 2japC-1dk2A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2z CYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 LEU A  83
VAL A  89
ALA A  84
LEU A  75
TYR A 102
 None
 1.03A 2japC-1e2zA:
undetectable		 2japC-1e2zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fb5 ORNITHINE
TRANSCARBAMOYLASE

(Ovis aries) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  59
ILE A  67
ALA A 336
LEU A 349
TYR A 345
 None
 1.12A 2japC-1fb5A:
5.1		 2japC-1fb5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij9 VASCULAR CELL
ADHESION PROTEIN 1

(Homo sapiens) 		PF05790
(C2-set)
PF07679
(I-set) 		5 MET A  58
LEU A  21
ILE A  88
ALA A  13
TYR A  69
 None
 1.19A 2japC-1ij9A:
undetectable		 2japC-1ij9A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 LEU A 417
ILE A 672
ALA A 486
ALA A 397
LEU A 393
 None
 1.20A 2japC-1o94A:
3.3		 2japC-1o94A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 LEU A  39
ILE A 219
ALA A 387
ALA A  54
LEU A 357
 None
 1.20A 2japC-1pieA:
undetectable		 2japC-1pieA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7l AMINOACYLASE-1

(Homo sapiens) 		PF01546
(Peptidase_M20) 		5 LEU B 398
ILE B 390
VAL B 330
ALA B 397
LEU A  77
 None
 1.19A 2japC-1q7lB:
undetectable		 2japC-1q7lB:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 LEU A  83
VAL A  89
ALA A  84
LEU A  75
TYR A 102
 None
 0.97A 2japC-1q90A:
undetectable		 2japC-1q90A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhl PROTEIN (CELL
DIVISION PROTEIN
MUKB)

(Escherichia
coli) 		PF04310
(MukB) 		5 LEU A  90
ALA A  46
ALA A  50
THR A  22
LEU A  28
 None
 1.19A 2japC-1qhlA:
undetectable		 2japC-1qhlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		5 LEU A  93
SER A  31
ILE A  75
ALA A  92
LEU A  24
 None
 1.26A 2japC-1sivA:
undetectable		 2japC-1sivA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		5 LEU A   8
VAL A 234
ALA A 236
TYR A 186
LEU A 111
 None
 1.25A 2japC-1txoA:
undetectable		 2japC-1txoA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU A 200
ILE A 258
VAL A 195
ALA A 192
LEU A 217
 None
 1.19A 2japC-1v0bA:
undetectable		 2japC-1v0bA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		5 LEU 1 300
ILE 1 344
VAL 1 239
THR 1 229
LEU 1 226
 None
 1.05A 2japC-1wao1:
undetectable		 2japC-1wao1:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 223
SER A 211
VAL A 231
THR A 239
LEU A 197
 None
 1.09A 2japC-1xecA:
undetectable		 2japC-1xecA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		5 LEU A  38
ILE A  68
ALA A 110
LEU A 163
TYR A  25
 None
None
None
SAH  A4001 (-4.5A)
SAH  A4001 (-4.4A)
 1.19A 2japC-2a14A:
6.0		 2japC-2a14A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		5 ILE A 242
ALA A 159
VAL A 165
ALA A 139
LEU A 260
 None
 1.17A 2japC-2c3oA:
3.0		 2japC-2c3oA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2co6 PUTATIVE FIMBRIAE
ASSEMBLY CHAPERONE

(Salmonella
enterica) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		5 LEU B  16
ILE B  42
ALA B  99
ALA B 124
LEU B  76
 None
 1.22A 2japC-2co6B:
undetectable		 2japC-2co6B:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A  78
VAL A  26
ALA A  30
THR A  88
LEU A 210
 None
 1.01A 2japC-2cx9A:
undetectable		 2japC-2cx9A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 LEU A 212
ALA A 109
VAL A 120
ALA A 113
LEU A 235
 None
 1.13A 2japC-2d0dA:
5.5		 2japC-2d0dA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkn 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Pseudomonas sp.
B-0831) 		PF13561
(adh_short_C2) 		5 SER A 114
ILE A 115
ALA A 116
TYR A 153
LEU A 190
 NAI  A4000 (-3.5A)
None
None
NAI  A4000 (-4.8A)
NAI  A4000 (-3.7A)
 0.50A 2japC-2dknA:
25.6		 2japC-2dknA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjc ANTIGEN TPF1

(Treponema
pallidum) 		PF00210
(Ferritin) 		5 LEU A  53
ILE A 168
ALA A 167
TYR A  75
LEU A 124
 None
 1.16A 2japC-2fjcA:
undetectable		 2japC-2fjcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		5 SER A 135
ILE A 136
ALA A 137
TYR A 159
THR A 188
 None
 0.79A 2japC-2hrzA:
5.6		 2japC-2hrzA:
24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jah CLAVULANIC ACID
DEHYDROGENASE

(Streptomyces
clavuligerus) 		PF00106
(adh_short) 		7 MET A  95
LEU A  97
ALA A 152
TYR A 155
LEU A 192
TYR A 205
ARG A 208
 None
None
None
NDP  A1248 (-4.7A)
NDP  A1248 (-3.5A)
None
None
 1.19A 2japC-2jahA:
46.5		 2japC-2jahA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jah CLAVULANIC ACID
DEHYDROGENASE

(Streptomyces
clavuligerus) 		PF00106
(adh_short) 		11 MET A  95
LEU A  97
SER A 142
ILE A 143
ALA A 144
VAL A 149
ALA A 152
TYR A 155
THR A 187
LEU A 192
TYR A 205
 None
None
NDP  A1248 (-3.3A)
None
None
None
None
NDP  A1248 (-4.7A)
NDP  A1248 (-4.6A)
NDP  A1248 (-3.5A)
None
 0.13A 2japC-2jahA:
46.5		 2japC-2jahA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 LEU A  83
ALA A 100
TYR A  97
LEU A  42
TYR A  79
 None
 1.23A 2japC-2okcA:
5.8		 2japC-2okcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olg PRO-PHENOLOXIDASE
ACTIVATING ENZYME-I

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		5 LEU A 162
ILE A 201
ALA A 167
TYR A 129
THR A 204
 None
 1.25A 2japC-2olgA:
undetectable		 2japC-2olgA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 MET A  40
LEU A  99
ILE A 238
ALA A 239
TYR A  33
 None
None
EDO  A 295 (-4.1A)
None
None
 1.20A 2japC-2r9lA:
undetectable		 2japC-2r9lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6y AAA FAMILY ATPASE,
P60 KATANIN

(Sulfolobus
solfataricus) 		PF04212
(MIT) 		5 MET B  60
LEU B  41
ILE B  16
ALA B  15
TYR B  64
 None
 1.23A 2japC-2v6yB:
undetectable		 2japC-2v6yB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		5 MET A  95
LEU A  92
ILE A 291
ALA A 120
THR A 309
 None
 1.22A 2japC-2w48A:
undetectable		 2japC-2w48A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9q CYCLODIPEPTIDE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF16715
(CDPS) 		5 ILE A 144
ALA A 140
TYR A 126
THR A 118
TYR A 229
 None
 1.11A 2japC-2x9qA:
3.2		 2japC-2x9qA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 SER A 163
VAL A 204
ALA A 189
TYR A 192
LEU A  79
 None
 1.18A 2japC-2xdrA:
5.4		 2japC-2xdrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zup DISULFIDE BOND
FORMATION PROTEIN B

(Escherichia
coli) 		PF02600
(DsbB) 		5 ILE B  63
ALA B  14
VAL B 161
ALA B 157
LEU B  55
 None
 1.13A 2japC-2zupB:
undetectable		 2japC-2zupB:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 5 ILE A 143
ALA A 140
ALA A 136
LEU A 111
TYR A  36
 None
 1.14A 2japC-3cvoA:
6.8		 2japC-3cvoA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 SER A 771
ILE A 733
ALA A 735
TYR A 664
ARG A 746
 None
 1.27A 2japC-3ecqA:
undetectable		 2japC-3ecqA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		5 MET A  45
LEU A  42
ILE A 241
ALA A  70
THR A 259
 None
 1.20A 2japC-3efbA:
undetectable		 2japC-3efbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		5 ILE A 149
VAL A 110
ALA A 108
TYR A 245
LEU A 188
 None
 1.10A 2japC-3ez6A:
2.9		 2japC-3ez6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		5 LEU A 130
VAL A 140
ALA A 129
LEU A 206
TYR A 198
 None
 1.25A 2japC-3htxA:
6.5		 2japC-3htxA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k20 OXIDOREDUCTASE

(Corynebacterium
diphtheriae) 		PF03358
(FMN_red) 		5 MET A 137
LEU A 106
ILE A 100
ALA A 105
LEU A 133
 None
 1.17A 2japC-3k20A:
5.0		 2japC-3k20A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 MET A  96
LEU A 102
ALA A  10
VAL A   7
ALA A  18
 None
 1.26A 2japC-3l8kA:
3.8		 2japC-3l8kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Streptococcus
agalactiae) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 351
ILE A 334
ALA A 424
VAL A 385
ALA A 353
 None
 1.13A 2japC-3lk7A:
2.5		 2japC-3lk7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP

(Vibrio cholerae) 		PF01554
(MatE) 		5 ILE A 343
ALA A 344
VAL A 279
ALA A 357
THR A 336
 None
 1.26A 2japC-3mktA:
undetectable		 2japC-3mktA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwc SMC PROTEIN

(Pyrococcus
furiosus) 		PF06470
(SMC_hinge) 		5 LEU A 575
SER A 517
ILE A 519
VAL A 554
LEU A 572
 None
 1.14A 2japC-3nwcA:
undetectable		 2japC-3nwcA:
27.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p19 PUTATIVE BLUE
FLUORESCENT PROTEIN

(Vibrio
vulnificus) 		PF00106
(adh_short) 		7 MET A  84
LEU A  86
SER A 132
ALA A 134
TYR A 145
LEU A 182
TYR A 195
 None
None
NDP  A2001 ( 3.5A)
None
NDP  A2001 ( 4.7A)
NDP  A2001 ( 3.5A)
None
 0.48A 2japC-3p19A:
22.2		 2japC-3p19A:
39.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p19 PUTATIVE BLUE
FLUORESCENT PROTEIN

(Vibrio
vulnificus) 		PF00106
(adh_short) 		6 SER A 132
ILE A 133
ALA A 134
TYR A 145
LEU A 182
TYR A 195
 NDP  A2001 ( 3.5A)
None
None
NDP  A2001 ( 4.7A)
NDP  A2001 ( 3.5A)
None
 0.75A 2japC-3p19A:
22.2		 2japC-3p19A:
39.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 SER A 152
ILE A 153
ALA A 154
TYR A 165
THR A 197
 None
 0.88A 2japC-3ppiA:
29.7		 2japC-3ppiA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 266
ILE A 314
ALA A 308
ALA A 304
LEU A 276
 None
 1.17A 2japC-3q4dA:
2.1		 2japC-3q4dA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6o 2-HYDROXYHEPTA-2,4-D
IENE-1,
7-DIOATEISOMERASE

(Mycobacteroides
abscessus) 		PF01557
(FAA_hydrolase) 		5 ILE A 259
VAL A 160
ALA A 156
THR A 261
LEU A 238
 None
 1.07A 2japC-3r6oA:
undetectable		 2japC-3r6oA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbu HYPOTHETICAL
NTF2-LIKE PROTEIN

(Bacteroides
fragilis) 		PF14254
(DUF4348) 		5 LEU A 116
ILE A  68
VAL A 137
TYR A 114
TYR A 239
 None
None
None
MLY  A 255 ( 4.0A)
GOL  A 289 (-4.8A)
 1.26A 2japC-3sbuA:
undetectable		 2japC-3sbuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smv S-(-)-AZETIDINE-2-CA
RBOXYLATE HYDROLASE

(Pseudomonas sp.
AC2) 		PF13419
(HAD_2) 		5 LEU A 111
ALA A 233
THR A   4
LEU A 176
TYR A 115
 None
 1.20A 2japC-3smvA:
6.1		 2japC-3smvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		5 ILE C  55
ALA C  32
VAL C 159
ALA C 157
TYR C  42
 None
 1.16A 2japC-3t6qC:
undetectable		 2japC-3t6qC:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		7 MET A  92
LEU A  94
SER A 140
ILE A 141
VAL A 147
ALA A 150
TYR A 153
 None
 0.65A 2japC-3tfoA:
34.4		 2japC-3tfoA:
38.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		5 LEU A 129
ILE A 230
ALA A 167
ALA A 226
LEU A 240
 None
 1.23A 2japC-3uf6A:
6.9		 2japC-3uf6A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ALA A 213
VAL A 192
ALA A 249
TYR A 246
LEU A 280
 None
 1.22A 2japC-3uszA:
2.1		 2japC-3uszA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN BETA
SUBUNIT

(Porphyridium
purpureum) 		PF00502
(Phycobilisome) 		5 SER B  43
ILE B  44
ALA B  40
VAL B 165
ALA B 162
 None
None
PEB  B 204 ( 4.0A)
None
None
 1.23A 2japC-3v57B:
undetectable		 2japC-3v57B:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		5 LEU A  78
ILE A 330
ALA A 329
ALA A  93
LEU A 200
 None
 1.14A 2japC-4au2A:
undetectable		 2japC-4au2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 304
SER A 380
ALA A 390
ALA A 303
LEU A 334
 None
 1.17A 2japC-4c2kA:
undetectable		 2japC-4c2kA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fn4 SHORT CHAIN
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF13561
(adh_short_C2) 		5 LEU A 210
SER A 145
ILE A 146
ALA A 147
THR A 190
 None
NAD  A 501 (-3.6A)
None
None
None
 0.97A 2japC-4fn4A:
34.1		 2japC-4fn4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fn4 SHORT CHAIN
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF13561
(adh_short_C2) 		5 SER A 145
ILE A 146
ALA A 147
TYR A 158
THR A 190
 NAD  A 501 (-3.6A)
None
None
GOL  A 502 ( 4.3A)
None
 0.65A 2japC-4fn4A:
34.1		 2japC-4fn4A:
31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		5 LEU A 252
ILE A 184
ALA A 213
ALA A 222
TYR A 256
 None
 1.18A 2japC-4kemA:
3.1		 2japC-4kemA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		5 SER A 234
VAL A 163
TYR A 158
LEU A 211
TYR A 184
 None
None
ACY  A 401 (-3.4A)
None
None
 1.15A 2japC-4mptA:
2.9		 2japC-4mptA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		5 LEU A 258
SER A 242
ILE A 221
ALA A 244
TYR A 273
 None
 1.26A 2japC-4rk1A:
7.4		 2japC-4rk1A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		5 LEU A  96
ILE A 151
ALA A 152
ALA A 161
THR A 196
 None
 1.04A 2japC-4tkmA:
29.8		 2japC-4tkmA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		6 SER A 150
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 0.59A 2japC-4tkmA:
29.8		 2japC-4tkmA:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 LEU A  39
ILE A 104
ALA A 213
ALA A  38
LEU A  66
 None
 1.06A 2japC-4u4eA:
undetectable		 2japC-4u4eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		5 LEU A  53
SER A 242
ILE A 239
ALA A 387
ALA A 385
 None
 1.27A 2japC-4ug4A:
2.1		 2japC-4ug4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v16 SVP1-LIKE PROTEIN 2

(Kluyveromyces
lactis) 		no annotation 5 LEU A  45
ILE A  17
VAL A 306
ALA A 313
TYR A  40
 None
 1.23A 2japC-4v16A:
undetectable		 2japC-4v16A:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w7h CARBONYL REDUCTASE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		5 LEU A  96
ILE A 151
ALA A 152
ALA A 161
THR A 196
 None
 1.27A 2japC-4w7hA:
30.1		 2japC-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w7h CARBONYL REDUCTASE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		6 SER A 150
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 0.94A 2japC-4w7hA:
30.1		 2japC-4w7hA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w7h CARBONYL REDUCTASE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		5 SER A 150
ILE A 151
ALA A 152
THR A 196
LEU A  96
 None
 1.22A 2japC-4w7hA:
30.1		 2japC-4w7hA:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w91 AMINOTRANSFERASE

(Brucella suis) 		PF00266
(Aminotran_5) 		5 ILE A 241
ALA A 291
VAL A  84
TYR A  77
THR A  99
 None
 0.91A 2japC-4w91A:
3.3		 2japC-4w91A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqz PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 SER A 127
ALA A 129
VAL A 134
TYR A 140
THR A 172
 None
 0.59A 2japC-4yqzA:
16.3		 2japC-4yqzA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 133
SER A 153
ILE A 152
ALA A 121
THR A 148
 None
 1.23A 2japC-4zfhA:
undetectable		 2japC-4zfhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		5 LEU A 535
ILE A 559
VAL A 544
ALA A 547
ARG A 578
 None
 0.95A 2japC-4zu9A:
6.9		 2japC-4zu9A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 SER A 771
ILE A 733
ALA A 735
TYR A 664
ARG A 746
 None
 1.18A 2japC-5a55A:
undetectable		 2japC-5a55A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus) 		PF00266
(Aminotran_5) 		5 ILE A 224
ALA A 274
VAL A  69
TYR A  62
THR A  83
 None
 0.86A 2japC-5b7sA:
undetectable		 2japC-5b7sA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		5 LEU A 395
ILE A 417
ALA A 399
TYR A 239
TYR A 256
 A  B   4 ( 4.6A)
None
None
A  B   3 ( 4.8A)
A  B   4 ( 4.4A)
 1.17A 2japC-5czzA:
2.4		 2japC-5czzA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6s EPOXYQUEUOSINE
REDUCTASE

(Streptococcus
thermophilus) 		PF08331
(DUF1730)
PF13484
(Fer4_16) 		5 LEU A 268
ILE A 298
ALA A 299
THR A 327
LEU A 312
 None
 1.03A 2japC-5d6sA:
undetectable		 2japC-5d6sA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 ILE A 300
ALA A 297
ALA A 278
TYR A 219
LEU A  58
 None
 1.25A 2japC-5e8kA:
undetectable		 2japC-5e8kA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 MET A 390
LEU A 618
ALA A 357
VAL A 433
TYR A 611
 None
 1.05A 2japC-5h53A:
undetectable		 2japC-5h53A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 SER A  85
ILE A  87
VAL A   4
TYR A  35
LEU A  15
 None
None
None
LAQ  A 401 (-4.9A)
None
 1.18A 2japC-5iclA:
undetectable		 2japC-5iclA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ALA A 866
VAL A 870
ALA A 782
THR A 328
LEU A 774
 None
 1.14A 2japC-5iq6A:
undetectable		 2japC-5iq6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Paraburkholderia
xenovorans) 		PF00483
(NTP_transferase) 		5 LEU A 210
ILE A 189
VAL A 244
TYR A 208
LEU A 111
 None
 0.90A 2japC-5j49A:
3.0		 2japC-5j49A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A 575
ALA A 521
VAL A 508
TYR A 577
LEU A 581
 None
 1.18A 2japC-5ja1A:
2.2		 2japC-5ja1A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ALA A 866
VAL A 870
ALA A 782
THR A 328
LEU A 774
 None
 1.17A 2japC-5jjrA:
5.4		 2japC-5jjrA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ALA A 866
VAL A 870
ALA A 782
THR A 329
LEU A 774
 None
 1.13A 2japC-5k5mA:
undetectable		 2japC-5k5mA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A   7
ALA A  32
VAL A  55
ALA A  34
THR A  90
 None
 1.13A 2japC-5ks1A:
9.1		 2japC-5ks1A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0j VINCULIN

(Homo sapiens) 		PF01044
(Vinculin) 		5 MET A 926
ILE A 919
ALA A 957
THR A1037
LEU A 905
 None
 1.26A 2japC-5l0jA:
undetectable		 2japC-5l0jA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 LEU A 400
ILE A 483
VAL A 407
ALA A 403
LEU A 385
 None
 1.02A 2japC-5lq3A:
undetectable		 2japC-5lq3A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkf POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		5 LEU A 415
ILE A 424
VAL A 443
THR A 283
LEU A 409
 None
 1.12A 2japC-5mkfA:
undetectable		 2japC-5mkfA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy1 STRA6

(Danio rerio) 		PF14752
(RBP_receptor) 		5 LEU A 138
ILE A  44
TYR A 135
THR A 159
LEU A 193
 None
 1.02A 2japC-5sy1A:
undetectable		 2japC-5sy1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35

(Homo sapiens) 		no annotation 5 LEU A 774
SER A 587
ALA A 791
TYR A 780
THR A 576
 None
 1.08A 2japC-5txkA:
undetectable		 2japC-5txkA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usx THIOREDOXIN
REDUCTASE

(Vibrio
vulnificus) 		PF07992
(Pyr_redox_2) 		5 LEU A 165
ILE A 241
ALA A 242
ALA A 137
LEU A 174
 None
 1.25A 2japC-5usxA:
5.1		 2japC-5usxA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3

(Mus musculus) 		no annotation 5 LEU A 139
VAL A 249
ALA A 135
TYR A 136
TYR A 163
 None
None
PLP  A 701 (-3.4A)
PLP  A 701 (-4.7A)
None
 1.25A 2japC-5verA:
3.5		 2japC-5verA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 5 LEU A 141
SER A 130
ALA A 140
LEU A 178
TYR A 149
 None
 1.22A 2japC-5wi9A:
3.3		 2japC-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 5 LEU A 191
SER A 163
ILE A 165
LEU A 159
TYR A  10
 None
 1.27A 2japC-5wixA:
undetectable		 2japC-5wixA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Homo sapiens) 		no annotation 5 MET D 130
LEU D 146
ILE A 318
ALA A 317
LEU A 327
 None
 1.08A 2japC-5xnpD:
undetectable		 2japC-5xnpD:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyh CBSA

(Xanthomonas
oryzae) 		no annotation 5 SER A 200
ILE A 202
ALA A 197
ALA A 193
THR A 144
 None
 1.26A 2japC-5xyhA:
2.8		 2japC-5xyhA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-10

(Homo sapiens) 		no annotation 5 LEU B 138
ILE B   3
VAL B 159
ALA B 134
LEU B 122
 None
 1.21A 2japC-6avoB:
undetectable		 2japC-6avoB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 5 ILE A 240
ALA A 157
VAL A 163
ALA A 137
LEU A 258
 None
 1.25A 2japC-6cipA:
2.9		 2japC-6cipA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 5 LEU A 144
SER A 182
ALA A 183
VAL A  28
TYR A 171
 None
 1.19A 2japC-6gneA:
7.2		 2japC-6gneA:
undetectable