SIMILAR PATTERNS OF AMINO ACIDS FOR 2J9D_H_ACTH1113

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrh ECO RI ENDONCULEASE

(Escherichia
coli) 		PF02963
(EcoRI) 		5 GLU A  96
ILE A  94
LYS A  62
GLU A  65
ILE A  61
 None
 1.08A 2j9dG-1qrhA:
0.5
2j9dH-1qrhA:
0.4
2j9dI-1qrhA:
0.0		 2j9dG-1qrhA:
19.84
2j9dH-1qrhA:
19.84
2j9dI-1qrhA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrh ECO RI ENDONCULEASE

(Escherichia
coli) 		PF02963
(EcoRI) 		5 GLU A  96
ILE A  94
LYS A  62
GLU A  65
ILE A  61
 None
 1.10A 2j9dG-1qrhA:
0.5
2j9dH-1qrhA:
0.4
2j9dI-1qrhA:
0.0		 2j9dG-1qrhA:
19.84
2j9dH-1qrhA:
19.84
2j9dI-1qrhA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrh ECO RI ENDONCULEASE

(Escherichia
coli) 		PF02963
(EcoRI) 		5 LYS A  62
GLU A  65
ILE A  61
GLU A  96
ILE A  94
 None
 1.09A 2j9dG-1qrhA:
0.5
2j9dH-1qrhA:
0.4
2j9dI-1qrhA:
0.0		 2j9dG-1qrhA:
19.84
2j9dH-1qrhA:
19.84
2j9dI-1qrhA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyn ARGONAUTE2

(Drosophila
melanogaster) 		PF02170
(PAZ) 		5 LYS A  93
ILE A   8
LYS A  19
GLU A  12
ILE A  20
 None
 1.47A 2j9dG-1vynA:
0.0
2j9dH-1vynA:
undetectable
2j9dI-1vynA:
0.0		 2j9dG-1vynA:
17.76
2j9dH-1vynA:
17.76
2j9dI-1vynA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 GLU A 172
ILE A 141
LYS A 455
GLU A 459
ILE A 456
 None
 0.74A 2j9dG-2ahwA:
0.0
2j9dH-2ahwA:
0.0
2j9dI-2ahwA:
0.0		 2j9dG-2ahwA:
13.94
2j9dH-2ahwA:
13.94
2j9dI-2ahwA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 GLU A 172
ILE A 141
LYS A 455
GLU A 459
ILE A 456
 None
 0.74A 2j9dG-2ahwA:
0.0
2j9dH-2ahwA:
0.0
2j9dI-2ahwA:
0.0		 2j9dG-2ahwA:
13.94
2j9dH-2ahwA:
13.94
2j9dI-2ahwA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 LYS A 455
GLU A 459
ILE A 456
GLU A 172
ILE A 141
 None
 0.71A 2j9dG-2ahwA:
0.0
2j9dH-2ahwA:
0.0
2j9dI-2ahwA:
0.0		 2j9dG-2ahwA:
13.94
2j9dH-2ahwA:
13.94
2j9dI-2ahwA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4x MITOGEN

(Streptococcus
dysgalactiae) 		PF02876
(Stap_Strp_tox_C) 		5 GLU A 191
ILE A 193
ILE A 139
LYS A 177
ILE A 169
 None
 1.22A 2j9dG-2j4xA:
0.0
2j9dH-2j4xA:
0.0
2j9dI-2j4xA:
undetectable		 2j9dG-2j4xA:
19.90
2j9dH-2j4xA:
19.90
2j9dI-2j4xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4x MITOGEN

(Streptococcus
dysgalactiae) 		PF02876
(Stap_Strp_tox_C) 		5 ILE A 139
LYS A 177
ILE A 169
GLU A 191
ILE A 193
 None
 1.25A 2j9dG-2j4xA:
0.0
2j9dH-2j4xA:
0.0
2j9dI-2j4xA:
undetectable		 2j9dG-2j4xA:
19.90
2j9dH-2j4xA:
19.90
2j9dI-2j4xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4x MITOGEN

(Streptococcus
dysgalactiae) 		PF02876
(Stap_Strp_tox_C) 		5 LYS A 177
ILE A 169
GLU A 191
ILE A 193
ILE A 139
 None
 1.23A 2j9dG-2j4xA:
0.0
2j9dH-2j4xA:
0.0
2j9dI-2j4xA:
undetectable		 2j9dG-2j4xA:
19.90
2j9dH-2j4xA:
19.90
2j9dI-2j4xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		5 LYS A 410
GLU A 407
ILE A 406
ILE A 424
ILE A 426
 None
 1.24A 2j9dG-2xdfA:
0.0
2j9dH-2xdfA:
0.0
2j9dI-2xdfA:
0.0		 2j9dG-2xdfA:
12.76
2j9dH-2xdfA:
12.76
2j9dI-2xdfA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 GLU A 237
LYS A 598
GLU A 595
GLU A 398
ILE A 229
 None
 1.27A 2j9dG-2xvgA:
0.0
2j9dH-2xvgA:
0.0
2j9dI-2xvgA:
0.0		 2j9dG-2xvgA:
9.19
2j9dH-2xvgA:
9.19
2j9dI-2xvgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 GLU A 398
ILE A 229
GLU A 237
LYS A 598
GLU A 595
 None
 1.30A 2j9dG-2xvgA:
0.0
2j9dH-2xvgA:
0.0
2j9dI-2xvgA:
0.0		 2j9dG-2xvgA:
9.19
2j9dH-2xvgA:
9.19
2j9dI-2xvgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 LYS A 598
GLU A 595
GLU A 398
ILE A 229
GLU A 237
 None
 1.31A 2j9dG-2xvgA:
0.0
2j9dH-2xvgA:
0.0
2j9dI-2xvgA:
0.0		 2j9dG-2xvgA:
9.19
2j9dH-2xvgA:
9.19
2j9dI-2xvgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 GLU A  10
ILE A  14
GLU A 229
ILE A 228
ILE A 231
 None
 1.08A 2j9dG-3b05A:
0.0
2j9dH-3b05A:
0.0
2j9dI-3b05A:
0.0		 2j9dG-3b05A:
13.51
2j9dH-3b05A:
13.51
2j9dI-3b05A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 GLU A 229
ILE A 228
ILE A 231
GLU A  10
ILE A  14
 None
 1.09A 2j9dG-3b05A:
0.0
2j9dH-3b05A:
0.0
2j9dI-3b05A:
0.0		 2j9dG-3b05A:
13.51
2j9dH-3b05A:
13.51
2j9dI-3b05A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 ILE A 231
GLU A  10
ILE A  14
GLU A 229
ILE A 228
 None
 1.11A 2j9dG-3b05A:
0.0
2j9dH-3b05A:
0.0
2j9dI-3b05A:
0.0		 2j9dG-3b05A:
13.51
2j9dH-3b05A:
13.51
2j9dI-3b05A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		5 GLU A  94
ILE A  90
ILE A  75
LYS A 112
ILE A 100
 None
 1.37A 2j9dG-3kl7A:
0.3
2j9dH-3kl7A:
0.0
2j9dI-3kl7A:
0.2		 2j9dG-3kl7A:
19.47
2j9dH-3kl7A:
19.47
2j9dI-3kl7A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		5 ILE A  75
LYS A 112
ILE A 100
GLU A  94
ILE A  90
 None
 1.36A 2j9dG-3kl7A:
0.3
2j9dH-3kl7A:
0.0
2j9dI-3kl7A:
0.2		 2j9dG-3kl7A:
19.47
2j9dH-3kl7A:
19.47
2j9dI-3kl7A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		5 LYS A 112
ILE A 100
GLU A  94
ILE A  90
ILE A  75
 None
 1.32A 2j9dG-3kl7A:
0.3
2j9dH-3kl7A:
0.0
2j9dI-3kl7A:
0.2		 2j9dG-3kl7A:
19.47
2j9dH-3kl7A:
19.47
2j9dI-3kl7A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLU A 318
ILE A 314
ILE A 104
LYS A  27
ILE A   6
 None
 1.30A 2j9dG-3ouuA:
1.1
2j9dH-3ouuA:
1.4
2j9dI-3ouuA:
1.5		 2j9dG-3ouuA:
15.47
2j9dH-3ouuA:
15.47
2j9dI-3ouuA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LYS A  27
ILE A   6
GLU A 318
ILE A 314
ILE A 104
 None
 1.29A 2j9dG-3ouuA:
1.1
2j9dH-3ouuA:
1.4
2j9dI-3ouuA:
1.5		 2j9dG-3ouuA:
15.47
2j9dH-3ouuA:
15.47
2j9dI-3ouuA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 321
ILE A 319
LYS A 236
GLU A 239
ILE A 240
 None
 1.20A 2j9dG-3q6dA:
1.1
2j9dH-3q6dA:
undetectable
2j9dI-3q6dA:
0.4		 2j9dG-3q6dA:
20.07
2j9dH-3q6dA:
20.07
2j9dI-3q6dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 LYS A 236
GLU A 239
ILE A 240
ILE A 321
ILE A 319
 None
 1.15A 2j9dG-3q6dA:
1.1
2j9dH-3q6dA:
undetectable
2j9dI-3q6dA:
0.4		 2j9dG-3q6dA:
20.07
2j9dH-3q6dA:
20.07
2j9dI-3q6dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		5 ILE A   6
LYS A  39
GLU A  92
ILE A  94
ILE A  35
 MTX  A2001 (-4.0A)
None
None
None
None
 1.43A 2j9dG-3tq9A:
undetectable
2j9dH-3tq9A:
undetectable
2j9dI-3tq9A:
undetectable		 2j9dG-3tq9A:
20.79
2j9dH-3tq9A:
20.79
2j9dI-3tq9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		5 ILE A  35
ILE A   6
LYS A  39
GLU A  92
ILE A  94
 None
MTX  A2001 (-4.0A)
None
None
None
 1.43A 2j9dG-3tq9A:
undetectable
2j9dH-3tq9A:
undetectable
2j9dI-3tq9A:
undetectable		 2j9dG-3tq9A:
20.79
2j9dH-3tq9A:
20.79
2j9dI-3tq9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		5 LYS A  39
GLU A  92
ILE A  94
ILE A  35
ILE A   6
 None
None
None
None
MTX  A2001 (-4.0A)
 1.39A 2j9dG-3tq9A:
undetectable
2j9dH-3tq9A:
undetectable
2j9dI-3tq9A:
undetectable		 2j9dG-3tq9A:
20.79
2j9dH-3tq9A:
20.79
2j9dI-3tq9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		5 GLU A  50
ILE A  49
GLU A  88
GLU A  20
ILE A  79
 None
None
None
None
NDP  A 502 (-3.9A)
 1.25A 2j9dG-4hcxA:
undetectable
2j9dH-4hcxA:
undetectable
2j9dI-4hcxA:
undetectable		 2j9dG-4hcxA:
15.93
2j9dH-4hcxA:
15.93
2j9dI-4hcxA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6s ENDOLYSIN

(Clostridium
phage phiCTP1) 		PF01183
(Glyco_hydro_25) 		5 ILE A  55
LYS A   2
ILE A  25
LYS A 190
ILE A 186
 None
 1.44A 2j9dG-5a6sA:
0.6
2j9dH-5a6sA:
undetectable
2j9dI-5a6sA:
undetectable		 2j9dG-5a6sA:
17.45
2j9dH-5a6sA:
17.45
2j9dI-5a6sA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6s ENDOLYSIN

(Clostridium
phage phiCTP1) 		PF01183
(Glyco_hydro_25) 		5 LYS A   2
ILE A  25
LYS A 190
ILE A 186
ILE A  55
 None
 1.38A 2j9dG-5a6sA:
0.6
2j9dH-5a6sA:
undetectable
2j9dI-5a6sA:
undetectable		 2j9dG-5a6sA:
17.45
2j9dH-5a6sA:
17.45
2j9dI-5a6sA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm5 HYDROXYETHYLTHIAZOLE
KINASE

(Staphylococcus
aureus) 		PF02110
(HK) 		5 GLU A 209
ILE A 212
ILE A 259
GLU A 261
ILE A 173
 None
 0.99A 2j9dG-5cm5A:
undetectable
2j9dH-5cm5A:
undetectable
2j9dI-5cm5A:
0.6		 2j9dG-5cm5A:
18.82
2j9dH-5cm5A:
18.82
2j9dI-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm5 HYDROXYETHYLTHIAZOLE
KINASE

(Staphylococcus
aureus) 		PF02110
(HK) 		5 GLU A 261
ILE A 173
GLU A 209
ILE A 212
ILE A 259
 None
 0.98A 2j9dG-5cm5A:
undetectable
2j9dH-5cm5A:
undetectable
2j9dI-5cm5A:
0.6		 2j9dG-5cm5A:
18.82
2j9dH-5cm5A:
18.82
2j9dI-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm5 HYDROXYETHYLTHIAZOLE
KINASE

(Staphylococcus
aureus) 		PF02110
(HK) 		5 ILE A 259
GLU A 261
ILE A 173
GLU A 209
ILE A 212
 None
 1.00A 2j9dG-5cm5A:
undetectable
2j9dH-5cm5A:
undetectable
2j9dI-5cm5A:
0.6		 2j9dG-5cm5A:
18.82
2j9dH-5cm5A:
18.82
2j9dI-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		5 GLU A 387
LYS A 393
ILE A 396
LYS A 293
GLU A 274
 None
 1.42A 2j9dG-5ivaA:
undetectable
2j9dH-5ivaA:
undetectable
2j9dI-5ivaA:
undetectable		 2j9dG-5ivaA:
10.36
2j9dH-5ivaA:
10.36
2j9dI-5ivaA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		5 LYS A 293
GLU A 274
GLU A 387
LYS A 393
ILE A 396
 None
 1.43A 2j9dG-5ivaA:
undetectable
2j9dH-5ivaA:
undetectable
2j9dI-5ivaA:
undetectable		 2j9dG-5ivaA:
10.36
2j9dH-5ivaA:
10.36
2j9dI-5ivaA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		5 GLU A 319
ILE A 318
ILE A 344
GLU A 411
ILE A 415
 None
 1.17A 2j9dG-5kkgA:
undetectable
2j9dH-5kkgA:
undetectable
2j9dI-5kkgA:
undetectable		 2j9dG-5kkgA:
14.98
2j9dH-5kkgA:
14.98
2j9dI-5kkgA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		5 GLU A 411
ILE A 415
GLU A 319
ILE A 318
ILE A 344
 None
 1.17A 2j9dG-5kkgA:
undetectable
2j9dH-5kkgA:
undetectable
2j9dI-5kkgA:
undetectable		 2j9dG-5kkgA:
14.98
2j9dH-5kkgA:
14.98
2j9dI-5kkgA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 GLU A 631
GLU A 649
ILE A 651
GLU A 662
ILE A 661
 None
 1.23A 2j9dG-5opqA:
0.0
2j9dH-5opqA:
undetectable
2j9dI-5opqA:
undetectable		 2j9dG-5opqA:
undetectable
2j9dH-5opqA:
undetectable
2j9dI-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 GLU A 649
ILE A 651
GLU A 662
ILE A 661
GLU A 631
 None
 1.20A 2j9dG-5opqA:
0.0
2j9dH-5opqA:
undetectable
2j9dI-5opqA:
undetectable		 2j9dG-5opqA:
undetectable
2j9dH-5opqA:
undetectable
2j9dI-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 GLU A 662
ILE A 661
GLU A 631
GLU A 649
ILE A 651
 None
 1.22A 2j9dG-5opqA:
0.0
2j9dH-5opqA:
undetectable
2j9dI-5opqA:
undetectable		 2j9dG-5opqA:
undetectable
2j9dH-5opqA:
undetectable
2j9dI-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 GLU A1153
LYS A1237
GLU A1198
ILE A1239
GLU A1167
 None
 1.39A 2j9dG-5xogA:
4.1
2j9dH-5xogA:
2.3
2j9dI-5xogA:
3.2		 2j9dG-5xogA:
6.28
2j9dH-5xogA:
6.28
2j9dI-5xogA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 GLU A1167
GLU A1153
LYS A1237
GLU A1198
ILE A1239
 None
 1.36A 2j9dG-5xogA:
4.1
2j9dH-5xogA:
2.3
2j9dI-5xogA:
3.2		 2j9dG-5xogA:
6.28
2j9dH-5xogA:
6.28
2j9dI-5xogA:
6.28