SIMILAR PATTERNS OF AMINO ACIDS FOR 2J9D_A_ACTA1117

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e32 P97

(Mus musculus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		3 ASP A  98
ARG A  89
ARG A  95
 None
 0.90A 2j9dA-1e32A:
0.0
2j9dC-1e32A:
0.0		 2j9dA-1e32A:
17.08
2j9dC-1e32A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASP A 231
ARG A 230
ARG A 224
 None
 0.96A 2j9dA-1e5mA:
0.0
2j9dC-1e5mA:
0.0		 2j9dA-1e5mA:
13.79
2j9dC-1e5mA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		3 ASP A  48
ARG A  49
ARG A  10
 None
 1.01A 2j9dA-1ee8A:
0.0
2j9dC-1ee8A:
0.2		 2j9dA-1ee8A:
18.96
2j9dC-1ee8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ASP A 551
ARG A 550
ARG A 554
 None
 1.10A 2j9dA-1eovA:
1.8
2j9dC-1eovA:
1.6		 2j9dA-1eovA:
14.70
2j9dC-1eovA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 ASP A 354
ARG A 355
ARG A 358
 None
 1.02A 2j9dA-1kq3A:
0.0
2j9dC-1kq3A:
0.0		 2j9dA-1kq3A:
16.33
2j9dC-1kq3A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09105
(SelB-wing_1)
PF09106
(SelB-wing_2)
PF09107
(SelB-wing_3) 		3 ASP A 617
ARG A 623
ARG A 624
 None
 1.10A 2j9dA-1lvaA:
0.0
2j9dC-1lvaA:
0.1		 2j9dA-1lvaA:
18.99
2j9dC-1lvaA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4x PBCV-1 VIRUS CAPSID

(Paramecium
bursaria
Chlorella virus
1) 		PF04451
(Capsid_NCLDV)
PF16903
(Capsid_N) 		3 ASP A 125
ARG A 126
ARG A 121
 None
 0.56A 2j9dA-1m4xA:
0.0
2j9dC-1m4xA:
0.1		 2j9dA-1m4xA:
13.70
2j9dC-1m4xA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh8 HYPOTHETICAL PROTEIN
PA5026

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		3 ASP A  94
ARG A  96
ARG A  37
 None
 0.65A 2j9dA-1sh8A:
0.0
2j9dC-1sh8A:
0.0		 2j9dA-1sh8A:
23.23
2j9dC-1sh8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASP A  40
ARG A 395
ARG A  36
 None
 0.94A 2j9dA-1uliA:
undetectable
2j9dC-1uliA:
0.0		 2j9dA-1uliA:
13.14
2j9dC-1uliA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5p PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING,
FAMILY A

(Mus musculus) 		PF00169
(PH) 		3 ASP A  22
ARG A  35
ARG A  34
 None
 0.92A 2j9dA-1v5pA:
undetectable
2j9dC-1v5pA:
undetectable		 2j9dA-1v5pA:
20.44
2j9dC-1v5pA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdi HYPOTHETICAL PROTEIN
TT0907

(Thermus
thermophilus) 		PF02547
(Queuosine_synth) 		3 ASP A  25
ARG A  44
ARG A  46
 None
 0.75A 2j9dA-1wdiA:
undetectable
2j9dC-1wdiA:
undetectable		 2j9dA-1wdiA:
17.47
2j9dC-1wdiA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASP A  43
ARG A 405
ARG A  39
 None
 0.94A 2j9dA-1wqlA:
undetectable
2j9dC-1wqlA:
undetectable		 2j9dA-1wqlA:
15.02
2j9dC-1wqlA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5f NEOGENIN

(Homo sapiens) 		PF00041
(fn3) 		3 ASP A  23
ARG A  22
ARG A  39
 None
 1.05A 2j9dA-1x5fA:
undetectable
2j9dC-1x5fA:
undetectable		 2j9dA-1x5fA:
19.55
2j9dC-1x5fA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens) 		PF08609
(Fes1) 		3 ASP A 197
ARG A 194
ARG A 198
 None
 1.00A 2j9dA-1xqsA:
undetectable
2j9dC-1xqsA:
undetectable		 2j9dA-1xqsA:
20.24
2j9dC-1xqsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuo HYPOTHETICAL PROTEIN
LOC92912

(Homo sapiens) 		PF00179
(UQ_con) 		3 ASP A 215
ARG A 218
ARG A 214
 None
 1.07A 2j9dA-1zuoA:
undetectable
2j9dC-1zuoA:
undetectable		 2j9dA-1zuoA:
18.82
2j9dC-1zuoA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab3 ZNF29

(Escherichia
coli) 		PF00096
(zf-C2H2) 		3 ASP A  16
ARG A  22
ARG A  18
 None
 1.05A 2j9dA-2ab3A:
undetectable
2j9dC-2ab3A:
undetectable		 2j9dA-2ab3A:
10.26
2j9dC-2ab3A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		3 ASP H 289
ARG H 288
ARG H 265
 None
 1.03A 2j9dA-2bbkH:
undetectable
2j9dC-2bbkH:
undetectable		 2j9dA-2bbkH:
16.43
2j9dC-2bbkH:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		3 ASP H 289
ARG H 288
ARG H 292
 None
 1.10A 2j9dA-2bbkH:
undetectable
2j9dC-2bbkH:
undetectable		 2j9dA-2bbkH:
16.43
2j9dC-2bbkH:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 ASP A 132
ARG A 175
ARG A 131
 None
 1.04A 2j9dA-2bccA:
3.5
2j9dC-2bccA:
2.5		 2j9dA-2bccA:
14.50
2j9dC-2bccA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3v THERMONUCLEASE

(Staphylococcus
aureus) 		PF00565
(SNase) 		3 ASP A  21
ARG A  87
ARG A  35
 None
 0.99A 2j9dA-2f3vA:
undetectable
2j9dC-2f3vA:
undetectable		 2j9dA-2f3vA:
26.81
2j9dC-2f3vA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj3 MAJOR PRION PROTEIN

(Oryctolagus
cuniculus) 		PF00377
(Prion) 		3 ASP A 146
ARG A 147
ARG A 150
 None
 0.95A 2j9dA-2fj3A:
undetectable
2j9dC-2fj3A:
undetectable		 2j9dA-2fj3A:
19.42
2j9dC-2fj3A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASP A 274
ARG A 273
ARG A 267
 None
 0.89A 2j9dA-2ix4A:
undetectable
2j9dC-2ix4A:
undetectable		 2j9dA-2ix4A:
15.02
2j9dC-2ix4A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krh ACTIN-BINDING
RHO-ACTIVATING
PROTEIN

(Rattus
norvegicus) 		PF14705
(Costars) 		3 ASP A  30
ARG A  28
ARG A  29
 None
 1.05A 2j9dA-2krhA:
undetectable
2j9dC-2krhA:
undetectable		 2j9dA-2krhA:
23.81
2j9dC-2krhA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kuo APRATAXIN AND
PNK-LIKE FACTOR

(Homo sapiens) 		PF10283
(zf-CCHH) 		3 ASP A 417
ARG A 439
ARG A 418
 None
 1.00A 2j9dA-2kuoA:
undetectable
2j9dC-2kuoA:
undetectable		 2j9dA-2kuoA:
18.49
2j9dC-2kuoA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5g PUTATIVE
UNCHARACTERIZED
PROTEIN NCOR2

(Homo sapiens) 		PF15784
(GPS2_interact) 		3 ASP B 177
ARG B 178
ARG B 181
 None
 1.08A 2j9dA-2l5gB:
undetectable
2j9dC-2l5gB:
undetectable		 2j9dA-2l5gB:
13.45
2j9dC-2l5gB:
13.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ma3 DNA REPLICATION
INITIATOR
(CDC21/CDC54)

(Methanothermobacter
thermautotrophicus) 		no annotation 3 ASP A 602
ARG A 601
ARG A 605
 None
 1.01A 2j9dA-2ma3A:
undetectable
2j9dC-2ma3A:
undetectable		 2j9dA-2ma3A:
31.13
2j9dC-2ma3A:
31.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhc TNPX

(Clostridium
perfringens) 		PF00239
(Resolvase) 		3 ASP A  51
ARG A  61
ARG A  13
 None
 0.57A 2j9dA-2mhcA:
undetectable
2j9dC-2mhcA:
undetectable		 2j9dA-2mhcA:
21.05
2j9dC-2mhcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n6r U4-HEXATOXIN-HI1A

(Hadronyche
infensa) 		PF17486
(Cys_Knot_tox) 		3 ASP A  60
ARG A  61
ARG A  27
 None
 0.99A 2j9dA-2n6rA:
undetectable
2j9dC-2n6rA:
undetectable		 2j9dA-2n6rA:
18.18
2j9dC-2n6rA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7a SIALIC ACID-BINDING
IG-LIKE LECTIN 8

(Homo sapiens) 		PF07686
(V-set) 		3 ASP A 102
ARG A 101
ARG A  99
 None
 1.05A 2j9dA-2n7aA:
undetectable
2j9dC-2n7aA:
undetectable		 2j9dA-2n7aA:
21.13
2j9dC-2n7aA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 280
ARG A 277
ARG A 276
 None
 0.95A 2j9dA-2rdxA:
undetectable
2j9dC-2rdxA:
undetectable		 2j9dA-2rdxA:
13.77
2j9dC-2rdxA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		3 ASP A 271
ARG A 275
ARG A 272
 None
 1.10A 2j9dA-2v8jA:
undetectable
2j9dC-2v8jA:
undetectable		 2j9dA-2v8jA:
13.64
2j9dC-2v8jA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis) 		PF00225
(Kinesin) 		3 ASP A 289
ARG A 294
ARG A 288
 None
 1.00A 2j9dA-2vvgA:
undetectable
2j9dC-2vvgA:
undetectable		 2j9dA-2vvgA:
20.91
2j9dC-2vvgA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ASP A 803
ARG A 784
ARG A 806
 None
 0.90A 2j9dA-2wanA:
undetectable
2j9dC-2wanA:
undetectable		 2j9dA-2wanA:
8.58
2j9dC-2wanA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wg3 DESERT HEDGEHOG
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01085
(HH_signal) 		3 ASP A 189
ARG A 145
ARG A 102
 None
 1.06A 2j9dA-2wg3A:
2.7
2j9dC-2wg3A:
2.3		 2j9dA-2wg3A:
22.36
2j9dC-2wg3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2s RPOE, ECF SIGE

(Rhodobacter
sphaeroides) 		PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		3 ASP A  95
ARG A  93
ARG A  88
 None
 1.05A 2j9dA-2z2sA:
undetectable
2j9dC-2z2sA:
undetectable		 2j9dA-2z2sA:
23.91
2j9dC-2z2sA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 ASP A 272
ARG A 276
ARG A 275
 None
 1.04A 2j9dA-2zufA:
undetectable
2j9dC-2zufA:
undetectable		 2j9dA-2zufA:
11.43
2j9dC-2zufA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3u MENAQUINONE
BIOSYNTHETIC ENZYME

(Thermus
thermophilus) 		PF02621
(VitK2_biosynth) 		3 ASP A  66
ARG A  67
ARG A 183
 None
 1.03A 2j9dA-3a3uA:
undetectable
2j9dC-3a3uA:
undetectable		 2j9dA-3a3uA:
20.00
2j9dC-3a3uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE

(Sphingomonas
paucimobilis) 		PF13577
(SnoaL_4) 		3 ASP A   3
ARG A  10
ARG A   6
 None
 0.86A 2j9dA-3a76A:
undetectable
2j9dC-3a76A:
undetectable		 2j9dA-3a76A:
20.81
2j9dC-3a76A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A 150
ARG A 149
ARG A 189
 None
 1.08A 2j9dA-3coiA:
undetectable
2j9dC-3coiA:
undetectable		 2j9dA-3coiA:
18.65
2j9dC-3coiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASP A  38
ARG A 393
ARG A  34
 None
 1.00A 2j9dA-3eqqA:
undetectable
2j9dC-3eqqA:
undetectable		 2j9dA-3eqqA:
13.33
2j9dC-3eqqA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gag PUTATIVE NADH
DEHYDROGENASE, NADPH
NITROREDUCTASE

(Streptococcus
mutans) 		PF00881
(Nitroreductase) 		3 ASP A 152
ARG A  12
ARG A 147
 GOL  A 208 (-3.4A)
FMN  A 500 (-2.7A)
None
 0.71A 2j9dA-3gagA:
2.2
2j9dC-3gagA:
2.1		 2j9dA-3gagA:
20.00
2j9dC-3gagA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 3 ASP A 202
ARG A 146
ARG A 175
 None
 1.09A 2j9dA-3gozA:
undetectable
2j9dC-3gozA:
undetectable		 2j9dA-3gozA:
15.43
2j9dC-3gozA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASP A 191
ARG A 192
ARG A 587
 None
 1.06A 2j9dA-3ixwA:
undetectable
2j9dC-3ixwA:
undetectable		 2j9dA-3ixwA:
11.80
2j9dC-3ixwA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE

(Klebsiella
pneumoniae) 		PF00571
(CBS) 		3 ASP A 276
ARG A 232
ARG A 275
 None
 1.06A 2j9dA-3k2vA:
undetectable
2j9dC-3k2vA:
undetectable		 2j9dA-3k2vA:
23.53
2j9dC-3k2vA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A  51
ARG A 410
ARG A  50
 None
 1.07A 2j9dA-3krtA:
undetectable
2j9dC-3krtA:
undetectable		 2j9dA-3krtA:
14.53
2j9dC-3krtA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5

(Homo sapiens) 		PF01094
(ANF_receptor) 		3 ASP A  97
ARG A  96
ARG A  26
 None
 1.08A 2j9dA-3lmkA:
undetectable
2j9dC-3lmkA:
undetectable		 2j9dA-3lmkA:
12.20
2j9dC-3lmkA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		3 ASP A 377
ARG A 400
ARG A 378
 None
 1.11A 2j9dA-3lx6A:
undetectable
2j9dC-3lx6A:
undetectable		 2j9dA-3lx6A:
14.63
2j9dC-3lx6A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		3 ASP A 377
ARG A 400
ARG A 378
 None
 1.04A 2j9dA-3me5A:
undetectable
2j9dC-3me5A:
undetectable		 2j9dA-3me5A:
13.07
2j9dC-3me5A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASP A 228
ARG A 227
ARG A 221
 None
 0.89A 2j9dA-3oytA:
undetectable
2j9dC-3oytA:
undetectable		 2j9dA-3oytA:
17.60
2j9dC-3oytA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE

(Campylobacter
jejuni) 		PF00162
(PGK) 		3 ASP A  35
ARG A  38
ARG A  37
 None
 1.09A 2j9dA-3q3vA:
undetectable
2j9dC-3q3vA:
undetectable		 2j9dA-3q3vA:
16.17
2j9dC-3q3vA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		3 ASP B 906
ARG B 907
ARG B 901
 None
 1.10A 2j9dA-3qd2B:
2.7
2j9dC-3qd2B:
undetectable		 2j9dA-3qd2B:
19.02
2j9dC-3qd2B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmh CPG-BINDING PROTEIN

(Homo sapiens) 		PF02008
(zf-CXXC) 		3 ASP A 180
ARG A 177
ARG A 206
 None
 1.00A 2j9dA-3qmhA:
undetectable
2j9dC-3qmhA:
undetectable		 2j9dA-3qmhA:
17.54
2j9dC-3qmhA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rtx MRNA-CAPPING ENZYME

(Mus musculus) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		3 ASP A 314
ARG A 299
ARG A 315
 None
GUN  A   1 (-3.8A)
None
 0.96A 2j9dA-3rtxA:
undetectable
2j9dC-3rtxA:
undetectable		 2j9dA-3rtxA:
15.82
2j9dC-3rtxA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 3 ASP A 192
ARG A 194
ARG A 191
 None
 0.79A 2j9dA-3ssmA:
undetectable
2j9dC-3ssmA:
undetectable		 2j9dA-3ssmA:
15.22
2j9dC-3ssmA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		3 ASP A 474
ARG A 478
ARG A 249
 None
 0.93A 2j9dA-3t5tA:
undetectable
2j9dC-3t5tA:
undetectable		 2j9dA-3t5tA:
12.63
2j9dC-3t5tA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 ASP A 100
ARG A  98
ARG A 106
 None
 0.59A 2j9dA-3ttsA:
undetectable
2j9dC-3ttsA:
undetectable		 2j9dA-3ttsA:
11.60
2j9dC-3ttsA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASP A 225
ARG A 224
ARG A 218
 None
 1.00A 2j9dA-3u0fA:
undetectable
2j9dC-3u0fA:
undetectable		 2j9dA-3u0fA:
16.53
2j9dC-3u0fA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vac CFA/I FIMBRIAL
SUBUNIT E

(Escherichia
coli) 		PF07434
(CblD) 		3 ASP A 184
ARG A 182
ARG A  67
 None
 1.08A 2j9dA-3vacA:
undetectable
2j9dC-3vacA:
undetectable		 2j9dA-3vacA:
12.96
2j9dC-3vacA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtw OPTINEURIN,
MICROTUBULE-ASSOCIAT
ED PROTEINS 1A/1B
LIGHT CHAIN 3B

(Homo sapiens) 		PF02991
(Atg8) 		3 ASP A  34
ARG A  31
ARG A  26
 None
SO4  A 201 (-2.5A)
None
 0.96A 2j9dA-3vtwA:
undetectable
2j9dC-3vtwA:
undetectable		 2j9dA-3vtwA:
24.84
2j9dC-3vtwA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		3 ASP A  67
ARG A  68
ARG A  63
 None
 1.02A 2j9dA-3wwxA:
undetectable
2j9dC-3wwxA:
undetectable		 2j9dA-3wwxA:
15.69
2j9dC-3wwxA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		3 ASP A 158
ARG A 159
ARG A 304
 None
 1.11A 2j9dA-4aa9A:
undetectable
2j9dC-4aa9A:
undetectable		 2j9dA-4aa9A:
15.48
2j9dC-4aa9A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b62 TSSL1

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		3 ASP A 325
ARG A 305
ARG A 307
 None
 0.72A 2j9dA-4b62A:
undetectable
2j9dC-4b62A:
1.9		 2j9dA-4b62A:
24.84
2j9dC-4b62A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ASP A 553
ARG A 554
ARG A 550
 None
 1.01A 2j9dA-4bziA:
undetectable
2j9dC-4bziA:
undetectable		 2j9dA-4bziA:
8.82
2j9dC-4bziA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		3 ASP A 560
ARG A 559
ARG B 447
 None
 0.98A 2j9dA-4cakA:
undetectable
2j9dC-4cakA:
undetectable		 2j9dA-4cakA:
8.57
2j9dC-4cakA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASP A 237
ARG A 236
ARG A 230
 None
 0.93A 2j9dA-4f32A:
undetectable
2j9dC-4f32A:
undetectable		 2j9dA-4f32A:
14.58
2j9dC-4f32A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ASP A 329
ARG A 336
ARG A 335
 None
 0.87A 2j9dA-4hozA:
undetectable
2j9dC-4hozA:
undetectable		 2j9dA-4hozA:
12.93
2j9dC-4hozA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ibo GLUCONATE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		3 ASP A  44
ARG A  21
ARG A  47
 None
 1.10A 2j9dA-4iboA:
undetectable
2j9dC-4iboA:
undetectable		 2j9dA-4iboA:
20.31
2j9dC-4iboA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ASP A 323
ARG A 344
ARG A 342
 None
 0.93A 2j9dA-4j0xA:
undetectable
2j9dC-4j0xA:
undetectable		 2j9dA-4j0xA:
14.86
2j9dC-4j0xA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1v MOB KINASE ACTIVATOR
1A

(Homo sapiens) 		PF03637
(Mob1_phocein) 		3 ASP A 197
ARG A 198
ARG A 199
 None
 0.95A 2j9dA-4j1vA:
undetectable
2j9dC-4j1vA:
undetectable		 2j9dA-4j1vA:
18.38
2j9dC-4j1vA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		3 ASP A 335
ARG A 334
ARG A 331
 None
 1.05A 2j9dA-4k37A:
undetectable
2j9dC-4k37A:
undetectable		 2j9dA-4k37A:
15.95
2j9dC-4k37A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k68 GH10 XYLANASE

(soil metagenome) 		PF00331
(Glyco_hydro_10) 		3 ASP A 299
ARG A 298
ARG A 354
 None
 1.10A 2j9dA-4k68A:
undetectable
2j9dC-4k68A:
undetectable		 2j9dA-4k68A:
16.36
2j9dC-4k68A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN

(Ralstonia
solanacearum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 ASP A 278
ARG A  54
ARG A  53
 None
GSH  A 405 (-3.9A)
GSH  A 405 (-3.5A)
 0.67A 2j9dA-4kf9A:
undetectable
2j9dC-4kf9A:
undetectable		 2j9dA-4kf9A:
13.73
2j9dC-4kf9A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kny KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 ASP A 206
ARG A 211
ARG A 209
 None
 1.09A 2j9dA-4knyA:
undetectable
2j9dC-4knyA:
undetectable		 2j9dA-4knyA:
23.96
2j9dC-4knyA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt6 POLY(A) POLYMERASE
GAMMA

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		3 ASP A 193
ARG A 171
ARG A 125
 None
 1.01A 2j9dA-4lt6A:
5.0
2j9dC-4lt6A:
4.4		 2j9dA-4lt6A:
14.00
2j9dC-4lt6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 3 ASP B 364
ARG B 365
ARG B 368
 None
 0.99A 2j9dA-4pl2B:
undetectable
2j9dC-4pl2B:
undetectable		 2j9dA-4pl2B:
17.89
2j9dC-4pl2B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		3 ASP A  93
ARG A  72
ARG A  94
 None
GPL  A  67 (-4.6A)
None
 1.06A 2j9dA-4pz7A:
undetectable
2j9dC-4pz7A:
undetectable		 2j9dA-4pz7A:
14.07
2j9dC-4pz7A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASP A 229
ARG A 228
ARG A 222
 None
None
FMT  A 502 (-3.1A)
 0.91A 2j9dA-4qavA:
undetectable
2j9dC-4qavA:
undetectable		 2j9dA-4qavA:
13.83
2j9dC-4qavA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASP A 227
ARG A 226
ARG A 220
 None
 1.00A 2j9dA-4r8eA:
undetectable
2j9dC-4r8eA:
undetectable		 2j9dA-4r8eA:
14.29
2j9dC-4r8eA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		3 ASP A  22
ARG A  27
ARG A  26
 None
 1.09A 2j9dA-4tpnA:
undetectable
2j9dC-4tpnA:
undetectable		 2j9dA-4tpnA:
13.78
2j9dC-4tpnA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		3 ASP A 250
ARG A 244
ARG A 245
 None
 1.10A 2j9dA-4us5A:
undetectable
2j9dC-4us5A:
undetectable		 2j9dA-4us5A:
16.18
2j9dC-4us5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		3 ASP A 187
ARG A  24
ARG A  22
 None
ACT  A 408 (-3.1A)
None
 0.80A 2j9dA-4xdtA:
2.8
2j9dC-4xdtA:
1.0		 2j9dA-4xdtA:
16.42
2j9dC-4xdtA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASP A 225
ARG A 224
ARG A 218
 None
 0.89A 2j9dA-4xoxA:
undetectable
2j9dC-4xoxA:
undetectable		 2j9dA-4xoxA:
17.19
2j9dC-4xoxA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		3 ASP A  98
ARG A  89
ARG A  95
 None
 1.01A 2j9dA-5c1bA:
undetectable
2j9dC-5c1bA:
undetectable		 2j9dA-5c1bA:
10.36
2j9dC-5c1bA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		3 ASP A 215
ARG A  93
ARG A 217
 None
 1.02A 2j9dA-5cweA:
undetectable
2j9dC-5cweA:
undetectable		 2j9dA-5cweA:
13.99
2j9dC-5cweA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		3 ASP A 212
ARG A 343
ARG A 208
 None
 1.00A 2j9dA-5du9A:
3.2
2j9dC-5du9A:
2.7		 2j9dA-5du9A:
12.44
2j9dC-5du9A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqd UDP-GALACTOPYRANOSE
MUTASE

(Mycolicibacterium
smegmatis) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		3 ASP A 239
ARG A 242
ARG A 238
 None
 0.86A 2j9dA-5eqdA:
undetectable
2j9dC-5eqdA:
undetectable		 2j9dA-5eqdA:
16.58
2j9dC-5eqdA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0b MYELOID CELL SURFACE
ANTIGEN CD33

(Homo sapiens) 		PF00047
(ig)
PF07686
(V-set) 		3 ASP A 112
ARG A 111
ARG A 109
 None
 0.99A 2j9dA-5j0bA:
undetectable
2j9dC-5j0bA:
undetectable		 2j9dA-5j0bA:
18.02
2j9dC-5j0bA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja4 DNA REPLICATION
LICENSING FACTOR
MCM2

(Homo sapiens) 		PF12619
(MCM2_N) 		3 ASP C  80
ARG C  82
ARG C  79
 None
 1.05A 2j9dA-5ja4C:
undetectable
2j9dC-5ja4C:
undetectable		 2j9dA-5ja4C:
22.22
2j9dC-5ja4C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm0 L-2

(Triticum
kiharae) 		PF14861
(Antimicrobial21) 		3 ASP A   3
ARG A   4
ARG A   7
 None
 1.09A 2j9dA-5lm0A:
undetectable
2j9dC-5lm0A:
undetectable		 2j9dA-5lm0A:
10.91
2j9dC-5lm0A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		3 ASP B 442
ARG B 448
ARG B 444
 None
 0.71A 2j9dA-5m5xB:
undetectable
2j9dC-5m5xB:
undetectable		 2j9dA-5m5xB:
7.90
2j9dC-5m5xB:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L18,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00861
(Ribosomal_L18p) 		3 ASP Q 142
ARG Q  70
ARG Q  72
 None
A  A2395 ( 2.8A)
G  B  10 ( 3.5A)
 1.07A 2j9dA-5mlcQ:
undetectable
2j9dC-5mlcQ:
undetectable		 2j9dA-5mlcQ:
20.22
2j9dC-5mlcQ:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpg HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1

(Homo sapiens) 		PF00076
(RRM_1) 		3 ASP A  48
ARG A  47
ARG A  55
 None
G  B   5 ( 4.0A)
G  B   4 ( 3.6A)
 0.87A 2j9dA-5mpgA:
2.9
2j9dC-5mpgA:
2.5		 2j9dA-5mpgA:
25.20
2j9dC-5mpgA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		3 ASP A 139
ARG A 144
ARG A 142
 None
 0.88A 2j9dA-5nagA:
undetectable
2j9dC-5nagA:
undetectable		 2j9dA-5nagA:
11.98
2j9dC-5nagA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		3 ASP J 364
ARG J 357
ARG J 359
 None
 0.91A 2j9dA-5nilJ:
3.1
2j9dC-5nilJ:
2.9		 2j9dA-5nilJ:
11.67
2j9dC-5nilJ:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uh7 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		no annotation 3 ASP A 108
ARG A  64
ARG A 107
 None
 1.00A 2j9dA-5uh7A:
undetectable
2j9dC-5uh7A:
undetectable		 2j9dA-5uh7A:
21.05
2j9dC-5uh7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwy THIOREDOXIN
REDUCTASE

(Streptococcus
pyogenes) 		PF07992
(Pyr_redox_2) 		3 ASP A 196
ARG A 171
ARG A 172
 None
 0.86A 2j9dA-5uwyA:
undetectable
2j9dC-5uwyA:
undetectable		 2j9dA-5uwyA:
21.00
2j9dC-5uwyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 3 ASP A 137
ARG A 176
ARG A 138
 None
 1.06A 2j9dA-5wgcA:
undetectable
2j9dC-5wgcA:
undetectable		 2j9dA-5wgcA:
undetectable
2j9dC-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 3 ASP A 218
ARG A 236
ARG A 223
 MG  A 402 ( 3.8A)
None
None
 1.10A 2j9dA-6b07A:
undetectable
2j9dC-6b07A:
undetectable		 2j9dA-6b07A:
undetectable
2j9dC-6b07A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bld CYTOCHROME P450
268A2 CYP268A2

(Mycobacterium
marinum) 		no annotation 3 ASP A 344
ARG A  37
ARG A  66
 None
 1.09A 2j9dA-6bldA:
undetectable
2j9dC-6bldA:
undetectable		 2j9dA-6bldA:
undetectable
2j9dC-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2s TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Rhodopseudomonas
palustris) 		no annotation 3 ASP A 167
ARG A 169
ARG A 166
 None
 1.09A 2j9dA-6c2sA:
undetectable
2j9dC-6c2sA:
undetectable		 2j9dA-6c2sA:
undetectable
2j9dC-6c2sA:
undetectable