SIMILAR PATTERNS OF AMINO ACIDS FOR 2J7X_A_ESTA1454_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		5 MET A 301
MET A 304
LEU A 308
ILE A 381
LEU A 345
 None
 1.23A 2j7xA-1dl2A:
0.0		 2j7xA-1dl2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 LEU A 116
LEU A 115
ILE A  83
GLY A 121
LEU A 123
 None
 0.92A 2j7xA-1gynA:
undetectable		 2j7xA-1gynA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 132
LEU A 133
ILE A  63
GLY A 113
LEU A 114
 None
 1.29A 2j7xA-1h4lA:
0.7		 2j7xA-1h4lA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		5 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.23A 2j7xA-1hfeL:
0.0		 2j7xA-1hfeL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 LEU A 264
MET A 234
ILE A 206
GLY A 231
HIS A 203
 None
 0.99A 2j7xA-1hplA:
undetectable		 2j7xA-1hplA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		5 LEU A 601
GLU A 518
ARG A 522
GLY A 623
HIS A 192
 None
 1.28A 2j7xA-1kehA:
0.0		 2j7xA-1kehA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa) 		PF05184
(SapB_1) 		5 MET A  49
GLU A  24
LEU A  61
ILE A  69
LEU A  14
 None
 1.03A 2j7xA-1nklA:
0.6		 2j7xA-1nklA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 LEU A 143
LEU A  78
ILE A 104
GLY A  72
LEU A  69
 None
 0.96A 2j7xA-1p2xA:
0.0		 2j7xA-1p2xA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 LEU A 143
LEU A  78
ILE A 104
GLY A  72
LEU A  69
 HG  A 191 ( 4.8A)
None
None
None
None
 0.99A 2j7xA-1p5sA:
0.0		 2j7xA-1p5sA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 342
LEU A 349
GLU A 353
LEU A 391
ARG A 394
 None
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
 1.23A 2j7xA-1pcgA:
33.5		 2j7xA-1pcgA:
59.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 MET A 343
LEU A 349
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
ILE A 424
GLY A 521
HIS A 524
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 0.35A 2j7xA-1pcgA:
33.5		 2j7xA-1pcgA:
59.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5p NAD-DEPENDENT
DEACETYLASE

(Escherichia
coli) 		PF02146
(SIR2) 		5 GLU A 136
LEU A 126
ILE A 200
GLY A 196
LEU A 195
 None
 1.15A 2j7xA-1s5pA:
undetectable		 2j7xA-1s5pA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		5 MET A 178
LEU A 208
LEU A 207
GLY A 213
LEU A 215
 None
 1.27A 2j7xA-1t98A:
undetectable		 2j7xA-1t98A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 LEU A  75
GLU A  78
ARG A  88
GLY A 242
LEU A 248
 MPD  A3003 (-4.7A)
None
None
None
None
 1.29A 2j7xA-1wz8A:
undetectable		 2j7xA-1wz8A:
24.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 327
GLU A 331
MET A 362
LEU A 365
ARG A 372
HIS A 494
 None
 0.55A 2j7xA-1xb7A:
28.2		 2j7xA-1xb7A:
34.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybf AMP NUCLEOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01048
(PNP_UDP_1) 		5 LEU A 207
LEU A 206
ILE A  92
GLY A 239
LEU A 236
 None
 1.07A 2j7xA-1ybfA:
undetectable		 2j7xA-1ybfA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		5 LEU A 132
MET A   4
LEU A  63
GLY A 144
LEU A 291
 None
 1.28A 2j7xA-1yleA:
undetectable		 2j7xA-1yleA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys5 LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 LEU A 114
LEU A  94
ILE A 150
GLY A  64
LEU A  90
 None
 1.30A 2j7xA-1ys5A:
undetectable		 2j7xA-1ys5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 LEU I 224
ILE I 412
GLY I 231
HIS I 232
LEU I 233
 None
 1.25A 2j7xA-1yveI:
undetectable		 2j7xA-1yveI:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		5 LEU C 432
GLU C 349
ARG C 353
GLY C 454
HIS B  23
 None
 1.24A 2j7xA-2advC:
undetectable		 2j7xA-2advC:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9q GRANULOCYTE
COLONY-STIMULATING
FACTOR RECEPTOR

(Homo sapiens) 		PF06328
(Lep_receptor_Ig) 		5 LEU B 171
LEU B 170
ARG B 167
ILE B 178
GLY B 177
 None
 1.23A 2j7xA-2d9qB:
undetectable		 2j7xA-2d9qB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		5 LEU A 269
MET A 178
ILE A 155
GLY A 173
LEU A 159
 None
 1.25A 2j7xA-2dpyA:
undetectable		 2j7xA-2dpyA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		5 LEU A  66
LEU A  60
GLY A  25
HIS A  22
LEU A  23
 None
 1.10A 2j7xA-2eg3A:
undetectable		 2j7xA-2eg3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2f CYTOLETHAL
DISTENDING TOXIN C

(Aggregatibacter
actinomycetemcomitans) 		PF03498
(CDtoxinA) 		5 LEU C 132
LEU C  79
ILE C 118
GLY C  83
LEU C  85
 None
 1.30A 2j7xA-2f2fC:
undetectable		 2j7xA-2f2fC:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		5 LEU A  93
LEU A 129
MET A 128
ILE A 110
GLY A 107
 None
 1.28A 2j7xA-2g8lA:
undetectable		 2j7xA-2g8lA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 271
GLU A 275
MET A 306
LEU A 309
ARG A 316
HIS A 434
 OHT  A 500 ( 4.4A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.48A 2j7xA-2gpvA:
26.8		 2j7xA-2gpvA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120) 		PF00378
(ECH_1) 		5 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 1.02A 2j7xA-2j5gD:
undetectable		 2j7xA-2j5gD:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lop TRANSMEMBRANE
PROTEIN 14A

(Homo sapiens) 		PF03647
(Tmemb_14) 		5 MET A  89
LEU A  92
LEU A  96
GLY A  36
LEU A  33
 None
 1.09A 2j7xA-2lopA:
undetectable		 2j7xA-2lopA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsj DNA REPAIR PROTEIN
REV1

(Mus musculus) 		PF16727
(REV1_C) 		5 LEU A  65
MET A  81
LEU A  27
ILE A  55
LEU A 101
 None
 1.24A 2j7xA-2lsjA:
undetectable		 2j7xA-2lsjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mr7 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00550
(PP-binding) 		5 LEU A  15
LEU A  47
GLY A  39
HIS A  35
LEU A  37
 None
 1.24A 2j7xA-2mr7A:
undetectable		 2j7xA-2mr7A:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 342
LEU A 349
GLU A 353
LEU A 391
ARG A 394
 None
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
 1.25A 2j7xA-2ocfA:
34.0		 2j7xA-2ocfA:
53.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 MET A 343
LEU A 349
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
ILE A 424
GLY A 521
HIS A 524
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
 0.42A 2j7xA-2ocfA:
34.0		 2j7xA-2ocfA:
53.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 343
LEU A 402
ILE A 424
GLY A 521
HIS A 524
 EST  A 596 (-4.8A)
None
EST  A 596 ( 4.7A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
 1.20A 2j7xA-2ocfA:
34.0		 2j7xA-2ocfA:
53.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 139
LEU A 140
ILE A  65
GLY A 120
LEU A 121
 None
 1.15A 2j7xA-2pmiA:
undetectable		 2j7xA-2pmiA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r32 GCN4-PII/TUMOR
NECROSIS FACTOR
LIGAND SUPERFAMILY
MEMBER 18 FUSION
PROTEIN

(Homo sapiens;
Saccharomyces
cerevisiae) 		no annotation 5 LEU A 170
ILE A 176
GLY A  93
HIS A 143
LEU A 142
 None
 1.26A 2j7xA-2r32A:
undetectable		 2j7xA-2r32A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xnf MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 25

(Homo sapiens) 		PF11232
(Med25) 		5 LEU A 511
LEU A 525
LEU A 514
GLY A 462
LEU A 464
 None
 1.27A 2j7xA-2xnfA:
undetectable		 2j7xA-2xnfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 GLU A 373
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.07A 2j7xA-2zkjA:
undetectable		 2j7xA-2zkjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 GLU A 373
LEU A  35
ARG A  64
ILE A 179
GLY A  44
 None
 1.29A 2j7xA-2zkjA:
undetectable		 2j7xA-2zkjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 LEU A 172
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.28A 2j7xA-2zkjA:
undetectable		 2j7xA-2zkjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		5 LEU A 330
LEU A 379
ILE A 357
GLY A 372
LEU A 374
 None
 1.21A 2j7xA-3axiA:
undetectable		 2j7xA-3axiA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 326
LEU A 311
ILE A 435
GLY A 316
LEU A 318
 None
 1.04A 2j7xA-3d1jA:
undetectable		 2j7xA-3d1jA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 LEU A 392
GLU A 344
LEU A  73
ILE A 377
GLY A 359
 None
 1.25A 2j7xA-3djdA:
undetectable		 2j7xA-3djdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		5 LEU A 120
LEU A 121
ILE A  92
HIS A  53
LEU A  54
 None
 1.29A 2j7xA-3dkaA:
undetectable		 2j7xA-3dkaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M)
PF17193
(MukF_C) 		5 MET A 178
LEU A 208
LEU A 207
GLY A 213
LEU A 215
 None
 1.22A 2j7xA-3euhA:
undetectable		 2j7xA-3euhA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix6 THYMIDYLATE SYNTHASE

(Brucella
melitensis) 		PF00303
(Thymidylat_synt) 		5 LEU A  45
LEU A   5
LEU A   7
ILE A 208
HIS A 212
 None
 1.00A 2j7xA-3ix6A:
undetectable		 2j7xA-3ix6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 118
LEU A 344
ILE A 301
GLY A 300
LEU A 265
 None
 1.09A 2j7xA-3kumA:
undetectable		 2j7xA-3kumA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7

(Streptomyces
avermitilis) 		PF03259
(Robl_LC7) 		5 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.23A 2j7xA-3kyeA:
undetectable		 2j7xA-3kyeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		5 MET B 593
LEU B 634
LEU B 554
LEU B 552
GLY B 618
 None
 1.10A 2j7xA-3l91B:
undetectable		 2j7xA-3l91B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE

(Neurospora
crassa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 197
LEU A 165
ILE A 282
GLY A 171
LEU A 172
 None
 1.12A 2j7xA-3m6iA:
undetectable		 2j7xA-3m6iA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6k VP1 PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 LEU A 249
LEU A 237
ILE A 453
GLY A 264
LEU A 447
 None
 1.20A 2j7xA-3r6kA:
undetectable		 2j7xA-3r6kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcr MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN

(Mycobacteroides
abscessus) 		PF00994
(MoCF_biosynth) 		5 LEU A 162
LEU A  50
ILE A  29
GLY A  43
LEU A  45
 None
 1.23A 2j7xA-3tcrA:
undetectable		 2j7xA-3tcrA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		5 LEU A 328
LEU A 320
GLY A 302
HIS A 299
LEU A 300
 None
 1.30A 2j7xA-3tp9A:
undetectable		 2j7xA-3tp9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1j PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		5 LEU A   5
ILE A  13
GLY A  18
HIS A  17
LEU A  20
 None
None
DMS  A 208 (-3.5A)
ACO  A 201 (-4.1A)
None
 1.18A 2j7xA-3x1jA:
undetectable		 2j7xA-3x1jA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 314
MET A 436
LEU A 435
ILE A 196
GLY A 193
 None
 1.14A 2j7xA-4ayxA:
undetectable		 2j7xA-4ayxA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 LEU A 383
LEU A 272
ILE A 410
GLY A 266
LEU A 265
 None
 1.17A 2j7xA-4c9mA:
3.2		 2j7xA-4c9mA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 LEU A 160
LEU A 241
ILE A 152
GLY A 133
LEU A 134
 None
 1.08A 2j7xA-4ccwA:
undetectable		 2j7xA-4ccwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 5 LEU A 262
LEU A 263
ILE A 116
GLY A 113
LEU A 283
 None
 1.23A 2j7xA-4egvA:
undetectable		 2j7xA-4egvA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhj MIF4G
DOMAIN-CONTAINING
PROTEIN B

(Danio rerio) 		PF02854
(MIF4G) 		5 GLU A 147
LEU A 136
LEU A 142
ILE A 198
HIS A 156
 None
 1.27A 2j7xA-4jhjA:
undetectable		 2j7xA-4jhjA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLU A3143
LEU A3257
MET A3258
GLY A3293
HIS A3404
 None
 1.06A 2j7xA-4kc5A:
undetectable		 2j7xA-4kc5A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Rattus
norvegicus) 		PF00777
(Glyco_transf_29) 		5 MET A 328
LEU A 323
MET A 149
LEU A 293
ILE A 250
 None
 1.20A 2j7xA-4mpsA:
undetectable		 2j7xA-4mpsA:
24.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 286
GLU A 290
LEU A 324
ARG A 331
ILE A 361
GLY A 444
 None
 1.41A 2j7xA-4n1yA:
30.7		 2j7xA-4n1yA:
39.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 286
GLU A 290
MET A 321
LEU A 324
ARG A 331
ILE A 361
GLY A 447
 None
 0.54A 2j7xA-4n1yA:
30.7		 2j7xA-4n1yA:
39.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.22A 2j7xA-4o1oA:
undetectable		 2j7xA-4o1oA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovm UNCHARACTERIZED
PROTEIN SGCJ

(Streptomyces
carzinostaticus) 		PF14534
(DUF4440) 		5 LEU A 132
LEU A  43
ARG A  27
ILE A  64
GLY A  60
 None
 1.23A 2j7xA-4ovmA:
undetectable		 2j7xA-4ovmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A 874
GLU A 559
LEU A 561
ILE A 882
LEU A 955
 None
 1.29A 2j7xA-4ptfA:
undetectable		 2j7xA-4ptfA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
 None
 1.27A 2j7xA-4q5nA:
undetectable		 2j7xA-4q5nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 772
MET A 807
LEU A 810
LEU A 814
ARG A 817
 CV7  A1987 ( 4.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
 0.46A 2j7xA-4udbA:
27.5		 2j7xA-4udbA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		5 LEU A 103
GLU A 133
ILE A  28
GLY A  31
LEU A 413
 None
 1.28A 2j7xA-4wgxA:
undetectable		 2j7xA-4wgxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 GLU A 323
LEU A 321
ILE A 332
GLY A 286
LEU A 287
 None
 1.17A 2j7xA-4xaeA:
undetectable		 2j7xA-4xaeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  53
LEU A  51
ILE A  95
GLY A  58
LEU A  90
 None
 1.27A 2j7xA-4zfhA:
undetectable		 2j7xA-4zfhA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a12 CHLORITE DISMUTASE

(Magnetospirillum
sp.) 		PF06778
(Chlor_dismutase) 		5 LEU A 116
LEU A 185
ARG A 183
ILE A 112
GLY A  19
 HEM  A 250 (-3.8A)
AZI  A 251 ( 4.0A)
AZI  A 251 ( 3.8A)
None
None
 1.28A 2j7xA-5a12A:
undetectable		 2j7xA-5a12A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		5 LEU A 276
LEU A 339
ILE A 285
GLY A 284
LEU A 282
 None
 1.24A 2j7xA-5c65A:
undetectable		 2j7xA-5c65A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A 195
LEU A 196
ILE A 122
GLY A 176
LEU A 177
 None
 1.26A 2j7xA-5ci6A:
undetectable		 2j7xA-5ci6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2f BETA-LACTAMASE YBXI

(Bacillus
subtilis) 		PF00905
(Transpeptidase) 		5 LEU A  84
LEU A 179
ILE A 170
GLY A 151
LEU A 145
 None
 1.24A 2j7xA-5e2fA:
undetectable		 2j7xA-5e2fA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 LEU A  24
LEU A  60
LEU A 101
GLY A  93
LEU A  89
 None
 1.14A 2j7xA-5e7pA:
undetectable		 2j7xA-5e7pA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		5 LEU A 316
ILE A 325
GLY A 246
HIS A 250
LEU A 247
 None
None
None
OLA  A1209 (-3.8A)
None
 1.22A 2j7xA-5ee7A:
undetectable		 2j7xA-5ee7A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1

(Homo sapiens) 		PF00083
(Sugar_tr) 		5 LEU A 278
LEU A 341
ILE A 287
GLY A 286
LEU A 284
 None
 1.27A 2j7xA-5eqiA:
undetectable		 2j7xA-5eqiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 5 MET C 233
GLU C 201
MET C 212
GLY C 106
LEU C 103
 HEM  C 502 (-3.7A)
None
None
None
None
 1.13A 2j7xA-5ex6C:
2.4		 2j7xA-5ex6C:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 LEU A 249
LEU A 237
ILE A 458
GLY A 264
LEU A 452
 None
 1.17A 2j7xA-5f4jA:
undetectable		 2j7xA-5f4jA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		5 LEU A 103
LEU A 109
ILE A  20
GLY A  12
LEU A  39
 None
None
None
UDP  A 502 (-3.0A)
None
 0.93A 2j7xA-5gvvA:
undetectable		 2j7xA-5gvvA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2a KLLA0C04147P

(Kluyveromyces
lactis) 		PF00023
(Ank) 		5 LEU A 212
LEU A 175
ILE A 190
GLY A 221
LEU A 218
 None
 1.16A 2j7xA-5h2aA:
undetectable		 2j7xA-5h2aA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 207
LEU A 194
LEU A 197
GLY A 251
LEU A 249
 None
 1.01A 2j7xA-5ijbA:
undetectable		 2j7xA-5ijbA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd3 LAE5

(uncultured
bacterium) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 158
MET A 159
ARG A 165
ILE A  90
GLY A  91
 None
 1.04A 2j7xA-5jd3A:
undetectable		 2j7xA-5jd3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		PF02201
(SWIB) 		5 LEU A  38
LEU A  37
ILE A  61
GLY A  58
LEU A  54
 None
None
6SJ  A 201 (-3.6A)
6SJ  A 201 ( 3.8A)
6SJ  A 201 (-4.2A)
 1.12A 2j7xA-5lawA:
undetectable		 2j7xA-5lawA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx0 DIPEPTIDASE

(Aspergillus
fumigatus) 		PF01244
(Peptidase_M19) 		5 LEU A 201
MET A 197
LEU A 192
ILE A 133
GLY A 132
 None
 1.16A 2j7xA-5lx0A:
undetectable		 2j7xA-5lx0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
 None
 1.10A 2j7xA-5m5pA:
undetectable		 2j7xA-5m5pA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 LEU B 191
MET B 201
LEU B 206
GLY B  46
LEU B  44
 None
 1.25A 2j7xA-5my0B:
undetectable		 2j7xA-5my0B:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		5 LEU A 493
LEU A 132
LEU A 134
ILE A  39
LEU A 177
 None
 1.22A 2j7xA-5n6mA:
undetectable		 2j7xA-5n6mA:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 294
LEU A 301
GLU A 305
MET A 340
LEU A 343
ARG A 346
 None
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
 1.12A 2j7xA-5toaA:
33.7		 2j7xA-5toaA:
89.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 MET A 295
LEU A 301
GLU A 305
MET A 336
LEU A 339
MET A 340
LEU A 343
ARG A 346
ILE A 376
GLY A 472
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.0A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 0.40A 2j7xA-5toaA:
33.7		 2j7xA-5toaA:
89.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 295
LEU A 354
ILE A 376
GLY A 472
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.0A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 1.26A 2j7xA-5toaA:
33.7		 2j7xA-5toaA:
89.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 LEU A  96
GLU A 168
LEU A 195
ILE A  39
LEU A  34
 None
 1.09A 2j7xA-5u4hA:
undetectable		 2j7xA-5u4hA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		5 MET A 377
LEU A 418
LEU A 338
LEU A 336
GLY A 402
 None
 1.09A 2j7xA-5ubkA:
undetectable		 2j7xA-5ubkA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 MET A  74
LEU A  30
LEU A  35
ILE A 376
GLY A 135
 None
 1.20A 2j7xA-5x2qA:
undetectable		 2j7xA-5x2qA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xx9 BACTERIOFERRITIN

(Streptomyces
coelicolor) 		no annotation 5 LEU A  19
LEU A  58
ILE A   8
GLY A  67
LEU A  68
 None
 1.14A 2j7xA-5xx9A:
undetectable		 2j7xA-5xx9A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq5 OSTEOMODULIN

(Homo sapiens) 		no annotation 5 MET A 182
LEU A 164
LEU A 168
LEU A 148
ILE A 174
 None
 1.18A 2j7xA-5yq5A:
undetectable		 2j7xA-5yq5A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 MET A 212
LEU A 237
ILE A 184
GLY A 180
HIS A 183
 None
None
None
GOL  A 406 ( 3.6A)
None
 1.29A 2j7xA-6c49A:
undetectable		 2j7xA-6c49A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-) 		no annotation 5 LEU A  65
MET A  62
LEU A  63
ILE A  83
GLY A  80
 None
 0.98A 2j7xA-6c7vA:
undetectable		 2j7xA-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-) 		no annotation 5 LEU A  65
MET A  62
LEU A  63
ILE A  83
GLY A  81
 None
 1.22A 2j7xA-6c7vA:
undetectable		 2j7xA-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 5 LEU A 277
LEU A 270
ILE A 321
GLY A 307
LEU A 303
 None
 1.30A 2j7xA-6fuyA:
undetectable		 2j7xA-6fuyA:
16.08