SIMILAR PATTERNS OF AMINO ACIDS FOR 2J2P_F_SC2F1290

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1

(Rattus
norvegicus) 		PF01161
(PBP) 		4 ARG A  26
ASP A  35
THR A  33
LYS A   2
 None
 0.90A 2j2pF-2iqxA:
0.0		 2j2pF-2iqxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygt DELTA TOXIN

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 ARG A 287
ASP A 280
THR A 285
LYS A 239
 IMD  A1293 (-4.3A)
None
None
None
 1.30A 2j2pF-2ygtA:
0.0		 2j2pF-2ygtA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		4 ARG A  53
ASP A  54
THR A  50
LYS A  57
 None
 1.33A 2j2pF-3nfvA:
0.0		 2j2pF-3nfvA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r9j FICOLIN-2

(Homo sapiens) 		no annotation 4 ARG G 132
ASP G 133
THR G 136
LYS G 221
 SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
 0.30A 2j2pF-4r9jG:
40.0		 2j2pF-4r9jG:
99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 ARG C1786
ASP C1787
THR C1783
LYS C1790
 None
 1.15A 2j2pF-6fikC:
undetectable		 2j2pF-6fikC:
21.21