SIMILAR PATTERNS OF AMINO ACIDS FOR 2J2P_E_SC2E1291

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		4 ASP A  94
LEU A 111
GLY A  92
ARG A  23
 CTP  A 130 (-3.9A)
None
CTP  A 130 (-3.3A)
None
 1.44A 2j2pD-1cozA:
0.0
2j2pE-1cozA:
0.0		 2j2pD-1cozA:
20.18
2j2pE-1cozA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ASP A1002
LEU A 994
GLY A 995
ARG A 766
 None
 1.00A 2j2pD-1yq2A:
0.0
2j2pE-1yq2A:
0.4		 2j2pD-1yq2A:
12.39
2j2pE-1yq2A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 ASP A 353
LEU A 361
GLY A 362
ARG A 338
 None
 1.39A 2j2pD-1z3zA:
0.0
2j2pE-1z3zA:
0.0		 2j2pD-1z3zA:
18.79
2j2pE-1z3zA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivy HYPOTHETICAL PROTEIN
SSO1404

(Sulfolobus
solfataricus) 		PF09827
(CRISPR_Cas2) 		4 ASP A  30
LEU A  41
GLY A  39
ARG A  45
 None
 1.28A 2j2pD-2ivyA:
0.0
2j2pE-2ivyA:
0.0		 2j2pD-2ivyA:
19.70
2j2pE-2ivyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jay PROTEASOME

(Mycobacterium
tuberculosis) 		PF00227
(Proteasome) 		4 ASP A 216
LEU A 221
GLY A 220
ARG A 266
 None
 1.46A 2j2pD-2jayA:
0.0
2j2pE-2jayA:
0.0		 2j2pD-2jayA:
22.04
2j2pE-2jayA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq1 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2) 		4 ASP A   5
LEU A  45
GLY A  46
ARG A 121
 None
 1.19A 2j2pD-2oq1A:
0.0
2j2pE-2oq1A:
0.0		 2j2pD-2oq1A:
19.25
2j2pE-2oq1A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 ASP A   6
LEU A 156
GLY A 157
ARG A 127
 None
 1.36A 2j2pD-2rgjA:
0.0
2j2pE-2rgjA:
0.0		 2j2pD-2rgjA:
19.18
2j2pE-2rgjA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE

(Rhodospirillum
rubrum) 		PF03747
(ADP_ribosyl_GH) 		4 ASP A   8
LEU A  15
GLY A  12
ARG A 281
 None
 1.32A 2j2pD-2wocA:
undetectable
2j2pE-2wocA:
undetectable		 2j2pD-2wocA:
22.48
2j2pE-2wocA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR

(Homo sapiens) 		no annotation 4 ASP A 591
LEU A 606
GLY A 605
ARG A 610
 None
 1.47A 2j2pD-2xocA:
0.0
2j2pE-2xocA:
0.0		 2j2pD-2xocA:
20.88
2j2pE-2xocA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 ASP A 170
LEU A 177
GLY A 173
ARG A 145
 None
 1.38A 2j2pD-2yz2A:
0.0
2j2pE-2yz2A:
0.0		 2j2pD-2yz2A:
20.22
2j2pE-2yz2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 ASP A 338
LEU A 299
GLY A 295
ARG A 311
 None
 1.43A 2j2pD-2zpaA:
undetectable
2j2pE-2zpaA:
undetectable		 2j2pD-2zpaA:
17.05
2j2pE-2zpaA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 ASP A 338
LEU A 300
GLY A 297
ARG A 311
 None
 1.44A 2j2pD-2zpaA:
undetectable
2j2pE-2zpaA:
undetectable		 2j2pD-2zpaA:
17.05
2j2pE-2zpaA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		4 ASP A 171
LEU A 167
GLY A 169
ARG A 178
 None
 1.30A 2j2pD-3da8A:
undetectable
2j2pE-3da8A:
undetectable		 2j2pD-3da8A:
21.63
2j2pE-3da8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh0 SAM DEPENDENT
METHYLTRANSFERASE

(Aquifex
aeolicus) 		PF13847
(Methyltransf_31) 		4 ASP A  43
LEU A  15
GLY A  47
ARG A  20
 None
SAM  A 220 (-4.0A)
SAM  A 220 ( 3.7A)
SAM  A 220 (-2.9A)
 1.32A 2j2pD-3dh0A:
undetectable
2j2pE-3dh0A:
undetectable		 2j2pD-3dh0A:
17.11
2j2pE-3dh0A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11)
PF14710
(Nitr_red_alph_N)
PF14711
(Nitr_red_bet_C) 		4 ASP B 379
LEU B 371
GLY B 375
ARG A 520
 None
 1.36A 2j2pD-3egwB:
undetectable
2j2pE-3egwB:
undetectable		 2j2pD-3egwB:
17.96
2j2pE-3egwB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehc SNOAL-LIKE
POLYKETIDE CYCLASE

(Agrobacterium
fabrum) 		PF07366
(SnoaL) 		4 ASP A  29
LEU A  23
GLY A  24
ARG A  44
 None
 1.24A 2j2pD-3ehcA:
undetectable
2j2pE-3ehcA:
undetectable		 2j2pD-3ehcA:
22.54
2j2pE-3ehcA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		4 ASP A 245
LEU A  79
GLY A  81
ARG A 138
 None
 1.45A 2j2pD-3hgqA:
undetectable
2j2pE-3hgqA:
undetectable		 2j2pD-3hgqA:
20.30
2j2pE-3hgqA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus) 		PF00329
(Complex1_30kDa) 		4 ASP 5  19
LEU 5  22
GLY 5  23
ARG 5 193
 None
 1.27A 2j2pD-3i9v5:
undetectable
2j2pE-3i9v5:
undetectable		 2j2pD-3i9v5:
20.92
2j2pE-3i9v5:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 ASP B1089
LEU B1086
GLY B1087
ARG B 947
 None
 1.48A 2j2pD-3k70B:
undetectable
2j2pE-3k70B:
undetectable		 2j2pD-3k70B:
10.34
2j2pE-3k70B:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 ASP A 279
LEU A 724
GLY A 723
ARG A 254
 None
 1.16A 2j2pD-3pieA:
undetectable
2j2pE-3pieA:
undetectable		 2j2pD-3pieA:
11.25
2j2pE-3pieA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		4 ASP A  56
LEU A 250
GLY A 249
ARG A  21
 None
 1.42A 2j2pD-3qboA:
undetectable
2j2pE-3qboA:
undetectable		 2j2pD-3qboA:
20.05
2j2pE-3qboA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 ASP A 115
LEU A 147
GLY A 149
ARG A 145
 None
 1.44A 2j2pD-3s8mA:
undetectable
2j2pE-3s8mA:
undetectable		 2j2pD-3s8mA:
18.10
2j2pE-3s8mA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		4 ASP A  70
LEU A  77
GLY A  76
ARG A  44
 SAH  A1689 ( 4.4A)
SAH  A1689 ( 4.5A)
None
SAH  A1689 (-2.7A)
 1.18A 2j2pD-4c4aA:
undetectable
2j2pE-4c4aA:
undetectable		 2j2pD-4c4aA:
15.20
2j2pE-4c4aA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR

(Thermoproteus
tenax) 		no annotation 4 ASP A  79
LEU A  76
GLY A  73
ARG A 114
 None
 1.31A 2j2pD-4csoA:
undetectable
2j2pE-4csoA:
undetectable		 2j2pD-4csoA:
19.74
2j2pE-4csoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASP A 446
LEU A 204
GLY A 205
ARG A 313
 None
 1.25A 2j2pD-4g1pA:
undetectable
2j2pE-4g1pA:
undetectable		 2j2pD-4g1pA:
19.75
2j2pE-4g1pA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6z GLUTAMATE-TRNA
LIGASE

(Burkholderia
thailandensis) 		PF00749
(tRNA-synt_1c) 		4 ASP A 208
LEU A 233
GLY A 206
ARG A  23
 None
 1.36A 2j2pD-4g6zA:
undetectable
2j2pE-4g6zA:
undetectable		 2j2pD-4g6zA:
17.74
2j2pE-4g6zA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0x ESAT-6-LIKE PROTEIN
MAB_3112
ESAT-6-LIKE PROTEIN
MAB_3113

(Mycobacteroides
abscessus) 		PF06013
(WXG100) 		4 ASP A   2
LEU A   7
GLY A   5
ARG B  40
 None
 1.26A 2j2pD-4i0xA:
undetectable
2j2pE-4i0xA:
undetectable		 2j2pD-4i0xA:
16.06
2j2pE-4i0xA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF15890
(Peptidase_Mx1) 		4 ASP A 224
LEU A 210
GLY A 211
ARG A 202
 None
 0.88A 2j2pD-4l7aA:
undetectable
2j2pE-4l7aA:
undetectable		 2j2pD-4l7aA:
19.23
2j2pE-4l7aA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7j 30S RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00575
(S1) 		4 ASP D 143
LEU D 135
GLY D 133
ARG D 171
 None
 1.29A 2j2pD-4q7jD:
undetectable
2j2pE-4q7jD:
undetectable		 2j2pD-4q7jD:
22.81
2j2pE-4q7jD:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens) 		no annotation 4 ASP C 222
LEU C 254
GLY C 250
ARG C 258
 None
 1.31A 2j2pD-4rwtC:
undetectable
2j2pE-4rwtC:
undetectable		 2j2pD-4rwtC:
17.22
2j2pE-4rwtC:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		4 ASP A  53
LEU A  19
GLY A  22
ARG A  29
 None
 1.11A 2j2pD-4rzzA:
undetectable
2j2pE-4rzzA:
undetectable		 2j2pD-4rzzA:
17.96
2j2pE-4rzzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)

(Homo sapiens) 		no annotation 4 ASP A 373
LEU A 405
GLY A 401
ARG A 409
 None
None
None
CL  A 507 (-4.1A)
 1.25A 2j2pD-4z79A:
undetectable
2j2pE-4z79A:
undetectable		 2j2pD-4z79A:
19.82
2j2pE-4z79A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)

(Homo sapiens) 		no annotation 4 ASP A 373
LEU A 405
GLY A 401
ARG A 409
 None
 1.30A 2j2pD-4z8gA:
undetectable
2j2pE-4z8gA:
undetectable		 2j2pD-4z8gA:
17.37
2j2pE-4z8gA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		4 ASP G1373
LEU G1405
GLY G1401
ARG G1409
 None
 1.14A 2j2pD-4z94G:
undetectable
2j2pE-4z94G:
undetectable		 2j2pD-4z94G:
21.85
2j2pE-4z94G:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT
PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ASP A 210
LEU C 104
GLY C 107
ARG A   9
 None
None
FES  C 202 (-4.2A)
None
 1.44A 2j2pD-4zohA:
undetectable
2j2pE-4zohA:
undetectable		 2j2pD-4zohA:
16.12
2j2pE-4zohA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		4 ASP A 128
LEU A 139
GLY A 135
ARG A  99
 None
 1.38A 2j2pD-5allA:
undetectable
2j2pE-5allA:
undetectable		 2j2pD-5allA:
15.90
2j2pE-5allA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 ASP A 633
LEU A 640
GLY A 637
ARG A 624
 None
 1.26A 2j2pD-5e3cA:
undetectable
2j2pE-5e3cA:
undetectable		 2j2pD-5e3cA:
13.20
2j2pE-5e3cA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		4 ASP A 192
LEU A 336
GLY A 337
ARG A 291
 None
 1.24A 2j2pD-5eksA:
undetectable
2j2pE-5eksA:
undetectable		 2j2pD-5eksA:
21.87
2j2pE-5eksA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1q PERIPLASMIC
DIPEPTIDE TRANSPORT
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 ASP A 451
LEU A 151
GLY A 149
ARG A 169
 GOL  A 602 (-2.7A)
None
None
GOL  A 602 ( 4.3A)
 1.42A 2j2pD-5f1qA:
undetectable
2j2pE-5f1qA:
undetectable		 2j2pD-5f1qA:
18.20
2j2pE-5f1qA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 4 ASP B 275
LEU B 304
GLY B 273
ARG B  62
 None
 1.31A 2j2pD-5fbhB:
undetectable
2j2pE-5fbhB:
undetectable		 2j2pD-5fbhB:
17.89
2j2pE-5fbhB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		4 ASP A 252
LEU A 339
GLY A 340
ARG A  48
 None
 0.84A 2j2pD-5fqlA:
undetectable
2j2pE-5fqlA:
undetectable		 2j2pD-5fqlA:
16.42
2j2pE-5fqlA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		4 ASP A 309
LEU A 255
GLY A 323
ARG A 316
 None
 1.38A 2j2pD-5jy9A:
undetectable
2j2pE-5jy9A:
undetectable		 2j2pD-5jy9A:
17.23
2j2pE-5jy9A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE

(Arabidopsis
thaliana) 		PF03254
(XG_FTase) 		4 ASP A  95
LEU A 101
GLY A 100
ARG A 333
 None
 1.11A 2j2pD-5kx6A:
undetectable
2j2pE-5kx6A:
undetectable		 2j2pD-5kx6A:
18.12
2j2pE-5kx6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv8 EF-P ARGININE 32
RHAMNOSYL-TRANSFERAS
E

(Pseudomonas
putida) 		PF10093
(DUF2331) 		4 ASP A 364
LEU A 156
GLY A 154
ARG A 278
 None
 1.20A 2j2pD-5nv8A:
undetectable
2j2pE-5nv8A:
undetectable		 2j2pD-5nv8A:
18.58
2j2pE-5nv8A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u22 N2152

(Neocallimastix
frontalis) 		PF01229
(Glyco_hydro_39) 		4 ASP A 304
LEU A  55
GLY A 295
ARG A  98
 None
 1.20A 2j2pD-5u22A:
undetectable
2j2pE-5u22A:
undetectable		 2j2pD-5u22A:
20.75
2j2pE-5u22A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 4 ASP A 168
LEU A 808
GLY A 809
ARG A 816
 None
 1.14A 2j2pD-5vhaA:
undetectable
2j2pE-5vhaA:
undetectable		 2j2pD-5vhaA:
17.26
2j2pE-5vhaA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		4 ASP A 158
LEU A 205
GLY A 206
ARG A 219
 None
None
None
PGE  A 501 ( 4.9A)
 0.96A 2j2pD-5xd0A:
undetectable
2j2pE-5xd0A:
undetectable		 2j2pD-5xd0A:
21.87
2j2pE-5xd0A:
21.87