SIMILAR PATTERNS OF AMINO ACIDS FOR 2J2P_E_SC2E1290

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bx0 PROTEIN
(FERREDOXIN:NADP+
OXIDOREDUCTASE)

(Spinacia
oleracea) 		PF00175
(NAD_binding_1) 		5 SER A 234
VAL A 233
SER A 209
SER A 208
ASP A  52
 PO4  A 316 (-3.1A)
None
None
None
None
 1.09A 2j2pD-1bx0A:
0.0
2j2pE-1bx0A:
0.0		 2j2pD-1bx0A:
20.50
2j2pE-1bx0A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Thermotoga
maritima) 		PF01513
(NAD_kinase) 		5 VAL A 246
LEU A  78
SER A  80
ARG A 103
GLU A 101
 None
 1.50A 2j2pD-1yt5A:
0.0
2j2pE-1yt5A:
0.0		 2j2pD-1yt5A:
22.11
2j2pE-1yt5A:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2d39 FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 SER A 129
LEU A 145
ASP A 147
ARG A 160
GLU A 320
 None
 0.43A 2j2pD-2d39A:
33.0
2j2pE-2d39A:
33.1		 2j2pD-2d39A:
81.65
2j2pE-2d39A:
81.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		5 SER A 155
VAL A 151
LEU A 170
SER A 174
LEU A 189
 None
 1.49A 2j2pD-2gw1A:
undetectable
2j2pE-2gw1A:
undetectable		 2j2pD-2gw1A:
17.94
2j2pE-2gw1A:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnp FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 SER F 100
LEU F 116
ASP F 118
ARG F 131
GLU F 291
 None
 0.49A 2j2pD-2wnpF:
39.6
2j2pE-2wnpF:
40.5		 2j2pD-2wnpF:
83.49
2j2pE-2wnpF:
83.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD

(Escherichia
coli) 		PF02613
(Nitrate_red_del) 		5 VAL A  97
LEU A 104
SER A 102
ASP A 126
ARG A 107
 None
 1.31A 2j2pD-3u41A:
undetectable
2j2pE-3u41A:
undetectable		 2j2pD-3u41A:
20.08
2j2pE-3u41A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 VAL A 349
LEU A  31
SER A   5
LEU A  25
ASP A  28
 None
 1.49A 2j2pD-3v7nA:
0.0
2j2pE-3v7nA:
0.0		 2j2pD-3v7nA:
17.96
2j2pE-3v7nA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		5 SER A 208
VAL A 213
LEU A  68
SER A 230
LEU A 119
 None
 1.50A 2j2pD-4e4jA:
0.0
2j2pE-4e4jA:
0.0		 2j2pD-4e4jA:
18.45
2j2pE-4e4jA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		5 SER A  70
LEU A  44
LEU A  77
ARG A  49
GLU A  76
 None
 1.09A 2j2pD-4otkA:
0.0
2j2pE-4otkA:
0.0		 2j2pD-4otkA:
21.77
2j2pE-4otkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 SER A 424
VAL A 425
SER A 472
LEU A 428
GLU A 400
 None
 1.26A 2j2pD-4qyjA:
0.0
2j2pE-4qyjA:
0.0		 2j2pD-4qyjA:
17.98
2j2pE-4qyjA:
17.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r9j FICOLIN-2

(Homo sapiens) 		no annotation 5 SER G  91
LEU G 107
ASP G 109
ARG G 122
GLU G 282
 None
 0.23A 2j2pD-4r9jG:
40.1
2j2pE-4r9jG:
41.1		 2j2pD-4r9jG:
99.08
2j2pE-4r9jG:
99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		5 VAL A 453
SER A 538
LEU A 192
ASP A 503
GLU A 506
 None
CA  A 802 ( 4.9A)
None
CA  A 801 (-3.3A)
CA  A 801 ( 3.1A)
 1.06A 2j2pD-4wisA:
undetectable
2j2pE-4wisA:
undetectable		 2j2pD-4wisA:
14.70
2j2pE-4wisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 5 SER A  30
LEU A  31
SER A  27
LEU A  60
ASP A  55
 None
 1.35A 2j2pD-5a7yA:
undetectable
2j2pE-5a7yA:
undetectable		 2j2pD-5a7yA:
20.94
2j2pE-5a7yA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c98 AGAP007691-PB

(Anopheles
gambiae) 		PF00079
(Serpin) 		5 SER A 171
SER A 145
LEU A 111
ASP A 138
GLU A 113
 None
 1.37A 2j2pD-5c98A:
undetectable
2j2pE-5c98A:
undetectable		 2j2pD-5c98A:
20.28
2j2pE-5c98A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		5 SER A 436
SER A 603
LEU A 606
LEU A 472
GLU A 469
 None
 1.27A 2j2pD-5i85A:
undetectable
2j2pE-5i85A:
undetectable		 2j2pD-5i85A:
16.58
2j2pE-5i85A:
16.58