SIMILAR PATTERNS OF AMINO ACIDS FOR 2J0D_A_ERYA1498

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 ARG A  83
ILE A  80
ILE A 235
ALA A 270
GLU A 240
 None
 1.04A 2j0dA-1c0nA:
0.0		 2j0dA-1c0nA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjl PROCATHEPSIN L

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 ILE A 211
ALA A 125
THR A 128
ALA A   1
ARG A   3
 None
 0.88A 2j0dA-1cjlA:
0.0		 2j0dA-1cjlA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		5 PHE A 162
ILE A 558
ALA A 546
THR A 490
GLU A 158
 None
 1.12A 2j0dA-1e8tA:
0.0		 2j0dA-1e8tA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ew3 ALLERGEN EQU C 1

(Equus caballus) 		PF00061
(Lipocalin) 		5 ILE A  25
ILE A 156
PHE A 136
ALA A 140
ARG A 141
 None
 1.18A 2j0dA-1ew3A:
undetectable		 2j0dA-1ew3A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE

(Rattus
norvegicus) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 ILE A 201
ILE A 283
ALA A 250
THR A 254
ALA A 219
 None
None
AGS  A1383 ( 4.6A)
None
None
 1.18A 2j0dA-1gjvA:
0.6		 2j0dA-1gjvA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjo NEUROSERPIN
NEUROSERPIN

(Mus musculus;
Mus musculus) 		PF00079
(Serpin)
PF00079
(Serpin) 		5 ARG C 290
PHE C 291
ILE C 338
ILE E 374
GLU C 342
 None
 1.09A 2j0dA-1jjoC:
0.0		 2j0dA-1jjoC:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 PHE A 769
ILE A 807
ILE A 835
ALA A 833
THR A 831
 None
 1.18A 2j0dA-1k32A:
0.0		 2j0dA-1k32A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjn MTH0777

(Methanothermobacter
thermautotrophicus) 		PF09001
(DUF1890) 		5 PHE A 111
PHE A  98
ALA A  99
THR A 106
ALA A 108
 None
 1.15A 2j0dA-1kjnA:
0.0		 2j0dA-1kjnA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 PHE A 192
PHE A 170
ILE A 137
ALA A 144
ALA A 406
 None
 1.19A 2j0dA-1l6jA:
undetectable		 2j0dA-1l6jA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		5 SER A  66
ILE A  47
ILE A 112
THR A  29
ALA A  31
 None
 1.18A 2j0dA-1ne2A:
undetectable		 2j0dA-1ne2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouu HEMOGLOBIN I

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		5 SER A 103
ILE A 106
PHE A 129
ALA A 131
ALA A 138
 None
 1.08A 2j0dA-1ouuA:
undetectable		 2j0dA-1ouuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		6 ILE A  27
ILE A  89
ALA A  85
THR A  81
ARG A  33
GLU A  31
 None
 1.48A 2j0dA-1r6vA:
undetectable		 2j0dA-1r6vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A  90
ILE A  80
ALA A  51
ARG A 127
GLU A 129
 None
 1.11A 2j0dA-1svdA:
undetectable		 2j0dA-1svdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ARG A 442
ILE A 499
ILE A 416
PHE A 417
ALA A 343
 None
None
None
None
MEI  A1001 (-3.3A)
 1.18A 2j0dA-1uhlA:
undetectable		 2j0dA-1uhlA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4u HEMOGLOBIN ALPHA
CHAIN

(Thunnus thynnus) 		PF00042
(Globin) 		5 SER A 104
ILE A 107
PHE A 130
ALA A 132
ALA A 139
 HEM  A 144 ( 4.9A)
None
None
None
None
 1.12A 2j0dA-1v4uA:
undetectable		 2j0dA-1v4uA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrm HYPOTHETICAL PROTEIN
TM1553

(Thermotoga
maritima) 		PF02424
(ApbE) 		5 PHE A 346
ILE A 277
ALA A 304
THR A 301
ALA A 329
 None
UNL  A   4 ( 4.0A)
None
None
None
 1.10A 2j0dA-1vrmA:
undetectable		 2j0dA-1vrmA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 ILE A 174
ILE A 216
ALA A 307
ALA A 314
GLU A 183
 None
 1.19A 2j0dA-1wy0A:
undetectable		 2j0dA-1wy0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ARG A 371
ILE A 428
ILE A 345
PHE A 346
ALA A 272
 None
None
9CR  A 801 ( 4.5A)
None
9CR  A 801 (-3.5A)
 1.04A 2j0dA-1xlsA:
undetectable		 2j0dA-1xlsA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  76
ILE A 107
ALA A 109
THR A 301
ALA A 295
 None
 1.09A 2j0dA-2ebdA:
undetectable		 2j0dA-2ebdA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		5 ARG A 266
ILE A 129
ILE A 197
ALA A 101
GLU A  99
 None
 1.18A 2j0dA-2fwrA:
undetectable		 2j0dA-2fwrA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 5 PHE A 197
PHE A 145
ILE A 123
ALA A   8
ARG A 177
 None
 1.17A 2j0dA-2gjuA:
undetectable		 2j0dA-2gjuA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3x CHROMATIN
MODIFICATION-RELATED
PROTEIN EAF3

(Saccharomyces
cerevisiae) 		PF11717
(Tudor-knot) 		5 ILE A  97
ILE A  27
PHE A   8
ALA A   9
GLU A 103
 None
 1.16A 2j0dA-2k3xA:
undetectable		 2j0dA-2k3xA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m38 ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00640
(PID) 		5 PHE A 125
PHE A  75
ILE A  92
ALA A  95
ALA A 130
 None
 1.15A 2j0dA-2m38A:
undetectable		 2j0dA-2m38A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		5 PHE A 244
ILE A  29
ILE A  27
ALA A 315
ALA A 209
 None
 1.19A 2j0dA-2ppvA:
undetectable		 2j0dA-2ppvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 ARG A 467
SER A 478
ILE A 488
ILE A 533
ALA A 411
 None
 0.97A 2j0dA-2vlcA:
undetectable		 2j0dA-2vlcA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		5 ARG A  80
ILE A  72
PHE A 184
ALA A 186
GLU A 123
 None
 1.10A 2j0dA-2x1iA:
undetectable		 2j0dA-2x1iA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA

(Methanocaldococcus
jannaschii) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 PHE A 113
PHE A  77
ILE A  40
ALA A  16
ALA A  90
 None
 1.11A 2j0dA-2yv1A:
undetectable		 2j0dA-2yv1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 ARG A 373
ILE A 325
ALA A 307
ALA A 381
GLU A 377
 None
 1.20A 2j0dA-2yylA:
undetectable		 2j0dA-2yylA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 ARG A 373
ILE A 325
ILE A 322
ALA A 307
ALA A 381
 None
 1.10A 2j0dA-2yylA:
undetectable		 2j0dA-2yylA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74

(Saccharomyces
cerevisiae) 		PF05719
(GPP34) 		5 PHE A 291
ALA A 332
ALA A 105
ARG A 107
GLU A 103
 None
 1.20A 2j0dA-2ziiA:
undetectable		 2j0dA-2ziiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zym SOLUTE-BINDING
PROTEIN

(Thermoactinomyces
vulgaris) 		PF13416
(SBP_bac_8) 		5 ILE A 252
ILE A 134
ALA A 132
THR A 277
ALA A 344
 None
 1.18A 2j0dA-2zymA:
undetectable		 2j0dA-2zymA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 ARG A 315
PHE A 314
ILE A  90
ILE A 120
ALA A 117
 None
 1.16A 2j0dA-3b05A:
undetectable		 2j0dA-3b05A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brk GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00483
(NTP_transferase) 		5 ARG X 402
PHE X 400
ILE X 410
ILE X 383
ALA X 370
 None
 1.04A 2j0dA-3brkX:
undetectable		 2j0dA-3brkX:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dea CUTINASE

(Colletotrichum
gloeosporioides) 		PF01083
(Cutinase) 		5 ARG A 116
ILE A 153
ILE A 157
ALA A  54
GLU A 113
 None
 1.15A 2j0dA-3deaA:
undetectable		 2j0dA-3deaA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ARG A 365
ILE A   6
ILE A 177
ALA A 354
GLU A  20
 None
 0.97A 2j0dA-3e60A:
undetectable		 2j0dA-3e60A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A1260
ILE A1239
PHE A1194
ALA A1193
GLU A1220
 None
 0.99A 2j0dA-3greA:
undetectable		 2j0dA-3greA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		5 ILE A 201
PHE A 374
ALA A 370
ALA A 361
GLU A 302
 None
 0.91A 2j0dA-3gseA:
undetectable		 2j0dA-3gseA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ARG A  10
ILE A  26
PHE A  20
ALA A  19
GLU A 319
 None
 1.05A 2j0dA-3hjaA:
undetectable		 2j0dA-3hjaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		5 PHE A 154
ARG A 135
ALA A 268
ARG A 157
GLU A 161
 None
 1.14A 2j0dA-3iu0A:
undetectable		 2j0dA-3iu0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1
PROTEIN VP3

(Enterovirus B;
Enterovirus B) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 PHE B  13
PHE A 178
ILE A  33
ALA B  24
ALA A 117
 None
 1.16A 2j0dA-3j2jB:
undetectable		 2j0dA-3j2jB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 ARG A 557
PHE A 583
ILE A 463
ILE A 467
ARG A 568
 None
 1.05A 2j0dA-3juxA:
undetectable		 2j0dA-3juxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ILE A 166
ALA A 225
ALA A 228
ARG A 230
GLU A 108
 None
None
None
FMN  A 802 (-2.9A)
FMN  A 802 (-2.8A)
 1.19A 2j0dA-3k30A:
undetectable		 2j0dA-3k30A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		5 PHE A  53
SER A  26
ILE A  24
PHE A 242
ALA A 243
 None
 1.19A 2j0dA-3krsA:
undetectable		 2j0dA-3krsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Jannaschia sp.
CCS1) 		PF07848
(PaaX) 		5 ARG A 101
ALA A 184
ALA A 233
ARG A 232
GLU A 225
 None
 1.18A 2j0dA-3l09A:
undetectable		 2j0dA-3l09A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryl PROTEIN VPA1370

(Vibrio
parahaemolyticus) 		no annotation 5 ILE A 315
ALA A 377
ALA A 384
ARG A 306
GLU A 304
 None
 1.20A 2j0dA-3rylA:
undetectable		 2j0dA-3rylA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		5 ARG A 159
ILE A  23
PHE A 120
ALA A 117
GLU A 128
 PO4  A 444 (-4.0A)
None
None
None
None
 1.19A 2j0dA-3s5wA:
undetectable		 2j0dA-3s5wA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 499
ILE A 497
ALA A 338
THR A 154
ALA A 468
 None
None
None
ANP  A 800 (-4.4A)
None
 0.94A 2j0dA-3sqwA:
undetectable		 2j0dA-3sqwA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 499
ILE A 497
ALA A 338
THR A 154
GLU A 447
 None
None
None
ANP  A 800 (-4.4A)
None
 1.18A 2j0dA-3sqwA:
undetectable		 2j0dA-3sqwA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE C1274
ILE C1164
ALA C1281
THR C1286
GLU C 929
 None
 1.15A 2j0dA-3sr6C:
undetectable		 2j0dA-3sr6C:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 ARG A 141
ILE A 416
ILE A 421
ALA A 445
ALA A 164
 None
 1.17A 2j0dA-3upnA:
undetectable		 2j0dA-3upnA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux9 INTERFERON
ALPHA-1/13

(Homo sapiens) 		PF00143
(Interferon) 		5 SER A 151
ILE A 148
PHE A  36
ALA A 119
GLU A  59
 None
 0.76A 2j0dA-3ux9A:
undetectable		 2j0dA-3ux9A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		5 ILE A   9
ILE A  30
ALA A  29
ALA A  43
GLU A  46
 None
 1.16A 2j0dA-3v7pA:
undetectable		 2j0dA-3v7pA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		5 ARG A 127
ILE A 134
ILE A 269
ALA A 583
ARG A 585
 None
 1.14A 2j0dA-3vtaA:
undetectable		 2j0dA-3vtaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		5 PHE A  42
SER A 216
ILE A  11
ILE A  15
ALA A 151
 None
 1.12A 2j0dA-4ckbA:
undetectable		 2j0dA-4ckbA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dci UNCHARACTERIZED
PROTEIN

(Synechococcus
sp. WH 8102) 		PF11068
(YlqD) 		5 ILE A  31
ALA A  27
ALA A  17
ARG A  16
GLU A 110
 None
 1.18A 2j0dA-4dciA:
undetectable		 2j0dA-4dciA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4erd TELOMERASE
ASSOCIATED PROTEIN
P65

(Tetrahymena
thermophila) 		PF08777
(RRM_3) 		5 ARG A 465
PHE A 466
ILE A 381
ILE A 489
ALA A 398
 G  D 121 ( 3.2A)
None
None
None
None
 1.06A 2j0dA-4erdA:
undetectable		 2j0dA-4erdA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fch OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		5 PHE A 352
ARG A 326
ILE A 375
ARG A 350
GLU A 339
 None
GLC  A 405 ( 2.7A)
None
GLC  A 406 (-3.0A)
None
 1.13A 2j0dA-4fchA:
undetectable		 2j0dA-4fchA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		5 PHE A 352
ARG A 326
ILE A 375
ARG A 350
GLU A 339
 None
 1.04A 2j0dA-4femA:
undetectable		 2j0dA-4femA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqu PUTATIVE GLUTATHIONE
TRANSFERASE

(Sphingobium
chlorophenolicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 ARG A 143
ALA A  64
THR A 275
ARG A 230
GLU A 226
 None
 0.94A 2j0dA-4fquA:
undetectable		 2j0dA-4fquA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A 427
ILE A 447
PHE A 451
ALA A 446
ALA A 439
 None
 1.12A 2j0dA-4im7A:
undetectable		 2j0dA-4im7A:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		10 PHE A  57
ARG A 106
PHE A 108
SER A 119
ILE A 120
ILE A 301
PHE A 304
ALA A 370
ARG A 372
GLU A 374
 None
None
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
None
2QH  A 602 (-3.3A)
2QH  A 602 ( 3.1A)
None
2QH  A 602 ( 4.8A)
 0.75A 2j0dA-4ny4A:
54.0		 2j0dA-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		11 PHE A  57
PHE A 108
SER A 119
ILE A 120
ILE A 301
PHE A 304
ALA A 305
THR A 309
ALA A 370
ARG A 372
GLU A 374
 None
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
None
2QH  A 602 (-3.3A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 3.1A)
None
2QH  A 602 ( 4.8A)
 0.89A 2j0dA-4ny4A:
54.0		 2j0dA-4ny4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd4 CYTOCHROME B

(Saccharomyces
cerevisiae) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 ILE C 125
ILE C 299
PHE C 296
ALA C 298
ALA C 280
 AOQ  C4003 ( 4.4A)
AOQ  C4003 (-4.6A)
None
None
None
 1.17A 2j0dA-4pd4C:
1.8		 2j0dA-4pd4C:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qzv SPIKE PROTEIN S1

(Tylonycteris
bat coronavirus
HKU4) 		PF09408
(Spike_rec_bind) 		5 ARG B  91
ILE B  98
ALA B  81
ALA B 116
GLU B  56
 None
 1.18A 2j0dA-4qzvB:
undetectable		 2j0dA-4qzvB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twl DIOSCORIN 5

(Dioscorea
japonica) 		PF00194
(Carb_anhydrase) 		5 PHE A  75
THR A 194
ALA A 125
ARG A 124
GLU A 118
 None
 1.11A 2j0dA-4twlA:
undetectable		 2j0dA-4twlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twl DIOSCORIN 5

(Dioscorea
japonica) 		PF00194
(Carb_anhydrase) 		5 PHE A 182
THR A 194
ALA A 125
ARG A 124
GLU A 118
 None
 1.18A 2j0dA-4twlA:
undetectable		 2j0dA-4twlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 499
ILE A 497
ALA A 338
THR A 154
ALA A 468
 None
None
None
BEF  A 602 (-4.4A)
None
 0.94A 2j0dA-4tz0A:
undetectable		 2j0dA-4tz0A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		5 ILE A 137
ALA A  78
ALA A 557
ARG A 555
GLU A 551
 None
 1.18A 2j0dA-4uirA:
undetectable		 2j0dA-4uirA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 ILE A 643
ILE A 641
ALA A 423
ALA A 221
ARG A 223
 None
 1.20A 2j0dA-4umvA:
undetectable		 2j0dA-4umvA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypg INTERFERON ALPHA-2

(Homo sapiens) 		PF00143
(Interferon) 		5 SER C 150
ILE C 147
PHE C  36
ALA C 118
GLU C  58
 None
 0.97A 2j0dA-4ypgC:
undetectable		 2j0dA-4ypgC:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		5 ARG A 732
ILE A  45
PHE A 737
ALA A 724
THR A 644
 None
 1.12A 2j0dA-5bptA:
undetectable		 2j0dA-5bptA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		5 ARG A 113
ILE A  18
ALA A 144
ARG A 146
GLU A 148
 None
 1.10A 2j0dA-5bt8A:
undetectable		 2j0dA-5bt8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv8 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA)
PF16164
(VWA_N2) 		5 PHE A1299
ILE A1453
ILE A1412
THR A1364
ALA A1317
 None
 1.12A 2j0dA-5bv8A:
undetectable		 2j0dA-5bv8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Colwellia
psychrerythraea) 		PF01791
(DeoC) 		5 SER A 154
ILE A 139
ILE A 165
PHE A 197
GLU A 148
 None
 1.19A 2j0dA-5c5yA:
undetectable		 2j0dA-5c5yA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efr BAMA-BAMD FUSION
PROTEIN

(Rhodothermus
marinus) 		PF07244
(POTRA)
PF13525
(YfiO) 		5 ARG A1145
ILE A1103
ALA A1071
ARG A1114
GLU A1111
 None
 1.19A 2j0dA-5efrA:
undetectable		 2j0dA-5efrA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 PHE A  87
ILE A 225
THR A  96
ARG A  90
GLU A 375
 None
 1.19A 2j0dA-5hm5A:
undetectable		 2j0dA-5hm5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 PHE A 438
ALA A 442
ALA A 291
ARG A 290
GLU A 287
 None
 1.01A 2j0dA-5i4eA:
undetectable		 2j0dA-5i4eA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4h CATHEPSIN L1
CATHEPSIN L1

(Homo sapiens;
Homo sapiens) 		PF00112
(Peptidase_C1)
PF00112
(Peptidase_C1) 		5 ILE B 211
ALA B 125
THR B 128
ALA A   1
ARG A   3
 None
 1.19A 2j0dA-5i4hB:
undetectable		 2j0dA-5i4hB:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgg ALPHA CHAIN

(Acipenser
persicus) 		PF00042
(Globin) 		5 SER A 103
ILE A 106
PHE A 129
ALA A 131
ALA A 138
 HEM  A 201 ( 4.7A)
None
None
None
None
 1.19A 2j0dA-5jggA:
undetectable		 2j0dA-5jggA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnz ALPHA CHAIN

(Acipenser
stellatus) 		PF00042
(Globin) 		5 SER A 103
ILE A 106
PHE A 129
ALA A 131
ALA A 138
 HEM  A 201 ( 4.9A)
None
None
None
None
 1.17A 2j0dA-5jnzA:
undetectable		 2j0dA-5jnzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ARG B1026
ILE B1307
ILE B1195
ALA B1199
THR B1203
 None
 1.14A 2j0dA-5jtwB:
undetectable		 2j0dA-5jtwB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8e ALPHA-N-ARABINOFURAN
OSIDASE

(Weissella
cibaria) 		PF04616
(Glyco_hydro_43) 		5 ARG A  59
ILE A  72
PHE A 107
ALA A 108
GLU A 120
 None
 0.99A 2j0dA-5m8eA:
undetectable		 2j0dA-5m8eA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t13 CYANURIC ACID
AMIDOHYDROLASE

(Enterobacter
cloacae) 		PF09663
(Amido_AtzD_TrzD) 		5 PHE A 120
PHE A  96
ILE A 258
PHE A 159
ALA A 145
 None
 1.01A 2j0dA-5t13A:
undetectable		 2j0dA-5t13A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgy PS1

(Escherichia
coli) 		no annotation 5 ILE A  43
ILE A  39
PHE A  17
ALA A  16
ARG A   7
 None
 1.08A 2j0dA-5tgyA:
undetectable		 2j0dA-5tgyA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 5 ARG A 371
ILE A 428
ILE A 345
PHE A 346
ALA A 272
 None
None
None
None
9CR  A 503 (-3.5A)
 1.17A 2j0dA-5uanA:
undetectable		 2j0dA-5uanA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vai UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF00002
(7tm_2)
PF02793
(HRM) 		5 PHE R 184
ILE R 317
ILE R 313
ALA R 238
GLU R 247
 None
 1.12A 2j0dA-5vaiR:
undetectable		 2j0dA-5vaiR:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 5 ARG A 106
ALA A 305
ALA A 370
ARG A 372
GLU A 374
 RIT  A 602 ( 4.0A)
HEM  A 601 (-3.4A)
RIT  A 602 (-3.3A)
None
RIT  A 602 ( 4.8A)
 1.00A 2j0dA-5veuA:
50.1		 2j0dA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 5 ARG A 106
ALA A 305
THR A 309
ALA A 370
GLU A 374
 RIT  A 602 ( 4.0A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
RIT  A 602 ( 4.8A)
 0.92A 2j0dA-5veuA:
50.1		 2j0dA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 5 ILE A 301
ALA A 305
ALA A 370
ARG A 372
GLU A 374
 RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
RIT  A 602 (-3.3A)
None
RIT  A 602 ( 4.8A)
 1.11A 2j0dA-5veuA:
50.1		 2j0dA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 5 ILE A 301
ALA A 305
THR A 309
ALA A 370
GLU A 374
 RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
RIT  A 602 ( 4.8A)
 1.04A 2j0dA-5veuA:
50.1		 2j0dA-5veuA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 5 ILE A 185
PHE A 202
ALA A 181
THR A 179
ALA A 195
 None
 1.06A 2j0dA-5wt4A:
undetectable		 2j0dA-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN

(Streptomyces
fradiae) 		PF00440
(TetR_N) 		5 PHE A 201
ILE A  82
ILE A  81
ALA A 162
ARG A 178
 None
 1.04A 2j0dA-5xazA:
undetectable		 2j0dA-5xazA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		5 ARG A1780
ILE A1771
ILE A1755
ALA A1792
GLU A1788
 None
 1.17A 2j0dA-5xbfA:
undetectable		 2j0dA-5xbfA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 ILE A 168
ILE A 162
ALA A 175
ARG A 202
GLU A 210
 None
 1.12A 2j0dA-5y86A:
undetectable		 2j0dA-5y86A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A1348
ARG A 849
SER A 781
ILE A 782
ALA A 839
 None
 1.17A 2j0dA-6eojA:
undetectable		 2j0dA-6eojA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 5 ARG J  79
ILE J  61
ILE J 156
ARG J  48
GLU J  75
 None
 1.14A 2j0dA-6fhsJ:
undetectable		 2j0dA-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 5 ILE J  61
ILE J 156
ALA J  49
ARG J  48
GLU J  75
 None
 1.13A 2j0dA-6fhsJ:
undetectable		 2j0dA-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 5 ILE A  45
PHE A 455
ALA A 456
ALA A 461
ARG A 465
 None
 0.99A 2j0dA-6fhvA:
undetectable		 2j0dA-6fhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 5 ILE A 248
ILE A 192
PHE A 195
ALA A 196
GLU A 448
 None
 0.92A 2j0dA-6fsaA:
undetectable		 2j0dA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 5 SER A 424
ILE A 442
PHE A 393
ALA A 390
ALA A 142
 None
None
None
GLN  A 601 ( 4.1A)
None
 1.15A 2j0dA-6gctA:
undetectable		 2j0dA-6gctA:
undetectable