SIMILAR PATTERNS OF AMINO ACIDS FOR 2IZQ_D_DVAD6_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqy | PLASMINOGENACTIVATOR (Trimeresurusstejnegeri) |
PF00089(Trypsin) | 3 | TRP A 215ALA A 55VAL A 99 | NoneNone0GJ A 1 ( 4.2A) | 0.87A | 2izqC-1bqyA:undetectable2izqD-1bqyA:undetectable | 2izqC-1bqyA:7.012izqD-1bqyA:7.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ee6 | PECTATE LYASE (Bacillus sp.KSM-P15) |
PF03211(Pectate_lyase) | 3 | TRP A 78ALA A 59VAL A 81 | NoneNone CA A 300 (-4.9A) | 0.98A | 2izqC-1ee6A:undetectable2izqD-1ee6A:undetectable | 2izqC-1ee6A:7.752izqD-1ee6A:7.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezw | COENZYMEF420-DEPENDENTN5,N10-METHYLENETETRAHYDROMETHANOPTERINREDUCTASE (Methanopyruskandleri) |
PF00296(Bac_luciferase) | 3 | TRP A 117ALA A 130VAL A 154 | None | 0.87A | 2izqC-1ezwA:undetectable2izqD-1ezwA:undetectable | 2izqC-1ezwA:4.632izqD-1ezwA:4.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f2j | FRUCTOSE-BISPHOSPHATE ALDOLASE,GLYCOSOMAL (Trypanosomabrucei) |
PF00274(Glycolytic) | 3 | TRP A 323ALA A 332VAL A 330 | None | 0.98A | 2izqC-1f2jA:undetectable2izqD-1f2jA:undetectable | 2izqC-1f2jA:3.962izqD-1f2jA:3.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfw | CHITINASE B (Arthrobactersp. TAD20) |
PF00704(Glyco_hydro_18) | 3 | TRP A 378ALA A 335VAL A 338 | None | 0.83A | 2izqC-1kfwA:undetectable2izqD-1kfwA:undetectable | 2izqC-1kfwA:3.192izqD-1kfwA:3.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1l | RIBONUCLEOSIDETRIPHOSPHATEREDUCTASE (Lactobacillusleichmannii) |
PF02867(Ribonuc_red_lgC) | 3 | TRP A 120ALA A 321VAL A 163 | None | 0.98A | 2izqC-1l1lA:undetectable2izqD-1l1lA:undetectable | 2izqC-1l1lA:2.702izqD-1l1lA:2.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1l | RIBONUCLEOSIDETRIPHOSPHATEREDUCTASE (Lactobacillusleichmannii) |
PF02867(Ribonuc_red_lgC) | 3 | TRP A 642ALA A 646VAL A 547 | None | 0.93A | 2izqC-1l1lA:undetectable2izqD-1l1lA:undetectable | 2izqC-1l1lA:2.702izqD-1l1lA:2.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ma1 | SUPEROXIDE DISMUTASE (Methanothermobacterthermautotrophicus) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 3 | TRP A 131ALA A 126VAL A 148 | None | 0.97A | 2izqC-1ma1A:undetectable2izqD-1ma1A:undetectable | 2izqC-1ma1A:10.422izqD-1ma1A:10.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odo | PUTATIVE CYTOCHROMEP450 154A1 (Streptomycescoelicolor) |
PF00067(p450) | 3 | TRP A 81ALA A 184VAL A 174 | PIM A1408 (-4.6A)NoneNone | 0.83A | 2izqC-1odoA:undetectable2izqD-1odoA:undetectable | 2izqC-1odoA:14.862izqD-1odoA:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qfc | PROTEIN (PURPLE ACIDPHOSPHATASE) (Rattusnorvegicus) |
PF00149(Metallophos) | 3 | TRP A 15ALA A 241VAL A 12 | None | 0.87A | 2izqC-1qfcA:undetectable2izqD-1qfcA:undetectable | 2izqC-1qfcA:5.002izqD-1qfcA:5.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhq | PROTEIN (AURACYANIN) (Chloroflexusaurantiacus) |
PF00127(Copper-bind) | 3 | TRP A 59ALA A 23VAL A 21 | None | 0.98A | 2izqC-1qhqA:undetectable2izqD-1qhqA:undetectable | 2izqC-1qhqA:6.432izqD-1qhqA:6.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rbl | RIBULOSE 1,5BISPHOSPHATECARBOXYLASE/OXYGENASE (LARGE CHAIN) (Synechococcuselongatus) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 3 | TRP A 70ALA A 15VAL A 69 | None | 0.69A | 2izqC-1rblA:undetectable2izqD-1rblA:undetectable | 2izqC-1rblA:4.082izqD-1rblA:4.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5w | HYPOTHETICAL UPF0244PROTEIN YJJX (Escherichiacoli) |
PF01931(NTPase_I-T) | 3 | TRP A 75ALA A 77VAL A 8 | None | 0.81A | 2izqC-1u5wA:undetectable2izqD-1u5wA:undetectable | 2izqC-1u5wA:6.182izqD-1u5wA:6.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7g | PROBABLE AMMONIUMTRANSPORTER (Escherichiacoli) |
PF00909(Ammonium_transp) | 3 | TRP A 365ALA A 174VAL A 369 | None | 0.91A | 2izqC-1u7gA:undetectable2izqD-1u7gA:undetectable | 2izqC-1u7gA:5.192izqD-1u7gA:5.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1up2 | CELA1 PROTEIN (Mycobacteriumtuberculosis) |
PF01341(Glyco_hydro_6) | 3 | TRP A 186ALA A 137VAL A 139 | None | 0.97A | 2izqC-1up2A:undetectable2izqD-1up2A:undetectable | 2izqC-1up2A:6.252izqD-1up2A:6.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcg | THIOGLUCOSIDASE (Brevicorynebrassicae) |
PF00232(Glyco_hydro_1) | 3 | TRP A 135ALA A 181VAL A 171 | None | 0.97A | 2izqC-1wcgA:undetectable2izqD-1wcgA:undetectable | 2izqC-1wcgA:3.352izqD-1wcgA:3.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y43 | ASPERGILLOPEPSIN IIHEAVY CHAIN (Aspergillusniger) |
PF01828(Peptidase_A4) | 3 | TRP B 107ALA B 9VAL B 11 | None | 0.59A | 2izqC-1y43B:undetectable2izqD-1y43B:undetectable | 2izqC-1y43B:6.132izqD-1y43B:6.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a7w | PHOSPHORIBOSYL-ATPPYROPHOSPHATASE (Chromobacteriumviolaceum) |
PF01503(PRA-PH) | 3 | TRP A 68ALA A 45VAL A 64 | None | 0.87A | 2izqC-2a7wA:undetectable2izqD-2a7wA:undetectable | 2izqC-2a7wA:8.042izqD-2a7wA:8.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2btd | PTS-DEPENDENTDIHYDROXYACETONEKINASE (Escherichiacoli) |
PF02734(Dak2) | 3 | TRP A 134ALA A 123VAL A 117 | NoneADP A1211 ( 4.4A)None | 0.96A | 2izqC-2btdA:undetectable2izqD-2btdA:undetectable | 2izqC-2btdA:7.522izqD-2btdA:7.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2co6 | PUTATIVE FIMBRIAEASSEMBLY CHAPERONE (Salmonellaenterica) |
PF00345(PapD_N)PF02753(PapD_C) | 3 | TRP B 203ALA B 168VAL B 170 | None | 0.83A | 2izqC-2co6B:undetectable2izqD-2co6B:undetectable | 2izqC-2co6B:8.052izqD-2co6B:8.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cwf | DELTA1-PIPERIDEINE-2-CARBOXYLATEREDUCTASE (Pseudomonassyringae groupgenomosp. 3) |
PF02615(Ldh_2) | 3 | TRP A 70ALA A 67VAL A 71 | None | 0.88A | 2izqC-2cwfA:undetectable2izqD-2cwfA:undetectable | 2izqC-2cwfA:6.222izqD-2cwfA:6.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3y | URACIL-DNAGLYCOSYLASE (Thermusthermophilus) |
PF03167(UDG) | 3 | TRP A 39ALA A 116VAL A 43 | None | 0.91A | 2izqC-2d3yA:undetectable2izqD-2d3yA:undetectable | 2izqC-2d3yA:8.732izqD-2d3yA:8.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4w | GLYCEROL KINASE (Cellulomonassp.) |
PF00370(FGGY_N)PF02782(FGGY_C) | 3 | TRP A 102ALA A 85VAL A 101 | MPD A 1 ( 3.9A)NoneNone | 0.96A | 2izqC-2d4wA:undetectable2izqD-2d4wA:undetectable | 2izqC-2d4wA:4.982izqD-2d4wA:4.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ffi | 2-PYRONE-4,6-DICARBOXYLIC ACIDHYDROLASE, PUTATIVE (Pseudomonasputida) |
PF04909(Amidohydro_2) | 3 | TRP A 233ALA A 215VAL A 198 | None | 0.94A | 2izqC-2ffiA:undetectable2izqD-2ffiA:undetectable | 2izqC-2ffiA:5.682izqD-2ffiA:5.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vob | TRYPANOTHIONESYNTHETASE (Leishmaniamajor) |
PF03738(GSP_synth)PF05257(CHAP) | 3 | TRP A 66ALA A 32VAL A 30 | None | 0.94A | 2izqC-2vobA:undetectable2izqD-2vobA:undetectable | 2izqC-2vobA:3.502izqD-2vobA:3.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vtc | CEL61B (Trichodermareesei) |
PF03443(Glyco_hydro_61) | 3 | TRP A 228ALA A 226VAL A 116 | None | 0.91A | 2izqC-2vtcA:undetectable2izqD-2vtcA:undetectable | 2izqC-2vtcA:4.842izqD-2vtcA:4.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wk8 | CAI-1 AUTOINDUCERSYNTHASE (Vibrio cholerae) |
PF00155(Aminotran_1_2) | 3 | TRP A 109ALA A 111VAL A 113 | None | 0.95A | 2izqC-2wk8A:undetectable2izqD-2wk8A:undetectable | 2izqC-2wk8A:5.562izqD-2wk8A:5.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axx | 458AA LONGHYPOTHETICALENDO-1,4-BETA-GLUCANASE (Pyrococcushorikoshii) |
PF00150(Cellulase) | 3 | TRP A 323ALA A 271VAL A 298 | None | 0.80A | 2izqC-3axxA:undetectable2izqD-3axxA:undetectable | 2izqC-3axxA:3.232izqD-3axxA:3.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c8t | FUMARATE LYASE (Chelativoranssp. BNC1) |
PF00206(Lyase_1)PF10397(ADSL_C) | 3 | TRP A 180ALA A 183VAL A 179 | None | 0.82A | 2izqC-3c8tA:undetectable2izqD-3c8tA:undetectable | 2izqC-3c8tA:5.332izqD-3c8tA:5.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e2s | PROLINEDEHYDROGENASE (Escherichiacoli) |
PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 3 | TRP A 438ALA A 405VAL A 455 | FAD A2001 (-3.6A)NoneNone | 0.85A | 2izqC-3e2sA:undetectable2izqD-3e2sA:undetectable | 2izqC-3e2sA:1.862izqD-3e2sA:1.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsc | QDTC (Thermoanaerobacteriumthermosaccharolyticum) |
PF00132(Hexapep) | 3 | TRP A 239ALA A 195VAL A 178 | None | 0.98A | 2izqC-3fscA:undetectable2izqD-3fscA:undetectable | 2izqC-3fscA:13.892izqD-3fscA:13.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i2t | EPIDERMAL GROWTHFACTOR RECEPTOR,ISOFORM A (Drosophilamelanogaster) |
PF00757(Furin-like)PF01030(Recep_L_domain)PF14843(GF_recep_IV) | 3 | TRP A 457ALA A 405VAL A 430 | None | 0.89A | 2izqC-3i2tA:undetectable2izqD-3i2tA:undetectable | 2izqC-3i2tA:3.282izqD-3i2tA:3.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ian | CHITINASE (Lactococcuslactis) |
PF00704(Glyco_hydro_18) | 3 | TRP A 49ALA A 327VAL A 323 | NoneEDO A 364 ( 4.2A)None | 0.95A | 2izqC-3ianA:undetectable2izqD-3ianA:undetectable | 2izqC-3ianA:3.252izqD-3ianA:3.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibh | SACCHAROMYCESCEREVISIAE GTT2 (Saccharomycescerevisiae) |
PF00043(GST_C)PF13417(GST_N_3) | 3 | TRP A 151ALA A 135VAL A 130 | None | 0.96A | 2izqC-3ibhA:undetectable2izqD-3ibhA:undetectable | 2izqC-3ibhA:6.582izqD-3ibhA:6.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ieg | DNAJ HOMOLOGSUBFAMILY C MEMBER 3 (Mus musculus) |
PF09976(TPR_21)PF13181(TPR_8) | 3 | TRP A 186ALA A 188VAL A 185 | None | 0.98A | 2izqC-3iegA:undetectable2izqD-3iegA:undetectable | 2izqC-3iegA:4.812izqD-3iegA:4.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ix7 | UNCHARACTERIZEDPROTEIN TTHA0540 (Thermusthermophilus) |
no annotation | 3 | TRP A 169ALA A 235VAL A 144 | None | 0.97A | 2izqC-3ix7A:undetectable2izqD-3ix7A:undetectable | 2izqC-3ix7A:20.002izqD-3ix7A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8h | PUTATIVE HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bordetellabronchiseptica) |
PF13242(Hydrolase_like) | 3 | TRP A 142ALA A 134VAL A 124 | None | 0.90A | 2izqC-3l8hA:undetectable2izqD-3l8hA:undetectable | 2izqC-3l8hA:9.682izqD-3l8hA:9.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3njb | ENOYL-COA HYDRATASE (Mycolicibacteriumsmegmatis) |
PF00378(ECH_1) | 3 | TRP A 177ALA A 281VAL A 283 | None | 0.96A | 2izqC-3njbA:undetectable2izqD-3njbA:undetectable | 2izqC-3njbA:6.802izqD-3njbA:6.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oft | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 3 | TRP A 61ALA A 342VAL A 340 | HEM A 417 (-4.1A)NoneNone | 0.61A | 2izqC-3oftA:undetectable2izqD-3oftA:undetectable | 2izqC-3oftA:19.642izqD-3oftA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oq3 | INTERFERON ALPHA-5 (Mus musculus) |
PF00143(Interferon) | 3 | TRP A 149ALA A 14VAL A 19 | None | 0.89A | 2izqC-3oq3A:undetectable2izqD-3oq3A:undetectable | 2izqC-3oq3A:9.022izqD-3oq3A:9.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6f | HYPOTHETICALACETYLTRANSFERASE (Deinococcusradiodurans) |
PF13673(Acetyltransf_10) | 3 | TRP A 40ALA A 21VAL A 18 | TRP A 40 ( 0.5A)ALA A 21 ( 0.0A)VAL A 18 ( 0.5A) | 0.94A | 2izqC-3s6fA:undetectable2izqD-3s6fA:undetectable | 2izqC-3s6fA:7.872izqD-3s6fA:7.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6s | CERJ (Streptomycestendae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 3 | TRP A 3ALA A 251VAL A 182 | None | 0.92A | 2izqC-3t6sA:undetectable2izqD-3t6sA:undetectable | 2izqC-3t6sA:14.462izqD-3t6sA:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3unv | ADMH (Pantoeaagglomerans) |
PF00221(Lyase_aromatic) | 3 | TRP A 185ALA A 178VAL A 180 | None | 0.93A | 2izqC-3unvA:undetectable2izqD-3unvA:undetectable | 2izqC-3unvA:6.472izqD-3unvA:6.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w36 | NAPH1 (Streptomycessp. CNQ525) |
no annotation | 3 | TRP A 146ALA A 186VAL A 98 | None | 0.90A | 2izqC-3w36A:undetectable2izqD-3w36A:undetectable | 2izqC-3w36A:4.622izqD-3w36A:4.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w6m | 458AA LONGHYPOTHETICALENDO-1,4-BETA-GLUCANASE (Pyrococcushorikoshii) |
PF00150(Cellulase) | 3 | TRP A 323ALA A 271VAL A 298 | None | 0.78A | 2izqC-3w6mA:undetectable2izqD-3w6mA:undetectable | 2izqC-3w6mA:3.532izqD-3w6mA:3.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4abn | TETRATRICOPEPTIDEREPEAT PROTEIN 5 (Mus musculus) |
PF16669(TTC5_OB) | 3 | TRP A 182ALA A 220VAL A 216 | None | 0.97A | 2izqC-4abnA:undetectable2izqD-4abnA:undetectable | 2izqC-4abnA:2.392izqD-4abnA:2.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4akk | NITRATE REGULATORYPROTEIN (Klebsiellaoxytoca) |
PF03861(ANTAR)PF08376(NIT) | 3 | TRP A 56ALA A 124VAL A 118 | None | 0.97A | 2izqC-4akkA:undetectable2izqD-4akkA:undetectable | 2izqC-4akkA:3.242izqD-4akkA:3.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4akk | NITRATE REGULATORYPROTEIN (Klebsiellaoxytoca) |
PF03861(ANTAR)PF08376(NIT) | 3 | TRP A 56ALA A 125VAL A 118 | None | 0.79A | 2izqC-4akkA:undetectable2izqD-4akkA:undetectable | 2izqC-4akkA:3.242izqD-4akkA:3.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cf3 | L-HALOACIDDEHALOGENASE (Rhodobacteraceae) |
PF00702(Hydrolase) | 3 | TRP A 46ALA A 78VAL A 73 | None | 0.97A | 2izqC-4cf3A:undetectable2izqD-4cf3A:undetectable | 2izqC-4cf3A:3.622izqD-4cf3A:3.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4di1 | ENOYL-COA HYDRATASEECHA17 (Mycobacteriummarinum) |
PF00378(ECH_1) | 3 | TRP A 192ALA A 49VAL A 98 | None | 0.93A | 2izqC-4di1A:undetectable2izqD-4di1A:undetectable | 2izqC-4di1A:17.392izqD-4di1A:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eb0 | LCC (unculturedbacterium) |
PF12695(Abhydrolase_5) | 3 | TRP A 259ALA A 160VAL A 185 | None | 0.85A | 2izqC-4eb0A:undetectable2izqD-4eb0A:undetectable | 2izqC-4eb0A:16.672izqD-4eb0A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4el8 | GLYCOSIDE HYDROLASEFAMILY 48 (Caldicellulosiruptorbescii) |
PF02011(Glyco_hydro_48) | 3 | TRP A 62ALA A 238VAL A 66 | None | 0.93A | 2izqC-4el8A:undetectable2izqD-4el8A:undetectable | 2izqC-4el8A:2.452izqD-4el8A:2.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4epa | PESTICIN RECEPTOR (Yersinia pestis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | TRP A 513ALA A 468VAL A 470 | None | 0.79A | 2izqC-4epaA:undetectable2izqD-4epaA:undetectable | 2izqC-4epaA:2.152izqD-4epaA:2.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcs | VERSATILE PEROXIDASEVPL2 (Pleurotuseryngii) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 3 | TRP A 164ALA A 167VAL A 163 | None | 0.71A | 2izqC-4fcsA:undetectable2izqD-4fcsA:undetectable | 2izqC-4fcsA:6.252izqD-4fcsA:6.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fom | POLIOVIRUSRECEPTOR-RELATEDPROTEIN 3 (Homo sapiens) |
PF07686(V-set)PF08205(C2-set_2) | 3 | TRP A 70ALA A 68VAL A 168 | NAG A 415 ( 4.1A)NoneNAG A 415 ( 4.6A) | 0.83A | 2izqC-4fomA:undetectable2izqD-4fomA:undetectable | 2izqC-4fomA:4.862izqD-4fomA:4.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ftd | UNCHARACTERIZEDPROTEIN (Bacteroideseggerthii) |
PF15416(DUF4623) | 3 | TRP A 334ALA A 362VAL A 323 | None | 0.83A | 2izqC-4ftdA:undetectable2izqD-4ftdA:undetectable | 2izqC-4ftdA:2.432izqD-4ftdA:2.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hi4 | AEROTAXIS TRANSDUCERAER2 (Pseudomonasaeruginosa) |
PF13188(PAS_8) | 3 | TRP A 283ALA A 184VAL A 202 | None | 0.60A | 2izqC-4hi4A:undetectable2izqD-4hi4A:undetectable | 2izqC-4hi4A:8.742izqD-4hi4A:8.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6k | AMIDOHYDROLASEFAMILY PROTEIN (Acinetobacterbaumannii) |
PF04909(Amidohydro_2) | 3 | TRP A 223ALA A 205VAL A 189 | None | 0.93A | 2izqC-4i6kA:undetectable2izqD-4i6kA:undetectable | 2izqC-4i6kA:6.032izqD-4i6kA:6.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i9r | CELLULAR RETINOICACID-BINDING PROTEIN2 (Homo sapiens) |
PF00061(Lipocalin) | 3 | TRP A 32ALA A 35VAL A 33 | RET A 201 (-4.5A)NoneNone | 0.76A | 2izqC-4i9rA:undetectable2izqD-4i9rA:undetectable | 2izqC-4i9rA:10.482izqD-4i9rA:10.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j4j | DNA DC->DU-EDITINGENZYME APOBEC-3F (Homo sapiens) |
PF08210(APOBEC_N) | 3 | TRP A 277ALA A 250VAL A 242 | None | 0.81A | 2izqC-4j4jA:undetectable2izqD-4j4jA:undetectable | 2izqC-4j4jA:5.672izqD-4j4jA:5.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kna | N-SUCCINYLGLUTAMATE5-SEMIALDEHYDEDEHYDROGENASE (Burkholderiathailandensis) |
PF00171(Aldedh) | 3 | TRP A 185ALA A 180VAL A 182 | None | 0.93A | 2izqC-4knaA:undetectable2izqD-4knaA:undetectable | 2izqC-4knaA:2.722izqD-4knaA:2.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m2j | AMINOTRANSFERASE (Streptomyceslavendulae) |
PF00155(Aminotran_1_2) | 3 | TRP A 236ALA A 239VAL A 85 | None | 0.89A | 2izqC-4m2jA:undetectable2izqD-4m2jA:undetectable | 2izqC-4m2jA:3.692izqD-4m2jA:3.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mbg | CAAXFARNESYLTRANSFERASEALPHA SUBUNIT RAM2 (Aspergillusfumigatus) |
PF01239(PPTA) | 3 | TRP A 295ALA A 297VAL A 299 | None | 0.96A | 2izqC-4mbgA:undetectable2izqD-4mbgA:undetectable | 2izqC-4mbgA:4.032izqD-4mbgA:4.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mkv | RIBULOSEBISPHOSPHATECARBOXYLASE LARGECHAIN (Pisum sativum) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 3 | TRP A 70ALA A 15VAL A 69 | None | 0.65A | 2izqC-4mkvA:undetectable2izqD-4mkvA:undetectable | 2izqC-4mkvA:3.792izqD-4mkvA:3.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nme | PROLINEDEHYDROGENASE ANDDELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE (Geobactersulfurreducens) |
PF00171(Aldedh)PF01619(Pro_dh) | 3 | TRP A 310ALA A 277VAL A 326 | P5F A1101 (-3.6A)NoneNone | 0.87A | 2izqC-4nmeA:undetectable2izqD-4nmeA:undetectable | 2izqC-4nmeA:2.232izqD-4nmeA:2.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o8a | BIFUNCTIONAL PROTEINPUTA (Escherichiacoli) |
PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 3 | TRP A 438ALA A 405VAL A 455 | FAD A2001 (-3.5A)NoneNone | 0.85A | 2izqC-4o8aA:undetectable2izqD-4o8aA:undetectable | 2izqC-4o8aA:3.022izqD-4o8aA:3.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4og1 | ENOYL-COAHYDRATASE/ISOMERASE (Novosphingobiumaromaticivorans) |
PF00378(ECH_1) | 3 | TRP A 103ALA A 154VAL A 125 | None | 0.86A | 2izqC-4og1A:undetectable2izqD-4og1A:undetectable | 2izqC-4og1A:7.562izqD-4og1A:7.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqr | CYP105AS1 (Amycolatopsisorientalis) |
PF00067(p450) | 3 | TRP A 48ALA A 290VAL A 308 | None | 0.98A | 2izqC-4oqrA:undetectable2izqD-4oqrA:undetectable | 2izqC-4oqrA:3.202izqD-4oqrA:3.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pvi | GH62 HYDROLASE (Mycothermusthermophilus) |
PF03664(Glyco_hydro_62) | 3 | TRP A 34ALA A 288VAL A 290 | None | 0.72A | 2izqC-4pviA:undetectable2izqD-4pviA:undetectable | 2izqC-4pviA:3.272izqD-4pviA:3.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q73 | PROLINEDEHYDROGENASE (Bradyrhizobiumdiazoefficiens) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 3 | TRP A 346ALA A 313VAL A 363 | FAD A2001 (-3.6A)NoneNone | 0.88A | 2izqC-4q73A:undetectable2izqD-4q73A:undetectable | 2izqC-4q73A:2.582izqD-4q73A:2.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a42 | UNCHARACTERIZEDLIPOPROTEIN YFHM (Escherichiacoli) |
PF00207(A2M)PF01835(A2M_N)PF07703(A2M_N_2)PF11974(MG1) | 3 | TRP A1252ALA A1303VAL A1308 | None | 0.95A | 2izqC-5a42A:undetectable2izqD-5a42A:undetectable | 2izqC-5a42A:1.052izqD-5a42A:1.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7m | BETA-XYLOSIDASE (Trichodermareesei) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 3 | TRP A 501ALA A 578VAL A 529 | None | 0.80A | 2izqC-5a7mA:undetectable2izqD-5a7mA:undetectable | 2izqC-5a7mA:1.952izqD-5a7mA:1.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITALPHA (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 3 | TRP A 229ALA A 166VAL A 213 | None | 0.87A | 2izqC-5a8rA:undetectable2izqD-5a8rA:undetectable | 2izqC-5a8rA:4.082izqD-5a8rA:4.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aca | VP1 (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | TRP 1 89ALA 1 50VAL 1 173 | None | 0.82A | 2izqC-5aca1:undetectable2izqD-5aca1:undetectable | 2izqC-5aca1:10.612izqD-5aca1:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b22 | NECTIN-3 (Mus musculus) |
PF07686(V-set)PF08205(C2-set_2) | 3 | TRP A 12ALA A 10VAL A 110 | NAG A 301 (-3.4A)NoneNone | 0.96A | 2izqC-5b22A:undetectable2izqD-5b22A:undetectable | 2izqC-5b22A:5.502izqD-5b22A:5.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cju | ISOBUTYRYL-COAMUTASE FUSED (Cupriavidusmetallidurans) |
PF01642(MM_CoA_mutase)PF02310(B12-binding)PF03308(ArgK) | 3 | TRP A 368ALA A 355VAL A 391 | None | 0.98A | 2izqC-5cjuA:undetectable2izqD-5cjuA:undetectable | 2izqC-5cjuA:2.132izqD-5cjuA:2.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5clw | 1,4-ALPHA-GLUCAN-BRANCHING ENZYME (Homo sapiens) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 3 | TRP A 548ALA A 483VAL A 485 | None | 0.89A | 2izqC-5clwA:undetectable2izqD-5clwA:undetectable | 2izqC-5clwA:2.522izqD-5clwA:2.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7l | CONTACTIN-2 (Mus musculus) |
PF00041(fn3) | 3 | TRP A 835ALA A 819VAL A 821 | None | 0.98A | 2izqC-5e7lA:undetectable2izqD-5e7lA:undetectable | 2izqC-5e7lA:10.672izqD-5e7lA:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ebb | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3A (Homo sapiens) |
PF00149(Metallophos) | 3 | TRP A 107ALA A 318VAL A 43 | None | 0.89A | 2izqC-5ebbA:undetectable2izqD-5ebbA:undetectable | 2izqC-5ebbA:3.982izqD-5ebbA:3.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewn | STRUCTURAL PROTEIN (Mamastrovirus 1) |
PF03115(Astro_capsid_N) | 3 | TRP A 351ALA A 376VAL A 369 | None | 0.87A | 2izqC-5ewnA:undetectable2izqD-5ewnA:undetectable | 2izqC-5ewnA:6.372izqD-5ewnA:6.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fca | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3A (Mus musculus) |
PF00149(Metallophos) | 3 | TRP A 104ALA A 315VAL A 40 | None | 0.87A | 2izqC-5fcaA:undetectable2izqD-5fcaA:undetectable | 2izqC-5fcaA:5.502izqD-5fcaA:5.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g06 | EXOSOME COMPLEXCOMPONENT RRP4 (Saccharomycescerevisiae) |
PF14382(ECR1_N)PF15985(KH_6) | 3 | TRP H 124ALA H 117VAL H 119 | None | 0.69A | 2izqC-5g06H:undetectable2izqD-5g06H:undetectable | 2izqC-5g06H:4.712izqD-5g06H:4.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k0t | METHIONINE--TRNALIGASE (Brucella suis) |
PF08264(Anticodon_1)PF09334(tRNA-synt_1g) | 3 | TRP A 109ALA A 111VAL A 113 | None | 0.94A | 2izqC-5k0tA:undetectable2izqD-5k0tA:undetectable | 2izqC-5k0tA:5.422izqD-5k0tA:5.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kf7 | BIFUNCTIONAL PROTEINPUTA (Sinorhizobiummeliloti) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 3 | TRP A 374ALA A 341VAL A 391 | FAD A2001 (-3.6A)NoneNone | 0.87A | 2izqC-5kf7A:undetectable2izqD-5kf7A:undetectable | 2izqC-5kf7A:1.642izqD-5kf7A:1.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5koh | NITROGENASE FEMOBETA SUBUNIT PROTEINNIFK (Gluconacetobacterdiazotrophicus) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 3 | TRP B 473ALA B 478VAL B 472 | None | 0.59A | 2izqC-5kohB:undetectable2izqD-5kohB:undetectable | 2izqC-5kohB:3.102izqD-5kohB:3.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lpe | KALLIKREIN-10 (Homo sapiens) |
PF00089(Trypsin) | 3 | TRP A 29ALA A 43VAL A 45 | None | 0.84A | 2izqC-5lpeA:undetectable2izqD-5lpeA:undetectable | 2izqC-5lpeA:11.252izqD-5lpeA:11.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n28 | METHYL-COENZYME MREDUCTASE SUBUNITALPHA (Methanotorrisformicicus) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 3 | TRP A 229ALA A 166VAL A 213 | None | 0.88A | 2izqC-5n28A:undetectable2izqD-5n28A:undetectable | 2izqC-5n28A:2.322izqD-5n28A:2.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nbi | DESIGN OF ANTIBODIES (Escherichiacoli) |
PF07654(C1-set)PF07686(V-set) | 3 | TRP L 39ALA L 54VAL L 52 | None | 0.97A | 2izqC-5nbiL:undetectable2izqD-5nbiL:undetectable | 2izqC-5nbiL:13.512izqD-5nbiL:13.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nv3 | RIBULOSEBISPHOSPHATECARBOXYLASE LARGECHAIN (Rhodobactersphaeroides) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 3 | TRP A 72ALA A 16VAL A 71 | None | 0.64A | 2izqC-5nv3A:undetectable2izqD-5nv3A:undetectable | 2izqC-5nv3A:3.902izqD-5nv3A:3.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o7g | ALPHA/BETA HYDROLASEFAMILY PROTEIN (Bacilluscoagulans) |
no annotation | 3 | TRP A 80ALA A 71VAL A 65 | None | 0.82A | 2izqC-5o7gA:undetectable2izqD-5o7gA:undetectable | 2izqC-5o7gA:undetectable2izqD-5o7gA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o82 | INTRACELLULAREXO-ALPHA-(1->5)-L-ARABINOFURANOSIDASE (Chaetomiumthermophilum) |
no annotation | 3 | TRP A 224ALA A 226VAL A 228 | None | 0.98A | 2izqC-5o82A:undetectable2izqD-5o82A:undetectable | 2izqC-5o82A:undetectable2izqD-5o82A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5okz | EXOSOME COMPLEXCOMPONENT RRP4 (Saccharomycescerevisiae) |
PF14382(ECR1_N)PF15985(KH_6) | 3 | TRP H 124ALA H 117VAL H 119 | None | 0.77A | 2izqC-5okzH:undetectable2izqD-5okzH:undetectable | 2izqC-5okzH:5.082izqD-5okzH:5.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tkm | DNA DC->DU-EDITINGENZYME APOBEC-3B (Homo sapiens) |
PF08210(APOBEC_N) | 3 | TRP A 94ALA A 67VAL A 59 | None | 0.88A | 2izqC-5tkmA:undetectable2izqD-5tkmA:undetectable | 2izqC-5tkmA:6.542izqD-5tkmA:6.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u0s | MEDIATOR COMPLEXSUBUNIT 8MEDIATOR COMPLEXSUBUNIT 18 (Schizosaccharomycespombe;Schizosaccharomycespombe) |
PF10232(Med8)PF09637(Med18) | 3 | TRP R 165ALA H 184VAL R 10 | None | 0.93A | 2izqC-5u0sR:undetectable2izqD-5u0sR:undetectable | 2izqC-5u0sR:12.332izqD-5u0sR:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uld | TRANSPORTER, NADCFAMILY (Vibrio cholerae) |
PF00939(Na_sulph_symp) | 3 | TRP A 59ALA A 63VAL A 66 | None | 0.71A | 2izqC-5uldA:undetectable2izqD-5uldA:undetectable | 2izqC-5uldA:2.972izqD-5uldA:2.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ur2 | BIFUNCTIONAL PROTEINPUTA (Bdellovibriobacteriovorus) |
PF00171(Aldedh)PF01619(Pro_dh) | 3 | TRP A 305ALA A 272VAL A 321 | P5F A1001 (-3.7A)NoneNone | 0.94A | 2izqC-5ur2A:undetectable2izqD-5ur2A:undetectable | 2izqC-5ur2A:2.822izqD-5ur2A:2.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf4 | UNCHARACTERIZEDPROTEIN (Thermusaquaticus) |
PF03781(FGE-sulfatase) | 3 | TRP A 201ALA A 90VAL A 373 | None | 0.83A | 2izqC-5vf4A:undetectable2izqD-5vf4A:undetectable | 2izqC-5vf4A:6.062izqD-5vf4A:6.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsx | CHITINASE (Thermococcuschitonophagus) |
no annotation | 3 | TRP A 682ALA A 646VAL A 680 | None | 0.88A | 2izqC-5xsxA:undetectable2izqD-5xsxA:undetectable | 2izqC-5xsxA:undetectable2izqD-5xsxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yim | SDEA (Legionellapneumophila) |
no annotation | 3 | TRP A 394ALA A 399VAL A 401 | None | 0.72A | 2izqC-5yimA:undetectable2izqD-5yimA:undetectable | 2izqC-5yimA:undetectable2izqD-5yimA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 3 | TRP A 183ALA A 187VAL A 182 | None | 0.98A | 2izqC-6c66A:undetectable2izqD-6c66A:undetectable | 2izqC-6c66A:undetectable2izqD-6c66A:undetectable |